05th week of 2009 patent applcation highlights part 43 |
Patent application number | Title | Published |
20090029314 | Apparatus and method for vertical positioning of dental implants - A positioning device is used to place an implant in the proper vertical position within the soft tissue and bone, provide space for subsequent procedures, and create a proper emergence profile for the final restoration. The lower portion of the positioning device has substantially the same outer shape as that of the implant but without external screw threads or other mechanical features for anchoring the implant in the jawbone. After the hole is countersunk, the depth of the hole in the jawbone is increased incrementally and checked with the positioning device for collar engagement and location of the margin within the gum tissue and bone. After the proper vertical position is attained, a special countersink bur may be used to create needed space around the implant margin and provide a proper crown emergence profile. | 2009-01-29 |
20090029315 | METHOD FOR MANUFACTURING DENTAL IMPLANT AND DENTAL IMPLANT - A dental implant capable of reliably preventing elution of metal when the dental implant is applied within an oral cavity and capable of reliably preventing occurrence of mismatching (bumpy occlusion or the like) when the dental implant is fixed in place, and a method for manufacturing the dental implant are provided. In the method for manufacturing a dental implant including an abutment, the abutment is manufactured through the steps including a titanium molded body production step for molding a titanium molded body composition to obtain a titanium molded body, an assembling step for assembling the titanium molded body and a ceramic member together to obtain an assembled body, a degreasing step for degreasing the assembled body so that the titanium molded body is transformed into a titanium degreased body, and a sintering step for sintering the assembled body to transform the titanium degreased body into a titanium member so that the titanium member is firmly fixed to the ceramic member. | 2009-01-29 |
20090029316 | Magnetically implantable prosthetic device and method to shorten healing time, enhance bone fusion, and retard bacterial growth - Disclosed is a prosthetic implant comprising an implantable magnetic base structure that supports or couples with a prosthetic suprastructure for implantation in a mammal to fulfill a prosthetic need. The implantable base more quickly fuses with surrounding tissue or bone with the aid of a magnetic field. The suprastructure abuts and is supported by the implantable base, and each comprises a biocompatible magnetic material to establish a magnetic field in the region of the tissue surrounding the implantable base. An anchoring arrangement may be employed to fasten the suprastructure to the base. Together, the magnetic base, suprastructure, and/or anchoring arrangement are positioned relative to each other to concentrate a magnetic field in the region of the implant in order to facilitate fusion of the base structure with surrounding bone or tissue. Advantageously, the magnetic field shortens the healing time and retards bacterial growth whereby to quickly fuse the base structure with the surrounding bone or tissue. | 2009-01-29 |
20090029317 | METHOD FOR MANUFACTURING DENTAL IMPLANT AND DENTAL IMPLANT - A dental implant capable of reliably preventing elution of metal when the dental implant is applied within an oral cavity and capable of reliably preventing occurrence of mismatching (bumpy occlusion or the like) when the dental implant is fixed in place, and a method for manufacturing the dental implant are provided. In the method for manufacturing a dental implant including an abutment, the abutment is manufactured through the steps including a titanium molded body production step for molding a titanium molded body composition to obtain a titanium molded body, a ceramic molded body production step for molding a ceramic molded body composition to obtain a ceramic molded body, an assembling step for assembling the titanium molded body and the ceramic molded body together to obtain an assembled body, a degreasing step for degreasing the assembled body so that the titanium molded body is transformed into a titanium degreased body and the ceramic molded body is transformed into a ceramic degreased body, and a sintering step for sintering the assembled body to transform the titanium degreased body into a titanium member as a sintered body and to transform the ceramic degreased body into a ceramic member as a sintered body so that the titanium member and the ceramic member are firmly fixed and joined together. | 2009-01-29 |
20090029318 | DENTAL IMPLANT AND METHOD FOR MANUFACTURING DENTAL IMPLANT - A dental implant capable of reliably preventing elution of metal when the dental implant is applied within an oral cavity and capable of reliably preventing occurrence of mismatching (bumpy occlusion or the like) when the dental implant is fixed in place, and a method for manufacturing the dental implant are provided. In the method for manufacturing a dental implant including an abutment, the abutment is manufactured through the steps including a titanium molded body production step for molding a titanium molded body composition to obtain a titanium molded body having one of male and female thread portions, a ceramic molded body production step for molding a ceramic molded body composition to obtain a ceramic molded body having the other thread portion which makes thread coupling with the one thread portion, an assembling step for assembling the titanium molded body and the ceramic molded body together so that the one thread portion makes thread coupling with the other thread portion, to obtain an assembled body, a degreasing step for degreasing the assembled body, and a sintering step for sintering the assembled body thus degreased. | 2009-01-29 |
20090029319 | COMPONENTS FOR PERMANENT REMOVABLE AND ADJUSTABLE DENTURES AND BRIDGES - A locking cap for dental implants embedded in hard dental tissue, such as tooth stubs or bones. The locking caps are ovoidal in plan view and may be formed of materials, such as non-adherent polymers, that are rigid, but softer than the material of the dental implant. | 2009-01-29 |
20090029320 | Extracoronal Attachment and Method for the Production Thereof - The extracoronal attachment comprises a female part ( | 2009-01-29 |
20090029321 | METHOD FOR MAUFACTURING DENTAL IMPLANT AND DENTAL IMPLANT - A dental implant capable of reliably preventing elution of metal when the dental implant is applied within an oral cavity and capable of reliably preventing occurrence of mismatching (bumpy occlusion or the like) when the dental implant is fixed in place, and a method for manufacturing the dental implant are provided. In the method for manufacturing a dental implant including an abutment, the abutment is manufactured through the steps including a ceramic molded body production step for molding a ceramic molded body composition to obtain a ceramic molded body, an assembling step for assembling a titanium member and the ceramic molded body together to obtain an assembled body, a degreasing step for degreasing the assembled body so that the ceramic molded body is transformed into a ceramic degreased body, and a sintering step for sintering the assembled body to transform the ceramic degreased body into a ceramic member so that the ceramic member is firmly fixed to the titanium member. | 2009-01-29 |
20090029322 | Use of Stem Cells, Method of Tissue Engineering, Use of Dental Tissues and Tooth Biological Substitute - The present invention is related to the use of stem cells of an animal species for obtainment of biological tooth substitute, in whole or in parts, to be implanted in organism of the same animal strain, wherein said stem cells can be adult cells. The present invention still aims to develop a method of tissue engineering for culturing cells capable to form dental tissue for production of a tooth biological substitute. The said dental tissue can used for the treatment of people suffering from loss, fail or lack of these tissues, and also for cosmetic use of those tissues for a morphological modifying on a patient dentition, for example, the patient may desire to, or need to, have a bigger or smaller dentition for any aesthetic reason. | 2009-01-29 |
20090029323 | Retractable interproximal brush - There are provided a device and a method for cleaning teeth. The device comprises a brush, a shaft connected to the brush, a neck surrounding the shaft along a substantial portion of the length of the shaft, and a controller coupled to the shaft at the end of the shaft opposite the brush, the controller being mounted at the base of the neck so as to be movable between a first position that extends the brush away from the neck, and a second position that retracts the brush towards the neck. The method comprises inserting, between adjacent teeth, a device having a brush, a controller and a handle, the controller for effecting movement of the brush in a direction generally perpendicular to the handle, and keeping the handle generally stationary while moving the controller up and down to move the brush along front-to-back and back-to-front paths between the adjacent teeth. Moving the controller may occur via pressure from a user's finger, or via force from a motor in the device. In some cases, the method includes vibrating the brush while it is moved along the front-to-back and back-to-front paths between the adjacent teeth. | 2009-01-29 |
20090029324 | Methods and Devices for Fixed Dental Restoration - This invention relates to methods and devices for restoring teeth using fixed restorations. In particular, the invention provides a system, kit, and devices for the management of interproximal areas for traditional cementation and/or bonding of dental crowns, onlays, inlays, veneers and bridges. In the method, a barrier is positioned in contact with the tooth being restored and an adjacent tooth to cover a section of the tooth being restored and to create separation of the tooth being restored and the adjacent tooth. Cement is applied to the first mating surface of the fixed restoration and/or to the second mating surface of the tooth, and the first mating surface of the fixed restoration and the second mating surface of the tooth are positioned adjacent each other to seat the fixed restoration on the tooth. The barrier covers a section of the tooth being restored to prevent cement from bonding to the section of the tooth. This eliminates the need to remove hardened cement from this section of the tooth. | 2009-01-29 |
20090029325 | VIRTUAL LOCOMOTIVE SIMULATION SYSTEM AND METHOD - A complete hardware and software railroad training system gives the trainee a hands-on operators experience in a safe and productive classroom environment. The system and method combines a complete virtual simulation of a yard and the associated equipment with a cost-effective Operator Control Unit (OCU) to fully address Remote Control Operation (RCO), including equipment handing, yard familiarization, rules and safety training. A simulated locomotive training system according to the invention comprises a computer system generating a display of an avatar in a simulated railroad environment including a virtual locomotive and associated equipment. The OCU, a hand-held unit in communication with the computer system, includes one or more video-game or “game-pad” type controls, enabling a user to manipulate the avatar in the simulated railroad environment. The controls may be joystick controllers, allowing a user to navigate, view and select objects and actions in the simulated railroad environment without the user's hands having to leave the OCU. Right and left controls, each operated by one finger on each of a user's hands, respectively direct the movement of the avatar in the simulated railroad environment and change the view of the avatar in the simulated railroad environment. | 2009-01-29 |
20090029326 | Integrated method of teaching cooking and reinforcing cooking skills - Disclosed is a system and method that can enable a user to understand the basis of one or more methods of food preparation through a learning construct that incorporates a teaching of foundational components with a teaching of a foundational process. The disclosed device also comprises a construct that can reinforce and/or strengthen the user's learned basis of understanding of components and processes beyond recipe replication. The reinforcement construct seeks to further instill the understanding of the technique being taught through a variety of tools, such as by the use of recipes, tables arranging possible ingredients, guides, charts, definitions, instructions, tips, pairings, etc. | 2009-01-29 |
20090029327 | EDUCATIONAL GAME EMPLOYING CATEGORIES - A game serving as a tool for facilitating the education of elementary students in learning proper categorization of learning elements. The game includes a plurality of station markers suitable for being arranged physically in sequence, with each station marker representing a corresponding education category. The game further includes a plurality of tokens, each of the tokens including indicia representative of an item belonging to one of the educational categories. Each of the plurality of station markers includes a receiving area for receiving tokens from among the plurality of tokens. | 2009-01-29 |
20090029328 | DEVICE AND METHOD FOR COMPUTER-ASSISTED LEARNING - A method for the computer-assisted learning of orthography, the method includes executing the following steps by a data processing system:
| 2009-01-29 |
20090029329 | Computer keyboard overlay - In one embodiment, the invention provides a keyboard overlay adapted to indicate which one of a plurality of menu commands provided by a particular software application is invoked when an alphanumeric key is pressed together with a modifier key on a computer keyboard. In this embodiment, the keyboard overlay has a portion overlaying the modifier key and displaying a predetermined color thereby associating the color with the modifier key. The keyboard overlay has a portion overlaying the alphanumeric key and displaying the predetermined color together with closely associated indicia identifying the menu command. More complex arrangements are described that indicate keyboard equivalents that involve pressing an alphanumeric key together with more than one modifier key. | 2009-01-29 |
20090029330 | Toddler Device - A toddler device according to the present invention includes a base having a generally planar upper surface and defining a plurality of receiving holes. Further, the toddler device includes a set of posts, each post having an upper end and a lower end with a configuration complementary to a configuration of at least one of the receiving holes. Each post is padded, may include a liquid resistant surface, and is supported in a vertical configuration when received in a respective receiving hole. In addition, an entertainment element is coupled to respective post upper ends for interesting a toddler and encouraging the toddler to stand. | 2009-01-29 |
20090029331 | Active cutaneous technology - Active cutaneous technology to emulate the cutaneous characteristics of skin in medical training and other applications. Skin color changes are implemented with paint-on, electrically tunable, reflecting material that can conform to a mold, such as a manikin body or consumer product, and will enable the device to simulate skin. For example, skin colors associated with bruises, blue skin or cyanosis, redness from carbon monoxide poisoning or over radiation, and yellow skin from jaundice. Skin texture changes (e.g., goosebumps, rashes, and poxes) are established using tunable topological polymer films that grow in predetermined directions. Hair-raising, or piloerections, are accomplished with polymer-MEMS with varying thermal expansion coefficients on either side of a hair fiber due to anisotropic molecular alignment. These technologies are integrated, addressable and programmable through a control system. | 2009-01-29 |
20090029332 | External defibrillator training apparatus and method - A training apparatus ( | 2009-01-29 |
20090029333 | BODY PART MODEL WITH PULLOUT TABS - A body part model for a model body part of a human or other animal. The model includes a pullout tab. A base portion has one or more slots therein to accept the pullout tab with the pullout tab having a major surface thereon to display indicia that relate to the model body part. | 2009-01-29 |
20090029334 | CLASSROOM INSTRUCTIONAL TOOL - A classroom instructional tool allows an instructor to present a multimedia presentation on the tool while writing commentary on the same tool. The classroom instructional tool comprises of a front shell, a rear shell, attached to the front shell, a flat panel monitor attached to one of the sides of the rear shell, a computer housed within the other side of the rear shell, an internal whiteboard mounted on the front shell, an external whiteboard movably mounted on the front shell at a superior position than the internal whiteboard, and a camera attached to the rear shell at a position that is between one of the sides of the monitor and one of the sides of the rear shelf. The monitor, computer and the camera form a system of connectivity between them. The system of connectivity might be hardwired or wireless. | 2009-01-29 |
20090029335 | Educational system and improved teaching method - An educational system and improved method for teaching students using lessons taught by both a live teacher and by recorded multimedia presentations. The teacher teaches a lesson to the students, and then, divides the students into subgroups assigned to different workstations. Each workstation can include a different but related recorded lesson stored on a recording medium and at least one recording playback device for playing audio and video recordings. After the live lesson, the students begin the recorded lessons at their assigned workstations. The students are required to watch and listen to a recorded lesson and are rotated among workstations to view and listen to each recorded lesson. To determine each student's mastery of the lesson, the students are tested on the subject matter presented by the recorded lesson. Students who fail to meet a predetermined level of performance on the test are required to repeat the lesson. | 2009-01-29 |
20090029336 | AUTOMATIC FORM CHECKING AND TRACKING - A method for checking forms can include retrieving user responses to entries from a hardcopy of a form, comparing at least a portion of the retrieved responses to appropriate responses for the entries specified in a stored template for the form, generating indicia responsive to the comparing step locating inappropriate responses on the hardcopy, identifying a user associated with the hardcopy; and storing the results of the comparison in a location associated with the identified user. | 2009-01-29 |
20090029337 | Compact personal presentation coach - Method and apparatus are disclosed for a coach to be used in creating an optimal personal presentation. A unique, iconic symbol is displayed on the outside of a compact information display structure to specify a particular type of individual with distinguishing characteristics who is to use the personal presentation coach. The coach targets a specific component of personal presentation, such as clothing, make-up or business etiquette, and optionally, specific situations in which the coach will be used. The coach displays information in small conveniently accessible blocks or frames, each block easily assimilated by a user. Several embodiments for the physical structure of the coach are disclosed, including flat or multi-folded sheets, a fan, a flip book, a slider, a multi-layered wheel and digitally-created displays in a compact digital display device. | 2009-01-29 |
20090029338 | DISPLAY BOARD ASSEMBLY - A display board assembly includes a substrate having a first edge and a second edge, and a non-fabric bulletin board sheet including a first edge portion wrapped around the first edge of the substrate to at least partially cover the first edge of the substrate and a second edge portion wrapped around the second edge of the substrate to at least partially cover the second edge of the substrate. | 2009-01-29 |
20090029339 | Early Alert System and Method for Identifying and Assisting Students in Need at an Educational Institution - The present invention is a system and method that proactively identifies a student in need at an educational institution. The system allows for the educational institution to connect with the student, gather information, and provide assistance. Student needs that may be addressed are various and include academic, social, emotional, and spiritual. Because student needs are addressed in a timely and effective manner, the present invention may be used as a tool to increase retention rates at the educational institution. | 2009-01-29 |
20090029340 | Cryoprotective Compositions and Methods of Using Same - A cryoprotective composition which comprises nanostructures, liquid and at least one cryoprotective agent is provided. | 2009-01-29 |
20090029341 | Sample Support and Sample Store, Especially For the Cryopreservation of Biological Samples - A sample support ( | 2009-01-29 |
20090029342 | Medium and method for preserving platelets, red blood cells, and other non-nucleus cells and platelets-containing composition - The present invention provides a platelet-containing composition prepared by contacting platelets with a medium for preserving. The medium comprises anticoagulant, cryoprecipitate and thrombin. The present invention also provides a method for long-term preservation of platelets, comprising the steps of: (a) adding an anticoagulant, cryoprecipitate, thrombin in normal saline; (b) adding a platelet-containing medium into the solution formed in step (a); and (c) lyophilizing the platelet-containing solution formed in step (b). Moreover, the present invention yet provides a medium for preserving non-nucleus cells. | 2009-01-29 |
20090029343 | Methods for isolation and analysis of sialylated and phosphorylated peptides - Changes in sialylation of cell surface or plasma proteins are often associated with various cancers and other disease conditions Provided are methods of detecting biomarkers of conditions associated with a change of sialylation status. Sialylated peptides are first isolated from biological and other samples by loading onto titanium dioxide (TiO2) or zirconium dioxide (ZrO2) stationary phase under acidic conditions in a solution comprising at least 20% organic phase and at least about 6.5 mM of substituted aromatic carboxylic acid, or, alternatively, at least about 1 mM short chain, non-aromatic, hydroxylated carboxylic acid. Sialic acid containing proteins can then be eluted from loaded stationary phase material by exposure to an alkaline solution having pH of 9.0 or greater, preferably at least 10.5. Sialylated peptides isolated by the methods provided can then be analysed by mass spectrometry to identify patterns of sialylation across a sialiome (the entire complement of sialic acid containing peptides in a biological sample) and/or to identify proteins in a sample that are sialylated or that show changes in sialylation status between two or more different samples. In preferred embodiments, sialylated peptides from control and patient samples can be differentially isotopically labelled and compared in a single mass sprectrometry experiment. Also provided are specific biomarkers of bladder cancer. The methods for isolating and analysing sialylated proteins can also by applied to phosphorylated proteins. | 2009-01-29 |
20090029344 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators - Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials. | 2009-01-29 |
20090029345 | MODULATING SKELETAL MUSCLE - Methods of identifying skeletal muscle activators are provided. Methods of activating skeletal muscle using skeletal muscle activators are also provided. | 2009-01-29 |
20090029346 | Detection of human papilloma virus - An assay for detecting HPV comprising treating the viral nucleic acid with an agent that modifies cytosine to form derivative viral nucleic acid, amplifying at least a part of the derivative viral nucleic acid to form an HPV-specific nucleic acid molecule, and looking for the presence of an HPV-specific nucleic acid molecule, wherein detection of the HPV-specific nucleic acid molecule is indicative HPV. | 2009-01-29 |
20090029347 | Method for Identifying Multiple Analytes Using Flow Cytometry - The present disclosure is directed to a method of using antibodies attached to different types of microspheres against different antigens located within a biological sample. Optical and electronic particle detection may be used to separate the microspheres via flow cytometry, allowing the subsequent measurement of multiple analytes in a single sample of body fluid by separating and gating such analytes based on the type of microsphere to which the analyte is coupled. According to the present disclosure, various biological components may be attached to microspheres of different volumes, shapes, conductivity, densities, and/or colors to detect biological components by gating on the type of microsphere and analyzing the biological component attached thereto. | 2009-01-29 |
20090029348 | Kit for Detecting the Antibody of HCV and Its Preparing Method - A kit and its preparing method concerning dual-antigen sandwich method are used for detecting the antibody against HCV, and its detecting mode is ‘carrier-first antigen-antibody against HCV to be detected-second antigen-marker-distinguishable signal’. The kit ant its preparing method characterize in that the second antigen is the complex of a HCV and a tag. | 2009-01-29 |
20090029349 | Novel Applications of Acridinium Compounds and Derivatives in Homogeneous Assays - Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus. | 2009-01-29 |
20090029350 | RAPID DIAGNOSTIC METHOD FOR DISTINGUISHING ALLERGIES AND INFECTIONS AND NASAL SECRETION COLLECTION UNIT - A method for clinical scoring that involves evaluating certain parameters found in nasal secretia is disclosed. Contact of a nasal secretion with indicators for pH, protein content, leukocyte esterase activity, nitrite content, eosinophil content and/or TAME esterase activity permits diagnosis and differentiation between allergic, bacterial and viral conditions. | 2009-01-29 |
20090029351 | METHOD OF MEASURING HUMAN CYP3A INDUCIBILITY - A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that a non-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being an adenovirus which is used as a vector and engineered by incorporating thereto a detectable reporter gene and at least 3 human PXR binding regions falling within an untranslated region of a human CYP3A gene, and virus (B) being an adenovirus which is used as a vector and engineered by incorporating thereto a human PXR cDNA; and subsequently expression level of the reporter gene is determined in the non-human animal or the cultured human cells. | 2009-01-29 |
20090029352 | Method for detecting the Presence of A Nucleic Acid in A Sample - An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step. | 2009-01-29 |
20090029353 | MOLECULAR DETECTOR - Described herein are embodiments of a method and device comprising an electronic charge detector capable of detecting the presence of small quantities of electric charge generated through a universal signal generation process that is configured to detect any biological agents and biomolecular targets of interest. Electric charge results from signal molecules binding to affinity molecules that are attached to a detection surface. Electronic circuits are configured to detect the induced electric charges on the detection surface. Additional electronic devices then process useful quantitative data regarding specific biomolecular interaction events. | 2009-01-29 |
20090029354 | Method on clinical applications in head neck cancer by using DSG3 molecule for predicting malignant degree of cancer, serving as a molecular target and using RNA jamming sequence on inhibition-specific of DSG3 expression - The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that DSG3 overexpression is relates to size, depth and migration of tumor. Therefore, DSG3 overexpression is capable for using in clinical applications, determining malignant degree of tumor, serving as molecular target in Head Neck Cancer (HNC). Moreover, a jamming sequence, RNA, is designed to act on DSG3 mRNA and is effective inhibition-specific DSG3 expression, and then inhibits cell growth, invasion and migration in HNC. | 2009-01-29 |
20090029355 | Abnormalities of Phosphatase 2A (PP2A) for Diagnosis and Treatment of Alzheimer's Disease - This invention relates to methods of diagnosing Alzheimer's disease and methods of screening for compounds for the treatment or prevention of Alzheimer's disease. The methods are based upon newly discovered differences in protein phosphatase 2A (PP2A) function and related molecular events in Alzheimer's disease cells compared to control cells. In one embodiment, differences in basal PP2A gene expression in Alzheimer's cells are compared to controls. In another embodiment differences in PP2A protein and enzyme activity are compared in test and control cells. In another embodiment differences in response to substances that inhibit PP2A function are compared. Still another embodiment detects differences in the subcellular distribution of phosphorylated Erk1/2, a substrate of PP2A, in normal and Alzheimer's disease cells. The detection of Alzheimer's disease-specific differences in PP2A function and related events in peripheral tissues provides the basis for highly practical and efficient tests and diagnostic test kits for the early diagnosis of Alzheimer's disease, as well as providing a biochemical basis for identifying therapeutic targets for drug development. | 2009-01-29 |
20090029356 | Corynebacterium glutamicum genes encoding novel proteins - Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from | 2009-01-29 |
20090029357 | Method for diagnosing cancer using cancer-associated deletion gene marker - It is an object of the present invention to provide a novel method for diagnosing cancer by discovering a cancer-associated gene which could not be detected by a conventional technique, and detecting deletion, mutation, or an abnormal expression level of such cancer-associated gene. The present invention provides a method for diagnosing cancer which comprises a step of detecting deletion of the GMDS, ANKRD15, TEK, or EBI2 gene in a test sample by using DNA containing all or part of said gene. | 2009-01-29 |
20090029358 | Methods and Compositions for the Diagnosis and Treatment of Schizophrenia - Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the treatment of such disorders. | 2009-01-29 |
20090029359 | DIAGNOSTIC METHODS FOR EARLY CANCER DETECTION - The present disclosure is directed to compositions and methods for detecting signs of telomere dysfunction as diagnostic indicators of metastatic disease. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect elevated expression of TRK2 protein or detect the presence of telomere fusions as an early diagnostic test for cancerous or pre-cancerous cells. In one embodiment the methods of the present disclosure are used to diagnose the existence of, or assess the risk of, breast cancer in an individual. | 2009-01-29 |
20090029360 | Nucleic Acid Amplification and Detection of Mycobacterium Species - Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus | 2009-01-29 |
20090029361 | GROWTH DIFFERENTIATION FACTOR-7 - The present invention provides methods of using polynucleotides that hybridize specifically with a polynucleotide encoding GDF-7 to identify GDF-7 in a sample. | 2009-01-29 |
20090029362 | GENE COPY NUMBER PROFILING - The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source. | 2009-01-29 |
20090029363 | METHOD OF SELECTION BY TWO-DIMENSIONAL SEPARATION, OF NUCLEIC ACIDS THAT BIND TO A TARGET WITH HIGH AFFINITY - The invention relates to a method of selection, by two-dimensional separation, of nucleic acids that bind to a target molecule with high affinity from a mixture of nucleic acids, including the following steps: a) subjecting the mixture of nucleic acids to a physico-chemical separation step, thereby obtaining a set of mixed fractions containing the nucleic acids, a run parameter window being associated with every mixed fraction containing the nucleic acids, b) contacting a mixed fraction containing the nucleic acids with the target molecule, thereby obtaining a binding mixture containing nucleic acid/target molecule complexes, c) subjecting the binding mixture from step b) to the same physico-chemical separation step as in step a), thereby selecting nucleic acid/target molecule complexes whose run parameters are outside of the run parameter window. | 2009-01-29 |
20090029364 | Specific multiplex analysis of nucleic acids - A method of detecting the presence or absence of variant nucleotides within target nucleic acid sequences, said method comprising the use of at least one pair of target-specific amplification primers capable of hybridizing to target nucleic acid sequences, and the use of at least one set of diagnostic primers, each set consisting of at least two types of diagnostic primers capable of hybridizing to corresponding target nucleic acid sequences 3′-relative to said amplification primers, such that each set of diagnostic primers is semi-nested relative to the corresponding pair of amplification primers. Additionally, the use of said method for genotyping, for diagnostic screening, for assaying the cytosine methylation status and for quantification of nucleic acids is disclosed. | 2009-01-29 |
20090029365 | NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF COLON CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with colon cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human colon cancers are provided. | 2009-01-29 |
20090029366 | METHODS OF IDENTIFYING MODULATORS OF HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS - Methods, including high-throughput methods, for identifying modulators of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. | 2009-01-29 |
20090029367 | POLYMORPHISMS IN PON1 ARE ASSOCIATED WITH ELEVATED ALANINE AMINOTRANSFERASE LEVELS AFTER XIMELAGATRAN OR TACRINE ADMINISTRATION - This invention relates to a method for administering a pharmaceutically useful anticoagulant drug to certain suitable patients and a method for identifying those patients suitable for receiving the drug. In particular, the invention surrounds the identification of an association between certain SNPs in the PON1 gene and susceptibility to increased levels of alanine aminotransferase (ALAT) following ximelagatran or tacrine administration. Thus, this invention relates to methods for predicting susceptibility to elevated ALAT following ximelagatran or tacrine administration and to methods for administering a pharmaceutically useful anticoagulant drug to certain suitable patients. | 2009-01-29 |
20090029368 | Method for determining the cell culture history of a cell unit labelled with more than one type of tag - The present invention relates in one aspect to a method for determining the cell culture history of a cell unit labelled with more than one type of tag comprising the steps of: (a) measuring one or more parameters of each tag that is used to label the cell unit; (b) identifying each tag in the cell unit; and (c) correlating the identity of each tag to the identity of the cell unit and/or the specific cell culture conditions to which the cell unit has been exposed. | 2009-01-29 |
20090029369 | GENETIC SELECTION SYSTEM TO IDENTIFY PROTEASES, PROTEASE SUBSTRATES AND PROTEASE INHIBITORS - The present invention concerns a tester protein for identifying and/or monitoring protease activity in a cellular assay suitable for high throughput screenings by growth selection, wherein the tester polypeptide is a non-regulatory protein carrying a protease cleavage sequence. Upon co-expression of the protease recognizing said cleavage sequence the tester protein is inactivated, which influences the growth and/or survival of the host cells under the chosen conditions. However, in the presence of protease inhibitor the growth phenotype is reversed. The system can be used to identify proteases, protease inhibitors, and protease cleavage sites. | 2009-01-29 |
20090029370 | REAL TIME NUCLEIC ACID DETECTION IN VIVO USING PROTEIN COMPLEMENTATION - The present invention relates to a method to detect nucleic acid molecules, such as RNA molecules in vivo using real time protein complementation methods. The invention further relates to methods for detecting nucleic acids, for example RNA in real-time in living cells with a high sensitivity, using a novel split biomolecular conjugate of the invention. | 2009-01-29 |
20090029371 | METHOD FOR DETERMINING VASOREACTIVITY - The present invention is generally directed to methods and materials for determining the genotype of a patient to predict the patient's vasoreactivity. More particularly, the present invention is directed to a method of determining the vasoreactivity of a subject, comprising: obtaining from a subject a sample comprising a nucleic acid sequence of the BMPR2 gene or amino acid sequence of the BMPR2 gene; determining the presence or absence of a non-synonymous mutation in the BMPR2 nucleic acid or amino acid sequence, and correlating the presence of a non-synonymous mutation with non-vasoreactivity or the absence of a non-synonymous mutation with vasoreactivity. | 2009-01-29 |
20090029372 | ADAM12 AS A BIOMARKER FOR BLADDER CANCER - The present inventors have shown that the gene and protein expression profiles of ADAM8, ADAM10 and ADAM12 in different grades and stages of bladder cancer. | 2009-01-29 |
20090029373 | METHOD FOR THE QUANTITATIVE DETECTION OF NUCLEIC ACIDS - Provided herein is a method for the quantitative detection of HHV-6 subtypes A and/or B based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5′-3′ nuclease activity. | 2009-01-29 |
20090029374 | SYSTEM AND METHOD FOR IDENTIFYING NETWORKS OF TERNARY RELATIONSHIPS IN COMPLEX DATA SYSTEMS - A system and method for identifying high order associations between variables in complex systems that is particularly useful where there is no correlation or weak correlation between variables due to the influence of a third variable, a ternary relationship. The ternary relationship describes how the variation in the pattern of association between a pair of variables, including its sign and strength, is mediated by a third variable. In one embodiment applied to gene expression data, the activity of pairs of correlated genes due to the activity of one or more third genes is shown. | 2009-01-29 |
20090029375 | GENETIC MODELS FOR STRATIFICATION OF CANCER RISK - The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of in multiple selected genes to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and family history are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment. | 2009-01-29 |
20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 2009-01-29 |
20090029377 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 2009-01-29 |
20090029378 | High sensitivity multiparameter method for rare event analysis in a biological sample - A sample of blood containing CTCs, or other cells of interest, is stained with fluorescent markers for image analysis and scanned to identify the presence and location within the cartridge of target cells or subcellular elements. A sample containing desired target cells or subcellular elements is then further processed, in part by photobleaching the sample, so that those same targets may be re-analyzed with additional biomarkers conjugated to the same or different fluorochromes using the same imaging criteria that were used for the initial analysis. The present invention has applications with targets such as circulating epithelial, cells, circulating tumor cells, circulating endothelial cells, leukocytes, lymphocyte subsets, cells containing an organelle or receptor of interest, cellular debris, disrupted cells and their debris, or any other formed element that might be captured and imaged. The invention provides a means to further interrogate individual targets of interest, especially when coupled with genetic analysis such as FISH. | 2009-01-29 |
20090029379 | GENETIC MARKERS FOR PROGNOSIS OF ANTIFOLATE TREATMENT EFFICACY - Methods and kits for predicting the efficacy of antifolate (e.g., methotrexate) treatment of rheumatoid arthritis by detecting polymorphisms, particularly single nucleotide polymorphisms, in adenosine pathway genes. | 2009-01-29 |
20090029380 | HUMAN MutY - A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed. | 2009-01-29 |
20090029381 | METHODS AND COMPOSITIONS FOR ANALYZING AHASL GENES - The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of wild-type AHASL alleles and mutant AHASL alleles that encode imidazolinone-tolerant AHASL proteins. The methods involve the use of PCR amplification and novel compositions comprising allele-specific and gene-specific primers to detect the presence of mutant and/or wild-type alleles present at the individual AHASL genes of a plant. Specifically, the methods and compositions are useful for analyzing the three AHASL genes of | 2009-01-29 |
20090029382 | CHARACTERIZATION OF A MEMBRANE ESTROGEN RECEPTOR - The present invention discloses the identification of a novel membrane associated estrogen receptor, termed mER. The membrane associated receptor is involved in rapid signal transduction. Amino acid sequences, nucleic acid sequences, vectors, and host cells are also discussed. Additionally, methods of detecting agonists and antagonists for the receptor are disclosed herein. | 2009-01-29 |
20090029383 | Polynucleotide Sequencing Method - The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal. | 2009-01-29 |
20090029384 | TECHNIQUES FOR RECORDING SIGNALS - The present invention provides techniques of recording signals. In one aspect of the invention, a method of recording a signal comprises the following steps. One or more errors are selectively introduced during synthesis of a polymer in response to the signal. The one or more occurrences of the one or more errors in the synthesized polymer are recorded. The synthesis of the polymer may comprise a polymer synthetase that can selectively introduce the one or more errors in response to the signal. A method for analyzing signals is also provided. | 2009-01-29 |
20090029385 | Molecular redundant sequencing - Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in sequence by incorporation processes that rely upon template dependent, polymerase mediated primer extension in the identification of the sequence of the template. | 2009-01-29 |
20090029386 | KIT FOR ENUMERATING MAMMALIAN CELL MICRONUCLEI WITH AN EMPHASIS ON DIFFERENTIALLY STAINING MICRONUCLEI AND THE CHROMATIN OF DEAD AND DYING CELLS - The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed. | 2009-01-29 |
20090029387 | METHOD FOR EFFECTIVELY MEASURING THE ACTIVITY OF CYTOTOXIC T LYMPHOCYTES IN HUMAN AND OUT-BRED ANIMALS - A method for measuring the activity of cytotoxic T lymphocytes (CTLs) includes preparing peripheral blood mononuclear cells (PBMCs) from blood of an animal; preparing mature dendritic cells by isolating monocytes from the PBMCs, differentiating the monocytes into dendritic cells for presenting an antigen molecule and pulsing dendritic cells with the antigen molecule to obtain the mature dendritic cells; preparing the CTLs as an effector cell by stimulating the PBMCs with the mature dendritic cells to activate and amplify the CTLs; preparing target cells by pulsing the PBMCs, monocytes or B cells with a cytoplasmic transduction peptide (CTP)-antigen complex generated by linking the antigen molecule of step (b) to the CTP; treating the target cells with the effector cells; and analyzing the lysis of the target cells. In addition, a kit for measuring the activity of cytotoxic T lymphocytes is provided. | 2009-01-29 |
20090029388 | Detection of Antibodies - The present invention relates to a method for detecting antibodies against a target antigen in a sample which comprises contacting the sample with labelled target antigen, subjecting the sample to immunoprecipitation to precipitate antibodies in the sample and detecting the presence of antibodies against the target antigen in the sample by means of the presence of labelled target antigen in the immunoprecipitate, wherein the labelled target antigen is a fusion protein comprising the target antigen and a fluorescent protein label and the presence of labelled target antigen in the immunoprecipitate is detected by means of the fluorescence of the fluorescent label. The method is particularly suitable for use where the target antigen is an autoantigen and can also be used to identify autoantigens implicated in a particular autoimmune disorder by screening serum samples from patients with a clinical phenotype indicative or suggestive of an autoimmune disorder and suitable controls. The target protein may be from the cys-loop acetyl choline receptor ion channel gene superfamily, the voltage-gated calcium, sodium or potassium ion channel gene superfamily, the glutamate receptor gene family, a receptor tyrosine kinase, or other membrane associated channels such as aquaporin gene family. | 2009-01-29 |
20090029389 | FLUORESCENT METAL ION INDICATORS WITH LARGE STOKES SHIFTS - The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength. | 2009-01-29 |
20090029390 | METHOD FOR QUANTITATIVE ANALYSIS OF INTERACTIONS BETWEEN HIF-1ALPHA C-TERMINAL PEPTIDES AND CBP OR p300 PROTEINS AND METHOD OF SCREENING INHIBITORS USING THE SAME - The present invention relates to a method for quantitative analysis of interactions between fluorescein-labeled HIF-1α (alpha) C-terminal peptides and cAMP-responsive element binding protein (CBP) or p300 proteins, and a method of screening inhibitors against the formation of HIF-1α-p300 or HIF-1α-CBP protein complexes using the above method. | 2009-01-29 |
20090029391 | REAGENTS AND METHODS FOR THE DETERMINATION OF PK/ADME-TOX CHARACTERISTICS OF NEW CHEMICAL ENTITIES AND OF DRUG CANDIDATES - Methods using colloidal conductive polymers, noble metal nanoparticles or of stable metal/conductive polymer composite colloids as reagents for at least the in vitro prediction of, if not the determination of, PK/ADME-tox properties of new chemical entities (NCEs) are provided. Also provided are kits that include the subject methods and reagents for application thereof. The salient characteristics of these methods and reagents pertaining to the present invention reside in the fact that the reactions in which they are involved are homogeneous, rapid, and proceed as “mix and read” processes. | 2009-01-29 |
20090029392 | MAGNETIC-NANOPARTICLE CONJUGATES AND METHODS OF USE - The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms. | 2009-01-29 |
20090029393 | METHOD FOR PREPARING ANTIBODIES SELECTIVE FOR ACTIVATING FC RECEPTORS - The present invention relates to a method for preparing an antibody selective for activating antibody Fc region receptors (FcRs) comprising an ITAM motif or motifs (immunoreceptor tyrosine-based activation motif), comprising the steps of obtaining monoclonal antibodies from a hybridoma, from a heterohybridoma or from any animal, plant or human cell line, replacing each of the His 310 and His 435 residues (Cabat numbering) of the Fc region of said antibody with a residue chosen from lysine, alanine, glycine, valine, leucine, isoleucine, proline, methionine, tryptophan, phenylalanine, serine or threonine, and then selecting the antibodies for which the binding to inhibitory FcRs comprising ITIM motifs (immunoreceptor tyrosine-based inhibition motif) is decreased by at least 30%, preferably by at least 50%, 70%, 80% or else by at least 90% relative to the same antibody having a natural Fc region. The present invention also relates to the use of an antibody derived from the method of the invention in the production of a medicament for use in particular in the treatment of cancer and of infectious pathologies. | 2009-01-29 |
20090029394 | Novel Assay for the Detection of an Antibody Bound to a Cell Membrane Receptor - This invention relates to the design of a novel immunoassay specific for the measurement of humanized antibody, Campath-1H, bound to the CD52 cell membrane receptor. The method can be used for pharmacokinetic studies and for monitoring purposes. The invention reveals improvements in higher specificities and sensitivities that can be obtained in relation to the conventionally used methods. | 2009-01-29 |
20090029395 | Methods for Detection of Chlamydia in Samples - This invention relates to assays for | 2009-01-29 |
20090029396 | Assay kit and antibody for human low molecular weight CD14 - The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid sequence at a position among the positions 1 to 68. An assay kit for human low-molecular-weight CD14 using the antibody and an assay method of the present invention, preferably a sandwich method, are able to quantitatively or qualitatively determine human low-molecular-weight CD14 with high sensitivity and specificity in a simple manner, so that they are useful for the diagnosis of a patient suffering from sepsis. | 2009-01-29 |
20090029397 | Method for Monitoring Tocolytic Treatment - A method of monitoring tocolytic therapy in a pregnant woman. The method comprises determining a first concentration of placental protein 13 (PP13) in a bodily substance of a woman who has not received treatment with a tocolytic agent, determining a second concentration of PP13 in a bodily substance of the pregnant woman after initiation of treatment with a tocolytic agent, and comparing the second concentration with the first concentration. Based on the comparison, it may be determined whether to continue, discontinue, or modify the tocolytic treatment. | 2009-01-29 |
20090029398 | Microbial ATP extraction and detection system - The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently elicit bioluminescent detection of ATP among a broad variety of different microorganisms using a common single-step reagent composition. Additional luminescence-based methods are provided for identifying other useful extracting agents or for screening compounds for their pharmaceutical or biological effects on microbial cells. | 2009-01-29 |
20090029399 | METHOD FOR RAPID DETERMINATION OF THIOPURINE METHYLTRANSFERASE ACTIVITY - This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination of TPMT activity in biological samples. | 2009-01-29 |
20090029400 | Pharmaceuticals and methods for treating hypoxia and screening methods therefor - Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions. | 2009-01-29 |
20090029401 | Method for detecting biofuel producing microbes - A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a detectable amount of bioalcohol. The culture medium is contacted with the assay solution to produce a colorimetric reaction to screen for a biofuel producing microbe. | 2009-01-29 |
20090029402 | Assessment of Biological or Chemical Samples - A method for monitoring consumption or release of a gaseous analyte such as oxygen by a liquid sample under investigation includes providing a cuvette ( | 2009-01-29 |
20090029403 | Sesnsor for detecting a toxic or hazardous gas mixture and operating method - A sensor for detecting a gas mixture which substantially comprises air and contains one or a plurality of gases that exhibit a disadvantageous effect on living organisms, comprising: a sensor chip composed of silicon for reading out at least one signal which is generated at a sensitive substance given the presence of one or a plurality of target gases in the measurement gas, a sensitive substance applied on the sensor chip, comprising living cells, which respond to target gas, a signal processing unit for evaluating the signals of the Si chip. | 2009-01-29 |
20090029404 | MODULATION OF AQUEOUS HUMOR OUTFLOW BY TARGETING VASCULAR-ENDOTHELIAL-CADHERIN IN SCHLEMM'S CANAL CELLS - The present invention provides methods of inhibiting cadherins between Schlemm's canal cells, to a patient suffering from glaucoma as well as screening for substances that inhibit cadherins between the Schlemm's canal cells. | 2009-01-29 |
20090029405 | LARGE STOKE SHIFT NIR DYES - A compound of the following formula: | 2009-01-29 |
20090029406 | Npy Y4 Agonist as Therapeutic Agent for Disease Accompanied by Intestinal Tract Dysfunction - The present invention has its object to provide an agent capable of ameliorating the intestinal tract dysfunction through a novel mechanism of action. It also has its object to provide a method for the evaluation of a compound, including the screening of the agent. A disease accompanied by intestinal tract dysfunction can be ameliorated or treated by using an NPY Y4 agonist as a therapeutic agent. A compound capable of ameliorating or treating a disease accompanied by intestinal tract dysfunction can be evaluated or screened by evaluating a compound targeting to an NPY Y4 receptor. | 2009-01-29 |
20090029407 | Systems And Methods For Analyzing And Manipulating Biological Samples - A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell. | 2009-01-29 |
20090029408 | Methods for Characterizing Cell Proximity - One aspect of the invention relates to a method of identifying cell adjacency in a coculture of cells. The method includes generating a first set of image data of the coculture of cells, the first set of image data comprising nuclear position data for each imaged cell; generating a second set of image data of at least a subset of the coculture of cells, the second set of image data comprising cell identifier data associated with a first cell type; generating a third set of image data of at least a subset of the coculture of cells, the third set of image data comprising cell identifier data associated with a second cell type; and identifying a group of cells in response to the nuclear position data, wherein each cell having the first cell type in the group is adjacent another cell in the group having the second cell type. | 2009-01-29 |
20090029409 | METHOD FOR DETERMINATION OF OXIDATIVE STRESS - Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration. | 2009-01-29 |
20090029410 | Lipases from Thermophilic Anaerobes - The inventors have identified polypeptides having lipase activity in anaerobic thermo-philic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate, which comprises treating the substrate with a particular lipase (a polypeptide having lipase activity). The invention also provides a lipase for use in the process and a polynucleo-tide encoding the lipase. | 2009-01-29 |
20090029411 | Biomaterial Capable Of Successively Performing A Solution/Gel Transition And Then A Gel/Solution Transition - The invention relates to a biomaterial which can successively carry out a solution/gel transition then a gel/solution transition with given kinetics, said biomaterial comprising at least one monomer which may form polymers, at least on enzyme which may decompose said polymers and, optionally, an enzyme which may form covalent bonds between said monomers. The invention further relates to a method for the production of said biomaterial. | 2009-01-29 |
20090029412 | SOLUBILITY TAGS FOR THE EXPRESSION AND PURIFICATION OF BIOACTIVE PEPTIDES - Peptide tags, referred to here as inclusion body tags, are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag. | 2009-01-29 |
20090029413 | Process for the manufacture of a composite material - The invention relates to a process for the manufacture of a composite materials comprising the steps of
| 2009-01-29 |