05th week of 2012 patent applcation highlights part 56 |
Patent application number | Title | Published |
20120029141 | AQUEOUS COATING COMPOSITION COMPRISING SPHERICAL SILICA PARTICLES AND METHOD OF MAKING AND USING THE SAME - Compositions include a polymer and silica nanoparticles dispersed in an aqueous continuous liquid phase. The polymer is a water-soluble copolymer of acrylic acid and an acrylamide, or a salt of the same. Methods of making and using the compositions to coat a substrate are also disclosed. | 2012-02-02 |
20120029142 | Heterogeneous Vinyl Acetate Based Copolymers as Binder for Paints - The present invention describes a method for the manufacturing of a multi-stage polymer by the following steps:
| 2012-02-02 |
20120029143 | SILANE COATING MATERIAL AND A PROCESS TO PRODUCE SILANE COATING - A process to produce a silane coating includes charging one or several silanes, which are not or only minimally pre-condensed, with a reactant and the thus created coating material is applied onto a substrate and then hardened. Surprisingly it has been shown that, through the reaction involving higher-molecular and only slightly pre-cross-linked silanes with a suitable reactant, a new class of coating materials can be created. The approach is advantageous insofar as restrictions with respect to pot time no longer exist and, in addition, better features of the coating material are obtained, especially a high scratch-resistance. | 2012-02-02 |
20120029144 | HIGH-FUNCTIONALITY POLYISOCYANATES CONTAINING URETHANE GROUPS - The present invention relates to new, urethane-group-containing polyisocyanates based on aliphatic and/or cycloaliphatic diisocyanates, and to their use. | 2012-02-02 |
20120029145 | EXTRUSION OF POLYURETHANE COMPOSITE MATERIALS - A polyurethane composite material is described herein. The composite material may comprise a product of a reaction mixture between two or more polyols and an isocyanate, and may contain high levels of inorganic particulate material. Methods of preparing the composite material by forcing the material through a hole are also described. These composite materials may be useful in products such as synthetic building materials. | 2012-02-02 |
20120029146 | AQUEOUS POLYURETHANE RESIN DISPERSION - Provided is an aqueous polyurethane resin dispersion having a good film-forming property, and excellent mechanical properties and water resistance. The present invention is an aqueous polyurethane resin dispersion comprising water and a polyurethane resin (U) and satisfying all of the following conditions (1) to (6): (1) a urethane group content in the polyurethane resin (U) is 0.5 to 5.0 mmol/g, based on weight of the polyurethane resin (U); (2) a terminal amino group content in the polyurethane resin (U) is not more than 0.35 mmol/g, based on the weight of the polyurethane resin (U); (3) a number average molecular weight (Mn) of the polyurethane resin (U) is 10,000 to 1,000,000; (4) a ratio (Mw/Mn) of a weight average molecular weight (Mw) to the number average molecular weight (Mn) of the polyurethane resin (U) is 1.5 to 3.5; (5) a melting temperature of the polyurethane resin (U) is 70 to 280° C.; and (6) a volume average particle diameter (Dv) of the polyurethane resin (U) is 0.01 to 1 μm. | 2012-02-02 |
20120029147 | CURABLE FLUORINE-CONTAINING POLYETHER COMPOSITION - Disclosed is a curable fluorine-containing polyether composition comprising (A) 100 parts by weight of a fluorine-containing polyether compound of the formula: | 2012-02-02 |
20120029148 | POLYESTER NANOCOMPOSITES - Polyester nanocomposite compositions contain silica nanoparticles that have been subjected to surface treatment with novel trialkoxysilane compositions. The novel silane compositions are prepared by reacting a 3-isocyanatopropyl trialkoxysilane with 1,3-propanediol or certain polyether diols. The silica nanoparticles exhibit improved dispersion in the polyester. This leads to haze reduction and improvements in mechanical properties. | 2012-02-02 |
20120029149 | POLYGLYCEROL ALDEHYDES - Novel polyglycerol aldehyde polymers are described. The polymers comprise glycerol monomers connected by ether linkages and have 3 to about 170 aldehyde groups per molecule. The polyglycerol aldehydes may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions. | 2012-02-02 |
20120029150 | CROSSLINKED FIBERS AND METHOD OF MAKING SAME BY EXTRUSION - The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production. | 2012-02-02 |
20120029151 | CURABLE POLYORGANOSILOXANE COMPOSITION - A curable polyorganosiloxane composition which has an (A) alkenyl group-containing polyorganosiloxane, a (B) polyalkylhydrogensiloxane and (C) a platinum group metal compound. The (A) alkenyl group-containing polyorganosiloxane which includes (A1) branched polyorganosiloxane comprising an SiO | 2012-02-02 |
20120029152 | FLUORINE-CONTAINING ELASTOMER MIXTURE, METHOD FOR PRODUCING SAME, COMPOSITION FOR VULCANIZING PEROXIDE, AND MOLDED ARTICLE - A fluoroelastomer mixture, including: a peroxide-vulcanizable fluoroelastomer (A) containing an iodine atom; and a peroxide-vulcanizable fluoroelastomer (B) containing an iodine atom. The fluoroelastomer (A) is a copolymer (a1) consisting of 50 to 85 mol % of a vinylidene fluoride unit and 15 to 50 mol % of a perfluoro(alkyl vinyl ether) unit, or a copolymer (a2) consisting of 45 to 85 mol % of a vinylidene fluoride unit, 1 to 30 mol % of a tetrafluoroethylene unit, and 14 to 30 mol % of a perfluoro(alkyl vinyl ether) unit. Further the fluoroelastomer (B) has a fluorine content of 70.0% or more. Also disclosed is a composition for peroxide vulcanization containing the above fluoroelastomer composition (i), a polyfunctional unsaturated compound (ii) and a peroxide (iii), as well as a method for producing the fluoroelastomer mixture. | 2012-02-02 |
20120029153 | ADHESIVE AND MANUFACTURING METHOD THEREOF - An adhesive and a manufacture method thereof are provided. The adhesive is made by crosslinking a first polymer with a second polymer. The glass transition temperature of the first polymer is higher than the glass transition temperature of the second polymer. The first polymer and the second polymer are miscible in each other. | 2012-02-02 |
20120029154 | GRAFTING METHOD TO IMPROVE CHROMATOGRAPHY MEDIA PERFORMANCE - The invention also relates to improvements in the method of grafting polymeric ligands onto substrates used in protein separations, resulting in substrates having improved protein binding capacity, improved purification process operating windows and resin selectivity, and relating to making and using the same. | 2012-02-02 |
20120029155 | Fluorescent Methods and Materials for Directed Biomarker Signal Amplification - Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule. | 2012-02-02 |
20120029156 | Epoxy Curing Compositions and Methods - Disclosed are accelerator/curing agent compositions for epoxy resins, comprising (a) at least one aromatic or alicyclic compound containing at least two amine moieties, such amine-containing aromatic or alicyclic compound(s) preferably having from 3 to 5 amine hydrogens per compound and preferably two primary amines per compound, (b) at least one aliphatic compound containing at least two amine moieties, such compound(s) preferably having from 2 to 4 amine hydrogens per compound and one primary and one secondary amine per compound, and (c) at least one non-reactive catalytic compound, preferably having no amine hydrogens. The compositions are useful as drop-in replacements for N-aminoethylpiperazine. | 2012-02-02 |
20120029157 | MODIFIED SILOXANE POLYMER COMPOSITION, ENCAPSULANT OBTAINED FROM THE MODIFIED SILOXANE POLYMER COMPOSITION, AND ELECTRONIC DEVICE INCLUDING THE ENCAPSULANT - A modified siloxane polymer composition, an encapsulant, and an electronic device, the modified siloxane polymer including a modified siloxane polymer and a reticular siloxane polymer, the modified siloxane polymer including a cyclic siloxane moiety having at least two Si—O bonds with a cyclic structure, a substituted or unsubstituted linear siloxane moiety linked to Si of the cyclic siloxane moiety with a C2 to C10 alkylene group therebetween, and double bonds at its terminal ends. | 2012-02-02 |
20120029158 | METHOD FOR PREPARING CYCLIC OLEFIN ADDITION POLYMER OF HIGH GAS PERMEABILITY - A method for preparing a cyclic olefin addition polymer of high gas permeability, which method including subjecting a specific type of cyclic olefin-functional siloxane and a mixture thereof with a specific type of cyclic olefin compound to addition polymerization in the presence of a multi-component catalyst containing (A) a zero-valent palladium compound, (B) an ionic boron compound, and (C) a phosphine compound having a substituent group selected from an alkyl group having 3 to 6 carbon atoms, a cycloalkyl group and an aryl group, to obtain a cyclic olefin addition polymer of high gas permeability wherein a ratio of the structural units derived from the cyclic olefin-functional siloxane is at 10 to 100 mole % of the addition polymer and a number average molecular weight (Mn) ranges from 100,000 to 2,000,000. | 2012-02-02 |
20120029159 | POLYDENTATE HETEROATOM LIGAND CONTAINING METAL COMPLEXES, CATALYSTS AND METHODS OF MAKING AND USING THE SAME - Metal complexes comprising certain polydentate heteroatom containing ligands, catalysts, and coordination polymerization processes employing the same are suitably employed to prepare polymers having desirable physical properties. | 2012-02-02 |
20120029160 | SEQUENTIALLY CROSS-LINKED POLYETHYLENE - A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. | 2012-02-02 |
20120029161 | COMPOSITION FOR THERMOPLASTIC SILICONE RESIN - The present invention relates to a composition for a thermoplastic silicone resin, the composition including: at least one imide compound selected from the group consisting of compounds represented by formula (I) in which X represents a hydrogen atom or a monovalent hydrocarbon group and compounds represented by formula (II) in which Y represents a divalent hydrocarbon group; an organohydrogensiloxane; and a hydrosilylation catalyst. | 2012-02-02 |
20120029162 | CARBON NANOTUBES COMPRISING HYDROXY GROUPS, METHOD FOR THE PRODUCTION THEREOF AND POLYURETHANE POLYMERS COMPRISING SAID CARBON NANOTUBES - The invention relates to carbon nanotubes comprising hydroxy groups, wherein the surface thereof comprises hydroxy alkyl ester groups covalently bound thereon, chosen from the group according to the general formula (1) and/or the general formula (2), wherein (CNT) stands for the surface of the carbon nanotube and R1 and R2 are independently from each other hydrocarbon, an alkyl radical or an aryl radical. The invention further relates to a method for the production thereof by means of reaction of carbon acid groups of the carbon nanotubes with an epoxy, furthermore a polyurethane polymer, wherein said carbon nanotubes are covalently bound, a method for producing a polymer of said kind and use of the carbon nanotubes for producing polymers. | 2012-02-02 |
20120029163 | METHOD OF PREPARING A HEAT-RESISTANT POLYAMIDE - The present invention relates to a method of prepairing a heat-resistant polyamide by carrying out condensation polymerisation with a monomer mixture including a diester compound and a diamine compound. The present invention provides an economical method of prepairing a heat-resistant polyamide in that a monomer, a raw material, is simply and chiefly prepared, and the polymerizing reaction time is short because it does not need solvent separately. | 2012-02-02 |
20120029164 | ESTER GROUP-CONTAINING TETRACARBOXYLIC ACID DIANHYDRIDE, POLYESTER POLYIMIDE PRECURSOR, POLYESTERIMIDE, AND METHODS FOR PRODUCING SAME - Disclosed is a polyesterimide having a repeating unit expressed by the formula below, and also provides the manufacturing methods thereof: | 2012-02-02 |
20120029165 | Methods and Compositions Involving Whey Protein Isolates - The present invention concerns methods of isolating milk proteins. Methods of the invention include charged ultrafiltration processes that use variations in pH to further separate protein species. | 2012-02-02 |
20120029166 | LINKERS AND CO-COUPLING AGENTS FOR OPTIMIZATION OF OLIGONUCLEOTIDE SYNTHESIS AND PURIFICATION ON SOLID SUPPORTS - A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications. | 2012-02-02 |
20120029167 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND - A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods. | 2012-02-02 |
20120029168 | METHOD FOR AMELIORATING PAIN BY MODIFICATION OF NMDA RECEPTORS THROUGH INHIBITION OF SRC - The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject by inhibition of the interaction of the unique domain of the tyrosine kinase Src enzyme and the NMDA receptor complex. | 2012-02-02 |
20120029169 | METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS - Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught. Methods for producing and purifying these structures for the development of small molecule and immunotherapeutics as well as antibodies for biomarkers of neurodegenerative diseases are taught. | 2012-02-02 |
20120029170 | METHODS OF PROTEIN EXTRACTION FROM SUBSTANTIALLY INTACT ALGAL CELLS - Methods for selective extraction and fractionation of algal proteins from an algal biomass or algal culture are disclosed. A method of selective removal of products from an algal biomass provides for single and multistep extraction processes which allow for efficient separation of algal proteins. These proteins can be used as renewable sources of proteins for animal feedstocks and human food. Further, lipids remaining in the algal biomass after extraction of proteins can be used to generate renewable fuels. | 2012-02-02 |
20120029171 | Method of Producing a Plurality of Isolated Antibodies to a Plurality of Cognate Antigens - The present invention relates to a method for producing high affinity antibodies that are antigen-specific. The method involves binding a plurality of antibody-producing B-cells from a mammal to a plurality of cognate antigens; sorting the bound antibody-producing B-cell and cognate antigen; amplifying nucleic acid sequences encoding each antibody, or fragment thereof, from the B-cells; and expressing the each antibody in a protein expression system. Antibodies produced in this manner are useful in diagnostic and therapeutic applications. | 2012-02-02 |
20120029172 | Humanized GM-CSF antibodies - Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as methods for manufacturing these, are also disclosed. | 2012-02-02 |
20120029173 | ATTENUATED SALMONELLA ENTERICA SEROVAR PARATYPHI A AND USES THEREOF - The present invention is drawn to a live, attenuated | 2012-02-02 |
20120029174 | METHODS FOR PRODUCING SUBSTANTIALLY HOMOGENEOUS HYBRID OR COMPLEX N-GLYCANS IN METHYLOTROPHIC YEASTS - The present invention provides methods for effectively and efficiently converting methylotrophic yeast's heterogeneous high mannose-type N-glycosylation to mammalian-type N-glycosylation by disruption of an endogenous glycosyltransferase gene (OCH1) and step-wise introduction of heterologous glycosidase and glycosyltransferase activities. Each engineering step includes a number of stages: transformation with an appropriate vector, cultivation of a number of transformants, performance of sugar analysis and heterologous protein expression analysis, and selection of a desirable clone. The selected clone is then subjected to the next engineering step. | 2012-02-02 |
20120029175 | Protein Complex and Process for Producing the Same - A process for producing an embedded protein antigen, comprising embedding a protein antigen having two or more cysteine residues in a molecule thereof, into a hydrophobized polysaccharid. Prior to or after the embedding of the protein antigen, the protein antigen is purified. There are provided an embedded protein antigen and a process for producing the same, which can advantageously purify the protein antigen, while suppressing the denaturation of the protein antigen as completely as possible. | 2012-02-02 |
20120029176 | Chromatography Media And Method - Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs). | 2012-02-02 |
20120029177 | HETEROCYCLE-AMINO ACID DERIVATIVES FOR TARGETING CANCER TISSUE AND RADIOACTIVE OR NON-RADIOACTIVE LABELED COMPOUNDS THEREOF - The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparative kits of the composition for targeting cancer cells. | 2012-02-02 |
20120029178 | High-Purity Fractionation of Anthocyanins from Fruits and Vegetables - Disclosed is a method for separating anthocyanins depleted in phenolic mixture content from fruits or vegetables feedstock containing anthocyanins and phenolic mixtures. The first step is to contact the feedstock with a cation-exchange resin at low pH for a time period effective for the resin to selectively bind with the anthocyanins. Next, the non-bound phenolic mixture is separated from the resin for recovery. The bound resin is subjected to solvent wash to release the anthocyanins for recovery. | 2012-02-02 |
20120029179 | PROCESS FOR THE SYNTHESIS OF CLEISTANTHIN - The present invention relates to a process for preparing compound of formula (I) that is Cleistanthin A. The process comprises the steps of reacting compound of formula (II) with compound of formula (III) in the presence of a first solvent, quarternary ammonium salt and first alkali to form compound of formula (IV). The compound of formula (IV) is further treated with a second solvent and a second alkali to form compound of formula (I). The present invention also relates to the preparation of salt of compound of formula (IV) that is Cleistanthin A acetate. | 2012-02-02 |
20120029180 | A H+-GATED ION CHANNEL - The invention relates to an isolated or recombinant Na | 2012-02-02 |
20120029181 | SYNTHESIS OF 5-AZACYTIDINE - The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: | 2012-02-02 |
20120029182 | NOVEL STABLE CRYSTAL OF 1-(2'-CYANO-2'-DEOXY-BETA-D-ARABINOFURANOSYL)CYTOSINE MONOHYDROCHLORIDE - Disclosed is a stable crystal of 1-(2′-cyano-2′-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride. There is provided a crystal of 1-(2′-cyano-2′-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride having characteristic peaks at 13.7°, 15.7°, 16.0°, 18.6°, 20.3°, and 22.7° as diffraction angles (2θ±0.1°) measured by powder X-ray diffraction, and having a melting point of 192° C. to 197° C. | 2012-02-02 |
20120029183 | SULFATED C-GLYCOSIDE, METHOD FOR ISOLATING SAME AND METHOD FOR SYNTHESIZING SAME - Provided are a sulfated C-glycoside which is a novel compound serving as a precursor of chafuroside and chafuroside analogs; a method for efficiently producing the sulfated C-glycoside; and a method for efficiently producing chafuroside and chafuroside analogs using said sulfated C-glycoside. A sulfated C-glycoside represented by general formula (A1) or (B1) [wherein R | 2012-02-02 |
20120029184 | METHODS OF AND SYSTEMS FOR ISOLATING CAROTENOIDS AND OMEGA-3 RICH OIL PRODUCTS FROM ALGAE - A method of isolating nutraceuticals products from algae is provided. A method of isolating carotenoids and omega-3 rich oil from algae includes dewatering substantially intact algal cells to make an algal biomass and adding a first ethanol fraction to the algal biomass. The method also includes separating a first substantially solid biomass fraction from a first substantially liquid fraction comprising proteins and combining the first substantially solid biomass fraction with a second ethanol fraction. The method further includes separating a second substantially solid biomass fraction from a second substantially liquid fraction comprising polar lipids and combining the second substantially solid biomass fraction with a third ethanol solvent fraction. The method also includes separating a third substantially solid biomass fraction from a third substantially liquid fraction comprising neutral lipids, wherein the third substantially solid biomass fraction comprises carbohydrates and separating the neutral lipids into carotenoids and omega-3 rich oil. | 2012-02-02 |
20120029185 | NOVEL INTERMEDIATES IN THE PREPARATION OF 1,4-DIPHENYL AZETIDINONE - The process of the present invention relates to a method for the synthesis of a 1,4-diphenylazetidinone of formula (VIII) by using novel oxime intermediates. | 2012-02-02 |
20120029186 | AZA-DIBENZOCYCLOOCTYNES AND METHODS OF MAKING AND USING SAME - Convenient methods of preparing aza-dibenzocyclooctynes are disclosed herein. Aza-dibenzocyclooctynes attached to a surface are also disclosed herein. Aza-dibenzocyclooctynes can be reacted with azides to form heterocyclic compounds. Such reactions can be useful in a wide variety of applications including, for example, labeling surfaces. | 2012-02-02 |
20120029187 | HALOALKYLSULFONANILIDE DERIVATIVE - Novel herbicides are provided. | 2012-02-02 |
20120029188 | Substituted Aniline Derivatives - The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections. | 2012-02-02 |
20120029189 | PROCESS FOR THE PREPARATION OF HISTAMINE H3 RECEPTOR MODULATORS - The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders. | 2012-02-02 |
20120029190 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF - Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuro-muscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein. | 2012-02-02 |
20120029191 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES - The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor. | 2012-02-02 |
20120029192 | Pyrazole Derivatives - This invention relates to pyrazole derivatives of formula (I) | 2012-02-02 |
20120029193 | POLYMERIZABLE MONOMERS - A monomer of formula (1) is provided wherein R | 2012-02-02 |
20120029194 | LIQUID CRYSTAL COMPOUND HAVING DIFLUOROPROPENYLENEOXY BONDING GROUP - The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large optical anisotropy and a large dielectric anisotropy; a compound represented by formula (1): | 2012-02-02 |
20120029195 | METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR - A method for producing an alcohol compound, wherein a carboxylic acid ester compound is reduced with hydrogen in the presence of a ruthenium complex which is obtained by reacting a pyridine compound having at least one optionally substituted amino group with a ruthenium compound. | 2012-02-02 |
20120029196 | PURIFICATION 4-AZA-ANDROST-1-ENE-17-OIC ACID FROM 4-AZA-ANDROSTAN-17-OIC ACID - The present invention relates to a process of separation of 4-aza-androst-1-ene-17-oic acid from 4-aza-androstan-17-oic acid, which brings to 4-aza-androst-1-ene-17-oic containing less than 0.05% w/w of 4-aza-androstan-17-oic acid, with high yield and productivity. In particular, the present invention relates to a process for the separation of 4-aza-androstan-17-oic acid from 4-aza-androst-1-ene-17-oic acid, comprising the steps of treating the crude 4-aza-androst-1-ene-17-oic acid with formic acid and recovering the purified 4-aza-androst-1-ene-17-oic acid containing 4-aza-androstan-17-oic acid in w/w % less than 0.05%. | 2012-02-02 |
20120029197 | Method for Preparing Sulfur-Containing Compounds - The invention provides a method for preparing sulfur-containing compounds, the method comprising reacting a donor compound comprising at least one sulfur having at least one lone pair of electrons, with an acceptor compound; wherein the reaction occurs in the presence of an amine, optionally an amine catalyst, capable of activating the sulfur having at least one lone pair of electrons; and wherein the reaction occurs via the formation of an transient intermediate species, optionally a transient intermediate species, between the amine, optionally the amine catalyst and the donor compound; and wherein the donor compound is selected from the group consisting of a sulfurous acid, a sulfenic acid and a sulfinic acid or a salt, ester or amide of a sulfurous acid, a sulfenic acid and a sulfinic acid. The invention also provides sulfur-containing compounds of the formula: wherein R is selected from: (a) 1-(4-Nitro-phenyl)-3-oxo-3-phenyl-propane; (b) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-phenyl-ethane; (c) 1-(4-Methoxy-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (d) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-(4-nitro-phenyl)-ethane; (e) 1-(4-Fluoro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (f) 1-(4-Chloro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; and (g) 3-Oxo-cyclohexane. Finally, the invention provides use of chiral sulfur-containing compounds obtainable by the above-mentioned method or chiral sulfur-containing compounds as mentioned above for the resolution of racemic mixtures of amines. | 2012-02-02 |
20120029198 | ESTERS OF O-SUBSTITUTED HYDROXY CARBOXYLIC ACIDS AND PREPARATIONS THEREOF - Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: | 2012-02-02 |
20120029199 | SYNTHESIS OF ENONE INTERMEDIATE - The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate. | 2012-02-02 |
20120029200 | Stem Cell Differentiating Agents and Uses Therefor - The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively. | 2012-02-02 |
20120029201 | PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL - The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid. | 2012-02-02 |
20120029202 | Process for the Preparation of 5-Substituted 3-Aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles - The present invention relates to a process for the manufacturing of 5-substituted 3-aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles of formula (I) | 2012-02-02 |
20120029203 | Synthesis Of Triethylenetetramines - Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity. | 2012-02-02 |
20120029204 | SYNTHESIS OF SUBSTITUTED-3-AMINOPYRAZOLES - The present invention discloses a process of preparing compound of formula (I): wherein A, M, and Z are as defined herein. An example of a compound of formula (I) is 3-amino-1-methyl-1H-1′H-4,4′-bispyrazole. | 2012-02-02 |
20120029205 | Hydrated Sodium Salt Form of Celecoxib - Hydrated celecoxib sodium salt forms and processes to prepare hydrated celecoxib sodium salt forms are disclosed. The celecoxib sodium salt forms are particularly useful and suitable for pharmaceutical applications. | 2012-02-02 |
20120029206 | DYE-SENSITIZED SOLAR CELL, PHOTOELECTRIC CONVERSION ELEMENT, AND DYE FOR USE IN THE SOLAR CELL AND THE ELEMENT - Provided are a squarylium dye having a carboxyindolenine structure and an N-alkyl substituent, and a photoelectric conversion element having high photoelectric conversion efficiency in a near-infrared region and a dye-sensitized solar cell, both of which are produced using the squarylium dye. The photoelectric conversion element or dye-sensitized solar cell uses a compound represented by the formula (1) as the squarylium dye. In the formula (1), R | 2012-02-02 |
20120029207 | Novel Crystalline Form of Atorvastatin Hemi-calcium Salt, Hydrate Thereof, And Method of Producing The Same - The present invention provides a novel crystalline form of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-mthylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug, a hydrate thereof and a preparation method thereof: | 2012-02-02 |
20120029208 | PROCESS FOR (3R, 5R)-7-[2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4- [(4-HYDROXY METHYL PHENYL AMINO) CARBONYL]-PYRROL-1-YL]-3, 5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT - The present invention relates to processes for the manufacture of (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol- | 2012-02-02 |
20120029209 | METHOD FOR SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE - A method for synthesizing [ | 2012-02-02 |
20120029210 | Process for the synthesis of strontium ranelate and its hydrates - Process for the industrial synthesis of strontium ranelate of formula (I): | 2012-02-02 |
20120029211 | Catalytic Wittig and Mitsunobu Reactions - A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine. | 2012-02-02 |
20120029212 | METHOD FOR THE PREPARATION OF (S)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE) - A method for the preparation of a duloxetine hydrochloride salt from a duloxetine base, comprising the steps of: reacting duloxetine base with concentrated hydrochloric acid in ethylmethylketone; and crystallizing duloxetine hydrochloride salt from said concentrated hydrochloric acid in ethylmethylketone. | 2012-02-02 |
20120029213 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided. | 2012-02-02 |
20120029214 | CATALYST FOR THE OXIDATION OF O-XYLENE AND/OR NAPHTHALENE TO PHTHALIC ANHYDRIDE - The present invention relates to a catalyst for the oxidation of o-xylene and/or naphthalene to phthalic anhydride, which has a plurality of catalyst zones which are arranged in series in the reaction tube and have been produced using an antimony trioxide which comprises a significant proportion of valentinite. The present invention further relates to a process for gas-phase oxidation, in which a gas stream comprising at least one hydrocarbon and molecular oxygen is passed through a catalyst produced using an antimony trioxide which comprises a significant proportion of valentinite. | 2012-02-02 |
20120029215 | METHOD FOR MANUFACTURING TRIMELLITIC ANHYDRIDE ARYL ESTER - Disclosed is a method for manufacturing a trimellitic anhydride aryl ester in an efficient, high-yielding manner, wherein carboxylic acid lithium salt is used as a catalyst when a carboxylic acid aryl ester and trimellitic anhydride are caused to undergo an ester exchange reaction to manufacture a trimellitic anhydride aryl ester. | 2012-02-02 |
20120029216 | SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL - A manufacturing process for making terameprocol (1) which includes the following reaction scheme, wherein a first general reaction is the formation of a furan intermediate (39) and a second general reaction is the ring-reduction and ring-opening of the furan intermediate (39) to form the terameprocol (1): | 2012-02-02 |
20120029217 | PROCESS FOR PRODUCING EPOXY COMPOUND - According to the present, invention, a process for producing an epoxy compound, where an epoxy compound can be selectively produced from olefins with good yield at low cost in a safe manner by a simple operation under mild conditions without using a quaternary ammonium salt or a metal compound, is provided. The present invention relates to a process for producing an epoxy compound, comprising epoxidizing a carbon-carbon double bond of an organic compound having a carbon-carbon double bond by using hydrogen peroxide as an oxidant, wherein the epoxidation is carried by out using an organic nitrile compound and an organic amine compound. | 2012-02-02 |
20120029218 | SUPPORTED CATALYST SYSTEMS AND METHOD OF MAKING BIODIESEL PRODUCTS USING SUCH CATALYSTS - A heterogeneous catalyst system, a method of preparing the catalyst system and a method of forming a biodiesel product via transesterification reactions using the catalyst system is disclosed. The catalyst system according to one aspect of the present disclosure represents a class of supported mixed metal oxides that include at least calcium oxide and another metal oxide deposited on a lanthanum oxide or cerium oxide support. Preferably, the catalysts include CaO—CeO | 2012-02-02 |
20120029219 | LOW ZIRCONIUM, HAFNIUM-CONTAINING COMPOSITIONS, PROCESSES FOR THE PREPARATION THEREOF AND METHODS OF USE THEREOF - This invention relates to hafnium-containing compositions having a zirconium concentration of less than about 500 parts per million, a process for producing the hafnium-containing compositions, organometallic precursor compositions containing a hafnium-containing compound and having a zirconium concentration of less than about 500 parts per million, a process for producing the organometallic precursor compositions, and a method for producing a film or coating from the organometallic precursor compositions. The organometallic precursor compositions are useful in semiconductor applications as chemical vapor deposition (CVD) or atomic layer deposition (ALD) precursors for film depositions. | 2012-02-02 |
20120029220 | TITANIUM COMPLEX, PROCESSES FOR PRODUCING THE SAME, TITANIUM-CONTAINING THIN FILM, AND PROCESS FOR PRODUCING THE SAME - A subject for the invention is to provide novel titanium complexes which have a high vapor pressure and high thermal stability and serve as an excellent material for producing a titanium-containing thin film by a technique such as the CVD method or ALD method and to further provide processes for producing these complexes, titanium-containing thin films produced from the complexes, and a process for producing the thin films. The invention relates to producing a titanium complex represented by general formula (1): | 2012-02-02 |
20120029221 | SILANE COMPOSITIONS FOR POLYESTER NANOCOMPOSITES - Novel silane compositions have been prepared by reacting a 3-isocyanatopropyl trialkoxysilane with an alcohol or diol having a divalent alkylene or alkylene-ether group. The alcohol or diol has a formula weight less than about 5000. The compositions can be used to modify the surfaces of inorganic oxygen-containing materials, including but not limited to silica, silicates, borosilicates, aluminosilicates, days, and metal oxides. | 2012-02-02 |
20120029222 | SURFACE-MODIFIED PARTICLES FOR POLYESTER NANOCOMPOSITES - Silica nanoparticles that have been subjected to surface treatment with novel silane compositions exhibit improved dispersion in polyester nanocomposites. The novel silane compositions are prepared by reacting a 3-isocyanatopropyl trialkoxysilane with an alcohol or diol having a divalent alkylene or alkylene-ether group, where the alcohol or diol has a formula weight less than about 5000. The surface treatment of the nanoparticles leads to improvements in mechanical properties and haze reduction in polyester nanocomposites containing them. | 2012-02-02 |
20120029223 | METHOD FOR PRODUCTION OF SUBSTITUTED ALKYL MALONIC ESTERS AND DERIVATIVES THEREOF - Substituted alkyl methyl malonate compounds are produced in an essentially one step method, the method suitable for large scale production of alkyl malonate compounds. According to one embodiment the method comprises reacting a methyl malonate with a di-functional, doubly tosylated, alkyl chain. | 2012-02-02 |
20120029224 | PROCESS FOR THE PREPARATION OF HALOGENATED ARYL PHOSPHONATES - A process for preparing halogen-substituted aryl phosphonates represented by formula (I): wherein each Hal independently represents halogen; k is 1 or 2; n is an integer between 1 and 5, inclusive; m is an integer between 1 and 3, inclusive; and R is a straight or branched C1-C5 alkyl group which may be optionally substituted with one or more halogen atoms, which process comprises reacting under heating a compound represented by the following formula: wherein X is a leaving group, with trialkyl phosphite of the formula (RO) | 2012-02-02 |
20120029225 | DMAPN Having a Low DGN Content and a Process for Preparing DMAPA from DMAPN Having a Low DGN Content - The present invention relates to a process for preparing 3-dimethylaminopropylamine (DMAPA) by reacting 3-dimethylaminopropionitrile (DMAPN) with hydrogen in the presence of a catalyst, wherein the DMAPN used has a content of 2-(dimethylaminomethyl)glutaronitrile (DGN) of 300 ppm by weight or less, based on the DMAPN used. | 2012-02-02 |
20120029226 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES - The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding. | 2012-02-02 |
20120029227 | METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER - A method for producing a cyclopropanecarboxylate represented by formula (III): | 2012-02-02 |
20120029228 | CHEMICAL RECYCLING OF PLA BY ALCOHOLYSIS - A process for recycling a polymer blend necessarily containing PLA, comprising grinding, compacting, dissolving in a solvent of PLA, removing the undissolved contamining polymers, alcoholysis depolymerisation reaction and purification steps. | 2012-02-02 |
20120029229 | METHOD FOR PRODUCING HIGH PURITY TERMINAL OLEFIN COMPOUND - An industrially advantageous method for producing a high purity terminal olefin is disclosed, comprising the steps of (a) contacting a mixture comprising a terminal olefin represented by formula (1): | 2012-02-02 |
20120029230 | METHOD FOR PREPARING CHIRAL BACLOFEN - The present invention provides a novel method for preparing chiral Baclofen with higher yield, higher e.e. value, and lower cost via chiral Michael addition. | 2012-02-02 |
20120029231 | METHODS FOR REMOVING VICINAL DIOLS FROM LACTIC ACID FERMENTATION BROTH - Embodiments of a method for removing vicinal diols from a lactic acid fermentation broth comprise the steps of contacting the lactic acid fermentation broth with functionalized silica comprising at least one hydrophobic ligand to facilitate binding of the vicinal diols to the hydrophobic ligand, and separating the contacted lactic acid fermentation broth from the functionalized silica to remove the vicinal diols. | 2012-02-02 |
20120029232 | METHOD FOR ADSORBING FLUOROCARBOXYLIC ACID HAVING ETHER BOND AND METHOD FOR COLLECTING SAME - Disclosed are an adsorption process whereby a fluorocarboxylic acid having an ether bond can be adsorbed to a high extent by using active carbon without changing the form thereof, and a desorption process whereby the adsorbed material can be desorbed from the active carbon to thereby enable the reuse of the active carbon and the adsorbed material. In the aforesaid processes, a solution containing a fluorocarboxylic acid having an ether bond is contacted with active carbon and thus the active carbon is allowed to adsorb the fluorocarboxylic acid, to thereby give a solution having a small fluorocarboxylic acid content. Then, the active carbon having adsorbed the fluorocarboxylic acid is heated to thereby desorbs the fluorocarboxylic acid from the active carbon. | 2012-02-02 |
20120029233 | METHOD AND APPARATUS FOR RECOVERY OF AMINE FROM AMINE-CONTAINING WASTE WATER AND REGENERATION OF CATION EXCHANGE RESIN - Provided is an apparatus for recovering amines from amine-containing waste water generated in power stations, etc., and regenerating a cation exchange resin. The apparatus includes: a cation exchange resin layer capturing amines from amine-containing waste water and eluting the amines therefrom; a degassing tower degassing the eluted amines; a vacuum pump connected to the degassing tower; and a condensation and cooling tower condensing the degassed amines at a temperature of −33° C. or lower, wherein the amines captured in the cation exchange resin layer are eluted by injecting a strong acidic solution, while the resin is regenerated, and the amines eluted by the strong acidic solution is subjected to vacuum degassing and then recovered. Provided also is a method for recovering amines and regenerating a cation exchange resin using the apparatus. The apparatus and method for recovering amines and regenerating a cation exchange resin improve the quality of effluent water from power stations, etc., and increase the cost-efficiency through the recycle of amines. | 2012-02-02 |
20120029234 | BORON CONTAINING FUNCTIONALIZING AGENT - The present invention relates to functionalizing agents that are particularly useful for functionalizing living rubbery polymers to make the polymer more compatible with fillers, such as carbon black and silica. These functionalizing agents are comprised of a boron containing compound having a structural formula selected from the group consisting of: | 2012-02-02 |
20120029235 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN - The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation. | 2012-02-02 |
20120029236 | CAPPED STRUCTURE ORGANIC FILM COMPOSITIONS - A capped structured organic film comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film. | 2012-02-02 |
20120029237 | Autocatalytic Process for the Synthesis of Chiral Propargylic Alcohols - An autocatalytic process for the synthesis of chiral propargylic alcohols. | 2012-02-02 |
20120029238 | PROCESS FOR THE PREPARATION OF CRYSTALLINE MIXTURES OF ALPHA-HYDROXYCARBONYL DERIVATIVES OF ALPHA-METHYLSTYRENE DIMERS - Process for the preparation of the powdery crystalline mixtures of alpha-hydroxycarbonyl derivatives of alpha-methylstyrene dinners comprising the use of a solvent having polarity from 0 to 0.1. | 2012-02-02 |
20120029239 | RECOVERY OF ACETOPHENONE DURING THE PRODUCTION OF PHENOL - A method for producing acetophenone comprising: treating one or more alkylbenzenes comprising s-butylbenzene to produce a feed comprising phenol and acetophenone; separating a crude phenol stream from the feed under crude phenol separation conditions effective to produce a crude phenol heavies; and, separating an acetophenone stream directly from the crude phenol heavies under azeotropic distillation conditions. | 2012-02-02 |
20120029240 | ALLYL AND PROPARGYL ETHERS - Allyl and propargyl ethers of the formula X—C(R | 2012-02-02 |