04th week of 2020 patent applcation highlights part 20 |
Patent application number | Title | Published |
20200024204 | METHOD AND COMPOSITION - A method of producing a fertiliser composition, the method comprising:
| 2020-01-23 |
20200024205 | Compositions for Increasing Nitrogen Sources Life Span in Plant Growth Mediums and Methods of Making - The present invention relates to compositions for increasing a nitrogen source life span in plant growth mediums as well as methods of making these compositions. The invention also relates to compositions and methods of reacting a nitrogen source with one or more nitrification inhibitors using standard equipment for producing nitrogen sourced particles. | 2020-01-23 |
20200024206 | AQUEOUS SUSPENSION FOR AGRONOMIC USE - An aqueous suspension includes, in weight percent with respect to the total weight of the suspension, at least 10% of at least one metal in the form of salt and/or oxide and/or hydroxide, at least 3.5% of at least one polyphenol and from 0.05 to 10% of at least one dispersing agent. A process for the production of an aqueous suspension includes, in weight percent with respect to the total weight of the suspension, at least 10% of at least one metal in the form of salt and/or oxide and/or hydroxide, at least 3.5% of at least one polyphenol and from 0.05 to 10% of at least one dispersing agent, which includes a mixing step of the at least one metal, the at least one polyphenol, the at least one dispersing agent, and any other further components in water. The aqueous suspension can be used as fertilizer and/or phytoprotective agent of a plant by application of the aqueous suspension of the invention to the plant. | 2020-01-23 |
20200024207 | METHOD OF PROMOTING BACILLUS SPORE GERMINATION - The present invention provides a method of promoting spore germination and/or vegetative growth of a plant growth-promoting | 2020-01-23 |
20200024208 | ORGANIC FLOCCULANT AND FERTILIZER - Provided herein is technology relating to organic fertilizers and particularly, but not exclusively, to organic and/or biodegradable flocculants, methods of preparing organic fertilizers using an organic and/or biodegradable flocculant, and systems for treating water using an organic and/or biodegradable flocculant to prepare an organic fertilizer. | 2020-01-23 |
20200024209 | ORGANIC SLOW-ACTING FERTILIZER USING PLANTAGINIS SEMEN HUSK AND MANUFACTURING METHOD THEREFOR - The present invention provides organic slow-acting fertilizer using psyllium seed husk and a method for producing the same. Macroelements or secondary elements selected from 12 essential nutrient elements (N, P, K, Ca, Mg, S, Fe, Mn, Cu, B, Mo, and Zn) for edible plants are extracted from each of oil cake (collectively referring to residue remaining after extraction of vegetable oil, and including soybean oil cake, palm oil cake, etc.), blood meal (livestock blood), dead fish or bonefish-containing by-products, bone meal, Dead Sea mineral, egg shell, seashell, oystershell, natural gypsum, dolomite, phyllite, and natural salt, by a predetermined extraction process, and are impregnated in larger amounts into a porous material such as zeolite, and organic fertilizers are produced in the form of psyllium seed husk-bound grains for more rapid and effective impregnation so that suitable proportions of element fertilizers can be supplied to each type of plant. | 2020-01-23 |
20200024210 | SOLID PROPELLANT ADDITIVE MANUFACTURING SYSTEM - A system is used for additively manufacturing propellant elements, such as for rocket motors, includes partially curing a propellant mixture before extruding or otherwise dispensing the material, such that the extruded propellant material is deposited on the element in a partially-cured state. The curing process for the partially-cured extruded material may be completed shortly after the material is put into place, for example by the material being heated at or above its cure temperature, such that it finishes curing before it fully cools. The propellant material may be prepared by first mixing together, a fuel, an oxidizer, and a binder, such as in an acoustic mixer. After that mixing a curative may be added to the mixture. The propellant mixture may then be directed to an extruder (or other dispenser), in which the mixture is heated to or above a cure temperature prior to the deposition, and then deposited. | 2020-01-23 |
20200024211 | PYROTECHNIC DELAY COMPOSITION - A pyrotechnic delay composition comprising at least one oxidant and at least one reducing agent. This composition comprises tungsten as the first reducing agent, a first oxidant consisting of triiron tetraoxide, and a second oxidant having an oxygen content greater than that of the first oxidant. | 2020-01-23 |
20200024212 | METHODS AND SYSTEMS FOR AN EXPLOSIVE CORD - Methods and systems for an explosive cord are disclosed. An explosive cord may comprise a tubing comprising an inner surface and an outer surface, a reactive material comprising hexanitrostilbene and/or boron potassium nitrate coupled to the inner surface of the tubing, and a hollow or solid core through the center of the explosive cord. | 2020-01-23 |
20200024213 | METHOD FOR STABLE OPERATION OF MICROPOROUS STRUCTURES IN AN OXYGENATE CONVERSION PROCESS - A process for converting oxygenates to hydrocarbons includes introducing a feed stream having at least one oxygenate into a reaction zone, and introducing a hydrogen gas stream into the reaction zone. In the reaction zone the feed stream and the hydrogen gas stream are simultaneously contacted with a catalyst, and the catalyst includes a solid microporous acid component having 8-MR to 10-MR access. The hydrogen gas stream in the reaction zone has a partial pressure from 1 bar (100 kPa) to 48 bar (4800 kPa), and the reaction zone is at a temperature from 350° C. to 500° C. | 2020-01-23 |
20200024214 | CATALYTIC FORMS AND FORMULATIONS - Catalytic forms and formulations are provided. The catalytic forms and formulations are useful in a variety of catalytic reactions, for example, the oxidative coupling of methane. Related methods for use and manufacture of the same are also disclosed. | 2020-01-23 |
20200024215 | CATALYSTS FOR THE OXIDATIVE DEHYDROGENATION OF ALKANES - This document relates to oxidative dehydrogenation catalysts that include molybdenum, vanadium, and oxygen. | 2020-01-23 |
20200024216 | INTEGRATED PROCESSES FOR PARA-XYLENE PRODUCTION - Para-xylene production processes are disclosed, with such processes being integrated with extractive distillation or other separation to effectively separate, for example to remove and recover, ethylbenzene and other components that co-boil with the isomers of xylene. This allows for xylene isomerization, downstream of the separation of para-xylene from its other isomers, to be operated under milder conditions (e.g., liquid phase, absence of added hydrogen) without the need for ethylbenzene conversion. The associated decreased yields of byproducts such as light gases and non-aromatic hydrocarbons, together with the generation of purified ethylbenzene having value for styrene monomer production, can significantly improve overall process economics. | 2020-01-23 |
20200024217 | PROCESS FOR THE SEPARATION OF ETHYLBENZENE FROM OTHER C8 AROMATIC COMPOUNDS - Extractive agent compounds are disclosed, with exemplary compounds having Formula (I): | 2020-01-23 |
20200024218 | METHOD FOR PRODUCING 1-CHLORO-3,3,3-TRIFLUOROPROPENE - A method for manufacturing 1-chloro-3,3,3-trifluoropropene (1230zd) is provided. The method includes contacting a halogenated hydrocarbon compound having a carbon number of 3 and represented by a general formula (1) with a metal catalyst in a gas phase. | 2020-01-23 |
20200024219 | CARBOXYLATE SALT OR SULFONATE SALT, AND SURFACTANT - A carboxylic acid or sulfonic acid salt containing a plurality of carbonyl groups, and a surfactant represented by the following formula: | 2020-01-23 |
20200024220 | METHOD FOR PREPARING 2-ARYL MALONAMIDE AND APPLICATIONS THEREOF - Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production. | 2020-01-23 |
20200024221 | METHYLMENTHOL DERIVATIVE AND COOL-SENSATION IMPARTER COMPOSITION CONTAINING SAME - A cooling agent composition includes a methyl menthol derivative represented by the following general formula (1). In the formula (1), a symbol * indicates an asymmetric carbon atom, X represents a hydrogen atom or a substituent, and Y represents an aryl group having 6 to 20 carbon atoms which may have a substituent. | 2020-01-23 |
20200024222 | HYDROCARBON-CONTAINING CARBOXYLIC ACID, HYDROCARBON-CONTAINING SULFONIC ACID, HYDROCARBON-CONTAINING SULFURIC ACID ESTER OR SALT THEREOF, AND SURFACTANT - The invention provides a novel hydrocarbon-containing carboxylic acid, hydrocarbon-containing sulfonic acid, hydrocarbon-containing sulfuric acid ester, or a salt thereof, and a surfactant. Each of them is a compound represented by the following formula (1): | 2020-01-23 |
20200024223 | CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(ME- THYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-- 2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME - A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed. | 2020-01-23 |
20200024224 | ANTIFUNGAL COMPOUNDS AND METHODS OF FORMING THE SAME - An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof. | 2020-01-23 |
20200024225 | CLEANING DEVICE FOR GAS FLOWS FROM ISOCYANATE PRODUCTION - The invention relates to a cleaning device for separating an organic isocyanate produced by the reaction of an organic amine with a stoichiometric excess of phosgene in the gas phase from the gaseous raw product obtained in the reaction, said device comprising a first separating body comprising at least one raw product supply line for a gaseous raw product flow containing at least the isocyanate, hydrogen chloride and non-reacted phosgene, a first liquid supply line for a liquid flow containing at least one quench liquid, and a first liquid discharge line for a liquid flow containing at least part of the quench liquid and part of the isocyanate, a first gas line for transporting a gas flow containing at least hydrogen chloride, evaporated quench liquid and phosgene leading away from the first separating body. The invention is characterized in that at least one addition body for directly introducing at least one cooling fluid for an at least partial condensation and/or absorption of the gas flow that can be guided via the first gas line is associated with the first gas line. | 2020-01-23 |
20200024226 | SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME - The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors. | 2020-01-23 |
20200024227 | INTEGRATED PROCESS FOR PRODUCTION OF GLYCEROL CARBONATE (4-HYDROXYMETHYL-2-OXO-1, 3-DIOXOLANE) AND UREA - Systems and methods for integrated glycerol carbonate and/or urea production. This disclosure pertains to development of a process for production of glycerol carbonate and/or urea from ammonia, carbon dioxide and glycerol. The process integrates glycerol carbonate production into a urea production process. The urea produced in the production facility may be used to produce glycerol carbonate by reacting urea with glycerol. The ammonia generated by glycerol carbonate production may be recycled back to urea production. Unreacted urea from the glycerol carbonate production may be separated and recycled to the urea product stream. The systems and methods can reduce the cost for urea production and increase product value of the excessive glycerol produced from other chemical plants. | 2020-01-23 |
20200024228 | NEW METHOD FOR PRODUCING 2-ACRYLAMIDO-2-METHYLPROPANE SULPHONIC ACID - The present invention relates to a production process for 2-acrylamido-2-methylpropane sulfonic acid including at least the following successive steps:
| 2020-01-23 |
20200024229 | SULFONIC ACID, CARBOXYLIC ACID, AND SALTS THEREOF - A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula: | 2020-01-23 |
20200024230 | PGAM1 Inhibitors and Methods Related Thereto - In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof. | 2020-01-23 |
20200024231 | (+)-3-(2,3-DIFLUOROPHENYL)-3-METHOXYPYRROLIDINE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR PREPARATION THEREOF AND USES THEREOF - The disclosure provides a process for manufacturing thereof a salt of Formula IIb: | 2020-01-23 |
20200024232 | METHODS OF PURIFICATION OF 2-ARYL-3,3-BIS(4-HYDROXYARYL)PHTHALIMIDINES, AND POLYMERS DERIVED THEREFROM - A method for the purification of a 2-aryl-3,3-bis(hydroxyaryl)phthalimidine of formula (I), the method comprising heating a reaction mixture comprising a phenolphthalein compound of formula (II) and a primary arylamine of formula (III) in the presence of an acid catalyst to form a reaction mixture; removing water from the reaction mixture; quenching the reaction mixture with an aqueous alkali solution to form a quenched reaction mixture; extracting the quenched reaction mixture with an aminoaryl compound of formula (IV) to form an organic layer and an extracted aqueous layer comprising a crude 2-aryl-3,3-bis(hydroxyaryl)phthalimidine compound; contacting the extracted aqueous layer with carbon to form a semi-purified 2-aryl-3,3-bis(hydroxyaryl)phthalimidine compound; and mixing the semi-purified 2-aryl-3,3-bis(hydroxyaryl)phthalimidine compound with a solution comprising an alcohol and an acid to form a purified 2-aryl-3,3-bis(hydroxyaryl)phthalimidine of formula (I); wherein formulas (I), (II), (III), and (IV) are as provided herein. | 2020-01-23 |
20200024233 | SULFINYLPYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER - There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R | 2020-01-23 |
20200024234 | RADIOPHARMACEUTICAL COMPLEXES - The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications. | 2020-01-23 |
20200024235 | CRYSTAL FORM AND SALT FORM OF AND PREPARATION METHOD FOR TYROSINE KINASE INHIBITOR - Disclosed are a crystal form and a salt form of and a preparation method for a tyrosine kinase inhibitor. | 2020-01-23 |
20200024236 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN DIOXYGENASE - The present invention relates to bicyclic compounds and compositions and methods which may be useful as inhibitors of IDO1, IDO2, and TDO for the treatment or prevention of diseases such as cancer. | 2020-01-23 |
20200024237 | PRODUCTION METHOD FOR AMIDATE COMPOUND - A method for producing an amidate compound represented by Formula (3), comprising reacting a urethane compound represented by Formula (1) with a carboxylate compound represented by Formula (2): | 2020-01-23 |
20200024238 | 5-FLUORO-4-IMINO-3(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR THEIR PREPARATION - Provided herein are 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation which may include the use of an alkali carbonate and an alkylating agent | 2020-01-23 |
20200024239 | Elagolix Sodium Compositions and Processes - The present invention relates to compositions of elagolix sodium, and process and intermediates for the preparation thereof. | 2020-01-23 |
20200024240 | BARBITURIC ACID DERIVATIVES COMPRISING CATIONIC AND LIPOPHILIC GROUPS - The present invention relates to bioactive cyclic compounds and their use as antimicrobial agents. In particular, the present invention relates to barbiturate mimics of Eusynstyelamides or small antimicrobial peptides. The compounds of the invention are represented by Formula (I). (I) | 2020-01-23 |
20200024241 | NOVEL COMPOUND HAVING ISOCYANURIC SKELETON AND COMPOSITION IN WHICH SAID COMPOUND IS INCLUDED - The invention aims to provide a novel compound to be suitably used for antifouling agents. The compound of the invention is represented by the following formula (1): | 2020-01-23 |
20200024242 | LOW-ENERGY CONSUMPTION PROCESS WITH REDUCED AMMONIA CONSUMPTION, FOR THE PRODUCTION OF HIGH-PURITY MELAMINE THROUGH THE PYROLYSIS OF UREA, AND RELATIVE PLANT - A process is described, having a low-energy consumption and reduced ammonia consumption for the production of high-purity melamine, through the pyrolysis of urea, and the relative plant. | 2020-01-23 |
20200024243 | Heat-resistant polylactic acid continuously-extruded foamed material and preparation method thereof - An ethylene bis-12-hydroxystearamide grafted glycidyl citrate (EBH-g-ECA) and a preparation method thereof are provided; the EBH-g-ECA can be used as a multifunctional auxiliary agent in a polymer material, and particularly has a chain extension and a crystal nucleation effect in a polyester polymer material. A heat-resistant polylactic acid continuously-extruded foamed material containing EBH-g-ECA is further provided. The continuous foaming technology can be realized by using the heat-resistant polylactic acid foamed material, and the prepared foamed product has a high heat resistance, a uniform appearance, a low density, and complete biodegradation. A polylactic acid foamed material preparation method for a heat-resistant is provided, which is easy to be industrialized and has a great significance for realizing the large-scale replacement of petroleum-based plastic disposable foamed products such as PP and PS. | 2020-01-23 |
20200024244 | PROCESS FOR PREPARING D-GLUCARO-6,3-LACTONE - A process for preparing D-glucaro-6,3-lactone from a salt of D-glucaric acid is provided. The process includes: adding a mineral acid to a pre-cooled solution including a salt of D-glucaric acid, water, and acetone to obtain a crude mixture; allowing the crude mixture to rise to a temperature in a range of ≥15° C. to ≤35° C. and stirring the crude mixture; filtrating the crude mixture and washing with an acetone and water solvent mixture to obtain a filtrate; concentrating the filtrate under vacuum pressure to obtain a concentrated filtrate having a water content in a range of ≥20.0 wt. % to ≤40.0 wt. %, relative to an overall weight of the concentrated filtrate; storing the concentrated filtrate at a temperature in a range of ≥0° C. to ≤5° C., and optionally repeating the concentrating and storing steps to obtain a precipitate comprising D-glucaro-6,3-lactone. | 2020-01-23 |
20200024245 | COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE AND DISPLAY DEVICE - The disclosure relates to the field of organic electroluminescence technologies, in particular to a compound, an organic electroluminescent device and a display device. The compound has a structure as shown in Formula (I), | 2020-01-23 |
20200024246 | POGOSTONE DERIVATIVES AND METHODS OF USING THE SAME - Described are novel derivatives of pogostone and methods of using the same. | 2020-01-23 |
20200024247 | INHIBITORS OF THE IRE-1/XBP-1 PATHWAY AND METHODS OF USING THEREOF - Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model. | 2020-01-23 |
20200024248 | PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING THE SAME - Described herein are Δ | 2020-01-23 |
20200024249 | METHODS OF PROTECTING AGAINST NEURODEGENERATION - The disclosure provides a method of preventing or reducing protein aggregates using combretastatin-A4 (CA4) or an analog thereof. The disclosure also provides methods of reducing the risk, delaying the onset, delaying or slowing the progression, or reversing the signs or symptoms of a neurodegenerative (or other age-progressive) disease using a combretastatin-A4 (CA4) or an analog thereof. The combretastatin-A4 (CA4) or an analog thereof may bind glial fibrillary acidic protein (GFAP). The combretastatin-A4 (CA4) or an analog thereof is described by compounds of Formula (I). | 2020-01-23 |
20200024250 | PROCESS FOR PREPARATION OF APALUTAMIDE - The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide. | 2020-01-23 |
20200024251 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES - The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented. | 2020-01-23 |
20200024252 | ANTIFUNGAL COMPOUND PROCESS - The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7 or 7* and 11 or 11* and substituted derivatives thereof. | 2020-01-23 |
20200024253 | N-SUBSTITUTED BICYCLIC LACTAMS, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS - This application relates to N-substituted bicyclic lactams of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to the N-substituted bicyclic lactams of formula (I) and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers. | 2020-01-23 |
20200024254 | METHOD FOR PRODUCING OPTICALLY ACTIVE PYRROLIDINE COMPOUNDS - The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and water. | 2020-01-23 |
20200024255 | HETEROCYCLYLSULFONYL-SUBSTITUTED PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER - There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R | 2020-01-23 |
20200024256 | TETRAHYDRATE OF H3 LIGAND, ITS PROCESS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME - The present invention concerns the tetrahydrate form of the compound: (3S)-4-{4-[3-(3 -methylpiperidin-1-yl)propoxy]phenyl}pyridine 1-oxide, dihydrochloride, its process of preparation and therapeutical uses thereof. | 2020-01-23 |
20200024257 | ROR GAMMA MODULATORS - There are described RORγ modulators of the formula (I), | 2020-01-23 |
20200024258 | Triazinium Cation Forms and Methods of Making Thereof - The present disclosure provides, among other things, compounds and crystalline forms of compounds thereof and methods of making and using such compounds and crystalline forms of compounds. Disclosed compounds and crystalline forms are useful in electronic materials, semiconductor materials, and optoelectronic materials and devices incorporating these materials and which exhibit desirable characteristics for the same. | 2020-01-23 |
20200024259 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS - The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders. | 2020-01-23 |
20200024260 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS - Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. | 2020-01-23 |
20200024261 | DIFLUOROMETHYL-PHENYL TRIAZOLES - The present invention relates to difluoromethyl-phenyl triazoles of general formula (I) which are modulators of GABA | 2020-01-23 |
20200024262 | ENANTIOMERICALLY PURIFIED GPER ANGONIST FOR USE IN TREATING DISEASE STATES AND CONDITIONS - The present disclosure provides 1) an enantiomerically purified compound SRR G-1, or a derivative thereof, including specific crystal forms, salts and co-crystals that modulates G protein-coupled estrogen receptor activity, 2) pharmaceutical and cosmetic compositions comprising an enantiomerically purified SRR G-1, or a derivative thereof, and 3) methods of treating or preventing disease states and conditions and cosmetic conditions mediated through these receptors and related methods thereof in humans and animals. | 2020-01-23 |
20200024263 | COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE ELEMENT, ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ELECTRONIC DEVICE - A novel compound represented by formula (1): | 2020-01-23 |
20200024264 | NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES - The present invention covers new quinoline compounds of general formula (I) in which A, R | 2020-01-23 |
20200024265 | CARBOHYDRATE-BINDING SMALL MOLECULES WITH ANTIVIRAL ACTIVITY - Compounds with anti-viral properties are provided that are based on the following structures: | 2020-01-23 |
20200024266 | INHIBITORS OF CYCLIN-DEPENDENT KINASES - Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases. | 2020-01-23 |
20200024267 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF - Provided herein are compounds useful as inhibitors of CBX. Also described are pharmaceutical compositions and medical uses of these compounds. | 2020-01-23 |
20200024268 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL - Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer. | 2020-01-23 |
20200024269 | NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF - The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of estrogen-related diseases and conditions. | 2020-01-23 |
20200024270 | COMPOUNDS FOR TREATMENT OF CANCER - The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer. | 2020-01-23 |
20200024271 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF - The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I) or (II), or compositions thereof, for treating or preventing a wide range of diseases (e.g., proliferative diseases (e.g., cancers, benign neoplasms, angiogenesis, inflammatory diseases, autoimmune diseases) and metabolic diseases (e.g., diabetes (e.g., type 2 diabetes, gestational diabetes)) in a subject. Treatment of a subject with a disease using a compound of Formula (I) or (II), or compositions thereof, may downregulate the expression and/or inhibit the activity of a kinase (e.g., a tyrosine kinase, such as a Tec kinase, in particular, bone marrow on X chromosome kinase (BMX)), and therefore, suppress tyrosine kinase singling in the subject. | 2020-01-23 |
20200024272 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY - Compound of formula (I′) or (I″) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity. | 2020-01-23 |
20200024273 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1,5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES - Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby. | 2020-01-23 |
20200024274 | Divalent Nucleobase Compounds and Uses Therefor - Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a γ-peptide nucleic acid (γPNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a γPNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided. | 2020-01-23 |
20200024275 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 - Described are positive allosteric modulators of muscarinic acetylcholine receptor M | 2020-01-23 |
20200024276 | CAPSAZEPINE ANALOGS FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES - The present disclosure relates generally to derivatives of capsazepine and methods of use thereof. In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. | 2020-01-23 |
20200024277 | TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES AS LSD1 INHIBITORS - The present invention is directed to [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-a]pyrazine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer. | 2020-01-23 |
20200024278 | COMPOSITION COMPRISING ANTIBIOTIC COMPOUND AND AN HETEROCYCLIC COMPOUND AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS - A composition comprising:
| 2020-01-23 |
20200024279 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR - Compounds having a structure according to formula (I) | 2020-01-23 |
20200024280 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDGFR - Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein. | 2020-01-23 |
20200024281 | FURTHER SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES - The present invention relates to compounds according to general formula (I) | 2020-01-23 |
20200024282 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES - The present invention describes diazadibenzofuran or diazadibenzothiophene derivatives substituted by carbazole, fluorene, phenanthrene, benzofuran and/or benzothiophene groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these. | 2020-01-23 |
20200024283 | DERIVATIVES OF THAILANSTATIN A, METHODS OF TREATMENT AND METHODS OF SYNTHESIS THEREOF - In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. | 2020-01-23 |
20200024284 | THIENOISOQUINOLINES AND THEIR DERIVATIVES FOR THE TREATMENT OF CANCER - The present disclosure relates to fused N-arylsulfonamidyl-thienoisoquinoline compounds, derivatives and pharmaceutical compositions thereof, and methods and uses in inhibiting cancer cell growth, along with a supplemental anti-cancer agent. Centrosome targeting and microtubule depolymerisation are attractive in designing the present chemotherapeutic compounds. The various diseases and conditions treated include various types of cell cancers, and in vitro inhibition. | 2020-01-23 |
20200024285 | NOVEL CHROMONE OXIME DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and, furthermore, presents an advantageously high brain penetration upon oral administration. The invention also relates to a pharmaceutical composition containing this compound, and to its use for the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions, or conditions which can be affected by alteration of glutamate level or signalling, particularly acute and chronic neurological and/or psychiatric disorders. | 2020-01-23 |
20200024286 | FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS - Disclosed are compounds of Formula (I): | 2020-01-23 |
20200024287 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS - The present invention relates to a process for synthesizing a compound of formula (I), R | 2020-01-23 |
20200024288 | SOLID FORMS OF [(1 S)-1 -[(2S,4R,5R)-5-(5-AMINO-2-OXO-THIAZOLO[4,5-D]PYRIMIDIN-3-YL)-4-HYDROXY-TE- TRAHYDROFURAN-2-YL]PROPYL] ACETATE - The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection. | 2020-01-23 |
20200024289 | NOVEL OXABOROLE ANALOGS AND USES THEREOF - This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite. | 2020-01-23 |
20200024290 | Cu- and Ni-Catalyzed Decarboxylative Borylation Reactions - The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(11) salt or a copper salt, and an Mg(11) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009. | 2020-01-23 |
20200024291 | THIO(DI)SILANES - Thio(di)silanes comprising a thiosilane of formula (A): (R | 2020-01-23 |
20200024292 | MULTIFUNCTIONALIZED SILICON NANOPARTICLES, PROCESS FOR THEIR PREPARATION AND USES THEREOF IN ELECTROCHEMILUMINESCENCE BASED DETECTION METHODS - The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles. | 2020-01-23 |
20200024293 | PROCESS FOR PREPARATION OF O, O-DIMEHYL PHOSPHORAMIDOTHIOATE AND N-(METHOXY-METHYLSULFANYLPHOSPHORYL) ACETAMIDE - Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PCl | 2020-01-23 |
20200024294 | Organic metal compound and organic light-emitting device - Organic metal compounds and organic light-emitting devices employing the same are provided. The organic metal compound has a chemical structure of Formula (I) or Formula (II): | 2020-01-23 |
20200024295 | NANOPARTICLES AND PREPARATION METHOD - The present invention concerns a composite comprising supported nanoclusters, the nanoclusters comprising one or more metal ion-containing compounds, wherein each metal ion-containing compound is a transition metal complex having ligands coordinated to a transition metal ion, the ligands being selected from the group consisting of glyoxime; a glyoxime derivative; salicylaldimine; and a salicylaldimine derivative; and wherein the nanoclusters are spaced across one or more surfaces of a support; a material prepared from the composite by annealing; and solution-based methods for forming the composite and materials. Uses of the metal ion-containing compounds are also described, as are uses of the products as catalysts and adsorbers. | 2020-01-23 |
20200024296 | PROCESS FOR THE ISOLATION OF NOVEL GLYCOSIDES FROM PTEROCARPUS MARSUPIUM AND THEIR THERAPEUTIC EFFECTS - The present invention discloses a composition comprising not less than 5% w/w | 2020-01-23 |
20200024297 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF - Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. | 2020-01-23 |
20200024298 | PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM I - The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water | 2020-01-23 |
20200024299 | CRYSTALLINE FORMS OF A BILE ACID DERIVATIVE - A crystalline form of a bile acid compound and methods of preparation and use thereof are described. | 2020-01-23 |
20200024300 | C7 SUBSTITUTED OXYSTEROLS AND METHODS OF USE THEREOF - Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R | 2020-01-23 |
20200024301 | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS - Described herein are neuroactive steroids of the Formula (I); or a pharmaceutically acceptable salt thereof, wherein, R | 2020-01-23 |
20200024302 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF - Described herein are neuroactive steroids of the Formula (I): | 2020-01-23 |
20200024303 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described. | 2020-01-23 |