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06th week of 2014 patent applcation highlights part 58
Patent application numberTitlePublished
20140039102POLYSULFONE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF - This disclosure relates generally to polysulfone compositions whose residual phenolic monomers or phenolic degradation products exhibit little or no estradiol binding activity. Also disclosed are methods for making the disclosed polysulfones and articles of manufacture comprising the disclosed polysulfones.2014-02-06
20140039103BLENDS OF POLYPHENYLENE ETHER SULFONE AND SILICONE POLYESTER CARBONATE - Disclosed herein is a composition comprising a polyphenylene ether sulfone and a resorcinol based silicone aryl polyester carbonate copolymer wherein greater than or equal to 50 mol % of copolymer repeating units are ester units derived from resorcinol, based on the total molar amount of all repeating units in the polymer and wherein the blend has less than 1 weight percent polycarbonate, based on the total weight of the composition, has FAR 25.853 peak heat release of less than 60 KW/m2014-02-06
20140039104ALKYL(METH)ACRYLATE-BASED THERMOPLASTIC RESIN COMPOSITION AND THERMOPLASTIC RESIN WITH HIGH SCRATCH RESISTANCE AND LOW YELLOWNESS - Disclosed are an alkyl(meth)acrylate-based thermoplastic resin composition and a thermoplastic resin with modified scratch resistance and yellowness. The alkyl(meth)acrylate-based thermoplastic resin composition provides improved scratch resistance and low yellowness index while maintaining transparency, flowability, and impact strength, even when the total content of the vinyl cyan-based monomer contained in the resin composition is reduced to a level unattainable by conventional techniques, and the content of the alkyl(meth)acrylate-based monomer is increased.2014-02-06
20140039105METHOD OF MANUFACTURING FOOTWEAR USING ADHESIVE FILMS AND COMPOSITE OF ADHESIVE FILMS - Disclosed therein are a method of manufacturing footwear using adhesive films and a composite of the adhesive film, which can allow an outsole and a midsole to be simultaneously molded and formed through the steps of putting the midsole made of EVA foam and the outsole made of rubber into a mold, inserting an adhesive film between the midsole and the outsole, and applying high temperature and high pressure to the midsole and the outsole, thereby not needing to carry out a cleaning process, a primer coating process, and a bonding process when an outsole and a midsole are manufactured, not needing additional facilities for the cleaning and bonding processes, reducing unnecessary manpower, and improving working environments.2014-02-06
20140039106Two-Part Silicone Rubber Composition - A two-part curable liquid silicone rubber composition comprises a first liquid composition and a second liquid composition. The first and second liquid compositions are stored separately and yield, upon mixing, a silicone rubber forming composition. The silicone rubber composition comprises: (A) an alkenyl group-containing organopolysiloxane comprising (A-1) an organopolysiloxane having only a silicon-bonded alkenyl group at each molecular terminal and (A-2) an organopolysiloxane having from 1 to 4 silicon-bonded alkenyl groups in side molecular chains and containing not greater than 2.0 wt. % of alkenyl groups; (B) a calcium carbonate powder; (C) a hydrosilylation reaction catalyst; and (D) an organohydrogenpolysiloxane having silicon-bonded hydrogen atoms.2014-02-06
20140039107MULTIPLE-ACID-DERIVED METAL SOAPS INCORPORATED IN RUBBER COMPOSITIONS AND METHOD FOR INCORPORATING SUCH SOAPS IN RUBBER COMPOSITIONS - A composition includes a polymer matrix, a multiple-acid-derived metal soap, wherein the metal has an oxidation state of +3 or +4. An associated method for making a rubber composition includes the steps of: combining a solvent and a multiple carboxylic, phosphonic, phosphoric, sulfuric, or sulfonic acid, or mixtures thereof, and mixing to form solution A; adding a source of metal ions to solution A and mixing to form a product A, the metal being selected from the metals having an oxidation state of +3 or +4, whereby product A includes a multiple-acid-derived metal soap; and combining the multiple-acid-derived metal soap with a diene rubber. A method of making a tire component includes the steps of: combining a solvent and a multiple carboxylic, phosphonic, phosphoric, sulfuric, or sulfonic acid, or mixtures thereof, and mixing to form solution A; adding a source of metal ions to solution A and mixing to form a product A, the metal being selected from the metals having an oxidation state of +3 or +4, whereby product A includes a multiple-acid-derived metal soap; combining the multiple-acid-derived metal soap with a diene rubber; and molding and vulcanizing the rubber composition into a tire component.2014-02-06
20140039108METHOD FOR PRODUCING FLAME-RETARDANT THERMOPLASTIC ELASTOMER COMPOSITION - A method is provided for producing a flame retardant thermoplastic elastomer composition, wherein the method includes (1) a step of preparing a thermoplastic elastomer composition by dynamically vulcanizing a thermoplastic elastomer composition precursor containing (A) an ethylene-α-olefin-based copolymer rubber, (B) a propylene-based polymer and (C) a mineral oil-based softening agent in the presence of (D) a crosslinking agent, and (2) a step of kneading the thermoplastic elastomer composition, (E) a halogen-free flame retardant, (F) a zinc oxide, and optionally (G) a polyhydric compound.2014-02-06
20140039109TREATED INORGANIC PIGMENTS HAVING IMPROVED BULK FLOW AND THEIR USE IN COATING COMPOSITIONS - The disclosure provides a coating composition comprising a treated inorganic pigment, wherein the treated inorganic pigment comprises an inorganic pigment comprising a pigment surface area of about 30 to about 75 m2014-02-06
20140039110Polymer Food Packaging - A polyolefin composition comprising a predetermined amount of an ethylene inhibitor for binding 1-aminocyclopropane-1-carboxylic-acid (ACC) to reduce an amount of ACC available for an ethylene biosynthetic pathway. 2014-02-06
20140039111FLOORING PRODUCT HAVING REGIONS OF DIFFERENT RECYCLE OR RENEWABLE CONTENT - A flooring product comprises a heterogeneous design layer having multiple regions wherein two regions comprise compositions having different recycle content or renewable content. The thickness of the design layer may be greater than the dimensions of the regions or the regions may extending from the top surface of the layer to the bottom surface of the design layer. The heterogeneous layer may be composed of consolidated particles/chips which may contain a polyester binder system with a renewable component. Additionally, a method for making a heterogeneous layer having a target wt % recycle content or renewable content is also disclosed.2014-02-06
20140039112CURABLE COMPOSITION - Provided are a curable composition and its use. The curable composition can exhibit excellent processability and workability. The curable composition exhibits excellent light extraction efficiency, hardness, thermal and shock resistance, moisture resistance, gas permeability and adhesiveness, after curing. In addition, the curable composition can provide a cured product that exhibits long-lasting durability and reliability even under harsh conditions, and that does not cause whitening and surface stickiness.2014-02-06
20140039113Curable Composition - Provided are a curable composition and its use. The curable composition can exhibit excellent processibility and workability. The curable composition exhibits excellent light extraction efficiency, hardness, thermal and shock resistance, moisture resistance, gas permeability and adhesiveness, after curing. In addition, the curable composition can provide a cured product that exhibits long-lasting durability and reliability even under harsh conditions, and that does not cause whitening and surface stickiness.2014-02-06
20140039114Fiber-Reinforced Composite Material - There is provided a fiber-reinforced composite material is constituted by reinforcing fibers with an average fiber length of 5 mm to 100 mm and a thermoplastic resin, in which in a viscoelastic characteristic that is defined by following formulas (1) and (2), an average value in a range of −25° C. of the melting point of a matrix resin to +25° C. of the melting point of a matrix resin satisfies following formula (3):2014-02-06
20140039115SULFONIC ACID MONOMER BASED COMPOSITIONS - The present invention relates to a composition which comprises a stable aqueous dispersion of discrete polymer particles and a water-soluble dispersant adsorbed onto the surfaces of pigment particles, wherein the polymer particles comprise structural units of a sulfonic acid monomer or a salt thereof. The present invention addresses a need in the art by providing a way to improve the hiding efficiency of compositions containing pigment such as TiO2014-02-06
20140039116Heat-Seal Coating - Described herein is a heat-seal coating which, when going through the recycled paper making process, will readily break down without any major amount of by-product that needs to be landfilled; can be made into paper again; breaks down in a commercial composting facility; and decomposes into basic materials such as carbon dioxide, carbon monoxide and water. The heat seal coating or top coat comprises three components: (1) a barrier polymer; (2) a polymer that provides some barrier properties and softness to the formulation; and, (3) a heat-curable adhesive.2014-02-06
20140039117SULFONIC ACID MONOMER BASED COMPOSITIONS - The present invention relates to a composition comprising a water-soluble dispersant comprising structural units of a sulfonic acid monomer or a salt thereof and a co-monomer. The dispersant of the present invention addresses a need in the art by providing a way to improve the hiding efficiency of coatings compositions.2014-02-06
20140039118HYBRID MATRIX FOR FIBER COMPOSITE MATERIALS - A fiber composite material obtainable by (a) mixing the components of a multi-component agent immediately before use, wherein component A of the multi-component agent contains at least one compound having two or more isocyanate groups, component B of the multi-component agent contains at least one compound which has at least two reactive groups selected from hydroxyl groups, thiol groups, primary amino groups and secondary amino groups and is simultaneously free from epoxy groups, and at least one of the components of the multi-component agent contains at least one epoxide prepolymer, (b) introducing the resulting application preparation into a mold in which fibers and optionally further additives are present, the resulting mixture containing at least one latent hardener for epoxide prepolymers, (c) pre-curing the resulting mixture at a temperature from 5° C. to 90° C., and (d) then finally curing the pre-cured fiber composite material at temperatures from 100° C. to 240° C., wherein the fiber composite material being removed from the mold after step (c) or step (d).2014-02-06
20140039119ABRASION RESISTANT COATINGS - A polyurethane or polyurea coating composition for use in protecting a leading edge substrate on an airfoil, such as aircraft wings, rotor blades and propeller blades, against liquid or solid particle erosion, the composition made from an isocyanate-terminated prepolymer and curing agents, such as polyaspartic esters, aldimines and ketimines.2014-02-06
20140039120POLYAMIDE AND POLYAMIDE COMPOSITION - (Problems to be solved)2014-02-06
20140039121Preparation of Polyphosphazene Microspheres - Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed.2014-02-06
20140039122PROCESS FOR PREPARING AQUEOUS VINYL POLYMER DISPERSIONS - The invention relates to a process for the preparation of aqueous vinyl polymer dispersions having good film forming properties, good stability and in can clarity, to the polymer dispersions obtainable by the process and coating compositions prepared from said polymer dispersions and the use thereof. The process comprising, (1) a first polymerisation step comprising (1a) preparing an emulsion (1A) in water of a first monomer mixture (1a1) comprising carboxylic acid functional monomers, a surfactant (1a2) and water soluble inorganic salt (1a3) wherein surfactant (1a2) is a sulfur based anionic surfactant containing less than 60 wt % ethylene oxide and wherein the salt (1a3) content at the start of polymerization (1b) is between 0.01 and 3 gr/kg water, (1b) emulsion polymerizing the obtained emulsion 1A forming a hydroplasticisable first stage polymer particle dispersion (1B) said first stage polymer having a Tg from 10 to 125°, (2) a second polymerization step comprising (2a) adding to dispersion 1B a second monomer mixture (2a1) wherein carboxylic acid functional monomers is present in an amount such that the acid value of the resulting polymer is less than 23 KOH/g and wherein the amount of monomer mixture (2a1) is between 10 and 90 wt % of the total weight of monomers (1a1) plus (2a1), (2b) polymerizing second monomer mixture (2a1) to form a second stage polymer in the first particle dispersion (1B) to form a multiphase particle dispersion (2B).2014-02-06
20140039123RESIN COMPOSITION, PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE LAYER, PRESSURE-SENSITIVE ADHESIVE SHEET, AND SURFACE PROTECTIVE FILM - A resin composition includes: a polyol (A) having two or more OH groups; a polyfunctional isocyanate compound (B); and a catalyst (C), in which: the content ratio of the polyfunctional isocyanate compound (B) with respect to 100 parts by weight of the polyol (A) is 1 part by weight to 100 parts by weight; and the catalyst (C) includes an iron complex compound. The resin composition can serve as a pressure-sensitive adhesive composition that is a material for forming a pressure-sensitive adhesive layer containing a polyurethane-based resin, the resin composition showing extremely high reactivity without any use of a tin compound as a catalyst, allowing a cross-linking reaction between a polyol and a polyfunctional isocyanate compound to rapidly progress, and being capable of providing a pressure-sensitive adhesive layer having high transparency. Also provided are a pressure-sensitive adhesive sheet and a surface protective film each including such pressure-sensitive adhesive layer.2014-02-06
20140039124SEALING MATERIAL OF POLYPROPYLENE WITH HIGH MELTING TEMPERATURE - Polypropylene composition comprising propylene homopolymer (H-PP) and a propylene copolymer (C-PP), said copolmyer comprises (a) a propylene copolymer fraction (A) having a comonomer content of equal or above 1.0 wt.-%, the comomers are C2014-02-06
20140039125POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM - A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a plurality of molecular modules. Molecular modules include targeting antibodies for promoting cellular uptake by a target cell, and pro-drugs for altering cellular metabolism, for example, a pro-drug that alters expression of protein kinase CK2.2014-02-06
20140039126Lanthanide Complex Catalyst And Polymerization Method Employing Same - A novel class of lanthanide metal salen complexes can be used as an ingredient of a catalyst system. The catalyst system can be used in polymerizations of ethylenically unsaturated hydrocarbon monomers.2014-02-06
20140039127POLYETHER ETHER KETONE COMPOSITE MATERIAL - A polyether ether ketone composite material of the present invention includes PEEK and polyolefin, in which the composite material has a single endothermic peak in a DSC. The PEEK and the polyolefin are preferably to have compatibility with each other, and the composite material may have a matrix part formed from the PEEK and a first dispersed part formed from the polyolefin having a particle size of 1 μm or smaller. The composite material may have a matrix part formed from the PEEK and a second dispersed part dispersed in the matrix part, and the second dispersed part may be formed from the PEEK and the polyolefin, a dispersion PEEK is dispersed in the polyolefin, and the second dispersed part has a particle size of 10 μm or smaller.2014-02-06
20140039128RADIATION-CURABLE PRESSURE-SENSITIVE ADHESIVE LAYER, AND RADIATION-CURABLE PRESSURE-SENSITIVE ADHESIVE SHEET - An object of the present invention is to provide a radiation-curable pressure-sensitive adhesive layer that satisfies both reworkability and adhesion reliance. Further, another object of the present invention is to provide a pressure-sensitive adhesive sheet containing the radiation-curable pressure-sensitive adhesive layer. The invention relates to a radiation-curable pressure-sensitive adhesive layer, which has an adhesive strength of 1.0 N/20 mm or less before radiation curing and an adhesive strength of 3.0 N/20 mm or more after radiation curing, and a peeling adhesive strength of 40.0 N/(20 mm×20 mm) or less before radiation curing, to an acrylic plate.2014-02-06
20140039129SOLVENT-FREE ENYNE METATHESIS POLYMERIZATION - The disclosure describes methods of metathesizing unsaturated organic compounds, each method comprising contacting at least one feedstock comprising at least one olefinic or acetylenic precursor with a solid transition metal-based metathesis catalyst in the absence of a liquid solvent or precursor to form a polymer product.2014-02-06
20140039130METHOD FOR PRODUCING FLUORINE-CONTAINING ELASTOMER - A peroxide-crosslinkable fluorine-containing elastomer IS produced by subjecting a fluorine-containing olefin and a perfluoroalkyl divinyl ether monomer represented by the general formula:2014-02-06
20140039131ELECTRONIC DEVICE AND POLYMER COMPOUND - An electronic device that serves as a high-brightness electroluminescent device includes a layer containing a polymer compound having one or more structural units selected from a structural unit represented by formula (1) and a structural unit represented by formula (14) as a charge injection layer and/or a charge transport layer:2014-02-06
20140039132C-SUBSTITUTED, 1H-AZOLES FOR AMPHOTERIC, SOLVENT-LESS PROTON CONDUCTIVITY - Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds.2014-02-06
20140039133CURABLE COMPOSITION AND METHODS FOR IMPROVING RECOVERY PROPERTIES AND CREEP PROPERTIES - Disclosed are a curable composition characterized by using a curable composition including an organic polymer (A1) having one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds in which the one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds are silicon-containing functional groups each having three or more hydrolyzable groups on one or more silicon atoms thereof; and a method for controlling the recovery properties, durability and creep resistance of the cured article. Herewith, the present invention provides a curable composition capable of giving a cured article excellent in recovery properties, durability and creep resistance, and a method for controlling the recovery properties, durability and creep resistance of the cured article.2014-02-06
20140039134POLYAMIDE COMPOSITION - Polyamide composition comprising a first polyamide, characterized in that the composition further comprises polyamide-PXD10 in an amount of at least 0.01 wt %, based on the total amount of polyamides in the composition. In a preferred embodiment of the invention, the first polyamide is an aliphatic polyamide chosen from the group of polyamide-6, polyamide-66 and polyamide-46. A fuel part, comprising the polyamide composition is also claimed.2014-02-06
20140039135CROSS-LINKED REACTIVE POLYMER MICROPARTICLES - Embodiments of the present disclosure include a composition of cross-linked reactive polymer microparticles and a method of producing cross-linked reactive polymer microparticles that includes reacting an epoxy resin with an amine curing agent in a dispersing media at a temperature of 50° C. to 120° C. for a reaction time of no greater than 17 hours so that the cross-linked reactive polymer microparticles have no greater than 0.001 weight percent of the dispersing media bound to the cross-linked reactive polymer microparticles; and phase separating the cross-linked reactive polymer microparticles and the dispersing media.2014-02-06
20140039136THERMOSET CROSS-LINKED NETWORK - Embodiments of the present disclosure include a thermoset cross-linked network and a method of producing the thermoset cross-linked network from a reaction product of a curable epoxy system in a liquid phase and cross-linked reactive polymer microparticles in a solid phase. For the various embodiments, the cross-linked reactive polymer microparticles have a cross-link density and reactive groups that covalently react with the curable epoxy system to provide the thermoset cross-linked network in a single contiguous phase having a topological heterogeneity.2014-02-06
20140039137Polyalphaolefins Prepared Using Modified Salan Catalyst Compounds - Disclosed herein are polyalphaolefins and Salan cataylsts, catalyst systems, and processes to produce the polyalphaolefins.2014-02-06
20140039138Catalysts Comprising Salan Ligands - Catalysts comprising salan ligands with carbazole moieties. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.2014-02-06
20140039139Nonsymmetric Catalysts Comprising Salan Ligands - Catalysts comprising a non-symmetrical Salan ligand with a carbazole moiety. Also disclosed are catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.2014-02-06
20140039140Vinyl Terminated Polyethylene with Long Chain Branching - Vinyl terminated polyolefins with long chain branching produced with Salan catalysts having carbazole moieties.2014-02-06
20140039141Halogenated Catalysts Comprising Salan Ligands - Catalysts comprising a halogenated Salan ligand. Also disclosed are catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.2014-02-06
20140039142EXTRUDER WITH INTEGRATED DIE PLATE AND METHOD FOR DEGASING POLYMER MIXTURES - The invention is directed to an extruder (2014-02-06
20140039143PROCESS FOR PRODUCING PROPYLENE FROM SYNGAS VIA FERMENTATIVE PROPANOL PRODUCTION AND DEHYDRATION - A process for making propylene by dehydration of propanol can include gasifying a carbonaceous solid or liquid feedstock, or reforming a gaseous carbonaceous feedstock into synthesis gas. The synthesis gas can be fermented or co-fermented by means of a microorganism into propanol. The microorganism can be a wild strain having the natural capability to ferment synthesis gas into propanol. The microorganism can be a microorganism possessing the required nucleic acid sequence information to express the enzymes for the biosynthesis of C2014-02-06
20140039144Compositions Comprising Lignin - Compositions comprising lignin and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.2014-02-06
20140039145METHOD OF PRODUCING RESIN FOR THIOURETHANE-BASED OPTICAL MATERIAL USING GENERAL-PURPOSE POLYISOCYANATE COMPOUND, RESIN COMPOSITION FOR THIOURETHANE-BASED OPTICAL MATERIAL AND THIOURETHANE-BASED OPTICAL MATERIAL INCLUDING RESIN PRODUCED BY THE METHOD - Disclosed is a method of producing a high-quality thiourethane-based optical material using a general-purpose polyisocyanate compound. According to the method, the pH of a polythiol compound is adjusted to 3.1 to 7 to prevent the occurrence of whitening, which is a problem of the prior art arising from the dissolution of a pressure-sensitive adhesive from a pressure-sensitive adhesive tape upon lens casting. The pH adjustment increases the reaction rate of a resin composition including the polythiol compound. The use of the polythiol compound whose pH is adjusted enables the production of a thiourethane-based optical material that does not suffer from whitening at the edges of the optical lens and nonuniformity polymerization. Further disclosed are a resin composition for a thiourethane-based optical material, and an optical material including a resin produced by the method.2014-02-06
20140039146WATER BASED LIGNIN EPOXY RESINS, METHODS OF USING AND MAKING THE SAME - Water based lignoepoxy resins, and methods for their preparation and use are provided. Methods of making lignoepoxy resins without the use of volatile organic compounds are also provided.2014-02-06
20140039147TAGGED POLYMERS AND METHODS OF USE - A polymer includes a monomeric repeat unit represented by Formula I:2014-02-06
20140039148POLYMER - A polymer, for use in an organic light emitting device, comprises asymmetrically substituted repeat units of formula (I (a)): wherein R7 represents a substituent bound to the 9-carbon atom of the fluorene ring through a non-aromatic carbon atom, R2014-02-06
20140039149COPOLYMER POLYESTER RESIN AND MOLDED PRODUCT USING SAME - The present invention relates to a copolymer polyester resin and a molded product using the same, and more specifically to a copolymer polyester resin that contains 10˜80 mol % of 1,4-cyclohexane dimethanol, 0.1˜50 mol % of a diol compound expressed as HO—(CH2014-02-06
20140039150PHOTOPOLYMERIZABLE COMPOSITIONS FOR SOLVENTLESS FIBER SPINNING - Disclosed are methods of fiber spinning and polymer fibers that utilize multifunctional thiol and enes compounds. Also, the subject matter disclosed herein relates to uses of polymer fibers and articles prepared from such fibers.2014-02-06
20140039151SYNTHESIS OF AND CURING ADDITIVES FOR PHTHALONITRILES - A method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; an excess of a dihydroxyaromatic compound; an organic transition metal complex or a transition metal salt; a base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form an aromatic ether oligomer that is a dihydroxy-terminated compound or a dimetallic salt thereof. Water formed during the heating is concurrently distilled from the solution. A method of curing a phthalonitrile monomer in the presence of an acid and a curing agent to form a phthalonitrile thermoset.2014-02-06
20140039152POLY(ETHYLENEOXIDE) FUNCTIONALIZATION THROUGH ALKYLATION - A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.2014-02-06
20140039153CANCER IMAGING AND TREATMENT - A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure:2014-02-06
20140039154PROTEIN DISULFIDE ISOMERASE ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - A method for the in vitro diagnosis of colorectal cancer that comprises determining the presence of the protein disulfide isomerase tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-PDI monoclonal antibody directed against a PDI epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, with an aromatic amino acid which is close in the three-dimensional structure of PDI and SEQ ID No.3.2014-02-06
20140039155AMYLOID-BETA PEPTIDE CRYSTAL STRUCTURE - The invention relates provides a novel crystal structure of the fibrillogenic part of amyloid β-peptide (Aβ). More specifically the crystal structure is Aβ-IgNAR and, accordingly the present invention also relates to selecting and/or designing compounds that modulate amyloid β-peptide (Aβ) activity using techniques such as in silico screening and crystal soaking experiments. The invention further relates to compounds and methods for inhibiting interaction between amyloid β-peptide (Aβ) monomers, more particularly, inhibiting or disrupting amyloid β-peptide (Aβ) oligomer formation and toxic activity.2014-02-06
20140039156HIGH-THROUGHPUT SCREENING FOR COMPOUNDS MODULATING EXPRESSION OF CELLULAR MACRO-MOLECULES - A method of screening for compounds that module expression of specific macromolecules, the “target”. The method is particularly useful in that it does not require separation of target-bound and excess ligand and therefore enables, but is not limited to, High Throughput Screening for compounds that increase or decrease the levels or amounts of a target present in a biological sample. The method can also be used for high-throughput diagnosis of a condition leading to an increase or decrease of a cellular macromolecule.2014-02-06
20140039157METHODS AND COMPOSITION FOR MEASURING THE AMOUNT OF VITAMIN D DERIVATIVES - Methods and compositions for measuring the amount of vitamin D derivatives are disclosed. Fluorescence Resonance Energy Transfer (FRET) in combination with a modified ligand-binding domain of the vitamin D receptor (LBD-VDR) to measure vitamin D derivatives are also disclosed.2014-02-06
20140039158POLYMERIC CONJUGATES AND METHODS OF PREPARING THE SAME - Methods of preparing polymer target conjugates which are substantially free of polymer attachment on the N-terminal of the targets are provided. Also provided are compositions comprising a plurality of polymer-polypeptide conjugates, said polymer-polypeptide conjugate comprising a polypeptide covalently attached to at least one polymer through an epsilon amino group of a Lysine or a Histidine found on the polypeptide and said conjugates containing less than 5% of the polymer-polypeptide conjugates having a polymer attached to the N-terminal of the polypeptide; and polymer target conjugates comprising a target moiety selected from the group consisting of polypeptides, proteins and the like having at least one polymer attached thereto at a site which is not the N-terminal of the target.2014-02-06
20140039159ELECTROACTIVE BIOPOLYMER OPTICAL AND ELECTRO-OPTICAL DEVICES AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.2014-02-06
20140039160NOVEL PROCESS FOR THE PREPARATION OF A VIRUS-INACTIVATED FV CONCENTRATE STARTING FROM HUMAN PLASMA, SCALABLE TO INDUSTRIAL LEVEL - The present invention provides a process for purifying FV starting from human plasma or a fractionation intermediate thereof, that is simple, scalable to the industrial level and relatively inexpensive compared to the methods described in the literature to date. The invention consists of the use of two anion exchange chromatography steps, the first of which has the purpose of separating the FV from the PTC component factors, while the second has the purpose of isolating the protein of interest from the majority of plasma proteins by means of selective interaction with the weak anion exchange support used. The process developed has also had a viral inactivation step and a viral removal step included, contributing to the safety of the final product obtained, without however significantly altering the process total recovery of FV, and without necessitating the introduction of additional steps for eliminating the inactivating agents used, thanks to the order in which the various steps are conducted. The process described in the present invention also enables an FV concentrate to be obtained that is stable once frozen at −20° C.2014-02-06
20140039161METHOD FOR EXTRACTING IgY (r-LIVETIN) FROM EGG YOLK - A method for extracting IgY (γ-livetin) from yolk is disclosed, which comprises the following steps: (A) providing a buffer solution, a yolk sample, and an inorganic salt solution; (B) diluting the yolk sample with the buffer solution to obtain a mixture, stirring the mixture for a predetermined time, and performing a centrifugation on the mixture to obtain a supernatant; and (C) adding the inorganic salt solution into the supernatant to salt out IgY, wherein a pH value of the buffer solution is in a range from 4.6 to 5.4, a salt concentration of the buffer solution is in a range from 0.05 M to 0.15 M, and a saturation degree of the inorganic salt solution is in a range from 30% to 60%.2014-02-06
20140039162Displaying native human IgE neutralizing FceRla-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold - Vaccine displaying native antigenic loops of immunoglobulin E is critical for eliciting neutralizing anti-IgE antibodies. The embodiment of the invention enables the display of native antigenic IgE receptor-contacting loops as IgE B-cell vaccines via three steps of constraining methods. The loops of multiple antigenic B-cell epitopes can be molecularly grafted in, and conformationally constrained by the energy favorable flanking beta (b)-stands, i.e., the super b-strands identified in this invention. The constrained loops can be further stabilized in replacing a selective loop within the cystine knot peptide. These dual constrained antigenic loops are then integrated onto thermostable protein scaffolds, folded in the oxidative milieu that provides further conformational constraint and high yield.2014-02-06
20140039163CHOLESTEROL-DEPENDENT CYTOLYSIN VARIANT AND USE THEREOF IN DDS - The present invention provides a carrier capable of delivering a medical agent capsule encapsulating a medical agent to various target cells and tissues to cause the medical agent to be taken therein in an efficient and highly safe manner, and a drug delivery system using the carrier. The carrier has a cell or tissue specific antibody bound to an antibody binding domain of a cholesterol-dependent cytolysin variant of the present invention. The carrier can also have bound thereto, as a transport material, a functional cell or a cholesterol-containing microcapsule filled with a medicinal ingredient or a bioactive substance via domain 4 of the variant.2014-02-06
20140039164THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY - Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.2014-02-06
20140039165ANTI-NR10 ANTIBODY AND USE THEREOF - The present inventors successfully obtained anti-NR2014-02-06
20140039166SILICA NANOPARTICLE FOR DIAGNOSTIC IMAGING, METHOD FOR PRODUCING THE SAME, AND BIOSUBSTANCE LABELING AGENT - A silica nanoparticle for diagnostic imaging that may be capable of use for X-ray CT, fluorescent imaging, or the like, and have high emission intensity. A method for producing such a silica nanoparticle for diagnostic imaging is provided. Also, a biosubstance labeling agent using the silica nanoparticle for diagnostic imaging is provided. The silica nanoparticle for diagnostic imaging encapsulates an organic fluorescent dye and a metal complex, wherein a ligand of the metal complex form a covalent bond with constituent molecules of the silica nanoparticle.2014-02-06
20140039167Polymer Derivatives Comprising an Acetal or Ketal Branching Point - The invention conjugates that can be prepared by contacting a polymer comprising an acetal or ketal branching point with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent.2014-02-06
20140039168Lignosulfonate Compounds For Solid Ink Applications - A lignosulfonate compound for phase change ink of the formula2014-02-06
20140039169LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES - The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.2014-02-06
20140039170COMPOSITION FOR TOPICAL SKIN APPLICATION CONTAINING GINSENOSIDE F2 DERIVED FROM HYDROPONIC GINSENG - Beneficial effects are obtained by topically applying ginsenoside F2 to the skin to improve skin conditions, improve water content on the skin surface and related benefits improving skin problems associated with acne or atopy, providing a skin whitening effect, helping control of sebaceous secretion, tightening skin pores, or improving skin complexion through enhanced blood circulation, but also to improve scalp and hair conditions, such as providing an anti-dandruff effect, promoting hair growth, or preventing generation of grey hair.2014-02-06
20140039171NOVEL MACROLIDE INTERMEDIATE AND NOVEL PRODUCTION PROCESS - Provided are: a novel monoalkylamino intermediate (I); and a production method for a compound represented by the formula (III), which is an animal antibacterial agent, via the novel monoalkylamino intermediate.2014-02-06
20140039172DEVICES AND SYSTEMS FOR ISOLATING BIOMOLECULES AND ASSOCIATED METHODS THEREOF - A device, a system, and a method for isolating biomolecules from biological materials are provided. The device comprises a quartz-based solid phase extraction matrix comprising one or more reagents impregnated therein; and an electroosmotic pump (EOP) operationally coupled to the quartz-based solid phase extraction matrix to elute the nucleic acids, wherein the EOP comprises a plurality of electroosmotic membranes comprising one or more positive electroosmotic membranes and one or more negative electroosmotic membranes disposed alternatively and a plurality of electrodes comprising one or more cathodes and one or more anodes, wherein at least one cathode is disposed on one side of one of the membranes and at least one anode is disposed on another side of that membrane and at least one cathode or anode is disposed between a positive electroosmotic membrane and a negative electroosmotic membrane.2014-02-06
20140039173GENERATION AND REPRODUCTION OF DNA SEQUENCES AND ANALYSIS OF POLYMORPHISMS AND MUTATIONS BY USING ERROR-CORRECTING CODES - The present invention relates to a method that uses error-coding codes for validating polymorphisms and mutations/alterations in a DNA sequence which encodes a polypeptide sequence. The present invention also relates to a digital communication system for carrying out the method, employing a model for the biological coding system which resembles the most efficient digital communication. The method and digital communication system may be useful for the predictive analysis of diseases originated by mutations or polymorphisms in genes.2014-02-06
20140039174RIBONUCLEIC ACID BINDING MOTIF PROTEIN 20 SEQUENCE VARIANTS - This document relates to methods and materials for using nucleic acid and amino acid sequence variants of ribonucleic acid binding motif protein 20 (RBM20). For example, methods and materials for using nucleic acid sequence variants and/or their corresponding amino acid variants of RBM20 that are associated with dilated cardiomyopathy to identify mammals (e.g., humans) at risk of having dilated cardiomyopathy that is likely to progress to heart failure are provided.2014-02-06
20140039175Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides - The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.2014-02-06
20140039176METHODS AND KITS FOR EXTRACTION OF DNA - Methods and materials are disclosed for use in recovering a biopolymer from a solution. In particular, the invention provides methods for extraction and isolation of nucleic acids from biological materials. The nucleic acids can be separated by forming a stable complex with soluble polysaccharide polymers and magnetic particles, in the presence of detergents and solvent. When the particles are magnetically separated out of the solution, the nucleic acids are separated with them. The nucleic acids can subsequently be released and separated from the particles. The nucleic acid preparation is useful for achieving efficient and accurate results in downstream molecular techniques such as quantification, identification of the source of the nucleic acids, and genotyping.2014-02-06
20140039177METHODS OF ISOLATING NUCLEIC ACIDS UNDER REDUCED DEGRADATION CONDITION - A method of isolating nucleic acids from a biological material, comprises applying the biological material on a substrate comprising one or more cell lysis reagents impregnated therein; applying a fluid to the biological material applied on the substrate; extracting the nucleic acids from the biological material applied on the substrate; and collecting the extracted nucleic acids in a substantially intact form, wherein the collected nucleic acid has a molecular weight greater than or equal to 20 kb.2014-02-06
20140039178Synthesis of deuterated ribo nucleosides N-protected phosphoramidites, and oligonucleotides - The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.2014-02-06
20140039179PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION - The invention is directed to processes of preparing phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. These compounds can be described by general formula (II)2014-02-06
20140039180MANNOSE PRODUCTION FROM PALM KERNEL MEAL USING SIMULATED MOVING BED SEPARATION - Disclosed is a process for the production of d-mannose from fermented palm oil kernel meal using a continuous SMB separation process. The process is useful for providing a simplified processing route to providing high purity d-mannose. The SMB process and the SMB cycle was operated to provide a high purity mannose stream comprising d-mannose, salts, and color agents, a primary raffinate comprising glucose, other sugars and salts, and a secondary raffinate consisting essentially of the mobile phase desorbent. In the SMB cycle, the secondary raffinate was recycled to the SMB process as the mobile phase desorbent without further desalination. The highly pure mannose stream was further treated to remove color agents and salts prior to subsequent steps of precipitation or crystallization and drying. D-mannose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.2014-02-06
20140039181METHOD FOR PRODUCING N-SUBSTITUTED AMINE COMPOUNDS THROUGH CATALYZED ALKYLATION - The invention relates to a method for producing a N-substituted amine compound by catalyzed alkylation. The method uses amine and alcohol or two kinds of amines as the reaction materials, employs composite metal oxides catalyst at a reaction temperature of 80-180° C. to catalyze the reaction for 6-36 hours, so as to produce the N-substituted amine compound. The reaction condition of the method of the invention is relatively moderate, using a catalyst made of cheap non-noble metals, which is non-caustic and easy to be separated and reused. The reaction does not need any medium and has relatively high conversion rate and selectivity.2014-02-06
20140039182COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME - The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.2014-02-06
20140039183SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS - Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.2014-02-06
20140039184PHENALENE-1-ONE DERIVATIVES, METHOD FOR PRODUCING SAME AND USE THEREOF - The present disclosure relates to a compound of formula (1):2014-02-06
20140039185SYNTHESIS OF TWO-PHOTON ABSORBING POLYHYDROXY DIPHENYLAMINO-DIALKYLFLUORENE-1,3,5-TRIAZINE MOLECULES - A method of synthesizing a two-photon active tris(diarylamino-9,9-di(R)fluorenyl)-1,3,5-triazine compound having the structure:2014-02-06
20140039186INHIBITORS OF BRUTON'S TYROSINE KINASE - Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.2014-02-06
20140039187CXCR4 ANTAGONISTS FOR THE TREATMENT OF MEDICAL DISORDERS - The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.2014-02-06
20140039188NOVEL ISO-ERGOLINE DERIVATIVES - Provided herein are novel iso-ergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT2014-02-06
20140039189NOVEL PROCESS FOR THE PREPARATION OF ACYLGUANIDINES AND ACYLTHIOUREAS - The present invention relates to a novel process for the preparation of compounds of general formula (I)2014-02-06
20140039190BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - Compounds of general formula A useful as potential anticancer agents against human cancer cell lines and a process for the preparation thereof.2014-02-06
20140039191Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X2014-02-06
20140039192METAL COMPLEXES WITH BORON-NITROGEN HETEROCYCLE CONTAINING LIGANDS - Novel organic compounds comprising a boron-nitrogen heterocycle are provided. In particular, the compound contains an azaborine. The compounds may be used in organic light emitting devices to provide devices having improved photophysical and electronic properties.2014-02-06
20140039193BORON CONTAINING PERYLENE MONOIMIDES, A PROCESS FOR THEIR PRODUCTION, THEIR USE AS BUILDING BLOCKS FOR THE PRODUCTION OF PERYLENE MONOIMIDE DERIVATIVES, MONOIMIDE DERIVATIVES AND THEIR USE IN DYE-SENSITIZED SOLAR CELLS - Boron-comprising perylene monoimides and a process for producing the boron-comprising perylene monoimides are provided. The boron-comprising perylene monoimides are useful as building blocks for producing perylene monoimide derivatives and monoimide derivatives. The boron-comprising perylene monoimides are also useful for preparing dye-sensitized solar cells.2014-02-06
20140039194PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS - The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.2014-02-06
20140039195Squarylated Lactones Inhibitors for Bacterial Biofilm Formation - A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 μM), these small molecules inhibit biofilm formation of 2014-02-06
20140039196PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling.2014-02-06
20140039197PROCESSES FOR THE PREPARATION OF 3,5-DISUBSTITUTED-1,2,4-OXADIAZOLES - Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.2014-02-06
20140039198PYRROLE DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF - An object of the present invention is to provide a pyrrole derivative useful as an immunosuppressive agent and a method for producing the same. For achieving the object, the present invention provides a method for producing a compound represented by the general formula (I) by heating a compound represented by the general formula (III) and a compound represented by the general formula (IV) in a nonpolar solvent under reduced pressure.2014-02-06
20140039199PROCESS FOR THE PREPARATION OF DEFERASIROX - The present invention provides improved process for the preparation of Deferasirox of formula (I).2014-02-06
20140039200ORGANOGOLD COMPLEXES AND METHODS FOR MAKING THE SAME - The present invention relates to chiral ligands deriving from α- and β-amino acids, and from metal complexes formed from the same. The ligands are useful with catalytic gold complexes, particularly Au(I) complexes.2014-02-06
20140039201COLOR MATERIAL AND METHOD FOR PRODUCING THE SAME - Color materials represented by the following general formula (I):2014-02-06
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