03rd week of 2016 patent applcation highlights part 25 |
Patent application number | Title | Published |
20160017369 | VECTOR COMPRISING MULTIPLE HOMOLOGOUS NUCLEOTIDE SEQUENCES - The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases. | 2016-01-21 |
20160017370 | DEVICE FOR INTRACELLULAR DELIVERY AND A METHOD THEREOF - A device for intracellular delivery includes a substrate having a diamond layer, and diamond nanoneedles that spaced apart from each other on the diamond layer, the substrate further comprises a silicon layer below the diamond layer, wherein the nanoneedles are cylindrical nanoneedles, and a side surface of the nanoneedles is perpendicular to the diamond layer. | 2016-01-21 |
20160017371 | STEM CELL GENE TARGETING - The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus. | 2016-01-21 |
20160017372 | METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES - Methods of inserting genes into defined locations in the chromosomal DNA of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and the sequence of interest. The invention also relates to meganucleases, vectors and engineered cell lines necessary for performing the methods, to cell lines resulting from the application of the methods, and use of the cell lines to produce protein products of interest. | 2016-01-21 |
20160017373 | Bulk Availability and Production of Bioremediation Products - A method for producing and storing a bioremediation product that includes active bacteria for bioremediation of hydrocarbon oil pollution includes storing the bioremediation product in bulk in ready-to-use form for later application at a pollution site. The bioremediation product has a typical shelf life of 2 years or more. | 2016-01-21 |
20160017374 | COMPOSITIONS AND METHODS FOR BIOLOGICAL PRODUCTION OF ISOPRENE - The present disclosure provides compositions and methods for biologically producing isoprene using methanotrophic bacteria that utilize carbon feedstock, such as methane or natural gas. | 2016-01-21 |
20160017375 | METHOD FOR COLLECTING ISOPRENOID COMPOUND CONTAINED IN FERMENTED GAS, AND METHOD FOR PRODUCING PURIFIED ISOPRENOID COMPOUND - Methods include contacting a fermented gas including isoprenoid compound with a porous adsorbent and desorbing isoprenoid compound adsorbed on the porous adsorbent. The fermented gas may be obtained by culturing a microorganism having an ability to produce isoprenoid compound. | 2016-01-21 |
20160017376 | METHOD FOR PREPARING D-CHIRO-INOSITOL USING MICROBES - The present invention relates to a method for preparing D-chiro-inositol from myo-inositol by using a transformed host cell which expresses enzymes such as a myo-inositol transporter, inositol dehydrogenase, and inosose isomerase. According to the method of the present invention, myo-inositol can be converted into D-chiro-inositol at a high yield. | 2016-01-21 |
20160017377 | METHODS FOR REGULATING NITROGEN METABOLISM DURING THE PRODUCTION OF ETHANOL FROM CORN BY METABOLICALLY ENGINEERED YEAST STRAINS - The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of | 2016-01-21 |
20160017378 | Process for producing lower alkyl alcohols from cellulosic biomass using microorganisms - At least one isolated microorganism, which converts at least 10% by weight, and preferably 50% by weight, of cellulosic biomass to a lower alkyl alcohol by direct digestion, and which produces at least 4% by volume of the lower alkyl alcohol in an aqueous-based digestion medium. | 2016-01-21 |
20160017379 | Process For Production Of Ethanol From Biomass - An object of the present invention is to provide a method for producing ethanol efficiently even in the presence of a fermentation inhibitor in a saccharified biomass. The present invention provides a method for producing ethanol from biomass, comprising: culturing a transformed xylose-utilizing yeast to overexpress the gene for at least one pentose phosphate pathway metabolic enzyme, with a saccharified biomass. | 2016-01-21 |
20160017380 | METHOD FOR PRODUCING ALCOHOLS AND/OR SOLVENTS FROM LIGNOCELLULOSIC BIOMASS WITH WASHING OF THE SOLID RESIDUE OBTAINED AFTER FERMENTATION - The process for the production of alcohol and/or solvent from a biomass feedstock comprises the stages for pretreatment (P) of the biomass feedstock, for enzymatic hydrolysis (H | 2016-01-21 |
20160017381 | BIOMASS CONVERSION TO FUELS AND CHEMICALS - This disclosure relates to compositions and methods for converting biomass to various chemical intermediates and final products including fuels. Aspects include the depolymerization of lignin, cellulose, and hemicellulose to a wide slate of depolymerization compounds that can be subsequently metabolized by genetically modified bacterium, and converted to cis,cis-muconic acid. Other aspects include the use of monometallic catalysts for converting the cis,cis-muconic acid to commodity chemicals and fuels, for example adipic acid and/or nylon. | 2016-01-21 |
20160017382 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE - A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms. | 2016-01-21 |
20160017383 | NOVEL ENGINEERED MICROORGANISM PRODUCING HOMO-SUCCINIC ACID AND METHOD FOR PREPARING SUCCINIC ACID USING THE SAME - The present invention relates to a mutant microorganism, which is selected from the group consisting of genus | 2016-01-21 |
20160017384 | FERMENTATION BASED ON HYDROLYZED CORN AND/OR SUGAR CANE MASH TO PRODUCE PROPIONIC ACID - A process to prepare propionic acid comprises preparing a fermentation broth of water; at least 30 weight percent hydrolyzed corn mash solids, hydrolyzed sugar cane mash solids, or a combination thereof, based on the combined weight of the fermentation broth as a whole; and | 2016-01-21 |
20160017385 | ENZYME-CATALYZED POLYOXYALKYLENE ESTERS - One aspect of the present invention is a polyoxyalkylene ester composition comprising the reaction product of a polyoxyalkylated alcohol or polyol reactant and an acyl donor wherein the ester has greater than about 85 weight percent of a fully acylated polyoxyalkylene ester, less than about 15 percent of a partially acylated polyoxyalkylene ester, less than about 5 parts per million 1,4-dioxane and an acid number of less than about 20. Another aspect of the invention is a process for making the polyoxyalkylene ester composition that includes the steps of contacting a reaction mixture of an polyoxyalkylated alcohol or polyol reactant and an acyl donor reactant in a reactor and in the presence of an enzymatic catalyst under esterification conditions and recovering the polyoxyalkylene ester. | 2016-01-21 |
20160017386 | ALTERING THE INTERFACE OF HYDROCARBON-COATED SURFACES - Methods and compositions are provided wherein microorganisms are used to alter the interface of hydrocarbons and hydrocarbon-coated surfaces to increase oil recovery, for improved bioremediation and/or to benefit pipeline maintenance. | 2016-01-21 |
20160017387 | GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING LONG-CHAIN DICARBOXYLIC ACID AND METHOD OF USING THEREOF - Described herein are genetically-modified microorganisms for producing long-chain dicarboxylic acids and methods of using the microorganisms. The microorganisms contain a first nucleic acid encoding an | 2016-01-21 |
20160017388 | PRODUCTION OF FATTY ACIDS BY HETEROLOGOUS EXPRESSION OF GENE CLUSTERS FROM MYXOBACTERIA - The invention relates to a process for producing one or more polyunsaturated fatty acids by means of heterologous gene expression comprising the steps of providing a production organism which comprises a heterologous gene cluster encoding a polyunsaturated fatty acid biosynthetic pathway encompassing a subsequence ER encoding an enoylreductase and a subsequence AT encoding an acyltransferase,
| 2016-01-21 |
20160017389 | METHOD FOR PREPARING (2RS)-AMINO-(3S)-HYDROXY-BUTYRIC ACID AND ITS DERIVATIVES - The present invention relates to a method for easily preparing (2RS)-amino-(3S)-hydroxy-butyric acid, which is a chiral amino acid, in a high yield and a high purity using a chemical synthesis and enzymatic reduction reaction; an intermediate therefor; and a method for preparing the intermediate. | 2016-01-21 |
20160017390 | FUCOSIDASE FROM BACTEROIDES AND METHODS USING THE SAME - The present disclosure relates to an α-fucosidase having α-(1,2), α-(1,3), α-(1,4), and α-(1,6) fucosidase activity. The present disclosure also relates to the compositions comprising the α-fucosidase, and the methods of producing and using the α-fucosidase in cleaving α-(1,2), α-(1,3), α-(1,4), and/or α-(1,6)-linked fucoses in the glycoconjugates. | 2016-01-21 |
20160017391 | cDNA Synthesis Improvements - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 2016-01-21 |
20160017392 | Methods for Amplification of Nucleic Acids on Solid Support - The present invention provides methods for amplifying a nucleic acid from a sample containing a mixture of nucleic acids utilizing a solid support. Methods are provided utilizing user-defined primer oligonucleotides for directional amplification that assists in further manipulation of the target nucleic acid, such as sequencing. Methods are also provided utilizing blocker and displacer oligonucleotides for generating amplified target nucleic acids of defined length. One of these methods provides a first oligonucleotide and a second oligonucleotide affixed to a solid support or separate solid supports. The first oligonucleotide is blocked to prevent extension from the 3′-terminus and has a sequence complementary to a first portion of a target nucleic acid. The second oligonucleotide has a sequence that is identical to a second portion of the target nucleic acid. In this method, a sample is applied to the solid support and the target nucleic acid within the sample binds said first oligonucleotide. The solid support is then washed to remove unbound nucleic acids. A primer sequence containing a target binding region and a polymerase promoter sequence is then annealed to the bound target nucleic acid and extended producing a first duplex nucleic acid. The target sequence is then removed leaving a first nucleic acid that can now bind the second oligonucleotide. The second oligonucleotide is extended to produce a second duplex nucleic acid that contains a second nucleic acid. The second nucleic acid is then amplified by adding a polymerase. | 2016-01-21 |
20160017393 | DIRECTED ENDONUCLEASES FOR REPEATABLE NUCLEIC ACID CLEAVAGE - The invention provides compositions and methods for repeatable directed endonucleases (RDEs) and methods for repeatedly, and specifically cleaving DNA offset from the RDE's DNA recognition sequence on the target nucleic acid rather than within the DNA recognition sequence. Conservation of the recognition sequence of the target nucleic acid enables for re-localization of an RDE back to the DNA recognition sequence for further cleavage. The RDEs and methods of the invention are useful in applications including, but not limited to, recording data into a genome, timing the order of biochemical pathway events, efficient genome engineering and encoding lagged cellular death. | 2016-01-21 |
20160017394 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID ASSEMBLY - The present disclosure generally relates to compositions and methods for the assembly of nucleic acid molecules into larger nucleic acid molecules. Also provided are compositions and methods for seamlessly connection of nucleic acid molecules with high sequence fidelity. | 2016-01-21 |
20160017395 | REAGENTS AND KIT COMPOSITIONS FOR SINGLE-CELL WHOLE GENOME AMPLIFICATION - The present invention provides reagents, kits, and methods for single-cell whole genome amplification using Phi 29 DNA polymerase. | 2016-01-21 |
20160017396 | POLYNUCLEOTIDE ENRICHMENT USING CRISPR-CAS SYSTEMS - A method for enriching a target nucleic acid comprising providing an endonuclease system having a crRNA or a derivative thereof, and a Cas protein or a variant thereof. The crRNA or the derivative thereof contains a target-specific nucleotide region substantially complementary to a region of the target nucleic acid; contacting the target nucleic acid with the endonuclease system to form a complex; and separating the complex and thereby enriching for the target nucleic acid. | 2016-01-21 |
20160017397 | MONITORING A DYNAMIC SYSTEM BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (LC) combined with mass spectrometry (MS). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system. | 2016-01-21 |
20160017398 | PROCESSES FOR BIOCONVERSION OF CARBON BEARING MATERIALS - A process involving a microorganism consortium for converting at least one component in a carbon-bearing material to a different product comprising at least one hydrocarbon. In the process, a microorganism consortium is contacted with a composition that causes an increase or decrease of a relative population of at least one species of microorganism in said microorganism consortium, to enhance a yield or selectivity or alter a rate of said process. The composition may be selected from a composition that affects an intracellular pathway of said at least one species of microorganism, a composition that affects an intercellular signaling pathway that involves said at least one species of microorganism and at least one antisense RNA. Also, the microorganism consortium can be exposed to signals such as sound waves or electromagnetic signals or a condition of the environment of the microorganism consortium can be altered. | 2016-01-21 |
20160017399 | ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH ENZYMATIC REAGENT LAYER CONTAINING A NAPHTHOQUINONE-BASED MEDIATOR AND FAD-GDH - An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator. The naphthoquinone-based mediator can, for example, be at least one of 1,2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and 1,2-naphthalenedione-4-(3-mercaptopropionic acid); and FAD-GDH enzyme. | 2016-01-21 |
20160017400 | Method for improved detection of microorganisms and the like - A method is provided of applying a test sample to a fibrous pad containing growth media which uses unaccelerated dispersion and deposition of the microorganism. | 2016-01-21 |
20160017401 | Method and apparatus for trapping and growing micro-organisms using pre-filter pads and similar pads - A method and apparatus for achieving optimum results of MF and/or Microtrap™ methods considering all of the basic elements that may be included in the MF and/or Microtrap™ apparatus with or without the need for a separate membrane filter and pad. In a major new addition to the classical MF and Microtrap™ approaches in the present invention, a different type of pad can be used to serve the function of both a pad and a membrane filter, (e.g. what is known in the industry as a “pre-filter”) through the use of fine mesh glass material for the pad, that material being non-toxic to the target micro-organisms (formed from fiberglass filaments, for example), with small openings (e.g. 0.3 to 0.7 micrometers). The pad may be pre-treated with growth media, preferably in dehydrated format, and formed of sufficient thickness to absorb and retain the sample fluid in which the target organisms are entrained. That fluid passing into the pad may, for example, function to activate the growth media so that it is available to the micro-organisms retained on the surface of the mesh. | 2016-01-21 |
20160017402 | Method and apparatus utilizing enzyme substrates producing slow diffusing fluorescent product appearances and chromogens, and use in combination with fast diffusing product appearances - A new method of rapid detection of cells, microorganisms, or other items is described using various combinations of indicator enzyme substrates which can be used to yield fluorophoric and chromophoric appearances due to enzymatic activity. One aspect of the invention is the use of a family of compounds that can be used to produce slow diffusing fluorophoric appearances. Another aspect is a family of compounds identified as dual enzyme substrates that can be used to produce both fluorophoric and chromogenic appearances. | 2016-01-21 |
20160017403 | QUANTIFICATION OF MISFOLDED TNFR2:FC - The present invention is directed to methods for determining the relative amount of wrongly disulphide bridged TNFR2:Fc in a sample of TNFR2:Fc, a fusion protein which is used in a variety of therapeutic applications. In addition, the invention pertains to a method for purifying TNFR2:Fc using said method for determining the percentage of wrongly disulphide bridged TNFR2:Fc, and to TNFR2:Fc compositions obtained thereby. | 2016-01-21 |
20160017404 | SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES - The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. | 2016-01-21 |
20160017405 | FAST HYBRIDIZATION FOR NEXT GENERATION SEQUENCING TARGET ENRICHMENT - The present invention relates to compositions and methods of target enrichment or selection of nucleic acids using hybridization, which can be used in, e.g., next-generation sequencing. | 2016-01-21 |
20160017406 | METHOD FOR DETECTING HELICOBACTER PYLORI DNA IN A STOOL SAMPLE - The present invention provides a PCR based method for detecting chronic gastritis causing bacterium, namely | 2016-01-21 |
20160017407 | Methods for Microorganism Detection and Identification - Methods for detecting and identifying microorganisms in a biologic sample are provided. The methods utilize identifying rRNA from microorganisms to both show the presence and identity for the majority of infectious agents present in clinical samples. The methods are preferably adapted for use in a clinical setting. | 2016-01-21 |
20160017408 | METHODS AND KITS TO DETERMINE THE SENSITIVITY OF STRAINS OF LACTOCOCCUS LACTIS BACTERIA TO PHAGE INFECTION - A kit useful for determining the phage susceptibility of one or more strains of | 2016-01-21 |
20160017409 | Compositions and Methods for Identifying Secretory Antibody-Bound Microbes - The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof. | 2016-01-21 |
20160017410 | HIGHLY MULTIPLEX SINGLE AMINO ACID MUTAGENESIS FOR MASSIVELY PARALLEL FUNCTIONAL ANALYSIS - Disclosed is a method for multiplexed mutagenesis of a target nucleotide sequence. The method entails generating, in parallel, a set of mutagenic oligonucleotide primers designed to cover all or part of the target nucleotide sequence, and reacting the set of mutagenic oligonucleotide primers with the target sequence in the presence of a polymerase to generate a mutant nucleotide sequence library, wherein each member of the mutant nucleotide sequence library comprises a full-length copy of the target nucleotide sequence having a unique programmed mutation derived from one member of the set of mutagenic oligonucleotide primers. Also disclosed are methods for generating a mutant nucleotide sequence library and for generating a mutant protein library. | 2016-01-21 |
20160017411 | ASSAY FOR DETECTING A NUCLEIC ACID ANALYTE IN A BIOLOGICAL SAMPLE - An assay for detecting an analyte in a biological sample. The assay comprises a surface probe linked to the surface of a measuring electrode and the surface probe has a nucleic acid sequence complementary to a first target nucleic acid sequence. The assay also comprises a signal probe, having a nucleic acid sequence complementary to a second target nucleic acid sequence and a binding element capable of binding a ligand. The ligand is associated with a catalytic element or precursor thereof capable of reacting with a substrate to alter electrical potential of the measuring electrode. | 2016-01-21 |
20160017412 | NON-INVASIVE PRENATAL DIAGNOSIS OF FETAL GENETIC CONDITION USING CELLULAR DNA AND CELL FREE DNA - Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of maternal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly. | 2016-01-21 |
20160017413 | ENZYMES RESISTANT TO PHOTODAMAGE - Provided are compositions comprising modified DNA polymerases that exhibit improved photostability compared to the parental polymerases from which they were derived. Provided are methods for generating enzymes, such as DNA polymerases, with the aforementioned phenotype. Provided are methods of using polymerases with increased resistance to photodamage to make a DNA or to sequence a DNA template. | 2016-01-21 |
20160017414 | Single Molecule Arrays for Genetic and Chemical Analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 2016-01-21 |
20160017415 | METHODS AND KITS FOR IDENTIFYING AND ADJUSTING FOR BIAS IN SEQUENCING OF POLYNUCLEOTIDE SAMPLES - Disclosed are methods for determining one or more nucleotides at one or more nucleotide positions of a polynucleotide sample, the polynucleotide sample comprising heterogeneous polynucleotides having different nucleotides at the nucleotide positions. The disclosed, methods may be utilized to control for sequencing bias during sequencing of the polynucleotide sample. Suitable samples may include patient samples for use in diagnosing, prognosing, and treating the patient. | 2016-01-21 |
20160017416 | BIOCHEMICALLY ACTIVATED ELECTRONIC DEVICE - A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid. | 2016-01-21 |
20160017417 | METHODS AND SYSTEMS FOR GENETIC ANALYSIS - This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions. | 2016-01-21 |
20160017418 | METHOD OF DETECTING METHYLATION - The present invention relates to a method of screening for the presence of methylated DNA in a biological sample by using multiple methylation-sensitive restriction endonucleases. More particularly, the present invention relates to a method of quantitatively screening for the level of one or more methylated genes of interest without the requirement that an undigested internal reference sample is used as a point of reference against which relative quantification is calculated. The present invention is useful in a range of applications including, but not limited to, providing a simpler and more accurate means to determine DNA methylation status, such as in the context of diagnosing or monitoring conditions characterised by changes to DNA methylation. | 2016-01-21 |
20160017419 | METHYLATION PATTERN ANALYSIS OF TISSUES IN A DNA MIXTURE - The contributions of different tissues to a DNA mixture are determined using methylation levels at particular genomic sites. Tissue-specific methylation levels of M tissue types can be used to deconvolve mixture methylation levels measured in the DNA mixture, to determine fraction contributions of each of the M tissue types. Various types of genomic sites can be chosen to have particular properties across tissue types and across individuals, so as to provide increased accuracy in determining contributions of the various tissue types. The fractional contributions can be used to detect abnormal contributions of a particular tissue, indicating a disease state for the tissue. A differential in fractional contributions for different sizes of DNA fragments can also be used to identify a diseased state of a particular tissue. A sequence imbalance for a particular chromosomal region can be detected in a particular tissue, e.g., identifying a location of a tumor. | 2016-01-21 |
20160017420 | METHODS FOR PROFILING AND QUANTITATING CELL-FREE RNA - The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected. | 2016-01-21 |
20160017421 | NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF HLA GENE AMPLICONS - The invention is a method of detecting or assessing solid organ graft (transplant) rejection and acute dysfunction—no rejection condition by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. | 2016-01-21 |
20160017422 | MARKER GENES FOR OOCYTE COMPETENCE - Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the bio-marker genes identified using the methods of the present invention. | 2016-01-21 |
20160017423 | METHOD AND KIT FOR MAKING AN IN VITRO PROGNOSIS OF SEVERITY FOR A PATIENT IN SEPTIC SHOCK - The subject of the invention is a method for making an in vitro prognosis of severity for a patient in septic shock, including the following steps: (i) the level of expression of the expression product of at least one gene chosen from the lilrb2 and lilrb1 genes is measured in vitro on the basis of a biological sample taken from the patient, (ii) the level of expression of the expression product of the at least one gene is compared with a control level of expression, of the expression product of the same gene, with a good prognosis of severity, in which a level of expression of the expression product of the at least one gene below the control level of expression indicates a poor prognosis of severity for the patient, and also a kit for implementing the method. | 2016-01-21 |
20160017424 | COLLECTION OF PROBES FOR AUTISTIC SPECTRUM DISORDERS AND THEIR USE - The present invention relates to collections of probes or their complements that recognize a set of biomarkers related to autism spectrum disorders (ASDs), as well as to methods utilizing these probes for diagnosing whether a subject has an ASD or has a predisposition for developing an ASD. | 2016-01-21 |
20160017425 | Detection of Genomic Rearrangements by Sequence Capture - Provided herein is a method of sample analysis. In some embodiments, the method comprises hybridizing fragmented genomic DNA from a test genome with a population of first oligonucleotides of the formula V | 2016-01-21 |
20160017426 | METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND RELATED PATHOLOGIES - Methods for assessing infertility and related pathologies and informing treatment type and timing thereof are provided. According to certain embodiments, methods of the invention include determining levels of one or more transcripts present in a sample obtained from a subject suspected of having endometriosis, identifying transcript levels that correspond to a regulation pattern specific to a time-point in a uterine cycle, and characterizing endometriosis of the subject based upon the identified transcript levels. The invention includes methods for assessing age-associated increase in aneuploidy rates based on FSH levels and IVF success rates based on obesity in PCOS patients. | 2016-01-21 |
20160017427 | TREATING FEMALE PELVIC ORGAN PROLAPSE - Provided are methods for diagnosing an increased risk of failure in a female pelvic organ prolapse surgery. Also provided are devices and kits for detection of a SNP associated with increased risk of failure in a female pelvic organ prolapse surgery. | 2016-01-21 |
20160017428 | Recombination Sequence (RS) Rearrangement Frequency as a Measure of Central B Cell Tolerance - The invention relates to methods and materials for diagnosing an autoimmune disease such as SLE, Type 1 diabetes, and the like. More particularly, the invention relates to methods and materials for assessing the frequency of recombination sequence (RS) rearrangement as a novel marker for an autoimmune disease. Such an assay can allow clinicians to diagnose an autoimmune disease based on the RS rearrangement frequency in an autoimmune patient as compared to an otherwise healthy control. In addition, the method includes identifying individuals who are at increased risk of developing autoimmunity. The method may also be helpful in directing the type of therapy and monitoring the effects of therapy in patients with autoimmune or non-autoimmune conditions. | 2016-01-21 |
20160017429 | METHOD FOR PROGNOSING THE SURVIVAL OF PATIENTS SUFFERING FROM CHRONIC MYELOMONOCYTIC LEUKAEMIA - The present invention relates to a method of prognostic of the survival of human subject suffering from chronic myelomonocytic leukemia (CMML) based on the differential expression of six genes in a test sample of PBMC cells obtained from said human subject and in a control sample of normal cells, wherein said expression level indicates if the human subject from which the test sample has been obtained will have long-term or short-term survival. | 2016-01-21 |
20160017430 | METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGIN BY METHYLATION ANALYSIS - The invention relates to methods and reagents for the identification of the origin of a carcinoma of unknown primary origin (CUP) based on the determination of the methylation profile in the genome of the CUP. The invention relates as well to methods for selecting a suitable therapy for a patient suffering a CUP as well as to methods for personalized medicine of patient suffering a CUP based on the use of a treatment which is adequate for the primary tumor from which the CUP is derived. The invention also relates to kits comprising reagents adequate for performing the above methods as well as to computer systems and programs which can be used for implementing the methods of the invention. | 2016-01-21 |
20160017431 | Methods for Predicting EGFR Tyrosine Kinase Inhibitor Efficacy - Provided herein are compositions and methods for predicting whether a subject with cancer will be responsive to treatment with an EGFR TKI and for the treatment of cancer in a subject. | 2016-01-21 |
20160017432 | PHARMACEUTICAL COMPOSITION FOR TREATING MUSCLE-INVASIVE BLADDER CANCER, CONTAINING S100A9 AND EGFR INHIBITORS AND CISPLATIN AS ACTIVE INGREDIENTS - The present invention relates to a method for predicting the probability of muscle-invasive bladder cancer (MIBC) recurrence or metastasis, a method for providing information on a personalized medicine of MIBC, and a pharmaceutical composition for treating MIBC, containing S100A9 and EGFR inhibitors and cisplatin as active ingredients. According to the present invention, it is possible to accurately predict a prognosis after chemotherapy of an MIBC patient, to provide information on cisplatin sensitivity in the provision of a personalized medicine for chemotherapy of an MIBC patient, and to increase the cisplatin sensitivity of an MIBC patient by concomitantly administering S100A9 and EGFR inhibitors together with a conventional cisplatin. | 2016-01-21 |
20160017433 | NON-INVASIVE DIAGNOSTIC METHOD FOR DIAGNOSING BLADDER CANCER - Non-invasive diagnostic methods for diagnosing bladder cancer are based on determining the expression level of one or more markers. The one of the markers comprises the IGF2 gene in a sample from the subject to be studied. Other suitable markers include MAGEA3, ANXAIO, AHNAK2, CTSE, CRH, KLF9, KRT20, POSTN, PPP1R14D, SLCIA6, TERT, ASAM, MCMIO, EBF1, CFH and MMP12 and possibly FOXM1, KIF20A, MELK, CDK1. | 2016-01-21 |
20160017434 | MOLECULAR MARKERS IN BLADDER CANCER - The Present invention relates methods for establishing the presence, or absence, of a bladder tumour and/or classification of the tumor according to the aggressiveness and/or establishing the prediction of prognosis and disease outcome for a human individual suffering from bladder cancer. Specifically, the present invention relates to methods for establishing the presence, or absence, of a bladder tumour in a human individual comprising: determining the expression of one or more genes chosen from the group consisting of ADAMTS12, ASPN, CDC20, COL10A1, CTHRC1, FAP, SFRP4, FOXM1, KRT6A, ANLN, CHI3L1, TPX2, CCNB2, IGF2BP2, INHBA, PDCD1LG2, transcript cluster 2526893, and transcript cluster 2526896 in a biological sample (tissue or bodyfluid) originating from said human individual; establishing up regulation of expression of said one or more genes as compared to expression of said respective one or more genes in a sample originating from said human individual not comprising tumour cells or tissue. | 2016-01-21 |
20160017435 | Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer - The present disclosure provides for and relates to the identification of novel biomarkers for diagnosis and prognosis of prostate cancer or the biochemical reoccurence of prostate cancer. The biomarkers of the invention show altered methylation levels of certain CpG loci relative to normal prostate tissue, as set forth. | 2016-01-21 |
20160017436 | ARTIFICIAL SYNTHETIC CDNA AND METHOD FOR DETECTING SECONDARY GLIOBLASTOMA - The present invention provides an artificial synthetic cDNA (complementary deoxyribonucleic acid). The said artificial synthetic cDNA encodes a fused protein which is specifically presented in secondary glioblastoma, and the said artificial synthetic cDNA can be used as a biomarker for detecting the secondary glioblastoma. The present invention further provides a method for detecting secondary glioblastoma. According to the above technical solutions, the accuracy in distinguishing the secondary glioblastoma from primary glioblastoma is effectively improved in the present invention. | 2016-01-21 |
20160017437 | MIR-193A-3P AND ASSOCIATED GENES PREDICT TUMORIGENESIS AND CHEMOTHERAPY OUTCOMES - The disclosure provides a correlation between the expression level of the miR-193a gene, which can be regulated by its methylation status, and both tumorigenesis of and the resistance of a cancer cell to a pyrimidine antimetabolite (5-FU) based chemotherapy. In addition to the methylation status and the expression of miR-193a, its downstream genes, such as E2F1, SRSF2, and apoptotic genes such as caspase 2, are also involved and can serve as useful markers for cancer therapy prognosis and for therapy selection. | 2016-01-21 |
20160017438 | METHODS OF TREATING BREAST CANCER WITH TAXANE THERAPY - The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective. | 2016-01-21 |
20160017439 | MARKER OF BREAST TUMORS FROM THE LUMINAL-B SUBTYPE - An in vitro method for diagnosing a breast cancer from the luminal-B subtype in a female, includes the steps of analyzing a biological sample from the female by (i) determining the copies number of the ZNF703 gene, and/or (ii) determining the expression of the ZNF703 gene, wherein an increased copies number and/or an over-expression of the ZNF703 gene is indicative of a luminal B tumor; to a kit for diagnosing a breast cancer from the luminal-B subtype in a female including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a method as defined previously, for determining the copies number of the ZNF703 gene, and/or determining the expression of the ZNF703 gene; and to the use of such a kit. | 2016-01-21 |
20160017440 | Methods Of Classifying Biological Samples For Predicting Response To Tyrosine Kinase Inhibitor Treatment - Gene copy numbers of signaling components downstream of EGFR identify non-small cell lung cancer (NSCLC) patients with poor outcomes on 2nd/3rd line gefitinib therapy. | 2016-01-21 |
20160017441 | METHOD FOR IDENTIFYING CELLS - It is an object of the present invention to provide a method for analyzing, in detail, the epigenetic state of stem cells. | 2016-01-21 |
20160017442 | Multiplex Real Time PCR Testing Kit for the Simultaneous Detection of Hepatitis Virus - Provided herein are primers and probes for the detection of Hepatitis B virus and Hepatitis C virus in a sample, a reaction mixture for multiplex real time PCR for the simultaneous detection and quantitation of Hepatitis B and C and a test kit based on multiplex real time PCR for the simultaneous detection and quantitation of Hepatitis B and C. | 2016-01-21 |
20160017443 | CRUDE JUICE PURIFICATION WITH REDUCED LIME CONSUMPTION - The present invention relates to an improved method for the purification of crude sugar beet juice. The present invention relates moreover to methods for the manufacture of non-sucrose substance combinations from crude sugar beet juice, as well as two devices for the purification of crude sugar beet juice. The measures according to the invention allow a reduction of lime consumption during the purification. | 2016-01-21 |
20160017444 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can be useful in enhancing sugar yields from biomass. | 2016-01-21 |
20160017445 | METHODS AND SYSTEMS FOR PRODUCING DIRECT REDUCED IRON AND STEEL MILL FUEL GAS USING COKE OVEN GAS AND BASIC OXYGEN FURNACE GAS - A process for producing reducing gas for use in the production of direct reduced iron (DRI) and fuel gas for use in a steel mill, comprising: compressing a coke oven gas (COG) stream in a compressor; passing the compressed coke oven gas stream through an activated charcoal bed to remove tars from the compressed coke oven gas stream; separating a hydrogen-rich gas stream from the compressed cleaned coke oven gas stream using a pressure swing absorption unit; providing the hydrogen-rich gas stream to a direct reduction shaft furnace as reducing gas; and providing a remaining gas stream from the pressure swing absorption unit to a steel mill as fuel gas. Both once-through and recycle options are presented. Optionally, basic oxygen furnace gas (BOFG) is added to the reducing gas. Optionally, top gas from the direct reduction shaft furnace is cooled, cleaned, and recycled back to the reducing gas stream. In some cases, carbon dioxide is also removed from the top gas stream. | 2016-01-21 |
20160017446 | COKELESS REVERBERATORY FURNACE FOR MELTING IRON WITH SEPARATE HEARTH AND MELTING CHAMBER - The invention relates to a process of melting metal using a gaseous fuel, a liquid fuel or a pulverized solid fuel in a reverberatory furnace (FIG. | 2016-01-21 |
20160017447 | METHODS AND SYSTEMS FOR PRODUCING DIRECT REDUCED IRON UTILIZING A PETROLEUM REFINERY BOTTOMS OR PETROLEUM COKE GASIFIER AND A HOT GAS CLEANER - Methods and systems for producing DRI utilizing a petroleum refinery bottoms (i.e. heavy fuel oil, vacuum residue, visbreaker tar, asphalt, etc.) or petroleum coke gasifier and a hot gas cleaner. Cooling of the hot synthesis gas generated by the petroleum refinery bottoms or petroleum coke gasifier to <200 C is not necessary. Rather, the synthesis gas from the petroleum refinery bottoms or petroleum coke gasifier is desulfurized and dedusted at high temperature (>350 C) using a hot gas cleaner, well known to those of ordinary skill in the art, although not in such an application. This hot gas cleaner may be high pressure or low pressure. | 2016-01-21 |
20160017448 | SOFT MAGNETIC COMPONENT STEEL MATERIAL HAVING EXCELLENT PICKLING PROPERTIES, SOFT MAGNETIC COMPONENT HAVING EXCELLENT CORROSION RESISTANCE AND MAGNETIC PROPERTIES, AND PRODUCTION METHOD THEREFOR - Provided is a steel material for soft magnetic components, having excellent pickling properties and capable of achieving excellent magnetic properties and corrosion resistance in a final component. The steel material for soft magnetic components comprises, in % by mass, 0.001%-0.025% C, more than 0% but less than 1.0% Si, 0.1%-1.0% Mn, more than 0% but no more than 0.030% P, more than 0% but no more than 0.08% S, more than 0% but less than 0.5% Cr, more than 0% but no more than 0.010% Al, and more than 0% but no more than 0.01% N, with the remainder being iron and unavoidable impurities; and is characterized by having a rolled scale including 40-80 vol % FeO being formed on the steel material surface. | 2016-01-21 |
20160017449 | 700MPA-Level High-Strength Hot Rolling Q&P Steel And Method Of Manufacturing The Same - A 700 Mpa-level high-strength hot rolling Q&P steel and the method of manufacturing the same, which steel has the chemical compositions in weight percentage as follows: C: 0.15%˜0.40%; Si: 1.0%˜2.0%; Mn: 1.5%˜3.0%; P: less than or equal to 0.015%; S: less than or equal to 0.005%; Al: 0.3%˜1.0%; N: less than or equal to 0.006%; Ti: 0.005%˜0.015%, the remainders being Fe; it having a yield strength of more than or equal to 700 Mpa, a tensile strength of more than or equal to 1300 Mpa and an elongation rate of more than 10%. Through reasonable design on the compositions and on the basis of the compositions of common C—Mn steel, the present invention improves the content of Si to restrict the precipitation of cementite, performs the micro-Ti treatment to refine the austenite grains, and improves the content of Al to quicken the austenite transformation dynamics during the air cooling process; at the same time, combines the hot rolling process with the staged cooling process to obtain the structures of proeutectoid ferrite plus martensite plus retained austenite and reduces the cost of alloy elements substantially. | 2016-01-21 |
20160017450 | LOCALIZED HARDENING OF METALLIC SURFACES - The present invention relates to a method and system for treatment of a surface of a metallic material component, the method comprising the steps: electro-spark treating the surface of the metallic component by means of an electro-spark electrode, wherein the metallic material is a basically ferritic, perlitic and/or austenitic steel and the method creates a thin layer with martensitic microstructures at the surface of the metallic material component. Serpentines and quartz can be incorporated by an additional step as well as the surface randomly structured by this. | 2016-01-21 |
20160017451 | FERRITIC STAINLESS STEEL SHEET EXHIBITING SMALL INCREASE IN STRENGTH AFTER AGING HEAT TREATMENT, AND METHOD OF PRODUCING THE SAME - A ferritic stainless steel sheet exhibiting small increase in strength after aging heat treatment in the present invention contains, by mass %, C: 0.020% or less, Cr: 10.0% to 25.0%, N: 0.020% or less, Sn: 0.010% to 0.50%, and one or more of Ti: 0.60% or less, Nb: 0.60% or less, V: 0.60% or less, and Zr: 0.60% or less so as to satisfy the following Equation (1), in which the difference between stress σ1 (N/mm | 2016-01-21 |
20160017452 | PROCESS FOR MANUFACTURING PRESS-HARDENED COATED STEEL PARTS AND PRECOATED SHEETS ALLOWING THESE PARTS TO BE MANUFACTURED - This invention relates to a cold-rolled sheet that is annealed and pre-coated for the fabrication of press hardened parts, composed of a steel substrate for heat treatment with a carbon content C | 2016-01-21 |
20160017453 | METHOD FOR PRODUCING A MOTOR VEHICLE COMPONENT, AND A BODY COMPONENT - A method for producing a structural and/or safety-related motor vehicle component having at least one hot-formed and press-hardened part constructed from high-strength steel includes the steps of partially heat-treating a region of the motor vehicle component by heating the region to a heat-up temperature in a temperature range between 500° C. and 900° C.; maintaining the heat-up temperature for a duration of a holding time; and cooling down from the heat-up temperature in one or more phases. A body component constructed as a structural and/or safety-related motor vehicle component from a steel sheet blank that has been hot-formed and press-hardened includes joining flanges and/or coupling locations and/or safety-related parts, wherein the joining flanges, coupling locations and/or safety-related parts are partially heat-treated in several steps with the disclosed method. | 2016-01-21 |
20160017454 | HARDFACING PROCESS AND PARTS PRODUCED THEREBY - A hardfacing process includes depositing a clad layer having a thickness greater than about 1 mm (0.04 in) on a surface of the component by arc welding, and creating a heat affected zone directly below the clad layer due to the depositing. The heat affected zone may be a region of the component where a lowest hardness is more than 40% lower than a base hardness of the component below the heat affected zone. The method may also include heat treating the component after the deposition such that the lowest hardness in the heat affected zone is restored to within about 15% of the base hardness of the component. | 2016-01-21 |
20160017455 | METHOD OF MAKING A DUAL HARDNESS STEEL ARTICLE - A dual hardness steel article comprises a first air hardenable steel alloy having a first hardness metallurgically bonded to a second air hardenable steel alloy having a second hardness. A method of manufacturing a dual hard steel article comprises providing a first air hardenable steel alloy part comprising a first mating surface and having a first part hardness, and providing a second air hardenable steel alloy part comprising a second mating surface and having a second part hardness. The first air hardenable steel alloy part is metallurgically secured to the second air hardenable steel alloy part to form a metallurgically secured assembly, and the metallurgically secured assembly is hot rolled to provide a metallurgical bond between the first mating surface and the second mating surface. | 2016-01-21 |
20160017456 | THICK STEEL SHEET HAVING EXCELLENT CTOD PROPERTIES IN MULTILAYER WELDED JOINTS, AND MANUFACTURING METHOD FOR THICK STEEL SHEET - There is provided a thick steel plate having good multipass weld joint CTOD characteristics for low to medium heat input and a method for manufacturing the thick steel plate. A steel plate containing, on a mass percent basis, C: 0.03% to 0.12%, Si: 0.5% or less, Mn: 1.0% to 2.0%, P: 0.015% or less, S: 0.0005% to 0.0050%, Al: 0.005% to 0.060%, Ni: 0.5% to 2.0%, Ti: 0.005% to 0.030%, N: 0.0015% to 0.0065%, O: 0.0010% to 0.0050%, Ca: 0.0005% to 0.0060%, and optionally one or two or more of Cu and the like, wherein Ti/N, Ceq, Pcm, and ACR are in particular ranges, a base material of the plate has an effective grain size of 20 μm or less at half the thickness of the plate, and the plate contains a particular number of complex inclusions at ¼ and ½ of the thickness of the plate, the complex inclusions being composed of a sulfide containing Ca and Mn and an oxide containing Al and having an equivalent circular diameter of 0.1 μm or more. Steel having the composition described above is heated at a particular temperature, is then hot-rolled, and is cooled. | 2016-01-21 |
20160017457 | METHOD FOR TREATING SHEET METAL - A method for treating sheet metal is disclosed. An amorphous mass containing an alloying element is applied onto a first area of a surface of the metal sheet. A second area of the surface is kept free of the amorphous mass. The amorphous mass and at least the first area of the metal sheet are heated in order to alloy the alloying element into the first area of the metal sheet while the second area remains unalloyed. | 2016-01-21 |
20160017458 | Direct Smelting Process and Apparatus - A process and apparatus for direct smelting metalliferous material is disclosed. The invention concentrates injection of solid feed materials comprising metalliferous material and carbonaceous material into a direct smelting vessel during the course of the process into a relatively small region within a metal layer in a molten bath in the vessel in order to generate a substantial upward movement of molten material and gas from the metal layer into a region in the vessel that is above the molten bath. In particular, the invention injects the solid food materials with sufficient momentum and/or velocity via an opposed pair of lances that are oriented within the vessel and arranged to form overlapping plumes of injected material in the molten bath. | 2016-01-21 |
20160017459 | SYSTEMS AND METHODS FOR SEPARATING AND RECOVERING RARE EARTHS - The present application is generally directed to separation and recovery of rare earths using biomass, liposomes, and/or other materials. In some embodiments, a composition comprising rare earths is exposed to biomass, where some of the rare earths are transferred to the biomass, e.g., via absorption. The composition may then be separated from the biomass. A solution may be exposed to the biomass, such that some of the rare earths are released from the biomass into the solution, thereby enriching the solution in one or more rare earths, relative to other rare earths in the biomass. The solution and the biomass may then be separated, and the rare earths recovered from the solution. In some cases, this process may be repeated with different solutions, e.g., having differences in pH or ionic concentration, which may result in different solutions enriched in various rare earths. In addition, in some embodiments, similar processes may be used to separate the rare earths from thorium and uranium. Also, in some embodiments, liposomes may be used instead of and/or in addition to biomass. | 2016-01-21 |
20160017460 | FREEFALL FORMING OF BULK METALLIC GLASS FEEDSTOCK AND SHEET MATERIAL - The disclosure is directed to freefall methods and apparatuses for preparation of amorphous BMG feedstock and sheet material. In certain aspects, the disclosure relates to methods and apparatuses for contactless formation of BMG feedstock and sheet material via a drop-tower. In certain embodiments, the methods comprise releasing droplets of molten amorphous alloy into a cooled, pressurized chamber of a drop-tower, wherein the droplets traverse the chamber through freefall to thereby form BMG feedstock or sheet material. | 2016-01-21 |
20160017461 | RADIOLUCENT MOLYBDENUM-CONTAINING MASTER ALLOYS - The present invention relates to a method for producing a Mo-containing master alloy that is radiolucent. In accordance with the present invention, two elements may be used to reduce the density of a Mo-containing master alloy enough to make the master alloy radiolucent, aluminum or titanium. Aluminum is required in the particular titanium alloy in the same weight ratio as Mo and cannot be used to decrease the master alloy density without skewing the ratio. Since the master alloy is being added to a titanium melt, much more titanium can be used to reduce the master alloy density. | 2016-01-21 |
20160017462 | MULTICALORIC MnNiSi ALLOYS - A multicaloric alloy material combines two isostructural compounds, the first compound being MnNiSi and the second compound being either MnFeGe or CoFeGe, each such compound having extremely different magnetic and thermo-structural properties. The resulting alloy material (MnNiSi) | 2016-01-21 |
20160017463 | HARD WELD OVERLAYS RESISTANT TO RE-HEAT CRACKING - Disclosed herein are embodiments of a hard weld overlay which can be resistant to cracking. The alloys can be able to resist cracking through prevention of the precipitation and/or growth of embrittling carbide, borides, or borocarbides along the grain boundaries at elevated temperatures. By controlling the thermodynamics of the boride and carbide phases, it is possible to create an alloy which forms hard wear resistant phases that are not present along the grain boundaries of the matrix. | 2016-01-21 |
20160017464 | CORROSION RESISTANT ARTICLE AND METHODS OF MAKING - An article and method of forming the article are disclosed. The article has a surface comprising a nanostructured ferritic alloy. The surface includes a plurality of nanofeatures that include complex oxides of yttrium and titanium disposed in an iron-bearing alloy matrix. The iron-bearing alloy matrix at the surface includes about 5 weight percent to about 30 weight percent of chromium, and about 0.1 weight percent to about 10 weight percent of molybdenum. Further, a concentration of a chi phase or a sigma phase in the nanostructured ferritic alloy at the surface is less than about 5 volume percent. The method generally includes the steps of milling, thermo-mechanically consolidating, annealing, and then cooling at a rate that hinders the formation of chi and sigma phases in the nanostructured ferritic alloy at the surface. | 2016-01-21 |
20160017465 | HOT-ROLLED STEEL SHEET - A hot-rolled steel sheet includes a specified chemical composition and includes a steel structure represented by an area ratio of ferrite being 5% to 50%, an area ratio of bainite composed of an aggregate of bainitic ferrite whose grain average misorientation is 0.4° to 3° being 50% to 90%, and a total area ratio of martensite, pearlite, and retained austenite being 5% or less. | 2016-01-21 |
20160017466 | HOT-ROLLED STEEL SHEET AND METHOD FOR PRODUCING THE SAME (AS AMENDED) - A hot-rolled steel sheet is provided having high strength and excellent toughness and ductility includes a composition that contains, on a mass percent basis, 0.04% or more and 0.15% or less of C, 0.01% or more and 0.55% or less of Si, 1.0% or more and 3.0% or less of Mn, 0.03% or less P, 0.01% or less S, 0.003% or more and 0.1% or less of Al, 0.006% or less N, 0.035% or more and 0.1% or less Nb, 0.001% or more and 0.1% or less of V, 0.001% or more and 0.1% or less Ti, and the balance being Fe and incidental impurities, in which the hot-rolled steel sheet includes a microstructure in which the proportion of precipitated Nb to the total amount of Nb is 35% or more and 80% or less, the volume fraction of tempered martensite and/or tempered bainite having a lath interval of 0.2 μm or more and 1.6 μm or less is 95% or more at a position 1.0 mm from a surface of the sheet in the thickness direction, and the volume fraction of ferrite having a lath interval of 0.2 μm or more and 1.6 μm or less at the center position of the sheet in the thickness direction is 95% or more. | 2016-01-21 |
20160017467 | Cold-Rolled Flat Steel Product for Deep Drawing Applications and Method for Production Thereof - A cold-rolled flat steel product for deep drawing applications is disclosed, composed of a steel which, in addition to Fe and unavoidable impurities (in % by weight) contains C: 0.008%-0.1%, Al: 6.5%-12%, Nb: 0.1%-0.2%, Ti: 0.15-0.5%, P: <0.1%, S: <0.03%, N: <0.1% and optionally one or more elements from the group of “Mn, Si, REM, Mo, Cr, Zr, V, W, Co, Ni, B, Cu, Ca, N”, provided that Mn: <1%, REM: <0.2%, Si: <2%, Zr: <1%, V: <1%, W: <1%, Mo: <1%, Cr: <3%, Co: <1%, Ni: <2%, B: <0.1%, Cu: <3%, Ca: <0.015%. The ratio is 2.5 ≧% Ti/% Nb ≧1.5, %Ti=Ti content and % Nb=Nb content. For production of such a flat steel product, a steel of appropriate composition is cast to give a pre-product, which is then hot-rolled to hot strip at a hot rolling end temperature of 820-1000° C. The latter is subsequently wound at a winding temperature of up to 750° C., after winding annealed at an annealing temperature of >650-1200° C. for 1-50 h, then cold-rolled in one or more stages with a total cold rolling level of ≧65% to give the cold-rolled flat steel product and finally annealed at 650-850° C. | 2016-01-21 |
20160017468 | Structural Steel For Through-Surface Hardening - The invention refers to development of chemical composition of perlite-class structural steels hardened by thermal treatment—through-surface hardening (TSH). The technical result is to obtain low and specified hardenability 3rd generation LH (SH) steels with a finer austenite grain ##11-13 GOST5639 (ASTM), even more stable preset hardenability (DI) with a substantially smaller To obtain a finer austenite grain and more stable hardenability—DI, with a substantially smaller deviation range and hardened layer depth directly obtained on parts subjected to TSH, as well as the possibility of machining thinner, smaller and other parts with the through-surface and through-thickness hardening. To achieve the technical result, structural steel was proposed for through-surface hardening with the following components ratio, weight %: carbon—0.15-1.2; manganese—not more than 1.8; silicon—not more than 1.8; chrome—not more than 1.8; nickel—not more than 1.8; molybdenum—not more than 0.5; tungsten—not more than 1.5; boron—not more than 0.007; copper—not more than 0.3; aluminum—0.03-0.1; nitrogen—not more than 0.1; titanium—not more than 0.4; vanadium,—not more than 0.4; zirconium—not more than 0.4; niobium—not more than 0.1; tantalum—not more than 0.1; calcium—not more than 0.03; sulphur—not more than 0.035; phosphorus—not more than 0.035; iron and unavoidable admixtures—rem., with ideal diameter determined by the following mathematical formula: | 2016-01-21 |