| 05th week of 2010 patent applcation highlights part 48 |
| Patent application number | Title | Published |
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| 20100028794 | AQUEOUS DISPERSION OF FINE RESIN PARTICLES, METHOD FOR PRODUCING AQUEOUS DISPERSION OF FINE RESIN PARTICLES, AND METHOD FOR PRODUCING TONER PARTICLES - The present invention provides an aqueous dispersion of nonspherical fine resin particles having excellent storage stability and processability such as aggregation and adherence to other substances, a method for producing the aqueous dispersion of fine resin particles, and a method for producing toner particles using the aqueous dispersion of fine resin particles. The present invention relates to an aqueous dispersion of fine resin particles characterized in that the fine resin particles are nonspherical particles with an average minor axis being 0.02 μm or more and 1.00 μm or less and an average ratio of a major axis to a minor axis being 2.0 or more and 5.0 or less, a method for producing the aqueous dispersion of fine resin particles, and a method for producing toner particles using the aqueous dispersion of fine resin particles. | 2010-02-04 |
| 20100028795 | TONER - In a toner containing at least a binder resin, a colorant, an ester compound and a low-melting material, the ester compound is an ester of dipentaerythritol with a carboxylic acid having 18 or more to 25 or less carbon atoms, and, where the melting point of the ester compound is represented by Tm | 2010-02-04 |
| 20100028796 | MAGNETIC CARRIER AND TWO-COMPONENT DEVELOPER - A magnetic carrier and two-component developer are provided alleviating coarse images, fogging when printing is done after a copier body is left standing for one week in a high temperature and high humidity environment and carrier adhesion after extensive operation in a low image ratio. The magnetic carrier includes magnetic carrier particles including porous magnetic core particles and a resin, wherein in a mercury intrusion method applied to the porous magnetic core particles, a pore diameter in which a differential pore volume in the specific pore diameter range becomes maximum is in a specific range, and when the maximum value of a differential pore volume in the specific pore diameter range is defined as P1 and the maximum value of a differential pore volume in the specific pore diameter range is defined as P2, P1 is in a specific range and the ratio P2/P1 is in a specific range. | 2010-02-04 |
| 20100028797 | FUSER MEMBER COATING HAVING ALIPHATIC-AROMATIC FLUOROPOLYMERS - A fuser member including a substrate, and thereover, an outer layer with a fluorinated polymer having a flexible aliphatic segment and a rigid aromatic segment, wherein the aliphatic segment and the aromatic segment are bonded through a linkage group. | 2010-02-04 |
| 20100028798 | TONER FOR ELECTROSTATIC LATENT IMAGE DEVELOPMENT AND IMAGE FORMING METHOD - A toner for electrostatic latent image development, in which the image quality is fine, toner blister would not occur, and furthermore, the image quality which can fulfill customer's satisfaction can be obtained regardless of the temperature humidity environment in the image forming. The toner for electrostatic latent image development is made by agglomeration of resin particles and colorant particles in an aqueous medium. The acid value of the toner is less than 20 mgKOH/g, and the hydroxyl value of the toner is 7 to 57 mgKOH/g. | 2010-02-04 |
| 20100028799 | RESIST COMPOSITION FOR IMMERSION EXPOSURE AND METHOD FOR RESIST PATTERN FORMATION - A resist composition for immersion exposure including a resin component (A) that exhibits changed alkali solubility under the action of acid, wherein the resin component (A) includes a polymer compound (A1) containing a structural unit (a0) having an acid-generating group that generates acid upon irradiation. | 2010-02-04 |
| 20100028800 | RADIATION-SENSITIVE RESIN COMPOSITION - It is intended to provide a radiation-sensitive resin composition, which comprises a radiation-sensitive acid generator excellent in resolution performance, heat stability, and storage stability, suppresses fluctuations in line width and deterioration in pattern profile attributed to standing waves, and produces a resist pattern improved in nano edge roughness and LEF. The radiation-sensitive resin composition is characterized by (A) a radiation-sensitive acid generator comprising: a sulfonium salt compound typified by 2,4,6-trimethylphenyldiphenylsulfonium 2,4-difluorobenzenesulfonate, 2,4,6-trimethylphenyldiphenylsulfonium 4-trifluoromethylbenzenesulfonate, or the like; and a sulfonimide compound. It is preferred that the composition should further comprise (B) a resin typified by a 4-hydroxystyrene/4-t-butoxystyrene copolymer, a 4-hydroxystyrene/t-butyl (meth)acrylate, or the like. | 2010-02-04 |
| 20100028801 | LITHOGRAPHY FOR PITCH REDUCTION - In one embodiment, a photoresist is lithographically patterned to form an array of patterned photoresist portions having a pitch near twice a minimum feature size. Fluorine-containing polymer spacers are formed on sidewalls of the patterned photoresist portions. The pattern of the fluorine-containing polymer spacers is transferred into an underlying layer to form a pattern having a sublithographic pitch. In another embodiment, a first pattern in a first photoresist is transferred into a first ARC layer underneath to form first ARC portions. A planarizing second optically dense layer, a second ARC layer, and a second photoresist are applied over the first ARC portions. A second pattern in the second photoresist is transferred into the second ARC layer to form second ARC portions. The combination of the first ARC portions and second ARC portions function as an etch mask to pattern an underlying layer with a composite pattern having a sublithographic pitch. | 2010-02-04 |
| 20100028802 | METHOD FOR RESIST UNDER LAYER FILM FORMATION, COMPOSITION FOR RESIST UNDER LAYER FILM FOR USE IN THE METHOD, AND METHOD FOR PATTERN FORMATION - This invention provides a method for resist under layer film formation, which can form a resist under layer film which can function as an anti-reflection film, is excellent in pattern transfer properties and etching resistance, and does not cause bending of a pattern even in the transfer of a fined pattern, and a composition for the resist under layer film for use in the method, and a method for pattern formation. The method for resist under layer film formation comprises the steps of coating a composition for resist under layer film formation (for example, a composition comprising a compound having a phenolic hydroxyl group, a solvent, and an accelerator) onto a substrate to be processed, and treating the formed coating film under an oxidizing atmosphere having an oxygen concentration of not less than 1% by volume and a temperature of 300° C. or higher to form a resist under layer film. | 2010-02-04 |
| 20100028803 | SURFACE TREATING AGENT FOR RESIST PATTERN FORMATION, RESIST COMPOSITION, METHOD OF TREATING SURFACE OF RESIST PATTERN THEREWITH AND METHOD OF FORMING RESIST PATTERN - A surface treating agent for resist pattern formation comprises a compound having two or more nucleophilic functional groups in each of the molecules thereof, or its salt, and a solvent. | 2010-02-04 |
| 20100028804 | RESIST COMPOSITION AND METHOD OF FORMING PATTERN THEREWITH - A resist composition comprises two or more polymers containing a first polymer and a second polymer and a compound that when exposed to actinic rays or radiation, generates an acid, wherein when the resist composition is formed into a dry resist film, the mixing ratios of at least the first and second polymers in the resist film exhibit a gradient distribution such that the mixing ratios continuously change in entirety or partially in the direction of the depth from the surface of the resist film on the air side toward a support, and wherein the mixing ratio of the first polymer at a superior portion of the resist film is higher than that of the second polymer, while the mixing ratio of the second polymer at an inferior portion of the resist film is higher than that of the first polymer. | 2010-02-04 |
| 20100028805 | POSITIVE PHOTOSENSITIVE RESIN COMPOSITION - It is an object of the present invention to provide a positive photosensitive resin composition capable of easily forming an image having high water repellency and high oil repellency on a surface of a cured film thereof even after a treatment with oxygen plasma or the like, and also having an insulating property with high precision and high throughput; and a cured film suitable for a film material of various displays obtained using the positive photosensitive resin composition. | 2010-02-04 |
| 20100028806 | METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATES - A negative-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution having a pH of from about 3 to 11. The precursor has a primary polymeric binder that comprises recurring units derived from one or more N-alkoxymethyl(meth)acrylamides, provided that such recurring units are present in the primary polymeric binder in an amount of at least 10% based on the total dry primary polymeric binder weight. In addition, the primary polymeric binder is present in an amount of from about 12 to about 70% based on total imageable layer dry weight. The imaged precursor can be processed off-press or on-press. | 2010-02-04 |
| 20100028807 | Imide Compound and Chemically Amplified Resist Composition Containing The Same - An imide compound represented by the formula (I): | 2010-02-04 |
| 20100028808 | PHOTOSENSITIVE ELEMENT - A photosensitive element wherein the haze of the support film | 2010-02-04 |
| 20100028809 | DOUBLE PATTERNING FOR LITHOGRAPHY TO INCREASE FEATURE SPATIAL DENSITY - A method of forming a pattern in at least one device layer in or on a substrate comprises: coating the device layer with a first photoresist layer; exposing the first photoresist using a first mask; developing the first photoresist layer to form a first pattern on the substrate; coating the substrate with a protection layer; treating the protection layer to cause a change therein where it is in contact with the first photoresist, to render the changed protection layer substantially immune to a subsequent exposure and/or developing step; coating the substrate with a second photoresist layer; exposing the second photoresist layer using a second mask; and developing the second photoresist layer to form a second pattern on the substrate without significantly affecting the first pattern in the first photoresist layer, wherein the first and second patterns together define interspersed features having a spartial frequency greater than that of the features defined in each of the first and second patterns separately. The process has particular utility in defining source, drain and fin features of finFET devices with a smaller feature size than otherwise achievable with the prevailing lithography tools. | 2010-02-04 |
| 20100028810 | ETCHING METHOD FOR USE IN DEEP-ULTRAVIOLET LITHOGRAPHY - In a lithography process using an ultraviolet process, the applied ultraviolet resist can be removed by intentionally condensing the ultraviolet resist before removing the ultraviolet resist. | 2010-02-04 |
| 20100028811 | METHODS OF MAKING COMPOSITE ELECTRODES - A method of making a component for use in a touch sensor includes modifying a substrate having disposed on it a plurality of electrically isolated conductors. Subsets of the conductors are electrically coupled to form composite electrodes. The component can be used as a set of electrodes in a customized touch sensor. | 2010-02-04 |
| 20100028812 | METHOD OF MANUFACTURING INKJET PRINTHEAD - Disclosed is a method of manufacturing an inkjet printhead. The method includes: forming a chamber layer comprising a plurality of ink chambers on a substrate; forming a sacrificial layer comprising water soluble polymer on the chamber layer so as to fill the ink chambers; forming a nozzle layer comprising a plurality of nozzles on the sacrificial layer and the chamber layer; forming an ink feed hole for ink supply in the substrate; and removing the sacrificial layer. The sacrificial layer and the chamber layer may be planarized using a chemical mechanical polishing (CMP) process. The CMP process may utilize a hard polishing, in which an oil based slurry along with polishing pad of hard material to reduce the occurrences of dishing phenomenon. | 2010-02-04 |
| 20100028813 | BACKSIDE CLEANING OF SUBSTRATE - A pellicle cover, system, and method for cleaning a photomask are disclosed. A pellicle cover is disposed over a photomask and pellicle without damaging the markings surrounding the mask pattern area. The pellicle cover can be practicably implemented in an improved photomask cleaning system and process in which the backside of the photomask may be cleaned without removing the pellicle from the patterned surface. | 2010-02-04 |
| 20100028814 | MANUFACTURING CROSS-STRUCTURES OF NANOSTRUCTURES - Techniques for manufacturing cross-structures of nanostructures, such as nanowires and carbon nanotubes are provided. In one embodiment, a method for manufacturing cross-structures of nanostructures include providing a substrate, patterning a first mask layer on the substrate, adsorbing first nanostructures onto surface regions of the substrate where the first mask layer does not exist, removing the first mask layer from the substrate, patterning a second mask layer on the substrate to which the first nanostructures are adsorbed, and adsorbing second nanostructures onto the surface regions of the substrate where the second mask layer does not exist, under conditions effective to manufacture cross-structures of nanostructures on the substrate. | 2010-02-04 |
| 20100028815 | SYSTEM AND METHOD EMPLOYING SECONDARY BACK EXPOSURE OF FLEXOGRAPHIC PLATE - A method of making a relief image on a flexographic print plate including imagewise exposing a mask including an imageable material disposed on a mask substrate to form an imaged mask having a mask image in the imageable material disposed on the mask substrate, the mask image including mask image areas each having a highlight value. The method further includes laminating the imaged mask to a front surface of a flexographic printing plate precursor, and exposing selected areas of the flexographic printing plate precursor to an imagewise addressable curing radiation via a back surface of the flexographic printing plate precursor based on the highlight values of corresponding mask image areas of the mask image. | 2010-02-04 |
| 20100028816 | PROCESS FOR PREPARING A POLYMERIC RELIEF STRUCTURE - The invention relates to a process for the preparation of a polymeric relief structure comprising the steps of coating a substrate with a coating composition comprising one or more radiation-sensitive ingredients, locally treating the coated substrate with electromagnetic radiation having a periodic or random radiation-intensity pattern, forming a latent image, and polymerizing and/or crosslinking the resulting coated substrate, wherein the coating composition comprises one or more radical scavengers in an amount sufficient to inhibit/retard substantial polymerization in the non-treated areas of the coated substrate, and low enough to allow polymerization and/or crosslinking in the treated areas in step c, with the proviso that the amount of oxygen present in the coating composition is not equal to the equilibrium amount of oxygen present when the coating composition is in contact with air. | 2010-02-04 |
| 20100028817 | Solution for treatment of resist substrate after development processing and method for treatment of resist substrate using the same - The present invention provides a resist substrate-treating solution for improving defects on a developed pattern surface, and also provides a resist substrate treatment method employing the treating solution. The resist substrate-treating solution comprises a solvent and a nitrogen-containing or oxygen-containing water-soluble polymer such as a polyamine, a polyol or a polyether. In the treatment method, a developed resist pattern is treated with the resist substrate-treating solution and then washed with pure water. | 2010-02-04 |
| 20100028818 | Process and apparatus for burning coal instead of oil - The present invention provides a process for burning coal instead of oil comprising the stages of coal gasification, gas combustion and optionally gas purification, utilization of residual heat of flue gas and flue gas discharge. The present invention further provides an apparatus for burning coal instead of oil. By present invention, the fuel cost for an oil-burning apparatus can be reduced by about four-fifths, so the resources of oil and natural gas can be saved either. Furthermore, the present invention has the advantages such as good reliability, high heat efficiency, high level of automation, high return on investment and good environmental benefits. | 2010-02-04 |
| 20100028819 | Combustion gas analysis - A chemical analysis method for determining the concentration of carbon monoxide, gaseous water and gaseous hydrocarbon in a combustion gas. The method includes the following steps: (a) directing wavelength modulated light from a single tunable diode laser at a wavelength in the range of from 2 to 2.5 micrometers through the combustion gas to a light detector to produce an absorption profile of the combustion gas (b) digitizing the adsorption profile of the combustion gas; (c) storing the digitized adsorption profile in a digital computer; (d) processing the digitized adsorption profile in the digital computer to produce an output from the computer indicative of the concentration of carbon monoxide, gaseous water and gaseous hydrocarbon in the combustion gas. | 2010-02-04 |
| 20100028820 | Candle Comprising a Wick, a Fuel and a Candle Dish - The invention relates to a candle comprising a wick, a fuel and a candle dish and also to a candle dish to be used in candles. The invention further relates to a fastening device comprising a candle comprising a candle dish and fastening material. | 2010-02-04 |
| 20100028821 | Fine dust removal system for lime kiln - A fine dust removal system for a rotary lime kiln includes a preheater adjacent the charging end of the kiln and a housing adjacent to and communicating with kiln charging end, such that a major portion of not off-gases containing solid particulates are diverted to the preheater and a minor portion thereof directed into the housing. At least a portion of the solid particulates is separated from the hot off-gases in the housing, while the hot off-gases leaving the housing, after solid particulate removal, are directed into the preheater. | 2010-02-04 |
| 20100028822 | SEAL HARDENING FURNACE OF LIQUID CRYSTAL DISPLAY DEVICE HAVING RACK BAR - A seal hardening furnace is presented in which seal lines in a liquid crystal display panel are hardened. The seal hardening furnace includes a cassette having a rack bar structure. The rack bar structure has rack bars for supporting the substrate along one direction and rack bar supports at ends of the rack bars that support the rack bars. The rack bars have air discharge openings therein. An air injecting passage is connected to the rack bar supports. An air supply unit supplies air through the air injecting passage and through the discharge openings to support the substrate thereon. | 2010-02-04 |
| 20100028823 | Anti-microbial orthodontic compositions and appliances and methods of production and use thereof - The presently disclosed and claimed invention is directed to anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions comprising an effective amount of a selenium compound, kits containing same, and methods of producing and using said anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions. | 2010-02-04 |
| 20100028824 | METHODS AND APPARATUS FOR DETERMINING AND OPTIMIZING EFFECTIVENESS OF EXO-SHELL DENTAL ALIGNMENT APPLIANCE - A method and apparatus for aligning the dento-facial region of a human. In one embodiment the method comprises providing an alignment appliance containing one or more optical elements; causing or instructing a human to cause the optical elements of the alignment device to come into contact with the dento-facial region, measuring or instructing the human to measure data regarding one or more characteristics of optical elements of the alignment appliance; modifying or causing to modify the alignment appliance to come into contact with the dento-facial region at different areas or by applying different forces to align the one or more teeth and repeating or causing to repeat one or more of steps of the method to align the dento-facial region of a human. | 2010-02-04 |
| 20100028825 | Method and System of Determining and Applying Orthodontic Forces Dependent on Bone Density Measurements - Orthodontic forces dependent on bone density measurements are determined by measuring bone density data in a scan of at least a portion of the teeth and jaw to produce a visual map of bone density is a selected area of the jaw. A two or three dimensional image of at least a portion of the jaw and teeth in the selected area of the jaw is generated. The bone density image is mapped into the two or three dimensional image. The attachment points on selected teeth, selected positions in the jaw, and/or selected orthodontic appliances to be connected to the teeth or jaw is determined. A force to be applied to the determined attachment points to move at least one tooth a predetermined distance and direction in the jaw taking into account the bone density through which the at least one tooth must move is calculated. | 2010-02-04 |
| 20100028826 | Manufacturing Method Of A Guiding Template For Dental Implantology, Guiding Template Manufactured Thereby and Reference Device For The Execution Of Such Method - The present invention relates to a method for making a guiding template for dental implantation. The method provides for associating a base template to a reference device, subjecting the patient to CAT, loading the data to a computer program, making an implant planning, generating the volume model, coupling the volume model to the reference device model, projecting the elements of the implant planning on the volume model, making a volume suitably drilled on the basis of the projection, coupling the volume to the reference device and making the holes of the planning on the base template. The present invention also relates to the guiding template thus obtained and the reference device for carrying out the method. | 2010-02-04 |
| 20100028827 | SYSTEM AND ARRANGEMENT FOR PRODUCTION AND INSERTION OF A DENTAL BRIDGE STRUCTURE - A system comprises a computer appliance designed to receive, and to present on screen, first information transmitted from identification equipment and based on detection of a jaw bone structure. Modification information which can be introduced into the computer appliance shows a visual dental bridge structure applied on the jaw bone structure with associated teeth and dentine. Orientations for implants are also shown. The computer appliance produces a CAD file which is based on the first information and the modification information. The file is received in a stereolithography machine which issues second information which can be processed in the equipment for production of the physical template which includes through-bores for sleeves which define implant orientation. A working model is produced with the aid of the physical template. The invention also relates to an arrangement of a template produced by stereolithography and by means of information from the computer appliance. | 2010-02-04 |
| 20100028828 | PROCEDURE SPECIFIC STORAGE BLOCK FOR HOLDING IMPLANT CONTAINERS AND SURGICAL TOOLS - A storage device is provided for holding bone implant surgery articles. The storage device includes a body defining a plurality of openings capable of holding at least one rotatable drill bit that may be mounted on a drill and used to form a bore in bone and at least one implant container that holds an implant capable of being placed in the bore. | 2010-02-04 |
| 20100028829 | CHEMICALLY ACTIVATED DENTAL BLEACHING TRAYS - Dental treatment trays and strips used to deliver a dental bleaching composition to a person's teeth are formed from a moisture resistant barrier material and include a bleaching agent destabilizer disposed on an inner treatment surface of the barrier layer that is positioned against the person's teeth during use. The bleaching agent destabilizer may be compounded with the moisture resistant material or otherwise disposed relative to the barrier layer so that at least some destabilizer is positioned on the inner treatment surface of the tray or strip so as to contact the dental bleaching composition during use. | 2010-02-04 |
| 20100028830 | Dental Irrigator - The invention is a dental irrigator for delivering irrigant solution from an irrigation solution reservoir to the site of a dental procedure. The irrigator comprises: a hollow dental tool modified by the addition of one or more curved blades either formed directly on the neck of the tool or on a sleeve attached coaxially to the neck, one or more inlets associated with each of the curved blades, a housing that provides a watertight volume surrounding the inlets while allowing the tool to be freely moved with respect to the housing, and a supply hose, which conducts the irrigant solution at relatively low pressure from the reservoir to the housing. When the dental tool is attached to the distal end of a dental hand-piece and the hand-piece is activated causing the tool to move, irrigation solution enters the hollow interior of the neck of the tool and, as a result of the forces created by the motion of the curved blades, is delivered at relatively high pressure to the site. | 2010-02-04 |
| 20100028831 | Dispensing syringe having multiple barrels for discharging a dental composition - A dispensing syringe for dispensing a multi-component dental composition, preferably a two component composition, is provided. The syringe includes a syringe body with multiple elongated barrels for storing the components of the composition; a threaded plunger rod assembly; and a rotatable, threaded connector knob. Preferably, the syringe body has a double-barrel structure and the plunger rod assembly includes two plunger rods that slide within the barrels. The threaded knob has a through-bore with a continuous internal thread for engaging the outer threads of the first and second plunger rods. A dental practitioner manually rotates the knob to displace the first and second plunger rods and discharge the components. The dispensing syringe may further include a dispensing tip containing a static mixing element for mixing the components and dispensing the mixed composition. | 2010-02-04 |
| 20100028832 | Dental device for use in the obturation of a root canal - Kit-of-parts containing
| 2010-02-04 |
| 20100028833 | DRILL FOR DENTAL USE AND WITH MODULATED INERTIA - The invention relates to a drill for use in dentistry. The drill includes an active part, and a shank with a proximal part and a distal part. The proximal part has a variable inertia flywheel. | 2010-02-04 |
| 20100028834 | Blank arrangement - This invention relates to a blank arrangement, with a blank ( | 2010-02-04 |
| 20100028835 | PEDODONTIC/VETERINARY DENTAL CROWN SYSTEM - A dental crown consisting essentially of stabilized zirconia. The dental crown is particularly suited for pedodontic and veterinary applications. The zirconia crown may be formed by one of several manufacturing processes. The formed crown exterior is polished and fine polished to produce an aesthetic outer surface mimicking a natural tooth. Also disclosed is a method for providing a dental crown to a natural tooth and a kit of prefabricated crowns. | 2010-02-04 |
| 20100028836 | PROCESS FOR PRODUCING DENTAL PROSTHESES - In the process for producing dental prostheses such as bridges, crowns implants, etc. from ceramic material, production is carried out at least by way of one CAD/CAM machining station. The ceramic material to be worked consists of an unsintered disk-shaped blank or one which has not been subjected to final sintering, working of the blank into dental prostheses being undertaken at a right angle or quasi-right angle to the parallel or quasi-parallel surfaces of the blank. | 2010-02-04 |
| 20100028837 | FLIGHT MOTION SIMULATOR - A flight motion simulator includes a pitch frame pivotably mounted, and nested for pitching in a roll frame. The roll frame is pivotally mounted to, and nested for rolling in, a base frame. The roll frame and pitch frame are rotatable in unison so as to simulate a roll of an aircraft relative to the base frame. The pitch frame is rotatable relative to the roll frame so as to simulate a pitch of the aircraft relative to the roll frame. A control stick is pivotably mounted to the base frame and pitch frame for controlling and actuating the pitch and roll. A first coupler having at least two degrees of freedom is rotatably mounted to the lower end of the control stick and to the pitch frame. A second coupler also having at least two degrees of freedom is rotatably mounted to the control stick at a lower mid-section thereof to an upper end of a post mounted to the base frame. This aids the pilot in actuating pitch and roll as the control stick provides mechanical advantage to the pilot providing manual inputs to the upper end of the control stick. The two degrees of freedom of the first and second couplers include rotation about a longitudinal axis and rotation about a lateral axis. | 2010-02-04 |
| 20100028838 | Rotatable Drawing Device - A rotatable drawing device intended for children. The top and sides of said device are attached and are formed to accept drawing mediums such as chalk, water or dry erase marker used to color, write and draw upon this device. The top of the drawing device has a recessed portion to hold the drawing medium when not in use. The drawing device rests upon and is attached to a base platform on which it rotates. The drawing unit is spaced above the base platform so that the drawing cylinder may rotate about its center axis. Feet adhered to the bottom of the base hold the invention off the floor. | 2010-02-04 |
| 20100028839 | METHODS AND SYSTEMS FOR EVALUATING MEMORY AGENTS - The present invention provides methods and systems for identifying, evaluating, and testing various compounds as memory agents and regimens as training protocols related to memory enhancement and/or impairment. Such methods and systems may test any compounds or protocols, including the memory agents and training protocols described herein. The methods can comprise combining training protocols with the general administration of memory agents. In some embodiments, the present invention may involve identifying, selecting, testing, evaluating or assessing a compound as a drug candidate for a memory agent, for example, as one effective for enhancing or impairing memory. | 2010-02-04 |
| 20100028840 | EDUCATIONAL TOOL - A wave function of quantum mechanics is regarded as a vector potential having a component only in a θ-direction of polar coordinates (r, θ, φ). The result of applying a rotational vector operation to the vector potential is regarded as a magnetic field. The result of applying the rotational vector operation to the magnetic field is regarded as an electric field. A drawing on a plane or a three-dimensional model is configured to express both the magnetic and electric fields or one of the fields. The drawing or the model, as an educational tool, visualizes the figure of an atom, enables educands to have a close feeling toward sciences, and especially quantum mechanics, and enables them to have concrete images of various physical phenomena in the atom. The present invention, therefore, provides an educational tool that prevents educands from going away from sciences due to lack of an adequate educational tool of sciences and raises their interest in quantum mechanics inclined to be biased only toward mathematical research. | 2010-02-04 |
| 20100028841 | Mind-Body Learning System and Methods of Use - The invention describes a method of training, the training resulting in an individual experiencing enhanced intimacy and having an improved sensual and sexual experience. The invention also can comprise a kit comprising a number of training materials and devices, including booklets, audio tapes, video tapes, CDs, DVDs, CD-ROMs, Computers, and Computers connected to Servers via various internet connections or wireless connections that can be used by an individual to be trained to experience enhanced intimacy and have an improved sensual and sexual experience. | 2010-02-04 |
| 20100028842 | Interactive Learning Toy - An interactive learning toy comprises: a main portion including a sensing and sound-emitting device, and plural sensed devices. The sensing and sound-emitting device includes a center processor unit connected to a speaker, a power, a memory, a sensor and a switch. The respective sensed devices include a memory and a sensor. By such arrangements, the interactive learning toy can emit different sounds when different sensed devices are attached to the main portion to improve the game and learning interest. In addition, the sensed devices can be designed in different forms corresponding to the passive audio data pre-recorded in the memory of the main portion to create a connection between the vision and audition to improve the learning effect and game interest. | 2010-02-04 |
| 20100028843 | SPEECH ACTIVATED SOUND EFFECTS BOOK - A speech activated book having a cover disposed to receive an elongated housing. The speech-activated book could also include at least one page disposed along a portion of a binding area of the book. The page includes text having at least one trigger word. The speech-activated book could also include an audio circuit that, in response to detecting an audible representation of the trigger word, could provide an associated sound effect stored in memory. The elongated housing could be secured to the cover by at least one of: glue, an adhesive, a heat-set binding, a screw, a tab, a wire, a spiral connector, a rivet, a staple, a fastener, and a retainer. | 2010-02-04 |
| 20100028844 | METHOD FOR TRANSFORMING AN UNDER-ACHIEVING STUDENT INTO A SUPERIOR STUDENT - A method of transforming an under-achieving student into a superior student comprising monitoring the student's grade level in at least one academic course and automatically terminating the student's access to at least one privilege whenever the student's grade level falls below a predetermined level. The method may also be used to reward a student that maintains a grade level above a predetermined threshold. | 2010-02-04 |
| 20100028845 | TRAINING SYSTEM AND METHOD - A training system comprising: a terminal, a cpu located in the terminal; a storage means in signal communication with the cpu; an input means located on the terminal and in signal communication with the cpu; a terminal screen located on the terminal and in signal communication with the cpu; a training module located on the storage means, the training module comprising: at least one training video with user selectable chapter markers located at programmed intervals on the training video; an employee evaluations module located on the storage means that alerts a supervisor when an employee should receive training on a specific subject, when an employee has watched certain videos and has completed training, and that provides results and analyses of all employee quizzes to the a person directed by an operator of the training system. | 2010-02-04 |
| 20100028846 | SYSTEMS AND METHODS FOR COMPUTERIZED INTERACTIVE SKILL TRAINING - The present invention is directed to interactive training, and in particular, to methods and systems for computerized interactive skill training. An example embodiment provides a method and system for providing skill training using a computerized system. The computerized system receives a selection of a first training subject. Several related training components can be invoked, such as reading, watching, performing, and/or reviewing components. In addition, a scored challenge session is provided, wherein a training challenge is provided to a user via a terminal, optionally in video form. | 2010-02-04 |
| 20100028847 | SYSTEM AND METHOD OF INTEGRATING LEVELS OF EDUCATIONAL PROGRAMS - Adapting to a secondary and post secondary integration process with secondary and post secondary program gives student the opportunity to receive a secondary diploma and earn post secondary credit and/or diploma. The secondary is located in proximity to a post secondary campus or on a uniquely constructed campus in order to share resources and facilities. The student is evaluated to ascertain academic aptitudes and capabilities. The evaluation involves administering a post secondary placement exam prior to scheduling and reviewing prior school transcripts. An administrator of the secondary assigns a class schedule to the student based on the assessment of the student. The class schedule has a combination of secondary classes and post secondary classes. The secondary class is scheduled in accordance with the post secondary class. The student attends the secondary class and post secondary class according to the class schedule. The student earns post secondary credit and/or diploma upon passing the post secondary class. The secondary offers special classes for the student to adapt to the post secondary classes. | 2010-02-04 |
| 20100028848 | Compositions and Methods of Using siRNA to Knockdown Gene Expression and to Improve Solid Organ and Cell Transplantation - This invention describes compositions and methods using siRNA to target various genes expressed in cells of transplanted organs or tissues and/or genes expressed in the host to improve the success of the transplantation. | 2010-02-04 |
| 20100028849 | NOVEL PROCESS FOR DEVITALIZED/ACELLULAR TISSUE FOR TRANSPLANTATION - A method for processing tissue to produce a devitalized acellular matrix for transplantation comprises soaking the tissue in a first processing solution having a pH below 7 to reduce protease activity, periodically infusing ozone into the first processing solution to devitalize the tissue and reduce bioburden, and soaking the tissue in a second processing solution to remove cellular debris. The present invention also includes a system for processing the tissue. The devitalized acellular matrix acts as a scaffold for cellular ingrowth when transplanted into a recipient to form new tissue. | 2010-02-04 |
| 20100028850 | PERFUSION REGULATION - A system and method for regulating cooperatively the pressures and flows of input vessels such as both the portal vein and hepatic artery for the liver. This invention solves problems of less-than-therapeutic portal vein flow during perfusion preservation by implementing cooperative regulation between the inputs, e.g., portal vein and hepatic artery pumping systems, on an organ preservation apparatus. It includes an algorithm that adapts to the situation wherein the portal vein has reached minimum flow and maximum pressure. The cooperative regulation algorithm senses the problem with the portal vein and solves it by adjusting the hepatic artery flow conditions. | 2010-02-04 |
| 20100028851 | Multi-Lineage Progenitor Cells - Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described. | 2010-02-04 |
| 20100028852 | METHODS AND REAGENTS FOR PRESERVING RNA IN CELL AND TISSUE SAMPLES - This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue. | 2010-02-04 |
| 20100028853 | OPTICAL DETERMINATION OF LIVING VS. NON LIVING CELLS - A method of determining whether a cell sample in a medium contains living or dead cells of a predetermined target cell type is disclosed. The method includes preparing a testing substrate by attaching a binding molecule thereto, the binding molecule having the property of immobilizing cells of the target cell type upon coming in contact therewith. The method also includes incorporating a colorimetric indicator onto the testing substrate, performing a first spectrographic analysis of the calorimetric indicator, determining a change in pH of the medium based upon a second spectrographic analysis of the colorimetric indicator as compared to the first, and determining the portion of live target cells in the medium based upon the change in pH. | 2010-02-04 |
| 20100028854 | METHODS FOR MODELING INFECTIOUS DISEASE AND CHEMOSENSITIVITY IN CULTURED CELLS AND TISSUES - The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided are methods using a rotating wall vessel to predict Chemosensitivity of cells and tissues to toxins and chemotherapeutic agents. These culture conditions potentiate spatial colocalization and three-dimensional assembly of individual cells into large aggregates which more closely resemble the in vivo tissue equivalent. In this environment, dissociated cells can assemble and differentiate into macroscopic tissue aggregates several millimeters in size. These culture conditions allow for better cellular differentiation and formation of three-dimensional cellular aggregates, more efficient cell-to-cell interactions, the in in vivo-like exchange of growth factors and greater molecular scaffolding facilitating mechanical stability for cells. The suspension culture system offers a new approach for studying microbial infectivity from the perspective of the host-pathogen interaction and also for analyzing chemosensitivity to toxins and chemotherapeutic agents. | 2010-02-04 |
| 20100028855 | DETECTION OF INFLUENZA VIRUS TYPE B - The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses. | 2010-02-04 |
| 20100028856 | METHOD TO DETECT VIRUS RELATED IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF HEPATITIS B VIRUS INFECTION - This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HBV-associated immunological markers in a serum sample for the diagnosis of HBV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HBV related antigens or antibodies used for the diagnosis of HBV infection. | 2010-02-04 |
| 20100028857 | Method for Detecting and for Removing Endotoxin - The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins. | 2010-02-04 |
| 20100028858 | HIGH SENSITIVITY ASSAY FOR MOLECULAR TYPING OF BIOLOGICAL SAMPLE, PROBES AND A KIT THEREOF - The present invention relates to a high sensitivity assay for molecular typing of a biological sample using surface-enhanced Raman scattering (SERS) including resonance scattering (SERRS); capture probes for capturing nucleic acid; a detector probe to detect captured nucleic acid; a kit for molecular typing of biological sample using surface-enhanced Raman scattering (SERS) including resonance scattering (SERRS); and lastly a method of manufacturing said kit. | 2010-02-04 |
| 20100028859 | Hyper-Spectral Imaging and Analysis of a Sample of Matter, and Preparing a Test Solution or Suspension Therefrom - Method for hyper-spectral imaging and analysis of a sample of matter, for identifying and characterizing an object of interest therein. Preparing test solution or suspension of the sample, including adding thereto a spectral marker specific to object of interest, such that if object of interest is in test solution or suspension, object of interest becomes a hyper-spectrally active target which is hyper spectrally detectable and identifiable; adding to test solution or suspension a background reducing chemical, for reducing background interfering effects caused by presence of objects of non-interest in test solution or suspension, thereby increasing hyper spectral detectability of hyper spectrally active target in test solution or suspension; generating and collecting hyper-spectral image data and information of test solution or suspension; and, processing and analyzing thereof. Exemplary objects of interest are biological agents—bacteria ( | 2010-02-04 |
| 20100028860 | Porcine Reproductive and Respiratory Syndrome Isolates and Methods of Use - A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain. | 2010-02-04 |
| 20100028861 | Probe set and method for identifying hla allele - Provided is a probe set that is useful for identifying each allele of HLA individually, and a method of identification of an allele of HLA by the use thereof for each type. The probe set is composed of probes that cover all of the partial sequences that contain a unique base to each allele. Using this probe set HLA contained in a specimen is identified. | 2010-02-04 |
| 20100028862 | BACTERIAL REPLICATION SYSTEMS AND METHODS - Reconstituted bacterial replication assemblies and methods for their use are provided. | 2010-02-04 |
| 20100028863 | HIGH THROUGHPUT ASSAY FOR CANCER CELL GROWTH INHIBITION - A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media transfected with the subject compound, and enables live colony growth determination and imaging. | 2010-02-04 |
| 20100028864 | REAGENTS AND METHODS FOR DETECTING NEISSERIA GONORRHOEAE - This invention provides compositions and methods for detecting | 2010-02-04 |
| 20100028865 | Method for Identifying Regulatory T Cells - The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells. | 2010-02-04 |
| 20100028866 | DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Nato3 - The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell. | 2010-02-04 |
| 20100028867 | LRRTM1 Compositions and Methods of Their Use for the Diagnosis and Treatment of Cancer - Microarray analysis, confirmed by RT-PCR, demonstrated that mRNA from certain cancer tissues, for example, ovarian cancer tissue, pancreatic cancer tissue, and colorectal cancer tissue, hybridizes specifically and preferentially to LRRTM1. LRRTM1 is a leucine-rich repeat transmembrane protein overexpressed on the surface of cancer cells compared to normal tissues and thus provides a therapeutic target for treating cancer. Modulators of LRRTM1, highly expressed in cancerous as compared to normal tissues, are provided for the diagnosis and treatment of proliferative disorders such as cancer. The invention further provides methods of treating cancer with therapeutic agents directed toward LRRTM1. | 2010-02-04 |
| 20100028868 | Responsiveness to Therapy for Liver Disorders - Sets of nucleic acids and methods for predicting a subject's responsiveness to therapy for liver disorders. | 2010-02-04 |
| 20100028869 | METHOD TO ASSESS SUSCEPTIBILITY TO ANDROGENIC ALOPECIA - The present invention relates to a method to assess the susceptibility to androgenetic alopecia comprising detecting the presence of polymorphisms in the EDA2R gene. | 2010-02-04 |
| 20100028870 | DESIGN OF SYNTHETIC NUCLEIC ACIDS FOR EXPRESSION OF ENCODED PROTEINS - Methods for determining a property that affects expression of polynucleotides are provided. A plurality of polynucleotides each encoding a polypeptide sequence is constructed. A frequency that a sequence element is used in a first polynucleotide is different than in a second polynucleotide. Each polynucleotide is expressed in an expression system to obtain an expression property value thereby constructing a dataset that contains, for each respective polynucleotide, sequence element occurrence in the respective polynucleotide and the measured expression property value of the respective polynucleotide. A model is computed that describes variation in the measured expression property values as a function of a plurality of variables and weights. From the model, a property that affects expression of polynucleotides in the expression system is determined, where the property is an effect that the frequency of occurrence of one or more sequence elements has on the expression property of polynucleotides in the expression system. | 2010-02-04 |
| 20100028871 | Light-inducible and rhythmically expressed genes and method for screening substances that affect an internal clock system - A method for screening a substance that affect an internal clock system in an organism, comprising the detection of the expression level of a gene exhibiting a light-inducible and rhythmic expression in a circadian manner, which is typically expressed in the suprachiasmatic nucleus of mammalian, such as for example, Dusp4, Snk, Slc39a6 or Nnat. | 2010-02-04 |
| 20100028872 | Methods for the Detection of Cancer - Methods, compositions, and kits for the detection of cancer, particularly renal cancer, are provided. | 2010-02-04 |
| 20100028873 | METHODS AND MEANS FOR NUCLEIC ACID SEQUENCING - The present invention provides a nucleic acid sequencing method. The method comprises enriching a nucleic acid sample for target nucleic acids, where the nucleic acid sample is enriched through at least a first round of hybridization selection and amplification, and a second round of hybridization selection and amplification. The enriched nucleic acids are in a form convenient for sequencing with the Cantaloupe sequencing technology, which employs shotgun sequencing by hybridization (SBH) of immobilized rolling circle amplicons. | 2010-02-04 |
| 20100028874 | HEPATITIS C VIRUS INFECTION BIOMARKERS - A signature set of genes associated with hepatitis C virus infection is described. | 2010-02-04 |
| 20100028875 | METHOD FOR DIAGNOSING CANCER BY DETECTING THE METHYLATION OF TRANSITIONAL ZONES - The present invention relates to a method for diagnosing cancer and predicting metastasis or prognosis by measuring the methylation of transitional zones and a primer for detecting the methylation. According to the present invention, a novel transitional zone is understood and a primer for detecting the methylation of the zone is provided, indicating that the present invention contributes to increase accuracy and liability of cancer prediction by measuring the methylation of transitional zones and chromosomal loss at the same time. | 2010-02-04 |
| 20100028876 | DIAGNOSTIC TESTS USING GENE EXPRESSION RATIOS - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets of genes can be used to discriminate between normal and malignant cells or tissues, and between classes of malignant cells or tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumour progression/regression also are provided. | 2010-02-04 |
| 20100028877 | MOLECULE FOR PROVIDING A STANDARD FOR THE QUANTITATIVE ANALYSIS OF THE METHYLATIONS STATUS OF A NUCLEIC ACID - The invention refers to a nucleic acid for providing a standard in the quantitative bisulfite based analysis of the methylation status of a DNA molecule with a given sequence, wherein the given sequence comprises at least one CpG position that is to be analyzed for its methylation status. This nucleic acid comprises: a first and a second sequence portion, both of which comprise at least part of the given sequence with at least one CpG position, wherein in the first sequence portion, all of the CpG positions represent the methylated status, and in the second sequence portion, all of the CpG positions represent the unmethylated status. | 2010-02-04 |
| 20100028878 | Modulators of UDP-glucose ceramide glucosyltransferase for treating acne or hyperkeratinization - An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperkeratinization; methods for the in vitro diagnosis or prognosis of these pathologies are also described. | 2010-02-04 |
| 20100028879 | Modulators of HSD17b7 for treating acne or hyperseborrhea - An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or in vitro prognosis of these pathologies are also described. | 2010-02-04 |
| 20100028880 | METHOD FOR SUSTAINED EXPRESSION OF AN EXOGENOUS GENE - A method for sustained expression of an exogenous gene forms a circular episomal plasmid to solve the problem of transient expression of baculovirus in the transduced mammalian cells caused by the dilution and degradation when mammalian cells replicate and also prevents dysfunctional cell metabolism. | 2010-02-04 |
| 20100028881 | EXTRACELLULAR AND MEMBRANE-ASSOCIATED PROSTATE CANCER MARKERS - This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein. | 2010-02-04 |
| 20100028882 | METHODS FOR DIAGNOSING OSTEOARTHRITIS - Methods are disclosed for assessing risk of developing osteoarthritis. Said methods comprise determining the cellular localizations, blood or synovial fluid concentrations, sumoylation states and post-translational modifications of pituitary homeobox transcription factor 1 (pitx-1) repressor proteins, identifying mutations in genes which encode said proteins and identifying any mutations or post-translational modifications causing the nuclear accumulation or retention of said proteins. Said proteins include prohibitin (PHB-I), prohibitone (PHB-2) and B cell lymphoma-6 transcriptional repressor interacting co-repressor (BCoR). | 2010-02-04 |
| 20100028883 | METHOD FOR EVALUATION OF TISSUE PRESERVATION SOLUTION - The present invention provides a method for evaluating preservative effect of a tissue preservation solution, comprising immersing a mammalian tissue introduced with a luminescence or fluorescence labeling gene in the tissue preservation solution, measuring a luminescence or fluorescence level by the labeling gene in the tissue after immersion, and evaluating the preservative effect of the tissue preservation solution based on the luminescence or fluorescence level. | 2010-02-04 |
| 20100028884 | Detection of penicillin tolerance in group B streptococcus: single nucleotide polymorphisms in penicillin binding protein 4 - Disclosed are methods of detecting penicillin tolerance in Group B | 2010-02-04 |
| 20100028885 | Labelled nucleotides - Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. | 2010-02-04 |
| 20100028886 | METHODS OF DETERMINING PROPERTIES OF MOLECULES - This disclosure features, inter alia, methods for determining at least one property of a nucleic acid. The methods include: (a) fixing the nucleic acid on a planar surface; (b) digesting the nucleic acid into fragments with at least one enzyme; (c) imaging the nucleic acid; and (d) analyzing the imaged nucleic acid to determine the property of the nucleic acid, wherein no internal nucleic acid standard is added during the method. | 2010-02-04 |
| 20100028887 | METHOD, KIT AND SYSTEM FOR COLLECTING AND PROCESSING SAMPLES FOR DNA AND RNA DETECTION - This invention relates to a method, kit and system for collecting and processing of samples to release and treat DNA and RNA for gene sequence detection. The method described here in provides for rapid and convenient release, and recovery of DNA and RNA from tissues and cellular materials. | 2010-02-04 |
| 20100028888 | METHODS FOR PRODUCING A PAIRED TAG FROM A NUCLEIC ACID SEQUENCE AND METHODS OF USE THEREOF - Methods for producing a paired tag from a nucleic acid sequence are provided in which the paired tag comprises the 5′ end tag and 3′ end tag of the nucleic acid sequence. In one embodiment, the nucleic acid sequence comprises two restriction endonuclease recognition sites specific for a restriction endonuclease that cleaves the nucleic acid sequence distally to the restriction endonuclease recognition sites. In another embodiment, the nucleic acid sequence further comprises restriction endonuclease recognition sites specific for a rare cutting restriction endonuclease. Methods of using paired tags are also provided. In one embodiment, paired tags are used to characterize a nucleic acid sequence. In a particular embodiment, the nucleic acid sequence is a genome. In one embodiment, the characterization of a nucleic acid sequence is karyotyping. Alternatively, in another embodiment, the characterization of a nucleic acid sequence is mapping of the sequence. In a further embodiment, a method is provided for identifying nucleic acid sequences that encode at least two interacting proteins. | 2010-02-04 |
| 20100028889 | COMPANION DIAGNOSTIC ASSAYS FOR CANCER THERAPY - Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive Bcl-2 family inhibitor therapy and of determination of patient response to the therapy. | 2010-02-04 |
| 20100028890 | COMPOSITIONS, METHODS, AND KITS FOR ANALYZING DNA METHYLATION - Compositions, methods, and kits for reducing strand amplification bias using bisulfite treated gDNA are provided. Methods for detecting and for quantitating the amplified bisulfite treated gDNA and inferring the presence, absence, and/or degree of methylation of target cytosine(s) in the gDNA are also provided. Such methods typically employ tailed first primer pairs, which can, but need not comprise nucleotide analogs, and optionally second primer pairs. | 2010-02-04 |
| 20100028891 | METHOD FOR DETERMINING THE SENSITIVITY OR RESISTANCE OF RETROVIRUS ISOLATES TO MOLECULES, THERAPEUTIC RETROVIRAL TREATMENTS BASED ON VIRAL PROTEASE INHIBITORS AND DIAGNOSTIC KITS - A method of determining sensitivity or resistance of isolates of HIV retroviruses to a molecule includes a) amplifying sequences coding for a protease of a retrovirus to be studied, with or without the or some of amino acid sequences situated upstream and downstream of a cleavage site of a precursor in which the amino acid sequences are situated, b) recombining fragments of DNA, a final product of the amplification, and an expression vector allowing expression of sequence coding for the protease of the retrovirus to be studied under control of a known inducible promoter through co-transformation of the vector and the DNA fragments with at least one yeast cell, c) culturing co-transformed yeast cell or cells to obtain a sufficient number of transformants to perform a sensitivity or resistance test, and recovering transformants issuing from the co-transformed cell, on any suitable medium, d) incubating the transformants in the presence of a molecule to be tested, e) qualitatively or quantitatively analyzing the living cells, and f) deducing the sensitivity or resistance phenotype. | 2010-02-04 |
| 20100028892 | YEAST BASED EXPRESSION OF PROTEASES AND METHODS OF USE - This disclosure generally relates to components and methods of using a high throughput screening (HTS) systems for intracellular proteases, using Caspases as a prototype. Genetic systems are disclosed for monitoring exogenous caspase activation pathways in the yeast, | 2010-02-04 |
| 20100028893 | METHODS AND COMPOSITIONS FOR PHARMACOGENETIC ANALYSIS OF ANTI-INFLAMMATORY DRUGS IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY DISEASES - The invention provides methods and compositions for the pharmacogenetic analysis of anti-inflammatory compounds, especially for the pharmacogenetic association of responsiveness to rheumatoid arthritis medications that target TNFα. | 2010-02-04 |
