05th week of 2013 patent applcation highlights part 51 |
Patent application number | Title | Published |
20130030023 | ORALLY BIOAVAILABLE DABIGATRAN PRODRUGS FOR THE TREATMENT OF DISEASES - The present invention relates to prodrug derivatives of dabigatran, their use in the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis. | 2013-01-31 |
20130030024 | Method of Administering Pirfenidone Therapy - The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes. | 2013-01-31 |
20130030025 | USE OF POTASSIUM CHANNEL BLOCKERS TO TREAT CEREBRAL PALSY - Disclosed herein is the use of aminopyridines, such as 3-aminopyridine, 4-aminopyridine or 3,4-diaminopyridine, in the management and treatment of cerebral palsy patients of all ages. | 2013-01-31 |
20130030026 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 2013-01-31 |
20130030027 | HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE - The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C | 2013-01-31 |
20130030028 | DESFERRITHIOCIN POLYETHER ANALOGUES - Compounds represented by structural formulas described herein, such as Structural Formula (I): | 2013-01-31 |
20130030029 | Glucagon Antagonists - Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof. Formula I | 2013-01-31 |
20130030030 | ALLANTOIN-CONTAINING SKIN CREAM - An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The composition is in the form of an oil-in-water emulsion. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant. | 2013-01-31 |
20130030031 | Novel Compounds - Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy. | 2013-01-31 |
20130030032 | KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN - The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution which provides increased visual acuity in users and wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient which is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac. | 2013-01-31 |
20130030033 | 4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS - This invention relates to novel 4-trimethylammoniobutyrates of the formula | 2013-01-31 |
20130030034 | MODULATION OF TIMP1 AND TIMP2 EXPRESSION - Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis. | 2013-01-31 |
20130030035 | IDENTIFICATION OF MICRO-RNAS INVOLVED IN NEUROMUSCULAR SYNAPSE MAINTENANCE AND REGENERATION - The present invention relates to the identification of miRNAs that are involved in the process of neuromuscular synaptic maintenance and regeneration following injury or disease. Modulation of these miRNAs is proposed as treatment for spinal cord injury and neurodegenerative disease. | 2013-01-31 |
20130030036 | MODULATION OF FORKHEAD BOX O1A EXPRESSION - Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes. | 2013-01-31 |
20130030037 | RNAi Modulation Of RSV And Therapeutic Uses Thereof - The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses. | 2013-01-31 |
20130030038 | Dermatological, Pharmaceutical Composition Suitable for Oligonucleotides - The invention relates to a cosmetic and/or dermatological and/or pharmaceutical composition for the topical use and application of oligonucleotides, in particular antisense-oligonucleotides such as DNAzyme, siRNAs, asDNAs or ribozymes for use as an agent against inflammatory diseases by means of emulsions having a dispersed, internal, discontinuous aqueous phase. | 2013-01-31 |
20130030039 | NOVEL MULTIDRUG RESISTANCE-ASSOCIATED POLYPEPTIDE - Compositions and methods are disclosed for improving the effectiveness of a chemotherapeutic regimen to eradicate multidrug-resistant transformed cells from the body of a mammal, preferably from the body of a human. The present disclosure capitalizes on the discovery of a novel multidrug-resistance associated protein (MRP), herein designated MRP-β. The disclosed compositions include MRP-β nucleic acids, including probes and antisense oligonucleotides, MRP-β polypeptides and antibodies, MRP-β expressing host cells, and non-human mammals transgenic or nullizygous for MRP-β. The disclosed methods include methods for attenuating aberrant MRP-β gene expression, protein production and/or protein function. In addition, methods are disclosed for identifying and using a modulator, such as an inhibitor, of MRP-β. Preferably, the modulator is a small molecule. | 2013-01-31 |
20130030040 | METHODS AND COMPOSITIONS FOR INCREASING SIALIC ACID PRODUCTION AND TREATING SIALIC RELATED DISEASE CONDITIONS - Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3. | 2013-01-31 |
20130030041 | NEAR-INFRARED LIGHT-ACTIVATED PROTEINS - Methods and constructs are provided for controlling processes in live animals, plants or microbes via genetically engineered near-infrared light-activated or light-inactivated proteins including chimeras including the photosensory modules of bacteriohytochromes and output modules that possess enzymatic activity and/or ability to bind to DMA, RNA, protein, or small molecules. DNA encoding these proteins are introduced as genes into live animals, plants or microbes, where their activities can be turned on by near-infrared light, controlled by the intensity of light, and turned off by near-infrared light of a different wavelength than the activating light. These proteins can regulate diverse cellular processes with high spatial and temporal precision, in a nontoxic manner, often using external light sources. For example, near-Infrared light-activated proteins possessing nucleotidyl cyclase, protein kinase, protease, DNA-binding and RNA-binding activities are useful to control signal transduction, cell apopiosis, proliferation, adhesion, differentiation and other cell processes. | 2013-01-31 |
20130030042 | NUCLEIC ACIDS FOR TARGETING MULTIPLE REGIONS OF THE HCV GENOME - Compositions and methods effective for modulating Hepatitis C viral infection are provided. | 2013-01-31 |
20130030043 | TREATING GLAUCOMA, CARDIOVASCULAR DISEASES, AND RENAL DISEASES - This document provides methods and materials related to treating glaucoma, ocular hypertension, cardiovascular diseases, and renal diseases. For example, this document provides isolated nucleic acid molecules and viral vectors (e.g., lentiviral vectors) containing isolated nucleic acid molecules. Methods for reducing intraocular pressure as well as symptoms and progression of cardiovascular and renal diseases also are provided. | 2013-01-31 |
20130030044 | NEW SERIES OF ARTEMISININ DERIVATIVES AND PROCESS FOR PREPARATION THEREOF - This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2[10′β-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalized artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines | 2013-01-31 |
20130030045 | METHOD OF PREVENTING AND TREATING OSTEOPOROSIS - The invention discloses a method of preventing and treating osteoporosis. The method comprises a step of enhancing osteoblast differentiation and inhibiting osteoclast differentiation by administering a pharmaceutically effective amount of a composition comprising 6-hydroxy flavone compound or 7-methoxy flavone compound, or at least one pharmaceutically acceptable salt thereof to a subject. | 2013-01-31 |
20130030046 | USE OF BLACK SOYBEAN HULL EXTRACTS IN MANUFACTURE OF PRODUCTS FOR PREVENTING AND TREATING OSTEOARTHRITIS - The application relates to a use of black soybean hull extracts in the manufacture of foods, health care products and medicaments. The black soybean hull extracts can be added to foods or drinks, and also can be made into all kinds of oral health care products and oral medicaments used by conventional methods of preparing traditional Chinese medicine preparations. The products can significantly improve symptoms of osteoarthritis, and also can stabilize or even reverse the degradation of cartilage of osteoarthritis. | 2013-01-31 |
20130030047 | Fatty Acid Derivatives of Catechins and Methods of Their use - The present disclosure relates to fatty acid derivatives of green tea catechins including epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), epigallocatechin gallate (EGCG) and their epimers (e.g., catechin, catechin gallate, gallocatechin, gallocatechin gallate) or their mixtures and/or green tea extracts. | 2013-01-31 |
20130030048 | COMPOSITION FOR INDUCING MULTIPLE NUCLEAR DIVISION OF CELLS - The present invention relates to the novel use of a composition comprising a compound of the formula I: | 2013-01-31 |
20130030049 | METHODS OF TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS - This disclosure is directed to the use of TOFA in the treatment of inflammatory disorders, including dermatological disorders. | 2013-01-31 |
20130030050 | TREATMENT OF OSTEOPOROSIS - According to the invention there is provided a compound of formula (I): wherein R | 2013-01-31 |
20130030051 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF - The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection. | 2013-01-31 |
20130030052 | COMPOSITIONS AND METHODS FOR THE SUSTAINED RELEASE OF BETA-ALANINE - Methods and compositions are provided for increasing the anaerobic working capacity of muscle and other tissues. Also provided are compositions formulated for the sustained release of free beta-alanine. Also provided is a dietary supplement formulated, for example, as a solid food product, an edible suspension, liquid or semi-liquid as described herein. | 2013-01-31 |
20130030053 | NOVEL NIDDM REGIMEN - The present invention relates to the use of a short-acting oral hypoglycemic agent and to a novel regimen in the treatment of type 2 diabetes in which the endogenous secretion of insulin is stimulated in connection with meals by administering in connection with the meals a short-acting oral hypoglycaemic agent. Also, the present invention relates to a method of achieving significantly improvement in the glycaemic control by a combined use of repaglinide and metformin in NIDDM patients poorly controlled on metformin alone. | 2013-01-31 |
20130030054 | HIGHLY FLAVORED ORNITHINE-CONTAINING ALCOHOL-FREE MALT BEVERAGE - An object of the present invention is to provide an ornithine-containing alcohol-free malt beverage which is provided with health functions of ornithine imparted to an alcoholic beverage-flavored alcohol-free malt beverage containing substantially no alcohol component and which retains an excellent flavor of the alcohol-free malt beverage, and to provide a method for producing the same. The ornithine-containing alcohol-free malt beverage of the present invention is produced using ornithine hydrochloride and ornithine aspartate in combination as ornithine raw materials. For this production, 20% or more by weight of ornithine hydrochloride in terms of ornithine is used with respect to the total weight of ornithine hydrochloride and ornithine aspartate in terms of ornithine. The ornithine-containing alcohol-free malt beverage thus produced is provided with health functions of ornithine and retains an excellent flavor of an alcohol-free malt beverage. In this way, the object can be attained. In the present invention, an organic acid, in addition to ornithine hydrochloride and ornithine aspartate, may be added to adjust the pH value of the product. Examples of the added organic acid include one or more organic acids selected from malic acid, gluconic acid and phytic acid. | 2013-01-31 |
20130030055 | COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS, HAIR THINNING, AND HAIR COLOR LOSS - Described herein are compositions including at least one prostaglandin or prostamide and methods for using these compositions for increasing hair growth on the scalp eyebrow growth. | 2013-01-31 |
20130030056 | METHODS OF DELIVERING PHARMACEUTICAL AGENTS - Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject. | 2013-01-31 |
20130030057 | METHODS AND COMPOSITIONS COMPRISING AT LEAST ONE ALPHA3 BETA4 nAChR ANTAGONIST OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF - The present invention is directed to methods and formulations for treating, modifying, and/or managing gastrointestinal secretion, and intestinal conditions that cause the same. Methods of using at least one α3 β4 nAChR antagonist and formulations comprising at least one α3 β4 nAChR antagonist, or pharmaceutically acceptable salt thereof, are included. | 2013-01-31 |
20130030058 | KIT AND METHOD FOR PRODUCING BONE CEMENT - A kit for producing bone cement includes at least one paste A and one paste B. Paste A contains at least one monomer (a1) for radical polymerization; at least one polymer (a2) insoluble in monomer (a1); at least one polymer (a3) soluble in monomer (a1); and at least one radical polymerization initiator (a4). The weight ratio of the at least one polymer (a2) to the at least one polymer (a3) is at least 2 to 1. Paste B contains at least one monomer (b1) for radical polymerization; at least one polymer (b2) and at least one accelerator (b3) soluble in monomer (b1); and optionally a polymer (b4) insoluble in monomer (b | 2013-01-31 |
20130030059 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS, CELL LINES THAT EXPRESS SAID RECEPTORS, AND TASTE COMPOUNDS - The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T11 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. | 2013-01-31 |
20130030060 | Glucosyl Stevia Composition - Glucosyl stevia compositions are prepared from steviol glycosides of | 2013-01-31 |
20130030061 | FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM - The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. | 2013-01-31 |
20130030062 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 2013-01-31 |
20130030063 | PROCESS AND METHOD FOR THE PRODUCTON OF DIMETHYLETHER (DME) - Disclosed herein is a process for the production of fuel grade DME from carbonaceous fuels, including a pressurized multi-stage progressively expanding fluidized bed gasifier and an oxyblown autothermal reformer to produce a synthesis gas (syngas) with desirable hydrogen to carbon monoxide molar ratio, which then undergoes gas-phase DME one-step direct synthesis in a fluid pluralized bed reactor over an attrition resistant bifunctional catalyst. The crude DME thus obtained is purified in a two column distillation unit to produce a fuel grade DME having a purity greater than 99.98 mole %. | 2013-01-31 |
20130030064 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 2013-01-31 |
20130030065 | HEAT-EXPANDABLE MICROSPHERES AND A PROCESS FOR PRODUCING THE SAME - A method that produces heat-expandable microspheres includes the use of a shell of thermoplastic resin and a non-fluorine blowing agent encapsulated therein having a boiling point not higher than the softening point of the thermoplastic resin. The method includes a step of dispersing an oily mixture containing a polymerizable component, the blowing agent, and a polymerization initiator containing a peroxydicarbonate in an aqueous dispersing medium to polymerize the polymerizable component contained in the oily mixture. The resultant heat-expandable microspheres have a shell which is less apt to become thinner than its theoretical value, contain minimum amount of resin particle inside their shell, and have excellent heat-expanding performance. | 2013-01-31 |
20130030066 | POLYMERIC FLAME RETARDANT - The invention relates to a polymer composition containing
| 2013-01-31 |
20130030067 | Sugar-Based Polyurethanes, Methods for Their Preparation, and Methods of Use Thereof - Polyurethane foams which are highly flame resistant are described, as well as the production of such polyurethane foams by the reaction between a natural polyol, such as sucrose or a blend of mono- or disaccharides in place of the standard hydrocarbon-based polyol component, a polyisocyanate and water in the presence of a suitable polyurethane forming catalyst and a flame retardant, and optionally one or more components such as surfactants and/or emulsifiers. The resultant polyurethane foam has a bio-based solid content ranging from about 17% to 30%, may be formulated in a variety of foam densities for a variety of applications, and exhibits a high degree of fire and burn resistance, as exhibited by the flame spread index and the smoke spread values. | 2013-01-31 |
20130030068 | FLEXIBLE POLYURETHANE FOAM AND PROCESS FOR ITS PRODUCTION - To provide a process for producing a flexible polyurethane foam that has excellent moldability with a long cream time, and that has excellent hardness and durability. | 2013-01-31 |
20130030069 | DEFORMABLE, RIGID POLYSTYRENE FOAM BOARD - Provided are methods for producing a high strength, but easily deformed, polystyrene foam board that can endure repeated deformations from its original configuration into more complex curved shapes without damaging the board integrity or substantially reducing its structural strength. Also provided are rigid polystyrene foam boards produced by this method that exhibit improved bending and impact resistance while substantially retaining or improving other properties, for example, the thermal dimensional stability and fire resistance, exhibited by corresponding conventional XPS foam boards. The foamable compositions may incorporate one or more of a variety of polymer processing aids for the purpose of altering the performance of the final foam products, thereby allowing the properties of the final foam product to be customized to some degree. | 2013-01-31 |
20130030070 | PREPARATION OF CROSSLINKED ORGANIC POROUS PARTICLESRELATED APPLICATIONS - Crosslinked organic polymeric porous particles have a crosslinked organic solid phase and discrete pores dispersed within the crosslinked solid phase which pores are isolated from each other. These porous particles are prepared using one or more water-in-oil emulsions containing a polyfunctional reactive compound, a reagent that causes crosslinking, optionally an ethylenically unsaturated polymerizable monomer, and optionally an organic solvent, and can include various marker materials. | 2013-01-31 |
20130030071 | END-FUNCTIONALIZED POLYMERS - This invention relates to end-functionalized living polymers or copolymers having a structure represented by the general formula 1 or 2, wherein R | 2013-01-31 |
20130030072 | Synthesis of a Highly Crystalline, Covalently Linked Porous Network - Porous networks are described linked by boronates. Also described are processes for producing the porous networks. The porous networks are formed by reacting a polyboronic acid with itself or with a polydiol, a polydiamine, or a polyamino alcohol. The resulting boronate linkage is covalently bonded. The characteristics and properties of the resulting porous material can be varied and altered by changing the reactants and by incorporating functional groups into the reactants. Of particular advantage, the porous materials can be formed at or near atmospheric pressure and at low temperature in the presence of one or more solvents. | 2013-01-31 |
20130030073 | AMINE-INITIATED POLYOLS FROM RENEWABLE RESOURCES AND PROCESSES FOR THEIR PRODUCTION AND USE - Amine-initiated polyether polyols are made by reacting an amine adduct with a triglyceride in the presence of an alkylene oxide to obtain a polyol having a total renewables content of at least 20%. The polyols produced in this manner are particularly useful for the production of polyurethane and a polyisocyanurate foams | 2013-01-31 |
20130030074 | PROCESS FOR THE CONTINUOUS PRODUCTION OF POLYETHEROLS - The present invention relates to a process for the continuous production of polyether alcohols. | 2013-01-31 |
20130030075 | POLYMERS MADE OF RENEWABLE RESOURCES - Polycondensates with long-chain linear methylene sequences, their production, a method for producing linear odd-numbered C | 2013-01-31 |
20130030076 | RADIATION CURABLE COMPOSITION, PROCESS OF PRODUCTION AND USE THEREOF - The invention relates to a radiation curable composition for taking a dental impression comprising (A) a cationically hardenable compound comprising at least one aziridine moiety, and (B) a radiation sensitive starter, the radiation sensitive starter comprising an onium salt, a ferrocenium salt, a combination or mixture thereof. | 2013-01-31 |
20130030077 | POLYMER AND PHOTOSENSITIVE RESIN COMPOSITION COMPRISING THE SAME - The present invention relates to a polymer having a novel structure and a photosensitive resin composition comprising the same. A photosensitive resin composition comprising a polymer according to the present invention has a high taper angle and excellent adhesion strength. Accordingly, the photosensitive resin composition comprising the polymer according to the present invention may be applied to various photosensitive materials, and particularly, may be preferably applied when a color filter pattern for LCD is manufactured. | 2013-01-31 |
20130030078 | RADICAL-POLYMERIZABLE RESIN, RADICAL-POLYMERIZABLE RESIN COMPOSITION, AND CURED MATERIAL THEREOF - Provided is a radical-polymerizable resin capable of giving a cured material which is satisfactorily flexible, can relax stress upon usage as an adhesive, and does not cause disadvantages such as separation at the adhesive interface or breakage of an adherend, which stress occurs between the adhesive and the adherend upon heating or cooling and is caused by difference in coefficient of thermal expansion between them. | 2013-01-31 |
20130030079 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK - High refractive index copolymers with reduced tack are disclosed. The copolymers, which are particularly suitable for use as ophthalmic device materials, comprise a benzhydryl methacrylate or benzydryl methacrylate derivative monomer. | 2013-01-31 |
20130030080 | DENTAL COMPOSITION - There is provided a dental composition comprising at least one kind of filler and resin matrix, wherein the at least one kind of filler comprises a population of particles, wherein the population of particles has an average particle size from 110 to 500 μm, the maximum particle size of the population of particles is less than 1.4 times the average particle size, and the D30 of particle size distribution of the population of particles is no less than 0.9 times the average particle size. | 2013-01-31 |
20130030081 | CURABLE COMPOSITION AND CURED PRODUCT FOR DENTAL USE - The present invention provides a curable composition allowing a cured product having high aesthetic quality, strength and durability along with having high surface lubricating property. A curable composition in the present invention comprises: an inorganic powder and a polymerizable monomer, wherein the inorganic powder contains a spherical composite powder, the spherical composite powder has a complex of silicon dioxide and at least one of alumina and zirconia, and an amorphous part and a crystalline part are mixed in the spherical composite powder. A refractive index difference is not more than 0.05 between the spherical composite powder and a cured product obtained by curing only a compound excluded the spherical composite powder. | 2013-01-31 |
20130030082 | CURABLE COMPOSITION AND CURED PRODUCT FOR DENTAL USE - The present invention provides a curable composition allowing a cured product having high aesthetic quality, strength and durability along with having high surface lubricating property to be formed. The curable composition according to the present invention comprises: an inorganic powder and a polymerizable monomer. The inorganic powder contains a spherical crystallization control powder. The spherical crystallization control powder has a silicon dioxide content in the range of 97 to 100 mass %. An amorphous portion and a crystalline portion are mixed within the spherical crystallization control powder. A refractive index difference is not more than 0.05 between the spherical crystallization control powder and a cured product obtained by curing only constituents other than the spherical crystallization control powder. | 2013-01-31 |
20130030083 | RUBBER COMPOSITION FOR TREAD, METHOD FOR PRODUCING THE SAME, AND HEAVY-LOAD TIRE - The present invention provides a rubber composition for a tread which enables improvement in fuel economy, breaking performance, and abrasion resistance in a balanced manner; a method for producing the rubber composition; and a heavy-load tire. The present invention relates to a rubber composition for a tread of a heavy-load tire, including a modified natural rubber having a phosphorus content of 200 ppm or less, and carbon black. | 2013-01-31 |
20130030084 | RESIN COMPOSITION AND RESIN-MOLDED PRODUCT - Provided is a resin composition including cellulose acetate propionate; from about phr to about 30 phr of at least one of plasticizer selected from an adipate-based plasticizer and a polyester-based plasticizer; and from about 5 phr to about 50 phr of a condensed phosphoric acid ester compound. | 2013-01-31 |
20130030085 | ONE-PACK TYPE RESIN COMPOSITION FOR USE IN BACKING - Provided is the one-pack type backing resin composition which exhibits excellent fall-off resistance, excellent storage stability, and high flame retardancy. A one-pack type backing resin composition includes 100 parts by mass of (A) a (meth)acrylic polymer, and 50 to 500 parts by mass of (B) a flame retardant, the (meth)acrylic polymer (A) being produced by emulsion polymerization of a monomer component, and having a solvent-insoluble content of 0 to 85 mass %, the monomer component including 0.5 to 25 mass % of (a) glycidyl methacrylate, 0.2 to 10 mass % of (b) an unsaturated carboxylic acid monomer, and 70 to 99.3 mass % of (c) an additional copolymerizable monomer (provided that (a)+(b)+(c)=100 mass %). | 2013-01-31 |
20130030086 | REDISPERSIBLE POLYMER POWDER FROM POLYOLEFIN DISPERSIONS AND THE USE THEREOF IN CONSTRUCTION APPLICATIONS - The present invention provides compositions comprising redispersible polymer powders of polyolefins with carboxyl group containing dispersant polymers and vinyl ester copolymers which may further comprise hydraulic or water curable inorganic cements for various construction applications, such as cement tile adhesives. Methods of making redispersible polymer powders of polyolefins are also provided, including forming an aqueous polyolefin dispersion, such as, for example, by mechanical dispersion, followed by drying to form the redispersible polymer powders. | 2013-01-31 |
20130030087 | ADDITIVE FOR HYDRAULICALLY SETTING SYSTEMS WITH IMPROVED PROCESSING - A comb polymer and use thereof for improving the processing of hydraulically setting compositions. The comb polymer has ester, amide and/or ether groups on side chains bound to a main chain and the main chain has at least one acrylic acid unit A or a salt thereof and at least one methacrylic acid unit M or a salt thereof. Processes for producing a hydraulically setting composition with longer processing time. | 2013-01-31 |
20130030088 | Method for Producing Rubberized Concrete Using Waste Rubber Tires - Catalytic partial oxidation using a metal oxide catalyst surface treats crumb rubber that is recovered from waste rubber tires. Advantages of using catalytically oxidized crumb rubber relative to using non-catalytically oxidized crumb rubber in making the rubberized concrete, includes superior mechanical strength and water-repealing capability, lower oxidation temperature and shorter oxidation time, and accelerated hydration times. Rubber oil (a gas condensate) co-produced from the crumb rubber partial oxidation process is equal to or better than the commercial superplasticizers. Industrial scale partial oxidation employs a continuous flow tubular reactor where a crumb rubber/catalyst mixture is fed into the reactor co-currently with an air/nitrogen mixture. | 2013-01-31 |
20130030089 | THERMOPLASTIC RESIN COMPOSITION AND RESIN MOLDED PRODUCT - Process for preparing a thermoplastic resin composition containing an aromatic polycarbonate resin which may include a thermoplastic resin other than the aromatic polycarbonate resin, a granular talc, and optionally a rubber polymer, a flame retardant or a fluorinated polyolefin. The granular talc has a particle size in which a proportion of a 500 μm-mesh screen residue thereof is not less than 55% by weight. | 2013-01-31 |
20130030090 | POLYAMIDE RESIN COMPOSITION AND METHOD FOR PRODUCING POLYAMIDE RESIN COMPOSITION - Disclosed is a polyamide resin composition including 0.01 to 50 parts by mass of cellulose fiber having an average fiber diameter of 10 μm or less in relation to 100 parts by mass of a polyamide resin. Also disclosed is a method for producing the polyamide resin composition, wherein the monomer constituting the polyamide resin and an aqueous dispersion of the cellulose fiber having an average fiber diameter of 10 μm or less are mixed and the resulting mixture is subjected to a polymerization reaction. | 2013-01-31 |
20130030091 | READILY DISSOLVABLE SOLID NONIONIC SYNTHETIC ASSOCIATIVE THICKENERS - The presently disclosed and claimed inventive concept(s) relates to a particulate product. The particulate product comprises a nonionic synthetic associative thickener NSAT) rheology modifier and a dissolution promotion water soluble additive. The NSAT rheology modifier is selected from the group consisting of hydrophobically-modified ethoxylated urethane (HEUR), hydrophobically-modified polyethylene glycol and hydrophobically-modified polyacetal-polyether (HMPAPE). The particulate product is incorporated into a waterborne paint formula. | 2013-01-31 |
20130030092 | Catalyst Composition Comprising Shuttling Agent for Ethylene Multi-Block Copolymer Formation - A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining:
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20130030093 | Flame Retardant Thermoplastic Elastomer Composition with Resistance to Scratch-Whitening - Halogen-free, flame-retardant thermoplastic polyester elastomer (TPE-E) compositions that include at least one thermoplastic polyester elastomer, at least one low-melting, phosphorus-based flame retardant having a melting temperature no higher than 150° C., and a blend of solid intumescent flame retardants comprising a phosphorus-based, organic salt flame retardant and a nitrogen-based organic flame retardant are provided. The presence of the low-melting, phosphorus-based flame retardant renders the compositions more resistant to scratch-whitening. | 2013-01-31 |
20130030094 | POLYCARBONATE RESIN, COMPOSITION OF SAID RESIN, AND MOLDED ARTICLE OF SAID RESIN - To provide a polycarbonate resin composition having improved flame retardancy and moldability. | 2013-01-31 |
20130030095 | FLAME RETARDANT RESIN COMPOSITION AND MOLDED ARTICLE THEREOF - It is an object of the present invention to provide a flame retardant resin composition which is obtained from a plant-derived raw material and has high flame retardancy and excellent physical properties and a molded article thereof. | 2013-01-31 |
20130030096 | FLAME RETARDANT POLY(ARYLENE ETHER)-POLYSILOXANE BLOCK COPOLYMER COMPOSITION AND ARTICLE - A poly(arylene ether) composition includes a styrenic polymer, a flame retardant comprising an organophosphate ester, and a poly(arylene ether)-polysiloxane block copolymer reaction product. The poly(arylene ether)-polysiloxane block copolymer reaction product includes a poly(arylene ether)-polysiloxane block copolymer and a poly(arylene ether) homopolymer. The composition is useful for forming molded articles, including photovoltaic junction boxes and connectors. The composition exhibits stiffness and a good balance of flame retardancy, impact strength, flow, and heat resistance. | 2013-01-31 |
20130030097 | ARTICLE, IN PARTICULAR A PNEUMATIC TYRE, HAVING AN EXTERNAL RUBBER MIXTURE COMPRISING A LANTHANIDE SALT - This invention relates to an article, in particular a pneumatic tire for a vehicle, comprising at least one external rubber mixture, in particular a tread, said external mixture comprising a rubber mixture consisting of at least one diene elastomer such as BR, SBR or NR, a reinforcing filler such as silica, a crosslinking system such as a vulcanization system, between 0.2 and 10 pce of an antioxidant, for example a substituted paraphenylenediamine, and between 0.2 and 10 pce of a lanthanide acetylacetonate such as a neodymium actylacetonate. The latter makes it possible to advantageously reduce the consumption of antioxidant during the thermal oxidizing aging of the composition and hence of the external mixture. | 2013-01-31 |
20130030098 | SUPERHYDROPHOBIC COMPOSITIONS - The present invention relates to a stable dispersion comprising at least, but not limited to, three key elements that, when combined accordingly, can achieve the desired superhydrophobic results; the at least three elements being a hydrophobic component, nano-structured particles and water. | 2013-01-31 |
20130030099 | CARBON BLACK COMPOSITION AND USAGE THEREOF - An aspect of the present invention relates to a carbon black composition, which comprises carbon black; an alkane nitrile; and at least one organic solvent selected from the group consisting of methyl ethyl ketone and cyclohexanone. | 2013-01-31 |
20130030100 | SEMI-CRYSTALLINE POLYOLEFIN COMPOSITION, METHOD OF PRODUCING THE SAME, AND ARTICLES MADE THEREFROM - A semi-crystalline polyolefin composition comprising: a thermoplastic crystallizable polyolefin; and one or more di-alkyl bis-oxalamide compounds having the formula: | 2013-01-31 |
20130030101 | Copper Complexes Of Amino-Functional Organosilicon Compounds And Their Use - Copper complexes of aminoorgano group-containing organosilicon compounds exhibit high thermal stability and can be used to impart thermal stability to a wide variety of polymer compositions. The complexes are particularly useful as constituents of xerographic rollers and fuser oils, and are simply and economically prepared. | 2013-01-31 |
20130030102 | TIRE RUBBER COMPOSITION AND PNEUMATIC TIRE - The present invention provides a tire rubber composition which improves in fuel economy, processability, adhesion, and rubber strength in a balanced manner, and a pneumatic tire. The tire rubber composition includes: a rubber component; a plasticizer (a); and at least one of a resin and a plasticizer (b), the resin being at least one selected from the group consisting of aromatic petroleum resins, terpenic resins, and rosin resins. The plasticizer (a) has a glass transition point of −50° C. or lower. The resin and the plasticizer (b) each have a glass transition point of −40° C. to 20° C. The tire rubber composition includes, for each 100 parts by mass of the rubber component, 1 to 30 parts by mass of the plasticizer (a) and 1 to 30 parts by mass in total of the at least one of the resin and the plasticizer (b). | 2013-01-31 |
20130030103 | RUBBER COMPOSITION AND USE THEREOF - Provided is a rubber composition, which has excellent heat resistance, acid resistance, gas permeability resistance, and high-speed moldability, has low hardness and low counterforce, has excellent high-temperature compression set, and does not adhere to the metal of molds, etc. but is self-adhering with respect to organic resins. The rubber composition comprises: a predetermined ethylene/α-olefin/non-conjugated polyene copolymer [A]; a predetermined SiH group-containing compound [B-1] having two SiH groups per molecule and/or a predetermined SiH group-containing compound [B-2] having three SiH groups per molecule; and a predetermined methacrylic acid ester compound [C]. | 2013-01-31 |
20130030104 | RESIN COMPOSITION - An object of the invention is to provide a resin composition that exhibits sufficient oxygen absorption performance within a relatively short period after being placed in the presence of oxygen, even without including an oxidation catalyst such as a transition metal catalyst, and that furthermore suppresses the generation of malodor associated with oxygen absorption. The object is attained by providing a resin composition comprising an oxygen absorbing resin composition dispersed within a matrix resin, characterized in that the oxygen absorbing resin composition comprises a cyclized product of a conjugated diene polymer and a saturated fatty acid having 18 to 44 carbon atoms. | 2013-01-31 |
20130030105 | HEAT-DISSIPATING RESIN COMPOSITION USED FOR LED LIGHT HOUSING AND HEAT-DISSIPATING HOUSING FOR LED LIGHTING - Provided is a novel heat-dissipating resin composition used for an LED light housing, the composition having excellent heat dissipation, fire retardancy, insulation properties, and molding processability as well as low specific gravity and improved whiteness. Also provided is a heat-dissipating housing for LED lighting, the housing being molded using the heat-dissipating resin composition. Disclosed is a heat-dissipating resin composition used for an LED light housing, comprising: 100 parts by mass of a thermoplastic resin composition (X) comprising 40 to 65% by mass of a polyamide resin (A), 33.5 to 59.8% by mass of a metal-hydroxide-based fire retardant (B), and 0.2 to 1.5% by mass of a polytetrafluoroethylene resin (C); and 5 to 200 parts by mass of an inorganic filler (Y) comprising 5 to 100% by mass of boron nitride (D) and 0 to 95% by mass of an inorganic oxide filler (E), wherein thermal conductivity is equal to or greater than 1.0 W/m·K. Also, disclosed is a heat-dissipating housing for LED lighting, the housing being molded using the heat-dissipating resin composition. | 2013-01-31 |
20130030106 | HYBRID CLEAR MATTE PAINT COMPOSITION FOR A VEHICLE - Disclosed is a matte clear coat paint composition for a vehicle including a polymer resin for paint and a matting agent, the matting agent containing silica and talc. The disclosed matte clear coat paint composition for a vehicle reduces the amount of silica used as a matting agent, which is economically advantageous, in order to provide a matting effect equivalent to that of an existing matte clear coat paint compositions, and significantly reduces agglomeration of pigments, thereby providing a uniform application. Moreover, it is possible to prevent the occurrence of gloss due to friction with cloth, flannel, etc. and provide various textures by changing the type of talc. | 2013-01-31 |
20130030107 | Method for Making a Poly-lactic acid/Silica Composite - Disclosed is a method for making a poly-lactic acid/silica composite. At first, silica particles are aminated, thus providing aminated silica particles. Secondly, the aminated silica particles are mixed with poly-lactic acid. Then, the mixture is blended and extruded by two micro-screws, thus providing a poly-lactic acid/silica composite. Thus, the mechanical properties of the poly-lactic acid are improved without affecting the biodegradability of the poly-lactic acid. | 2013-01-31 |
20130030108 | CARBON BLACK, METHOD FOR PRODUCING CARBON BLACK, AND RUBBER COMPOSITION - Carbon black includes primary particles having an average particle size of 15 to 40 nm, microprotrusions having an average length of 2 to 10 nm being formed on a surface of the primary particles. A method for producing carbon black includes introducing an oxygen-containing gas and fuel into a fuel combustion zone, mixing and combusting the oxygen-containing gas and the fuel to produce a high-temperature combusted gas stream, introducing a raw material hydrocarbon in a first stage of a raw material introduction zone and introducing the raw material hydrocarbon and an oxygen-containing gas in a second stage of the raw material introduction zone while introducing the high-temperature combusted gas stream into the raw material introduction zone to produce a carbon black-containing gas which is introduced into a reaction termination zone while spraying a coolant. | 2013-01-31 |
20130030109 | COMPOSITE FORMED FROM A POLYAMIDE MOULDING COMPOSITION AND A VULCANIZED ELASTOMER - In a composite component assembled from at least one component piece comprising a polyamide moulding composition with at least one component piece comprising a vulcanized elastomer, the polyamide moulding composition comprises at least 40% by weight of a mixture of the following constituents: a) 60 to 99 parts by weight of polyamide and b) 1 to 40 parts by weight of a graft copolymer obtainable using the following monomers: a) 0.5% to 25% by weight, based on the graft copolymer, of a polyamine having at least 4 nitrogen atoms and also β) 75% to 99.5% by weight, based on the graft copolymer, of polyamide-forming monomers selected from lactams, ω-amino carboxylic acids and/or equimolar combinations of diamine and dicarboxylic acid, wherein the parts by weight of a) and b) sum to 100. The presence of the graft copolymer effectuates improved adherence between the component pieces. | 2013-01-31 |
20130030110 | AQUEOUS-DISPERSION-TYPE PRESSURE-SENSITIVE ADHESIVE COMPOSITION AND PRESSURE-SENSITIVE ADHESIVE SHEET - Provided is a water-dispersed pressure-sensitive adhesive composition useful for purposes of producing a pressure-sensitive adhesive sheet having high rough surface adhesiveness also in a good balance with the other properties, and so on. The pressure-sensitive adhesive composition comprises an acrylic polymer pA | 2013-01-31 |
20130030111 | RUBBER COMPOSITION FOR WINTER TIRE, AND WINTER TIRE - The present invention provides a rubber composition for a winter tire which improves in performance on ice and snow, wet grip performance, and abrasion resistance in a balanced manner, and also has favorable proccessability; and a winter tire including a tread produced using the rubber composition. The present invention relates to a rubber composition for a winter tire which contains predetermined amounts of natural rubber, butadiene rubber, aromatic oil, silica, and carbon black, and also contains a specific silane coupling agent that includes a linking unit A represented by the following formula (1) and a linking unit B represented by the following formula (2) and has a predetermined content of the linking unit B. | 2013-01-31 |
20130030112 | POLYCARBONATE RESIN COMPOSITION, METHOD FOR PRODUCING SAME AND MOLDED ARTICLE OF THIS RESIN COMPOSITION - To provide a polycarbonate resin composition excellent in the surface hardness, the heat resistance, the moldability and the flame retardancy. | 2013-01-31 |
20130030113 | POLYCARBONATE RESIN COMPOSITION, METHOD FOR PRODUCING SAME AND MOLDED ARTICLE OF THIS RESIN COMPOSITION - To provide a polycarbonate resin composition excellent in surface hardness and impact strength. | 2013-01-31 |
20130030114 | Non-Yellowing Low VOC Mineral Surface Enhancer - Low VOC mineral surface enhancer compositions are non-yellowing and contain a condensable aminoorgano-functional organopolysiloxane fluid, a condensable organopolysiloxane resin, and a condensation catalyst. The compositions provide a durable, color enhancing wet look to mineral surfaces to which they are applied. | 2013-01-31 |
20130030115 | Water-Dispersible Silicone Resins - A process for preparing an aqueous dispersion of a silicone resin is disclosed by reacting a mixture containing an alkylalkoxysilane and a cationic alkoxysilane to form a self dispersing silicone resin and subsequently combining the silicone resin with water to form the dispersion. The resulting dispersions are useful for forming coatings on various substrates that are essentially free of co-surfactants or volatile organic solvents. | 2013-01-31 |
20130030116 | FILM, RESIN COMPOSITION AND POLYMER - Provided is a film comprising a polymer that comprises a structural unit represented by the following formula (1), wherein at least part of the terminal structure of the polymer is at least one structure selected from the group consisting of structural units represented by the following formula (2) and structural units represented by the following formula (3). | 2013-01-31 |
20130030117 | METHOD OF MANUFACTURING POLYAMIDE AND CARBON NANOTUBE COMPOSITE USING HIGH SHEARING PROCESS - The present invention provides a method of manufacturing polyamide-carbon nanotube composites. The method includes mixing a polyamide composition including 0.01-1% by weight of carbon nanotubes using a shearing rate equal to or greater than 1000-4400 sec | 2013-01-31 |
20130030118 | PROCESS FOR OBTAINING LOW FREE MONOMER LEVELS IN A BLOCK COPOLYMER EMULSION PREPARED WITH (REVERSE) IODINE TRANSFER POLYMERISATION - A process for obtaining an aqueous emulsion comprising a block copolymer by the solution polymerisation of vinyl monomers to obtain block [B] in the presence of a) a radical precursor; and b) an iodine atom containing block [A]; where block [A] and [B] together comprise 0 to 2 wt % of methacrylic acid; where block [A] and block [B] together comprise ≧2.5 wt % of vinyl monomers bearing ionic or potentially ionic water-dispersing groups not including methacrylic acid; and performing a post polymerisation reaction on the block copolymer emulsion obtained in step II; and wherein said aqueous emulsion has a free vinyl monomer level <1000 ppm when having a solids content of ≧20 wt %. | 2013-01-31 |
20130030119 | POLYSACCHARIDE-GRAFTED POLYETHYLENIMINE AS A GENE CARRIER - The present invention discloses a gene carrier and the preparation method thereof. Chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form chrondroitin sulfate-methacrylate (CSMA), which is further covalently bound with polyethylenimine (PEI) via the Michael addition to produce a CSMA-PEI gene carrier. The CSMA-PEI gene carrier can effectively reduce the cytotoxicity of PEI and enhance the transfection efficiency of PEI. | 2013-01-31 |
20130030120 | AMPHIPHILIC MULTI-ARM COPOLYMERS AND NANOMATERIALS DERIVED THEREFROM - The present invention relates to polymers, nanomaterials, and methods of making the same. Various embodiments provide an amphiphilic multi-arm copolymer. The copolymer includes a core unit and a plurality of amphiphilic block copolymer arms. Each block copolymer arm is substituted on the core unit. Each block copolymer arm includes at least one hydrophilic homopolymer subunit and at least one hydrophobic homopolymer subunit. In some examples, the copolymer can include a star-like or bottlebrush-like block copolymer, and can include a Janus copolymer. Various embodiments provide a nanomaterial. In some examples, the nanomaterial can include Janus nanomaterials, and can include nanoparticles, nanorods, or nanotubes. The nanomaterial includes the amphiphilic multi-arm copolymer and at least one inorganic precursor. The inorganic precursor can be coordinated to at least one homopolymer subunit of one of the amphiphilic block copolymer arms to form the nanomaterial. Various embodiments also provide methods of making the copolymer and the nanomaterial. | 2013-01-31 |
20130030121 | METHODS OF CONSTRUCTING ALKENE-BASED HOMOPOLYMER POLYOLEFINS HAVING REDUCED CRYSTALLINITY - The invention is a novel family of polyolefins characterized by chain-walking defects of the type that add extra backbone carbons per monomer. These polyolefins display a large decrease in crystallinity relative to polyolefins known in the art. Specifically, the reduction in crystallinity is much greater than for earlier polypropylenes with a matched content of stereo or 1-alkene type defects. The claimed polyolefins can be an alkene-based homopolymer. The defects in the polyolefin backbone are generated by a chain walking mechanism in which three or more carbons per monomer are added to the polymer backbone instead of two, as in conventional polymerization or copolymerization methods of alpha olefins. The novel polyolefins can be used in applications such as plastic wrapping, thin films, co-extrusion layers or molded parts in the absence of polymer blending or copolymerization. The cost of materials production can be reduced. | 2013-01-31 |
20130030122 | ELASTOMERS CROSSLINKED BY POLYLACTIC ACID - A composition is provided, which comprises chains comprising a first graft copolymer of a first elastomer and a poly(L-lactic acid), and chains comprising a second graft copolymer of a second elastomer and a poly(D-lactic acid). At least some of the poly(L-lactic acid) and poly(D-lactic acid) crosslink the chains. Poly(L-lactic acid) and poly(D-lactic acid) may form stereocomplexes that crosslink the chains. The chains may be crosslinked by crystalline structures formed from at least some of the poly(L-lactic acid) and poly(D-lactic acid) in discrete regions. The crosslinked chains may form a matrix. In a method of forming the composition, the first and second graft copolymers are mixed, such as by melt blending or solution casting, to form the composition. The graft copolymers may be formed by a “grafting-though” or “grafting-from” process. The composition may be useful under a relatively wide range of temperatures. | 2013-01-31 |