| 05th week of 2016 patent applcation highlights part 23 |
| Patent application number | Title | Published |
|---|
| 20160031752 | GLASS OR GLASS-CERAMIC FOR WINDOWS, COUNTERTOPS, AND OTHER APPLICATIONS - Equipment and manufacturing processes allow for strengthened glass or glass ceramic articles having unique stress profiles, such as high negative tensile stresses and steep tensile stress curves with respect to depth, in strengthened glass or glass ceramic articles that are thin and/or have large-area structures for a given degree of thermal temping. | 2016-02-04 |
| 20160031753 | THIN DICING GLASS ARTICLE - A strengthened glass sheet product along with a process and an apparatus for strengthening a glass sheet are provided. The process comprises cooling the glass sheet by non-contact thermal conduction for sufficiently long to fix a surface compression and central tension of the sheet. The process results in thermally strengthened glass sheets having improved breakage properties. | 2016-02-04 |
| 20160031754 | PROCESS FOR PRODUCING PHASE SEPARATION GLASS FILM, PROCESS FOR PRODUCING POROUS GLASS FILM, GLASS MEMBER, AND IMAGING DEVICE - A process for producing a phase separation glass film including a film formation step of forming a film including glass powder on both faces of a substrate, and a baking step of baking the film to form a phase separation glass film on both faces of the substrate simultaneously. The baking step is performed in a state in which the substrate is disposed such that an in-plane direction of the substrate is perpendicular to a gravitational direction by supporting the substrate at a portion where the film is not formed. In the baking step, a member having a thermal conductivity higher than that of the substrate is disposed below the substrate so as not to be in contact with the film. | 2016-02-04 |
| 20160031755 | METHOD FOR MODIFYING THE TRANSMISSION OF GLASSES AND GLASS CERAMICS AND GLASS OR GLASS CERAMIC ARTICLES THAT CAN BE PRODUCED ACCORDING TO THE METHOD - A product is provided that includes a volume-colored monolithic glass or glass ceramic element and to a method for producing same. The glass or glass ceramic element has a first region in which the coloration is modified so that light transmission of the first region differs from light transmission of a second, adjacent region. The light scattering in the region of modified coloration in the glass or glass ceramic remains the same as light scattering in the second, adjacent region with non-modified light transmission. | 2016-02-04 |
| 20160031756 | NOVEL PHOSPHORUS-DOPED SULFO-BELITIC CLINKER - A new phosphorus-doped sulfo-belite-based clinker, a method for preparing this clinker, as well as the use of the clinker for preparing a hydraulic binder and, later on, grout, concrete or mortar. | 2016-02-04 |
| 20160031757 | CARBONATABLE CALCIUM SILICATE COMPOSITIONS AND METHODS THEREOF - The invention provides novel carbonatable calcium silicate compositions and carbonatable calcium silicate phases that are made from widely available, low cost raw materials by a process suitable for large-scale production. The method of the invention is flexible in equipment and production requirements and is readily adaptable to manufacturing facilities of conventional cement. The invention offers an exceptional capability to permanently and safely sequesters CO | 2016-02-04 |
| 20160031758 | CEMENT ADDITIVES PRODUCED BY COMBUSTION OF COAL WITH CLAY AND SLAG - Coal is combusted in the presence of a clay additive and a slag additive to produce a combustion product that is useful as a pozzolanic additive for cement. The combustion process may be performed in a coal-fired boiler of an electrical power generation plant, resulting in improved operational efficiency and controlled emissions. | 2016-02-04 |
| 20160031759 | POLYCARBOXYLIC ACID POLYMER FOR BLENDING IN CEMENT - An object of the present invention is to provide a polycarboxylic acid polymer for blending in cement for a cement composition superior both in dispersion and dispersibility-retention. The object was achieved by providing the present invention of a polycarboxylic acid polymer for blending in cement, | 2016-02-04 |
| 20160031760 | USE OF COMPOUNDS CONTAINING ALUMINIUM OXIDE AND SILICON OXIDE FOR PRODUCING A HYDROPHILIC BUILDING PRODUCT - The use of a binder system comprising compounds containing aluminium oxide and silicon oxide for producing a hydrophilic building product, characterized in that the sum of the oxides calculated as Al | 2016-02-04 |
| 20160031761 | Surfactant Composition for Use in Gypsum Wallboard Manufacture - A gypsum composition including calcined gypsum, water, and a foaming agent composition which comprises at least one betaine, either alone or in combination with at least one alkyl sulfate and/or at least one alkyl ether sulfate, is disclosed. The gypsum composition can be used to prepare foamed gypsum wallboard. | 2016-02-04 |
| 20160031762 | SLURRIES FOR COMPOSITE MATERIALS - Slurry and tape compositions include particles of a precursor that converts to a ceramic material when heated to a firing temperature, at least one binder that is capable of adhering the particles of the ceramic precursor together to form a pliable prepreg tape, at least one liquid plasticizer, and at least one solvent in which the binder is dissolved. The solvent may be sufficiently volatile to evaporate from the slurry composition during formation of the tape, yet the tape may also be pliable as a result of the slurry composition containing a sufficient amount of the liquid plasticizer. | 2016-02-04 |
| 20160031763 | GROWTH SUPPLEMENT FOR EFFICIENT PRODUCTION OF AGRICULTURAL AND LIVESTOCK PRODUCTS - Provided is a growth supplement for efficient production of agricultural and livestock products, more specifically, a growth supplement for environment-friendly crop cultivation and livestock rearing to increase yields of crops and livestock, which is prepared by mixing specific amounts of antibiotic fruit juices, one or more sources of sugar, one or more sources of hydrogen carbonate, one or more sources of chloride ion and antifebrile vegetable juices depending on crops (species) and cultivation (livestock) conditions to feed the livestock or crops. The growth supplement is prepared by admixing and stirring antibiotic fruit juices in an amount of 2 to 10 parts by weight; the source of hydrogen carbonates in an amount of 1 to 4 parts by weight; the source of chloride ion in an amount of 1 to 4 parts by weight; and antifebrile vegetable juices in an amount of 2 to 8 parts by weight, based on 100 parts by the source of sugar. | 2016-02-04 |
| 20160031764 | USE OF ACYLATED CARBONIC ESTERS OF GLYCEROL IN AGRICULTURE - A process for treating plants, including the application of at least one compound, termed carbonic ester of glycerol, including at least one carboxylic ester function formed by a carbonic acid-derived group and at least one glycerol-derived group, with the exception of cyclic glyceryl carbonate including five ring members. | 2016-02-04 |
| 20160031765 | POLYURETHANE ENCAPSULATE - Embodiments relate to a polyurethane coating film that has improved water barrier properties combined with mechanical strength. According to embodiments, a polyurethane encapsulate includes a polyurethane film that is a reaction product of an aromatic isocyanate and a polyol, and the polyol includes a butylene oxide based polyether polyol in an amount of at least 35 wt % based on a total weight of the polyol. The polyurethane encapsulate further includes a particulate material that is enclosed by the polyurethane film. | 2016-02-04 |
| 20160031766 | CALCIUM-ALGINATE ENTRAPPED NANOSCALE ZERO-VALENT IRON (NZVI) - Nanoscale zero-valent iron (NZVI) particles or Ca-alginate-entrapped NZVI, are provided for use in environmental remediation, decontamination, and pollution control. When charged with a sorbed nutrient such as phosphate or selenium, they can be used as fertilizer. | 2016-02-04 |
| 20160031767 | PHOTOACTIVE ENERGETIC MATERIALS - Energetic materials that are photoactive or believed to be photoactive may include a conventional explosive (e.g. PETN, nitroglycerine) derivatized with an energetic UV-absorbing and/or VIS-absorbing chromophore such as 1,2,4,5-tetrazine or 1,3,5-triazine. Absorption of laser light having a suitably chosen wavelength may result in photodissociation, decomposition, and explosive release of energy. These materials may be used as ligands to form complexes. Coordination compounds include such complexes with counterions. Some having the formula M(L) | 2016-02-04 |
| 20160031768 | PYROTECHNIC COMPOSITION - The present invention relates to a pyrotechnic composition. | 2016-02-04 |
| 20160031769 | METHODS OF REDUCING IGNITION SENSITIVITY OF ENERGETIC MATERIALS, METHODS OF FORMING ENERGETIC MATERIALS HAVING REDUCED IGNITION SENSITIVITY, AND RELATED ENERGETIC MATERIALS - An energetic material comprising an elemental fuel, an oxidizer or other element, and a carbon nanofiller or carbon fiber rods, where the carbon nanofiller or carbon fiber rods are substantially homogeneously dispersed in the energetic material. Methods of tailoring the electrostatic discharge sensitivity of an energetic material are also disclosed. Energetic materials including the elemental fuel, the oxidizer or other element, and an additive are also disclosed, as are methods of reducing ignition sensitivity of the energetic material including the additive. The additive is combined with the elemental fuel and a metal oxide to form the energetic material. The energetic material is heated at a slow rate to render inert the energetic material to ignition while the energetic material remains ignitable when heated at a fast rate. | 2016-02-04 |
| 20160031770 | REACTOR WITH BAFFLE CONFIGURATION - A reactor includes a shell defining an interior, a plurality of baffles positioned in the interior of the reactor, and a fluid pathway defined between the plurality of baffles and extending between an inlet and an outlet. In some embodiments, the reactor has a degree of mixing of less than 0.2. | 2016-02-04 |
| 20160031771 | MFI Aluminosilicate Molecular Sieves and Methods for Using Same for Xylene Isomerization - MFI aluminosilicate molecular sieve catalysts are prepared from tetra-functional orthosilicates [e.g., Si(OR | 2016-02-04 |
| 20160031772 | Process for Recovering Paraxylene from at Least Two Feedstreams Containing Xylene Isomers - Processes for recovering paraxylene from at least two feedstreams containing xylene isomers. The process includes directing to a paraxylene recovery zone comprising at least one crystallization zone, a paraxylene-lean feedstream having a paraxylene to total xylene isomer ratio of 0.50 or less, and also directing to the paraxylene recovery zone, a paraxylene-rich feedstream having a paraxylene to total xylene isomer ratio of greater than 0.50. A paraxylene-containing product stream is recovered from the paraxylene recovery zone having a paraxylene to total xylene isomer ratio greater than that of the paraxylene-rich feedstream. The process provides improvements in paraxylene recovery efficiency and/or cost effectiveness. | 2016-02-04 |
| 20160031773 | COMPOSITION COMPRISING HF AND 1,3,3,3-TETRAFLUOROPROPENE - An azeotropic or quasi-azeotropic composition including hydrogen fluoride, 1,3,3,3-tetrafluoropropene and one or more (hydro)halogen-carbon compounds including between 1 and 3 carbon atoms. Also, a preferred azeotropic or quasi-azeotropic composition comprising hydrogen fluoride, 1,3,3,3-tetrafluoropropene, and one or more compounds selected from among 1,1,1,2,2-pentafluoropropane, 2,3,3,3-tetrafluoropropene, 3,3,3-trifluoropropene, 3,3,3-trifluoro-2-chloropropene, E-3,3,3-trifluoro-1-chloropropene, trifluoropropyne, 1,1,1,3,3-pentafluoropropane, 1,1,3,3-pentafluoropropane, 1,1,1,3,3-pentafluoropropene, 1,1,1,2,3-pentafluoropropene and 2-chloro, 1,1,1,2-tetrafluoropropane. | 2016-02-04 |
| 20160031774 | RANDOM RING PACKING FOR BIOMASS DIGESTER - A method comprises introducing cellulosic biomass solids to a digester comprising a reactor, gas feed line, biomass feed system, fluid circulation system including a fluid inlet, a pump, and an injector, a screen positioned within the reactor and defining a lower zone therebelow, and a bed of reactor packing material resting on the screen and defining thereby a packed zone; providing a liquid phase digestion medium containing a slurry catalyst in the digester, the catalyst being capable of activating molecular hydrogen; circulating the liquid phase digestion medium through the fluid circulation system; supplying an upwardly directed flow of molecular hydrogen through the cellulosic biomass solids; and maintaining the cellulosic biomass solids and slurry catalyst at a temperature sufficient to cause digestion of cellulosic biomass solids into an alcoholic component. | 2016-02-04 |
| 20160031775 | System And Method For Producing Neopentyl Glycol - The present invention describes a process for production of neopentyl glycol (NPG) from formaldehyde (FD) and isobutyraldehyde (IBD). FD and IBD first react to form hydroxypivaldehyde (HPD) in an aldol condensation step, then HPD is hydrogenated to form NPG in a hydrogenation step. The aldol condensation step is performed using a solid catalyst such as an ion exchange resin catalyst, which can be easily separated from the reaction product. The feed to the aldol condensation step is made homogeneous by adjusting the ratio of IBD, FD, and water in the feed or by adding a solvent that is miscible with both IBD and water. High purity NPG is recovered from the product of the hydrogenation step by a suitable method such as crystallization. | 2016-02-04 |
| 20160031776 | Preparation of Butanol from Ethanol Derived from Fermentation - In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc. | 2016-02-04 |
| 20160031777 | PROCESS FOR THE SELECTIVE PRODUCTION OF PROPANOLS BY HYDROGENATION OF GLYCEROL - The present invention discloses a process for the selective hydrogenation of glycerol in the liquid phase to produce 1- and 2-propanols in high yields as the major organic products. The process comprises subjecting a glycerol stream having at least 30% by weight water to a combination of low pressure and high temperature hydrogenation conditions in the presence of a promoted or un-promoted skeletal copper catalyst. | 2016-02-04 |
| 20160031778 | PROCESS AND SYSTEMS FOR OBTAINING 1,4-BUTANEDIOL FROM FERMENTATION BROTHS - A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol product. | 2016-02-04 |
| 20160031779 | PRODUCTION OF PROPYLENE GLYCOL MONOALKYL ETHER - Processes for producing propylene glycol monoalkyl ether are described herein and include contacting propylene oxide and an alcohol in the presence of an alkali or alkaline earth metal alkoxide catalyst to produce an alkoxylation mixture including propylene glycol monoalkyl ether; distilling the alkoxylation mixture to produce a first overhead stream including propylene oxide and the alcohol and a first bottoms stream including propylene glycol monoalkyl ether; distilling the first bottoms stream to produce a second overhead stream including purified propylene glycol monoalkyl ether and a second bottoms stream including heavier byproducts; further distilling the second bottoms stream to form a resulting bottoms stream including caustic and heavier byproducts; introducing an alkali metal borohydride into at least a portion of the resulting bottoms stream to form an alkali metal borohydride containing stream; and introducing the alkali metal borohydride containing stream into one or more distillations upstream of recovery of the second overhead stream. | 2016-02-04 |
| 20160031780 | ETHER BLENDS VIA REACTIVE DISTILLATION - A method for forming a blend of ethers from a blend of alcohols includes a step of reacting a hydrocarbon-containing gas with an oxygen-containing gas to form first product blend. The first product blend includes a blend of partially oxygenated compounds. The blend of partially oxygenated compounds is provided to a reactive distillation station where it is converted a second product blend. The second product blend typically includes a mixture of ethers. An apparatus implementing the method is also provided. | 2016-02-04 |
| 20160031781 | AGENT FOR IMPROVING TISSUE PENETRATION - The invention concerns a pharmaceutical preparation which improves penetration of active substances through the tissue membrane or barrier of the target organ. | 2016-02-04 |
| 20160031782 | CROSS-LINKED POLYMER ELECTROLYTE MEMBRANES AND CROSSLINKING MONOMER - Bifunctional styrenated crosslinkable monomers are produced by functionalizing a linear chain diol with styrene, the linear chain diol being a diol with linear chain fluorinated segments or a linear chain hydrocarbon diol. Crosslinked polymers are produced by polymerizing the styrene-based comonomer with the bifunctional styrenated crosslinkable monomers. Polymer electrolyte membranes are produced from the crosslinked polymers. Crosslinking a bifunctional fluorinated monomer with a sulfonic acid bearing comonomer produces crosslinked polymers and membranes there from with very high acid content and strong polymer structure. | 2016-02-04 |
| 20160031783 | PROCESS FOR PREPARING CYCLODODECANONE - Cyclododecanone (CDON) is prepared by epoxidizing cyclododecene (CDEN) to epoxycyclododecane (CDAN epoxide), and rearranging the CDAN epoxide to CDON to obtain a mixture comprising said CDON and cyclododecane (CDAN), wherein CDAN is separated from the CDON-containing mixture and oxidized to CDON. | 2016-02-04 |
| 20160031784 | PROCESS FOR PREPARING CYCLODODECANONE - Cyclododecanone (CDON) is prepared by epoxidizing cyclododecene (CDEN) to epoxycyclododecane (CDAN epoxide), and rearranging the CDAN epoxide to CDON to obtain a mixture comprising said CDON and CDEN, wherein CDEN is separated from the CDON-containing mixture and sent to the epoxidation to CDAN epoxide in step a. | 2016-02-04 |
| 20160031785 | THERMAL SALT-SPLITTING OF (ALKYL)AMMONIUM 3-HYDROXYPROPIONATE - A salt-splitting liquid (SSL) and a process that uses the SSL to “split” (alkyl)ammonium 3-hydroxypropionate salts into ammonia (or amines) and 3-hydroxypropionic acid (3-HP) that minimizes increases in viscosity and condensation reactions of the 3-HP. Converting (alkyl)ammonium 3-hydroxypropionate in an aqueous mixture to 3-HP includes admixing a polar aprotic organic solvent and an azeotroping solvent with the aqueous mixture. The azeotroping solvent forms an azeotrope mixture with water of the aqueous mixture. The SSL is heated to convert the (alkyl)ammonium 3-hydroxypropionate to 3-HP and ammonia, where heating produces a vapor phase containing at least water, ammonia and the azeotroping solvent. At least a portion of the water and the ammonia is removed from the vapor phase during the heating, and at least a portion of the azeotroping solvent is returned from the vapor phase back to SSL to maintain the azeotrope mixture with the water. | 2016-02-04 |
| 20160031786 | PROCESS FOR PREPARATION OF METHACRYLIC ACID AND METHACRYLIC ACID ESTERS - The invention relates to a process for preparation of at least one of methacrylic acid and a methacrylic acid ester, comprising the process stepsgas phase oxidation of at least one C | 2016-02-04 |
| 20160031787 | SYNTHESIS OF BIOBASED AND SUBSTITUTED TEREPHTHALIC ACIDS AND ISOPHTHALIC ACIDS - Methods for producing bio-terephthalic acid and bio-isophthalic acid. Methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and isophthalic acid from the bio-para-toluic acid and bio-meta-toluic acid. | 2016-02-04 |
| 20160031788 | METHOD OF MANUFACTURING DICARBOXYLIC ACIDS AND DERIVATIVES FROM COMPOSITIONS COMPRISING KETOCARBOXYLIC ACIDS - A crude composition comprising a ketocarboxylic acid such as levulinic acid, derived from biomass in an aqueous phase comprising impurities, can be efficiently converted in high yield to the corresponding dicarboxylic acid, such as succinic acid, which can be purified and dried. | 2016-02-04 |
| 20160031789 | PROCESS FOR PREPARING ACRYLIC ACID FROM METHANOL AND ACETIC ACID - A process for preparing acrylic acid from methanol and acetic acid, comprising (i) contacting a gaseous stream S0 comprising methanol, oxygen and inert gas with an oxidation catalyst to obtain a gaseous stream S1 comprising formaldehyde and inert gas; (ii) removing at least a portion of the inert gas present in S1 from at least a portion of the formaldehyde present in S1 by absorbing this formaldehyde in an absorbent to obtain a gaseous stream S2 comprising the portion of the inert gas removed, and to obtain a stream S3 comprising absorbent and absorbate comprising formaldehyde; (iii) optionally removing a portion or the entirety of the absorbent present in stream S3, such that a stream S3a remains from stream S3, and producing a stream S4 from at least stream S3 or stream S3a and a stream S5 comprising acetic acid; and (iv) contacting stream S4 in gaseous form with an aldol condensation catalyst to obtain a gaseous stream S6 comprising acrylic acid. | 2016-02-04 |
| 20160031790 | METHOD OF MANUFACTURE OF OCTANEDIOIC ACID, PRECURSORS, AND DERIVATIVES - A method for the manufacture of 1,8-octanedioic acid comprises: reacting gamma-valerolactone with an alcohol in the presence of an acid or a base catalyst to provide an alkyl pentenoate, converting the alkyl pentenoate in the presence of a metathesis initiator to provide the dialkyl octenedioate, reacting the dialkyl octenedioate with hydrogen in the presence of a hydrogenation catalyst to provide a dialkyl 1,8-octanedioate and hydrolyzing the dialkyl 1,8-octanedioate to provide the 1,8-octanedioic acid. | 2016-02-04 |
| 20160031791 | PROCESS FOR THE PRODUCTION OF ACETIC ACID AND DIMETHYL ETHER - A process for the production of acetic acid and dimethyl ether by contacting a mixture of methanol and methyl acetate with a zeolite catalyst wherein the zeolite has a 2-dimensional channel system comprising at least one channel having a 10-membered ring and having at least 5% of its cation exchange capacity occupied by one or more alkali metal cations. | 2016-02-04 |
| 20160031792 | RECOVERY OF 3-HYDROXYPROPIONIC ACID - A method for recovering a composition enriched in 3-hydroxypropionic acid from a fermentation broth comprising 3-hydroxypropionic acid and/or salts thereof comprises the steps of: (a) providing the fermentation broth having a pH of from about 2 to about 8 comprising: 3-hydroxypropionic acid and/or salts thereof, (b) acidifying the fermentation broth; (c) reducing the total sulfate ion and phosphate ion (d) distilling the resulting reduced ion aqueous solution and (e) recovering the product. | 2016-02-04 |
| 20160031793 | Purification Of Bio Based Acrylic Acid To Crude And Glacial Acrylic Acid - Processes for the purification of bio-based acrylic acid to crude and glacial acrylic acid are provided. The bio-based acrylic acid is produced from hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof. The purification includes some or all of the following processes: extraction, drying, distillation, and melt crystallization. The produced glacial or crude acrylic acid contains hydroxypropionic, hydroxypropionic acid derivatives, or mixtures thereof as an impurity. | 2016-02-04 |
| 20160031794 | ORGANIC OLIGOMERS OF ACYLGLYCEROL - Organic oligomers of acylglycerol having general formula (I): Formula (I), in which M1 and Q1 are organic groups; G11 is a hydroxylpropyl group; G12 and G13 are α/α′-acylglycerols; n is a natural integer from the range [0; 8]; m is a natural integer from the range [0; 4]; and p is a natural integer from the range [0; 3]. | 2016-02-04 |
| 20160031795 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES - This invention provides a compound having the structure | 2016-02-04 |
| 20160031796 | ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES - Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed. | 2016-02-04 |
| 20160031797 | ESTROGEN RECEPTOR LIGANDS AND METHODS OF USE THEREOF - The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBA compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including, inter alia, prevention and treatment of hormone-related diseases, cancers, inflammation, osteoporosis, peripheral vascular disease, reducing circulating lipid levels, and cardiovascular disease. | 2016-02-04 |
| 20160031798 | 2-AMINO-3-METHYL-HEX-5-ENOIC ACID AND ITS USE IN THE PRODCTION OF PEPTIDES SUCH AS BACITRACINS - The present invention concerns 2-amino-3-mmethyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it. | 2016-02-04 |
| 20160031799 | P62-ZZ CHEMICAL INHIBITOR - A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ inhibitor compound. | 2016-02-04 |
| 20160031800 | SYNTHESIS OF CHIRAL KYNURENINE COMPOUNDS AND INTERMEDIATES - Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine. | 2016-02-04 |
| 20160031801 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES - This invention relates to novel 2-amino-3-hydroxypropanoic acid derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an NMDA glycine-site antagonist. | 2016-02-04 |
| 20160031802 | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS - The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. | 2016-02-04 |
| 20160031803 | OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS - The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided. | 2016-02-04 |
| 20160031804 | Augmenting Moieties for Anti-Inflammatory Compounds - Augmented or synergized anti-inflammatory constructs are disclosed including terpenes covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids, amino acids and polyamines; and anti-inflammatory molecules covalently conjugated with specific amino acids. For the latter, further conjugation with a choline bioisostere further augments the anti-inflammatory activity. | 2016-02-04 |
| 20160031805 | CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE - The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R | 2016-02-04 |
| 20160031806 | SYNTHESIS OF TETRABUTYLAMMONIUM BIS(FLUOROSULFONYL)IMIDE AND RELATED SALTS - The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl fluoride solution to form the anion of bis(fluorosulfonyl)amine under conditions well suited for large-scale production. The bis(fluorosulfonyl)amine so produced can be isolated by methods described in the prior art, or isolated as an organic ion pair, such as an alkylammonium solid salt, or as an ionic liquid. | 2016-02-04 |
| 20160031807 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX - The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. | 2016-02-04 |
| 20160031808 | PROCESSES FOR THE PREPARATION OF (S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHANESULFONYLETHYLAMINE - Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine. | 2016-02-04 |
| 20160031809 | SUGAR ESTER PERACID ON SITE GENERATOR AND FORMULATOR - Methods and systems for on-site generation of peracid chemistry, namely peroxycarboxylic acids and peroxycarboxylic acid forming compositions, are disclosed. In particular, an adjustable biocide formulator or generator system is designed for on-site generation of peroxycarboxylic acids and peroxycarboxylic acid forming compositions from sugar esters. Methods of using the in situ generated peroxycarboxylic acids and peroxycarboxylic acid forming compositions are also disclosed. | 2016-02-04 |
| 20160031810 | BENZIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING BENZIDINE DERIVATIVE FOR TREATING LIVER DISEASE CAUSED BY HEPATITIS C VIRUS - The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus. | 2016-02-04 |
| 20160031811 | LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS - Disclosed herein are compounds of formula (I) | 2016-02-04 |
| 20160031812 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN - Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and prodrugs and pharmaceutically acceptable salts thereof. The Also featured are pharmaceutical compositions of the compounds and uses of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, and neuropathic pain). | 2016-02-04 |
| 20160031813 | Nampt Inhibitors - Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. | 2016-02-04 |
| 20160031814 | MODULATION OF K2P CHANNELS - Disclosed herein inter alia are compositions and methods useful in the treatment of diseases, for example pain, neurodegeneration, or mood disorders, and for modulating the activity of a K | 2016-02-04 |
| 20160031815 | NEW ARYLAMINOALCOHOL DERIVATIVES WITH ANTIPLASMODIAL ACTIVITY - The present invention relates to new arylaminoalcohol derivatives of formula (I), and to a method for the preparation of such compounds: I The invention also relates to the use of these compounds as medicaments, and in particular for the prevention and/or the treatment of parasitic diseases caused by apicomplexan parasites such as malaria and toxoplasmosis. Finally, the invention relates to pharmaceutical compositions containing such compounds of formula (I) as active principles. | 2016-02-04 |
| 20160031816 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS - The present invention provides compounds of Formula (I): | 2016-02-04 |
| 20160031817 | 3-PIPERIDONE COMPOUNDS AND THEIR USE AS NEUROKININ-1 (NK1) RECEPTOR ANTAGONISTS - The invention relates to 3-piperidone compounds, and in particular, to (2S)-phenyl-3-piperidone and its synthesis method. Use of the thus-synthesized 3-piperidone compounds as potent neurokinin-1 (NK1) receptor antagonists is also provided. | 2016-02-04 |
| 20160031818 | Metabolites of N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide - The invention relates to metabolites of cabozantinib (I) as well as uses thereof. | 2016-02-04 |
| 20160031819 | BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF - Novel base addition salts of nitroxoline with improved solubility and increased urine secretion under physiological conditions are described. Pharmaceutical compositions and methods of treatment using the pharmaceutical compositions are also described. | 2016-02-04 |
| 20160031820 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 2016-02-04 |
| 20160031821 | SDP-Containing Heterobifunctional Agents - The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R | 2016-02-04 |
| 20160031822 | 3'-[(2Z)-[1-(3,4-DIMETHYLPHENYL)-1,5-DIHYDRO-3-METHYL-5-OXO-4H-PYRAZOL-4-Y- LIDENE]HYDRAZINO]-2'-HYDROXY-[1,1'-BIPHENYL]-3-CARBOXYLIC ACID BIS-(MONOETHANOLAMINE) - Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same. | 2016-02-04 |
| 20160031823 | HDAC INHIBITORS - Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I). | 2016-02-04 |
| 20160031824 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF - The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof. | 2016-02-04 |
| 20160031825 | SUBSTITUTED DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted dihydropyrimidinones of formula 1 | 2016-02-04 |
| 20160031826 | Substituted Heterocyclic Compounds for Treating or Preventing Viral Infections - Disclosed herein are pyrimidine compounds of formula I and formula II and methods for treating or preventing a viral infection, such as infections caused by dengue virus in a subject, comprising administering to said subject an effective amount of a pyrimidine compound of formula I or formula II. | 2016-02-04 |
| 20160031827 | NOVEL FORM OF PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE - It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia. | 2016-02-04 |
| 20160031828 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals. | 2016-02-04 |
| 20160031829 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted bicyclic dihydropyrimidinones of formula 1 | 2016-02-04 |
| 20160031830 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted dihydropyrimidinones of formula 1 | 2016-02-04 |
| 20160031831 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted bicyclic dihydropyrimidinones of formula 1 | 2016-02-04 |
| 20160031832 | QUINAZOLINONE ANTIBIOTICS - A new class of antibiotics effective against methicillin-resistant | 2016-02-04 |
| 20160031833 | MICROCRYSTALLINE DIKETOPIPERAZINE COMPOSITIONS AND METHODS - Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles. The microcrystals can be dispersed by atomization and re-formed by spray drying into particles having spherical shell morphology. Active agents and excipients can be incorporated into the particles by spray drying a solution containing the components to be incorporated into microcrystalline diketopiperazine particles. In particular, the microcrystalline particle compositions are suitable for pulmonary drug delivery of one or more peptides, proteins, nucleic acids and/or small organic molecules. | 2016-02-04 |
| 20160031834 | METHOD FOR PRODUCING TDI-TRIMERISATES WITH HIGH PURITY - The invention relates to a novel method for producing polyisocyanurates comprising isocyanate groups, based on 2,4- and 2,6-toluylene diisocyanate (TDI) and to the use thereof in coating compositions. | 2016-02-04 |
| 20160031835 | TUBULIN INHIBITORS - Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V). | 2016-02-04 |
| 20160031836 | BIOMARKER - The invention is directed, in part, to selective cancer treatment regimes based on assaying for the presence or absence of a mutation in a nucleic acid that encodes MLL1 or for the presence of reduced levels of MLL1. | 2016-02-04 |
| 20160031837 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF - The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute. | 2016-02-04 |
| 20160031838 | SMYD2 INHIBITORS - The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase. | 2016-02-04 |
| 20160031839 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. | 2016-02-04 |
| 20160031840 | 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds - The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use. | 2016-02-04 |
| 20160031841 | 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS - Provided herein are 2,5-disubstituted arylsulfonamide CCR3 antagonists, e.g., compounds of Formula I, and pharmaceutical compositions thereof: Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition. | 2016-02-04 |
| 20160031842 | SYNTHESIS OF ISOHEXIDE DICARBAMATES AND DERIVATIVES THEREOF - Dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a non-aqueous solvent, with a miscible acid having a pKa of about 3.7 or less. The dicarbamates of HMF-reduction products can serve as precursor materials from which various derivative compounds can be synthesized. | 2016-02-04 |
| 20160031843 | SYNTHESIS OF NOVEL IONIC LIQUIDS FROM LIGNIN-DERIVED COMPOUNDS - Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid. | 2016-02-04 |
| 20160031845 | IN-SITU GENERATION OF RUTHENIUM CATALYSTS FOR OLEFIN METATHESIS - The present invention relates to a process for preparing olefins by means of metathesis, which comprises the following steps
| 2016-02-04 |
| 20160031846 | KETAL ADDUCTS, METHODS OF MANUFACTURE, AND USES THEREOF - A ketal amide has a structure represented by formula (I): | 2016-02-04 |
| 20160031847 | GUANIDINOBENZOIC ACID ESTER COMPOUND - [Problem]To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. | 2016-02-04 |
| 20160031848 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE - 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-•dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction. | 2016-02-04 |
| 20160031849 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE - 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by coupling 3-bromopyridine with commercially available 3-aminopyrazole, purifying the 3-(3-amino-1H-pyrazol-1-yl)pyridine by crystallization, and converting the amino group to a chloro group by a Sandmeyer reaction. | 2016-02-04 |
| 20160031850 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE - 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with acrylonitrile to provide 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine, by oxidizing to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction. | 2016-02-04 |
| 20160031851 | NOVEL TRIAZOLINTHIONE DERIVATIVES - The present invention relates to novel triazolinthione derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. | 2016-02-04 |
| 20160031852 | VMAT INHIBITORY COMPOUNDS - Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions. | 2016-02-04 |
