02nd week of 2021 patent applcation highlights part 23 |
Patent application number | Title | Published |
20210009474 | A Heating Element Comprising Chromium Alloyed Molybdenum Disilicide And The Use Thereof - The present disclosure relates to a heating element, wherein at least one part of the heating element is manufactured from a molybdenum disilicide composition and wherein in the molybdenum disilicide composition, molybdenum is substituted by chromium according to (Mo | 2021-01-14 |
20210009475 | A Heating Element - The present disclosure relates to a heating element comprising at least two parts which are composed of different molybdenum disilicide-based compositions, wherein at least one of the molybdenum disilicide-based parts is based on a chromium-alloyed based molybdenum disilicide composition ((Mo | 2021-01-14 |
20210009476 | BAKING SLURRY COMPOSITION, GREEN SHEET, METHOD FOR MANUFACTURING GREEN SHEET, METHOD FOR MANUFACTURING SINTERED PRODUCT, AND METHOD FOR MANUFACTURING MONOLITHIC CERAMIC CAPACITOR - A baking slurry composition of the present invention contains an amino alcohol compound represented by formula, inorganic powder , a polyvinyl alcohol resin, and water. In the formula, | 2021-01-14 |
20210009477 | BAKING SLURRY COMPOSITION, GREEN SHEET, METHOD FOR MANUFACTURING GREEN SHEET, METHOD FOR MANUFACTURING SINTERED PRODUCT, AND METHOD FOR MANUFACTURING MONOLITHIC CERAMIC CAPACITOR - A baking slurry composition for producing a green sheet of the present invention contains inorganic powder, a polyvinyl alcohol resin, acrylic polymer, and water. The acrylic polymer has a glass transition temperature higher than or equal to −50° C. and lower than or equal to 30° C. and an acid value greater than or equal to 50 mg KOH/g and less than or equal to 200 mg KOH/g. The acrylic polymer has a weight percentage of more than or equal to 0.1 and less than or equal to 5.0 relative to a total solid content of the baking slurry composition. | 2021-01-14 |
20210009478 | GREEN SHEET PRODUCING BINDER COMPOSITION, BAKING SLURRY COMPOSITION, METHOD FOR MANUFACTURING GREEN SHEET, METHOD FOR MANUFACTURING SINTERED PRODUCT, AND METHOD FOR MANUFACTURING MONOLITHIC CERAMIC CAPACITOR - A green sheet producing binder composition of the present invention is a binder composition for producing a green sheet. The binder composition contains a polyvinyl alcohol resin. The polyvinyl alcohol resin contains at least two kinds of components having degrees of hydrophilicity different from each other. | 2021-01-14 |
20210009479 | VACUUM INFILTRATION SYSTEM FOR CERAMIC MATRIX COMPOSITES - A method for infiltrating a porous preform for a gas turbine engine is provided, which comprises providing a chamber for infiltrating a porous preform. The porous preform is positioned within a slurry confinement fixture within the chamber. A vacuum is created in the chamber. A solvent is added to the slurry confinement fixture until a pressure in the chamber is substantially equal to an equilibrium partial pressure of the solvent. A slurry is added to the slurry confinement fixture. The slurry includes the solvent and a particulate. The pressure in the chamber is increased, and the slurry is urged into the porous preform. | 2021-01-14 |
20210009480 | METHOD OF ALTERING A SURFACE OF A CERAMIC MATRIX COMPOSITE TO AID IN NODULE REMOVAL - A method of altering a surface of a ceramic matrix composite to aid in nodule removal is described. A fiber preform comprising a framework of ceramic fibers is heated to a temperature at or above a melting temperature of silicon. During the heating, the fiber preform is infiltrated with a molten material comprising silicon. After the infiltration, the fiber preform is cooled, and the infiltrated fiber preform is exposed to a gas comprising nitrogen during cooling. Silicon nitride may be formed by a reaction of free (unreacted) silicon at or near the surface of the infiltrated fiber preform with the nitrogen. Thus, a ceramic matrix composite having a surface configured for easy nodule removal is formed. Any silicon nodules formed on the surface during cooling may be removed without machining or heat treatment. | 2021-01-14 |
20210009481 | METHOD FOR MANUFACTURING ORGANIC LIQUID FERTILIZER - Systems and methods for manufacturing an organic liquid fertilizer product are shown. The contemplated systems and methods are configured to treat waste from a natural source in order to produce the organic liquid fertilizer. The liquid organic waste may be derived from an organic source. The liquid organic waste may be pre-treated through an anaerobic digestion process, or it may be treated in a raw form. Advantageously, the systems and methods of the present disclosure may be used to manufacture the organic liquid fertilizer with a sufficiently high nitrogen content, which is usable by plants and crops. The systems and methods are likewise more efficient than known systems and methods to produce such fertilizer products. | 2021-01-14 |
20210009482 | MINERAL SOLUBILIZING MICROORGANISM INFUSED BIOCHARS - A treated biochar comprising a porous carbonaceous particle that has been treated and mixed with a media containing a mineral solubilizing microorganism, whereby the porous carbonaceous particle after mixing has retained the mineral solubilizing microorganism. | 2021-01-14 |
20210009483 | METHODS AND COMPOSITIONS FOR IMPROVING PLANT TRAITS - Methods and systems are provided for generating and utilizing a bacterial composition that comprises at least one genetically engineered bacterial strain that fixes atmospheric nitrogen in an agricultural system that has been fertilized with more than 20 lbs of Nitrogen per acre. | 2021-01-14 |
20210009484 | BODILY REMAINS DECOMPOSITION - An organic composition for decomposing bodily remains including a composite mixture of compost, peat, sulfur, and gypsum. The composite mixture is configured to combine with the bodily remains to decompose the bodily remains. The combined mixture has a reduced pH for reducing the detrimental effects of the bodily remains on the environment. | 2021-01-14 |
20210009485 | FERTILIZER COATING METHOD - Disclosed is a method of coating fertilizer particles with a coating, the method comprising providing fertilizer particles in a coating unit, one or more steps of applying a coating layer by applying one or more coating components to the fertilizer particles in the coating unit, and at least, partially curing or hardening the coating layer, wherein said curing or hardening involves a chemical reaction of said one or more coating components, discharging the coated fertilizer particles from the coating unit, optionally after a final cure or hardening step, wherein the coating unit comprises a stationary frame and at least two movable elements. | 2021-01-14 |
20210009486 | Linear Alpha Olefin Processes - The present disclosure provides assemblies for producing linear alpha olefins and methods for producing linear alpha olefins. In at least one embodiment, a method for producing a linear alpha olefin includes oligomerizing an olefin in the presence of a catalyst and a process solvent in at least one reactor, quenching the reactor effluent, and subjecting the quenched effluent to separation steps to obtain a stream enriched in one or more linear alpha olefins. | 2021-01-14 |
20210009487 | PRODUCTION METHOD FOR P-XYLENE - A method for producing p-xylene, comprising: a dimerization step of bringing a first raw material comprising isobutene into contact with a dimerization catalyst to generate C8 components comprising diisobutylene; a cyclization step of bringing a second raw material comprising the C8 components into contact with a dehydrogenation catalyst comprising Pt in the presence of water to obtain a reaction product comprising p-xylene; and a collection step of collecting p-xylene from the reaction product. | 2021-01-14 |
20210009488 | PRODUCTION METHOD FOR P-XYLENE - A method for producing p-xylene, comprising: a dimerization step of bringing a first raw material comprising isobutene into contact with a dimerization catalyst to generate C8 components comprising diisobutylene; a cyclization step of bringing a second raw material comprising the C8 components into contact with a dehydrogenation catalyst comprising Pt in the presence of hydrogen to obtain a reaction product comprising p-xylene; and a collection step of collecting p-xylene from the reaction product. | 2021-01-14 |
20210009489 | 11-HALO-3-UNDECENE COMPOUND AND A PROCESS FOR PREPARING THE SAME AND A PROCESS FOR PREPARING 9-DODECENAL COMPOUND - The present invention provides a process for preparing an 11-halo-3-undecene compound (7) in which X | 2021-01-14 |
20210009490 | METHOD FOR RECYCLING CATALYST IN THE PRODUCTION OF CHLORINATED ALKANES - The present invention provides highly efficient processes for the preparation of chlorinated alkanes. The processes comprise contacting an alkene, halogenated alkene, or combinations thereof, a halogenated methane comprising at least one chlorine atom, at least one solid metallic catalyst, and a ligand forming a reaction mixture in a reactor. The product mixture does not contain a phase transfer catalyst. After a product mixture is formed, various fractions, distillation streams, and effluent streams are separated and/or treated with an aqueous alkaline substance. This treatment removes at least a portion of the metal and through recycling of the heavy fraction, treated product mixture, or combinations thereof, allows for the kinetics of the process to be maintained or increased. | 2021-01-14 |
20210009491 | PHOTOCHLORINATION OF CHLOROFORM TO CARBON TETRACHLORIDE - A method of producing carbon tetrachloride, the method comprising the step of reacting chlorine with chloroform in the presence of electromagnetic radiation within a reaction mixture that includes the chlorine, the chloroform, and carbon tetrachloride, where the concentration of chloroform is less than 5000 ppm by weight relative to the weight of the reaction mixture, where the reaction mixture includes at least stoichiometric levels of chlorine relative to chloroform, where the electromagnetic radiation creates chloride radicals, and where the reaction mixture is well mixed. | 2021-01-14 |
20210009492 | DIRECT HYDROXYLATION OF BENZENE TO PHENOL - The invention provides a method for preparing phenols from aromatic compounds, particularly a method of preparing phenol by direct hydroxylation of benzene. The method comprises contacting benzene with nitrous oxide in the presence of a bimetallic zeolite catalyst at an ambient pressure and a reaction temperature ranging from (about) 320° C. to 440° C. | 2021-01-14 |
20210009493 | METHOD FOR MANUFACTURING DIMETHYLOLBUTANAL AND METHOD FOR MANUFACTURING TRIMETHYLOLPROPANE USING SAME - A method for preparing dimethylolbutanal including performing an aldol reaction of n-butyraldehyde (n-BAL) and paraformaldehyde (PFA) in the presence of water and an alkylamine catalyst, in which a weight ratio of the paraformaldehyde:water is 1:0.35 to 1:0.85. | 2021-01-14 |
20210009494 | Menaquinol Compositions and Methods of Treatment - The present application discloses methods for the efficient preparation of high purity compounds of the Formula I, and their methods of use. | 2021-01-14 |
20210009495 | METHOD FOR THE ISOMERIZATION OF A 3-(Z)-UNSATURATED CARBOXYLIC ACID TO THE 3-(E)-ISOMER - The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula 1-Z or a salt thereof, wherein R | 2021-01-14 |
20210009496 | PRODUCTION AND SEPARATION OF 3-HYDROXYPROPIONIC ACID - The disclosure provides methods and apparatus for producing 3-hydroxypropionic acid or a salt thereof, for removing | 2021-01-14 |
20210009497 | QUINONES HAVING HIGH CAPACITY RETENTION FOR USE AS ELECTROLYTES IN AQUEOUS REDOX FLOW BATTERIES - We disclose quinone compounds and related species (Formula I) that possess significant advantages when used as a redox active material in a battery, e.g., a redox flow battery. In particular, the compounds provide redox flow batteries (RFBs) with extremely high capacity retention. For example, RFBs of the invention can be cycled for 500 times with negligible loss of capacity, and such batteries could be employed for years of service. Thus, the invention provides a high efficiency, long cycle life redox flow battery with reasonable power cost, low energy cost, and all the energy scaling advantages of a flow battery. | 2021-01-14 |
20210009498 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE - Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA. | 2021-01-14 |
20210009499 | METHOD FOR PRODUCING UNSATURATED CARBOXYLIC ESTER - An object of the present invention is to provide a method for producing an unsaturated carboxylic ester, wherein the risk of polymerization blockage is reduced and the required equipment cost and workload involved are kept low while maintaining a high conversion rate in an esterification reaction of unsaturated carboxylic acid. This object can be achieved by a method for producing an unsaturated carboxylic ester, which includes performing an esterification reaction using a reactor packed with a solid catalyst, wherein unsaturated carboxylic acid and alcohol are continuously fed to the reactor from an inlet thereof to form a fluid of the reaction solution in the reactor, and the vaporized organic solvent is continuously fed to the reactor from the inlet or a part near the inlet of the reactor. | 2021-01-14 |
20210009500 | METHOD FOR PRODUCING FATTY ACID POLYOXYETHYLENE METHYL ETHER - A method for producing a fatty acid polyoxyethylene methyl ether in which ethylene oxide is added to a fatty acid methyl ester component comprising, as a main component, a fatty acid methyl ester having a fatty acid residue of 18 to 22 carbon atoms, the addition being conducted in the presence of a composite metal oxide catalyst and at least one alcohol selected from the group consisting of diethylene glycol, ethylene glycol, propylene glycol, ethanol, methanol and isopropyl alcohol. | 2021-01-14 |
20210009501 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF - The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension. | 2021-01-14 |
20210009502 | CARBONATE-LINKED SURFACE MODIFYING MACROMOLECULES - The invention relates to carbonate-linked surface modifying macromolecules and admixtures thereof. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules). | 2021-01-14 |
20210009503 | IONIZABLE CATIONIC LIPIDS - Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids. | 2021-01-14 |
20210009504 | METHODS FOR PRODUCING (6S,15S)-3,8,13,18-TETRAAZAICOSANE-6,15-DIOL - The present invention provides methods of synthesizing (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol and salts thereof. | 2021-01-14 |
20210009505 | CATIONIC LIPIDS AND TRANSFECTION METHODS - The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells. | 2021-01-14 |
20210009506 | P62-ZZ SMALL MOLECULE MODULATORS - A compound, or a pharmaceutically acceptable salt thereof, having a formula I of: | 2021-01-14 |
20210009507 | Synthesis of (2S,3R,4R)-4,5-Dihydroxyisoleucine and Derivatives - The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative. | 2021-01-14 |
20210009508 | Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates - Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification. | 2021-01-14 |
20210009509 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT - The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation. | 2021-01-14 |
20210009510 | CHELATING MOLECULES - Provided herein are a variety of metal chelators as well as methods of use thereof. | 2021-01-14 |
20210009511 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) - A series of phenelzine analogs comprising a phenelzine scaffold linked to an aromatic moiety and their use as inhibitors of lysine-specific demethylase 1 (LSD1) and/or one or more histone deacetylases (HDACs) is provided. The presently disclosed phenelzine analogs exhibit potency and selectivity for LSD1 versus MAO and LSD2 enzymes and exhibit bulk, as well as, gene specific histone methylation changes, anti-proliferative activity in several cancer cell lines, and neuroprotection in response to oxidative stress. Accordingly, the presently disclosed phenelzine analogs can be used to treat diseases, conditions, or disorders related to LSD1 and/or HDACs, including, but not limited to, cancers and neurodegenerative diseases. | 2021-01-14 |
20210009512 | METHOD FOR PRODUCING CARBODIIMIDE COMPOUND - A method for producing a carbodiimide compound, comprising a carbodiimide production step of reacting an aliphatic tertiary isocyanate compound (A) in the presence of an organic alkali metal compound (B) having Lewis basicity. | 2021-01-14 |
20210009513 | CELLULAR TRANSPORT SYSTEM FOR TRANSFERRING A SULFONIC ACID CONSTRUCT CARRYING A CARGO INTO THE CYTOPLASM OF A CELL - The present invention relates to a cellular transport system for bringing a sulfonic acid construct which carries a cargo into a cell and releasing the cargo in the cell's cytoplasm, the cellular transport system comprising: (i) a sulfonate transporter located in the cytoplasm membrane of the cell wherein said sulfonate transporter is capable of transporting said sulfonic acid construct across the cytoplasm membrane into the cytoplasm; (ii) a γ-glutamyl transferase (GGT; EC 2.3.2.2) which is modified to be located in the cytoplasm of the cell, wherein said γ-glutamyl transferase is capable of hydrolyzing said sulfonic acid construct so as to release the cargo. Moreover, the present invention relates to the use of a cellular transport system for bringing a sulfonic acid construct which contains a cargo into a cell and releasing the cargo in the cell's cytoplasm. Further, the present invention relates to a γ-glutamyl transferase for hydrolyzing a sulfonic acid construct which contains a cargo. | 2021-01-14 |
20210009514 | PREPARATION METHOD FOR 4-PHENYLTHIO-BENZENETHIOL - The present disclosure discloses a preparation method for 4-phenylthio-benzenethiol. The preparation method comprises the following steps: subjecting phenyl sulfide as a raw material to a halogenation reaction to obtain 4-halophenyl sulfide; subjecting the 4-halophenyl sulfide to a sulfhydrylation reaction to obtain a 4-phenylthio-phenylthiolate; and subjecting the 4-phenylthio-phenylthiolate to acidification. The preparation method of the present disclosure avoids the use of materials such as thiophenol which pollutes the environment, and realizes efficient recycling of the reaction materials, solvents, water and the like. The preparation method of the present disclosure is a green process for the synthesis of 4-phenylthio-phenylthiol without organic waste, waste acid and waste water discharge. | 2021-01-14 |
20210009515 | ONLINE PRODUCTION OF ORGANIC PEROXIDE USING A CATALYST BED - A method of producing an organic peroxide includes introducing an organic solution and a peroxide solution into a mixing tank to form a mixture. The method further includes circulating the mixture over a fixed catalyst bed to form the organic peroxide and measuring a concentration of the organic peroxide in the mixture. Further, the method includes removing at least a portion of the mixture when the concentration reaches a set value. | 2021-01-14 |
20210009516 | PRODUCTION METHOD OF MALEIMIDE - An object is to provide a method for easily producing maleimide (MI) in which trace amounts of residual acid components as impurities in a crude MI are efficiently reduced, that is, the acid value is sufficiently reduced.
| 2021-01-14 |
20210009517 | ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE - Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided. | 2021-01-14 |
20210009518 | Organic Compound, Light-Emitting Device, Light-Receiving Device, Light-Emitting Apparatus, Light-Emitting Module, Electronic Device, and Lighting Device - An organic compound with high heat resistance is provided. A light-emitting device with high emission efficiency and high reliability is provided. An organic compound represented by General Formula (G0) is provided. In General Formula (G0), any one of R | 2021-01-14 |
20210009519 | HISTONE DEACETYLASE INHIBITORS - Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3). | 2021-01-14 |
20210009520 | HISTONE DEMETHYLASE INHIBITORS - The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like. | 2021-01-14 |
20210009521 | ENANTIOSELECTIVE HYDROGENATION OF 4-SUBSTITUTED 1,2-DIHYDROQUINOLINES IN PRESENCE OF A CHIRAL IRIDIUM CATALYST - The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines comprising enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium (P,N)-ligand catalyst. | 2021-01-14 |
20210009522 | COMPOUNDS FOR INHIBITING LY6K AND METHODS OF USING SAME - The present technology relates to compounds that inhibit human Ly6K and homologs thereof. Also disclosed are methods of using such compounds to: inhibit activity of a Ly6K protein in a cell; decrease migration, colony formation, and/or proliferation of a cell; modulate expression of a gene in a cell, reduce suppression of the immune response to cancer in a subject, decrease tumorigenic growth of a cancer in a subject, and treat or prevent in a subject a disorder mediated by Ly6K protein. | 2021-01-14 |
20210009523 | Compounds and Compositions for the Treatment of Cancer - The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof. | 2021-01-14 |
20210009524 | MCT4 INHIBITORS FOR TREATING DISEASE - Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I | 2021-01-14 |
20210009525 | CRYSTALLINE FORMS OF PLASMA KALLIKREIN INHIBITORS - Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed. | 2021-01-14 |
20210009526 | PROCESSES FOR PREPARING PLASMA KALLIKREIN INHIBITORS - A process for preparing and purifying a compound of Formula I is provided: | 2021-01-14 |
20210009527 | COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME - A compound represented by the following formula (1), wherein X | 2021-01-14 |
20210009528 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR - The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor. | 2021-01-14 |
20210009529 | SULFONYLDIAZOLES AND N-(FLUOROSULFONYL)AZOLES, AND METHODS OF MAKING THE SAME - The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot. | 2021-01-14 |
20210009530 | HERBICIDAL COMPOUNDS - The present invention relates to herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants. | 2021-01-14 |
20210009531 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS - Compounds and methods for treating diseases mediated by a P2X | 2021-01-14 |
20210009532 | PREPARATION METHOD FOR AZOXYSTROBIN AND INTERMEDIATE THEREOF - The present invention relates to the preparation field of azoxystrobin, and discloses a preparation method for a compound represented by formula (I). The method comprises the following steps: (1) a compound represented by formula (II) is hydrolyzed in a solvent under acidic conditions to obtain a compound represented by formula (III); and (2) the compound represented by formula (III) is reacted with a base and a methylating agent to obtain the compound represented by formula (I); in the formula, R | 2021-01-14 |
20210009533 | New Methods for 1,4-Diazo N-Heterocycle Synthesis - The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the compounds made by the novel synthetic method. | 2021-01-14 |
20210009534 | METHOD FOR PRODUCING THE CRYSTALLINE FORM OF MODIFICATION A OF CALCOBUTROL - A method is described for production of a high purity compound of the formula (I) | 2021-01-14 |
20210009535 | OXAZOLE CONTAINING COMPOUNDS AS ACTIVATORS OF IDO1 AND AHR - Provided herein are methods and compositions related to a method of stimulating the immune system in a subject in need thereof by administering an agent that increases the level or activity of indoleamine 2,3-dioxygenase (IDO1) and/or aryl hydrocarbon receptor (Ahr). | 2021-01-14 |
20210009536 | PEPTIDE CONJUGATES OF MICROTUBULE-TARGETING AGENTS AS THERAPEUTICS - The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer. | 2021-01-14 |
20210009537 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME - Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition. | 2021-01-14 |
20210009538 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS - The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: | 2021-01-14 |
20210009539 | 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS - The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: | 2021-01-14 |
20210009540 | 3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS - The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: | 2021-01-14 |
20210009541 | FUNGICIDAL OXADIAZOLES - The present invention relates to oxadiazole derivatives thereof that may be used as fungicides. | 2021-01-14 |
20210009542 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF - Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease. | 2021-01-14 |
20210009543 | BENZAMIDE COMPOUNDS - Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV. | 2021-01-14 |
20210009544 | Method For Preparing Hexahydrofuro-Furanol Derivative, Intermediate Thereof And Preparation Method Thereof - The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivatives and their intermediates. The preparation method is carried out starting from compound Formula A1. | 2021-01-14 |
20210009545 | Functionalized Bifuran and Synthesis Thereof - A 5,5′-Di-(protected)-2,2′-bifuran: | 2021-01-14 |
20210009546 | POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND PHOTORESIST COMPOSITION - A polymerizable compound represented by formula (1). In formula (1), one of eight hydrogen atoms is substituted by a (meth)acryloyloxy group, and the rest seven hydrogen atoms are independently non-substituted or substituted by a saturated hydrocarbon group having 1 to 10 carbons. | 2021-01-14 |
20210009547 | SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS - Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders. | 2021-01-14 |
20210009548 | BURST ATOMIZATION FRACTIONATION SYSTEM, METHOD AND APPARATUS - Systems, methods and apparatus for fractioning mixtures comprising combinations of volatiles, essentially non-volatiles and non-volatile solutes are disclosed. Embodiments of a burst atomization fractionation apparatus comprises an atomization chamber into which a liquid mixture is atomized across a pressure gradient. In various embodiments, a mixture for fractionation comprises mixtures of solvents, solvents and oils, used engine oil, or salt water. In various examples, a solute undergoes a chemical transformation during the fractionation process, such as dehydrogenation, dehydration, or decarboxylation. | 2021-01-14 |
20210009549 | CANNABINOID DERIVATIVES AND CONJUGATES AND USES THEREOF - Cannavinoid derivatives, such as cannabidiol (CBD), desoxy-CBD, and desoxy-Δ | 2021-01-14 |
20210009550 | UREA MOTIF CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS ANTIBACTERIAL DRUGS - The invention relates to compounds which are suitable for treating bacterial diseases and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds and to the use of such compounds as disinfectants. | 2021-01-14 |
20210009551 | COMPOUNDS AND METHODS FOR TREATING FIBROSIS OR CANCER - Provided herein, inter alia, are methods and compounds for treating a pulmonary disease, fibrosis, or cancer. | 2021-01-14 |
20210009552 | METHODS FOR TREATING PROTOZOAN INFECTIONS - The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention. | 2021-01-14 |
20210009553 | PRODUCTION METHOD FOR 1,2,3,5,6-PENTATHIEPANE - The present invention enables provision of a production method for 1,2,3,5,6-pentathiepane, the method comprising, in the following order, step A for reacting a trithiocarbonate, sulfur, and a methane dihalide together using a phase-transfer catalyst in a multilayer system having a water layer and an organic layer, step B for separating the water layer from the organic layer, and step C for stopping the reaction using an acid. | 2021-01-14 |
20210009554 | N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF - The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R | 2021-01-14 |
20210009555 | THERAPEUTIC COMPOUNDS - Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus. | 2021-01-14 |
20210009556 | COMPOUND FOR TREATING CYSTIC FIBROSIS - Provided herein is a compound represented by Formula I: | 2021-01-14 |
20210009557 | ACYCLIC CXCR4 INHIBITORS AND USES THEREOF - The present invention relates to compounds and methods useful for modulation, e.g. inhibition, of C-X-C receptor type 4 (CXCR4). The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the compositions in the treatment of various disorders. | 2021-01-14 |
20210009558 | TARGETING OF ENDOPLASMIC RETICULUM DYSFUNCTION AND PROTEIN FOLDING STRESS TO TREAT NEUROLOGICAL CONDITIONS - Methods and therapeutic compositions are disclosed for treating neurological disorders, such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Parkinson's disease and/or Huntington's disease, using Salubrinal analogs, or pharmaceutically acceptable salts, hydrates, or solvates thereof. | 2021-01-14 |
20210009559 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS - The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein. | 2021-01-14 |
20210009560 | CRYSTALLINE FORMS OF MODULATORS OF CFTR - Crystalline Forms of Compound (I); crystalline Forms of Compound (II) and crystalline forms of pharmaceutically acceptable salts of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. | 2021-01-14 |
20210009561 | HERBICIDAL COMPOUNDS - Compounds of the formula (I) wherein the substituents are as defined in claim | 2021-01-14 |
20210009562 | ANTI-CANCER COMPOUNDS - This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent. | 2021-01-14 |
20210009563 | TREATMENT OF INFECTIOUS DISEASE - The present disclosure relates to 2-(3-indolyl)indolin-3-one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metalocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein said infectious disease is caused by a virus, wherein the virus is from the family flaviviridae or paramyxoviridae. | 2021-01-14 |
20210009564 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF - Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease. | 2021-01-14 |
20210009565 | 2,3-DIHYDRO-ISOINDOLE-1-ONE DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME - The present invention provides a compound selected from the group consisting of a compound of formula (I), pharmaceutically acceptable salts, esters, prodrugs, hydrates, solvates and isomers thereof; a use of the compound for the treatment, relief or prevention of diseases caused by absormal or uncontrolled activation of protein kinase, and a use of the compound for the manufacture of a medicament for the treatment, relief or prevention of the diseases; a pharmaceutical composition comprising the compound as an active ingredient; and a method for the treatment, relief or prevention of the diseases using the compound. The inventive compound is useful for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase. | 2021-01-14 |
20210009566 | PROCESS FOR THE PREPARATION OF PYRIMIDINYL-4-AMINOPYRAZOLE COMPOUNDS - The present disclosure relates to methods of making LRRK2-inhibiting, pyrimidinyl-4-aminopyrazole compounds and intermediates of formulae I and IV: The compounds are useful as LRRK2 inhibitors in the treatment of LRRK2 mediated diseases, and as intermediates for their manufacture. | 2021-01-14 |
20210009567 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS - The present invention encompasses compounds of the formula (I) | 2021-01-14 |
20210009568 | METHODS AND COMPOUNDS FOR TREATING DISORDERS - The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections. | 2021-01-14 |
20210009569 | SYNTHETIC RECEPTORS FOR IONOPHORIC COMPOUNDS - The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds. | 2021-01-14 |
20210009570 | MICRONIZED 1,4-DI(BENZOXAZOL-2'-YL)BENZENE - The present invention relates to a novel micronized 1,4-di(benzoxazol-2′-yl)benzene as well as to the use thereof in topical compositions. | 2021-01-14 |
20210009571 | PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS - The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention. | 2021-01-14 |
20210009572 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND - The present invention provides a compound having a cholinergic muscarinic Ml receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. | 2021-01-14 |
20210009573 | PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES - Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests. | 2021-01-14 |