03rd week of 2010 patent applcation highlights part 52 |
Patent application number | Title | Published |
20100016588 | CAFFEINE FRACTION OBTAINED FROM TEA LEAVES AND A METHOD FOR INDUCING AGROBACTERIUM TUMEFACIENS-MEDIATED GENETIC TRANSFORMATION IN PLANTS USING SAID CAFFEINE FRACTION - The present invention relates to a thermolabile caffeine fraction useful for an efficient | 2010-01-21 |
20100016589 | Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof - The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R′=alkyl-2-methoxyphenyl piperazine (or) benzyl, R=2 methoxy phenyl, piperazine, 2-pyridyl piperazine, 2-pyrimidyl piperazine, 4-quinazolinyl piperazine, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl}carbonyl)hexahydro-1-pyrazinyl], and [(4[2 amino-4-(benzyloxy)-5-methoxybenzoyl]aminophenyl)sulfonyl]-4-benzamine; X═H (or) pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent. | 2010-01-21 |
20100016590 | NILOTINIB INTERMEDIATES AND PREPARATION THEREOF - Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl-5-(4-methyl-1H-imidazole-1-yl)-benzeneamine; 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino) -4-methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib.3HCl and its crystalline forms are also described. | 2010-01-21 |
20100016591 | SYNTHESIS OF 4-AMINO-PYRIMIDINES SCAFFOLDS - Process for the manufacture of a compound of the structure (I) with R | 2010-01-21 |
20100016592 | PROCESS FOR PREPARING SODIUM RISEDRONATE HEMIPENTAHYDRATE - A novel process for preparing risedronate sodium hemipentahydrate represented by the following formula 1 using 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid (risedronic acid) and an aqueous solution of risedronate sodium is disclosed. | 2010-01-21 |
20100016593 | CRYSTALLINE FORMS OF PALONOSETRON HYDROCHLORIDE - The present invention provides crystalline forms of Palonosetron hydrochloride, processes for their preparation and pharmaceutical compositions containing such crystalline forms of Palonosetron HCl. | 2010-01-21 |
20100016594 | PROCESS FOR THE PREPARATION OF CLOPIDOGREL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention provides a process for the preparation of clopidogrel and its pharmaceutically acceptable salts thereof comprises the resolving racemic methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate by the salt formation of methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate with excess levorotatory camphor-10-sulfonic acid to get a maximum yield of camphor sulphonate salt of methyl S-(+)-alpha-5-(4,5,6,7-tetrahydro[3,2-e]thienopyridyl)(2-chlorophenyl)-acetate and transforming the camphor sulphonate salt to clopidogrel or its pharmaceutically acceptable salts thereof. | 2010-01-21 |
20100016595 | PROCESS FOR PREPARING (S)-(+)-CLOPIDOGREL BASE AND ITS SALTS - Processes for the preparation of Methyl (+)-(S)-(2-chlorophenyl)-(6,7dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate [Clopidogrel base, (I)] and their various pharmaceutically acceptable salts. | 2010-01-21 |
20100016596 | PROCESS FOR THE PURIFICATION OF NEUROMUSCULAR BLOCKING AGENTS - A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR | 2010-01-21 |
20100016597 | Method for producing pulverized organic compound particle - Disclosed is a method for producing pulverized particles of a crystalline organic compound which is poorly water-soluble. Also disclosed is a pulverized organic compound particle produced by such a method. Specifically disclosed is a method for producing a poor water solubility organic compound particle for medical use, which is characterized in that a poor water solubility organic compound for medical use is mixed with a physiologically acceptable salt and a physiologically acceptable polyol, and subjected to wet milling. Also specifically disclosed is a poor water solubility organic compound particle for medical use, which is produced by such a production method. | 2010-01-21 |
20100016598 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS - The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system. | 2010-01-21 |
20100016599 | Process for Preparing Fexofenadine - A process for preparing fexofenadine is described that includes the purification of 4-[4-chloro-1-oxobutyl]-2,2-dimethylphenyl acetic acid alkyl ester by means of suspension in a hydrocarbon, preferably n-heptane. The compound thus obtained is dissolved in a suitable solvent and condensed with azacyclanol to give the compound shown below | 2010-01-21 |
20100016600 | N- and O-Substituted 4-[2-(Diphenylmethoxy)-Ethyl]-1-[(Phenyl)Methyl]Piperdine Analogs and Methods of Treating CNS Disorders Therewith - N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SERT and between the DAT and the norepinephrine transporter (NET). The compounds have utility in treating CNS disorders, including but not limited to cocaine addiction, depression, and Parkinson's disease. | 2010-01-21 |
20100016601 | PROCESS FOR PREPARING REMIFENTANIL, INTERMEDIATES THEREOF, USE OF SAID INTERMEDIATES AND PROCESSES FOR THE PREPARATION THEREOF - A process for preparing remifentanil by conversion of the nitrile group of a cyanopiperidinyl propanoate derivative to an ester group. Advantageously, with this process the number of steps for preparing remifentanil from commercial products is significantly reduced, compared to the processes known in the art. | 2010-01-21 |
20100016602 | NOVEL ARYLAMIDINE DERIVATIVE, SALT THEREOF AND ANTIFUNGAL AGENT CONTAINING THOSE - Disclosed is an arylamidine derivative represented by the following general formula: | 2010-01-21 |
20100016603 | PRODUCTION PROCESS OF 2,3'-BIPYRIDYL-6'-ONE - A production process where 2,3′-bipyridyl-6′-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3′-bipyridyl-6′-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group. | 2010-01-21 |
20100016604 | PROCESS FOR THE MANUFACTURE OF HI-6 DIMETHANESULFONATE - The invention provides a process for the manufacture of H1 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl)ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protected HI 6 product precursor, and de-protecting the precursor to form HI 6 dimethanesulfonate. | 2010-01-21 |
20100016605 | Process - A one-pot process for the preparation of pantoprazole sodium by reacting 2-chloro methyl 3,4-dimethoxy pyridine hydrochloride with 2-mercapto-5-difluoromethoxy benzimidazole in an organic solvent system in presence of a phase transfer catalyst and further treating with aqueous sodium hypohalite solution comprising sodium hydroxide to obtain pantoprazole sodium in high yield and purity. The process for conversion of pantoprazole sodium to pantoprazole sodium sesquihydrate and also pantoprazole sodium monohydrate are also disclosed herein. | 2010-01-21 |
20100016606 | PREPARATION OF AMORPHOUS HYDROUS ESOMEPRAZOLE MAGNESIUM - A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided. | 2010-01-21 |
20100016607 | Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics - The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O | 2010-01-21 |
20100016608 | LIGHT-ACTIVATED ACTUATOR ELEMENT - Disclosed is light-driven actuator element characterized in that, inter alia, it can be reduced to micrometer size, is rapidly responsive, and reversibly changes to enable repeated use. The light-driven actuator element includes a crystal of diarylethene compound which changes shape upon photoisomerization (e.g., the compound of Structural Formula (I) below, where R | 2010-01-21 |
20100016609 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS - The present invention is directed to processes, compositions and methods associated with the preparation of azole derivatives of formula I: | 2010-01-21 |
20100016610 | FRICTIONLESS MOLECULAR ROTARY MOTORS - A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided. | 2010-01-21 |
20100016611 | METHODS FOR MAKING CENTRAL NERVOUS SYSTEM AGENTS THAT ARE TRPV1 ANTAGONISTS - The invention discloses compounds of formula II: | 2010-01-21 |
20100016612 | FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME, AND FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE OBTAINED BY USING THE FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME - The present invention provides a fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same, and a fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same. | 2010-01-21 |
20100016613 | PROCESS FOR THE PREPARATION OF A BORON-SUBSTITUTED PORPHYRIN - Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH | 2010-01-21 |
20100016614 | PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE - The present invention relates to a new process for the preparation of pure perindopril erbumine. The present invention also relates to a new process for the preparation of crystalline form D of perindopril erbumine. | 2010-01-21 |
20100016615 | PROCESS FOR PRODUCTION OF HEXAFLUOROPROPYLENE OXIDE - There is provided a process for producing hexafluoropropylene oxide which is novel and capable of achieving a higher yield. An organic phase comprising hexafluoropropylene (HFP) in an organic solvent and an aqueous phase comprising an oxygen-containing oxidizing agent in water are supplied to a small space (or microspace), preferably together with a phase transfer catalyst. The organic phase and the aqueous phase are contacted with each other in the small space, thereby reacting hexafluoropropylene (HFP) with the oxygen-containing oxidizing agent, preferably by an action of the phase transfer catalyst to give hexafluoropropylene oxide (HFPO). After the reaction, the organic phase and the aqueous phase are taken out from the small space to obtain an organic phase comprising the hexafluoropropylene oxide (HFPO). | 2010-01-21 |
20100016616 | OXIDIZING AGENT COMPOSITION FOR THE EPOXIDATION OF OLEFINS AND PROCESS FOR THE EPOXIDATION OF OLEFINS - The invention aims at providing an oxidizing agent composition capable of producing halogen-free epoxy compounds in high yield; and a process for the epoxidation of olefins with the composition. In order to attain the aim, the invention provides an oxidizing agent composition for the epoxidation of olefins which is characterized by containing an acid anhydride and a solid hydrogen peroxide adduct; and a process for the epoxidation of olefins which is characterized by reacting an olefin with a mixture obtained by mixing an acid anhydride with a solid hydrogen peroxide adduct. | 2010-01-21 |
20100016617 | MULLITE-CONTAINING CARRIER FOR ETHYLENE OXIDE CATALYSTS - The present invention relates to an improved carrier for an ethylene epoxidation catalyst, the carrier comprising alumina in combination with a stability-enhancing amount of mullite. The invention is also directed to an improved catalyst containing the improved carrier, as well as an improved process for the epoxidation of ethylene using the catalyst of the invention. | 2010-01-21 |
20100016618 | CHIRAL IRIDIUM AQUA COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXY COMPOUND BY USING THE SAME - The invention relates to a chiral iridium aqua complex of formula (1): | 2010-01-21 |
20100016619 | Functionalization of the internal surfaces of zeolites with alcohol compounds - The present invention relates to the modification of the internal surfaces of zeolite crystals via treatment with alcohols containing at least four carbon atoms. The modified zeolites possess high thermal stability and the properties of the modified zeolites can be tailored to provide improved performance for use in separations processes. | 2010-01-21 |
20100016620 | PENTAKIS(DIMETHYLAMINO) DISILANE PRECURSOR COMPRISING COMPOUND AND METHOD FOR THE PREPARATION THEREOF - Pentakis(dimethylamino) disilane with general formula (1): Si2(NMe2)5Y, where Y is selected from the group comprising H, Cl or an amino group its preparation method and its use to manufacture gate dielectric films or etch-stop dielectric films of SiN or SiON. | 2010-01-21 |
20100016621 | Hydrosilylation - The present invention relates to a process for converting a substrate to a product comprising exposing the substrate to a hydrosilane in the presence of a carbene catalyst. | 2010-01-21 |
20100016622 | SILICON-CONTAINING POLYTRIMETHYLENE HOMO- OR COPOLYETHER COMPOSITION - Processes for preparing silicon-containing polytrimethylene homo- or copolyethers, wherein at least a portion of the polymer end groups are silicon-containing end groups, are provided. | 2010-01-21 |
20100016623 | PROCESS FOR REGIOSELECTIVE MONO-TOSYLATION OF DIOLS - The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for regioselective diol mono-tosylat ion, wherein Y is selected from the group of C | 2010-01-21 |
20100016624 | AQUEOUS METHODS FOR MAKING FLUORINATED SULFONATE ESTERS - Methods of making a fluorinated sulfonate ester include combining a perfluoroalkanesulfonyl halide and a fluorinated alcohol in water in the presence of hydroxide ion, and recovering at least a portion of the resultant fluorinated sulfonate ester. | 2010-01-21 |
20100016625 | METHOD FOR PRODUCING AMINONITRILES - The invention relates to a process for preparing an amino nitrile mixture comprising aminoacetonitrile (AAN) and from 5 to 70% by weight of iminodiacetonitrile (IDAN), which comprises heating crude AAN which is largely free of formaldehyde cyanohydrin (FACH-free) at a temperature of from 50 to 150° C. | 2010-01-21 |
20100016626 | PROCESS FOR PRODUCTION OF PRECURSOR COMPOUND FOR RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND - A process is provided for producing a labeled precursor which is useful for production of a radioactive fluorine-labeled amino acid compound. In the reaction step for introducing a leaving group to a mixture of syn-form and anti-form of FACBC, a base is allowed to present in the reaction system to produce a syn-leaving group adduct, which is unreactive with the base and is highly stable, and an anti-leaving group adduct which can react with the base to form a water-soluble compound. By employing a purification method utilizing such a difference in solubility, the syn-leaving group adduct can be separated selectively. The base may be a linear- or branched-chain primary to tertiary alkylamine having 1 to 10 carbon atoms, a nitrogen-containing heterocyclic compound with 2 to 20 carbon atoms, and a nitrogen-containing hetero aromatic compound with 2 to 20 carbon atoms. | 2010-01-21 |
20100016627 | PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE - A 2-formylacetic ester derivative represented by the general formula (5) is provided: | 2010-01-21 |
20100016628 | Polyester Polyol - A star-branched polyester polyol is obtained by polymerizing lactide or lactic acid, using, as an initiator, a fat and oil composed mainly of a triacylglycerol that has at least three hydroxyl groups or epoxy groups in its molecule. This polyester polyol has low crystallinity and a low melting point, and thus shows good working properties when used in various applications. Furthermore, this polyester polyol is derived from renewable resources, and, thus, it is highly desirable in view of its effectiveness in protecting the global environment and preventing fossil resources from being depleted. | 2010-01-21 |
20100016629 | PROCESS FOR PRODUCTION OF TEREPHTHALIC ACID - The invention provides a method for producing terephthalic acid, characterized by including subjecting a p-phenylene compound to liquid-phase oxidation reaction by use of a molecular-oxygen-containing gas in the presence of a catalyst at least containing a heavy metal compound and a bromine compound, and hydrous acetic acid having a water content of 1 to 15 mass %, to thereby yield a slurry; regulating the temperature of the slurry to 35 to 140° C., to thereby cause terephthalic acid to precipitate; removing the terephthalic acid through solid-liquid separation, to thereby recover a mother liquor; and recovering the catalyst from the mother liquor through a series of the following steps (1) to (4) for reusing at least a portion of the catalyst in the liquid-phase oxidation reaction: (1) an adsorption step including regulating the ratio “amount by mole of bromide ions in the mother liquor/total amount by mole of heavy metal ions in the mother liquor” to 0.6 to 3, and then exposing the mother liquor to a pyridine-ring-containing chelate resin which has been heated to 35 to 140° C., so that the resin adsorbs catalyst-derived heavy metal ions and bromide ions, and also adsorbs a carboxylic acid mixture which has been by-produced through the liquid-phase oxidation reaction, (2) an elution step (A) of exposing hydrous acetic acid having a water content of 1 to 15 mass % to the pyridine-ring-containing chelate resin which has undergone the adsorption step, thereby yielding an eluate containing the by-produced carboxylic acid mixture, (3) an elution step (B) of exposing water or hydrous acetic acid having a water content of 20 mass % or more to the pyridine-ring-containing chelate resin which has undergone the elution step (A), thereby yielding an eluate containing catalyst-derived heavy metal ions and bromide ions, and (4) a displacement step of exposing hydrous acetic acid having a water content of 1 to 15 mass % to the pyridine-ring-containing chelate resin which has undergone the elution step (B), serving as a displacement liquid, thereby regenerating the resin. | 2010-01-21 |
20100016630 | ANTIMICROBIAL DERIVATIVES OF ANACARDIC ACID AND PROCESS FOR PREPARING THE SAME - Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity. | 2010-01-21 |
20100016631 | METHOD FOR THE SYNTHESIS OF PEPTIDES WITHOUT SOLVENT - The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C | 2010-01-21 |
20100016632 | Biphenyl acetate, preparation and uses thereof - The biphenyl acetate is biphenyl acetic ammonia butantriol salt, which is obtained by reacting biphenyl acetic acid with ammonia butantriol in organic solvent. The salt is adapted to be used for producing analgesic, anti-inflammatory and antithermic medicines. | 2010-01-21 |
20100016633 | NOVEL BIS(FORMYLPHENYL)ALKANE AND NOVEL POLYNUCLEAR PHENOL DERIVED FROM THE SAME - Manufacture a novel bis(formylphenyl)alkane according to General Formula (1), as well as a novel polynuclear phenol derived therefrom, by causing a bis(hydroxymethyl-hydroxyphenyl)alkane to react with hexamethylene tetramine in the presence of an acid and hydrolyzing the reaction product, and then using the obtained bis(hydroxy-formylphenyl)alkane as a direct material and causing this material to react with halogenated alkoxycarbonyl hydrocarbon in the presence of a base. | 2010-01-21 |
20100016634 | METHOD FOR STABILIZING CARBODIIMIDE DERIVATIVE AND STABILIZED COMPOSITION THEREOF - Disclosed is a method for stabilizing a carbodiimide derivative (1) which is a condensing agent useful for production of general synthetic chemical products. Also disclosed is a stabilized composition of the carbodiimide derivative. The method is characterized in that the carbodiimide derivative (1) is handled in an atmosphere wherein the concentration of molecular oxygen in the gas phase within a container is set at not more than 3% by volume and/or in the co-presence of at least one compound selected from the group consisting of antioxidants, N-oxyl compounds, sulfur compounds, amines and Lewis acids. | 2010-01-21 |
20100016635 | SYSTEMS AND METHODS FOR INTEGRATED AMMONIA-UREA PROCESS - Systems and methods for producing urea are provided. A method for producing urea can include exchanging heat from a syngas comprising hydrogen and carbon dioxide to a urea solution comprising urea and ammonium carbamate. The heat transferred can be sufficient to decompose at least a portion of the ammonium carbamate. In one or more embodiments, the syngas can be reacted with liquid ammonia to provide a carbon dioxide lean syngas and an ammonium carbamate solution. The ammonium carbamate solution can be heated to a temperature of about 180° C. or more. At least a portion of the ammonium carbamate in the heated ammonium carbamate solution can be dehydrated to provide the urea solution. | 2010-01-21 |
20100016636 | PROCESS FOR PREPARING OPTICAL PURE MILNACIPRAN AND ITS PHARMACEUTICALLY ACCEPTED SALTS - The present invention discloses a process for preparing optically pure milnacipran and their pharmaceutically acceptable salts, which adopts racemic milnacipran as starting material, tartaric acid derivatives and their compositions as resolving agents to resolve. | 2010-01-21 |
20100016637 | Method for Producing Oxime - The present invention provides a method for producing an oxime by carrying out an ammoximation reaction of a ketone with an organic peroxide and ammonia in a solvent in the presence of a titanosilicate, characterized in that the reaction is carried out by feeding the ketone and ammonia to a reactor in which the solvent, the titanosilicate and the organic peroxide are charged. | 2010-01-21 |
20100016638 | Method for preparation of o-desmethylvenlafaxine using polythiolates - This invention relates to methods of making O-desmethylvenlafaxine from venlafaxine. In the methods venlafaxine is contacted with a polythiolate. The polythiolate may be prepared from the corresponding polythiol in the presence of base. The present methods provide the O-desmethylvenlafaxine in good yields and high purity and are suitable for use on an industrial scale. | 2010-01-21 |
20100016639 | PRODUCTION OF CHIRALLY PURE AMINO ALCOHOL INTERMEDIATES, DERIVATIVES THEREOF, AND USES THEREOF - A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl. | 2010-01-21 |
20100016640 | SHELL CATALYST, IN PARTICULAR FOR OXIDATION OF METHANOL TO FORMALDEHYDE, AND ALSO METHOD FOR PRODUCTION THEREOF - The invention relates to a coated catalyst, especially for oxidation of methanol to formaldehyde, which, on an inert, preferably essentially nonporous, support body, has at least one coating which comprises, before the removal of the organic fractions of components b) and c): (a) oxides, or precursor compounds convertible to the corresponding oxides, of molybdenum and iron, where the molar ratio of Mo:Fe is between 1:1 and 5:1, and optionally further metallic components or metal oxide components or precursor compounds convertible to the corresponding oxides, (b) at least one organic binder, preferably an aqueous dispersion of copolymers, especially selected from vinyl acetate/vinyl laurate, vinyl acetate/ethylene, vinyl acetate/acrylate, vinyl acetate/maleate, styrene/acrylate or mixtures thereof, and (c) at least one further component selected from the group consisting of SiO | 2010-01-21 |
20100016641 | CONVERSION OF GLYCEROL TO NAPHTHA-RANGE OXYGENATES - The invention provides a method of converting glycerol to oxygenates (i.e. one or more oxygen-containing hydrocarbons) of lower boiling point than glycerol itself The method involves reaction of glycerol with an alcohol under reduced pressure at a reaction temperature in a range of 150 to 300° C. in the presence of an oxygenation (solid acid) catalyst. The reaction product contains volatile oxygenates that may be used as fuels or fuel additives. | 2010-01-21 |
20100016642 | RECOVERY OF PHENOL LIGANDS DURING THE PRODUCTION OF ISOPULEGOL - The present invention relates to a method of working up an aluminum-containing reaction product from the production of isopulegol by cyclization of citronellal in the presence of complex compounds, comprising at least one ligand of the formula (I), | 2010-01-21 |
20100016643 | PROCESS FOR PREPARING 1,4-BUTANEDIOL - The present invention provides an integrated process for continuously preparing 1,4-butanediol, which comprises the following stages: | 2010-01-21 |
20100016644 | MALEIC ANHYDRIDE CATALYST AND METHOD FOR ITS PREPARATION - The present invention provides a process for producing a vanadium/phosphorus oxide catalyst by (i) preparing a catalyst precursor powder containing vanadium, phosphorus and an optional promoter element; (ii) converting the catalyst precursor powder into an activated catalyst by heat treatment; (iii) and compressing the activated catalyst into a desired shape to form the vanadium/phosphorus oxide catalyst. The vanadium/phosphorus oxide catalyst may be used in the production of maleic anhydride by the catalytic oxidation of hydrocarbon feed streams. | 2010-01-21 |
20100016645 | Process for hydrogenation of benzene - This invention relates to a process for hydrogenation of benzene contained in a catalytic reformate, in which:
| 2010-01-21 |
20100016646 | PROCESS FOR HYDROGENATING BUTADIYNE - In the process for hydrogenating butadiyne over a catalyst which comprises at least one platinum group metal on an inorganic metal oxide as a support, the hydrogenation is performed at a pressure in the range from 1 to 40 bar and a temperature in the range from 0 to 100° C., and from 0.05 to 5% by weight, based on the overall catalyst, of platinum group metal is present on the support. | 2010-01-21 |
20100016647 | CATALYST FOR AROMATIZATION OF LOWER HYDROCARBONS AND PROCESS FOR PRODUCTION OF AROMATIC COMPOUNDS - A catalyst for producing aromatic compounds from lower hydrocarbons while improving activity life stability of methane conversion rate; benzene formation rate; naphthalene formation rate; and total formation rate of benzene, toluene and xylene is formed by loading molybdenum and copper on metallo-silicate serving as a substrate and then calcining the metallo-silicate. When the catalyst is reacted with a reaction gas containing lower hydrocarbons and carbonic acid gas, aromatic compounds are produced. In order to obtain the catalyst, it is preferable that molybdenum and copper are loaded on zeolite formed of metallo-silicate after the zeolite is treated with a silane compound larger than a pore of the zeolite in diameter and having an amino group and a straight-chain hydrocarbon group, the amino group being able to selectively react with the zeolite at a Bronsted acid point of the zeolite. It is preferable that a loaded amount of molybdenum is within a range of from 2 to 12 wt. % based on total amount of the calcined catalyst while copper is loaded at a copper to molybdenum molar ratio of 0.01 to 0.8. | 2010-01-21 |
20100016648 | METHOD FOR INCREASING YIELDS OF ETHYLENE AND PROPYLENE IN MTO PROCESS - The present invention discloses a method for enhancing yields of ethylene and propylene in MTO process, comprising: i) feeding a feedstock comprising C | 2010-01-21 |
20100016649 | External Beam Radiotherapy And Imaging With Radioactive Isotope - A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source. | 2010-01-21 |
20100016650 | Magnetic stimulators and stimulating coils - A stimulating coil for use in the magnetic stimulation of neuro-muscular tissue comprises a self-supporting but flexible conductor in a flexible insulating sheath which can be adjusted by hand to conform the coil to the contours of a selected part of the human body. The coil is provided with a cooling system which includes a conduit disposed adjacent or within the coil and a pump for driving coolant through the conduit. | 2010-01-21 |
20100016651 | METHODS TO ARREST CANCER CELL GROWTH AND PROLIFERATION USING ELECTROMAGNETIC ENERGY DELIVERED VIA ELECTROMAGNETIC COIL SYSTEMS - A non-invasive method of using electromagnetic field energies to reduce or arrest the growth rate and proliferation of cancer cells, and induce apoptosis in cancer cells, relatively without significantly harming normal cells beyond their physiologic threshold of survival are provided. The methods described herein are intended to be used toward the treatment of cancer in human or animals within the context of cancer therapeutics. | 2010-01-21 |
20100016652 | PATIENT-ADJUSTABLE INCONTINENCE DEVICE (AID) - A patient-adjustable device and surgical method for the treatment of urinary incontinence is disclosed herein. More specifically, the device is a mesh surrounded pillow which is implanted near the attachment of the urethra to the bladder, or mid to distal urethra which can be controlled by the patient. The fullness of the pillow can be controlled by the patient using two pressure-sensitive controls under the skin. | 2010-01-21 |
20100016653 | Quantitative Trait Loci and Somatostatin - The disclosure relates to the use of genetic traits in livestock for determining breeding characteristics of livestock progeny, and for optimizing the management and marketing of livestock for improving feedlot performance and meat quality. The disclosure specifically relates to genetic markers and single nucleotide polymorphisms (SNPs) in the bovine somatostatin locus, as well as haplotypes that include the somatostatin locus, which are associated with certain quantitative trait loci (QTLs), such as marbling, meat quality grade, and yield grade. In a preferred embodiment, the SNPs and haplotypes are predictive of the increased or decreased amount of tissue marbling in the animal. | 2010-01-21 |
20100016654 | Methods of Minimizing Immunological Rejection of A Nuclear Transfer Fetus - The present invention relates to a method of minimizing immunological rejection of a nuclear transfer (“NT”) fetus which includes transferring a NT embryo into an embryo recipient under conditions effective for development of a NT fetus with minimal risk of immunological rejection of the fetus due to a maternal anti-fetal MHC-I immune response. After determining an MHC-I antigen type for a NT embryo and an MHC-I antigen type for embryo recipients, the NT embryo is either (i) transferred into a first embryo recipient having a compatible MHC-I antigen type under conditions effective for development of a NT fetus from the NT embryo, or (ii) transferred into a second embryo recipient having an incompatible MHC-I antigen type, followed by regulating MHC-I expression of the NT embryo or suppressing an immune response of the embryo recipient under conditions effective for development of a nuclear transfer fetus. | 2010-01-21 |
20100016655 | Cardiac Anchor Structures, Methods, and Systems for Treatment of Congestive Heart Failure and Other Conditions - Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and/or slowed. | 2010-01-21 |
20100016658 | ANATOMICAL VISUALIZATION AND MEASUREMENT SYSTEM - A method for deploying a device in a tortuous vessel, comprising:
| 2010-01-21 |
20100016659 | Endoscope With Guide - An instrument for use with an endoscope may include an elongate section configured to move exterior to the endoscope. The elongate section may include a distal end and a proximal end. The instrument may also include an end effector attached to the distal end of the elongate section, and an actuation device attached to the proximal end of the elongate section. The actuation device may be configured to operate the end effector. The instrument may also include a guiding member coupled to the elongate section. The guiding member may be configured to be coupled to an external surface of the endoscope to permit the guiding member to move longitudinally relative to the endoscope. The guiding member may be coupled to the elongate section such that the end effector may extend past a distal end of the endoscope and move in a transverse direction independent of the movement of the distal end of the endoscope. | 2010-01-21 |
20100016660 | BENDING NECK FOR TRANSESOPHAGEAL ECHOCARDIOGRAPHY (TEE) PROBE - The invention provides articles of manufacture and methods for producing and using a bending neck assembly for a medical probe, using a tubular structure having a region of helical groove. | 2010-01-21 |
20100016661 | RECEIVING APPARATUS AND IN-VIVO INFORMATION ACQUIRING SYSTEM USING THE SAME - An object of the invention is to receive, with a high sensitivity, a radio signal transmitted within a short time before a capsule endoscope reaches the stomach of a subject and acquire, in a satisfactory state, information on the interior of the subject such as image data picked up by the capsule endoscope. The receiving apparatus according to the invention includes a plurality of receiving antennas including a specified receiving antenna for receiving a radio signal from a capsule endoscope before the stomach is reached, a switching controller, an arrival determining unit and a mode switching unit. The switching controller performs a control operation for switching to and maintaining the receiving antenna in an initial mode or a control operation for switching to the receiving antennas in a normal mode. The arrival determining unit determines whether the capsule endoscope has reached the stomach or not. The mode switching unit instructs the switching controller to perform the control operation for switching to the initial mode, and upon determination that the stomach has been reached, gives the instruction to perform the control operation for switching to the normal mode. | 2010-01-21 |
20100016662 | Radial Scanner Imaging System - A radial scanner configured to image the interior of a tube includes, in an embodiment, a housing having a transparent window, a photo-sensing array, a mirror located within the housing and oriented to direct an image around a circumference of an interior surface of the tube outside the transparent window to the photo-sensing array, and a light source configured to illuminate the interior surface of the tube, wherein the photo-sensing array is configured to receive the image around the circumference as a circular line scan. In an embodiment, the radial scanner is deployed as an ingestible capsule. In another embodiment, the radial scanner is deployed as a fiber optic catheter. | 2010-01-21 |
20100016663 | Device for the Guidance of Instruments in Cavities - The invention relates to an arrangement which can be fixed to the inside of a cavity by means of fixing means which are associated with said arrangement. Said fixing means fix the arrangement in relation to at least one part of the wall of the cavity which is to be examined, wherein the arrangement must at least partially be inserted. Said arrangement enables the instruments, which are used to examine/manipulate cavities, even when the arrangement and/or the instrument is displaced in a translatory and/or rotational manner, in particular, in angled cavities, to be guided in a reliable manner. | 2010-01-21 |
20100016664 | SURGICAL VISUAL OBTURATOR - An obturator apparatus for penetration of tissue and for permitting visualization includes an elongated shaft having proximal and distal ends, and defining a longitudinal axis and an optical transmitting member mounted adjacent the distal end of the elongated shaft. The optical transmitting member comprises a transparent material for permitting passage of light therethrough and has internal surfaces defining a hollow internal chamber and external surfaces adapted to penetrate tissue. The optical transmitting member is further adapted to provide an inclined field of view inclined relative to the longitudinal axis. The elongated shaft may include a longitudinal opening adapted for reception of an endoscope. | 2010-01-21 |
20100016665 | CATHETER INTRODUCER SYSTEM FOR EXPLORATION OF BODY CAVITIES - A catheter introducer system for endoscopy is disclosed which includes a steering section and a propulsion section located near the end of the catheter that is introduced in a body cavity, and a non-collapsible sheath defining a working channel, disposed inside the catheter, extending substantially from the proximate to the distal end and maintaining a substantially circular cross-section even when bent along an axis. The propulsion section is designed to pull the rest of the catheter inside the body cavity, so there is no need to push the catheter along. The catheter can thus be made very flexible in bending, and a larger diameter catheter can be used without discomfort to the patient. | 2010-01-21 |
20100016666 | SURGICAL INSTRUMENT POSITION CONTROL APPARATUS FOR ENDOSCOPE - An endoscopic system includes a surgical instrument position control apparatus. The surgical instrument position control apparatus estimates motion of an endoscope main body with respect to a target site, based on an image picked up in conjunction with movement of an endoscope. To determine the moving amount of the surgical instrument, the surgical instrument position control apparatus calculates the amounts of operations, such as bending, rotation, and forward and backward movements, of each joint of a surgical arm section which amounts are required to move the surgical instrument from a position taken by the surgical instrument after movement of the endoscope to a surgical procedure position. The surgical instrument position control apparatus thus bends each joint to move the surgical section to the original surgical procedure position so as to hold the position of the surgical instrument every time the endoscope is moved. | 2010-01-21 |
20100016667 | CAPSULE MEDICAL DEVICE AND METHOD OF MANUFACTURING CAPSULE MEDICAL DEVICE - A method of manufacturing a capsule medical device includes mounting one or more functional components on each of a first circuit board group and a second circuit board group, which are separate bodies from each other; mounting a control unit that controls an operation of the one or more functional components, on a control board that is a separate body from the first circuit board group and the second circuit board group; and connecting the first circuit board group and the second circuit board group to the control board. | 2010-01-21 |
20100016668 | MEDICAL DEVICE FOR DISCREETLY PERFORMING A ROUTINE VAGINAL EXAMINATION - The invention is a system for performing a routine vaginal examination. The examination is carried out using a medical imaging device that is optimally shaped to match the shape of the vaginal canal and comprises an imaging sensor, wide field of view optics, illumination means, electronic circuitry, and communication means. In addition a medical image and analysis (MIUA) unit comprising a processor and a dedicated MIUA algorithm is provided, either as part of the device or as a separate unit. The system is characterized in that the dedicated MIUA algorithm compares the acquired images to a predefined standard of quality and verifies that sufficient images of a predefined region of interest (ROI) have been obtained; saves the acquired images that meet the predefined standard and also show the ROI; and signals the user carrying out the examination when a sufficient number of images having sufficient image quality and taken at appropriate viewing angles of the area being examined have been acquired. The device and MIUA unit enable routine examination of the vagina to be carried out at any location by untrained persons, preferably by the woman herself in the privacy of her own home. The images acquired by the camera are transmitted to an authorized center where trained medical personnel view, analyze, and interpret them. | 2010-01-21 |
20100016669 | FLUORESCENCE ENDOSCOPE SYSTEM - Provided is a fluorescence endoscope system for observing fluorescence from a fluorochrome attached to or absorbed in biological tissue, including an excitation light source that emits excitation light that excites the fluorochrome; an image-acquisition section that acquires fluorescence emitted from the biological tissue when irradiated with the excitation light from the excitation light source; an autofluorescence signal setting section that sets an autofluorescence signal intensity to be emitted from the biological tissue when irradiated with the excitation light; and an image compensation section that compensates fluorescence image information acquired by the image-acquisition section on the basis of the autofluorescence signal intensity set by the autofluorescence signal setting section. | 2010-01-21 |
20100016670 | CAPSULE MEDICAL DEVICE AND METHOD OF MANUFACTURING CAPSULE MEDICAL DEVICE - A capsule medical device introduced into a subject includes an illuminating unit that illuminates inside of the subject; an imaging unit that captures an image of inside the subject illuminated by the illuminating unit; an optical unit including a lens group that forms the image of inside the subject illuminated by the illuminating unit onto a light receiving surface of the imaging unit and a lens frame for holding the lens group; and an illuminating board having a bending part extending to a part of an outer circumference and an opening part capable of inserting the lens frame thereinto formed thereon, and having the illuminating unit mounted thereon. At least one of the opening part and the lens frame has a shape capable of avoiding a contact between the illuminating board, which turns while bending the bending part, and an upper end of the lens frame. | 2010-01-21 |
20100016671 | ENDOSCOPE WITH RESISTANCE HEATER - A medical endoscope and insertion portion for a medical endoscope having a fiber tube that encloses an image guide and is surrounded by optical fibers, the distal opening of said fiber tube being sealed by a window, which is heated by an electric resistance heater located close by, wherein the heater is designed as heating foil arranged on the outer surface of the fiber tube. | 2010-01-21 |
20100016672 | CAPSULE MEDICAL DEVICE AND METHOD OF MANUFACTURING CAPSULE MEDICAL DEVICE - A capsule medical device includes an optically transparent optical dome forming a part of a capsule casing introduced into a subject; an illuminating board having an illuminating unit that illuminates inside the subject over the optical dome fixedly arranged thereon; an optical unit that forms an image of inside the subject illuminated by the illuminating unit; an imaging unit that is fixedly arranged with respect to the optical unit and captures images of inside the subject; and a positioning unit in which the illuminating board and the optical unit are fixedly arranged, which is fitted and fixed to an inner circumference of the optical dome to determine relative positions of the illuminating board and the optical unit with respect to the optical dome. | 2010-01-21 |
20100016673 | Ingestible Endoscopic Optical Scanning Device - An ingestible scanning device includes, in an embodiment, a capsule housing having a transparent window and sized so as to be ingestible, a photo-sensing array located within the capsule housing, a mirror located within the housing and oriented to direct an image from a surface outside the transparent window to the photo-sensing array, and a light source for illuminating the surface outside the transparent window. | 2010-01-21 |
20100016674 | VAGINAL SPECULUM - An inflatable vaginal speculum that includes diametrically and longitudinally expandable sidewalls with openings allowing observation of vaginal walls along the length of the speculum and a central opening allowing viewing down the length of the speculum to the cervix. The speculum may be positioned within an envelope together with a sterile saline solution. An array of the envelopes can be stored in a storage box together with bulb-type pump such as used with a blood pressure cuff. The envelope is opened by tearing down one side so that the speculum can be removed. | 2010-01-21 |
20100016675 | Method of assessing a condition using sucking patterns - A method of assessing a condition includes comparing a sucking pattern for a target infant with a sucking pattern associated with the condition. A method of monitoring progress of a treatment includes comparing the rhythmic sucking percentage for a target infant before treatment for a condition with the rhythmic sucking percentage for the infant after treatment of the condition to assess the effectiveness of the treatment. A method of monitoring progress of a treatment includes using sucking patterns to compare an infant's rate of progress at a given point in time to a population's rate of progress at the same point in time. | 2010-01-21 |
20100016676 | Systems And Methods For Adaptively Filtering Signals - According to embodiments, systems and method are provided for adaptively filtering signals. A combination of filtering techniques is described in which non-wavelet based filtering techniques are used with wavelet-based filtering techniques to filter an input signal. One or more physiological parameters may then be determined from the filtered output signal. | 2010-01-21 |
20100016677 | Devices for and Methods of Analyzing a Physiological Condition of a Physiological Subject Based on A Workload Related Property - A method of influencing a physiological condition of a physiological subject, the method comprising detecting a workload distribution/activity in a brain of the physiological subject, the workload distribution/activity being indicative of the physiological condition, and selectively modifying the workload distribution/activity in the brain of the physiological subject to thereby modify the physiological condition. | 2010-01-21 |
20100016678 | CARDIAC REHABILITATION USING PATIENT MONITORING DEVICES - Systems and methods permit remotely-monitored rehabilitation of a patient. A system can comprise a patient monitor configured to monitor a patient's physiological data. The patient monitor can monitor using a first monitoring mode. A patient communication device can be configured to present, to the patient, an option to perform an exercise regimen, and to receive a response indicating whether the patient will perform the exercise regimen. A configuration module coupled to the patient communication device can be configured to activate a second monitoring mode when the response indicates that the patient will perform the exercise regimen. When the exercise regimen is complete, the first monitoring mode can be re-established. When the response indicates that the patient will not perform the exercise regimen, the response can be recorded as a negative response, and the option to perform the exercise regimen can be presented again. | 2010-01-21 |
20100016679 | Apparatus and Method for the Identification of a Subject Memory Trace and for the Intention Prevision - An apparatus and method for the identification of a subject's memory trace and for intention prediction use a procedure for acquiring information by means of administering to the subject a series of tests; the apparatus records the answers and the reaction times of the subject and it elaborates the results in order to give, with an accuracy of 92%, the memory trace or the intention of the subject. The apparatus and method give the possibility to avoid or identify maligners and fakers. | 2010-01-21 |
20100016680 | Signal Processing Systems and Methods for Analyzing Multiparameter Spaces to Determine Physiological States - The present disclosure relates to signal processing systems and methods, and more particularly, to systems and methods for analyzing multiparameter spaces to determine changes in a physiological state. In embodiments, a first signal and a second signal may be obtained, from which a first plurality of values of a physiological parameter may be determined. At least one of the signals also may be used to generate a scalogram derived at least in part from the signal. A second plurality of values may be determined based at least in part on a feature in the scalogram. The first and second plurality of values may then be associated, and a physiological state may be analyzed using the associated first and second values. In an embodiment, the signals may be PPG signals and the associated first and second values may include a parameter scatter plot that may permit a user to determine changes in a patient's ventilation state over time. | 2010-01-21 |
20100016681 | Apparatus and Methods for Monitoring Physiological Functions - A plurality of sensors are embedded in a form fitting garment similar to exercise togs such that the sensors are held in contact with or close proximity to the body. The sensors are connected via a plurality wires to an electronics module which is unintrusive being literally in its ultimate configuration the size of a credit card. A range of thickness, from 6 mm (6 credit cards) down to 1 mm or less, is possible for the module inclusive of a rechargeable lithium polymer battery. The electronics module can be easily removed for garment maintenance (laundering). | 2010-01-21 |
20100016682 | PATIENT MONITORING SYSTEM AND METHOD - The present invention relates to a patient monitoring system ( | 2010-01-21 |
20100016683 | SMART INSTALL - When installing components of a remote patient health monitoring system ( | 2010-01-21 |
20100016684 | ELECTRONIC DEVICE AND SYSTEM FOR DETECTING REJECTION IN TRANSPLANT RECIPIENTS - The current invention relates to an implantable device, system, method, and computer readable medium comprising computer executable components for detection of rejection of a cardiac allograft. Acute rejection and chronic rejection are the leading cause of death in heart transplant recipients post transplant. The current invention seeks to address this problem by providing methods, devices, systems and computer readable media comprising computer executable components to monitor the efficacy of immunosuppressant therapy and evaluate the degree of rejection in a cardiac allograft. To provide this functionality, an implantable device comprises sensors which measure physiologic parameters at specified intervals after the transplant procedure. These measured parameters are subsequently compared with baseline parameter data to detect rejection of the cardiac allograft. | 2010-01-21 |
20100016685 | BALLISTOCARDIOGRAPHIC SENSOR SYSTEM WITH A SENSOR ARRANGEMENT AND METHOD OF BALLISTOCARDIOGRAPHIC DETECTION OF BODY MOVEMENTS - Sensor arrangement, comprising at least one ballistocardiographic sensor for detecting body movements of a subject and at least one noise sensor for detecting vibration, method of ballistocardiographic detection of body movements, ballistocardiographic sensor system and uses of the sensor arrangement. It is suggested to pickup an external noise signal using an inertia sensor that is vibration isolated from a subject under ballistocardiographic examination. | 2010-01-21 |
20100016686 | HAND-HELD ELECTRIC FIELD IMAGER FOR MEASURING THE SURFACE TOPOGRAPHY OF MAMMALIAN SKIN AND OTHER EPITHELIAL STRUCTURES - The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface. | 2010-01-21 |
20100016687 | SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. | 2010-01-21 |
20100016688 | Optical methods for real time monitoring of tissue treatment - The present invention comprises methods and systems/devices for non-invasively measuring baseline collagen and collagen changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules. | 2010-01-21 |
20100016689 | METHOD FOR NONINVASIVE MEASUREMENT OF GLUCOSE AND APPARATUS FOR NONINVASIVE MEASUREMENT OF GLUCOSE - A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals. | 2010-01-21 |