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05th week of 2011 patent applcation highlights part 42
Patent application numberTitlePublished
20110027716ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION, COMPOUND AND METHOD OF FORMING PATTERN USING THE COMPOSITION - According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes any of the compounds (A) of general formula (I) below that when exposed to actinic rays or radiation, generates an acid and a resin (B) whose rate of dissolution into an alkali developer is increased by the action of an acid. (The characters used in general formula (I) have the meanings mentioned in the description.)2011-02-03
20110027717PHOTORESIST COMPOSITION - A photoresist composition contains a polyol compound and a vinyl ether compound, which polyol compound having an aliphatic group and an aromatic group bound alternately, and which aromatic group has an aromatic ring and two or more hydroxyl groups on the aromatic ring. The polyol compound can be prepared, for example, through an acid-catalyzed reaction, such as a Friedel-Crafts reaction, between an aliphatic polyol and an aromatic polyol. The aliphatic polyol is preferably an alicyclic polyol, whereas the aromatic polyol is preferably hydroquinone.2011-02-03
20110027718RADIATION-SENSITIVE RESIN COMPOSITION AND COMPOUND - A radiation-sensitive resin composition includes a compound shown by a formula (1) in which R2011-02-03
20110027719PHOTOMASK ETCHING METHOD FOR CHEMICAL VAPOR DEPOSITION FILM - The present invention discloses a photomask etching method for a CVD film, which comprises steps: exposing an optical resin layer to an ultraviolet ray through a photomask; baking the optical resin layer to gasify the exposed portion of the optical resin layer with the unexposed portion remaining; using a CVD method to form a film on the substrate filling the gasified area and covering the remaining portion of the optical resin layer; exposing the entire film to the ultraviolet ray, and baking the entire substrate at a high temperature to gasify the remaining optical resin layer and remove the film adhering to the remaining optical resin layer to obtain a patterned film. The present invention can achieve higher accuracy of the patterned film with lower equipment cost and lower manufacturing cost.2011-02-03
20110027720Method and Device for Fabricating Volume Bragg Gratings - A system for recording multiple volume Bragg gratings (VBGs) in a photo thermo-refractive material is configured to implement a method which provides for irradiating the material by a coherent light through a phase mask. The system has a plurality of actuators operative to displace the light source, phase mask and material relative to one another so as to mass produce multiple units of the material each having one or more uniformly configured VBGs.2011-02-03
20110027721LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD - A map of the surface of a substrate is generated at a measurement station. The substrate is then moved to where a space between a projection lens and the substrate is filled with a liquid. The substrate is then aligned using, for example, a transmission image sensor and, using the previous mapping, the substrate can be accurately exposed. Thus the mapping does not take place in a liquid environment.2011-02-03
20110027722AROMATIC RING-CONTAINING POLYMER FOR RESIST UNDERLAYER, RESIST UNDERLAYER COMPOSITION INCLUDING THE SAME, AND METHOD OF PATTERNING DEVICE USING THE SAME - An aromatic ring-containing polymer for a resist underlayer, the polymer including a unit represented by the following Chemical Formula 1:2011-02-03
20110027723MEASURING APPARATUS, OPTICAL SYSTEM MANUFACTURING METHOD, EXPOSURE APPARATUS, DEVICE MANUFACTURING METHOD, AND PROCESSING APPARATUS - The present invention provides a processing apparatus which executes sampling of data and represents the sampled data by linear combination of orthogonal functions, the apparatus including a device configured to execute the sampling, and a processor configured to process the data sampled by the device, wherein the processor is configured, if the data sampled by the device includes an invalid sampling point, to obtain a degree of break of orthogonality of an orthogonal function system caused by the invalid sampling point, and to evaluate reliability of the sampling based on the obtained degree.2011-02-03
20110027724SPATIAL LIGHT MODULATING UNIT, ILLUMINATION OPTICAL SYSTEM, EXPOSURE APPARATUS, AND DEVICE MANUFACTURING METHOD - There is disclosed a spatial light modulating unit comprising, a spatial light modulator having a plurality of optical elements arrayed two-dimensionally and controlled individually, and an exit-side optical system which guides light having traveled via the plurality of optical elements of the spatial light modulator, wherein the exit-side optical system is configured so that zero-order light having traveled via a surface portion other than the plurality of optical elements and approximately parallel to an array plane where the plurality of optical elements are arrayed, does not pass through an entrance pupil of the exit-side optical system.2011-02-03
20110027725POLYOL COMPOUND FOR PHOTORESIST - A polyol compound for photoresists has at least one aliphatic group and at least one aromatic group bound to each other alternately, in which the aromatic group has at least one aromatic ring and two or more hydroxyl groups bound to the aromatic ring. The polyol compound for photoresists can be prepared through an acid-catalyzed reaction, such as a Friedel-Crafts reaction, between an aliphatic polyol and an aromatic polyol. The aliphatic polyol is preferably an alicyclic polyol. The aromatic polyol is preferably hydroquinone.2011-02-03
20110027726POLYMER COMPOUND FOR PHOTORESIST - A polymer compound for photoresists contains alkali-soluble groups being protected by protecting groups capable of leaving with an acid, and is thereby insoluble or sparingly soluble in an alkaline developer, in which part or all of the protecting groups are multifunctional protecting groups each protecting two or more alkali-soluble groups. The alkali-soluble groups may be phenolic hydroxyl groups. The polymer compound may correspond to a polyol compound having an aliphatic group and an aromatic group bound to each other alternately, the aromatic group having an aromatic ring and two or more hydroxyl groups bound to the aromatic ring, except with phenolic hydroxyl groups of the polyol compound being protected by protecting groups capable of leaving with an acid.2011-02-03
20110027727Substrate developing method, substrate processing method and developing solution supply nozzle - According to the present invention, an anti-reflective film formed under a resist film is removed in a photolithography process of a wafer without affecting the resist film. According to the present invention, in a photolithography process of a substrate, an anti-reflective film having solubility in the developing solution is formed and thereafter a resist film is formed. In development treatment after exposure processing, a developing solution is supplied to the substrate to develop the resist film. At an instant when the development of the resist film is finished, a second developing solution lower in concentration than the developing solution is supplied to the substrate. Only the anti-reflective film is dissolved and removed by the supply of the second developing solution.2011-02-03
20110027728Size scaling of a burner - A method for upscaling the size of a burner of a gas turbine engine including a burner housing is provided. The burner is provided with a mixture of fuel and air at an upstream end from a premixing channel that sustains a main flame at a downstream end of the burner. The premixing channel is defined at the exit by a circular inner wall formed by an inner quarl section and a circular outer wall formed by an outer quarl section. The burner may be increased in size by adding a quarl section outside and circumferentiating the quarl section and forming an annular space between the added quarl section and the existing outer quarl section and by adding a premixing channel defined at the exit by a circular inner wall formed by the previously outmost quarl section and the circular outer wall formed by the added quarl section.2011-02-03
20110027729OFF-GAS FLARE - An off-gas flare system for disposing of a waste gas stream containing BTEX and VOC contaminants, and for safely handling slugs of excess liquids entrained in the waste gas stream. The flare system includes a flare stack, an enclosed steam tank disposed within the flare stack for receiving the waste gas stream and vaporizing any liquids in the waste gas stream into vapors, and an enclosed liquid tank disposed below the steam tank and in fluid communication with the steam tank for receiving the heated waste gas and liquid vapors and for temporarily containing any excess non-vaporized liquids. The flare also includes a waste gas burner disposed in the flare stack adjacent the steam tank and in fluid communication with the liquid tank, and a continuous means for igniting the waste gas burner.2011-02-03
20110027730COMBUSTION ACCELERATOR FOR ENGINES AND BURNER - Described is an invention for the catalytic acceleration of combustion processes of fuels and heating oils, comprising dimensionally stable, tin-containing elements in a flow vessel for the production of tin organic compounds in the form of a flow vessel having an alloy structure or pads in a fuel filter container or another container, which due to the composition and ignition thereof during the appearance of light result in ignition or a flame having an extremely fast ignition distribution, therefore avoiding soot and lowering the nitrogen oxide concentrations.2011-02-03
20110027731Combustion Method and Apparatus - A burner has a port facing into a combustion chamber along an axis. A secondary fuel injector structure has secondary fuel injection ports that face into the combustion chamber at locations spaced radially outward from the burner port. A tertiary fuel injector structure has tertiary fuel injection ports that face into the combustion chamber in directions perpendicular to the axis at locations spaced axially downstream from the secondary fuel injection ports.2011-02-03
20110027732BURNER OF A GAS TURBINE - The burner of a gas turbine includes two or more part cone shells arranged offset with respect to one another and defining a cone shaped chamber with longitudinal tangential slots for feeding air therein. A lance carrying a liquid fuel nozzle arranged centrally in the cone shaped chamber is also provided. A portion of the nozzle facing the cone shaped chamber is divergent in shape. A diffuser angle (α) between the wall of the nozzle and a longitudinal axis of the cone shaped chamber is less than 5°. A diverging portion of the nozzle has a diffuser length to nozzle diameter ratio comprised between 2-6. The nozzle diameter is the smaller diameter of the diverging portion.2011-02-03
20110027733BURNER - The object is to prevent damage to and overheating of an electric wire for electric discharge/ignition of a burner, thereby increasing its life, without increase in cost.2011-02-03
20110027734SYSTEM AND APPARATUS FOR APPLYING AN ELECTRIC FIELD TO A COMBUSTION VOLUME - According to an embodiment, combustion in a combustion volume is affected by at least two sequentially applied non-parallel electric fields. According to an embodiment, a combustion volume is equipped with at least three individually modulatable electrodes. According to an embodiment, an electric field application apparatus for a combustion volume includes a safety apparatus to reduce or eliminate danger.2011-02-03
20110027735CANDLE HAVING A PLANAR WICK AND METHOD OF AND EQUIPMENT FOR MAKING SAME - A candle having a body of a meltable fuel and a planar wick. When lit, the candle provides a unique flame formation, usable in a variety of decorative applications. The wick can be configured to evenly deplete the meltable fuel, while allowing for candles having relatively large and unique body configurations. The body of candle and/or the wick may include scented oil to promote the release of fragrance upon heating. The wick preferably is formed of wood, thereby providing an acoustic contribution to ambiance and improved combustion that generates less soot than conventional cotton wick candles.2011-02-03
20110027736CANDLE HAVING A PLANAR WICK AND METHOD OF AN EQUIPMENT FOR MAKING SAME - A candle having a body of a meltable fuel and a planar wick. When lit, the candle provides a unique flame formation, usable in a variety of decorative applications. The wick can be configured to evenly deplete the meltable fuel, while allowing for candles having relatively large and unique body configurations. The body of candle and/or the wick may include scented oil to promote the release of fragrance upon heating. The wick preferably is formed of wood, thereby providing an acoustic contribution to ambiance and improved combustion that generates less soot than conventional cotton wick candles.2011-02-03
20110027737CANDLE HAVING A PLANAR WICK AND METHOD OF AND EQUIPMENT FOR MAKING SAME - A candle having a body of a meltable fuel and a planar wick. When lit, the candle provides a unique flame formation, usable in a variety of decorative applications. The wick can be configured to evenly deplete the meltable fuel, while allowing for candles having relatively large and unique body configurations. The body of candle and/or the wick may include scented oil to promote the release of fragrance upon heating. The wick preferably is formed of wood, thereby providing an acoustic contribution to ambiance and improved combustion that generates less soot than conventional cotton wick candles.2011-02-03
20110027738SUPPORTING STRUCTURE WITH HEIGHT DIFFERENCE AND VAPOR CHAMBER HAVING THE SUPPORTING STRUCTURE - A vapor chamber having supporting structure with height difference, includes a shell, tissue wick structure, working fluid filled into the shell and supporting structure with height difference, disposed over inner walls of the shell, accommodated in the shell, abutted against the wick structure, and including first corrugated piece and second corrugated piece, both of which are connected to each other. The longitudinal distance between top and bottom of the first corrugated piece is a first amplitude. The longitudinal distance between top and bottom of the second corrugated piece is a second amplitude larger than the first amplitude. Since the second amplitude provides the shell with greater supporting force, when the shell is pressed to make heating element and the shell contact closely, a recessing phenomenon won't occur to the shell, thereby, increasing the contact tightness and promoting the thermally conductive efficiency.2011-02-03
20110027739Premixing-Less Porous Hydrogen Burner - This invention describes a new porous hydrogen burner that is intended to be installed on different types of furnaces requiring a precise monitoring of the thermal flux, and in particular furnaces for vapor-reforming of natural gas or naphtha.2011-02-03
20110027740Method for Heating a SCR System - Process for heating a urea component of a SCR system comprising besides said component, a temperature sensor, a heating device in the component, according to which: 1. the temperature (Tcpt) of the liquid in the component is determined and compared to a 12011-02-03
20110027741VACUUM-FORMED REFRACTORY MEMBER AND METHOD OF MAKING - A refractory member for use in insulating a support beam or other heat-absorptive element in a high temperature furnace as well as a method of producing such members is provided. The refractory member includes a vacuum-formed refractory shape comprised of a fiber material and at least one binder, a reticulated, interconnected mesh embedded within the refractory shape, and an anchor element for securing the refractory member to the heat-absorptive element.2011-02-03
20110027742TRANSLUCENT ZIRCONIA SINTERED BODY, PROCESS FOR PRODUCING THE SAME, AND USE OF THE SAME - A subject of the invention relates to providing a powder for a translucent zirconia sintered body which is necessary for the production of a zirconia sintered body having a high sintered-body density and high strength and giving an excellent sense of translucency, without conducting any special sintering, such as HIP sintering. The invention relates to a technique for obtaining, through normal-pressure sintering, a translucent zirconia sintered body characterized by comprising zirconia which contains 2-4 mol % yttria as a stabilizer and has an alumina content of 0.2 wt % or lower, and by having a relative density of 99.8% or higher and a total light transmittance, as measured at a thickness of 1.0 mm, of 35% or higher. It is preferred that a powder containing 0-0.2 wt % alumina with a particle diameter of 0.01-0.5 μm, having a BET specific surface area of 5-16 m2011-02-03
20110027743Lingual Orthodontic Appliance with Removable Section - An aesthetic, partially removable orthodontic appliance is described, including a polymeric body that conforms to the lingual soft tissue and at least one wire member extending from the polymeric body. Each wire member releasably engages with a respective anchor that is, in turn, connected to the lingual surface of a respective tooth when the polymeric body is moved in a generally gingival direction into abutting relationship with the lingual soft tissue. Other features of the appliance include self-guiding magnetic couplings and couplings based on interlocking mechanical structures that provide releasable engagement between the removable section and the anchors, as well as related methods for making and using the same.2011-02-03
20110027744DENTAL LASER SYSTEM USING MIDRANGE GAS PRESSURE - An improved dental laser system includes a DC power section that rectifies its AC electrical input energy in a format suitable for both CW and pulsed operation, an RF power supply operating in a range of about 40 to 125 MHz and configured for both CW and high peak power pulsing operation, a sealed-off, RF excited CO2011-02-03
20110027745MANDIBLE POSITION INDICATOR AND AUTOMATIC ARTICULATOR FOR MEASURING AND REPLICATING OCCLUSION - One embodiments of the present subject matter include a method that includes fixing a top pantograph to a patient via clutches to the top teeth of the patient, fixing a bottom pantograph to a patient via clutches to the bottom teeth of the patient, optically monitoring the bite of the patient by monitoring the relation of the top pantograph to the bottom pantograph during a bite cycle, storing data relating to the actual bite, fitting the top pantograph and bottom pantograph to casts that are fixed to an automatically adjustable articulator and replicating the bite by moving the automatically adjustable articulator and optically monitoring said movement to replicate the monitored bite using feedback by comparing optical data relating to the replicated bite to the data relating to the actual bite.2011-02-03
20110027746ORAL CARE DEVICE - A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold and a second manifold, a first port and a second port; and means for providing an effective seal of the device within the oral cavity.2011-02-03
20110027747ORAL CARE DEVICE - An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect.2011-02-03
20110027748ORAL CARE SYSTEMS - An oral care system that provides a beneficial effect to an oral cavity of a mammal by using a liquid effective for providing the beneficial effect, where the system includes means for directing the liquid onto a plurality of surfaces of the oral cavity, means for providing the liquid to the means for directing the liquid onto the surfaces of the oral cavity, means for providing reciprocation of the liquid over the plurality of surfaces under conditions effective to provide the beneficial effect; and a reservoir for containing the liquid.2011-02-03
20110027749Water Floss Pick - An apparatus and system for performing dental hygiene comprising a motorized cleaning device comprising a water intake component and an oppositely positioned water exit component; a power component operatively connected to the motorized cleaning device; a floss component attached to the water exit component; a reservoir component operatively connected to the motorized cleaning device; and an aqueduct component attached to the reservoir component, wherein the aqueduct component traverses the motorized cleaning device, wherein the aqueduct component is positioned to direct pressurized water onto the floss component, and wherein the aqueduct component comprises a first end attached to the reservoir component; and a second end that contacts the water intake component of the motorized cleaning device.2011-02-03
20110027750DENTAL PACKAGE, AND METHOD OF PROVIDING A DENTAL MATERIAL FROM A PACKAGE - A device for providing a dental material, which comprises a compartment formed by first and second interconnected layers, and a well adjacent the compartment in the first layer. The second layer partially overlaps the well. The device helps the dental material to be used in a convenient manner, and may be relatively inexpensive to manufacture.2011-02-03
20110027751CAPSULE FOR TOOTH RESTORATIVE MATERIAL - To prevent a bursting sound generated when a mixed and kneaded material obtained by mixing and kneading predetermined amounts of a powder component and a liquid component in a capsule for a tooth restorative material is administrated to a position to be restored in a patient's tooth, the capsule is structured such that a protrusion portion (2011-02-03
20110027752UNITIZED MODULAR ULTRASONIC HANDPIECE CABLE CONNECTOR - A two-part, modular dental handpiece cable connector system that provides a convenient method for fast field replacement of worn or defective handpiece cables without disassembling the dental device. The two parts include a female connector element that mounts within the device housing and a male connector element to attach the cable. The female connector is further defined into two categories: snap-in mounting for enclosed, confined space cabinets and threaded panel mounting for universal attachment.2011-02-03
20110027753APPLICATION TIP - An application tip (2011-02-03
20110027754DENTAL PLIERS WITH ADJUSTABLE BUMPER - A dental pliers design removing teeth and which incorporates a first jaw portion and a second and offsetting handle portion and which permits a rotating, rather than a pulling, force to be applied to a selected tooth or root tip and in order to more quickly and efficiently extract the tooth from the patient's mouth. An adjustable pad support portion is associated with the selected jaw and can further include a threaded bolt which is adjustable relative to a collar associated with the handle in directions towards and away from the jaw. One or more cushioning and replaceable insert can also be seated over a mounting pedestal supporting end of the stem.2011-02-03
20110027755DENTAL IMPLANT FOR LATERAL INSERTION - A dental implant for lateral insertion includes a longitudinal shaft (2011-02-03
20110027756ONE-PIECE INCLINED DENTAL IMPLANT - A one-piece, inclined, dental-implant and corresponding method for the optimal exploitation of areas of relatively abundant bone structure as anchoring regions while preserving biological width and enhancing implant recovery.2011-02-03
20110027757MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME - An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.2011-02-03
20110027758METHODS FOR PROVIDING BENEFICIAL EFFECTS TO THE ORAL CAVITY - A method for providing a beneficial effect to an oral cavity of a mammal, the method including contacting a plurality of surfaces of the oral cavity with a liquid effective for providing the beneficial effect to the oral cavity and providing reciprocation of the liquid over the plurality of surfaces of the oral cavity under conditions effective to provide the beneficial effect.2011-02-03
20110027759METHODS FOR PREPARING CHAIR-SIDE DENTAL CROWNS - The invention provides a method of forming dental restorations, particularly dental crowns. The method involves applying a flexible spacer material having a polymerization system capable of being activated by light to a prepared tooth surface. A composite crown-forming material is dispensed into a transparent plastic matrix. The matrix is placed in the mouth of the patient so the composite material is molded over the tooth surface coated with the spacer material. Then, the composite is irradiated with curing light, through the matrix, so that it hardens to form a dental crown. The crown is removed, trimmed and finished, and then permanently affixed to the tooth.2011-02-03
20110027760DENTAL FILLING COMPOSITION COMPRISING ACIDIC POLYMER COMPOUND AND METHOD OF USING THE SAME - Compositions comprising an acidic polymer compound and a (meth)acrylic copolymer prepared from reactants comprising at least one aliphatic, aromatic, or aralkyl (meth)acrylate monomer and at least one ethylenically unsaturated monomer having a polar group or a siloxane group, and dental filling compositions comprising the composition, and methods of using the compositions2011-02-03
20110027761TRAINING METHOD AND SYSTEM COMPRISING MIXED REAL AND VIRTUAL IMAGES - Training method for the simulation of an operation performed by at least one device which is part of a real apparatus, wherein the method comprises providing to display means overlaid images under controlled depth order of a virtual apparatus, and real images of said device, and providing a simulated response to control means, based on data of the position and behavior of said device and on data of the position and behavior of said virtual apparatus.2011-02-03
20110027762Method and System for Effecting Language Communications - Interaction in a target language among students and native speakers of the language is effected by providing a learning community having a set of language activities in a plurality of languages, including the target language. The activities include communications with others. A student is permitted full access to activities in the target language, while a native speaker in the target language is given access to a subset of activities in a language of his choice in exchange for having carried on a communication with a student in the target language.2011-02-03
20110027763READING EDUCATION TOOL - A reading education tool has detachable letters and/or letter combinations to be attached thereto, and can be stretched to separate the letters and/or letter combinations to enable a learner to sound out individual letters and/or letter combinations and to see the words both in a compact format and a stretched format.2011-02-03
20110027764SYSTEM AND METHOD FOR DETECTING A SPECIFIC COGNITIVE-EMOTIONAL STATE IN A SUBJECT - A system and method is disclosed which detects a specific cognitive-emotional mental state (e.g., passion) in a subject. The system and method utilizes different Internal Personalized Explorer (IPE) stimuli subliminally exposed to the subject on a visual display. Following exposure, the subject performs a target-specific cognitive task and a related behavior (e.g., deciding whether a briefly displayed string of letters is a word or not, and pressing a button to indicate the decision). The decision reaction lime for the behavior is recorded in a computer database. The reaction times are interpreted quantitatively to detect the relative intensity of the specific cognitive-emotional mental state in the subject. A reaction time for a specific individual IPE that is shorter than the mean reaction time for an IPE that does not evoke the emotional state indicates that the specific individual IPE did evoke the emotional state in the subject.2011-02-03
20110027765METHODS FOR TREATING SOCIAL DISORDERS - Systems and methods for treating patients with an anxiety disorder are disclosed. The systems comprise a screen for displaying sets of stimuli, a computer to control the display of stimuli onto the screen during at least one treatment session and the ability for the patient to interact with the screen in response to the displayed stimuli. The interaction of the patient with the system during the treatment session is capable of treating patient anxiety associated with an anxiety disorder, such as social anxiety. Also provided are computer programs capable of being used in the systems and methods of the present invention for treating anxiety.2011-02-03
20110027766Unified Vision Testing And/Or Training - Unified vision testing and/or training kiosk may utilize display devices and input devices to administer a number of visual testing and/or training tasks to an individual. One or more display devices may provide desired resolution, geometry, and/or touch sensitivity. One or more input devices may receive inputs of different types from different positions relative to a display device. Methods of visual testing and/or training may utilize the one or more display devices, one or more input devices, and/or other types of equipment to evaluate and/or improve the visual abilities of an individual.2011-02-03
20110027767Anthropomorphic mannequin - The anthropomorphic mannequin includes a skeletal portion made from relatively hard, rigid material, organ and muscle portions made from softer, compressible, and extensible materials, and a skin portion made from compressible and extensible materials. Extensible materials are attached to a core structure and distributed in middle and outer layers of the anthropomorphic model and connect skeletal members to simulate the movement and feel of soft tissue and muscles across the joints. An elastic cord connected across the joints produces a life-like feel to the touch. The anthropomorphic mannequin allows flexion, extension, side bending, and rotation at appropriate joints to simulate human joint movement. The mannequin provides a training dummy for those who have to physically manipulate a human patient.2011-02-03
20110027768APPARATUS AND METHODS FOR RESOLVING CONFLICT - Apparatus and methods for resolving a decision conflict without the assistance of moderator are described herein. A representative method comprises providing a party to the decision conflict with a token that represents the first option to resolve the next decision conflict. When two parties are faced with a decision having only one reasonable outcome and the parties want different outcomes, the party with the token can either make the decision and pass the token to the other party, or the party with the token can retain the token and allow the other party to make the decision. In some cases, there is no limit to the number of times the token can be passed each day or how long a party can retain the token. In some cases, the methods and apparatus are modified to allow more than two parties to resolve a decision conflict without moderator intervention.2011-02-03
20110027769Automatic Essay Scoring System - A method of grading an essay using an automated essay scoring system is provided. The method comprises the steps of deriving a set of predetermined features from the essay, wherein the predetermined feature set comprises one or more features that are independent from the test prompt, scoring the feature set with a scoring equation, wherein a multiple regression analysis with graded essay data produces weights for the scoring equation, generating a raw score for the essay; and processing the raw score for the essay into a score category based on an adaptive cutoff algorithm. Also provided is a method of generating a model in which to grade essays, wherein the data used to generate the model is independent from the test prompt or essay topic.2011-02-03
20110027770READER DEVICES AND RELATED HOUSINGS AND ACCESSORIES AND METHODS OF USING SAME - A system for presenting multimedia content, comprising: a reader device; at least one of a reader device housing or reader device accessory removably attached to the reader device; and, at least one multimedia content enhanced object with at least one multimedia content indicator; wherein the reader device adapts its operation based on an identification of the at least one reader device housing or reader device accessory removably attached thereto.2011-02-03
20110027771METHODS AND COMPOSITIONS FOR CELL STABILIZATION - Fragile cells have value for use in diagnosing many types of conditions. There is a need for compositions that stabilize fragile cells. The stabilization compositions of the provided invention allow for the stabilization, enrichment, and analysis of fragile cells, including fetal cells, circulating tumor cells, and stem cells.2011-02-03
20110027772Antigen Detection Kit and Method - An antigen detection kit and an antigen detection method using the same are provided. The antigen detection kit comprises a capture antibody, a detection antibody bound to a single stranded DNA oligonucleotide, a single stranded RNA oligonucleotide complementary sequence to the DNA oligonucleotide, and an RNase.2011-02-03
20110027773MASS SPECTROMETRIC METHODS FOR DETECTING MUTATIONS IN A TARGET NUCLEIC ACID - Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. In some embodiments, a process comprises: amplifying a nucleic acid from a biological sample; ionizing and volatilizing the amplified product; analyzing the product by mass spectrometry to determine an observed molecular mass of the product; and comparing the observed molecular mass of the product to a calculated molecular mass of at least one nucleic acid having a known sequence, wherein the calculated molecular mass of the at least one nucleic acid having a known sequence is derived from the base composition of the at least one nucleic acid having a known sequence; whereby the presence or absence of the target nucleic acid is detected based on the comparison.2011-02-03
20110027774HIGHLY SENSITIVE METHOD FOR DETECTION OF VIRAL HIV DNA REMAINING AFTER ANTIRETROVIRAL THERAPY OF AIDS PATIENTS - Methods for detecting polynucleotides, especially the DNA replicated from samples obtained from subjects infected with pathogenic viruses such as human immunodefiency virus, by detecting electromagnetic signals (“EMS”) emitted by such polynucleotides, and methods for improving the sensitivity of the polymerase chain reaction (“PCR”).2011-02-03
20110027775DETECTION OF INFLUENZA VIRUS - A change in strain of flu and consequently pandemic potential can be determined by assessing the presence or absence of a PL motif. The 2009 swine flu illustrates the utility of such a test. The swine flu is a subtype H1N1 influenza A. Swine flu differs from the vast majority of influenza H1N1 subtype strains from 1981-2008 or H3N2 strains from 1985 to the present in that its NS1 protein lacks a PL motif. PDZ polypeptides can be used to identify such strains and distinguish them from strains in which PL motifs are present.2011-02-03
20110027776KITS AND METHODS FOR ASSESSING ANTIOXIDANT REQUIREMENT OF A HUMAN - The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2011-02-03
20110027777METHOD FOR PERFORMING PROGNOSIS FOR HIGH-RISK BREAST CANCER PATIENTS USING TOP2A GENE ABERRATIONS - A first exemplary method for performing a prognosis for a breast cancer patient, comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre determined Hazard Ratio corresponding to the determined status. A second such exemplary method comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre-determined Kaplan-Meier plot corresponding to the determined status.2011-02-03
20110027778COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR IMPROVED DETECTION OF HUMAN PAPILLOMAVIRUS GENOTYPES - The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.2011-02-03
20110027779POLYNUCLEOTIDE PRIMERS - A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.2011-02-03
20110027780AMPLIFICATION METHODS - Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.2011-02-03
20110027781System for Autonomous Monitoring of Bioagents - An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.2011-02-03
20110027782PROBES AND METHODS FOR DETECTION OF PATHOGENS AND ANTIBIOTIC RESISTANCE - Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specimen is contacted with a capture probe immobilized on a substrate, wherein the capture probe comprises an oligonucleotide that specifically hybridizes with a first target nucleic acid sequence region of ribosomal RNA. The lysate is in contact with a detector probe that comprises a detectably labeled oligonucleotide that specifically hybridizes with a second target nucleic acid sequence region of ribosomal RNA. The presence or absence of labeled oligonucleotide complexed with the substrate is determined. Detection of labeled oligonucleotide complexed with the substrate is indicative of the presence of pathogen. Performing the method in the presence and absence of an antibiotic permits detection of antibiotic resistance.2011-02-03
20110027783EXO1 Promotor Polymorphism Associated with Exceptional Life Expectancy in Humans - The invention relates to an exonuclease 1 (EXO1) promoter polymorphism associated with exceptional life expectancy in humans. More specifically, the invention relates to the promoter region of EXO1 where the gene has been found to be mutated. Moreover, the invention relates to a gene regulation mechanism involving transcription factor E47 as a transcriptional repressor of EXO1.2011-02-03
20110027784Novel Primers for Identification of Astrocytoma, Its Grades and Glioblastoma Prognosis - The present invention relates to novel primers for identification of astrocytoma, it's grades and glioblastoma prognosis. Further, disclosed is a method of diagnosing the presence of different grades of diffuse astrocytoma and glioblastoma, in a human subject, which involves detection of the expression levels of said genes in tumor tissue samples in comparison to normal brain. Also disclosed is a method of distinguishing between the two types of Glioblastoma—the progressive and de novo types. Also disclosed is a method of prognosis of glioblastoma based on the expression of the gene PBEF1, wherein the higher level of expression of the gene in the tumor sample, indicates poorer survival of the human subject. The disclosed compositions are useful, for example, in the diagnosis, prevention, treatment and/or prognosis of astrocytoma. The invention further provides kits for the detection and prognosis of the said diseases.2011-02-03
20110027785METHOD FOR DETERMINING SUSCEPTIBILITY OF INDIVIDUALS TO POLYPHENOLS - Consumption of high energy diets, lack of physical activity and sleep curtailment have all been linked to the development of type II diabetes and cardiovascular disease. Studies have also shown how powerful diet and lifestyle modification can be for preventing disease. However not everyone responds to lifestyle change in the same way. This is because genetic factors can modify biological response to environmental challenge.2011-02-03
20110027786PRIMERS FOR NUCLEIC ACID EXTENSION OR AMPLIFICATION REACTIONS - Disclosed are methods and compositions for use in nucleic acid amplification or extension reactions.2011-02-03
20110027787METHODS AND SYSTEMS FOR IDENTIFYING AND ISOLATING STEM CELLS AND FOR OBSERVING MITOCHONDRIAL STRUCTURE AND DISTRIBUTION IN LIVING CELLS - Methods and systems for a) identifying and isolating stem cells, b) assessing mitochondrial distribution and structure in living cells and c) performing fluorescence microscopy on living cells while the cells remain within a condition-controlled cell culture chamber.2011-02-03
20110027788REAGENT AND KIT FOR CLASSIFYING AND COUNTING LEUKOCYTES, THE PREPARATION THEREOF, AND PROCESS FOR CLASSIFYING AND COUNTING LEUKOCYTES - A reagent for classifying and counting leukocytes containing (1) a cyanine fluorescent dye; and (2) a glycoside compound; a reagent kit containing the reagent for classifying and counting leukocytes as well as its preparation process; and a process for classifying and counting blood cells using the reagent or kit are provided. Using the reagent, kit and/or process provided, leukocytes can be classified and counted in four groups with a high degree of differentiation and a better classification among each subpopulation of leukocytes, especially in that it successfully addresses the indistinct classification between lymphocytes and monocytes and between the eosinophils and neutrophils in a scattergram.2011-02-03
20110027789METHODS FOR PRESERVATION OF GENOMIC DNA SEQUENCE COMPLEXITY - The present invention relates to methods and kits for preserving genomic DNA sequence complexity within chemically and/or enzymatically converted DNA by an enzyme or series of enzymes that adds a methyl group to a cytosine outside of CpG dinucleotide sequences of genomic DNA. Further, the present invention relates to methylation analysis of the genomic DNA.2011-02-03
20110027790METHODS OF EQUALIZING REPRESENTATION LEVELS OF NUCLEIC ACID TARGETS - The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method 1, starting concentrations of probes are adjusted. In Method 2, target-specific probes are “binned,” i.e., several subsets of probes are selected based on similar representation levels. Thereafter, each subset of corresponding targets is extracted, with or without amplification, using a separate portion of the sample (i.e., separate vessels).2011-02-03
20110027791METHOD FOR GENERATING SINGLE-STRANDED DNA MOLECULES REPRESENTATIVE OF A DNA SAMPLE - A method for generating a population of single stranded DNA molecules representative of a DNA sample, including digesting the DNA sample with a Type I restriction endonuclease; subjecting the DNA fragments to melt conditions to produce a melt-generated mixture of forward and reverse single stranded DNA fragments; contacting the mixture of forward and reverse single strand DNA fragments with a solid support having immobilized thereon the complement of either the forward or reverse strand, wherein the solid phase hybridizations are favored over self-annealing of the melt-generated single stranded DNA molecules; and releasing the captured forward or reverse single strand DNA fragments from the complement immobilized to the solid support to generate a population of single stranded DNA molecules representative of the DNA sample.2011-02-03
20110027792ASSAY FOR MYCOBACTERIUM AVIUM/INTRACELLULARE NUCLEIC ACID - Disclosed is a method for determining the presence of 2011-02-03
20110027793KIT FOR MEASURING IN VIVO MUTATION FREQUENCY AT AN ENDOGENOUS GENE LOCUS - The present invention relates a method for the enumeration of in vivo gene mutation. The method utilizes differential staining of GPI-anchor deficient erythrocyte populations to distinguish between wild-type and pig-a gene mutants. Quantitative analyses can be conducted on erythrocytes and/or reticulocytes, and is based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of mutant erythrocytes or reticulocytes relative to the number of total erythrocytes or reticulocytes can be used to assess the DNA-damaging potential of an exogenous chemical agent, the DNA-damaging potential of an exogenous physical agent, the effects of an exogenous agent which can modify endogenously-induced DNA damage, and the effects of an exogenous agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.2011-02-03
20110027794Method for Synthesizing Nucleic Acids, and Application Thereof - The invention relates to a method for synthesizing a nucleic acid containing modified nucleotides. The method encompasses the following steps: a matrix strand is provided; —a primer which at least partially hybridizes on the matrix strand is provided; —nucleoside triphosphates, at least some of which are modified nucleoside triphosphates, are provided; —a polymerase activity is supplied; and—the matrix strand, the primer, and the nucleoside triphosphates are incubated so as to synthesize a nucleic acid that is substantially complementary to the matrix strand. The polymerase activity can be a reverse transcriptase activity.2011-02-03
20110027795CELL PROCESSING AND/OR ENRICHMENT METHODS - The present invention relates to methods of processing and/or enriching cells from a pregnant female. More particularly the invention provides methods for processing and/or enriching fetal cells from a pregnant female. The enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.2011-02-03
20110027796METHOD FOR DETECTING LUNG CANCER USING LUNG CANCER-SPECIFIC METHYLATION MARKER GENE - The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect methylation of PCDHGA12 gene whose 5′UTR or exon 1 region is specifically methylated in lung cancer cells, and to a method of detecting lung cancer and the stage of its progression using the biomarker. The diagnostic kit according to the present invention makes it possible to diagnose lung cancer at an early stage in an accurate and rapid manner compared to conventional methods and can be used for prognosis and monitoring of lung cancer and the stage of its progression.2011-02-03
20110027797Method for the Diagnosis of Higher- and Lower-Grade Astrocytoma Using Biomarkers and Diagnostic Kit Thereof - Disclosed is a method of diagnosing the presence of higher grade astrocytoma/glioblastoma (GBM) or lower-grade grade astrocytoma (DA or AA) in a human subject using secreted or plasma membrane associated biomarkers, which involves the detection of the expression levels of said genes, alone or in combination, in either tumor tissue samples or body fluids and a diagnostic kit thereof.2011-02-03
20110027798Hybridization Quantitation Method for Modified Micro-RNA and -DNA Based Oligonucleotides - Described herein is a method for the qualitative and/or quantitative determination of an analyte in a test sample which includes base pairing at least one oligonucleotide to a capture template having an overhang; and, hybridizing with a detection probe.2011-02-03
20110027799KIT AND METHOD FOR DETERMINING WHETHER OR NOT UNMETHYLATED CYTOSINE CONVERSION TREATMENT IS PROPERLY CARRIED OUT AND METHOD FOR ANALYZING METHYLATED DNA USING THE SAME - Success or failure of unmethylated cytosine conversion treatment is determined by using a first primer set comprising plural primers that hybridize with a nucleic acid comprising a nucleotide sequence not containing cytosine in the nucleotide sequence of biological DNA that is subject to an unmethylated cytosine conversion treatment and a second primer set comprising plural primers that hybridize with a nucleic acid comprising a nucleotide sequence in which cytosine in a nucleotide sequence containing cytosine and not containing a CpG site is converted into a base other than cytosine, in the nucleotide sequence of biological DNA.2011-02-03
20110027800Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings - The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.2011-02-03
20110027801EphA KINASE CANCER DIAGNOSTIC - A method of detecting malignant progression of neoplastic cells in an animal includes obtaining a sample of neoplastic cells from the animal, determining a level of S897-EphA2 phosphorylation in the neoplastic cells of the samplem, and comparing the determined level of S897-EphA2 phosphorylation in the sample to a control value, wherein an increased level of S897-EphA2 phosphorylation compared to the control value is indicative of malignant progression of the neoplastic cell in the animal.2011-02-03
20110027802Methods and Kits for Separation and Detection of Proteins in Biological Samples - Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells and in the early clinical diagnosis of myocardial damage by detection of myofilament proteins in serum of a subject.2011-02-03
20110027803Compositions and Methods for Maintenance of Fluid Conducting and Containment Systems - Latently detectable small molecules, or ‘labels’, used for monitoring of treatment substances in fluid conducting and containment systems. A composition comprising the treatment substance and the label, a method of manufacturing the composition, a method and kit for use in monitoring the treatment substances in a fluid conducting and containment system, and a method for treating such a system using the composition are also disclosed.2011-02-03
20110027804IMMUNE SYSTEM MODELING DEVICES AND METHODS - Devices and methods are provided for detecting an immune reaction to a test agent using an immune modeling system comprising a barrier component configured to culture a biological barrier, an immune component configured to culture immune cells, and one or more inter-component microfluidic connections between the barrier component and the immune component. The system provides for culturing a biological barrier in the barrier component of the system, culturing immune cells in the immune component of the system, applying the test agent to the biological barrier, and monitoring the immune cells to detect an immune reaction to the test agent.2011-02-03
20110027805ACPL-RELATED ASSAYS - The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.2011-02-03
20110027806FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors.2011-02-03
20110027807PROTEIN SPECIFIC TO PANCREATIC BETA CELLS IN ISLETS OF LANGERHANS AND APPLICATIONS THEREOF - The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for screening medicine acting on diabetes and hyperinsulinism.2011-02-03
20110027808METHODS AND KITS FOR DETECTING TUMOR-SPECIFIC FUSION PROTEINS - The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and hematology. Specifically, the invention relates to improved flow cytometric techniques, and kits related thereto, for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor cells.2011-02-03
20110027809METHOD FOR EVALUATION OF DEGREE OF MALIGNANCY OF TUMOR CELL - Disclosed is a method for evaluating the degree of malignancy of a tumor cell, which comprises: preparing a cell membrane fraction containing a receptor tyrosine kinase (RTK) from a sample containing the tumor cell; measuring the enzymatic activity of RTK in the cell membrane fraction in both the presence and absence of an RTK activity inhibitor; and comparing the results obtained in the presence of the RTK activity inhibitor with those obtained in the absence of the RTK activity inhibitor.2011-02-03
20110027810CHIMERIC RECOMBINANT ANTIGENS OF TOXOPLASMA GONDII - The invention described herein relates to a method for combining antigen fragments of 2011-02-03
20110027811ASSAY SYSTEM FOR THE ASSESSMENT OF ONCOGENICITY, TUMOR PROGRESSION, AND TREATMENT EFFICACY - Systems and kits are provided which are capable of determining the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment. Such systems and kits utilize assays to examine the levels of apoptotic markers, angiogenesis markers, immunomodulation markers, and cell cycle markers and can compare samples from a patient taken at different times to determine the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment. Methods for determining the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment with such systems and kits are also provided.2011-02-03
20110027812ASSAY FOR ANTIBODIES TO MYCOBACTERIUM PARATUBERCULOSIS - A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response to the paratuberculosis-specific antigen. The antigen may be obtained from a novel 2011-02-03
20110027813Compositions for Binding to Assay Substrata and Methods of Using - Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for example, lyotropic liquid and/or liquid crystalline materials) and may contain macromolecular standards, markers or capture compounds. The compositions are capable of binding to assay substrata such as that of chips that are employed for MALDI and SELDI mass spectroscopy analyses and plates that are used for ELISA type assays.2011-02-03
20110027814BRCA1 function-based cellular assays - Assays using binding studies involving function of BRCA1a protein have use for diagnosis and for evaluation of possible tumorogenicity of agents, particularly estrogenic agents. The assays do not rely on use of a probe for only specific sequences, but on effects of known and unknown or not previously studied sequences (consequence of genetic changes) or posttranslational modification of BRCA1 proteins (as a consequence of epigenetic changes) as seen in hereditary and sporadic cancers.2011-02-03
20110027815METHOD OF DETECTING ISOLEVUGLANDIN PHOSPHOLIPID ADDUCTS - A method of measuring isolevuglandin and/or levuglandin adducts associated with oxidative injury in a subject includes obtaining a bodily sample from a subject suspected of including isolevuglandin and/or levuglandin phospholipid adducts, hydrolyzing isolevuglandin and/or levuglandin phospholipid adducts from the sample with an enzyme that forms isolevuglandin and/or levuglandin phospholipid derivatives, and determining the amount of isolevuglandin and/or levuglandin phospholipid derivatives by mass spectrometry.2011-02-03
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