04th week of 2013 patent applcation highlights part 37 |
Patent application number | Title | Published |
20130022970 | Methods Of Classifying Biological Samples For Predicting Response To Tyrosine Kinase Inhibitor Treatment - Gene copy numbers of signaling components downstream of EGFR identify non-small cell lung cancer (NSCLC) patients with poor outcomes on 2nd/3rd line gefitinib therapy. | 2013-01-24 |
20130022971 | NON-THIOPURINE METHYLTRANSFERASE RELATED EFFECTS IN 6-MERCAPTOPURINE THERAPY - The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient at a polymorphic site in at least one gene selected from the group consisting of a xanthine dehydrogenase (XDH) gene, molybdenum cofactor sulfurase (MOCOS) gene, and aldehyde oxidase (AOX) gene. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a 6-mercaptopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in at least one of the XDH, MOCOS, and AOX genes. | 2013-01-24 |
20130022972 | OLIGONUCLEOTIDES AND METHODS FOR DETECTING LAVENDER FOAL SYNDROME - A method for detecting a genetic polymorphism associated with Lavender Foal Syndrome or a predisposition thereto in a subject, the method including screening a genomic material sample from the subject for the presence of at least one polymorphism in a MYO5A gene. | 2013-01-24 |
20130022973 | Multiplex Amplification for the Detection of Nucleic Acid Variations - Kits, primers, and methods are provided herein for detecting relative target source to reference source ratios in a biological sample, by distributing the biological sample into discrete subsamples, wherein the biological sample includes, a plurality of target molecules on a target source; and a plurality of reference molecules on a reference source; providing target primers directed to one or more of the plurality of target molecules and reference primers directed to one or more of the plurality of reference molecules; performing digital amplification with the target primers and the reference primers; and detecting the presence or absence of amplified target products with target probes and detecting the presence or absence of amplified reference products with reference probes, wherein the ratio of amplified target products to amplified reference products is indicative of a relative amount of target source to reference source in a biological sample. | 2013-01-24 |
20130022974 | DNA METHYLATION PROFILES IN CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to methylation levels of genes (e.g., in CGI islands of the promoter regions) as diagnostic markers and clinical targets for prostate cancer. | 2013-01-24 |
20130022975 | METHOD FOR DETECTING ARTERIOSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3 - An atherosclerotic disease such as myocardial infarction or angina pectoris is detected by analyzing a single nucleotide polymorphism on human chromosome 5p15.3, and by associating results of the analysis with the risk of the onset thereof. Examples of the single nucleotide polymorphism on human chromosome 5p15.3 include a nucleotide corresponding to the nucleotide at position 61 in the nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, and a polymorphism at a nucleotide which is in linkage disequilibrium with the above nucleotide. | 2013-01-24 |
20130022976 | HYPERTHERMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE - The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism. | 2013-01-24 |
20130022977 | METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES - The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus. | 2013-01-24 |
20130022978 | Measurement of Brain CDP-Diacylglycerol Synthase 1 Enzyme and Uses Thereof - Provided herein are methods of diagnosing depressive disorders in a subject by comparing a CDP-diacylglycerol synthase 1 enzyme activity or expression level to enzyme activity or expression level of CDP-diacylglycerol synthase 1 in a control subject. Also herein are methods of predicting therapeutic efficacy of an antidepressant drug in a subject with depressive disorders by monitoring enzyme activity or expression level of CDP-diacylglycerol synthase 1 in the subject. Further provided herein are methods of identifying a compound effective to treat or alleviate the symptoms of depression by monitoring enzyme activity or expression level of CDP-diacylglycerol synthase 1 in a tissue. Further provided are kits for diagnosing depressive disorders. | 2013-01-24 |
20130022979 | 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER - The present invention broadly claims a method for detecting cancer in an individual. The method comprises detecting a deletion in the nucleic acid sequence between residues 10743 and 12125 in mitochondrial DNA. The method comprises obtaining a biological sample from the individual; extracting the mitochondrial DNA (mtDNA) from the sample; quantifying the amount of mtDNA in the sample having a deletion in the nucleic acid sequence between residues 10743 and 14125 of the mtDNA genome; and comparing the amount of mtDNA in the sample having the deletion to at least one known reference sample. | 2013-01-24 |
20130022980 | RNA- AND DNA-COPYING ENZYMES - The present invention is directed to DNA polymerase fusion proteins with increased processivity and nucleic acid affinity. The invention includes a fusion protein comprising a nucleic acid-binding domain fused to a polymerase domain. The nucleic acid binding domain contains at least one nucleic acid binding motif, such as a DNA-binding motif or an RNA-binding motif. The nucleic acid binding domain preferably embodies an oligonucleotide/oligosaccharide binding (OB) fold, among other conformations. The invention further includes methods of synthesizing nucleic acids using the fusion proteins described herein. | 2013-01-24 |
20130022981 | NOVEL HUMAN LYSOSOMAL PROTEIN AND METHODS OF ITS USE - The gene associated and causative of classical late infantile neuronal ceroid lipofuscinosis (LINCL), CLN2, has been identified and characterized. The translation product of this gene is a novel protease and a deficiency in this activity results in LINCL. Identification of CLN2 will not only aid in the prevention of LINCL through genetic counseling but provides strategies and test systems for therapeutic intervention. In addition, further characterization of this previously unknown lysosothal enzyme may provide useful insights into other more common human neurodegenerative disorders. Finally, the utility of a general approach for determining the molecular bases for lysosomal disorders of unknown etiology has been demonstrated. | 2013-01-24 |
20130022982 | MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY - Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Pakinson disease and Chronic Traumatic Encephalopathy (CTE). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury. | 2013-01-24 |
20130022983 | Colon and Rectal Tumor Markers and Methods of Use Thereof - Newly identified proteins as markers for the detection of colon and rectal tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, as well as methods for tumor diagnosis and therapy using such ligands. | 2013-01-24 |
20130022984 | METHOD FOR THE NON-SPECIFIC ENRICHMENT OF MICROORGANISMS - The present invention relates to a method for the non-specific enrichment of microorganisms from complex starting materials, wherein the starting materials containing the microorganisms are brought in contact with cells of the innate immune system, the microorganisms are bound to the cells of the innate immune system and the binding complex is separated from the complex starting material. | 2013-01-24 |
20130022985 | EXAMINATION METHOD TO DETERMINE CONTRACTION OR ACTIVITY OF DISEASES RELATED IMMUNE SYSTEM OR JOINT SYSTEM - The present invention provides an examination method for determining the contraction or the activity of diseases related to immune system and/or joint system, comprising measuring the expression level of miRNA in a blood-derived or joint-derived fluid sample. The present invention is an examination method for determining the activity of diseases related to immune system and/or joint system, comprising: preparing blood-derived fluid samples collected over time, measuring the expression levels of at least an miRNA selected from SEQ ID NOS: 1 to 5 in the fluid samples, and comparing the expression levels between different sampling times. | 2013-01-24 |
20130022986 | METHOD FOR MANUFACTURING PANCREATIC-HORMONE-PRODUCING CELLS - The present invention provides a method of more efficiently producing pancreas cells, particularly pancreatic hormone-producing cells, a method of stably producing pancreas cells in a large amount by more efficiently inducing differentiation of stem cells into pancreas cells, a medicament containing a pancreas cells and a screening method using the cells. | 2013-01-24 |
20130022987 | Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery - The invention relates to the discovery and use of novel antigens/autoantigens, polyclonal and monoclonal antibodies/autoantibodies thereto, and in particular methods of using the antigens/autoantigens and antibodies/autoantibodies in the diagnostic, prognostic, staging and therapeutic regimens for the control of colorectal cancer. | 2013-01-24 |
20130022988 | YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR - Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease. | 2013-01-24 |
20130022989 | DENTAL STEM CELL REPROGRAMMING - Provided is dental stem cell comprising an Oct3/4 transgene. Also provided is a method of making a pluripotent stem cell. Additionally, a method of preparing an insulin-secreting cell is provided. Further provided is an insulin-secreting cell prepared by that method. A method of preparing a chondrocyte-like cell is also provided, as is a chondrocyte-like cell prepared by that method. Additionally provided is a method of preparing a myocyte-like cell. Also, a myocyte-like cell prepared by that method is provided. A method of preparing a hair follicle-like cell is additionally provided, as is a hair follicle-like cell prepared by that method. A method of preparing a neuron-like cell is additionally provided, as is a neuron-like cell prepared by that method. | 2013-01-24 |
20130022990 | CELLULAR LABELING FOR NUCLEAR MAGNETIC RESONANCE TECHNIQUES - This disclosure provides, in part, fluorocarbon imaging reagents and formulations for the ex vivo labeling of cells. Labeled cells may be detected in vivo or ex vivo by a nuclear magnetic resonance technique, such as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The disclosure additionally provides methods for using the imaging reagents in a variety of clinical procedures. | 2013-01-24 |
20130022991 | CELL FREE CD4 QUANTITATION AND METHODS OF USE - The present invention provides a low-cost cell-free assay, the α-test, that provides point-of-care CD4 enumeration using a single platform assay thereby eliminating the need for high-end instrumentation, calibrated pipetting, and specialized technical training. The number of CD4 T cells in blood is driven by the concentration of the protein α1proteinase inhibitor (α1PI, α1antitrypsin, serpin A1). The invention features, in part, methods for determining the number of CD4+ T cells in a sample comprising determining the concentration of alpha 1 proteinase inhibitor (α1PI) in a sample; wherein the number of CD4+ T-cells is related to the concentration of α1PI. | 2013-01-24 |
20130022992 | IN VITRO ASSAY FOR QUANTIFYING CLOSTRIDIAL NEUROTOXIN ACTIVITY - Novel methods for determining the unknown biological activity of a clostridial neurotoxin in a sample with respect to the known biological activity of a clostridial neurotoxin in a reference sample, comprising the step of comparing the biological activity of a clostridial neurotoxin preparation with the biological activity of a standard preparation of a reference clostridial neurotoxin in certain in vitro systems. | 2013-01-24 |
20130022993 | COMPOUND, PHOSPHORYLATION INHIBITOR, INSULIN RESISTANCE IMPROVING AGENT, PREVENTIVE OR THERAPEUTIC AGENT FOR DIABETES, AND SCREENING METHOD - A new compound inhibiting phosphorylation of Ser727 of STAT3, a phosphorylation inhibitor containing the new compound, an insulin resistance improving agent and a preventive or therapeutic agent for diabetes; and a screening method for at least one of the insulin resistance improving agent and the preventive or therapeutic agent for diabetes. | 2013-01-24 |
20130022994 | REGULATION OF BACE DEGRADATION - The invention relates to methods and products for diagnosing, preventing, and treating Alzheimer's disease and abnormal production of amyloid β. | 2013-01-24 |
20130022995 | METAL NANOWIRE INCLUDING GOLD NANOCLUSTERS ON A SURFACE THEREOF FOR BINDING TARGET MATERIAL AND METHOD OF BINDING THE TARGET MATERIAL TO THE METAL NANOWIRE - A metal nanowire including gold nanoclusters on the surface thereof for binding a target material and a method of binding the target material to the metal nanowire are provided. | 2013-01-24 |
20130022996 | GENETICALLY MODIFIED MICE AND ENGRAFTMENT - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 2013-01-24 |
20130022997 | MONOCLONAL ANTIBODY AGAINST PBP2A DERIVED FROM MRSA WITH DUAL BINDING ACTIVITIES - Mouse monoclonal antibodies specifically recognizing the Penicillin Binding Protein 2a (PBP2a) derived from a strain of Methicillin-Resistant | 2013-01-24 |
20130022998 | GLYCODELIN MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER - Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention. | 2013-01-24 |
20130022999 | PROTEIN FRAGMENT COMPLEMENTATION ASSAYS FOR THE DETECTION OF BIOLOGICAL OR DRUG INTERACTIONS - The present invention describes a method for detecting biomolecular interactions said method comprising: (a) selecting an appropriate reporter molecule selected from the group consisting of a protein, a fluorescent protein, a luminescent protein and a phosphorescent protein; (b) effecting fragmentation of said reporter molecule such that said fragmentation results in reversible loss of reporter function; (c) fusing or attaching fragments of said reporter molecule separately to other molecules; followed by (d) reassociation of said reporter fragments through interactions of the molecules that are fused to said fragments; and (e) detecting said biomolecular interactions by reconstitution of activity of the reporter molecule | 2013-01-24 |
20130023000 | Devices and Formulations for Detecting, Screening and Monitoring Levels of Certain Constituents in Bodily Fluids and Method - A device is disclosed for conducting a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid. An indicator formulation of the device changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A carrier substrate of the device is constructed of a material having voids providing a high void volume within the substrate. The device is made by applying a chromagen to the carrier substrate to create a chromagen-laden carrier member. Then, a selected reagent having a particular constituent-specific formulation is applied to the chromagen-laden member. The selected reagent then combines with the chromagen, thereby establishing the indicator formulation within the carrier substrate in place for reception of a sample of the bodily fluid. | 2013-01-24 |
20130023001 | USE OF A SUBSTRATE IN A METHOD FOR MEASURING THE ACTIVITY OF PROTEOLYTIC ENZYMES - The disclosure relates to the use of a proteolytic enzyme substrate of general formula: Q | 2013-01-24 |
20130023002 | USE OF A SUBSTRATE IN A METHOD FOR MEASURING THE ACTIVITY OF AVAILABLE PROTEOLYTIC ENZYMES - The disclosure relates to the use of a proteolytic enzyme substrate of general formula: Q | 2013-01-24 |
20130023003 | KIT INCLUDING SUBSTRATES WITH VARIOUS SURFACE CHEMISTRIES - In one embodiment of the invention, there is provided a kit including: (i) a plasma polymerized surface having first and second regions, said first region including a first concentration of carboxylic acid groups on said plasma polymerized surface and said second region including a second concentration of carboxylic acid groups on said plasma polymerized surface, wherein said first concentration and said second concentration are different; (ii) a first plasma polymerized secondary substrate having carboxylic acid groups disposed consistently thereacross at a concentration equal to said first concentration; and, (iii) a second plasma polymerized secondary substrate having carboxylic acid groups disposed consistently thereacross at a concentration equal to said second concentration. | 2013-01-24 |
20130023004 | FLUOROGENIC SUBSTRATE FOR ADAMTS13 - Disclosed are fluorogenic substrates for measuring ADAMTS13 activity or ADAMTS13 inhibitor activity. Substrates can comprise an oligopeptide which can consist of up to 80 amino acids of sequence of von Willebrand Factor (VWF). The oligopeptide can include modifications of sequence of VWF, including an amino-terminal glycine, a scissile Y-M peptide, and a cysteine substitution located from 1 to 12 amino acids from the scissile Y-M in the carboxy terminal direction. A substrate can further comprise a fluorophore and a fluorescence quencher bound to the oligopeptide on opposite sides of the scissile Y-M peptide, wherein the fluorescence quencher is not identical to the fluorophore. An oligopeptide can be encoded by a nucleic acid sequence which can also encode a His tag. An oligopeptide can be expressed in a cell or microorganism. Also disclosed are methods of using a fluorogenic substrate to measure ADAMTS13 activity or ADAMTS13 inhibitor activity. | 2013-01-24 |
20130023005 | Coupling of Liquid Chromatography with Mass Spectrometry by Liquid Sample Desorption Electrospray Ionization (DESI) - An apparatus to separate and analyze components of a liquid sample include a high performance liquid chromatograph with a mass spectrometer utilizing desorption electrospray ionization. This permits separation and evaluation of different components in a liquid sample. Further, this can be combined with online derivation via reactive DESI and, further, can be used with further electrochemistry. | 2013-01-24 |
20130023006 | ANALYZER, METHOD FOR MEASURING A SAMPLE, AND NON-TRANSITORY MACHINE-READABLE STORAGE MEDIUM - An analyzer for measuring a sample includes a display, measurement hardware configured to perform a quality control measurement on a vial containing a quality control (QC) sample, and a controller. The controller is in communication with the display and the measurement hardware and is configured to communicate, via the display, instructions to implement a QC measurement on a first vial containing a first QC sample. If a result of the QC measurement is within a pre-determined range the first vial passes the QC measurement. If the result of the QC measurement is not within the pre-determined range the first vial fails the QC measurement. If the first vial fails the QC measurement and if a number of times the first vial fails the QC measurement is less than a predetermined number, the controller is configured to communicate, via the display, instructions to repeat the QC measurement on the first vial. | 2013-01-24 |
20130023007 | IDENTIFYING AND MEASURING RETICULOCYTES - Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value. | 2013-01-24 |
20130023008 | HISTOLOGICAL METHOD - The invention relates to the technical field of the histological preparation of biological tissue comprising a method and means for preparing transparent biological specimens for examination under a light microscope. | 2013-01-24 |
20130023009 | METHOD FOR SPECIFICALLY PRODUCING A JOINED DNA FRAGMENT COMPRISING A SEQUENCE DERIVED FROM A TARGET GENE - Provided is a method for selectively obtaining, for a given target gene, a “joined DNA fragment” wherein just a target gene fragment is joined with desired other DNA fragments, regardless of whether a DNA fragment containing a target gene sequence has been purified. In the provided method, a double-stranded joining DNA fragment containing a sequence A and/or a sequence B is selectively joined to the ends of a target gene fragment. A mixture of a double-stranded gene fragment, the 3′ end of which is protruding, and the double-stranded joining DNA fragment, which are related in a prescribed manner, undergoes at least two cycles of thermal denaturation, reassociation, and DNA synthesis, resulting in a “joined DNA fragment,” which is a double-stranded DNA fragment including at least one instance of a sequence resulting from joining sequence A, the target gene sequence, and sequence B. A “single-side joined DNA fragment” can also be obtained, by a similar method. | 2013-01-24 |
20130023010 | METHOD FOR REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION - A method for reverse transcription polymerase chain reaction comprises steps: preparing a capillary, and adding a reverse transcription enzyme into the capillary; and performing a lyophilization process on the RT enzyme contained by the capillary to fabricate the RT enzyme into a lyophilized RT reagent in the capillary. Therefore, a buffer solution, an RNA sample, a polymerase and a primer solution can be added into the capillary to re-dissolve the lyophilized RT reagent and enable a reverse transcription reaction and a polymerase chain reaction of the RNA sample to directly take place inside the capillary, so as to promote convenience and efficiency of experiment. | 2013-01-24 |
20130023011 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 2013-01-24 |
20130023012 | Recombinase-Based Methods for Producing Expression Vectors and Compositions for Use in Practicing the Same - Methods are provided for producing a vector that includes at least one spliceable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each include a site specific recombinase site, where the subject donor and acceptor vectors further include splice donor and acceptor sites that, upon site specific recombination of the donor and acceptor vectors, define an intron in the product vector of the recombination step. Also provided are compositions for use in practicing the subject methods, including the donor and acceptor vectors themselves, as well as systems and kits that include the same. The subject invention finds use in a variety of different applications, including the production of expression vectors that encode C-terminal tagged fusion proteins, the production of expression vectors that encode pure protein and not a fusion thereof, and the like. | 2013-01-24 |
20130023013 | METHOD FOR OBTAINING A FERMENTABLE PRODUCT FROM POLLUTED LIGNO-CELLULOSIC BIOMASS - A method for obtaining a fermentable product intended for the production of metabolites by fermentation, includes the following steps: a) detoxification of a polluted ligno-cellulosic raw material including at least one polluting component; solid-liquid extraction in order to extract the polluting component(s) from the ligno-cellulosic raw material by solubilisation using at least one solvent; recovery of the cleaned ligno-cellulosic raw material; b) pre-treatment of the cleaned ligno-cellulosic raw material by defibration; c) enzymatic hydrolysis of the pre-treated ligno-cellulosic raw material in the presence of cellulose, and obtaining a fermentable product; d) optional purification of the resulting fermentable product. The use of the resulting fermentable product for producing metabolites by fermentation, as well as to a specific method for producing ethanol from the fermentable product are also described. | 2013-01-24 |
20130023014 | NOVEL CELLULASE GENE - An object is to identify endoglucanase and β-glucosidase genes by isolating genomic DNA containing cellulase genes, which are classified into endoglucanases or β-glucosidases, from | 2013-01-24 |
20130023015 | Useful halophilic, thermostable and ionic liquids tolerant cellulases - The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a | 2013-01-24 |
20130023016 | L-ORNITHINE OR L-ARGININE PRODUCING STRAIN AND METHOD FOR PRODUCING L-ORNITHINE OR L-ARGININE - The present invention relates to a polynucleotide that is active to an acetyl glutamate synthase and acetyl ornithinase which are associated with ornithine or arginine biosynthesis from | 2013-01-24 |
20130023017 | METHOD FOR PRODUCING PYRIPYROPENE - There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene. A. The method of the present invention allows for the production of pyripyropene. | 2013-01-24 |
20130023018 | METHOD FOR PRODUCING ACYLOXYPYRANONE COMPOUND, METHOD FOR PRODUCING ALKYNE COMPOUND, AND METHOD FOR PRODUCING DIHYDROFURAN COMPOUND - An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R | 2013-01-24 |
20130023019 | Processing Biomass - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce an intermediate or product, e.g., by fermentation. | 2013-01-24 |
20130023020 | COOLING AND PROCESSING MATERIALS - Systems and methods for cooling and processing materials are disclosed. | 2013-01-24 |
20130023021 | ETHANOL PRODUCTIVITIES OF SACCHAROMYCES CEREVISIAE STRAINS IN FERMENTATION OF DILUTE-ACID HYDROLYZATES DEPEND ON THEIR FURAN REDUCTION CAPACITIES - The present invention relates to an ethanol producing microbial strain, such as | 2013-01-24 |
20130023022 | ETHANOL PRODUCTIVITIES OF SACCHAROMYCES CEREVISIAE STRAINS IN FERMENTATION OF DILUTE-ACID HYDROLYZATES DEPEND ON THEIR FURAN REDUCTION CAPACITIES - The present invention relates to an ethanol producing microbial strain, such as | 2013-01-24 |
20130023023 | ANTI-CANCER AGENT - Disclosed is a | 2013-01-24 |
20130023024 | CONJUGATE OF MAGNETIC PARTICLE AND SURFACE MODIFIER LINKED THROUGH CLEAVABLE PEPTIDE BOND - A conjugate is provided for cell processing, which comprises a magnetic particle and a surface modifier having specific affinity to a target cell. The particle and modifier are linked through a cleavable peptide bond. In a method of cell processing, the conjugate is attached to a target cell; the target cell attached to the conjugate is subject to magnetic processing; the peptide bond is cleaved to separate the processed target cell from the magnetic particle; the target cell separated from the magnetic particle is attached to a substrate. The magnetic particle may include an iron oxide, and the surface modifier may include a glucosamine. The particle and modifier may be linked by a linker comprising a protease recognition site and a peptide bond. The linker links the surface modifier to the particle, and cleavage of the peptide bond is catalyzed by a specific protease that recognizes the protease recognition site. | 2013-01-24 |
20130023025 | METHOD FOR SEPARATING CELLS, CELL CULTURE SUBSTRATE, AND DEVICE FOR SEPARATING CELLS - A method for separating cells which includes: adhering cells to the surface of a cell culture substrate containing a photo-acid generator that generates an acidic substance upon irradiation with active energy rays, and irradiating only a partial region of the cell culture substrate with the active energy rays to selectively remove the cells within the partial region, thereby separating the cells within the partial region and cells in other regions. | 2013-01-24 |
20130023026 | IMMOBILIZATION OF MEMBRANE PROTEINS ONTO SUPPORTS VIA AN AMPHIPHILE - The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond. | 2013-01-24 |
20130023027 | FUSION PROTEINS OF BACTERIAL LUCIFERASE AS MULTICOLOR LUMINESCENT SENSORS - The present invention discloses systems and methods for altering the color of bacterial bioluminescence via a fusion protein complex by fusing | 2013-01-24 |
20130023028 | Variants Of A Polypeptide With Lipolytic Activity and Improved Stability - The invention relates to a method of preparing a variant of a parent polypeptide comprising: (a) providing an amino acid sequence of a parent polypeptide; (b) substituting at least one amino acid residue at a position in the sequence corresponding to any of positions: 41, 83, 129, 207 or 284 in SEQ ID No: 2; (c) selecting a variant with lipolytic activity, which compared to the parent polypeptide has improved stability, and has an amino acid sequence with at least 60% identity to the mature polypeptide of SEQ ID No: 2; and (d) recovering the variant. | 2013-01-24 |
20130023029 | NOVEL ASPARAGINASES AND USES THEREOF - The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes. | 2013-01-24 |
20130023030 | RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HYPIV2) FROM CDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS - Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome. | 2013-01-24 |
20130023031 | Pseudoinfectious Flavivirus and Uses Thereof - The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the | 2013-01-24 |
20130023032 | Synergistic Attenuation of Vesicular Stomatitis Virus, Vectors Thereof and Immunogenic Compositions Thereof - The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV), More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof. | 2013-01-24 |
20130023033 | PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM - The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in safety mechanism for ablating the therapeutic gene product, either permanently or temporarily, in response to a pharmacological agent—preferably an oral formulation, e.g., a pill. The invention is based, in part, on the applicants' development of an integrated approach, referred to herein as “PITA” (Pharmacologically Induced Transgene Ablation), for ablating a transgene or negatively regulating transgene expression. In this approach, replication-deficient viruses are used to deliver a transgene encoding a therapeutic product (an RNA or a protein) so that it is expressed in the subject, but can be reversibly or irreversibly turned off by administering the pharmacological agent; e.g., by administration of a small molecule that induces expression of an ablator specific for the transgene or its RNA transcript. | 2013-01-24 |
20130023034 | MUTATED REP ENCODING SEQUENCES FOR USE IN AAV PRODUCTION - The invention relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein a nuclear localization signal (NLS) in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. The invention also relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein the zinc finger domain in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. Further, the invention relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein an amino acid at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 of the said Parvoviral Rep protein is mutated in comparison to a corresponding wild type sequence, said amino acid position being defined with reference to SEQ ID NO: 2. | 2013-01-24 |
20130023035 | REGULATION OF TOXIN AND ANTITOXIN GENES FOR BIOLOGICAL CONTAINMENT - The present invention relates to the regulation of a toxin and/or antitoxin genes in a genetically engineered microorganism, such as cyanobacterial or eukaryotic algal strains, in particular for preventing unintentional and/or uncontrolled spread of the microorganisms. The present invention also includes methods of controlling the growth and/or survival of the engineered microorganism | 2013-01-24 |
20130023036 | NUCLEIC ACID CONSTRUCT, RECOMBINANT VECTOR, AND RECOMBINANT E. COLI PRODUCING CHICKEN ANEMIA VIRUS VP1 PROTEIN - Disclosed herein is an expression cassette adapted to be expressed in an | 2013-01-24 |
20130023037 | Compost organic-matter accelerated bioremediation - The process for bioremediation of contaminated sludge including the steps of mixing the contaminated sludge with immature compost in the thermophilic phase; nutrients; inoculants; enzymes and microbes. The mixed composition is composted indoors by microbial breakdown, by controlling temperature; moisture; aeration, porosity and pH. The mixed composition is matured by fungal breakdown, by setting the mixed composition outdoors in windrows. The mixed composition is then stabilized by spreading it on a soil surface in a layer of less than one meter thick. | 2013-01-24 |
20130023038 | Apparatus and Methods For Processing Biological Samples and a Reservoir Therefor - An apparatus for processing at least one biological sample accommodated on at least one carrier member ( | 2013-01-24 |
20130023039 | HIGH MULTIPLEX ARRAYS AND SYSTEMS - Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination. | 2013-01-24 |
20130023040 | METHODS AND APPARATUS FOR SELECTIVELY PROCESSING EGGS HAVING IDENTIFIED CHARACTERISTICS - Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to identify eggs having the characteristic, and then eggs identified as having the characteristic are processed accordingly. | 2013-01-24 |
20130023041 | Method and Apparatus for Holding Cells - The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells. | 2013-01-24 |
20130023042 | METAL BUFFER LAYER ASSISTED GUIDED MODE RESONANCE BIOSENSOR - A metal buffer layer assisted guided mode resonance (GMR) biosensor is disclosed. The GMR biosensor includes a substrate, a metal buffer layer and a waveguide layer. The metal buffer layer is disposed on the substrate and the waveguide layer is disposed on the metal buffer layer. The metal buffer layer, which is disposed adjacent to the waveguide layer, can carry out the total reflection and provide extra phase compensation of the total reflection at the same time. Accordingly, the propagation constant of the resonance wave would be much closer to the sensitivity of the phase, and the resonance electric field of the GMR biosensor would be much closer to the sensitive area. Consequently, the sensitivity of the GMR biosensor could be improved. | 2013-01-24 |
20130023043 | GRAVITY FLOW TUBULAR PHOTOBIOREACTOR AND PHOTOBIOREACTOR FARM - A gravity flow photobioreactor core ( | 2013-01-24 |
20130023044 | System and Method for Fuel Generation from Algae - A novel algae bioreactor and biofuel production system is presented that uses an efficient distribution and delivery mechanism for light, water, nutrient, and carbon dioxide. An efficient light delivery system uses multiple LEDs at red and blue wavelengths to enhance/optimize the algal growth. In addition, multiple light rods are immerses in large and deep bioreactor to achieve even growth of algae within the tank. A novel water/nutrient/CO | 2013-01-24 |
20130023045 | INDUCED HEPATIC STEM CELL AND PROCESS FOR PRODUCTION THEREOF, AND APPLICATIONS OF THE CELL - The present invention relates to an induced hepatic stem cell defined as follows, a process for production thereof, and applications of the cell, which are useful in safety tests, toxicity tests, metabolism tests, drug interaction tests, antiviral activity tests, screening tests for pharmaceuticals such as hyperlipidemic therapeutics, hypertension therapeutics, low-molecular weight compound medicaments, and antibody medicaments, screening for targets in drug discovery, preparation of animal models, production of hepatocyte-produced proteins, and in regenerative medicine. The induced hepatic stem cell of the present invention is characterized by at least satisfying the following requirements (1)-(3): (1) it expresses at least 15 genes as selected from the group of the genes which are marker genes for an embryonic stem cell; (2) it has properties of a hepatocyte; and (3) it can be subjected to expansion culture or passage culture for at least 3 days. | 2013-01-24 |
20130023046 | MULTIPOTENT ADULT STEM CELL POPULATION - The present invention relates to the discovery of a population of non-germ adult stem cells that can be found in tissue from non-embryonic mammals, including at least mouse, rat, pig and human. These adult stem cells, which are present within the post-natal individual at all ages from infancy to senescence have a phenotype and developmental potential that is different from stem cell types, embryonic and adult, that have so far been described. | 2013-01-24 |
20130023047 | Nucleic Acids Encoding Humanized Anti-CD40 Antibodies - Provided are humanized anti-CD40 antibodies and antigen-binding fragments and methods for treating disease characterized by expression of CD40 antigen. | 2013-01-24 |
20130023048 | Method of Inducing High Activity of Human Adipose Stem Cell and Medium Therefor - The present invention relates to a method of inducing high activity of human adipose stem cells, highly active stem cells induced by the method, cell therapeutic agents including the highly active stem cells, and a medium for inducing high activity of human adipose stem cells. | 2013-01-24 |
20130023049 | VIABLE CELLS FROM FROZEN UMBILICAL CORD TISSUE - Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs. | 2013-01-24 |
20130023050 | METHOD FOR CULTURE OF CORNEAL ENDOTHELIAL CELLS, PROCESS FOR PRODUCTION OF CORNEAL ENDOTHELIAL CELL SHEET FOR TRANSPLANTATION PURPOSES, AND CULTURE KIT FOR CORNEAL ENDOTHELIAL CELLS - The invention provides a method of culturing a corneal endothelial cell by use of a culture medium containing an ascorbic acid derivative and the like. | 2013-01-24 |
20130023051 | TECHNIQUES FOR TRANSFECTING PROTOPLASTS - The invention relates to a method for the introduction of one or more molecules of interest in a plant cell protoplast by providing plant cell protoplasts, performing a first transfection of the plant cell protoplast with a composition that is capable of altering the regulation of one or more pathways selected from the group consisting of Mismatch Repair System and Non-Homologous End Joining and/or a composition that is capable of introducing DSBs, performing a second transfection of the plant cell protoplast with one or more molecules of interest such as mutagenic oligonucleotides and allowing the cell wall to form. | 2013-01-24 |
20130023052 | MANIPULATOR SYSTEM AND MANIPULATION METHOD OF MICROMANIPULATION TARGET OBJECT - A manipulator system and a manipulation method of a micromanipulation target object, which are capable of automatically executing a variety of operations about a micromanipulation target object such as an ovum that have hitherto required a skilled technique, are disclosed. A manipulator system includes: a microscope unit observing a micromanipulation target object; a pair of manipulators being electrically drivable in X-, Y- and Z-axis three directions for manipulating the micromanipulation target object; a sample stage receiving a placement of the micromanipulation target object and being electrically drivable in X-Y axis plane directions; a control unit controlling the drive of the manipulators and the drive of the sample stage; and a manipulation unit driving the manipulators and the sample stage via the control unit, wherein a manipulation tool is fitted to the manipulator, the control unit gets stored with positional information of the manipulation tool with respect to a plurality of regions set for the micromanipulation target object, and at least one of relative movements between the regions of the manipulation tool by the sample stage and/or the manipulator is automatically conducted based on the stored positional information. | 2013-01-24 |
20130023053 | METHODS AND COMPOSITIONS FOR TARGETED MUTAGENESIS IN BACTERIA - This disclosure provides methods and compositions for targeted mutagenesis of specific genes in a bacterial strain. By inducibly over-expressing error-prone polymerases such as Pol IV or Pol V in conjunction with nickase in a bacterial strain, and housing the targeted gene(s) on an episome or plasmid which contains one or more nickase recognition sequences, the targeted gene(s) can be selectively mutated at rates significantly greater than genes contained on the chromosome. The methods disclosed herein are useful for engineering desirable bacterial phenotypes and novel strains, including for example strains useful for treating or degrading waste and/or environmental contaminants, for optimizing bioprocesses, and for converting low-value feed-stock into value-added products. | 2013-01-24 |
20130023054 | LIPID BIOMARKERS FOR STABLE AND UNSTABLE HEART DISEASE - The present invention relates generally to the field of diagnostic and prognostic assays for heart disease. More particular, the present invention provides an assay for diagnosing the presence or extent of development of heart disease or its classification or state thereof. The assay of the present invention is also useful in the stratification of a subject with respect to a risk of developing heart disease. The assay of the present invention is also capable of integration into pathology architecture to provide a diagnostic and reporting system. | 2013-01-24 |
20130023055 | METHODS FOR MEASUREMENT OF CALCIUM IONS - Reagents and methods for determination of calcium within a sample. Specific embodiments include a reagent for determination of calcium comprising a mono-nitro substituted BAPTA-type chelator (BAPTA=1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid). Methods for accurate determination of calcium in a sample, such as a blood, whole blood, plasma or serum or any other aqueous liquid sample including cerebrospinal fluid, lymph, salivary juice or urine. Embodiments are also useful for clinical diagnoses. | 2013-01-24 |
20130023056 | EARLY DETECTION OF RECURRENT BREAST CANCER USING METABOLITE PROFILING - A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GC×GC-MS) to produce the metabolite profiles of serum samples. The NMR and GC×GC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease. | 2013-01-24 |
20130023057 | BIDIRECTIONAL BALLAST - An analyzer with a combustion furnace includes a flow path of byproducts of combustion coupled to a bidirectional ballast chamber by valves which are sequentially actuated for alternately filling and exhausting byproducts of combustion from opposite sides of the chamber during combustion. Alternately, a plurality of low volume ballast chambers are employed. A method of determining the concentration of elements in a sample includes the steps of combusting a sample; and alternately collecting and exhausting the byproduct gases of combustion in opposite sides of a bidirectional ballast. The bidirectional ballast chamber has an outer wall defining a chamber with sealed enclosures at opposite ends of the wall, a movable piston positioned within the chamber, and gas ports associated with the chamber on opposite sides of the piston. | 2013-01-24 |
20130023058 | METHOD AND APPARATUS FOR SELECTING A PRODUCT - A method of selecting a product suited to an individual. The method includes: identifying a product category from a predefined set of product categories, each product category being associated with a set of products; on the basis of said selected product category, selecting a genetic testing cartridge type from a set of available cartridge types, each cartridge type being configured to perform a genotype profiling test on a polynucleotide sample; collecting a polynucleotide sample from the individual; performing a genotype profiling test on said polynucleotide sample using a genetic testing cartridge of the selected genetic testing cartridge type; and using the result of said test to select a product from within the identified product category. | 2013-01-24 |
20130023059 | METHOD FOR IMMOBILIZING STREPTAVIDIN ON A SELF-ASSEMBLED MONOLAYER - Provided are a method for increasing an amount of streptavidin to be immobilized on the self-assembled monolayer and a sensor which comprises streptavidin immobilized with the method. The method of the current technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of streptavidin. | 2013-01-24 |
20130023060 | MICROFLUIDIC ELEMENT WITH MULTI-FUNCTIONAL MEASURING CHAMBER FOR THE ANALYSIS OF A FLUID SAMPLE - A test element, analytical system and method for optical analysis of fluid samples is provided. The test element has a substrate and a microfluidic channel structure, which is enclosed by the substrate and a cover layer. The channel structure has a measuring chamber with an inlet opening. The test element has a first level, which faces the cover layer, and a second level, which interconnects with the first level such that the first level is positioned between the cover layer and the second level. A part of the measuring chamber extending through the first level forms a measuring zone connecting with a part of the measuring chamber that extends partially into the second level, forming a mixing zone. Optical analysis of fluid samples is carried out by light guided through the first level parallel to the cover layer, such that the light traverses the measuring zone along an optical axis. | 2013-01-24 |
20130023061 | METHOD FOR STABILIZING GLYCEROPHOSPHOLIPIDS AND REAGENTS USING SAME - Disclosed is an accurate and stable immunoassay reagent using a glycerophospholipid and a method for stabilizing the reagent. The reagent for assaying an analyte in blood by immune reaction with an antigen when the analyte is an antibody or with an antibody when the analyte is an antigen, wherein a glycerophospholipid and a polyvinylpyrrolidone are incorporated into the immune reaction system. | 2013-01-24 |
20130023062 | THIN FILM MANUFACTURING APPARATUS, THIN FILM MANUFACTURING METHOD AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - In an apparatus for manufacturing a ceramic thin film by employing a thermal CVD method, an internal jig, which is provided with a heat radiation material film on the surface, is provided at a position that faces a substrate (S) on which the film is to be formed. The thin film and a semiconductor device are manufactured using such apparatus. | 2013-01-24 |
20130023063 | METHOD FOR MANUFACTURING FERROELECTRIC DEVICE - A seed layer having a predetermined pattern is formed on a side of one surface of a second substrate, and a ferroelectric layer is formed on the side of the one surface of the second substrate. A lower electrode is formed on the ferroelectric layer, and the lower electrode and a first substrate are bonded via a bonding layer. A laser beam with a predetermined wavelength is irradiated from a side of other surface of the second substrate to transfer a ferroelectric film, which overlaps with the seed layer, of the ferroelectric layer and the seed layer onto the side of said one surface of the first substrate. The laser beam passes through the second substrate, is reflected by the seed layer, and is absorbed by a second portion of the ferroelectric layer. The second portion does not overlap with the seed layer. | 2013-01-24 |
20130023064 | Negative Ion Control for Dielectric Etch - Apparatus, methods, and computer programs for semiconductor processing in a capacitively-coupled plasma chamber are provided. A chamber includes a bottom radio frequency (RF) signal generator, a top RF signal generator, and an RF phase controller. The bottom RF signal generator is coupled to the bottom electrode in the chamber, and the top RF signal generator is coupled to the top electrode. Further, the bottom RF signal is set at a first phase, and the top RF signal is set at a second phase. The RF phase controller is operable to receive the bottom RF signal and operable to set the value of the second phase. Additionally, the RF phase controller is operable to track the first phase and the second phase to maintain a time difference between the maximum of the top RF signal and the minimum of the bottom RF signal at approximately a predetermined constant value, resulting in an increase of the negative ion flux to the surface of the wafer. | 2013-01-24 |
20130023065 | Apparatus and Methods for End Point Determination in Reactive Ion Etching - Methods and apparatus for performing end point determination. A method includes receiving a wafer into an etch tool chamber for performing an RIE etch; beginning the RIE etch to form vias in the wafer; receiving in-situ measurements of one or more physical parameters of the etch tool chamber that are correlated to the RIE etch process; providing a virtual metrology model for the RIE etch in the chamber; inputting the received in-situ measurements to the virtual metrology model for the RIE etch in the chamber; executing the virtual metrology model to estimate the current via depth; comparing the estimated current via depth to a target depth; and when the comparing indicates the current via depth is within a predetermined threshold of the target depth; outputting a stop signal. An apparatus for use with the method embodiment is disclosed. | 2013-01-24 |
20130023066 | SYSTEM AND METHOD FOR INCREASING PRODUCTIVITY OF ORGANIC LIGHT EMITTING DIODE MATERIAL SCREENING - A system and method of increasing productivity of OLED material screening includes providing a substrate that includes an organic semiconductor, processing regions on the substrate by combinatorially varying parameters associated with the OLED device production on the substrate, performing a first characterization test on the processed regions on the substrate to generate first results, processing regions on the substrate in a combinatorial manner by varying parameters associated with the OLED device production on the substrate based on the first results of the first characterization test, performing a second characterization test on the processed regions on the substrate to generate second results, and determining whether the substrate meets a predetermined quality threshold based on the second results. | 2013-01-24 |
20130023067 | Methods for Improving Integrated Photonic Device Uniformity - A method is described for improving the uniformity over a predetermined substrate area of a spectral response of photonic devices fabricated in a thin device layer. The method includes (i) establishing an initial device layer thickness map for the predetermined area, (ii) establishing a linewidth map for the predetermined area, and (iii) establishing an etch depth map for the predetermined area. The method further includes, based on the initial device layer thickness map, the linewidth map and the etch depth map, calculating an optimal device layer thickness map and a corresponding thickness correction map for the predetermined substrate area taking into account photonic device design data. Still further, the method includes performing a location specific corrective etch process in accordance with the thickness correction map. | 2013-01-24 |
20130023068 | MANUFACTURE OF PHOTOVOLTAIC MODULE COMPRISING CELL ASSEMBLY - The present invention relates to the manufacture of a photovoltaic cell panel, said manufacture comprising the steps of: a) obtaining photovoltaic (PV) films that are each intended for a cell and are placed onto a front surface of a metal substrate; b) applying at least one conductive film (CG, CND) onto each front surface of a photovoltaic film; c) cutting up the substrate (SUB) so as to isolate the cells from each other; and d) encapsulating (ENC) the cells on a common mounting. According to the invention, steps d) and c) are reversed, so step d) relates to encapsulating the front surface of the substrate before step c), cutting the substrate up by the rear surface thereof. Additionally,—in step b), an area of the conductive film is extended over the substrate so that the conductive film simultaneously makes contact with the front surface of the photovoltaic film and the front surface of the substrate, and—in step c), the substrate is cut up so as to avoid short-circuiting between the photovoltaic cells, at least under the above-mentioned area of the conductive film and over a substrate width less than the width of the area. | 2013-01-24 |
20130023069 | METHOD FOR CHECKING ION IMPLANTATION CONDITION AND METHOD FOR MANUFACTURING SEMICONDUCTOR WAFER - A method for checking an ion implantation condition when ions are implanted over an entirety of one surface of a semiconductor wafer having an insulator film on the one surface, the method including checking whether the ions are implanted over the entirety of the one surface of the semiconductor wafer by directly or indirectly observing light emitted when the one surface of the semiconductor wafer is irradiated with an ion beam of the implanted ions throughout the ion implantation. | 2013-01-24 |