04th week of 2020 patent applcation highlights part 24 |
Patent application number | Title | Published |
20200024604 | EXOSOMES AND MICRO-RIBONUCLEIC ACIDS FOR TISSUE REGENERATION - Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in tum result in improved cell or tissue viability and/or function. | 2020-01-23 |
20200024605 | OLIGOMERS AND OLIGOMER CONJUGATES - The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer. | 2020-01-23 |
20200024606 | ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASES - Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency. | 2020-01-23 |
20200024607 | COMPOSITIONS AND METHODS OF BIOSYNTHESIZING CAROTENOIDS AND THEIR DERIVATIVES - The present invention relates to compositions and methods of producing carotenoids and carotenoid derivatives. | 2020-01-23 |
20200024608 | A PLATFORM OF COMPOSABLE MAMMALIAN ELEMENTS OF TRANSCRIPTION (COMET) - Disclosed are systems and methods that include or utilize composable mammalian elements of transcription (COMET) including engineered recombinant proteins that regulate transcription and engineered DNA promoter sequences that are regulated by the engineered recombinant proteins. The elements may be composed to form logic gates, gene expression cascades and programs, and cell-based biosensors. | 2020-01-23 |
20200024609 | MATING TYPE SWITCH IN YARROWIA LIPOLYTICA - The present invention is directed to a process for switching the mating type of a | 2020-01-23 |
20200024610 | METHOD FOR SELECTING TARGET SITES FOR SITE-SPECIFIC GENOME MODIFICATION IN PLANTS - The present disclosure provides methods and compositions for identification of optimal genomic loci in plant genome for site-directed integration in plants. | 2020-01-23 |
20200024611 | GENE TARGETING IN PLANTS USING A CHIMERIC MULTI DOMAIN RECOMBINATION PROTEIN - An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least two flanking sequences capable of binding to a donor binding domain of the protein, the sequences being located adjacent to each end of the donor polynucleotide sequence forming left and right borders thereto. | 2020-01-23 |
20200024612 | WHEAT WITH REDUCED LIPOXYGENASE ACTIVITY - A series of independent human-induced non-transgenic mutations found at one or more of the Lpx genes of wheat; wheat plants having these mutations in one or more of their Lpx genes; and a method of creating and finding similar and/or additional mutations of Lpx by screening pooled and/or individual wheat plants. The wheat plants disclosed herein exhibit decreased lipoxygenase activity without having the inclusion of foreign nucleic acids in their genomes. Additionally, products produced from the wheat plants disclosed herein display increased oxidative stability and increased shelf life without having the inclusion of foreign nucleic acids in their genomes. | 2020-01-23 |
20200024613 | NOVEL PLANT-DERIVED CIS-REGULATORY ELEMENTS FOR THE DEVELOPMENT OF PATHOGEN-RESPONSIVE CHIMERIC PROMOTORS - The invention relates to an isolated cis-regulatory element imparting pathogen inducibility or elicitor inducibility, which comprises a nucleic acid molecule, the molecule sequence of which corresponds to one of the core sequence motifs comprising a) vaaagtm, b) aaacca, c) scaaam, d) acrcg, e) sktgkact, f) mrtsack, g) ccaccaa, h) tcgtctcttc (SEQ ID NO: 35), i) wwkgwc or a core sequence motif complementary to a) to i). | 2020-01-23 |
20200024614 | NOVEL INSECTICIDAL PROTEINS FROM PLANTS - Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. | 2020-01-23 |
20200024615 | Method for Precise Identification, Targeting and Delivery of Directed Therapies for Destruction of Cancerous Cells - This invention teaches systems and methods for identifying, targeting and destroying cancer cells with a cell-killing vector attracted to signature elements common to most cancer cells. As cells progress from a normal to a cancerous state their accelerated metabolic rates and adapted pathways generate excess amounts of H | 2020-01-23 |
20200024616 | NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS WITH ENHANCED HUMAN PANCREATIC TROPISM - The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human pancreatic tissue or human islets as compared non-variant parent capsid polypeptides. | 2020-01-23 |
20200024617 | RECOMBINANT AAV VARIANTS AND USES THEREOF - The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same. | 2020-01-23 |
20200024618 | RNA-Guided Transcriptional Regulation - Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid. | 2020-01-23 |
20200024619 | IMPROVED GLYCEROL FREE ETHANOL PRODUCTION - The invention relates to a recombinant cell, preferably a yeast cell comprising one or more genes coding for an enzyme having glycerol dehydrogenase activity, one or more genes coding dihydroxyacetone kinase (E.C. 2.7.1.28 and/or E.C. 2.7.1.29); one or more genes coding for an enzyme in an acetyl-CoA-production pathway and one or more genes coding for an enzyme having at least NAD | 2020-01-23 |
20200024620 | PROCESSES FOR PRODUCING FERMENTATION PRODUCTS - The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and optionally a thermostable protease, pullulanase and/or glucoamylase are present and/or added during liquefaction, wherein a cellulolytic composition is present and/or added during fermentation or simultaneous saccharification and fermentation. The invention also relates to a composition suitable for use in a process of the invention. | 2020-01-23 |
20200024621 | ENZYMATIC PROCESS FOR THE PREPARATION OF (1S,2R)-2-(DIFLUOROMETHYL)-1-(PROPOXYCARBONYL)CYCLOPROPANECARBOXYLIC ACID - Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors. | 2020-01-23 |
20200024622 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids. | 2020-01-23 |
20200024623 | MICROORGANISMS HAVING INCREASED LIPID PRODUCTION, AND COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides a mutant algal microorganism that has a mutation that causes attenuated expression of TrifuncB and/or TrifuncA and as a result produces more lipids than a control algal microorganism. The mutant algal microorganism can further include a mutation in a gene encoding a peroxisomal beta-oxidation pathway protein, such as an ACO1 or PXA1 gene, or a glyoxylate pathway protein, such as an ICL1 gene, that results in attenuated expression and further increased lipid production. Furthermore, provided herein are methods of producing lipids using the mutant algal microorganisms and methods of making the mutant microorganisms. | 2020-01-23 |
20200024624 | PROCESS OF OMEGA-HYDROXYL FATTY ACID PRODUCTION - Provided is a method of producing at least one omega-hydroxyl fatty acid, the method comprising: (a) contacting at least one alkane with at least one recombinant yeast cell in an aqueous medium, wherein the yeast cell is capable of oxidising the alkane to the corresponding omega-hydroxyl fatty acid and the yeast cell comprises a reduced fatty acid degradation capacity. | 2020-01-23 |
20200024625 | Corynebacterium Constitutive Expression Vector Promoter Screened On The Basis Of Transcriptome Sequencing, Screening Method Thereof, And Applications Thereof - Provided is a method for screening a | 2020-01-23 |
20200024626 | MICROORGANISM PRODUCING O-ACETYL HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL HOMOSERINE USING THE SAME - Disclosed is a microorganism of | 2020-01-23 |
20200024627 | COMPOSITION FOR PRODUCING TAGATOSE AND METHOD OF PRODUCING TAGATOSE USING THE SAME - Provided are a composition for producing tagatose, comprising fructose-4-epimerase, and a method of producing tagatose using the same. | 2020-01-23 |
20200024628 | MUTANT ENDOGLYCOCERAMIDASES WITH ENHANCED SYNTHETIC ACTIVITY - The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme. | 2020-01-23 |
20200024629 | Method for Producing RNA - A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells. | 2020-01-23 |
20200024630 | Production of Steviol Glycosides in Recombiant Hosts - The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors. | 2020-01-23 |
20200024631 | REDOX ENZYME-EMBEDDED PYRENE-POLY(ETHYLENIMINE) HYDROGEL ELECTRODE FOR ELECTROSYNTHESIS - Devices, systems, and compositions of matter involving enzyme-mediated bioelectrocatalysis are disclosed and described. An enzyme electrode can include an electrode, a bioelectric material coupled to the electrode, the bioelectric material further including a water-permeable polymer matrix, a planar linker covalently coupled to the water-permeable polymer matrix and noncovalently coupled to the electrode, and electrochemically active oxidoreductase enzyme molecules functionally embedded in the water-permeable polymer matrix. | 2020-01-23 |
20200024632 | METHOD OF MAKING AN ELECTROCHEMICAL SENSOR STRIP - A method of making an electrochemical sensor strip that includes: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode; and applying a second layer onto the second electrode. The first layer includes an oxidoreductase and a mediator. The second layer includes a soluble redox species. | 2020-01-23 |
20200024633 | ANTIMICROBIAL SUSCEPTIBILITY TESTING AND MICROBIAL IDENTIFICATION - Systems and methods for microbe identification (ID) in the context of phenotypic antimicrobial susceptibility testing (AST). Approaches for rapidly identifying polymicrobial samples are introduced that following perform one or more ID methods, such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), PCR, or DNA hybridization, following sample incubation in two or more different media, including at least one selective media. Parallel ID and AST workflows are provided that may reduce the time from sample to AST result. | 2020-01-23 |
20200024634 | METHODS AND SYSTEMS OF CHARACTERIZING AND COUNTING MICROBIOLOGICAL COLONIES - Described herein are methods, systems, and non-transitory computer-readable media to non-destructively acquire three-dimensional profiles of cellular microbiological samples growing on the surface of a solid growth medium. Acquisitions can be performed by an optical microscope that includes a vertical scanning interferometer. The three-dimensional profiles can enable measurement of sample parameters of microcolonies, which can be made of microbial colony forming units. The methods and systems enable early and rapid detection and quantification of microbes. | 2020-01-23 |
20200024635 | METHOD OF DETECTION - The present invention is directed to a method for detecting the presence or absence of a bacterium resistant to a cyclic cationic polypeptide antibiotic, comprising: (a) subjecting a test sample to mass spectrometry analysis and generating a mass spectrum output; wherein said test sample comprises a bacterial membrane or a fragment thereof, wherein the fragment comprises a non-Lipid A component; (b) identifying in said mass spectrum output a first defined peak indicative of the presence of Lipid A modified by phosphoethanolamine, wherein said first defined peak is a peak present in a mass spectrum output for Lipid A modified by phospho-ethanolamine and wherein said first defined peak is absent from a corresponding mass spectrum output for native Lipid A; and (c) wherein the presence of said first defined peak indicates the presence of a bacterium resistant to a cyclic cationic polypeptide antibiotic, and wherein the absence of said first defined peak indicates the absence of a bacterium resistant to a cyclic cationic polypeptide antibiotic. This method is also used in a screening method to identify an inhibitor of cyclic cationic polypeptide antibiotic resistance in a bacterium. The matrix solution can contain 2,5-dihydroxybenzoic acid and aids in the selective extraction, co-crystallisation and ionisation of native Lipid A and/or modified Lipid A as an integral part of a bacterial membrane. | 2020-01-23 |
20200024636 | PREDICTED METABOLITES FOR BIOINDICATORS AND/OR IDENTIFICATION OF MICROBES WITH SPECIFIC METABOLITES - A method including: obtaining a field sample; extracting DNA from the field sample and identifying a marker gene; amplifying and sequencing the marker gene; identifying a genetic makeup of the marker gene; identifying a potential compound associated with the genetic makeup; and identifying a gene associated with the potential compound and associating that gene with a metabolite. | 2020-01-23 |
20200024637 | BIOLUMINESCENT ASSAYS UTILISING SECRETED LUCIFERASES - Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase. | 2020-01-23 |
20200024638 | BIOLOGICAL SAMPLE AND BIOLOGICAL INSTRUMENT CLEANLINESS MEASUREMENT KIT AND METHOD - Provided are a kit and a method for measuring cleanliness of a bio-related sample and a bio-related instrument, which is not susceptible to ATP-degrading activity. Provided are a method for measuring cleanliness of a bio-related sample or a bio-related instrument and a kit therefor, comprising using an enzyme that catalyzes a reaction that produces ATP from ADP, luciferin, luciferase, and a metal salt. Also provided are a method further comprising using pyruvate orthophosphate dikinase (PPDK), adenylate kinase (ADK), or pyruvate-water dikinase (PWDK) and a kit further comprising PPDK, ADK, or PWDK. Further provided are a method for measuring cleanliness of a bio-related sample or a bio-related instrument and a kit therefor, comprising using an enzyme that catalyzes a reaction that produces ATP from AMP, an enzyme that catalyzes a reaction that produces AMP from ADP, luciferin, luciferase, and a metal salt. | 2020-01-23 |
20200024639 | STABLE VAMP REPORTER ASSAY - The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same. | 2020-01-23 |
20200024640 | METHODS OF ANALYSIS OF METHYLATION - Methods for determining the methylation status of a plurality of cytosines are disclosed. In some aspects genomic DNA target sequences containing CpGs are targeted for analysis by multiplex amplification using target specific probes that can be specifically degraded prior to amplification. The targets may be modified with bisulfite prior to amplification. In another aspect targets are cut with methylation sensitive or insensitive restriction enzymes and marked with a tag using the target specific probes. The presence or absence of methylation may be determined using methylation sensitive restriction enzyme or bisulfite treatment. Detection in many embodiments employs hybridization to tag arrays, genotyping arrays or resequencing arrays. | 2020-01-23 |
20200024641 | HIGHLY-MULTIPLEXED FLUORESCENT IMAGING - Provided herein is a method and system for analyzing a sample. In some embodiments the method makes use of a plurality of capture agents that are each linked to a different oligonucleotide and a corresponding plurality of labeled nucleic acid probes, wherein each of the labeled nucleic acid probes specifically hybridizes with only one of the oligonucleotides. The sample is labeled with the capture agents en masse, and sub-sets of the capture agents are detected using iterative cycles using corresponding subsets of the labeled nucleic acid probes. | 2020-01-23 |
20200024642 | METHODS AND KITS FOR IMPROVING GLOBAL GENE EXPRESSION ANALYSIS OF HUMAN URINE DERIVED RNA - Disclosed are methods and kits for improving global gene expression analysis for a population of RNA molecules derived from a human urine sample. In an embodiment, the method comprises the step of selectively depleting miR-10a-5p fragments from the population of RNA molecules or selectively blocking miR-10a-5p fragments within the RNA population. The miR-10a-5p depleted or miR-10a-5p blocked population of RNA can be used in a variety of global gene expression analysis protocols, including next generation sequencing. In a further embodiment, the method comprises selectively depleting or blocking miR-10b-5p fragments within the RNA population. The miR-10a-5p and/or miR-10b-5p depleted or blocked populations of RNA can also be used in global gene expression analysis protocols, including next generation sequencing. The kit comprises oligonucleotide probes comprising a nucleotide sequence that is the complement to a nucleotide sequence of the miR-10a-5p and/or oligonucleotide probes comprising a nucleotide sequence that is the complement to a nucleotide sequence of miR-10b-5p. | 2020-01-23 |
20200024643 | METHODS FOR THE EPIGENETIC ANALYSIS OF DNA, PARTICULARLY CELL-FREE DNA - Methods are provided for the epigenetic analysis of cell-free DNA using organic boranes to convert oxidized 5-methylcytosine residues in the cell-free DNA to dihydrouracil (DHU) residues. Cell-free DNA is contacted with an organic borane selected to successively bring about reduction, deamination, and decarboxylation of oxidized 5-methylcytosine residues such as 5-carboxymethylcytosine and 5-formylcytosine, resulting in DHU residues in place thereof. Following amplification, the treated cell-free DNA is sequenced, with the DHU residues read as thymine residues. Reaction mixtures, kits and additional methods are also provided, as are related methods for the epigenetic analysis of DNA, including cell-free DNA. | 2020-01-23 |
20200024644 | SYSTEMS AND METHODS FOR COMBINED DETECTION OF GENETIC ALTERATIONS - Disclosed are systems and methods for simultaneous detection of DNA and RNA genetic alterations comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof, in a biofluid sample from the patient without physically separating RNA from DNA. The systems and methods are similarly applicable to the simultaneous detection of DNA and RNA genetic alterations in solid tissues comprising gene splicing variants, mutations, indel, copy number changes, fusion and combination thereof. The present method utilized a barcoding method for analysis. The streamlined methods improve the simplicity, quantification accuracy and detection sensitivity and specificity of non-invasive detections of biomarkers. | 2020-01-23 |
20200024645 | USE OF ANTICOAGULANTS IN THE POLYMERASE CHAIN REACTION - The invention provides a method and kit for preventing inhibition of a thermal cycling reaction by protein coagulation in a sample. | 2020-01-23 |
20200024646 | SYSTEM AND METHOD FOR TARGETED DEPLETION OF NUCLEIC ACIDS - The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex. | 2020-01-23 |
20200024647 | PCR DETECTION KIT FOR RAPIDLY IDENTIFYING SALMONELLA OF SPECIFIC SEROTYPES - The present disclosure relates to a PCR detection kit for rapidly identifying | 2020-01-23 |
20200024648 | ALLERGEN DETECTION - The present invention provides allergen detection molecules and devices useful in on-site and rapid detection of allergens, including food allergens. | 2020-01-23 |
20200024649 | Nanopipette Analysis of Polymers - The disclosure relates to devices and instruments for detecting and individually analyzing biomolecules, biomolecular complexes and biomolecules with ligands attached thereon. | 2020-01-23 |
20200024650 | Target Polynucleotide Detection and Sequencing by Incorporation of Modified Nucleotides for Nanaopore Analysis - Disclosed herein are methods and compositions for target polynucleotide identification by using modified nucleotides incorporated into the polynucleotide to facilitate detection via a nanopore device. | 2020-01-23 |
20200024651 | MODIFIED MULTIPLEX AND MULTISTEP AMPLIFICATION REACTIONS AND REAGENTS THEREFOR - The invention relates to reagents and methods for improving the efficiency of multiplex nucleic acid amplification, in particular where overlapping amplicons are to be generated. The invention also relates to reagents and methods for improving the efficiency of multistep nucleic acid amplification, in particular the performance of two separate amplification reactions designed to occur in sequence in the same reaction mixture or vessel. The invention further relates to reagents and methods for improving multistep nucleic acid amplification reactions by controlling the output of the first amplification reaction. In particular, primers are provided that minimise the formation of aberrant amplification products. Such primers are particularly useful where first and second amplification reactions take place in a single reaction mixture or vessel. | 2020-01-23 |
20200024652 | Method for Blocking miRNA - A method of reducing the abundance of a non-target micro-RNA (miRNA) that is part of a group of miRNAs is provided, including: (a) annealing a complementary region of a blocking nucleic acid to a binding site at a first end of the unwanted miRNA, ligating an adenylated nucleic acid adapter to the group of miRNAs, and performing RT-PCR on group of miRNAs. Kits and compounds for use with the method are also provided. | 2020-01-23 |
20200024653 | METHODS FOR CHARACTERIZING COPY NUMBER VARIATION USING PROXIMITY-LITIGATION SEQUENCING - Disclosed here is a method for detecting genome rearrangement in a biological sample, comprising: obtaining a contact matrix plotted from proximity ligation sequencing data of at least one chromosome; identifying an abnormal contact pattern in the contact matrix compared to the contact matrix of a reference genome; comparing the abnormal contact pattern in the contact matrix to one or more known patterns associated with genomic rearrangement to identify a type of genomic rearrangement causing the abnormal contact pattern. Also disclosed is a method for detecting genome rearrangement in a biological sample, comprising: selecting linked chromosomal fragments from proximity ligation sequencing data of at least one chromosome, identifying an abnormal covalent bonding pattern of the linked chromosomal fragments compared to a reference genome; and comparing the abnormal covalent bonding pattern to one or more known patterns associated with genomic rearrangement to identify genomic rearrangement causing the abnormal covalent | 2020-01-23 |
20200024654 | METHOD FOR NUCLEIC ACID DETECTION BY GUIDING THROUGH A NANOPORE - The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample. | 2020-01-23 |
20200024655 | HAIRPIN LOOP METHOD FOR DOUBLE STRAND POLYNUCLEOTIDE SEQUENCING USING TRANSMEMBRANE PORES - The invention relates to a new method of sequencing a double stranded target polynucleotide. The two strands of the double stranded target polynucleotide are linked by a bridging moiety. The two strands of the target polynucleotide are separated using a polynucleotide binding protein and the target polynucleotide is sequenced using a transmembrane pore. | 2020-01-23 |
20200024656 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR REPEAT SEQUENCING - A method for sequencing a nucleic acid template includes: (a) performing a first sequencing process including flowing nucleotides and/or reagents to the nucleic acid template according to a first predetermined ordering of nucleotides and/or reagents to obtain a first sequencing result; (b) after the first sequencing process, performing a second sequencing process including flowing nucleotides and/or reagents to the nucleic acid template according to a second predetermined ordering of nucleotides and/or reagents to obtain a second sequencing result, the second predetermined ordering of nucleotides and/or reagents being different from the first predetermined ordering of nucleotides and/or reagents and at least one of the first and second predetermined orderings of nucleotides and/or reagents being designed for repeat sequencing; and (c) determining a sequence of bases corresponding to at least a portion of the nucleic acid template using both the first sequencing result and the second sequencing result. | 2020-01-23 |
20200024657 | COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE SEQUENCING - Methods and compositions for characterizing a target polynucleotide, including, characterizing the sequence of the target polynucleotide, using the fractional translocation steps of the target polynucleotide's translocation through a pore. | 2020-01-23 |
20200024658 | METHOD AND APPARATUS FOR INTRA- AND INTER-PLATFORM INFORMATION TRANSFORMATION AND REUSE IN PREDICTIVE ANALYTICS AND PATTERN RECOGNITION - A method and a system for interpreting data between two quantitative genomic datasets are described, wherein datasets are associated with the same disease or condition, for example, samples from the same patient obtained on different genomic platforms with varying data acquisition parameters. The data samples in each of the first and second datasets are rank ordered and the relative distances among the data samples are determined. The value ranks and relative distances are then used to correlate to data samples in the first and second quantitative genomic datasets, with the output provided to a user, such as a clinician or a patient. | 2020-01-23 |
20200024659 | ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS - A method of sequencing a polynucleotide strand can include providing the polynucleotide strand with a primer annealed thereto and a polymerase operably bound to the polynucleotide strand; successively exposing the polynucleotide strand to the flow of four different dNTPs according to a first predetermined ordering; and successively exposing the polynucleotide strand to the flow of four different dNTPs according to a second predetermined ordering, wherein the second predetermined ordering is different from the first predetermined ordering. | 2020-01-23 |
20200024660 | ANIMAL MODEL OF NON-ALCOHOLIC LIVER DISEASE AND COMPOSITION OF DIAGNOSIS, PREVENTION OR TREATMENT FOR NON-ALCOHOLIC LIVER DISEASE - The present invention provides a method of manufacturing an animal model of non-alcoholic liver disease by using correlation among metabolic dysregulations through AKT regulation by Hippo signaling, and an animal model prepared by the method above, and a screening method of a therapeutic agent by using the animal model. | 2020-01-23 |
20200024661 | RESIN COMPOSITION AND FLOW CELLS INCORPORATING THE SAME - An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm. | 2020-01-23 |
20200024663 | METHOD FOR DETECTING MOOD DISORDERS - The object of the invention is to provide a method for easily and objectively detecting mood disorders in a subject by measuring the expression levels of prescribed genes in the peripheral blood of the subject, the reliability of the detection result being high. The invention also provides a method for detecting mood disorders in a subject, the method having a step for measuring the gene expression levels of ribosomal protein genes, CDKN1C, or any combination thereof in the peripheral blood derived from the subject, and detecting whether or not the subject has mood disorders on the basis of the measurement results. | 2020-01-23 |
20200024664 | USE OF HLA GENETIC STATUS TO ASSESS OR SELECT TREATMENT OF CELIAC DISEASE - Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (HLA) genotype, in particular HLA-DQ2.5 homozygosity, of a subject having or suspected of having Celiac disease. Also provided herein are methods of identifying (e.g., diagnosing) a subject, such as a subject having or suspected of having Celiac disease and/or assessing the efficacy of treatment of Celiac disease, e.g. by determining responsiveness to a therapeutic gluten peptide composition or cytokine response, and kits relating thereto. | 2020-01-23 |
20200024665 | TRPC6 INVOLVED IN GLOMERULONEPHRITIS - Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor Potential Cation Channel 6. The missense mutation is a P112Q substitution, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II, and alters the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest a novel mechanism for glomerular disease pathogenesis. | 2020-01-23 |
20200024666 | MAP2K1 (MEK1) AS A THERAPEUTIC TARGET FOR ARTERIOVENOUS MALFORMATIONS AND ASSOCIATED DISORDERS - Please insert the following Abstract on a separate sheet at the end of the application: The instant disclosure provides methods and compositions related to discovery of MAP2K (MEK1) as a therapeutic target for treatment or prevention of arteriovenous malformations (AVMs). Therapeutic and/or prophylactic uses and compositions of known MEK1 inhibitors, including small molecules and nucleic acid agents, are described. | 2020-01-23 |
20200024667 | MIRNA BASED TREATMENT MONITORING IN MULTIPLE SCLEROSIS - The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient. Further, the present invention relates to the use of a polynucleotide or a polynucleotide set for detecting a miRNA to determine whether a patient responds to a therapeutic treatment of multiple sclerosis, to monitor the course of multiple sclerosis in a patient, to determine the risk of a relapse of multiple sclerosis in a patient, to adjust the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, and to identify a compound suitable for the treatment of multiple sclerosis in a patient. Furthermore, the present invention relates to a kit for determining whether a patient responds to a therapeutic treatment of multiple sclerosis, for monitoring the course of multiple sclerosis in a patient, for determining the risk of a relapse of multiple sclerosis in a patient, for adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, or for identifying a compound suitable for the treatment of multiple sclerosis in a patient comprising means for determining the level of at least one miRNA in a test sample isolated from a patient. | 2020-01-23 |
20200024668 | TUMOR SUPPRESSOR REC8 AS A BIOMARKER FOR GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status. | 2020-01-23 |
20200024669 | GENOMIC STABILITY PROFILING - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide potential benefit or potential lack of benefit for the disease. Molecular profiling can include biomarkers for immune checkpoint therapy, including microsatellite instability, tumor mutational burden, mismatch repair, and expression of checkpoint proteins such as PD-L1. | 2020-01-23 |
20200024670 | DIAGNOSTIC MARKERS - The present invention provides methods of predicting response to a cancer therapy based on the methylation status of the ERBB2 gene. One aspect of the invention provides a method of predicting response to an EGFR inhibitor therapy based on the methylation status of the ERBB2 gene. | 2020-01-23 |
20200024671 | MUTATIONS OF THE PIK3CA GENE IN HUMAN CANCERS - Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target. | 2020-01-23 |
20200024672 | METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES - Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. | 2020-01-23 |
20200024673 | CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE - Pharmaceutical compositions comprising spray-dried oxalate decarboxylase crystals are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using compositions comprising spray-dried oxalate decarboxylase crystals are also disclosed. | 2020-01-23 |
20200024674 | BIO-DEGRADABLE COMPOSITION AND/OR PROBIOTIC BIOCHEMICALS AND METHODS OF USE IN LEATHER TANNING PROCESSES - Use of probiotic technology to support tanners to reduce waste and increase the value of by-products reducing the need of synthetic chemicals, improving the quality of effluents and reducing the carbon footprint to the environment. Probiotics or beneficial microorganisms are used to obtain biochemicals through a controlled fermentation of natural ingredients. The result of the process is a consortium of metabolites including viable probiotic microorganisms with properties very similar to traditional leather auxiliaries extensively needed during leather production, eliminating or reducing the need for use of toxic chemicals and compositions. | 2020-01-23 |
20200024675 | ANIMAL HIDE DEHAIRING METHODS - Methods for preparing an animal hide for chrome tanning are provided. In particular, one or more embodiments include treating the hide with a first enzyme, a second enzyme, and a polysulfide. This treatment facilitates improved removal of hair from the hide. Furthermore, one or more embodiments include various combinations of treating the hide with a third enzyme, a liming agent, a pH-modifying agent, one or more sulfides, and one or more soaking agents. In addition, one or more embodiments include sanitizing the hide and liming the hide to further facilitate the processing of the animal hide into leather. | 2020-01-23 |
20200024676 | COOLING PLATE FOR METALLURGICAL FURNACE - A cooling plate for a metallurgical furnace including a body with a front face and an opposite rear face, the body having at least one cooling channel therein having an opening in the rear face and a coolant feed pipe connected to the rear face of the cooling panel and is in fluid communication with the cooling channel where in use, the front face is turned towards a furnace interior, and at least one emergency cooling tube is arranged within the cooling channel, the emergency cooling tube having a cross-section smaller than a cross-section of the cooling channel, the emergency cooling tube has an end section with connection means for connecting an emergency feed pipe thereto, and in an emergency operation, the emergency cooling tube is physically connected to an emergency feed pipe via the connection means; while, in a normal operation, the connection means of the emergency cooling tube is physically disconnected from the emergency feed pipe. The invention also concerns the use of such a cooling plate. | 2020-01-23 |
20200024677 | COPPER COOLING PLATE WITH MULTILAYER PROTRUSIONS COMPRISING WEAR RESISTANT MATERIAL, FOR A BLAST FURNACE - A cooling plate for use in a blast furnace is described. The cooling plate has a copper body having an inner face containing ribs parallel therebetween, having first extremities and separated by grooves having second extremities. At least one of these grooves containing at least a part of a multilayer protrusion extending between its second extremities and having at least one layer made of a wear resistant material that increases locally the wear resistance of the neighboring ribs. | 2020-01-23 |
20200024678 | COOLING PANEL FOR METALLURGICAL FURNACE - A cooling panel for a metallurgical furnace includes a body with a front face and an opposite rear face, a top face and an opposite bottom face and two opposite side faces. The body has at least one cooling channel therein, the cooling channel having openings in the rear face; wherein, in use, the front face of the body is turned towards a furnace interior. According to the invention, the cooling panel having at least one cooling pipe arranged in at least one elongate recess formed in the front face, where the cooling pipe has an elongate middle section and at either end thereof, an angled branch, the cooling pipe forming the cooling channel, and where the cooling pipe is arranged in the elongate recess such that the angled branches protrude through the openings in the rear face of the body. | 2020-01-23 |
20200024679 | HOT ROLLED STEEL SHEET, STEEL FORGED PART AND PRODUCTION METHOD THEREFOR - A hot rolled steel sheet having a chemical composition consisting of, in mass %, C: 0.020-0.070%, Si: 0.05-1.70%, Mn: 0.60-2.50%, Al: 0.005-0.020%, N: >0.0030-0.0060%, P≤0.050%, S≤0.005%, Ti: 0.015-0.170%, Nb: 0-0.100%, V: 0-0.300%, Cu: 0-2.00%, Ni: 0-2.00%, Cr: 0-2.00%, Mo: 0-1.00%, B: 0-0.0100%, Ca: 0-0.0100%, Mg: 0-0.0100%, REM: 0-0.1000%, Zr: 0-1.000%, Co: 0-1.000%, Zn: 0-1.000%, W: 0-1.000%, Sn: 0-0.050%, the balance: Fe and impurities, wherein Ca+Mg+REM≥0.0005, a metal microstructure includes, in area %, ferrite: 5-70%, bainite: 30-95%, retained γ≤2%, martensite ≤2%, pearlite ≤1%, ferrite+bainite≥95%, a number density of the precipitates in ferrite grains is 1.0×10 | 2020-01-23 |
20200024680 | Steel Alloy and Method for Heat Treating Steel Alloy Components - A steel alloy including, by weight percent: Ni: 18 to 19%; Co: 11.5 to 12.5%; Mo: 4.6 to 5.2%; Ti: 1.3 to 1.6%; Al: 0.05 to 0.15%; Nb: 0.15 to 0.30%; B: 0.003 to 0.020%; Cr: max 0.25%; Mn: max 0.1%; Si: max 0.1%; C: max 0.03%; P: max 0.005%; and S: max 0.002%, the balance being iron plus incidental impurities. | 2020-01-23 |
20200024681 | STEEL SHEET FOR TWO-PIECE CAN AND MANUFACTURING METHOD THEREFOR - A steel sheet for a two-piece can, the steel sheet includes: by mass %, C: 0.010% or more and less than 0.050%; Si: 0.04% or less; Mn: 0.10% or more and less than 0.40%; P: 0.02% or less; S:0.020% or less; Al: more than 0.030% and 0.100% or less; N: 0.0005% or more and less than 0.0030%; B: 0.0005% to 0.0030%; and balance Fe and inevitable impurities, wherein an amount of N that is present as BN and a whole amount of N satisfy the following expression (1): | 2020-01-23 |
20200024682 | FERRITE-BASED STAINLESS STEEL SHEET HAVING LOW SPECIFIC GRAVITY AND PRODUCTION METHOD THEREFOR - This ferritic stainless steel sheet contains, by mass %: C: 0.001% to 0.020%; Si: 0.01% to 4.00%; Mn: 0.01% to 3.00%; P: 0.010% to 0.040%; S: 0.0001% to 0.0100%; Cr: 10.0% to 15.0%; N: 0.001% to 0.020%; Al: 0.50% to 10.0%; and either one or both of Ti: 0.05% to 0.40% and Nb: 0.05% to 0.40%, with the balance being Fe and unavoidable impurities, in which Cr/(Si+Al) is 10.0 or less, and a specific gravity is 7.6 g/cm | 2020-01-23 |
20200024683 | HOT ROLLED STEEL SHEET - A hot rolled steel sheet including a chemical composition consisting of, in mass %, C: 0.07-0.22%, Si: 1.00-3.20%, Mn: 0.80-2.20%, Al: 0.010-1.000%, N≤0.0060%, P≤0.050%, S≤0.005%, Ti: 0-0.150%, Nb: 0-0.100%, V: 0-0.300%, Cu: 0-2.00%, Ni: 0-2.00%, Cr: 0-2.00%, Mo: 0-1.00%, B: 0-0.0100%, Mg: 0-0.0100%, Ca: 0-0.0100%, REM: 0-0.1000%, Zr: 0-1.000%, Co: 0-1.000%, Zn: 0-1.000%, W: 0-1.000%, Sn: 0-0.050%, the balance: Fe and impurities, wherein a metal microstructure includes, in area %, at a position ¼ W or ¾ W from an end face of the steel sheet and ¼ t or ¾ t from a surface, retained austenite: more than 2%-10%, martensite ≤2%, bainite: 10-70%, pearlite ≤2%, the balance: ferrite, an average circle-equivalent diameter of a metallic phase constituted of retained austenite/martensite is 1.0 to 5.0 μm, an average of minimum distances between adjacent metallic phases is 3 μm or more, and a standard deviation of nano hardness is 2.5 GPa or less. | 2020-01-23 |
20200024684 | METHOD AND SYSTEM FOR DESULFURIZATION AND DEZINCIFICATION OF TAILINGS - A method for desulfurization and dezincification of tailings includes the step of passing tap water into a high oxidation reduction electrocatalytic water equipment to reduce the pH value of tap water to 1-2, mixing a specific ratio of the pH value 1-2 acid electrocatalytic water with low-quality high-sulfur iron in the tailings, heating the mixture to let H | 2020-01-23 |
20200024685 | METAL OXIDE SMELTING METHOD - Provided is a smelting method in which, for example, a metal oxide such as a nickel oxide ore including nickel oxide is used as a source material and is reduced with a carbonaceous reducing agent to obtain a reduced product, with which method efficient processing can be achieved. This metal oxide smelting method is, for example, a nickel oxide ore smelting method. Specifically, the method includes a reduction process step S | 2020-01-23 |
20200024686 | Combined Processing Method for Lithium Containing Solutions - A combined processing method for the purification of lithium containing solutions, the method comprising the method steps of passing a lithium containing solution to a first purification step in which the lithium containing solution is contacted with a titanate adsorbent whereby lithium ions are adsorbed thereon whilst rejecting substantially all other cations, the recovery of lithium from the adsorbent providing a part-purified lithium containing solution, the part-purified lithium containing solution produced in the first purification step is then passed in whole or part to a second purification step in which a graphene based filter medium is utilised to provide a further purified lithium containing solution. | 2020-01-23 |
20200024687 | METHOD FOR EXTRACTING AND SEPARATING ZIRCONIUM AND HAFNIUM IN NITRIC ACID MEDIUM - A method for extracting and separating zirconium and hafnium in nitric acid medium mainly includes extraction of acidic raw liquid containing zirconium compounds with a synergistic extraction system consisting of DIBK and a phosphonic acids extraction agent, so that the zirconium goes to the aqueous phase and the hafnium goes to the organic phase, thus achieving separation. There is no need of use of toxic substance throughout the process. | 2020-01-23 |
20200024688 | METHOD FOR RECOVERING URANIUM FROM COMPONENTS CONTAMINATED WITH URANIUM OXIDE - A process for recovering uranium from components contaminated with uranium oxide includes providing a cleaning apparatus with a cleaning solution for dissolving the uranium oxide of the components, carrying out a cleaning process by introducing a batch of components into the cleaning apparatus, and carrying out a measurement for determining the uranium content of the components. The cleaning and the measuring are repeated if a limit value for the uranium content is exceeded. The components are discharged from the process if the uranium content falls below a limit value. The cleaning is carried out on a plurality of successive batches of components until a control measurement indicates an unsatisfactory cleaning action of the cleaning solution. The uranium oxide dissolved in the cleaning solution is recovered after indication of the unsatisfactory cleaning action. | 2020-01-23 |
20200024689 | ALUMINUM BASED NANOGALVANIC COMPOSITIONS USEFUL FOR GENERATING HYDROGEN GAS AND LOW TEMPERATURE PROCESSING THEREOF - Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components. | 2020-01-23 |
20200024690 | COPPER ALLOY PRODUCTION METHOD AND METHOD FOR MANUFACTURING FOIL FROM COPPER ALLOY - The present invention relates to a copper alloy production method and a method for manufacturing foil from a copper alloy, and the copper alloy production method of the present invention includes: a metal oxide preparing process of preparing at least two metals, including copper, each of which is in the form of a metal oxide, a nano powder producing process of pulverizing the metal oxides to produce metal oxide nano powder having a nano size, and an alloy producing process of heat-treating the metal oxide nano powder to produce an alloy, whereby, when a copper alloy is produced, precipitates can be minimized, the characteristics of the alloy can be optimized, and the generation of oxides on the outer wall of a molten metal furnace can be suppressed. | 2020-01-23 |
20200024691 | METAL MEMBER AND MANUFACTURING METHOD THEREOF - A metal member related to the present invention is provided with crystal grains of a metal and a granular reinforcing substance formed at boundaries of the crystal grains. The reinforcing substance includes grains of a shape with a grain area equivalent grain size larger than 1/100 of a grain area equivalent grain size of the crystal grains. The granular reinforcing substance preferably includes grains with a grain area equivalent grain size smaller than ⅕ of the grain area equivalent grain size of the crystal grains. Additionally, the granular reinforcing substance preferably includes grains of a shape wherein a value of a length, in a first direction in which a length thereof is longest, divided by a length of a longest part in a direction orthogonal to the first direction is smaller than 5. A metal member with a high strength at high temperatures is manufactured by metal powder injection molding. | 2020-01-23 |
20200024692 | METHOD OF CREATING POROUS STRUCTURES BY PARTICLE EXPANSION - A process for producing a metal foam. The process includes mechanically working a metallic powder such that oxide particles and/or dissolved oxygen are finely dispersed within a metallic matrix of the metallic particles that make up the metallic powder. The mechanically worked metallic powder is then annealed in a reducing atmosphere, where the reducing atmosphere is an atmosphere that results in the reduction of oxide and/or dissolved oxygen into vapor or gas molecules such that intraparticle porosity is formed within the metallic matrix by conversion of the oxide particles and/or dissolved oxygen to create vapor or gas molecules. | 2020-01-23 |
20200024693 | MM'X-Y METAL COMPOSITE FUNCTIONAL MATERIAL AND PREPARATION METHOD THEREOF - An MM′X—Y metal composite functional material and a preparation method thereof; an MM′X—Y metal composite functional material, comprising the following components in percentage by volume: A% of M | 2020-01-23 |
20200024694 | Lubricant-Compatible Copper Alloy - A copper alloy having a high corrosion resistance for a wide range of different lubricants, in particular different base oils and a variation of lubricant additives. The property of a low corrosion tendency for different tribological systems is also combined with good mechanical properties, and a high strength in particular. The alloy has a low wear and coefficient of friction. The lubricant-compatible copper alloy is suitable for producing components that come in contact with lubricant and are exposed to friction stresses, such as gear components, for example synchronizer rings. A method for manufacturing such components and a gear having at least one such component is also disclosed. | 2020-01-23 |
20200024695 | COPPER ALLOY STRIP EXHIBITING IMPROVED DIMENSIONAL ACCURACY AFTER PRESS-WORKING - Provided is a Corson alloy having improved bending workability and also having high dimensional accuracy after press-working. A copper alloy strip which is a rolling material, the rolling material containing from 0 to 5.0% by mass of Ni or from 0 to 2.5% by mass of Co, the total amount of Ni+Co being from 0.2 to 5% by mass; from 0.2 to 1.5% by mass of Si, the balance being copper and unavoidable impurities, wherein the rolling material satisfies the relationship: A | 2020-01-23 |
20200024696 | TITANIUM ALLOY - According to one embodiment, an alpha-beta titanium alloy comprises, in weight percentages: an aluminum equivalency in the range of about 6.7 to 10.0; a molybdenum equivalency in the range of 0 to 5.0; at least 2.1 vanadium; 0.3 to 5.0 cobalt; titanium; and incidental impurities. | 2020-01-23 |
20200024697 | TITANIUM ALLOY - According to one embodiment, an alpha-beta titanium alloy comprises, in weight percentages: an aluminum equivalency in the range of about 6.7 to 10.0; a molybdenum equivalency in the range of 0 to 5.0; at least 2.1 vanadium; 0.3 to 5.0 cobalt; titanium; and incidental impurities. | 2020-01-23 |
20200024698 | High Strength Titanium Copper Strip and Foil Having Layered Structure - A titanium copper according to the present invention contains from 1.5 to 5.0% by mass of Ti, the balance being of Cu and inevitable impurities, wherein the titanium copper has a layered structure of Cu and Ti where in a Ti concentration curve obtained by analyzing a cross section parallel to a rolling direction along a thickness direction by STEM-EDX, a lower concentration Ti layer having a Ti concentration less than an average value of Ti concentrations in the Ti concentration curve and a higher concentration Ti layer having a Ti concentration equal to or higher than the average value of the Ti concentrations in the Ti concentration curve are alternately present in the thickness direction, and wherein in the cross section parallel to the rolling direction, a Ti concentration difference in the layered structure is 3% by mass or more, the Ti concentration difference being a difference between a maximum value of the Ti concentration in the higher concentration Ti layer and a minimum value of the Ti concentration in the lower concentration Ti layer. | 2020-01-23 |
20200024699 | NICKEL BASE SUPER ALLOYS AND METHODS OF MAKING THE SAME - Methods of forming an intermediate alloy and a Ni-base super alloy are disclosed along with the intermediate alloy and the Ni-base super alloy formed by the method. The method includes at least partially melting and solidifying a powder including about 5 to 15 wt. % of Co, 10 to 20 wt. % of Cr, 3 to 6 wt. % of Mo, 3 to 6 wt. % of W, 2 to 4 wt. % of Al, 4.2 to 4.7 wt. % of Ti, 0.01 to 0.05 wt. % of Zr, 0.015 to 0.060 wt. % of C, 0.001 to 0.030 wt. % of B and balance substantially Ni to form an intermediate alloy including a dendrite structure that includes columnar regions and intercolumnar regions and a primary dendrite arm spacing less than about 3 micrometers. The intermediate alloy is heat-treated to form the texture-free Ni-base super alloy. | 2020-01-23 |
20200024700 | ALUMINUM WITH GRAIN REFINERS, AND METHODS FOR MAKING AND USING THE SAME - We have developed a scalable approach to directly incorporate grain-refining nanoparticles into conventional hot-tear-susceptible pure aluminum or aluminum alloy powders. These aluminum alloy powders may be additively manufactured into high-strength, crack-free aluminum alloys with fine equiaxed microstructures by incorporating nanoparticle nucleants to control solidification during additive manufacturing. Some variations provide an additively manufactured aluminum alloy comprising aluminum and at least one grain-refining element, wherein the additively manufactured aluminum alloy has a microstructure with equiaxed grains. Pure aluminum or aluminum alloys, combined with grain refiners, are useful in many processes beyond additive manufacturing. Some variations provide an aluminum alloy comprising aluminum and grain-refining nanoparticles selected from zirconium, tantalum, niobium, or titanium, wherein the aluminum alloy has a microstructure that is substantially crack-free with equiaxed grains. | 2020-01-23 |
20200024701 | THERMOELECTRIC COMPOSITIONS AND METHODS OF FABRICATING HIGH THERMOELECTRIC PERFORMANCE MgAgSb-BASED MATERIALS - Systems and methods of manufacturing a thermoelectric, high performance material by using ball-milling and hot pressing materials according to various formulas, where some formulas substitute a different element for part of one of the elements in the formula, in order to obtain a figure of merit (ZT) suitable for thermoelectric applications. | 2020-01-23 |
20200024702 | CEMENTED CARBIDE CONTAINING TUNGSTEN CARBIDE AND IRON ALLOY BINDER - A sintered cemented carbide body including tungsten carbide, and a substantially cobalt-free binder including an iron-based alloy sintered with the tungsten carbide. The iron-based alloy is approximately 2-25% of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may be approximately 90 wt % and the iron-based alloy may be approximately 10 wt % of the overall weight percentage of the sintered tungsten carbide and iron-based alloy. The tungsten carbide may comprise a substantially same size before and after undergoing sintering. The iron-based alloy may be sintered with the tungsten carbide using a uniaxial hot pressing process, a spark plasma sintering process, or a pressureless sintering process. The sintered tungsten carbide and iron-based alloy has a hardness value of at least 15 GPa and a fracture toughness value of at least 11 MPa√m. | 2020-01-23 |
20200024703 | NICKEL AND CHROME BASED IRON ALLOY HAVING ENHANCED HIGH TEMPERATURE OXIDATION RESISTANCE - A nickel- and chrome-rich highly heat-resistant, austenitic iron based alloy. The alloy exhibits an improved fine dendritic carbide structure and can withstand repeated thermal elongation and strain which is particularly important for an exhaust-gas turbocharger component exposed to exhaust gas flow, such as a turbine housing. The alloy also guarantees very good thermo-mechanical fatigue (TMF) loading performance. A thermal cracking problem of the component is significantly reduced. The alloy is influenced by the relationship between the elements nickel, niobium, cerium and vanadium. The invention further concerns a method for prevention of crack formation and for minimizing oxidization in a turbocharger turbine housing. | 2020-01-23 |
20200024704 | Metal Powder For Powder Metallurgy, Compound, Granulated Powder, And Sintered Body - A metal powder for powder metallurgy contains Fe as a principal component, Cr in a proportion of 11.0 mass % or more and 25.0 mass % or less, Ni in a proportion of 8.0 mass % or more and 30.0 mass % or less, Si in a proportion of 0.20 mass % or more and 1.2 mass % or less, C in a proportion of 0.070 mass % or more and 0.40 mass % or less, Mn in a proportion of 0.10 mass % or more and 2.0 mass % or less, P in a proportion of 0.10 mass % or more and 0.50 mass % or less, and at least one of W and Nb in a proportion of 0.20 mass % or more and 3.0 mass % or less in total. | 2020-01-23 |