05th week of 2016 patent applcation highlights part 29 |
Patent application number | Title | Published |
20160032353 | IN VITRO ASSAY BUFFER FOR CAS9 - Provided herein is a reaction mixture comprising Cas9 and a non-ionic surfactant, e.g., a polyoxyethylene surfactant. In certain embodiments, the reaction mixture may comprise a Cas9 protein, a guide RNA, a salt, a buffering agent, a nucleic acid target and a non-ionic surfactant. Kits are also provided. In certain embodiments, a kit may comprise: a Cas9 protein; and a concentrated reaction buffer comprising salt, a buffering agent and a non-ionic surfactant. | 2016-02-04 |
20160032354 | METHOD FOR MEASURING INDOXYL SULFURIC ACID - It is an object of this invention to provide a simple measurement method capable of detecting indoxyl sulfuric acid in a sample rapidly and at high sensitivity. By causing sulfatase and tetrazolium salt to act on indoxyl sulfuric acid in a sample to generate a formazan dye, and then calculating the generation amount of the formazan dye, indoxyl sulfuric acid in the sample can be measured more simply, more rapidly, and at higher sensitivity as compared with former methods. | 2016-02-04 |
20160032355 | Detection and Classification of an Anticoagulant Using A Clotting Assay - In some embodiments, the invention provides methods for detecting and/or classifying an anticoagulant at a therapeutically relevant amount or higher in a patient, including subjecting a sample of a control blood component (known not to contain the anticoagulant) to a clotting assay in the presence of a Factor Xa reagent to obtain a control clotting measurement; and subjecting a sample of a blood component from a patient suspected of having the anticoagulant to the clotting assay in the presence of the Factor Xa reagent to obtain a patient clotting measurement, wherein the patient clotting measurement sample greater than the control clotting measurement indicates the presence of the anticoagulant at a therapeutically relevant amount or higher in the patient. In some embodiments, the invention includes methods for classifying an anticoagulant as an anti-Factor Xa or a direct thrombin inhibitor anticoagulant using a clotting assay in the presence of an ecarin reagent. | 2016-02-04 |
20160032356 | QUANTITATIVE ASSESSMENT FOR CAP EFFICIENCY OF MESSENGER RNA - The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly for mRNA synthesized in vitro. In some embodiments, the methods comprise chromatographic methods of quantifying capping efficiency and methylation status of the caps. | 2016-02-04 |
20160032357 | METHOD FOR RELATIVE QUANTIFICATION OF CHANGES IN DNA METHYLATION, USING COMBINED NUCLEASE, LIGATION, AND POLYMERASE REACTIONS - The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more methylated or unmethylated target nucleotide sequences in the sample is identified based on the detection. | 2016-02-04 |
20160032358 | METHOD FOR IMPROVED THERMOCYCLING OF LOW VOLUME NUCLEIC ACID AMPLIFICATION REACTIONS - A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module. | 2016-02-04 |
20160032359 | Methods for Generating Nucleic Acid Molecule Fragments Having a Customized Size Distribution - The invention provides methods for generating nucleic acid molecule fragments having a customized distribution. In one aspect, a method of generating nucleic acid fragments having a customized fragment size distribution is provided comprising obtaining a master pool of nucleic acid molecules to be fragmented; fragmenting at least two independent aliquots of the master pool of nucleic acid molecules in separate reactions, wherein the fragmentation conditions are identical except for a single variable. | 2016-02-04 |
20160032360 | A METHOD FOR A SINGLE CELL ANALYSIS OF TELOMERE LENGTH - The invention relates to a method for single cell analysis of relative telomere length using multiplex pre-PCR followed by a qPCR (SCT-pqPCR). | 2016-02-04 |
20160032361 | CENTRIFUGE CONFIGURATIONS - Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. | 2016-02-04 |
20160032362 | Method for Enriching Methylated CpG Sequences - Compositions and methods are provided for facilitating the enrichment of single-stranded DNA containing methylated CpG in a mixture containing methylated and unmethylated DNA. The compositions relate to methylation-binding protein domains that selectively bind to methylated single strand DNA. In embodiments of the invention, the methylated DNA is eluted in 0.4M-0.6M NaCl while the unmethylated single strand DNA is eluted in less than 0.4M salt. The ability to readily enrich for methylated DNA permits high throughput sequencing of the methylated DNA and identification of abnormal methylation patterns associated with disease. | 2016-02-04 |
20160032363 | METHODS FOR THE DIAGNOSIS AND TREATMENT OF INFLAMMATORY BOWEL DISEASE - There is provided methods and compositions to diagnose, classify and treat inflammatory bowel disease including ulcerative colitis and Crohn's disease by measuring the levels of certain bacterial taxa and proteins collected from the gut. | 2016-02-04 |
20160032364 | Ribosomal Ribonucleic Acid Hybridization for Organism Identification - The present disclosure relates to method of distinguishing between two or more species of one or more organisms in a sample, by contacting a biological sample comprising ribosomal ribonucleic acid (rRNA) with a set of antisense probes, wherein the set of probes contains at least one detectable probe that is specific for a target rRNA sequence of each species to be tested, and wherein the individual probes specific for each species comprises less than about 85% sequence identity; and, detecting hybridization between one or more of the probes and the rRNA, thereby distinguishing between two or more species in a sample. | 2016-02-04 |
20160032365 | METHODS OF IDENTIFYING AND QUANTIFYING BACTERIA IN CHEWING GUM - The invention is directed to methods of extracting nucleic acids from microorganisms or mammalian cells adhered to polymers that are malleable within a living organism and particularly malleable in the oral cavity of the living organism. The invention also provides for method of detecting and quantitating microorganisms that adhere to malleable polymers, such as chewing gum. | 2016-02-04 |
20160032366 | MULTIPLEX ASSAY FOR DETECTION OF BACTERIAL SPECIES IN BIOLOGICAL SAMPLES - The invention provides a rapid, accurate, sensitive, and low-cost detection method for screening a biological sample for one or more desired bacterial species. The inventive method employs a two-step multiplex real-time PCR assay that comprises an internal amplification control and specific primer sets to detect and discriminate bacterial species based the unique melting temperatures of specific DNA sequences of each strain. | 2016-02-04 |
20160032367 | Method for Detection of Target Nucleic Acid - An object of the disclosure of the present specification is to provide a method for detection of a target nucleic acid which allows construction of an effective detection system of a target nucleic acid. For this purpose, in the disclosure of the present specification, a first primer comprising an identification sequence complementary to a target sequence in a target nucleic acid and a tag addition sequence, and a second primer having a label are prepared. The first primer and the second primer are used for the target nucleic acid in a sample to amplify a chimeric DNA having a tag sequence and the label. The chimeric DNA is hybridized with a detection probe on a solid phase to obtain signal intensity information based on the label, and the target nucleic acid is detected based on the signal intensity information. | 2016-02-04 |
20160032368 | METHYLATION DETECTION - A real-time method of detecting the presence and/or amount of a methylated or unmethylated gene of interest in a DNA-containing sample, comprises the steps of (a) contacting the DNA-containing sample with a reagent which selectively modifies unmethylated cytosine residues in the DNA to produce detectable modified residues but which does not modify methylated cytosine residues (b) amplifying at least a portion of the methylated or unmethylated gene of interest using at least one primer pair, at least one primer of which is designed to bind only to the sequence of methylated or unmethylated DNA following treatment with the reagent, wherein at least one primer in the primer pair produces a detectable fluorescence signal during amplification which is detected in real-time (c) quantifying the results of the real-time detection against a standard curve for the methylated or unmethylated gene of interest to produce an output of gene copy number. | 2016-02-04 |
20160032370 | Methods of Elongating DNA - The present invention relates to methods of elongating chromosomes. Embodiments of the present disclosure are directed to methods of elongating DNA by immobilizing or attaching the DNA to a substrate. According to one aspect, naturally occurring DNA includes a nucleic acid and one or more factors bound thereto, and may be referred to herein as “starting DNA | 2016-02-04 |
20160032371 | MATRIX ARRAYS AND METHODS FOR MAKING SAME - A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array. | 2016-02-04 |
20160032372 | NOVEL COMPOSITIONS AND PROCESSES FOR ANALYTE DETECTION, QUANTIFICATION AND AMPLIFICATION - This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention. | 2016-02-04 |
20160032373 | SYSTEMS AND METHODS FOR MULTIPLEX ANALYSIS OF PCR IN REAL TIME - The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process. | 2016-02-04 |
20160032374 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length. | 2016-02-04 |
20160032375 | NUCLEIC ACID AMPLIFICATION - In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer. The polymer can include a sieving agent and/or a diffusion-reducing agent. | 2016-02-04 |
20160032376 | NUCLEOTIDE ANALOGS FOR SEQUENCING - Provided herein is technology relating to sequencing nucleic acids, but not exclusively, to compositions, methods, systems, and kits related to nucleotides comprising an electrochemically detectable moiety and one or more photolabile synthesis-inhibiting moieties. | 2016-02-04 |
20160032377 | MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES - Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same. | 2016-02-04 |
20160032378 | MODIFIED NUCLEOTIDES - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 2016-02-04 |
20160032379 | ENZYME-LINKED NUCLEOTIDES - Presented herein are polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules. Also presented are methods and systems using the polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules. | 2016-02-04 |
20160032380 | ELECTRON BEAM NUCLEIC ACID SEQUENCING - The present invention relates to compositions, methods, and uses for obtaining sequence information from nucleic acid molecules. | 2016-02-04 |
20160032381 | GENES AND POLYMORPHISMS ASSOCIATED WITH AMD - There is provided a method of screening for susceptibility to complement dysregulation in an individual, the method including screening for the presence or absence of a genetic profile characterized by polymorphisms in the genome of the individual associated with complement dysregulation. The presence of a genetic profile is indicative of the individual's risk of complement dysregulation. | 2016-02-04 |
20160032382 | Method for Diagnosing or Predicting a Non Syndromic Autosomal Recessive Optic Atrophy, or a Risk of a Non Syndromic Autosomal Recessive Optic Atrophy - The present invention relates to a method for diagnosing or predicting a non syndromic autosomal recessive optic atrophy, or a risk of a non syndromic autosomal recessive optic atrophy. | 2016-02-04 |
20160032383 | PANEL OF microRNA BIOMARKERS IN HEALTHY AGING - Methods are provided for determining if a subject is likely to develop an age-related disease based on miRNA signatures. Related methods of treatment are also provided. | 2016-02-04 |
20160032384 | USE OF SHROOM3 IN CHRONIC KIDNEY DISEASE AND CHRONIC ALLOGRAFT NEPHROPATHY - A method for identifying the risk of developing Chronic Allograft Nephropathy (CAN) in a patient that received a kidney transplant from a donor which comprises identifying the race of the donor; determining the levels of SHROOM 3 expression in a kidney biopsy specimen obtained from the patient at a predetermined time after transplant; comparing the level of SHROOM 3 expression in the biopsy specimen with the levels of SHROOM 3 expression in a control; determining if the level of SHROOM 3 expression in the allograft is significantly higher than in the control, and diagnosing the patient as being at risk for CAN if the level of SHROOM 3 expression in the specimen is significantly higher than in the control. | 2016-02-04 |
20160032385 | METHOD FOR DETECTING CYSTIC FIBROSIS - The present invention relates to methods for simultaneously determining the presence or absence of mutations, deletions, duplications and single nucleotide polymorphisms in a cystic fibrosis transmembrane regulator (CFTR) nucleic acid. Oligo nucleotide primers and kits used to amplify regions of a CFTR nucleic acid for high throughput, massively parallel sequencing and methods of determining an individual's cystic fibrosis status are also disclosed. | 2016-02-04 |
20160032386 | GENETIC MARKERS FOR OSTEOARTHRITIS - A method for predicting the severity or progression of OA in a human subject, comprising: determining the identity of at least one allele at each of at least 4 positions of single nucleotide polymorphism (SNPs) selected from the group consisting of: rs2206593, rs10465850, rs780094, rs1374281, rs1143634, rs2073508, rs2243250, rs4720262, rs917760, rs7838918, rs12009, rs730720, rs874692, rs893953, rs1799750, rs10845493, rs11054704, rs7986347, rs1802536, rs10519263, rs7342880, rs16947882 and rs10413815, and one or more SNPs in linkage disequilibrium at a level of at least R | 2016-02-04 |
20160032387 | METHODS AND SYSTEMS FOR EVALUATING GENES - Aspects and embodiments disclosed herein are directed to providing methods and systems for evaluating target genes and/or associated super enhancers and or super-enhance components. In some embodiments, the method includes selecting a gene associated with a super-enhancer, to provide a selected gene, evaluating the selected gene for contribution to a cell state, e.g., a state characterized by a disease or disorder (a disease/disorder state), and responsive to the evaluation, classifying the selected gene and/or associated super-enhancer. | 2016-02-04 |
20160032388 | GENETIC POLYMORPHISMS ASSOCIATED WITH LIVER FIBROSIS, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 2016-02-04 |
20160032389 | Method, Kits, and Reaction Mixtures For High Resolution Melt Genotyping - Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one nucleotide alteration. In some embodiments, a nucleic acid is provided comprising a SNP base located within 1-20 bases of its 3′ end. Some embodiments comprise hybridizing the locus specific primer and at least one of the allele specific primers to the nucleic acid, amplifying the hybridized nucleic acid using pyrophosphorolysis activated polymerization (PAP) PCR, and determining the melting temperature (Tm) of the resulting amplicons, for example, using HRM. In some embodiments, reaction mixtures and kits for HRM genotyping are provided. The reaction mixtures and kits can each comprise a locus specific primer, one or more allele specific primers each comprising at least one SNP allele-hybridizable sequence, and a PAP PCR enzyme, wherein at least one of the allele specific primers also comprises a nucleotide alteration, for example, a tail. | 2016-02-04 |
20160032390 | SCHIZOPHRENIA-ASSOCIATED GENETIC LOCI IDENTIFIED IN GENOME WIDE ASSOCIATION STUDIES AND METHODS OF USE THEREOF - Compositions and methods for the identification of agents useful for the treatment of neurological disorders, including schizophrenia, are provided. | 2016-02-04 |
20160032391 | METHOD OF ESTABLISHING A GENETIC RISK STRATIFICASTION FOR GENETIC ADDICTION RISK ANALYSIS - Methods and kits for assessing severity index for alcohol abuse, drug abuse, and other reward deficiency syndromes. It has been discovered that a multifaceted non-specific RDS behaviors should be considered as the true “reward” phenotype (endophenotype) instead of a single subset RDS behavior such as alcoholism. In an embodiment of the present invention, it has been discovered that there are at least eleven risk alleles associated with ten candidate genes. The methods and kits of the present invention satisfy the need to classify patients at genetic risk for drug/alcohol seeking behavior prior to or upon entry to residential and or non-residential chemical dependency and pain programs. | 2016-02-04 |
20160032392 | METHODS OF DIAGNOSING ENDOMETRIOSIS - The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis. | 2016-02-04 |
20160032393 | METHODS AND KITS FOR PREDICTING PROGNOSIS OF MULTIPLE SCLEROSIS - Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis. | 2016-02-04 |
20160032394 | METHOD FOR REVERSING RECENT-ONSET TYPE 1 DIABETES (T1D) BY ADMINISTERING SUBSTANCE P (sP) - Described herein is a treatment comprising the following step: (a) injecting a therapeutically effective amount of a pharmaceutical composition into the celiac artery of an individual, wherein the pharmaceutical composition reverses recent onset Type 1 Diabetes (T1D). Also described is a method for identifying an individual who will be responsive to this treatment. In addition there is described a device containing the pharmaceutical composition for injecting the pharmaceutical composition into the celiac artery. | 2016-02-04 |
20160032395 | CANCER BIOMARKERS AND CLASSIFIERS AND USES THEREOF - Disclosed herein, in certain instances, are methods, systems and kits for the diagnosis, prognosis and determination of cancer progression of a cancer in a subject. Further disclosed herein, in certain instances, are methods, systems and kits for determining the treatment modality of a cancer in a subject. The methods, systems and kits comprise expression-based analysis of biomarkers. Further disclosed herein, in certain instances, are probe sets for use in assessing a cancer status in a subject. Further disclosed herein are classifiers for analyzing a cancer. | 2016-02-04 |
20160032396 | Identification and Use of Circulating Nucleic Acid Tumor Markers - Methods for creating a selector of mutated genomic regions and for using the selector set to analyze genetic alterations in a cell-free nucleic acid sample are provided. The methods can be used to measure tumor-derived nucleic acids in a blood sample from a subject and thus to monitor the progression of disease in the subject. The methods can also be used for cancer screening, cancer diagnosis, cancer prognosis, and cancer therapy designation. | 2016-02-04 |
20160032397 | MAST CELL CANCER-ASSOCIATED GERM-LINE RISK MARKERS AND USES THEREOF - Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line risk markers. | 2016-02-04 |
20160032398 | METHODS FOR TREATING CANCER - The disclosure features a method of treating cancer by lowering a patient's two gene score (TGS), particularly by increasing the number of tumor-infiltrating leukocytes. In addition, a TGS animal model and uses thereof are provided. | 2016-02-04 |
20160032399 | Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis - The present invention relates to a method for the prognosis of bone metastasis in renal cell carcinoma which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering renal cell carcinoma. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of renal cell carcinoma metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering renal cell carcinoma and for classifying a subject from renal cell carcinoma into a cohort. | 2016-02-04 |
20160032400 | METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS - The present invention relates to a method for the prognosis of bone metastasis in cancer which comprises using a probe to determine if a gene of interest is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise using a probe to determine the expression level of a gene of interest, or the amplification or translocation of a gene of interest. The invention also relates to a method for predicting early bone metastasis in a subject suffering cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of cancer metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering cancer and for classifying a subject from cancer into a cohort. | 2016-02-04 |
20160032401 | Glycine, Mitochondrial One-Carbon Metabolism, and Cancer - Methods of treatment, diagnosis, and determining prognosis of subjects with cancer, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2, MTHFD1L, or MTHFD2, and optionally administering an antifolate or an agent that inhibits a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2 or MTHFD2. | 2016-02-04 |
20160032402 | BIOMARKERS ASSOCIATED WITH BRM INHIBITION - The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided. | 2016-02-04 |
20160032403 | DRUG SELECTION FOR NON-SMALL CELL LUNG CANCER THERAPY - The present invention provides methods for selecting a suitable anticancer drug for the treatment of patient with non-small cell lung cancer (NSCLC). The present invention also provides methods for determining drug resistance in NSCLC patients receiving EGFR inhibitor therapy. | 2016-02-04 |
20160032404 | BIOMARKERS FOR PREDICTING RESPONSE OF DLBCL TO TREATMENT WITH A BTK INHIBITOR - Disclosed herein, are methods, systems, compositions, arrays, and kits for using biomarkers, biomarker genes (e.g. EP300, MLL2, BCL-2, RB1, LRP1B, PIM1, TSC2, TNFRSF11A, SMAD4, PAX5, CARD11, ACTG2, LOR, GAPT, CCND2, SELL, GEN1, HDAC9, CD79B, MYD88, and ROS1) or biomarker gene expression levels for stratifying a patient having a hematological malignancy such as DLBCL for treatment, and administering a TEC inhibitor to selected patients. Also disclosed herein are methods, systems, compositions, arrays, and kits for using biomarkers, biomarker genes, or biomarker gene expression levels for monitoring a patient during treatment of a hematological malignancy such as DLBCL or FL or for optimizing a treatment regimen with a TEC inhibitor. | 2016-02-04 |
20160032405 | METHOD FOR IDENTIFYING OR DETECTING GENOMIC REARRANGEMENTS IN A BIOLOGICAL SAMPLE - A method for detection, visualization and/or comparison of polynucleotide sequences of interest using specially designed sets of long and short probes that enhance resolution and simplify visualization and detection. Probe compositions useful for practicing this method and procedures for identifying useful probes and probe combinations. These methods are useful for the detection of genomic rearrangements, especially those associated with various diseases, disorders and conditions including cancer or for assessment of genomic rearrangements associated with therapy. The probe compositions may be used in kits for detection of genetic rearrangements or in companion diagnostic products or kits, such as kits for the diagnosis or assessment of predisposition to cancer such as colorectal cancer. | 2016-02-04 |
20160032406 | Diagnostic Method Using PALB2/US - The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient. | 2016-02-04 |
20160032407 | PROGNOSTIC AND PREDICTIVE GENE SIGNATURE FOR NON-SMALL CELL LUNG CANCER AND ADJUVANT CHEMOTHERAPY - The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application. | 2016-02-04 |
20160032408 | Polynucleotide Primers For Detecting PIK3CA Mutations - A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers. | 2016-02-04 |
20160032409 | GENETIC LOCI ASSOCIATED WITH FROGEYE LEAF SPOT RESISTANCE AND BROWN STEM ROT RESISTANCE AND METHODS OF USE - Various methods and compositions are provided for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In certain embodiments, the method comprises detecting at least one marker locus that is associated with resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In other embodiments, the method further comprises detecting at least one marker profile or haplotype associated with resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In further embodiments, the method comprises crossing a selected soybean plant with a second soybean plant. Further provided are markers, primers, probes and kits useful for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to Frogeye Leaf Spot and/or Brown Stem Rot. | 2016-02-04 |
20160032410 | DETECTION AND USE OF ANTIVIRAL RESISTANCE MUTATIONS - The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein. | 2016-02-04 |
20160032411 | SELECTIVE DETECTION OF HEPATITIS A, B, C, D, OR E VIRUSES OR COMBINATION THEREOF - Processes and compositions are provided for the detection of hepatitis viruses in a sample. Particular processes and compositions are provided for the selective detection of HDV. Also provided are processes and compositions for the simultaneous detection of two or more hepatitis viruses that for the first time provide rapid, reliable, and simple detection of any known hepatitis vims in a sample using a single set of reaction conditions. | 2016-02-04 |
20160032412 | COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID - Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits. | 2016-02-04 |
20160032413 | NANOPRODUCT COMPRISING LACTOBACILLUS REUTERI DAN080 USEFUL IN PROPHYLAXIS AND MEDICINE, BOTH HUMAN AND VETERINARY AND MEDICAL USE OF THE SAME - The invention relates to a nanoproduct useful in prophylaxis and medicine, both human and veterinary as well as to a medical use of the same. The invention discloses | 2016-02-04 |
20160032414 | CARBON PURIFICATION OF CONCENTRATED SUGAR STREAMS DERIVED FROM PRETREATED BIOMASS - Provided are methods and compositions using activated carbon for optimizing purification and clarification of sugar streams produced from cellulosic or lignocellulosic biomass. Also provided are methods and compositions for decreasing one or more undesirable products during pretreatment. | 2016-02-04 |
20160032415 | Heat Treat Production Fixture - A method for manufacturing a metal structure ( | 2016-02-04 |
20160032416 | GAS TURBINE ENGINE AIRFOIL IMPINGEMENT COOLING - A method of manufacturing an airfoil includes the steps of depositing multiple layers of powdered metal onto one another. The layers are joined to one another with reference to CAD data relating to a particular cross-section of an airfoil. The airfoil is produced with leading and trailing edges joined by spaced apart pressure and suction sides to provide an exterior airfoil surface. An exterior wall provides the exterior airfoil surface at the leading edge. An impingement wall is integrally formed with the exterior wall to provide an impingement cavity between the exterior wall and the impingement wall. Multiple impingement holes are provided in the impingement wall. The impingement holes are spaced laterally across the impingement wall. | 2016-02-04 |
20160032417 | WORK HARDENABLE YIELD RATIO-CONTROLLED STEEL AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing yield ratio-controlled steel, including the steps of subjecting alloy steel to rolling or wire drawing, thus obtaining a bar material; performing a first heat treatment, in which the material is heated and maintained for a predetermined period of time at a first temperature ranging from A | 2016-02-04 |
20160032418 | METHOD FOR PRODUCING STEEL FOR BLADES - Disclosed is a method for producing steel for blades having a metal composition consisting of, by mass, 0.55% to 0.8% C, not more than 1.0% Si, not more than 1.0% Mn, 12.0% to 14.0% Cr, not more than 1.0% Mo, not more than 1.0% Ni, and the balance Fe with impurities, comprising: a batch annealing step for batch annealing a material to be cold rolled having the metal composition at a temperature of 500° C. to 700° C. for 3 to 30 hours; a continuous annealing step for continuously annealing the batch annealed material for 5 to 30 minutes so that the batch annealed material is heated to at least an Ac1 transformation point of the metal composition step to obtain a continuously annealed material; and a cold rolling step for cold rolling the continuously annealed material, wherein the continuous annealing step and the cold rolling step are performed at least once, respectively. | 2016-02-04 |
20160032419 | METHOD FOR SELECTIVELY RECOVERING THE RARE EARTHS FROM AN AQUEOUS ACID SULFATE SOLUTION RICH IN ALUMINUM AND PHOSPHATES - The present invention relates to a process for the selective recovery of the rare earth metals from an acidic aqueous sulfate solution comprising phosphates, aluminum and heavy rare earth metals, and possibly medium rare earth metals, iron(II) and titanium, characterized in that it comprises the following successive stages: a) neutralization at a pH of between 3 and 4 of an acidic aqueous sulfate solution comprising phosphates, aluminum and heavy rare earth metals, and possibly medium rare earth metals, iron(II) and titanium, the solution having a molar ratio Al/P>1 and a concentration of sulfates>100 g/l, by addition of a base, so as to precipitate the phosphate and the aluminum and the possible titanium, b) liquid/solid separation between the precipitate formed by the phosphate and the aluminum and the possible titanium and the aqueous sulfate solution, c) recovery of the aqueous sulfate solution, d) addition of phosphates to the aqueous sulfate solution obtained in stage c) such that the molar ratio of the solution obtained PO | 2016-02-04 |
20160032420 | METHODS FOR TREATING CARBON MATERIALS INCLUDING CARBONACEOUS ORES - Methods described herein generally relate to the treatment of carbonaceous materials with ozone to facilitate the subsequent recovery of metal species (e.g., precious metals) from the carbonaceous material. In some cases, the method may involve exposure of a carbonaceous material to a relatively low amount of ozone. In some cases, the carbonaceous material may be subjected to oxidizing conditions, e.g. by autoclaving or bio-oxidation, prior to ozone treatment. Such embodiments may allow for more simplified and cost-effective methods for metal recovery. | 2016-02-04 |
20160032421 | PROCESSES FOR TREATING FLY ASHES - There are provided processes for treating fly ash. For example, the processes can comprise leaching fly ash with HCl so as to obtain a leachate comprising aluminum ions and a solid, and separating the solid from the leachate; reacting the leachate with HCl so as to obtain a liquid and a precipitate comprising the aluminum ions in the form of AlCl | 2016-02-04 |
20160032422 | PROCESS FOR PREFERENTIAL DISSOLUTION OF IRON IN THE PRESENCE OF TITANIUM - Disclosed herein are processes for selectively solubilizing iron from a substrate material containing both titanium and iron, such as ilmenite ore. In one embodiment, the process comprises contacting a substrate material comprising iron and titanium with an aqueous solution of an extractant selected from the group consisting of malonic acid, a malonic acid salt, citric acid, a citric acid salt, and mixtures thereof, at a temperature between about 25° C. and about 160° C. for a time sufficient to form an aqueous leachate comprising iron and titanium, and solids comprising titanium; wherein the leachate has a titanium content of 25 weight percent or less, based on the sum of the iron and the titanium contents of the leachate on a weight basis. | 2016-02-04 |
20160032423 | A method for concentrating rare-earth metals in phosphogypsum - The present invention relates to a method for producing rare-earth metals (REM) compounds by complex processing of apatite, in particularly to a method for concentrating rare-earth metals (REM) in phosphogypsum, where to a process of decomposition of the REM containing raw phosphate material with sulphuric acid, a sodium salt in the amount of 0.25-5.0 kg in terms of Na | 2016-02-04 |
20160032424 | SOLDER ALLOY AND JOINT THEREOF - A silver electrode joint having a high joint strength obtained by actively minimizing the particle size of a silver-zinc intermetallic compound at the solidification point. A joint obtained by joining an article to be joined, the joint including silver at least as the surface layer thereof, using a solder alloy which comprises 2-9 wt % of zinc, 0.0001-0.1 wt % of manganese and the balance consisting of tin, the solder joint having a joint interface wherein the particle size of a silver-zinc intermetallic compound, which is formed by silver being the surface layer of the article to be joined and zinc in the solder alloy, is 5 μm or less. | 2016-02-04 |
20160032425 | NICKEL-BASED ALLOY WITH SILICON, ALUMINUM, AND CHROMIUM - A nickel-based alloy, consisting of (in mass %) 1.5-3.0% Si, 1.5-3.0% Al, and >0.1-3.0% Cr, where Al+Si+Cr is ≧4.0 and ≦8.0 for the contents of Si, Al, and Cr in %; 0.005-0.20% Fe, 0.01-0.20% Y, and <0.001-0.20% of one or more the elements Hf, Zr, La, Ce, Ti, where Y+0.5*Hf+Zr+1.8*Ti 0.6*(La+Ce) is ≧0.02 and ≦0.30 for the contents of Y, Hf, Zr, La, Ce, and Ti in %; 0.001-0.10% C; 0.0005-0.10% N; 0.001-0.20% Mn; 0.0001-0.08% Mg; 0.0001-0.010% O; max. 0.015% S; max. 0.80% Cu; Ni remainder; and the usual production-related impurities. | 2016-02-04 |
20160032426 | OPTIMIZED NICKEL ALLOY AND TURBINE BLADE MADE THEREOF - A nickel alloy includes a proportion by weight of Cr of 12.3% to 13.7%, a proportion by weight of Al of 4.3% to 4.7% and a proportion by weight of Co of 4% to 6%. The components are preferably Cr, Mo, Re and/or W, Al, Ti, Ta, Hf, Si, reactive elements including actinides and lanthanides, C, optionally the components Zr and/or B. The proportions by weight are selected such that both a desired high creep resistance and also a desired high hot corrosion resistance are achieved. A turbine blade is made of the nickel alloy. | 2016-02-04 |
20160032427 | METHOD FOR MANUFACTURING HIGH PURITY MANGANESE AND HIGH PURITY MANGANESE - The present invention relates to a method for manufacturing a high purity Mn, the method comprising: placing a Mn raw material in a magnesia crucible to perform melting with the use of a vacuum induction melting furnace (VIM furnace) at a melting temperature of 1240 to 1400° C. under an inert atmosphere of 500 Torr or less; then adding calcium in a range between 0.5 and 2.0% of the weight of Mn to perform deoxidation and desulfurization; casting the resultant in an iron mold after the completion of the deoxidation and desulfurization to manufacture an ingot; then placing the Mn ingot in a skull melting furnace; reducing pressure to 10 | 2016-02-04 |
20160032428 | Magnesium-Zinc-Manganese-Tin-Yttrium Alloy and Method for Making the Same - A magnesium alloy including about 2 percent by weight to about 8 percent by weight zinc, about 0.1 percent by weight to about 3 percent by weight manganese, about 1 percent by weight to about 6 percent by weight tin, about 0.1 percent by weight to about 4 percent by weight yttrium, and magnesium. | 2016-02-04 |
20160032429 | Low Silver, Low Nickel Brazing Material - A homogenous brazing material essentially consisting of relatively low amounts of silver and nickel together with copper, zinc, and other constituents is provided. The brazing material has a working temperature exceeding 630° F. and is preferably between about 1250° F. and 1500° F. The brazing material preferably has about 30 percent by weight of silver, about 36 percent by weight of copper, about 32 percent by weight of zinc, and about 2 percent by weight of nickel. The addition of nickel in the above-specified amount improves resistance against interface corrosion in aqueous solutions, aids in the strength of the alloy, and provides improved wettability on ferrous and non-ferrous substrates. The brazing material may also include a flux, such as a core or a coating. | 2016-02-04 |
20160032430 | DEVELOPMENT OF NANOSTRUCTURE AUSTEMPERED DUCTILE IRON WITH DUAL PHASE MICROSTRUCTURE - A method for forming an austempered iron composition with a nanoscale microstructure includes a step of heating an iron-carbon-silicon alloy with silicon to a first temperature that is lower than A1 for the iron-carbon-silicon alloy. The iron-carbon-silicon alloy is then adiabatically deformed such that the temperature of the iron-carbon-silicon alloy rises to a second temperature which is sufficient to form proeutectoid ferrite and austenite. The iron-carbon-silicon alloy is cooled to a first austempering temperature. The iron-carbon-silicon alloy is then heated to a second austempering temperature that is greater than the first austempering temperature to form a dual phase microstructure. Characteristically, the dual phase microstructure includes proeutectoid ferrite and ausferrite. | 2016-02-04 |
20160032431 | STEEL SHEET FOR NITRIDING AND PRODUCTION METHOD THEREFOR - A steel sheet for nitriding has excellent formability and punchability. The steel sheet has a composition including, in percent by mass, 0.02% to 0.08% of C, 0.1% or less of Si, 0.2% to 1.8% of Mn, 0.05% or less of P, 0.02% or less of S, 0.01% to 0.06% of Al, 0.5% to 1.5% of Cr, 0.01% or less of N, and the balance being Fe and incidental impurities; and has a microstructure including ferrite as a main phase and pearlite and/or bainite as a secondary phase. The ferrite has a fraction of 70% or more in the entire microstructure and an average grain diameter of 5 to 25 gm. An average length of the major axis of cementite present in the secondary phase in a cross section in the rolling direction of the steel sheet is 3.0 μm or less. | 2016-02-04 |
20160032432 | HIGH-PERFORMANCE LOW-ALLOY WEAR-RESISTANT STEEL AND METHOD OF MANUFACTURING THE SAME - A high-performance low-alloy wear-resistant steel sheet and a method of manufacturing the same, which has the chemical compositions (wt %): C: 0.21-0.32%; Si: 0.10-0.50%; Mn: 0.60-1.60%; B: 0.0005-0.0040%; Cr: less than or equal to 1.50%; Mo: less than or equal to 0.80%; Ni: less than or equal to 1.50%; Nb: less than or equal to 0.080%; V: less than or equal to 0.080%; Ti: less than or equal to 0.060%; Al: 0.010-0.080%, Ca: 0.0010-0.0080%, N: less than or equal to 0.0080%, O: less than or equal to 0.0080%, H: less than or equal to 0.0004%, P: less than or equal to 0.015%, S: less than or equal to 0.010%, and (Cr/5+Mn/6+50B): more than or equal to 0.20% and less than or equal to 0.55%; (Mo/3+Ni/5+2Nb): more than or equal to 0.02% and less than or equal to 0.45%; (Al+Ti): more than or equal to 0.01% and less than or equal to 0.13%, the remainders being Fe and unavoidable impurities. The wear-resistant steel sheet of the present invention obtained by the above-mentioned compositions and TMCP process, has high strength, high hardness, good toughness, excellent wear-resistant performance, and is applicable to wearing parts in various mechanical equipments. | 2016-02-04 |
20160032433 | STAINLESS STEEL ALLOYS, TURBOCHARGER TURBINE HOUSINGS FORMED FROM THE STAINLESS STEEL ALLOYS, AND METHODS FOR MANUFACTURING THE SAME - Disclosed is an austenitic stainless steel alloy that includes, by weight, about 22% to about 28% chromium, about 3.5% to about 6.5% nickel, about 1% to about 6% manganese, about 0.5% to about 2.5% silicon, about 0.3% to about 0.6% carbon, about 0.2% to about 0.8% niobium, about 0.2% to about 0.8% nitrogen, and a balance of iron. Molybdenum and tungsten are excluded. The alloy is suitable for use in turbocharger turbine housing applications for temperature up to about 980° C. | 2016-02-04 |
20160032434 | HEAT-RESISTANT AUSTENITIC STAINLESS STEEL SHEET - This heat-resistant austenitic stainless steel sheet contains, in mass %, C: 0.05 to 0.15%, Si: 1.0 to 3.5%, Mn: 0.5 to 2.0%, P: not more than 0.04%, S: not more than 0.01%, Cr: 23.0 to 26.0%, Ni: 10.0 to 15.0%, Mo: 0.50 to 1.20%, Ti: not more than 0.1%, Al: 0.01 to 0.10% and N: 0.10 to 0.30%, wherein the total amount of C and N (C+N) is from 0.25 to 0.35%, and the balance is composed of Fe and unavoidable impurities. The heat-resistant austenitic stainless steel can be used in a high-temperature environment that reaches a maximum temperature of 1,100° C. | 2016-02-04 |
20160032435 | ZIRCONIUM (ZR) AND HAFNIUM (HF) BASED BMG ALLOYS - The disclosure is directed to Zr and Hf bearing alloys that are capable of forming a metallic glass, and more particularly metallic glass rods with diameters at least 1 mm and as large as 5 mm or larger. The disclosure is further directed to Zr and Hf bearing alloys that demonstrate a favorable combination of glass forming ability, strength, toughness, bending ductility, and/or corrosion resistance. | 2016-02-04 |
20160032436 | PROCESS FOR MAKING FINISHED OR SEMI-FINISHED ARTICLES OF SILVER ALLOY - A process for making a finished or semi-finished article of silver alloy, said process comprising the steps of providing a silver alloy containing silver in an amount of at least 77 wt %, copper and an amount of germanium that is preferably at least 0.5 wt % and is effective to reduce tarnishing and/or firestain, making or processing the finished or semi-finished article of the alloy by heating at least to an annealing temperature, gradually cooling the article; and reheating the article to effect precipitation hardening thereof. The avoidance of quenching reduces the risk of damage to the article. | 2016-02-04 |
20160032437 | Nanostructured Titanium Alloy and Method for Thermomechanically Processing the Same - A nanostractured titanium alloy article is provided. The nanostractured alloy includes a developed titanium structure having at least 80% of grains of a grain size≦1.0 microns. | 2016-02-04 |
20160032438 | HIGH-STRENGTH PLATED STEEL PLATE FOR WELDED STRUCTURAL MEMBER, AND METHOD FOR PRODUCING THE SAME - A high-strength plated steel plate for a welded structural member having a steel composition containing from 0.050 to 0.150% of C, from 0.001 to 1.00% of Si, from 1.00 to 2.50% of Mn, from 0.005 to 0.050% of P, from 0.001 to 0.020% of S, and from 0.005 to 0.100% of Al, having a steel base material having a metal structure containing a ferrite phase and a second phase containing mainly martensite having an average crystal grain diameter of 8 mm or less, and having a chemical composition and a thickness t (mm) of the steel base material regulated to obtain a value, C/0.2+Si/5.0+Mn/1.3+Cr/1.0+Mo/1.2+0.4t−0.7(Cr+Mo) | 2016-02-04 |
20160032439 | METHOD FOR MANUFACTURING GALVANIZED STEEL SHEET FOR HOT STAMPING, HOT-DIP GALVANNEALED STEEL SHEET FOR HOT STAMPING AND METHOD FOR MANUFACTURING SAME, AND HOT STAMPED COMPONENT - Provided is a method for producing a plated steel sheet with high Si content for hot stamping, which is capable of suppressing the generation of unplated portions, while maintaining high bonding strength in a welded part in cases where a galvanized steel sheet containing a large amount of Si, namely, 0.7% or more of Si is used for hot stamping applications. In this production method, a hot-rolled pickled steel sheet or cold-rolled steel sheet containing 0.10-0.5% by mass of C, 0.7-2.5% by mass of Si, 1.0-3% by mass of Mn, and 0.01-0.5% by mass of Al is annealed in a reducing atmosphere and then plated, thereby producing a galvanized steel sheet for hot stamping. This method for producing a galvanized steel sheet for hot stamping is characterized in that the annealing is carried out within the range of 500 to 700° C. for 30 to 270 seconds. | 2016-02-04 |
20160032440 | PROCESS FOR FABRICATING AN AIRCRAFT PART COMPRISING A SUBSTRATE AND A SUBSTRATE COATING LAYER - A method of fabricating a part ( | 2016-02-04 |
20160032441 | APPARATUS FOR MANUFACTURING DISPLAY DEVICE AND METHOD OF MANUFACTURING DISPLAY DEVICE - An apparatus for manufacturing a display device and a method of manufacturing a display device is disclosed. In one aspect, the apparatus includes a guider configured to guide a substrate on which a display portion is formed, a plasma sprayer configured to be spaced apart from the display portion and configured to spray plasma onto the substrate and a mask configured to be arranged over the substrate and cover the display portion. The mask includes a body portion configured to face the display portion and a protrusion portion formed at an end of the body portion and configured to extend towards the substrate. | 2016-02-04 |
20160032442 | ENHANCED ACTIVATION OF SELF-PASSIVATING METALS - A workpiece made from a self passivating metal and having one or more surface regions defining a Beilby layer as a result of a previous metal shaping operation is activated for subsequent low temperature gas hardening by exposing the workpiece to the vapors produced by heating an oxygen-free nitrogen halide salt. | 2016-02-04 |
20160032443 | Vanadium oxide thermo-sensitive film material with high temperature coefficient of resistance and a preparing method thereof - A vanadium oxide thermo-sensitive film material with a high temperature coefficient of resistance (TCR) contains a rare earth element of Yttrium serving as a dopant in a preparation process. The vanadium oxide thermo-sensitive film material includes a substrate and a yttrium-doped vanadium oxide film layer. The yttrium-doped vanadium oxide film layer includes three elements of vanadium, oxygen and yttrium, wherein the atomic concentration of yttrium is at a range of 1%-8%, the atomic concentration of vanadium is at a range of 20-40% and the residue is oxygen. The method for preparing the vanadium oxide thermo-sensitive film material with high TCR includes a reactive magnetron sputtering method using a low-concentration yttrium-vanadium alloy target as a sputtering source or a reactive magnetron co-sputtering method using dual targets including a high-concentration yttrium-vanadium alloy target and a pure vanadium target as a co-sputtering source. | 2016-02-04 |
20160032444 | COATED CUTTING TOOL AND A METHOD OF PRODUCING A COATED CUTTING TOOL - The present disclosure relates to a coated cutting tool including a substrate and a coating disposed on the substrate, wherein the coating includes a layer of Ti | 2016-02-04 |
20160032445 | PLASMA PROCESSING APPARATUS AND PLASMA PROCESSING METHOD - A plasma processing apparatus includes a first electrode, a second electrode disposed to face the first electrode, a chamber, a first high-frequency power supply, a direct-current power supply, and a gas supply source. The plasma processing apparatus generates first plasma to form a film of a reaction product on the second electrode by causing the first high-frequency power supply to supply first high-frequency power to the second electrode and causing the gas supply source to supply a first gas into the chamber; and generates second plasma to sputter the film of the reaction product by causing the first high-frequency power supply to supply the first high-frequency power to the second electrode, causing the direct-current power supply to supply direct-current power to the second electrode, and causing the gas supply source to supply a second gas into the chamber. | 2016-02-04 |
20160032446 | FILM FORMING APPARATUS AND FILM FORMING METHOD - A film forming apparatus, for forming a metal oxide film on an object, includes a holding unit and a heating unit. The holding unit includes a first heater and holds the object in a processing chamber. A first heater power supply supplies power to the first heater. A target electrode is electrically connected to a metal target provided above the holding unit. A sputtering power supply is electrically connected to the target electrode. An introduction mechanism supplies an oxygen gas toward the holding unit. The heating unit includes a second heater for heating the object and a moving mechanism for moving the second heater between a region in a first space disposed above the holding unit and a region in a second space separated from the first space. A second heater power supply supplies power to the second heater. | 2016-02-04 |
20160032447 | NICKEL-CHROMIUM-SILICON BASED COATINGS - A method of depositing Ni—Cr and Si coatings onto a turbine component comprising supplying a Ni—Cr target and Si target with a dual-gun magnetron sputtering system; introducing inert gas and negatively biasing the magnet assembly; grounding or negatively biasing the turbine component to be coated; rotating the turbine component, wherein the turbine component has a surface; and forming a Ni—Cr and Si coating on the component surface. | 2016-02-04 |
20160032448 | SUPERHYDROPHOBIC COATING MATERIAL AND METHOD FOR MANUFACTURING THE SAME - The present disclosure relates to a superhydrophobic coating material and a method for manufacturing the superhydrophobic coating material. The superhydrophobic coating material according to the present disclosure includes a substrate provided with a three-dimensional nano structure; and a coating layer comprising a rare earth metal oxide formed on the three-dimensional nano structure. The method for manufacturing the superhydrophobic coating material according to the present disclosure includes preparing a substrate provided with a three-dimensional nano structure; and forming a coating layer comprising a rare earth metal oxide on the three-dimensional nano structure by supplying a precursor including a rare earth metal and an oxidant one by one onto the substrate, and the temperature of the substrate is controlled in the forming step so that an atomic ratio of a carbon element in the coating layer is less than 1% to form the coating layer with superhydrophobic property. | 2016-02-04 |
20160032449 | GYROSCOPE AND DEVICES WITH STRUCTURAL COMPONENTS COMPRISING HfO2-TiO2 MATERIAL - Disclosed are devices, materials, systems, and methods, including a device that includes one or more structural components, at least one of the one or more structural components comprising substantially HfO | 2016-02-04 |
20160032450 | METHOD FOR A DIAMOND VAPOR DEPOSITION - The present invention relates to a method for depositing nanocrystalline diamond using a diamond vapor deposition facility which includes: a vacuum reactor including a reaction chamber connected to a vacuum source; a plurality of plasma sources arranged along a matrix that is at least two-dimensional in the reaction chamber; and a substrate holder arranged in the reactor, said method being characterized in that the deposition is carried out at a temperature of 100 to 500° C. | 2016-02-04 |
20160032451 | REMOTE PLASMA CLEAN SOURCE FEED BETWEEN BACKING PLATE AND DIFFUSER - Embodiments of the present disclosure provide an apparatus having a remote plasma clean source in which the remote plasma clean source delivers radicals from the remotely generated plasma to the chamber at a location disposed between a backing plate and a diffuser. | 2016-02-04 |
20160032452 | Atomic Layer Deposition Method Using Source Precursor Transformed by Hydrogen Radical Exposure - A film of source precursor molecules injected onto a substrate are reacted with hydrogen radicals, such as those produced in a hydrogen plasma, prior to reaction with a reactant precursor. This replaces the functional groups of the reactant precursor (e.g., methyl groups in alkyl groups) with hydrogen, thus reducing the overall size of the source precursor molecule. An additional cycle of source precursor molecules are injected onto the substrate, some of which occupy portions of the substrate surface left unoccupied by the now absent methyl functional groups. This increases the density of source precursor molecules (i.e., reaction sites) on the substrate. The reactivity of the source precursor molecules exposed to hydrogen radicals (or an H | 2016-02-04 |
20160032453 | SYSTEMS AND METHODS FOR VAPOR DELIVERY - A vapor delivery system includes an ampoule to store liquid precursor and a heater to partially vaporize the liquid precursor. A first valve communicates with a push gas source and the ampoule. A second valve supplies vaporized precursor to a heated injection manifold. A valve manifold includes a first node in fluid communication with an outlet of the heated injection manifold, a third valve having an inlet in fluid communication with the first node and an outlet in fluid communication with vacuum, a fourth valve having an inlet in fluid communication with the first node and an outlet in fluid communication with a second node, a fifth valve having an outlet in fluid communication with the second node, and a sixth valve having an outlet in fluid communication with the second node. A gas distribution device is in fluid communication with the second node. | 2016-02-04 |