| 05th week of 2016 patent applcation highlights part 40 |
| Patent application number | Title | Published |
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| 20160033454 | ULTRASONIC DEVICE, METHOD FOR MANUFACTURING THE SAME, PROBE, AND ELECTRONIC APPARATUS - An ultrasonic device that has high accuracy with respect to frequency and sensitivity and that can achieve a reduction of crosstalk is provided. A substrate of an ultrasonic device has a first surface and a second surface on a side opposite to the first surface, and has a first opening and a second opening that are separated from each other by a wall portion. A first vibration film and a second vibration film that close the first opening and the second opening, respectively, are disposed on the first surface of the substrate. A first piezoelectric element and a second piezoelectric element are provided on the first vibration film and the second vibration film, respectively. A recess that opens in the second surface of the substrate is demarcated in the wall portion. | 2016-02-04 |
| 20160033455 | TRI-MODE PROBE WITH AUTOMATIC SKEW ADJUSTMENT - A probe, including a first input configured to receive a first input signal, a second input configured to receive a second input signal, a first cable connected to the first input, a second cable connected to the second input, an electronically adjustable delay connected to the first cable, the electronically adjustable delay configured to delay the first input signal to remove a skew between the first input signal and the second input signal, and an amplifier configured to receive the first input signal from the electronically adjustable delay and a second input signal. | 2016-02-04 |
| 20160033456 | Gaseous Mercury Detection Systems, Calibration Systems, and Related Methods - Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air. For example, the gaseous mercury detection systems collect gas-phase mercury-compounds from ambient air and release the gas-phase mercury-compounds at concentrations capable of being measured by a gas-chromatography mass spectrometer without heating the gas-phase mercury-compounds above a decomposition temperature of at least one gaseous mercury compound that may present in the mercury-containing gas. The calibration systems are configured to determine an accuracy of or calibrate a gaseous mercury detection system. The disclosed calibration systems may be integrated with or distinct from the gaseous mercury detection systems disclosed herein. | 2016-02-04 |
| 20160033457 | CHROMATOGRAM DATA PROCESSING DEVICE AND PROCESSING METHOD - Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impurities can be performed with high accuracy without the requirement of complicated computation processing. | 2016-02-04 |
| 20160033458 | MASS ANALYSIS DATA PROCESSING APPARATUS AND MASS ANALYSIS DATA PROCESSING METHOD - To enhance the efficiency in the operation of checking a plurality of mass spectra acquired by measuring MS | 2016-02-04 |
| 20160033459 | QUANTITATION OF AMINES IN HYDROCARBONS - The present disclosure relates to methods for quantitation of amines in hydrocarbon stream. More specifically, the disclosure relates to rapid, precise and highly-sensitive methods for quantitating hydrogen sulfide-scavenging amines in crude petroleum oil or refinery streams. | 2016-02-04 |
| 20160033460 | System and Method for Automatically Adjusting Gas Sensor Settings and Parameters - An automatic sensor excitation voltage adjustment feature, a multi-range concentration feature, a single calibration feature and a barrier circuit feature. The automatic sensor excitation voltage adjustment feature includes a transmitter having a transmitter microprocessor that provides an initial voltage to a sensor having a sensor microprocessor. As the voltage changes a correction signal is relayed from the sensor microprocessor to the transmitter microprocessor. The correction signal is used to adjust the voltage applied to the sensor. The multi-range concentration sensor feature includes an amplifier associated with the sensor/microprocessor to create gain settings used to optimize sensor resolution by changing a gain value for the sensor. This enables use of a single sensor for a variety of different concentration ranges. The single calibration feature enables a sensor to be calibrated at a single gas concentration value, and thereafter be used for a variety of different concentration range applications. The barrier circuit feature provides for intrinsically safe power and communication signals to the sensor. | 2016-02-04 |
| 20160033461 | MULTI-FUNCTIONAL PIEZO ACTUATED FLOW CONTROLLER - Multi-functional piezo-actuated flow control systems and methods for use in gas exchange analysis systems such as photosynthesis measurement systems. A fluid valve assembly module includes a housing structure including a plurality of ports and a plurality of fluid passageways interconnecting the ports, and a plurality of piezo-actuated valves in fluid communication with the fluid passageways, each valve including a piezo element that controls flow along a passageway, wherein the passageways and valves are arranged within the housing structure so as to define a fluid control module, which includes a flow swapping component, a flow splitting component and a flow pressurization component. The flow swapping component has first and second inlets and first and second output ports and is configured to receive a first fluid flow at the first inlet and a second fluid flow at the second inlet and in a first operational mode to direct the first fluid flow to the first output port and the second fluid flow to the second output port, and in a second operational mode to direct the first fluid flow to the second output port and the second fluid flow to the first output port. The flow splitting component has an input port, a third output port and a first outlet and is configured to receive an input fluid flow at the input port and to control an amount of the input fluid flow provided to the third output port and to the first outlet in a continuously adjustable manner, wherein the first outlet is fluidly connected to the first inlet of the flow swapping component and the third output port is adapted to be fluidly coupled with an external reservoir. The flow pressurization component has an entry port in fluid communication with a second outlet and is configured to receive a third fluid flow at the entry port and to control the pressure of the third fluid flow at the second outlet, wherein the second outlet is fluidly connected to the second inlet of the flow swapping component and the entry port is adapted to be fluidly coupled with the external reservoir. | 2016-02-04 |
| 20160033462 | WELLHEAD WATER QUALITY DETECTOR - A module gathers information about water quality indicators in the air above water in a water well and in the ambient air outside the water well. The module sends the information to a database. A detector tracks the substances present inside and outside the well and how it changes over time. | 2016-02-04 |
| 20160033463 | METHOD AND APPARATUS FOR A COOKING OIL QUALITY SENSOR - A fryer includes a fryer pot, a filter pan connected to the fryer pot by a drain conduit and a return conduit forming a filtration loop, a cooking oil quality sensor being in the filtration loop, and a controller that controls operation of a filtration cycle of the fryer. The filtration cycle has a circulation sequence and a fill sequence. The circulation sequence circulates cooking oil through the filtration loop and the fill sequence fills the fryer pot with the cooking oil from the filter pan. The controller stops the fill sequence after filling the fryer pot with a predetermined amount of cooking oil during a partial fill and resumes the fill sequence after a predetermined amount time elapses to complete the fill sequence. The cooking oil quality sensor measures a cooking oil quality to obtain a cooking oil quality measurement during the predetermined amount time. | 2016-02-04 |
| 20160033464 | METHODS FOR DETERMINING ACTIVE INGREDIENTS OF AN HERBAL MEDICINE, SOURCES OF AND CATALYTIC PATHWAYS FOR PRODUCTION THEREOF - Disclosed are methods for determining active ingredients of herbal medicines including identifying organic sources and catalytic (mineral) pathways to produce such active ingredients. | 2016-02-04 |
| 20160033465 | MOBILE-BASED COLLECTION OF WATER QUALITY MEASUREMENT DATA - Methods and arrangements for collecting data related to a water quality sample location. Identifying information of a water quality sample container is electronically obtained, and identifying information of a water quality sample location is electronically obtained. There is placed, in the container, a water sample from the water quality sample location. There is stored the identifying information of the water quality sample container and the identifying information of the water quality sample location; such storing includes associating the identifying information of the water quality sample container and the identifying information of the water quality sample location. Other variants and embodiments are broadly contemplated herein, including methods and arrangements for validating water quality sample data. | 2016-02-04 |
| 20160033466 | APPARATUS AND METHOD FOR THE CHARACTERIZATION OF RESPIRABLE AEROSOLS - An apparatus for the characterization of respirable aerosols, including: a burn chamber configured to selectively contain a sample that is selectively heated to generate an aerosol; a heating assembly disposed within the burn chamber adjacent to the sample; and a sampling segment coupled to the burn chamber and configured to collect the aerosol such that it may be analyzed. The apparatus also includes an optional sight window disposed in a wall of the burn chamber such that the sample may be viewed during heating. Optionally, the sample includes one of a Lanthanide, an Actinide, and a Transition metal. | 2016-02-04 |
| 20160033467 | FUEL WATER SEPARATOR BOWL WITH AN INTERNAL INSPECTION LIGHT - An internal inspection light system for a fuel water separator bowl of a fuel filtration system is disclosed. The internal inspection light system includes an assembly body, a compartment, and a light source. The assembly body is configured to attach to the fuel water separator bowl. The compartment includes a compartment wall extending from the assembly body with at least a portion of the compartment wall being formed of a material such that sufficient light can pass through the compartment wall to illuminate the fuel water separator bowl, and a compartment cap connected to the compartment wall distal to the assembly body. The light source is located within the compartment. | 2016-02-04 |
| 20160033468 | MULTI-COMPONENT FLUID DETERMINATION IN A WELL BORE - A fluid measurement system and method for determining component mixtures flowing in a conduit such as an oil well. The system includes a sensor wire for location in a well bore; a signal generator for injecting a high frequency signal along the wire; a data acquisition unit to record first reflected signals received from the wire; a system criteria unit to maintain a data set relevant to the system, and a processor unit operable to act upon the first reflected signals and the data set to establish an output indicative of component fluid within the well bore from which the mixture of fluids flowing within the well bore can be determined. An iterative process can be used with waveguide and probabilistic models. | 2016-02-04 |
| 20160033469 | SENSOR, PHASE SEPARATION DETECTING SYSTEM AND PHASE SEPARATION DETECTING METHOD - A sensor includes a detection portion and an output portion. The detection portion is made of a material that changes in accordance with a ratio of an actual amount of water to an amount of water causing a phase separation in an alcohol containing fuel. The output portion is configured or programmed to output a signal in accordance with a change of the detection portion. | 2016-02-04 |
| 20160033470 | Methods And Instrumentation For During-Synthesis Monitoring Of Polymer Functional Evolution - A method of monitoring the evolution of polymer and/or colloid stimuli responsiveness during synthesis of polymers and/or colloids, including postpolymerization modifications on natural and synthetic polymers, includes providing a reactor in which the polymers and/or colloids are synthesized; and providing a means of monitoring the stimuli responsiveness of the polymers and/or colloids during said synthesis. Preferably, the method also includes monitoring the evolution of the characteristics of the polymers and/or colloids during said synthesis. Preferably, evolution of polymer and/or colloid stimuli responsiveness is correlated to the evolution of the properties of the polymers and/or colloids themselves. Also, preferably the conditions of the fluid in the reactor in which the synthesis occurs is determined. The determination can be by detection, choice of materials and temperature conditions, for example, and combinations thereof. The method and instrumentation disclosed can lead to optimization and control of processes and synthetic and modification strategies leading to polymers and colloids with desired stimuli responsiveness. | 2016-02-04 |
| 20160033471 | Optoelectronic Control Of Solid-State Nanopores - Optoelectronic control of solid-state nanopores and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. Methods for controlling the translocation speed of biopolymers through solid-state nanopores and methods for unblocking clogged pores by illuminating nanopores are described. | 2016-02-04 |
| 20160033472 | TRIMETHYLAMINE AS A BIOMARKER OF PREBIOTIC EFFICACY FOR WEIGHT GAIN PREVENTION - The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to trimethylamine as a biomarker in urine of the efficacy of prebiotics for the prevention of diet induced weight gain. | 2016-02-04 |
| 20160033473 | INDOXYL SULFATE AS A BIOMARKER OF PREBIOTIC EFFICACY FOR WEIGHT GAIN PREVENTION - The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to indoxyl sulfate as a biomarker in urine of the efficacy of prebiotics for the prevention of diet induced weight gain. | 2016-02-04 |
| 20160033474 | ALPHA-KETO-ISOVALERATE AS A BIOMARKER OF PREBIOTIC EFFICACY FOR WEIGHT GAIN PREVENTION - The present invention relates generally to the field of nutrition and health, particular, the present invention relates to alpha-keto-isovalerate as a biomarker urine of the efficacy of prebiotics for the prevention of diet induced weight gain. | 2016-02-04 |
| 20160033475 | PLATELET AGGREGATION TEST AND DEVICE - An assembly for testing platelet aggregation including an electrode subassembly that is mounted in a cuvette subassembly for use with relatively small samples containing platelets. | 2016-02-04 |
| 20160033476 | SYSTEM AND METHOD FOR UTILIZING EXHALED BREATH FOR MONITORING INFLAMMATORY STATES - A system for monitoring an exhaled breath of a subject is described. A breath collector can be configured to receive exhaled breath from a subject. One or more sensors can be configured to output a concentration of a first gas compound in the received exhaled breath, and to output a concentration of a second gas compound in the received exhaled breath. The second gas compound is used to normalize the concentration of the first gas based on different physiological states of the subject. A processor operably coupled to the one or more sensors is configured to calculate a ratio of the first gas compound to the second gas compound based on the determined concentrations, and to determine a normalized concentration of the first gas compound. This ratio may be monitored to evaluate an inflammatory state of the subject. | 2016-02-04 |
| 20160033477 | REPLACEABLE ALCOHOL SENSOR MODULE - A replaceable alcohol sensor module for use with a breathalyzer. The alcohol sensor module requiring calibration can be removed from the body of the breathalyzer and replaced with a new alcohol sensor module. The replaceable alcohol sensor module has at least an alcohol sensor and an adapter that removably connects the replaceable sensor module to the breathalyzer. The adapter transmits the electrical current generated by the alcohol sensor to a processor of the breathalyzer for processing. The alcohol sensor and the adapter are mounted on a printed circuit board to provide the replaceable sensor module. | 2016-02-04 |
| 20160033478 | HEMOKININ-1 RECEPTOR AND HEMOKININ-1-DERIVED PEPTIDE - The present invention provides a peptide having antagonist activity against SP, pain control activity, anti-inflammation activity, and anti-pruritic activity. The present invention further provides a method for searching for a therapeutic agent for pain, a therapeutic agent for inflammation, and a therapeutic agent for pruritus using G protein coupled receptor (GPR) 83, which is an HK-1 specific receptor. | 2016-02-04 |
| 20160033479 | SYSTEMS AND METHODS FOR DETECTION OF CELLULAR STRESS - There are provided methods for detection and measurement of stress in a cell, the method including introducing a labeled tRNA into the cell and detecting a change in subcellular localization of the labeled tRNA in the cell, based on the signal emitted from the labeled tRNA. There are further provided methods and systems for the generation of a stress index of a living cell. There are further provided methods and systems for detection of stress in a living cell, comprising detection of changes in subcellular localization of labeled tRNA in a cell, wherein the detection is performed in real time. | 2016-02-04 |
| 20160033480 | Immunovir and Components, Immunovir A, B, C, D Utility and Useful Processes - A complete remedy for AIDS is difficult to obtain. As such, a useful process was designed to search for an anti-HIV | 2016-02-04 |
| 20160033481 | RE-TRAFFICKING OF HERG REVERSES LONG QT SYNDROME 2 PHENOTYPE IN HUMAN IPS-DERIVED CARDIOMYOCYTES - The present invention relates to generating hiPSC-derived cardiomyocytes and embryoid bodies that recapitulate the disease phenotype of Long QT Syndrome and their use in developing pharmacological treatments thereof. The present invention also includes the use of a compound which inhibits the ubiquitin-proteasome pathway for the preparation of a medicament for the prophylaxis or treatment of a disease associated with prolonged ventricular repolarization (cardiac arrhythmia) caused by one or more mutations in the amino acid sequence of the hERG potassium channel. | 2016-02-04 |
| 20160033482 | BIOLOGICAL SPECIMEN EVALUATION METHODS USING CYTOLOGY AND IMMUNOLOGY - Information on cytokines and cytology obtained from a biological specimen are combined as a method of predicting the risk that dysplasia will progress to cancer. Methods are disclosed herein to augment the evaluation of biological samples from subjects being tested for cancer. In addition to the cell types that are traditionally considered in the morphology-based cytological screening of specimens, methods disclosed herein add evaluations of certain cell types and cytokines that are traditionally discounted or ignored during screening. | 2016-02-04 |
| 20160033484 | SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS - The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester. | 2016-02-04 |
| 20160033485 | COMPOSITIONS AND METHODS FOR CANCER DIAGNOSIS - The present disclosure provides compositions comprising a food product, non-pathogenic microorganism, kits, methods of diagnosing a tumor in a subject, methods of quantifying the number of cancer cells in a cell sample, and methods of detecting a cancer cell, cancer tissue, or cell associated with a hyperproliferative disorder. In some embodiments, the method comprises a step of detecting the presence or absence of a modified substrate or portion thereof in urine of an animal without an instrument and solely by visual inspection of the urine. | 2016-02-04 |
| 20160033486 | SAMPLE ANALYSIS DEVICE AND CAPTURING METHOD FOR EXOSOMES - A recessed portion and a protruding portion arranged periodically are formed on a base portion. In the recessed portion, an antibody that binds to an antigen existing on a surface of each exosome to be detected is immobilized and then caused to bind to the exosomes. The width of the protruding portion is smaller than the average particle diameter of the exosomes. | 2016-02-04 |
| 20160033487 | DISPENSING DEVICE, IMMUNOASSAY ANALYZER AND METHOD THEREOF - Dispensing devices and methods are provided. The dispensing devices can include a first dispensing station arranged on a periphery of a holding unit for dispensing a first reaction component, and a second dispensing station arranged on the holding unit for dispensing a second reaction component. The first reaction component and the second reaction component are dispensed. Operations on the holding unit are not affected by dispensing of the first reaction component, improving test efficiency. Because reaction containers do not need to be transferred out of the holding unit to dispense the second reaction component, test processes are simplified, In addition, the dispensing unit is not restricted to being arranged around the holding unit, and the first dispensing unit and second dispensing unit are arranged separately, so restriction of and interference with the dispensing units are avoided. | 2016-02-04 |
| 20160033488 | Assay Enhancement by Selective Deposition and Binding on Amplification Structures - This disclosure provides, among other things, a method for enhancing detection of an analyte that is bound to a substrate comprising a signal amplification layer on a surface of the substrate, wherein the signal amplification layer comprises high-amplification regions and low-amplification regions, and the high-amplification regions amplify signals at said surface more than the low-amplification regions. The method comprises selectively masking the low-amplification regions of the substrate, thereby increasing the probability that an analyte will bind to a high-amplification region and be detected. | 2016-02-04 |
| 20160033489 | Haptenes and Conjugates Derived from Pyocyanin, Antibodies Thereof, and Immunichemical Method for Detecting Infections Caused by Pseudomonas Aeruginosa - The present invention relates to a compound of general formula I and to the use thereof as a hapten. | 2016-02-04 |
| 20160033490 | Linked Peptide Fluorogenic Biosensors - Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide. The fluorogen-activating peptide and blocking peptide are covalently linked in certain embodiments through a peptide linker. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by a cognate enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal. | 2016-02-04 |
| 20160033491 | MULTIPHASE MICROARRAYS AND USES THEREOF - The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous two-phase system for solution microarrays and uses thereof. Additional embodiments are described herein. | 2016-02-04 |
| 20160033492 | Apparatus for Manipulation and Detection of Magnetic Particles - The present invention pertains to the manipulation and detection of magnetically susceptible components and includes methods of manipulation and detection of magnetically susceptible components and apparatuses for the manipulation and detection of magnetically susceptible components. The apparatuses and systems of the present invention employ controllable magnetic fields to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel that is subject to interrogation by a detector system. The methods of the present invention employ controllable magnetic fields to specifically locate magnetically susceptible components in regions of a reaction vessel suitable for interrogation by a detector system. | 2016-02-04 |
| 20160033493 | FILTRATION DEVICE FOR ASSAYS - A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed. | 2016-02-04 |
| 20160033494 | MAGNETIC NANOSENSOR COMPOSITIONS AND BIOANALYTICAL ASSAYS THEREFOR - Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors. | 2016-02-04 |
| 20160033495 | Detection of Non-Nucleic Acid Analytes Using Strand Displacement Exchange Reactions - The present invention relates to an analyte detection system for detecting analytes different from DNA and RNA. The system comprises a set of oligonucleotides which may hybridize to each other in specific ways and is able to generate a signal based on the specific hybridization events. The system relies on changes in the hybridization equilibrium between the oligonucleotides in the presence of an analyte or analytes, which results in a change in signal. | 2016-02-04 |
| 20160033496 | Analyte Detection Enhancement by Targeted Immobilization, Surface Amplification, and Pixelated Reading and Analysis - This disclosure provides, among other things, a method of sample analysis, that comprises: (a) binding target analytes to capture agents that are attached to a surface of a plate, wherein the plate comprises (i) a sensing amplification layer comprises nanostructures that enhance signals and (ii) the capture agents are attached to said sensing amplification layer; (b) reading the plate with a reading device to produce an image of signals that represent individual binding events; and (c) identifying and counting individual binding events in an area of the image, thereby providing an estimate of the amount of one or more analytes in the sample. A system for performing the method is also provided. | 2016-02-04 |
| 20160033497 | Luminescence methods and reagents for analyte detection - The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using first analyte binding molecule labeled solid phase support encapsulated with chemiluminescent dye and chemiluminescent reaction generating molecule or enzyme coupled with second analyte binding molecules such as antibody HRP conjugate to detect specific analyte molecules. Another aspect of the current invention is that the analyte binding molecule labeled solid phase support encapsulated with chemiluminescent dye is magnetic. | 2016-02-04 |
| 20160033498 | NANOSENSORS AND RELATED TECHNOLOGIES - The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like. | 2016-02-04 |
| 20160033499 | BIOSAMPLE PLATE WITH DATA STORAGE AND WIRELESS COMMUNICATIONS - Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing biosample identification and analysis data, and a wireless communication interface for transferring the data to and from the biosample plate. In one embodiment, the biosample plate comprises a base for receiving a biosample, a memory component coupled to the base for storing identification and analysis information related to the biosample, and a wireless communication interface coupled to the memory component for transferring the information to and from the memory component. The wireless communication interface may include an optical device. | 2016-02-04 |
| 20160033500 | DEVICE, NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM, AND METHOD FOR DETERMING TYPE OF TARGET PEPTIDE - Disclosed is a device for determining a type of target peptide includes: an acquisition unit that obtains first to third information on a target peptide contained in a test sample; a storage unit that stores first to third information on a known peptide obtained using a standard sample containing the known peptide; and a controller programmed to perform operations including: comparing the first to third information on the target peptide obtained from the test sample with the first to third information on the known peptide stored in the storage unit; and determining whether or not the target peptide is the known peptide, wherein the first information is a dissociation rate constant when the target peptide dissociates from a protein, in a solid phase carrier in which the target peptide is immobilized on a support through the protein binding to a peptide, the second information is a maximum value of a layer thickness change amount on the support, and the third information is information indicating that a dissociation mode of a peptide and the protein is either a single dissociation mode or a multiple dissociation mode. | 2016-02-04 |
| 20160033501 | TEST KIT - The present invention provides a test kit capable of rapid and highly sensitive detection. | 2016-02-04 |
| 20160033502 | COMPOSITIONS AND METHODS FOR DETECTION OF PROTEIN S-NITROSYLATION AND OXIDATION - The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods. | 2016-02-04 |
| 20160033503 | METHOD OF CAPTURING BACTERIA ON POLYLYSINE-COATED MICROSPHERES - The present disclosure relates to compositions, methods, and kits for the detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using polylysine-coated particles to capture microorganisms such as bacteria. | 2016-02-04 |
| 20160033504 | PROTOCOL FOR IDENTIFYING AND ISOLATING ANTIGEN-SPECIFIC B CELLS AND PRODUCING ANTIBODIES TO DESIRED ANTIGENS - Methods of identifying antigen-specific antibody-secreting and antibody-forming cells, such as antigen-specific B cells, and methods for cloning the antigen-specific antibody sequences of the antibody produced by these cells are provided. In particular, the methods include enriching B cells for antigen-specific B cells, culturing the antigen-specific B cells to generate clonal B cell populations, detecting clonal B cells that produce a single antigen-specific antibody, optionally screening the clonal B cell populations for functional activity, staining and sorting the cells to isolate the antigen-specific B cells, sequencing the nucleic acids encoding the antigen-specific antibody sequences, expressing the sequences to produce an antibody, isolating the antibody and screening the antibody for antigen recognition. The methods provide improved enrichment and selection of antigen-specific antibody-secreting and antibody-forming cells, which enhances recovery of antigen-specific antibodies. | 2016-02-04 |
| 20160033505 | Mobile Phase Test Strip Components, Conjugate Pad Pre-treatment Solutions, And Related Methods Thereof - A mobile phase test strip component is described herein including a conjugate pad. The conjugate pad includes a gold solution antibody having an antibody loading concentration of approximately 4 μg/OD and a gold OD of 5 to 6. The gold solution antibody is conjugated with a TRIS buffer solution and re-suspended with a dispensing buffer. The conjugate pad can include a high density polyester fiber pad material. A conjugate pad pre-treatment solution is also described, including at least one protein, at least one surfactant, at least one metal cation, and at least one polymer. A method for pre-treating a conjugate pad is also described. | 2016-02-04 |
| 20160033506 | METHODS OF MEASURING ADAMTS 13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF - The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. | 2016-02-04 |
| 20160033507 | USE OF ACY-1 AS A MARKER OF ISCHAEMIA/REPERFUSION, DELAYED GRAFT FUNCTION AND GRAFT VIABILITY AS WELL AS METHOD THEREOF - The invention relates to use of ACY-1 as a biomarker for ischaemia-reperfusion injury. | 2016-02-04 |
| 20160033508 | CIRCULATING TUMOR CELL DIAGNOSTICS FOR PROSTATE CANCER BIOMARKERS - The present invention describes a method for detecting castration-resistant prostate cancer (CRPC) in a patient afflicted with prostate cancer comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to detect circulating tumor cells (CTC), (b) determining prevalence of a CTC subpopulation associated with CRPC comprising detecting a measurable feature of each biomarker in a panel of morphological and protein biomarkers, and (c) comparing the prevalence of said CTC subpopulation to a predetermined threshold value, wherein the prevalence of the CTC subpopulation associated with CRPC above said predetermined threshold value is indicative of CRPC. In some embodiments, the CTC subpopulation associated with CRPC comprises CK− CTCs. In some embodiments, the CTC subpopulation associated with CRPC comprises small CTCs. In additional embodiments, the methods of the invention further comprise molecular analysis of the CTCs. | 2016-02-04 |
| 20160033509 | DIAGNOSTIC AND PROGNOSTIC MARKER FOR PROSTATE CANCER - Provided herein are methods for determining a diagnosis and/or prognosis for prostate cancer using the ratio of FOXC1:FOXA1 in a sample obtained from a subject. | 2016-02-04 |
| 20160033510 | ANTIBODIES FOR THE IDENTIFICATION OF PANCREATIC DISORDERS - Levels of VEGF-A, VEGF-C and PGE | 2016-02-04 |
| 20160033511 | METHODS AND COMPOSITIONS FOR DETECTING PANCREATIC CANCER - The present invention relates to non-invasive methods for the diagnosis and prognosis of pancreatic cancer. In some embodiments, such methods and compositions relate to particular pancreatic cancer biomarkers and combinations thereof. | 2016-02-04 |
| 20160033512 | DIAGNOSIS OF CARCINOMAS - The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages. | 2016-02-04 |
| 20160033513 | USE OF CD36 TO IDENTIFY CANCER SUBJECTS FOR TREATMENT - Provided herein are methods for identifying a subject with cancer for treatment with a Psap peptides. The subject is identified based on a level of CD36. Also provided herein are compositions and methods for treatment of a subject with cancer based on a level of CD36. | 2016-02-04 |
| 20160033514 | BIOMARKERS OF IMMUNOMODULATORY EFFECTS IN HUMANS TREATED WITH ANTI-CD200 ANTIBODIES - The present disclosure relates to anti-CD200 antibodies (e.g., variant anti-CD200 antibodies having decreased or no effector function) and to biomarkers for use in a variety of diagnostic and therapeutic methods, e.g., determining whether a human has been administered one or more of the antibodies at a dose sufficient to induce a desired immunomodulatory effect in the human and/or selecting an appropriate dosing schedule for a patient. | 2016-02-04 |
| 20160033515 | USE OF FACILITATES CHROMATIN TRANSCRIPTION COMPLEX (FACT) IN CANCER - The present invention relates to, inter alia, measuring of at least one component of the facilitates chromatin transcription complex (FACT) for evaluating a tumor, including, for example, determining the aggressiveness of a tumor and directing treatment. | 2016-02-04 |
| 20160033516 | USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES SPECIFIC FOR 3-PHOSPHOHISTIDINE - Isolated monoclonal antibodies and antigen binding fragments are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides comprising a histidine phosphorylated at N3 (3-pHis), detection of a tumor, monitoring the effectiveness of therapeutic agent, and identifying antibiotics. In some embodiments, the methods can be used to investigate signal transduction pathways. | 2016-02-04 |
| 20160033517 | ELISA FOR VEGF - The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index. | 2016-02-04 |
| 20160033518 | BIOMARKER PNCK FOR PREDICTING EFFECT OF A DUAL-TARGETING AGENT - A biomarker PNCK for predicting an efficacy of a dual-targeting agent that targets both c-Met and EGFR and a method of predicting an effect of a dual-targeting agent that targets both c-Met and EGFR, selecting the subject for application of a dual-targeting agent that targets both c-Met and EGFR, or monitoring an effect of a dual-targeting agent that targets both c-Met and EGFR, including measuring a level of a PNCK and/or a PNCK coding gene. | 2016-02-04 |
| 20160033519 | BROMODOMAIN BINDING REAGENTS AND USES THEREOF - The present invention provides compounds of the Formula (I) and (II), and salts thereof, wherein L | 2016-02-04 |
| 20160033520 | FLUORESCENT COMPOUNDS - The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions. | 2016-02-04 |
| 20160033521 | FLUOROPHORE AND FLUORESCENT SENSOR COMPOUND CONTAINING SAME - The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety: | 2016-02-04 |
| 20160033522 | METHYLCITRATE ANALYSIS IN DRIED BLOOD SPOTS - There is provided a method of measuring methylcitrate (MCA) in a sample by derivatizing the MCA, for example with 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole (DAABD-AE); measuring a level of the derivatized MCA; and determining the level of MCA from the measured level. The sample may be a dried blood spot (DBS), and the extraction and derivatization may be carried out simultaneously. No separate extraction or purification step is required, thereby reducing sample handling. Measuring may be carried out by mass spectrometry. The method may be used to screen for subjects having or at increased risk of a propionylcarnitine (C3) related disorder. The method may be used as a first tier screen, or as a second tier test for a sample that previously triggered a positive result in a primary screen. The method may be applied to newborn screening. Related kits and uses are also provided. | 2016-02-04 |
| 20160033523 | PHARMACOKINETIC ANIMAL MODEL - The present invention relates to a method of assessing pharmacokinetic properties of a variant of human serum albumin using a non-primate animal species where the native albumin of the animal provides minimal competition for HSA binding to the FcRn receptor in said animal. In the non-primate animal species, the binding affinity of wild type HSA to the native FcRn of said animal is the same as or higher than the binding affinity of the native albumin of said animal to the native FcRn. The present invention also relate to animal models which are particularly suitable for assessing pharmacokinetics of human serum albumin variants. | 2016-02-04 |
| 20160033524 | Methods of Detecting Donor-Specific Antibodies and Systems for Practicing the Same - Provided are methods for determining the presence or absence of donor specific antibodies in a biological sample. The methods include mixing a cellular sample from a donor with a biological sample from a recipient under conditions sufficient for recipient immune antibodies, if present, to bind to donor cell surface antigen (Ag) to form an immune antibody-Ag complex, contacting the mixture with beads comprising an antibody that specifically binds the immune antibody-Ag complex (e.g., the Ag or immune antibody) on a surface thereof, adding under lysis conditions a detectably-labeled antibody that specifically binds the immune antibody-Ag complex bound to the beads, and detecting the presence or absence of the detectably-labeled antibody bound to the immune antibody-Ag complex to determine the presence or absence of donor specific antibodies in the biological sample from the recipient. Systems and kits for practicing the subject methods are also provided. | 2016-02-04 |
| 20160033525 | IMMUNOASSAY STANDARDS AND MEASUREMENT OF TAU USING INTRA-ASSAY CALIBRATION STANDARDS - The present invention provides novel peptides, compositions, and methods for creating quantitative novel compositions, as well as methods for creating quantitative standards to calibrate analytes. These peptides, compositions, and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers (e.g., Tau). Also provided are kits comprising the peptides or compositions described herein, for use in assays (e.g., sandwich immunoassays). | 2016-02-04 |
| 20160033526 | Method for Analyzing Samples of a Biological Fluid and Apparatus for Performing the Same - The present invention relates to methods for continuous or near-continuous separation and purification of samples, particularly biological samples, to reduce the number or volume of non-targeted analytes in those samples to enable improved mass spectrometric analysis of analytes of interest, and apparatuses for conducting those methods, utilizing a transport agent with a core domain and a binding domain, the transport agent exceeding 200 kiloDaltons or 10 nm, and the binding domain targeted to the analytes of interest, in conjunction with size-exclusion based chromatography to separate the transport agent-analyte of interest complex from non-targeted analytes that are not bound, or are only non-specifically bound, to the transport agent. | 2016-02-04 |
| 20160033527 | SYSTEM AND METHOD FOR DETERMINING AMINO ACID SEQUENCE OF POLYPEPTIDE - This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers. Then, the systems and method are used to separate the short peptides and the amino acid enantiomers, identify qualitatively each of the amino acid enantiomers, and obtain the molecular mass signal for each of the peptides. After that, the identified amino acid enantiomers are used to construct any possible short peptides in an order from the smallest molecular weight dipeptide to higher molecular weight short peptides, and the correct short peptides is confirmed by matching the molecular weight obtained from the mass spectrometry measurement, then, the short peptides are combined to give a large peptide. The process is continued until the whole amino acid sequence of the peptide chain of protein can be determined. | 2016-02-04 |
| 20160033528 | Methods for Selecting Peptides that Bind to Disease Specific Antibodies, Disease Specific Peptides and Uses Thereof - Provided herein is a method for selecting and expanding polypeptide epitopes against disease-specific antibodies present in blood across a wide variety of antibody-mediated infectious and autoimmune diseases. In particular, high-throughput selection methods are provided for selecting and expanding disease-relevant polypeptide epitopes against disease-specific antibodies present in a sample from a subject using polypeptide epitope libraries. Also provided are polypeptide epitope sequences, which accurately discriminate subjects with active and remitting Celiac Disease compared to non-Celiac subjects for diagnostic or therapeutic purposes. These peptide epitopes can be employed in methods for diagnosing a subject with Celiac disease. Kits useful in the disclosed methods are also provided. | 2016-02-04 |
| 20160033529 | USE OF AKT PHOSPHORYLATION AS A BIOMARKER FOR PROGNOSING NEURODEGENERATIVE DISEASES AND TREATING SAME - The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers. | 2016-02-04 |
| 20160033530 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI), for example, an antibody, comprising: a) providing a eukaryotic cell comprising (i) a nucleic acid encoding the POI, and (ii) a nucleic acid encoding a cell surface capture molecule, which comprises a membrane anchor and is capable of binding the POI; (b) culturing the cell under conditions in which the POI and cell surface capture molecule are expressed, and a POI-cell surface capture molecule complex is formed intracellularly and displayed on the cell surface; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 2016-02-04 |
| 20160033531 | METHOD AND COMPOSITIONS FOR DETECTING BINDING TO THE PREGNANE X RECEPTOR - In one aspect, the invention relates to compounds useful as fluorescence assay probes, methods of making same, and methods of using same to assay ligand binding interactions with PXR. In various aspects, the invention pertains to compositions comprising a polypeptide comprising a pregnane X receptor polypeptide, or a ligand binding fragment polypeptide thereof; and a molecule comprising a BODIPY residue and a vinca alkaloid residue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2016-02-04 |
| 20160033532 | MAMMALIAN PROTEIN CO-RECOGNITION BY BROADLY NEUTRALIZING ANTIBODIES AS MODIFIED IMMUNOGENS FOR RE-ELICITATION - The present invention relates to using HIV-1 broadly neutralizing antibodies to screen for glycan-dependent or protein-dependent self reactivities inherent in these mutated antibodies, and defining this cross recognition at the molecular level, and utilizing the information to re-elicit trimer-specific and/or N-glycan-dependent or protein-surface-dependent broadly neutralizing antibodies and therapeutic applications thereof. | 2016-02-04 |
| 20160033533 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA - The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic. | 2016-02-04 |
| 20160033534 | Measurement Of FGF21 As A Biomarker Of Fructose Metabolism And Metabolic Disease - The invention provides, inter alia, methods of monitoring the fructose response of a subject by determining the level of fibroblast growth factor 21 (FGF21) gene expression product in a biological sample (such as a serum sample) from the subject, where the subject was previously administered a fructose bolus. The invention also provides methods of monitoring the response of a subject to a treatment for a disorder of metabolism, for discriminating fructose intolerance from other gastrointestinal disorders not associated with fructose intolerance, for identifying a subject at risk for developing a disorder of metabolism, as well as methods of treatment for a disorder of metabolism. | 2016-02-04 |
| 20160033535 | Methods for the Diagnosis of Amyotrophic Lateral Sclerosis - The present invention is directed to systems and methods for diagnosing amyotrophic lateral sclerosis (ALS) by assessing the expression level of a marker, FGGY. In other aspects, the present invention is also directed to systems and methods of establishing a prognosis of ALS disease severity by assessing the expression level of FGGY. | 2016-02-04 |
| 20160033536 | NOVEL GROUPS OF BIOMARKERS FOR DIAGNOSING ALZHEIMER'S DISEASE - The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples. | 2016-02-04 |
| 20160033537 | Progressive Approximation of Sample Analyte Concentration - Error may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The closer the analysis-determined pseudo-reference analyte concentration is to the reference analyte concentration of the test sample, the more accurate and/or precise the analyte concentration determined by the measurement device using an anchor parameter during compensation. The present invention provides an improvement in the accuracy and/or precision of the analysis determined pseudo-reference concentration through progressive approximation. | 2016-02-04 |
| 20160033538 | METHOD OF SELECTING ANTIOXIDANTS FOR USE IN TOPICALLY APPLIED COMPOSITIONS - Antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. Methods for testing a composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum. Compositions and methods for treating and preventing photodamage to skin. | 2016-02-04 |
| 20160033539 | SYSTEM AND METHOD OF COMPONENT ANALYSIS AND AUTOMATIC ANALYSIS DEVICE USING SAME - A component analysis method of an automatic analysis device is provided. The automatic analysis device includes an incubation unit that holds at least one reaction container and a plurality of executing stations set around the incubation unit to correspondingly perform a plurality of analysis operations to the reaction container. The component analysis method sets a transport period of the incubation and a chronological sequence of the analysis operations, controls the incubation unit to transport the reaction container a first transport distance during the regular transport sub-period and transport the reaction container a second transport in the self-adaptive transport sub-period, and performs at least one regular operation to the reaction container in the regular transport sub-period and at least one self-adaptive operation to reaction container in the | 2016-02-04 |
| 20160033540 | Adjustable Robotic Picker For Laboratory Containers - A robotic picker with a pick head unit for a robotic tube handler that provides for automated transport and sampling of laboratory tubes, the picker having a prong picker with a multiple of depending pick prongs optimized for an orthogonal arrangement of tubes, typically in a tube rack, wherein the pick head unit has a mechanism for shifting the radial orientation of the pick head unit to accommodate both orthogonal and diagonal arrangements of laboratory tubes. | 2016-02-04 |
| 20160033541 | CALIBRATION PROCESS AND SYSTEM - An improved calibration process for a medical testing machine. The machine automatically recognizes that a package of calibration material has been inserted into it, and performs a calibration sequence to ascertain a calibration parameter to be used in performing future tests with the medical testing machine. The calibration package may include machine-readable indicators that the package is to be used for calibration, and of a calibration setpoint of a calibration material in the package. A calibration material may be stored in a lyophilized state in the package, and the medical testing machine may automatically reconstitute the lyophilized material. | 2016-02-04 |
| 20160033542 | BIOSAMPLE PLATE WITH DATA STORAGE AND WIRELESS COMMUNICATIONS - Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing biosample identification and analysis data, and a wireless communication interface for transferring the data to and from the biosample plate. In one embodiment, the biosample plate comprises a base for receiving a biosample, a memory component coupled to the base for storing identification and analysis information related to the biosample, and a wireless communication interface coupled to the memory component for transferring the information to and from the memory component. The wireless communication interface may include an electromagnetic device. | 2016-02-04 |
| 20160033543 | APPARATUS AND METHOD FOR AUTOMATED SAMPLE PREPARATION AND ADAPTOR FOR USE IN THE APPARATUS - There is provided an automated biological-sample-processing system comprising a pipette, a column of solid-phase material to which nucleic acid binds, a transport apparatus, an air-piston apparatus and an adaptor for coupling the pipette to the transport apparatus and to the air-piston apparatus, in which the adaptor is removably engageable with the transport apparatus and the air-piston apparatus for movement with the transport apparatus during processing of the sample, is couplable to the pipette so that the transport apparatus is controllable to position the pipette and so that the air-piston apparatus is controllable to draw a liquid into the pipette and to expel the liquid from the pipette, and is engageable with the column, in which the adaptor comprises a filter for preventing liquid or aerosol transfer between the pipette or column and the air-piston apparatus. | 2016-02-04 |
| 20160033544 | SYSTEMS AND METHODS FOR MULTI-ANALYSIS - Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. | 2016-02-04 |
| 20160033545 | ANEMOMETER DETECTING THERMAL TIME CONSTANT OF SENSOR - An anemometer and method for analyzing fluid flow is described. In one embodiment, a transistor sensor is heated by applying power to cause its base-emitter junction to rise from an ambient first temperature to a second temperature. The power is removed, and the Vbe is measured at intervals as the junction cools. The Vbe equates to a temperature of the junction. The temperature exponentially decreases, and the time constant of the decay corresponds to the fluid flow velocity. A best fit curve analysis is performed on the temperature decay curve, and the time constant of the exponential decay is derived by a data processor. A transfer function correlates the time constant to the fluid flow velocity. The transistor is thermally coupled to a metal rod heat sink extending from the package, and the characteristics of the rod are controlled to adjust the performance of the anemometer. | 2016-02-04 |
| 20160033546 | WATER RESISTANT AIRCRAFT PITOT DEVICE - A pitot tube system having a pitot tube containing a porous hydrophobic fabric that blocks water and contaminants from reaching a pressure sensor. The distance in the pitot tube between the fabric and a front orifice of the tube is less than 2.4 times the height of the orifice, and preferably less than or equal to 0.38 times the height. The section of the tube through which the fabric extends defines an opening characterized by a minimum dimension greater than 0.15 inches, and preferably being at least 0.21 inches. The tube is a removable structure that attaches to a mount that forms a passage for communicating the pressure in the tube. That passage contains a second porous hydrophobic fabric that also blocks water and contaminants from reaching a pressure sensor. | 2016-02-04 |
| 20160033547 | Method and Apparatus of Physical Property Measurement Using a Probe-Based Nano-Localized Light Source - An apparatus and method of performing physical property measurements on a sample with a probe-based metrology instrument employing a nano-confined light source is provided. In one embodiment, an SPM probe tip is configured to support an appropriate receiving element so as to provide a nano-localized light source that is able to efficiently and locally excite the sample on the nanoscale. Preferably, the separation between the tip apex and the sample during spectroscopic measurements is maintained at less than 10 nm, for example, using an AFM TR Mode control scheme. | 2016-02-04 |
| 20160033548 | INSPECTION METHOD AND ITS APPARATUS FOR THERMAL ASSIST TYPE MAGNETIC HEAD ELEMENT - To detect near-field light, which is generated by a thermal assist type magnetic head element, and leaking light with high sensitivity and to more accurately obtain the spatial intensity distribution of a near-field light generation area, an inspection apparatus for a thermal assist type magnetic head element is adapted so that a distance between a cantilever and the surface of a specimen and the excitation amplitude of the cantilever are set to be small to detect near-field light with high sensitivity by the suppression of an influence of other light components, a distance between the cantilever and the surface of the specimen and the excitation amplitude of the cantilever are set to be large to detect other light components present in the vicinity of near-field light with high sensitivity by the suppression of an influence of the amount of detected near-field light when other light components are measured. | 2016-02-04 |
| 20160033549 | FLEXIBLE NEAR FIELD OPTICAL IMAGING DEVICE INCLUDING FLEXIBLE OPTICAL HEAD WITH THIN FILM LAYER FOR FORMATION OF DYNAMIC OPTICAL NANO APERTURES - A near field optical imaging device includes: a light source for radiating light of a far field optical system; and an optical head including thin film layer for formation of dynamic optical nano apertures, combined with a measured object in one piece to generate a near field by a beam radiated from the light source, in which the measured object can be scanned in a depth direction by adjusting a depth of the near field, and the depth of the near field is adjusted by modifying a shape of an opening of the thin film layer for formation of dynamic optical nano apertures by adjusting an amount of the light radiated from the light source. | 2016-02-04 |
| 20160033550 | CONDUCTIVE ATOMIC FORCE MICROSCOPE AND METHOD OF OPERATING THE SAME - A conductive atomic force microscope including a plurality of probe structures each including a probe and a cantilever connected thereto, a power supplier applying a bias voltage, a current detector detecting a first current flowing between a sample object and each of the probes and a second current flowing between a measurement object and each of the probes, and calculating representative currents for the sample and measurement objects based on the first and second currents, respectively, and a controller calculating a ratio between representative currents of the sample object measured by each of the probe structures, calculating a scaling factor for scaling the representative current with respect to the measurement object measured by each of the probes, and determine a reproducible current measurement value based on the second measurement current and the scaling factor may be provided. | 2016-02-04 |
| 20160033551 | SOCKET FOR TESTING SEMICONDUCTOR DEVICE - A socket for testing a semiconductor to electrically connect electrodes of a test device and contact balls of a semiconductor device with each other, including: contactors each of which has an upper end portion protruding to one side from a vertical line and a lower end portion protruding to the other side in such a way as to have elasticity by a structure that the upper end portion and the lower end portion are symmetric with each other; insulation parts each of which is made of an insulating elastic material and is formed integrally with the contactor to absorb the force generated when coming in contact with the contactor; and guide films each of which is made with an insulating elastic body and is formed on an upper layer of the insulation part in order to align the contact balls of the semiconductor device and the contactors. | 2016-02-04 |
| 20160033552 | PROBE UNIT, METHOD OF MANUFACTURING PROBE UNIT, AND TESTING METHOD - A probe unit includes a probe pin and a support unit supporting the probe pin. The support unit includes first and second arms disposed at a distance along a direction in which the probe pin probes a probed object; a holding unit holding base ends of the arms; and a linking unit attached to the probe pin and linking front ends of the arms. The support unit constructs a four-bar linkage that permits linear or approximately linear movement of the probe pin in an opposite direction to the probing direction. The first and second arms have through-holes at positions slightly closer to the front ends than the base ends and positions slightly closer to the base ends than the front ends, center parts between the through-holes function as bars in the four-bar linkage, and formation positions of the through-holes function as joints in the four-bar linkage. | 2016-02-04 |
| 20160033553 | INTELLIGENT ELECTRICAL CIRCUIT DIGITAL AMPERAGE DISPLAY INTERFACE - An intelligent electrical circuit digital amperage display interface apparatus is disclosed. In use, the old style circuit breaker is replaced with the new apparatus for connecting electrical panels and using the apparatus of the present invention, displays the amperage that travels through a standard circuit breaker out to a device under use which shows the load on that circuit's line, twenty-four hours a day. In use, the apparatus allows the user (homeowner, landlord, utilities staff and anyone else) the capability to see what the amperage being used at any given moment in time as that circuit is being used or not. Additionally, a digital display integration interface is provided within the electrical circuit breaker for displaying to a user the smallest of amperage to the largest of amperage that is being used on any given circuit. | 2016-02-04 |
| 20160033554 | A CORELESS CURRENT PROBE AND A METHOD OF MEASURING CURRENT - A coreless current probe has a body defining an opening in a plane and a central line through the opening which is normal to the plane. A conductor carrying a current to be measured can be accommodated in the opening. At least three coreless single point magnetic field sensors are distributed in the body around the opening. The linear spacings between adjacent sensors around the opening are not all the same. In another embodiment, the sensors are not all located on a common cylindrical surface. One embodiment has a U-shaped body enabling engagement with a current carrying conductor. The sensors are arranged so that the sum of the outputs each with appropriate weighting is zero in any homogenous field. The sensors outputs have differing weightings so as to maximize rejection by the probe of external magnetic fields. | 2016-02-04 |
