06th week of 2013 patent applcation highlights part 36 |
Patent application number | Title | Published |
20130035197 | PLANETARY GEAR TRAIN AND CORRESPONDING PRODUCTION METHOD - Described herein is a planetary gear train, comprising: a sun gear that can turn about an axis and comprises a plurality of first teeth; a fixed crown wheel comprising a plurality of second teeth; and two planetary gears, each comprising a plurality of third teeth, the planetary gears each meshing with the crown wheel and the sun gear and able to turn about second axes, which are in turn able to turn about the first axis; at least two third teeth simultaneously mesh with second teeth and further two third teeth simultaneously mesh with first teeth; the third teeth comprise a first a second side, which have, respectively, a first and a second pressure angle different from one another; and the number of the third teeth is different from the absolute value of the semidifference between the number of the first teeth and of the second teeth. | 2013-02-07 |
20130035198 | GEARBOX COMPRISING A STATIONARY GEAR COMPONENT FORMED ON THE BASIS OF VARIABLE FLANK PROFILES OF GEAR TEETH - In a gearbox, a stationary gear component such as a ring gear of a planetary gear comprises a tooth trace correction that varies along the tooth trace so as to provide for superior load distribution in the gearbox. In some illustrative embodiments, the gearbox is a component of a wind power plant wherein the circumferentially varying tooth trace correction of the stationary ring gear results in superior durability and performance. | 2013-02-07 |
20130035199 | Apparatus and method for transferring torque - A traction drive apparatus is provided for transferring torque from an input rotating shaft to an in-line, or co-axial, output rotating shaft. More specifically, the invention is a gearless, friction drive, in-line, rotating speed reducer or speed increaser for use in a wide variety of rotating equipment applications. The apparatus of the instant invention employs a retainer of a plurality of bearing means to transfer torque from an input shaft to an output shaft, wherein the retainer is either non-rotating or rotating. | 2013-02-07 |
20130035200 | TOROIDAL CONTINUOUSLY VARIABLE TRANSMISSION - The present invention achieves construction of a toroidal continuously variable transmission of which manufacture, management and assembly of parts can be performed easily, reduction of cost is easy and speed change operation is stabilized. This construction comprises support holes | 2013-02-07 |
20130035201 | Method and Device for Operating A Hybrid Vehicle - A method for operating a hybrid vehicle, having at least one first drive unit and one second drive unit, the second drive unit being started by at least one portion of the drive torque provided by the first drive unit in that the clutch situated between the first drive unit and the second drive unit is brought from a disengaged state into a slipping state. To improve the driving comfort of the hybrid vehicle during a start or a stop of the internal combustion engine, at least two clutches are shifted into the slipping state for starting the second drive unit. | 2013-02-07 |
20130035202 | POWER TRANSMISSION DEVICE - A power transmission device has a rigid body that includes a contact portion coming into contact with the first or second friction member and that moves the contact portion from a position of contact with the first or second friction member to a position of no contact with the first and second friction members, an elastic body that applies to the rigid body a force moving the contact portion to a position of contact with the first or second friction member, a first pushing mechanism that applies to the rigid body a pressure of liquid moving the contact portion to a position of contact with the first or second friction member, and a second pushing mechanism that applies to the rigid body a pressure of liquid moving the contact portion to a position of no contact with the first and second friction members. | 2013-02-07 |
20130035203 | CONTROL DEVICE FOR DRIVE MOTORS - A control system for driving motor configured to synchronize rotor phases of a plurality of driving motors of wheels using a single inverter. The control system comprises driving motor connected with a wheel to drive the wheel; a clutch interposed between the driving motor and the wheel; and a current control means connected with the driving motor to supply current thereto. A switching unit switches electrical connection in a manner to supply the current to both of the driving motors from one of the current control unit by interrupting the current supply from the other current control unit. The clutch interrupts torque transmission in case the switching mechanism switches the electrical connection in a manner to supply the current to both of the driving motors from one of the current control unit to drive the vehicle. | 2013-02-07 |
20130035204 | MOTOR-GENERATOR SYSTEM DRIVEN BY V-BELT - A motor-generator system for a vehicle, in which power transmission between a crankshaft of an engine and a motor-generator is performed by a V-belt wound around pulleys thereof, includes a speed controller controlling the rotational speed of the V-belt within a predetermined range and provided on a crankshaft pulley mounted on the crankshaft. The motor-generator system, among others, can maintain the power transmission force of the V-belt at a high level. | 2013-02-07 |
20130035205 | METHOD FOR OPERATING A VEHICLE DRIVE TRAIN HAVING A DRIVING MACHINE AND HAVING A TRANSMISSION APPARATUS HAVING A PLURALITY OF SHIFT ELEMENTS - A method of operating a vehicle drive train having a drive machine, a transmission apparatus having a plurality of shift elements and an output drive. The plurality of shift elements are engaged or disengaged in a power flow for achieving different transmission ratios within the transmission apparatus. The output drive is coupled to a transmission output shaft and the drive machine is coupled to a transmission input shaft of the transmission apparatus. Upon a request to interrupt power flow within the transmission apparatus, between the transmission input shaft and the transmission output shaft, a maximum number of shift elements are transferred to and/or held in an engaged operating state, and the remaining portion of the shift elements are transferred to and/or held in a disengaged operating state with the transmission output shaft being rotatable. | 2013-02-07 |
20130035206 | METHOD FOR OPERATING A VEHICLE DRIVE TRAIN HAVING AN INTERNAL COMBUSTION ENGINE - A method of operating a vehicle drive-train comprising an internal combustion engine and a transmission system functionally connected to the internal combustion engine. The transmission has an interlocking shifting element, one shifting element half of which is functionally connected to the transmission input shaft while the other shifting element half is functionally connected to a transmission output shaft. Upon receipt of a command to change the transmission from a neutral position, in which a force flow through the transmission is interrupted, to an operating condition, in which the force flow through the transmission is produced, the interlocking shifting element is changed to an engaged operating condition. A speed difference between the shifting element halves is brought by varying the speed of the internal combustion engine into a speed difference window within which the interlocking shifting element can be changed to its engaged operating condition. | 2013-02-07 |
20130035207 | ROUTINE-BASED MANAGEMENT OF EXERCISE EQUIPMENT ACCESS - A solution for managing access to exercise equipment in a fitness facility is provided. A planned exercise routine for a user, which includes data corresponding to a plurality of exercises desired to be performed by the user at the fitness facility is used for providing location information for presentation to the user. Each exercise can require use of an exercise apparatus. The exercise can be mapped to at least one exercise apparatus located at the fitness facility. A target exercise apparatus can be identified from the mapped exercise apparatus(es). Location information for one or more of the target exercise apparatuses can be provided for presentation to the user. | 2013-02-07 |
20130035208 | EXERCISE DEVICE WITH FAN CONTROLLABLE BY A PHYSIOLOGICAL CONDITION OF A USER - In general, exercise devices of the present invention include one or more fans that can increase the flow of air in particular direction. Exercise devices of the present invention also include a sensing mechanism that can sense a physiological condition of a user performing an exercise on the exercise device. The sensed physiological condition could be pulse, blood pressure, respiration, caloric expenditure, weight, perspiration, temperature, blood oxygen level, metabolic equivalent of task (MET), carbohydrates burned, cadence or another physiological condition. The speed of the air flow created by the fan can depend on the physiological condition sensed by the sensing mechanism. | 2013-02-07 |
20130035209 | DYNAMICALLY ADAPTIVE SCHEDULING SYSTEM - Methods and systems for providing a lifestyle companion system are provided. The lifestyle companion system can provide a platform to conduct a user interview. Based on the user interview responses, the system can suggest activities, references, and/or plug-in modules. During performance of activities, the system can provide audio and/or visual cues related to the activities and collect data indicative of the user's performance. Based on the collected data, the system can dynamically adapt the user's goals and/or activities the user is performing or will perform. In some embodiments of the present invention, the lifestyle companion system of the present invention can be applied to fitness, nutrition, and/or medical modules. The system also can be used to facilitate synchronous group activities. | 2013-02-07 |
20130035210 | Face Lift Exercise Device - A facial exercise device includes a handle, ring, tongue arm and flexible cheek arms. The device is inserted into a person's mouth and the person's cheeks are tightened against the resistance provided by the flexible cheek arms. An optional eyepiece includes connected flexible right and left eye portions and two or more protrusions extending outwardly. | 2013-02-07 |
20130035211 | Multi-Directional Adjustable Exercise Slide Board - An exercise apparatus providing a base having a top surface and a bottom surface, wherein the top surface is smooth and planar. The top surface includes a first plurality of apertures arranged in a circular pattern having a first diameter, and a second plurality of apertures arranged in a circular pattern having a second diameter. A plurality of repositional stops are further provided including mounting posts for securing the repositional stops within any of the first and second plurality of apertures. | 2013-02-07 |
20130035212 | Stationary exercise device - An exercise device includes an upright post extended upwardly from a base, a pair of connecting members pivotally coupled to the upright post with an axle, two wheels rotatably attached to the axle, two lower brake arms and two upper brake arms pivotally attached to the upright post and each having a brake shoe for engaging with the wheels, a bar engaged with the free ends of the lower brake arms, and a follower engaged with the free ends of the upper brake arms and adjustable toward and away from the bar for adjusting a resistive force of the brake shoes onto the wheels and for adjusting the resistive force to the swinging movement of the handles and the elliptical movement of the foot supports. | 2013-02-07 |
20130035213 | Portable Leg Exerciser - A compact leg exerciser includes two portions rotatable about a hinge. Each portion includes a base and a foot pedal displaceable along the base. The pedals include stops located longitudinally inward of the wheels. Each base is provided with resilient limiters for contacting against the stops of the pedals to limit travel of the pedals and thereby prevent the pedals from contacting the longitudinal ends of the periphery. The hinge is offset from the sides of each base and forms a handle for transporting the leg exerciser when the exerciser is folded about the hinge into a closed position. | 2013-02-07 |
20130035214 | CUSHIONING MECHANISM OF A TREADMILL - A cushioning mechanism of a treadmill is interposed with an auxiliary plate between a base frame and the running board. The cushioning mechanism | 2013-02-07 |
20130035215 | TREADMILL WITH FOOT FALL MONITOR AND CADENCE DISPLAY - In general, the present invention discloses treadmills that include a monitor that detects foot falls of a person exercising on the treadmill. Various mechanisms are described that can be incorporated on a treadmill to detect foot falls. For example, load cells, vibration monitors, motor load variance monitors, and sound monitors can be used to detect foot falls. A processing unit on the treadmill can receive data from the foot fall monitor to calculate a cadence, or a number of foot falls per unit time. Information relating to cadence can be displayed to the person exercising. In addition to a foot fall monitor, the present invention also discloses a monitor that detects foot lifts of a person exercising on a treadmill. A processing unit can receive data from the foot fall and foot lift monitors to determine and display stride length. | 2013-02-07 |
20130035216 | ROWING MACHINE SIMULATOR - One aspect is a rowing machine with a longitudinally extending beam and a seat mounted to said beam and slidable therealong. A frame is mounted to said beam and slidably movable therealong independently of said seat. A pair of foot rests are mounted to a user end of said frame. A flywheel is rotatably mounted by a flywheel shaft to said frame, said flywheel shaft mounted to said frame a height less than a radius of said flywheel above said beam. The flywheel is drivable by a cable through a transmission mechanism mounted to said frame such that one end of said cable remote from said flywheel is connected to a handgrip and the other end of said cable connected to a cable take up mechanism. | 2013-02-07 |
20130035217 | MUSCLE STRETCHING AND MASSAGING APPARATUS - A muscle stretching and massaging apparatus enables stretching of the calf at varying levels of intensity and massaging of muscles of the leg while those muscles are in a relaxed state. A support frame provides a stable base for the apparatus and means for receiving and supporting a lateral roller at a plurality of heights and a stretch board at a plurality of angles relative to a supporting surface. The stretch board enables calf stretching at varying levels of intensity, depending on the severity of the angle formed between the stretch board and the surface upon which the support frame rests. The adjustable height of the roller further enables the apparatus to provide calf and hamstring massaging while the muscles are in a relaxed state. | 2013-02-07 |
20130035218 | DUAL GRIP BARBELL - An exercise barbell comprises two separated pairs of rings, all lying along the length of the barbell in a common plane, each ring rotatably supporting a handle member which bisects the ring. The members of each pair are closely separated at their edges, or abutting one another, and are connected by very short bars extending on opposite sides of the center line of the bar. The two pairs are separated by a pair of longer bars disposed on opposite sides of the center line of the bar. Shafts extend outwardly along the length of the barbell from the outermost ring of each pair and these extending shafts may be rotatable, for gripping by the exerciser, and can support individual weights with center holes for surrounding the bar. The dual sets of handles allow a variety of different exercises to be performed with the barbell, most commonly by a user gripping the handle supported in either the two innermost rings or the two outermost rings of each pair. | 2013-02-07 |
20130035219 | EXERCISE DEVICE FOR GENERATING VIBRATION - An exercise device for generating vibration is provided. The device includes a body that is attachable to exercise equipment through a pair of attachment mechanisms coupled to the body. One of the pair of attachment mechanisms is attachable to a cable of the exercise equipment and the other of the pair of attachment mechanisms is attachable to an accessory for the exercise equipment. A vibrational assembly is positioned within the body and includes a rotatable shaft having a weight attached thereto. The rotatable shaft rotates the weight to generate vibrations in the body, wherein the vibrations in the body generate vibrations in the accessory for the exercise equipment. | 2013-02-07 |
20130035220 | MULTI-POSITION RESISTANCE TUBE EXERCISE APPARATUS - A wall-mounted multi-position pulley-based resistance tube exercise apparatus having resistance tube length effectively doubled for increased range of consistent resistance, and having a height adjustable pulley assembly providing a user with the ability to set multiple exercise initiation points so as to provide exercise options for a full body workout at a single exercise station. | 2013-02-07 |
20130035221 | APPARATUS AND METHOD FOR SLICING FOOD PRODUCTS - An apparatus for slicing food products includes a cutting blade which moves in a cutting plane to cut off slices from at least one product supplied to the cutting plane and includes a blade changing device which is designed to replace the cutting blade automatically with a replacement cutting blade on the presence of a change criterion. | 2013-02-07 |
20130035222 | METHODS AND APPARATUS FOR APPLICATION OF NESTED ZERO WASTE EAR TO TRAVELING WEB - The present invention provides a method of providing a disposable product with zero waste ear formation and attaching the ears to a running chassis web. | 2013-02-07 |
20130035223 | System and Method for the Continuous Extraction of a Liquid Phase of Microsamples, and Automated Installation for Taking Them, For Carrying Out the Extraction and Taking Measurements - A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled. | 2013-02-07 |
20130035224 | Method for Making an Aluminum Nitride Substrate - Disclosed is a method for making an aluminum nitride substrate. At first, aluminum nitride is mixed with a carbonized material. The mixture is made into mixture powder in a granulation process. The mixture powder is sintered at an appropriate temperature so that the carbonized material reacts with oxygen to produce a gaseous carbon compound. The gaseous carbon compound is released, and hence an aluminum nitride substrate is made. Before the making of the aluminum nitride substrate is made, the aluminum nitride powder is mixed with the carbonized material. For the stable heat dispersion of the carbonized material, the heating is even during the sintering. The purity of the aluminum nitride substrate is high, the quality of the aluminum nitride substrate is good, and the size of the aluminum nitride substrate is large. Hence, the yield of the making of the aluminum nitride substrate is high. | 2013-02-07 |
20130035225 | ORGANIC/INORGANIC HYBRID CATALYTIC MATERIALS, THEIR PREPARATION, USE IN SELECTIVE PROCESSES AND REACTORS CONTAINING THEM - A low cost, viable and modular method to prepare new, highly selective catalytic materials, especially “catalytic membranes”, is described. A method for the engineering and use of various types of reactors based on these catalytic membranes, even in a one-pot procedure, is also disclosed. The catalytic membranes are versatile, in terms of variety of chemical reactions promoted, and can be easily reused with negligible catalysts leaching. They are particularly useful, but not limited to, the asymmetric hydrogenation of substituted α,β unsaturated acids or esters. | 2013-02-07 |
20130035226 | METHOD FOR PRODUCING CATALYST - This invention is intended to improve the coverage of a platinum or platinum alloy surface with gold when producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys. The invention provides a method for producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys comprising a step of gold reduction comprising adding carrier particles that support platinum or platinum alloys, a reducing agent, and a gold precursor to a liquid medium and mixing the same, wherein the reducing agent is added to adjust the ORP value (i.e., an oxidation-reduction potential with reference to the silver-silver chloride electrode) of the liquid medium to −630 to +230 mV upon completion of addition. | 2013-02-07 |
20130035227 | Procatalyst Composition with Substituted 1,2-Phenylene Aromatic Diester Internal Donor and Method - Disclosed are procatalyst compositions having an internal electron donor which include a substituted phenylene aromatic diester and optionally an electron donor component. Ziegler-Natta catalyst compositions containing the present procatalyst compositions exhibit high activity and produce propylene-based olefins with broad molecular weight distribution. | 2013-02-07 |
20130035228 | CATALYST PRODUCTION METHOD AND CATALYST PRODUCTION APPARATUS, AND METHOD FOR CONTROLLING CHARACTERISTICS OF REACTION LAYER FOR FUEL CELL USING THE CATALYST - The present invention is directed to improving a catalyst applied to a reaction layer having a structure (PFF structure) in which a polymer electrolyte phase surrounds a periphery of a catalyst with a hydrophilic region interposed therebetween and reducing the amount of catalyst metal particles used. | 2013-02-07 |
20130035229 | FUNGICIDAL MIXTURES I COMPRISING QUINAZOLINES - The present invention relates to fungicidal mixtures, comprising at least one quinazo-line compound I and one compound II as defined in the description, and to compositions comprising these mixtures. | 2013-02-07 |
20130035230 | USE OF FUNGAL ORGANISM PYTHIUM OLIGANDRUM - The invention concerns the application of the fungal organism | 2013-02-07 |
20130035231 | ANNUAL BROME CONTROL USING A NATIVE FUNGAL SEED PATHOGEN - Formulations having a selective, mycoherbicide activity for killing ungerminated seeds of invasive grass species are provided. An agricultural, mycoherbicide formulation is taught for killing ungerminated seeds of invasive grass species. The formulations can comprise, for example, a slow-growing strain of | 2013-02-07 |
20130035232 | INDUCTION AND STABILIZATION OF ENZYMATIC ACTIVITY IN MICROORGANISMS - Provided herein are methods for inducing and stabilizing an enzyme activity. Optionally, the enzyme is in a microorganism capable of producing the enzyme. In some embodiments, the enzyme can be nitrile hydratase, amidase, or asparaginase I. Provided are compositions comprising enzymes or microorganisms having induced and/or stabilized activity. Also provided are methods of delaying a plant development process by exposing a plant or plant part to the enzymes or microorganisms having induced and/or stabilized activity. | 2013-02-07 |
20130035233 | NOVEL HERBICIDE RESISTANCE GENES - The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities. | 2013-02-07 |
20130035234 | HERBICIDE COMPOSITION HAVING IMPROVED EFFECTIVENESS, METHOD OF PREPARATION AND USE - Herbicide composition containing at least one herbicide from the family of phenoxyalkanoic acids in acid form and/or a benzoic acid derivative, and at least one solvent or oil, characterised in that the composition includes at least one surfactant and contains from 0 to 5% by mass of water. | 2013-02-07 |
20130035235 | POLYURETHANE DISPERSIONS FOR SEALING THE TEATS OF THE MAMMARY GLANDS IN MILKING ANIMALS - The present invention relates to aqueous polyurethane dispersions for sealing teats of animal mammary glands. | 2013-02-07 |
20130035236 | Fluorinated Precursors of Superconducting Ceramics, and Methods of Making the Same - This invention provides a method of making a fluorinated precursor of a superconducting ceramic. The method comprises providing a solution comprising a rare earth salt, an alkaline earth metal salt and a copper salt; spraying the solution onto a substrate to provide a film-covered substrate; and heating the film-covered substrate in an atmosphere containing fluorinated gas to provide the fluorinated precursor. | 2013-02-07 |
20130035237 | Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing - The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research. | 2013-02-07 |
20130035238 | METHOD FOR GENOME COMPLEXITY REDUCTION AND POLYMORPHISM DETECTION - The present invention provides methods to produce a reduced representation of a genome for sequencing and DNA polymorphism detection. In particular, the invention provides PCR-based methods, with normalization of the amplified products using a duplex-specific nuclease, in order to reduce over-representation of PCR products. Oligonucleotides for use in the disclosed method are also provided. | 2013-02-07 |
20130035239 | FILTERING SMALL NUCLEIC ACIDS USING PERMEABILIZED CELLS - Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described. | 2013-02-07 |
20130035240 | Markers for Obesity and Methods of Use Thereof - Markers for obesity, particularly childhood obesity, are provided along with methods of use thereof. | 2013-02-07 |
20130035241 | KEY GENES, MICRORNAS, OTHER NON-CODING RNAS AND COMBINATION THEREOF FOR IDENTIFYING AND REGULATING THE PLURIPOTENT STATUS OF CELLS - Key genes, microRNAs, other non-coding RNAs and a combination thereof for identifying and regulating pluripotency of cells are provided. The key genes, microRNAs, other non-coding RNAs and a combination thereof are highly expressed in full pluripotent stem cells but are significantly suppressed or silenced in partially pluripotent stem cells. The genes, microRNAs and other non-coding RNAs are those of a chromosome imprinted Dlk1-Dio3 region located on the long arm of mouse chromosome 12, and are homologous genes, microRNAs and other non-coding RNAs having 70-100% homology with them in genomic syntenic regions of other mammals. Also provided are uses of the genes, microRNAs, other non-coding RNAs and combination thereof in identifying the pluripotent status of stem cells and regulating pluripotency of cells; in typing stem cells; regulating pluripotency of cells, pluripotent states and levels of cells; treating diseases; and developing drug targets for tumor treatment and antitumor drugs. | 2013-02-07 |
20130035242 | HIGH THROUGHPUT SAMPLE ANALYZER - A sample processing system ( | 2013-02-07 |
20130035243 | KLF6 ALTERNATIVE SPLICE FORMS AND A GERMLINE KLF6 DNA POLYMORPHISM ASSOCIATED WITH INCREASED CANCER RISK - Disclosed are methods of identifying and diagnosing certain types of cancers and pre-stages thereof in a patient by identifying alternatively spliced isoforms of wild type KLF6 (KLF6wt), in particular any one of the isoforms selected from the group consisting of: KLF6 splice variant-1 (KLF6 | 2013-02-07 |
20130035244 | Method for Characterising a Molecule - The invention relates to a method for characterising three-dimensional objects, including steps comprising: i) generating a three-dimensional reconstruction of a three-dimensional object; ii) generating a mesh of the object, said mesh being made up of points connected two-by-two by a ridge; iii) characterising the points and/or faces of the mesh of the object according to the statuses of remarkable properties at said points; iv) splitting the object into contiguous three-dimensional regions based on the mesh and the characterisation of the points thereof; v) creating a database of regions that represent objects of an environment; and/or vi) screening a region on a database in order to find objects that contain similar and/or complementary regions; and/or vii) inferring functions of the objects according to similarities in the regions thereof; and/or viii) inferring interactions between objects by complementarity of the regions thereof; and/or ix) specifying the frequency of a region in an environment. | 2013-02-07 |
20130035245 | INORGANIC-BINDING PEPTIDES AND QUALITY CONTROL METHODS USING THEM - The present invention relates to quality control methods using inorganic binding peptides, wherein inorganic entities are identified using inorganic-binding peptides specifically binding to the inorganic entity of interest. In particular, the invention includes a method for the identification of defects or inhomogeneities on a surface by detecting an inorganic entity of interest. It further includes a method for the isolation of powder particles comprising an inorganic entity of interest from a mixture of powder particles. In addition, the present invention relates to inorganic-binding peptides comprising the amino acid sequence MTWDPSLASPRS (SEQ ID NO: 31) and the amino acid sequence LNAAVPFTMAGS (SEQ ID NO: 32), respectively. | 2013-02-07 |
20130035246 | Method and Apparatus for Determining a Mammal's Exposure to Chemical or Biological Agents - Cellular immunologic methods are disclosed for determining human health effects of exposures to environmental molds and toxins. In one embodiment, a method for assessing a patient's exposure to a mold strain is provided. The method comprises measuring cytokine production in at least the peripheral blood mononuclear cells of a mammal suspected of being exposed to mold or other toxin and determining if there is a decreased production of cytokines in the mammal suspected of being exposed to mold or other toxin when compared to the production of cytokines produced in a mammal not suspected of being exposed to mold or other toxin. Other methods, including methods of diagnosing respiratory disorders, including asthma, are also disclosed. | 2013-02-07 |
20130035247 | GLOBAL DNA HYPOMETHYLATION AND BIOMARKERS FOR CLINICAL INDICATIONS IN CANCER - The present invention provides methods of determination of a global DNA methylation index (GDMI) in a sample from a subject, using a variety of methods which can detect global, genome-wide, and gene-specific DNA methylation to create methylation portraits that can be used for early detection, diagnosis, and clinical management in the personalized medicine space. Further, the invention provides methods of diagnosis of cancer, including gastric cancer and hepatocellular cancer in a subject, by comparing the GDMI in a sample obtained from a subject to the methylation index of standard controls. These methods allow diagnosis of gastric carcinoma and liver cancer in patients who may be asymptomatic or have inconclusive pathology, and allowing earlier treatment of the subject. | 2013-02-07 |
20130035248 | Microsporidia Detection System and Method - In various aspects, a multiplex primer set, a kit for performing an assay to detect microsporidia, and a method of identifying a microsporidia in a sample is provided. The multiplex PCR primer set including SEQ ID NOS 1-4. The kit includes a multiplex PCR primer set having SEQ ID NOS 1-4 and a set of probes having SEQ ID NOS 5-8. In the method a sample is obtained and a multiplex PCR assay is performed on the sample. A multiplex PCR primer set including SEQ ID NOS 1-4 is included in the multiplex PCR assay. The sample is determined to have the microsporidia in response to the multiplex PCR assay amplifying a target sequence associated with microsporidia. | 2013-02-07 |
20130035249 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CEA-EXPRESSING CANCERS - Provided are improved methods and compositions for detecting, monitoring and/or treating a CEA-expressing cancer. | 2013-02-07 |
20130035250 | NON-INVASIVE METHOD FOR DIAGNOSIS OF PROSTATE CANCER - The present invention relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer comprising the analysis of the expression of the marker gene hepsin in an urine sample. It further relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer by determining the expression levels of the marker genes hepsin, EZH2, prostein and PCA3. | 2013-02-07 |
20130035251 | miRNA FINGERPRINT IN THE DIAGNOSIS OF WILMS' TUMOUR - MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 2013-02-07 |
20130035252 | METHODS FOR DETERMINING A GENE EXPRESSION PROFILE AND FOR DISEASE DIAGNOSIS - The invention generally relates to methods for determining a gene expression profile and for disease diagnosis. In certain aspects, methods of the invention involve obtaining a sample including somatic cells, transforming the somatic cells into target cells, and determining an expression profile from the target cells. | 2013-02-07 |
20130035253 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. | 2013-02-07 |
20130035254 | DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) - The present invention relates to methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject. Particularly, the present invention relates to a specific antibody profile useful in diagnosing SLE in a subject. | 2013-02-07 |
20130035255 | CONTROLLED RELEASE HYBRID SYSTEMS - Described herein are controlled release hybrid systems and methods of use thereof. In certain embodiments, the controlled release hybrid systems can be used to screen for interactions between candidate molecules. In addition, these controlled release hybrid systems can be modified to screen for chemical inhibitors of interacting candidate molecules. In another embodiment, the controlled release hybrid systems described herein can be modified to screen for mutant molecules (e.g., peptides, proteins, polypeptides, portions of proteins, portions of polypeptides, or any combination thereof) when compared to candidate molecules that were previously shown to interact. Upon identifying these mutant molecules, the controlled release hybrid systems can be further utilized to identify peptide, chemicals, or a combination thereof that potentially act as inhibitors of these mutant molecules. In this embodiment, the controlled release systems can be readily modified for personalized medication applications. | 2013-02-07 |
20130035256 | Chimeric Polypeptides Useful in Proximal and Dynamic High-Throughput Screening Methods - The present invention provides a method of high-throughput screening (HTS) of active agents of a cell-surface G-Protein coupled receptor (GPCR) or another target receptor of interest. The method uses a non-invasive, sensitive reporting system that is proximal to the target of interest, combined with a dynamic, automated screening procedure so as to detect orthosteric ligands, such as agonists and antagonists, but is also suitable to detect allosteric or low affinity active agents of a GPCR and possibly other disease-related receptors. | 2013-02-07 |
20130035257 | MICROFLUIDIC ARRAYS AND METHODS FOR THEIR PREPARATION AND USE - Methods of isolating at least one cell of interest, methods of making fixed arrays, arrays comprising a glass substrate bonded to a patterned siloxane structure having inlets, outlets and microchannels, array kits, and methods of making microfluidic apparati are provided in the present application. | 2013-02-07 |
20130035258 | LUMINESCENT TETRAPODS DOTS AND VARIOUS APPLICATIONS - A tetrapod article and its uses are disclosed whereby such tetrapod article comprises an apex base nanomaterial and X leg base nanomaterial protruding from the apex, wherein X is an integer. In an aspect, the tetrapod article can comprise Y nanomaterial layers overcoating the apex base material and the leg base nanomaterial protruding from the apex, wherein Y is an integer. In yet another aspect, disclosed is an assay kit comprising a set of hydrophobic coated tetrapod articles coupled to K pairing moieties that are paired to L predefined targeting items to form a set of tetrapod conjugates that that correspond to M biological parameters and luminesce at respective wavelengths that correspond to the respective predefined target cell types, wherein K, L, and M are integers. | 2013-02-07 |
20130035259 | Methods and/or Systems Producing and Providing Sets of Oligonucleotide Conjugates for Assays and Detections - The present disclosure is directed to methods and/or systems producing and providing uses sets of oligonucleotide conjugates for assays and detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein. | 2013-02-07 |
20130035260 | GENES INVOLVED IN INFLAMMATORY BOWEL DISEASES AND USE THEREOF - The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The invention also concerns methods for diagnosing inflammatory diseases. | 2013-02-07 |
20130035261 | USE OF N-ALKYL IMIDAZOLE FOR SULFURIZATION OF OLIGONUCLEOTIDES WITH AN ACETYL DISULFIDE - A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources. | 2013-02-07 |
20130035262 | Integrated Computational Element Analytical Methods for Microorganisms Treated with a Pulsed Light Source - Determining the microorganism load of a substance may be conducted readily using one or more integrated computational elements. By determining a substance's microorganism load, the substance's suitability for a variety of applications may be ascertained. Methods for determining the microorganism load of a substance using one or more integrated computational elements can comprise: providing a substance comprising a plurality of viable microorganisms; exposing the substance to a pulsed light source for a sufficient length of time to form at least some non-viable microorganisms; and determining a microorganism load of the substance using one or more integrated computational elements. | 2013-02-07 |
20130035263 | AGENT AND COMPOSITION FOR OILFIELD APPLICATIONS - An agent for oilfield applications capable of being dispersed in water is nanofibrillar cellulose. The nanofibrillar cellulose mixed in water gives shear-thinning behavior to the composition, which is pumped to a subterranean oil-containing formation to aid in oil recovery. | 2013-02-07 |
20130035264 | Constraining Pyrite Activity in Shale - Degeneration of shale caused by oxygen in aqueous drilling, fracturing and completion fluids is minimized by introducing imidazolines modified so that they will be attracted efficiently to pyrites in the shale, thereby forming a protective coating on the pyrites. Inhibiting oxidation of the pyrites sharply reduces physical degradation of the shale in the presence of drilling, fracturing and completion fluids carrying oxygen. The imidazoline is an ionic salt or a beatine. | 2013-02-07 |
20130035265 | Methods for Treating Fibers - Fiber bundles are prepared by affixing at least two fibers with a binding agent. The binding agent is designed such that the fiber bundles remain intact as the fiber bundles are mixed with and suspended in a fluid. After the fiber bundles exit the mixing apparatus, the binding agent degrades and releases the individual fibers. This allows higher concentrations of fibers to be added to fluids without fouling the mixing apparatus. | 2013-02-07 |
20130035266 | COALESCENCE OF EMULSIONS - The invention relates to methods of controlling the stability of emulsions to coalescence and phase separation. Use of chaotropic counterions to promote coalescence and/or phase separation of emulsions stabilized by ionic surfactants is described. | 2013-02-07 |
20130035267 | USE OF WATER-BASED LUBRICANTS FOR TEXTILE MACHINES - The present invention relates to water-based lubricants for textile machines, especially to such lubricants for use as needle oil and/or lifter oil as well as the use thereof as a needle oil and/or lifter oil. | 2013-02-07 |
20130035268 | LUBRICANT COMPOSITIONS WITH IMPROVED OXIDATION STABILITY AND SERVICE LIFE - Provided are lubricants containing a synthetic ester, one or more additional base stocks and an additive package along with methods of making and using the same. Lubricant compositions comprise a synthetic ester that is a reaction product of at least one hindered organic polyol with one or more carboxylic acid where at least some (20%) up to 100% of the acids are branched. The lubricant compositions can provide improved oxidation stability and extended service life, as compared to a lubricant whose ester component is the reaction product of one or more hindered organic polyols and one or more carboxylic acids that are all linear, in applications that involve exposure to air, moisture, and/or high temperatures. These lubricant compositions are suited to a variety of lubricant applications, including, but not limited to air compressors, gear boxes, bearing sets, hydraulic systems, and chain drives. | 2013-02-07 |
20130035269 | COMPOSITIONS FOR AND METHODS OF LUBRICATING CARCASS CONVEYOR - An improved lubricant for use with a conveyor in a meat packing plant meeting the requirements of (1) adequate lubricity, (2) “drip-resistance,” (3) safety, (4) rust resistance, (5) economy of manufacture and use, and (6) the ability to be removed by cleaning methods is provided by preparing a mixture of mineral oil, a fatty acid, a silicone oil, and a polybutene, each being acceptable for incidental contact with food, in certain minimum amounts and increasing the amounts of one or more of said components such that the improved lubricant has a viscosity of 20-160 centipoise. A method of improving a lubricant for use on a conveyor in a meat packing plant and a method of lubricating the conveyor are also disclosed. | 2013-02-07 |
20130035270 | Friction Reducing Additive - An automotive engine oil and/or fuel comprising a base stock and an organic polymeric friction reducing additive is claimed. A method of reducing friction in an automotive engine oil and/or fuel by the addition of the organic polymeric friction reducing additive to the base stock is also claimed. | 2013-02-07 |
20130035271 | ESTERS FROM SOLID POLYOLS AND UNSATURATED CARBOXYLIC ACIDS - The present invention relates to a process for the preparation of an ester from a polyol which is solid at 25° C. and a carboxylic acid component which contains at least 50 wt. % of at least one mono- or polyunsaturated aliphatic carboxylic acid, based on the total weight of the carboxylic acid component, in a reactor under reduced pressure. The invention also provides a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions. | 2013-02-07 |
20130035272 | NOVEL NITRILE AND AMIDOXIME COMPOUNDS AND METHODS OF PREPARATION FOR SEMICONDUCTOR PROCESSING - Semiconductor processing compositions comprising amidoxime compounds having two or more amidoxime functional groups and their use in semiconductor processing to remove photoresist, polymeric materials, etching residues and copper oxides from semiconductor substrates, particularly substrates comprising copper, low-k dielectric material, titanium nitride, and/or titanium oxynitride. | 2013-02-07 |
20130035273 | COMPOSITION CONTAINING A POLYSACCHARIDE HYBRID POLYMER AND METHODS OF CONTROLLING HARD WATER SCALE - A composition includes a polysaccharide hybrid polymer and 2-phosphonobutane-1,2,4-tricarboxylic acid. In one embodiment, the polysaccharide hybrid polymer includes a polysaccharide residue present in an amount between approximately 30% to 80% by weight of the polysaccharide hybrid polymer and a residue of acrylic acid, methacrylic acid or a combination thereof present in an amount between approximately 5% to 75% by weight of the polysaccharide hybrid polymer. | 2013-02-07 |
20130035274 | CLEANING COMPOSITION CONTAINING A POLYSACCHARIDE HYBRID POLYMER COMPOSITION AND METHODS OF CONTROLLING HARD WATER SCALE - A composition includes an anionic polysaccharide hybrid polymer composition and 2-phosphonobutane-1,2,4-tricarboxylic acid. In one embodiment, the polysaccharide hybrid polymer composition includes a polysaccharide residue present in an amount from approximately 5% to approximately 90% by weight of the polysaccharide hybrid polymer composition and a residue of at least one ethylenically unsaturated monomer present in an amount from approximately 10% to approximately 75% by weight of the polysaccharide hybrid polymer composition. | 2013-02-07 |
20130035275 | CLEANING COMPOSITION CONTAINING A POLYSACCHARIDE GRAFT POLYMER COMPOSITION AND METHODS OF IMPROVING DRAINAGE - A composition includes a polysaccharide graft polymer composition. In one embodiment, the polysaccharide graft polymer composition includes a polysaccharide residue present in an amount from about 5% to about 90% by weight of the polysaccharide graft polymer composition and a residue of at least one ethylenically unsaturated monomer present in an amount from about 10% to about 75% by weight of the polysaccharide graft polymer composition. | 2013-02-07 |
20130035276 | CLEANING COMPOSITION CONTAINING A POLYSACCHARIDE GRAFT POLYMER COMPOSITION AND METHODS OF CONTROLLING HARD WATER SCALE - A composition includes a polysaccharide graft polymer composition and 2-phosphonobutane-1,2,4-tricarboxylic acid. In one embodiment, the polysaccharide graft polymer composition includes a polysaccharide residue present in an amount from approximately 5% to approximately 90% by weight of the polysaccharide graft polymer composition and a residue of acrylic acid, methacrylic acid or a combination thereof present in an amount from approximately 10% to approximately 75% by weight of the polysaccharide graft polymer composition. | 2013-02-07 |
20130035277 | CLEANING COMPOSITION CONTAINING A POLYSACCHARIDE HYBRID POLYMER COMPOSITION AND METHODS OF IMPROVING DRAINAGE - A composition includes a polysaccharide hybrid polymer composition. In one embodiment, the polysaccharide hybrid polymer composition includes a polysaccharide residue present in an amount from about 5% to about 90% by weight of the polysaccharide hybrid polymer composition and a residue of at least one ethylenically unsaturated monomer present in an amount from about 10% to about 75% by weight of the polysaccharide hybrid polymer composition. | 2013-02-07 |
20130035278 | Cyclohexene Derivatives and Their Use as Odorants - The present invention relates to a process for the production of formyl cyclohexene derivatives which are suitable as odorants as such or as intermediates for the preparation of further odorants. In particular the present invention relates to a domino-methylenation-Diels-Alder reaction of α,β-unsaturated aldehydes using formaldehyde in the presence of 1,3-butadienes | 2013-02-07 |
20130035279 | METHOD AND A SYSTEM FOR PRODUCING THERMOLABILE NANOPARTICLES WITH CONTROLLED PROPERTIES AND NANOPARTICLES MATRICES MADE THEREBY - This disclosure relates to a method and a system of producing nanoparticles and nanoparticle matrices of thermolabile, biocompatible matrix materials, like lipids and biopolymers with controlled properties. A prototype pulse-heat aerosol system is described for single-step production of free, thermolabile nanoparticles with sufficient control over size, morphology and crystallinity with controlled-release properties, for possible therapeutic, cosmetic or diagnostic use. Nanoparticles of the range 50 to 500 nm are obtained and are found suitable for controlled drugs delivery. | 2013-02-07 |
20130035280 | Method and means for identifying substances which inhibit IgE production - The invention relates to the field of biomedical and pharmacological research, in particular to the area of immunology, allergies and autoimmune diseases. The inventors have shown that SWAP-70 is a higher-level regulator for STAT-6 and BCL-6, the regulator being specific for IgE production in B-cells by amplifying the effect of STAT-6 and antagonizing the effect of BCL-6. The inventors have observed no influence of SWAP-70 on the expression of other genes that are likewise regulated by STAT-6 and/or BCL-6. In summary, it can be concluded that SWAP-70 positively regulates IgE production by shifting the interaction of the two antagonists STAT-6 and BCL-6 with regulatory elements of the IgE gene in favor of the activator STAT-6. Based on said findings, the invention provides a screening method which allows for identifying novel active agents that specifically inhibit IgE production. The substances identified by the method according to the invention are particularly suited for treating IgE-induced allergies and IgE-dependent autoimmune diseases. | 2013-02-07 |
20130035281 | PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF - The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and a GLP-1 receptor agonist which is suitable in the treatment or prevention of diabetes mellitus, impaired glucose tolerance, hyperglycemia or other conditions. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions. | 2013-02-07 |
20130035282 | METABOLIC AND CARDIOPROTECTION BY THE MYOKINE FOLLISTATIN-LIKE 1 POLYPEPTIDE - Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and derivatives or variants thereof can be used to treat or prevent metabolic diseases or disorders and to treat or prevent cardiac damage caused by interrupted cardiac muscle blood supply. | 2013-02-07 |
20130035283 | ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT - The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis. | 2013-02-07 |
20130035284 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES - The present invention concerns methods and compositions involving small molecule inhibitors for the treatment or prophylaxis of flavivirus infection, such as dengue virus and West Nile virus. | 2013-02-07 |
20130035285 | NOVEL GLUCAGON ANALOGUES - The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity. | 2013-02-07 |
20130035286 | Pharmaceutical Composition Comprising Cyclic Somatostatin Analogues - The present invention describes parenteral pharmaceutical compositions comprising a somatostatin analogue and novel somatostatin analogues. | 2013-02-07 |
20130035287 | TRANSIENT IMMORTALIZATION - The invention relates to a method for transiently immortalizing cells according to which immortalization proteins are introduced into the cells from outside. The invention also relates to a method for producing cells according to which organ-related cells are transiently immortalized by the exogenous supply of immortalization proteins and are remortalized after their expansion. The invention further relates to the cells produced according to the inventive method, to the use of said cells for producing a transplant and to the immortalization proteins used in the method. | 2013-02-07 |
20130035288 | Resorption Enhancers As Additives To Improve The Oral Formulation Of Non-Anticoagulant Sulfated Polysaccharides - Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) in combination with a gastrointestinal epithelial barrier permeation enhancer is orally administered to a subject in a manner sufficient to enhance blood coagulation in the subject. Compositions and kits for practicing methods of the invention are also described. | 2013-02-07 |
20130035289 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF THROMBOSIS-RELATED DISEASES COMPRISING A FRAGMENT OF PROLACTIN (PRL)-GROWTH HORMONE (GH)-PLACENTAL LACTOGEN (PL)-FAMILY PROTEIN - The present disclosure relates to a pharmaceutical composition for use in the preventive and/or therapeutic treatment of thrombosis-related diseases or conditions relating to high level of plasminogen activator inhibitor 1 (PAI-1) expression, which composition comprises: A) a fragment of a polypeptide or protein of prolactin (PRL)-growth hormone (GH)-placental lactogen (PL)-family and homologous derivatives thereof, which fragment comprises from 6 to 14 consecutive amino acid residues of the amino acid sequence having general formula (I); or B) a peptide or a recombinant protein comprising said peptide, wherein the peptide is from 6 to 50 amino acids in length and has the activity to inhibit PAI-1, said peptide comprising from 6 to 14 consecutive amino acid residues of the amino acid sequence of general formula (I); or C) a polynucleotide encoding said fragment of a polypeptide or protein of A) or said peptide or recombinant protein of B). | 2013-02-07 |
20130035290 | Chitinase-3-Like Protein 1 as a Biomarker of Recovery from Kidney Injury - The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/Brp-39/YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney. | 2013-02-07 |
20130035291 | OBTAINMENT OF BIOACTIVE PRODUCTS FROM COCOA HAVING INHIBITORY ACTIVITY AGAINST THE PEP ENZYME AND ANTIOXIDANT AND/OR ANTINEURODEGENERATIVE ACTIVITY - The present invention relates to the production of bioactive products from raw plant matter, namely cocoa extracts. The said products have one or more biopeptides with prolyl endopeptidase (PEP) enzyme inhibitory activity in vitro and/or antioxidant and/or antineurodegenerative capacity in vivo and can be used in dietetics and in the food and pharmaceutical industries. | 2013-02-07 |
20130035292 | NMDA Receptors Modulators and Uses Thereof - Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. | 2013-02-07 |
20130035293 | COMPOSITIONS AND METHODS FOR MODULATING DOPAMINE NEUROTRANSMISSION - The present invention provides for diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurotransmission. Agents of the present invention include fragments of D2 receptor or dopamine transporter (DAT) that can disrupt D2-DAT coupling. | 2013-02-07 |
20130035294 | Neuromedin and FN-38 Peptides for Psychotic Diseases - Methods and compositions for treating psychiatric diseases and disorders are disclosed. The methods provided generally involve the administration of an NMX peptide, an FNX peptide, or an NMX receptor agonist, or analogs or derivatives thereof, to a subject in order to treat psychiatric diseases and disorders, and conditions associated with psychiatric diseases and disorders. | 2013-02-07 |
20130035295 | Use of Peptide Epoxyketones for Metastasis Suppression - The invention provides a method of repressing metastasis of a cancer compromising the administration of a peptide epoxyketone proteasome inhibitor. Furthermore, the method can be performed in combination with the administration of one or more additional therapeutics | 2013-02-07 |
20130035296 | THERAPEUTIC PEPTIDES - The present invention provides a peptide, peptidomimetic or amino acid derivative having a net positive charge of at least +2 and incorporating a disubstituted β amino acid, each of the substituting groups in the β amino acid, which may be the same or different, comprises at least (7) non-hydrogen atoms, is lipophilic and has at least one cyclic group, one or more cyclic groups within a substituting group may be linked or fused to one or more cyclic groups within the other substituting group and where cyclic groups are fused in this way the combined total number of non-hydrogen atoms for the two substituting groups is at least (12), for use as a cytolytic therapeutic agent; as well as non therapeutic uses of these molecules and certain defined novel compounds from within this definition. | 2013-02-07 |