Class / Patent application number | Description | Number of patent applications / Date published |
702021000 | Cell count or shape or size analysis (e.g., blood cell) | 67 |
20080201083 | Cell Culture Evaluation System, Cell Culture Evaluation Method, and Cell Culture Evaluation Program - There is provided a cell culture evaluation system, a cell culture evaluation method, and a cell culture evaluation program which are capable of estimating and evaluating the lag time or the minimum doubling time and objectively and adequately determining whether or not a cell population is stimulated for proliferation by using an average projected area of a cultured cell population or the rate of increasing the ratio of the non-single-cells as an evaluation parameter when culturing the cells. Images of the cell population to be cultured statically are acquired in a culture vessel, the average projected areas of the cells are calculated from the images for the respective culture times, and the lag times at lag phase are calculated from the calculated average projected areas of the cells. The single-cells and the non-single-cells are discriminated from the images, and the increasing rate of the non-single-cells is calculated from the ratio of the non-single-cells in the cell population to determine the minimum doubling time from the increasing rate of the non-single-cells. Whether or not the cell population is stimulated for proliferation is determined from the ratio of the non-single-cells. | 08-21-2008 |
20080312843 | PROCESS AND SYSTEM FOR ON-LINE AND IN SITU COUNTING OF CELLS IN A BIOLOGICAL CULTURE MEDIUM - A process for on-line and in situ counting of cells in a biological culture medium, comprising the following steps:
| 12-18-2008 |
20080319680 | MULTI-GAIN ADAPTIVE LINEAR PROCESSING AND GATED DIGITAL SYSTEM FOR USE IN FLOW CYTOMETRY - Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range. | 12-25-2008 |
20090006003 | SAMPLE ANALYZER, BLOOD ANALYZER AND DISPLAYING METHOD - The present invention is to present a sample analyzer which is capable of displaying a particle distribution map of a measured sample and a reference particle distribution map so as to be visually compared without reducing a display area for displaying information other than the particle distribution map. The blood analyzer | 01-01-2009 |
20090030620 | System and method for electronic publication of scientific data and analysis - Electronic publication systems are disclosed that enable the analysis and publication of layout files, which contain an analysis strategy and embedded raw data. The published layout files can be accessed by reader applications that are able to read the layout files and modify the analysis strategy within the layout file using the embedded raw data. In many embodiments, the reader applications are unable to access the embedded raw data. In several embodiments, the reader applications prevent the saving or printing of layout files. One embodiment of the invention includes a publication computer connected to a network, a user computer connected to the network and the publication computer is configured to generate a file including an analysis strategy based on the raw data and in which the raw data is embedded. In addition, the publication computer is configured to transfer the file to the user computer, the user computer is configured to receive the file, the user computer is configured to perform modifications of the analysis strategy using the embedded raw data and the user computer is configured to prevent access to the embedded raw data within the file. | 01-29-2009 |
20090076736 | SAMPLE ANALYZER AND COMPUTER PROGRAM PRODUCT - A sample analyzer including a detection unit for irradiating a biological sample with light and obtaining optical information; a cell classification processor for classifying cells contained in the biological sample into cell groups based on the optical information; a scattered light information obtaining processor for obtaining scattered light information relating to a cell included in a predetermined cell group; a calculation processor for calculating a component value corresponding to an amount of component contained in cell included in the predetermined cell group based on the scattered light information; and an output device for outputting the component value calculated by the calculation means is disclosed. A computer program product is also disclosed. | 03-19-2009 |
20090093970 | Automated Sampling And Analysis Using A Personal Sampler Device - The present invention is a system and a method for blood or urine sampling and sample-analysis, through a sampler that is a self blood-testing device or a urine-testing device. The system comprises a sampler, a transmission unit and an analysis unit. A patient may place a sampled blood drops on a sample strip and insert the strip into the sampler. The sampler may automatically prepare the sample and photograph it using a sample-preparation unit and a photography unit respectively. After the sample has been photographed, the resulting sample image may be transmitted to the analysis unit that may analyze the image through an image-processing algorithm. The analysis results may be automatically transmitted to the patient and to a medical authority, such as the patient's physician, a nurse, a clinic and the like, for further analysis, decision-making and treatment. | 04-09-2009 |
20090105963 | Methods for Flow Cytometry Analyses of Un-Lysed Cells from Biological Fluids - A method for analyzing a pathological deviation of at least one white blood cell population from a normal level in an un-lysed blood sample, comprising the steps of counting, with a flow cytometer, a number, n | 04-23-2009 |
20090287421 | Enhancing Flow Cytometry Discrimination with Geometric Transformation - In flow cytometry, particles ( | 11-19-2009 |
20100023274 | Methods and Systems for Transforming Particle Data - In an embodiment, a computer-implemented method is provided for processing data from a particle analyzer. The method includes transforming data using at least one transform that provides: transformation according to a weighted combination of a first mathematical function and a logarithmic function for positive data values, such that the transformation corresponds to the first mathematical function for positive particle data values approaching zero, and to the logarithmic function for positive particle data values approaching infinity; and transformation corresponding to a second mathematical function for negative data values. The transformed data may be then output for display or storage. In another embodiment, the transforming involves substituting the particle data for an independent variable in the transform to directly obtain values to be plotted based on the input particle data values. | 01-28-2010 |
20110054800 | SAMPLE PROCESSING SYSTEM, METHOD FOR SAVING ELECTRICITY CONSUMED BY SAMPLE PROCESSING SYSTEM, AND NON-TRANSITORY STORAGE MEDIUM - A sample processing system is disclosed which comprises at least one processor and at least one memory that stores programs executable collectively by the at least one processor. According to the stored programs, the at least one processor transports sample containers through a conveying path along which there are arranged at least one first module for testing of samples and at least one second module for processing of samples which have been tested by the at least one first module. The at least one second module is switchable between an active state and an inactive state. The at least one processor further obtains a determination result as to whether a sample which has been tested by the at least one first module is necessary to be processed by the at least one second module. If the sample is determined necessary to be processed by the at least one second module, the at least one processor transports a sample container containing the sample to the at least one second module for processing. If the at least one second module is in the inactive state, at least one processor places the at least one second module in the active state to make it ready to process the sample. | 03-03-2011 |
20110071768 | DEVICE FOR ESTIMATING SURVIVAL CELL COUNT, COMPUTER PROGRAM, AND RECORDING MEDIUM - By accurately estimating the survival cell count in a probiotic product, the time for developing the product can be shortened. In a device ( | 03-24-2011 |
20110077871 | ANALYSIS APPARATUS, INFORMATION PROCESSING UNIT, AND AN INFORMATION DISPLAYING METHOD - An analysis apparatus which has a first and second measuring units for measuring a clinical sample; and an information processing unit which is connected to the first and second measuring units so as to perform information communication with the first and second measuring units, wherein the first measuring unit is provided with a first marker, the second measuring unit is provided with a second marker, and the information processing unit has an information display section; and a display controller for displaying the first marker in association with the information relating to the first measuring unit on the information display section, and for displaying the second marker in association with the information relating to the second measuring unit on the information display section. Also, an information processing unit and an information displaying method. | 03-31-2011 |
20110166794 | BLOOD CELL COUNTER, DIAGNOSIS SUPPORT APPARATUS, DIAGNOSIS SUPPORT METHOD AND COMPUTER PROGRAM PRODUCT - A blood cell counter comprising: a detector for detecting blood cells in blood of a subject; and a controller for obtaining, based on a detection result by the detector, first analytical information about hemoglobin amount of red blood cells in the blood and second analytical information about granulocytes in the blood, and for outputting diagnosis support information for supporting determination of whether an inflammatory response of the subject is an infectious inflammatory response or a noninfectious inflammatory response, based on the first analytical information and the second analytical information that have been obtained. A method and computer program product are also disclosed. | 07-07-2011 |
20110295520 | Method and System for Quantitative Cell Nuclei Arrangement Measure in Histological Tissue Using Structural Entropy - A method for measuring structural entropy of cell nuclei in a histological micrograph of a biopsy tissue sample involves the steps of: obtaining a dye color map from a color image of the biopsy tissue sample; locating cell nuclei in the dye color map; and measuring structural features within small groups (cliques or paths) of cell nuclei to determine their degree of organization (or structural entropy). Also, an apparatus for measuring structural entropy of cell nuclei in a histological micrograph of a biopsy tissue sample includes a processor executing instructions for: obtaining a dye color map of the biopsy tissue sample; locating cell nuclei in the dye color map; and measuring structural features within small groups (cliques or paths) of cell nuclei to determine their degree of organization (or structural entropy). | 12-01-2011 |
20110301864 | METHOD OF ASSESSING THE PROLIFERATION OR DIFFERENTIATION BEHAVIOUR OF A POPULATION OF TARGET CELLS IN A BIOLOGICAL SYSTEM - The invention relates to a method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behaviour of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviours, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom. | 12-08-2011 |
20120004859 | USER INTERFACE FOR A FLOW CYTOMETER SYSTEM - A method of extracting and analyzing a data set from a flow cytometer system of the preferred embodiment comprises the steps of (1) running a sample and saving all collected raw data, (2) viewing raw (or “unmodified”) data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified data, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified data, and exporting the saved data as many times as necessary and/or desirable. | 01-05-2012 |
20120010824 | Non-Invasive Method for Assessing Liver Fibrosis Progression - The present invention relates to a non-invasive method for assessing liver fibrosis progression in an individual, said method comprising the steps of calculating the ratio of fibrosis level to cause duration and to a non-invasive method for assessing liver fibrosis progression in an individual, said method comprising the steps of measuring, at two different times t | 01-12-2012 |
20120029833 | ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL AND DEVICES THEREOF - Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis. | 02-02-2012 |
20120041687 | IDENTIFICATION, MONITORING AND TREATMENT OF INFECTIOUS DISEASE AND CHARACTERIZATION OF INFLAMMATORY CONDITIONS RELATED TO INFECTIOUS DISEASE USING GENE EXPRESSION PROFILES - A method is provided in various embodiments for determining a profile data set for a subject with infectious disease or inflammatory conditions related to infectious disease based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 2 constituents from Table 1. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 02-16-2012 |
20120065898 | AUTOMATIC ANALYZER - To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged. | 03-15-2012 |
20120072125 | Assay Device - Disclosed is an assay result reading apparatus, for reading the result of an assay, comprising: a) first and second control thresholds; b) a data processing means for processing an analyte measurement signal indicative of the presence and/or amount of an analyte; and for processing a control signal indicative of whether the assay has been carried out satisfactorily; to: up until a time t | 03-22-2012 |
20120072126 | SYSTEM FOR PROVIDING ANIMAL TEST INFORMATION AND METHOD OF PROVIDING ANIMAL TEST INFORMATION - A system for providing animal test information is disclosed that includes a central device for collecting and processing measurement results acquired by the test devices and connected to test devices for measuring samples obtained from animals. The central device includes an information receiving section for receiving a data set of attribute information and measurement results from each of the test devices. The attribute information received from the test devices indicates animal species or breed of the animal serving as a collecting source of a sample. The central device also includes a data storage for storing a plurality of the data set and an information output section for outputting the measurement results and the attribute information included in the data set stored in the data storage. | 03-22-2012 |
20120078531 | FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING - Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements. | 03-29-2012 |
20120089341 | Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug. | 04-12-2012 |
20120101739 | Chromatogram Display Method, Data Processing Device, and Analysis Device - A novel method for displaying a chromatogram that is capable of displaying a chromatogram with improved visibility is provided. This is a method for displaying a chromatogram having a time axis as a horizontal axis, based on analysis data of a target object in a sample, the method including displaying a chromatogram in which the scale of the time axis for a predetermined time period is altered. | 04-26-2012 |
20120101740 | METHOD, INSTRUMENT AND COMPUTER PROGRAM PRODUCT FOR QUANTIFICATION OF PCR PRODUCTS - This document relates to melting curve analysis of nucleic acids. The method according to first aspect of the invention comprises analyzing a nucleic acid melting curve measured from a sample, the melting curve comprising a sum signal of at least two nucleic acid melt signals and a background signal as a function of temperature. The method further comprises optimizing at least one constant in a temperature-dependent exponential correction function so as to minimize the variation of the nucleic acid melting curve at a temperature region where the target nucleic acids in the sample remain essentially double stranded, and generating a corrected nucleic acid melting curve representative of the nucleic acid melt signal by applying said exponential correction function over the region of the measured melting curve where the strands of the nucleic acids dissociate. According to further aspects, the invention relates to a curve fitting algorithm for precise estimation of melting peak areas and a mathematical transformation for linearization of calibration curve data to enhance the linear measuring range of a competitive PCR assay. The invention provides a powerful tool for analyzing PCR-amplified sample containing two or more different nucleic acids having similar but distinguishable melting temperature. | 04-26-2012 |
20120136584 | DETECTION APPARATUS AND DETECTION METHOD FOR DETECTING MICROORGANISMS - A light receiving element provides a current signal corresponding to an amount of received light scattered by suspended particles moving at a predetermined speed to a pulse width measurement circuit and a current-voltage conversion circuit via a filter circuit. A pulse width measured from the current signal is converted into a voltage value based on a predetermined relationship by a pulse width-voltage conversion circuit, and is provided to a voltage comparison circuit. The current-voltage conversion circuit converts a peak value of the current signal into a voltage value, and an amplifier circuit amplifies the signal at a predetermined amplification factor and provides the same to the voltage comparison circuit. The voltage comparison circuit uses the voltage value converted from the pulse width as a boundary value, and the suspended particles causing the scattered light are detected as microorganisms when the peak voltage value is smaller than the boundary value. | 05-31-2012 |
20120166093 | APPARATUS AND METHOD FOR ANALYZING BACTERIA - An apparatus for analyzing bacteria is described that includes an analytic sample preparation section for preparing an analytic sample by treating a specimen so as to generate a morphological difference between Gram-negative bacteria and Gram-positive bacteria, a detector for detecting optical information from each particle contained in the analytic sample and an analyzing section for detecting Gram-positive bacteria contained on the basis of the detected optical information. A method for analyzing bacteria is also described. | 06-28-2012 |
20120173160 | METHODS AND SYSTEMS FOR QUANTITATIVELY ASSESSING BIOLOGICAL EVENTS USING ENERGY-PAIRED SCORING - Methods for quantitatively assessing the status of a biological event in a testing sample comprise computing a pair-wise energy score for each analyte pair for the biological event based on a testing magnitude value and a relative correlation value for the analyte pair, computing an energy-paired score for the biological event in the testing sample by combining the pair-wise energy score for each analyte pair, and optionally computing a significance level of the energy-paired score. Systems to implement such methods comprise computer readable medium, processors, or hardware to carry out these steps. The energy-paired score provides an estimation of how likely the biological event in the testing sample is up-regulated or down-regulated, which could aid in therapy, drug discovery, prognostic evaluation, or characterization of diseases. | 07-05-2012 |
20120173161 | MEASURING CONTROL METHOD AND ARRANGEMENT - The method is for controlling a measurement process of blood glucose of a patient. At least one repeatedly occurring even is selected within a period of time. A blood glucose measurement difference data is obtained that is associable to the event. Trend data is calculated from the difference data. The measurement process is controlled by using the trend data. Also an arrangement, computer program product and a device are disclosed. | 07-05-2012 |
20120191367 | ASSAY SYSTEMS FOR DETERMINATION OF FETAL COPY NUMBER VARIATION - The present invention provides processes for determining accurate risk probabilities for chromosome dosage abnormalities. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 07-26-2012 |
20120221256 | FUNCTIONAL CHARACTERIZATION OF BIOLOGICAL SAMPLES - The invention relates to systems and methods for characterizing tissue biopsies, cells and organisms as a result of predictable responses to known compounds. A sensor is used to detect plurality of features indicative of physiological activity in response to the external. A vector quantity comprising a number of dimensions equal to a number of different features is derived from the signal output of said sensor array and compared to one or more reference values to generate a physiological ‘fingerprint’. | 08-30-2012 |
20130018596 | METHOD AND DEVICE FOR DETERMINING TARGET BRAIN SEGMENTS IN HUMAN OR ANIMAL BRAINSAANM BOTTGER; JoachimAACI BerlinAACO DEAAGP BOTTGER; Joachim Berlin DEAANM Abbushi; AlexanderAACI BerlinAACO DEAAGP Abbushi; Alexander Berlin DEAANM Margulies; Daniel S.AACI BerlinAACO DEAAGP Margulies; Daniel S. Berlin DE - Method and device for determining target brain segments in human or animal brains | 01-17-2013 |
20130024130 | BLOOD ANALYZER CALIBRATION AND ASSESSMENT - Systems and methods for displaying measured values of a complete blood count (“CBC”) parameter include displaying the measured values of the CBC parameter obtained from a plurality of samples from a first lot of a quality control composition, where the displaying includes displaying a marker corresponding to each measured value from the first lot on a plot that includes a two dimensional coordinate system, and where the two dimensional coordinate system includes a first dimension corresponding to a time at which measured values of the CBC parameter were obtained, and a second dimension corresponding to a numerical value of the CBC parameter. | 01-24-2013 |
20130030715 | APPARATUS AND METHOD FOR MONITORING AUTOTROPH CULTIVATION - A method includes identifying a chlorophyll concentration/optical density (CCpOD) value using a chlorophyll concentration measurement of an autotroph culture and an optical density measurement of the autotroph culture. The method also includes identifying a change in the autotroph culture using the CCpOD value. The change in the autotroph culture can be identified by determining whether the CCpOD value falls outside upper and lower control limits. The upper and lower control limits can be identified using a specified number of previously-determined CCpOD values, which can be calculated when the autotroph culture is in a known healthy state. Multiple CCpOD values can be calculated, and an alarm can be generated if a specified number of the CCpOD values (such as one or more) fall outside the upper and lower control limits. | 01-31-2013 |
20130046482 | SYSTEM AND METHOD FOR ASSOCIATING A MODULI SPACE WITH A MOLECULE - The present invention relates to a system and a method for constructing and associating a moduli space to a molecule or a model of a molecule. This mathematical representation of molecular structures enables the prediction of actual physical molecular structures. Molecular structures can be structures of macromolecules such as protein molecules and protein globules. | 02-21-2013 |
20130080071 | SYSTEMS AND METHODS FOR SAMPLE PROCESSING AND ANALYSIS - Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject. | 03-28-2013 |
20130085682 | MEMORY CARD USAGE WITH BLOOD GLUCOSE DEVICES - A technique and system utilizing a portable memory card in which data for an individual is stored and identified based on a personal identification number or key. With this system, a glucose meter and a health care provider are able to track testing data across multiple meters as well as between various individuals. Moreover, the system is configured to retrospectively collect structured testing data in which, while a structured test may have been intended but the specific questions or data input were not available at the time, the individual is allowed to update the data after the structured testing window. By having the data stored on a portable memory card, the individual is able to keep the data in their possession and also helps with patient confidentiality. | 04-04-2013 |
20130090862 | METHODS AND SYSTEMS FOR ANALYSIS OF PEPTIDE SAMPLE STREAMS USING TANDEM MASS SPECTROSCOPY - The present disclosure relates to methods and systems for analyzing a peptide sample stream from a chromatography column using tandem mass spectroscopy. Analysis of the sample stream during a first time interval is performed in order to identify peptides, such as tryptic peptides, that are contained in the sample stream. Database searching is then performed to identify one or more protein sequences that contain the identified peptide sequence and to identify associated peptide sequences that are contained in the protein sequence that differ from the peptide sequence. The retention time of associated peptides is estimated based on the hydrophobicity of the predicted peptides and by spiking the sample with standard peptides. Information on associated peptides can then be used to configure the mass spectrometer during a second time interval to detect or ignore ions that correspond to the associated peptides. | 04-11-2013 |
20130090863 | Estimation of delta-Cq values with confidence from qPCR data - The invention describes how to estimate delta-Cq values from measured (raw-)Cq values gained from PCR measurements and how to calculate confidence intervals for them. This is realized by the following processing steps: A noise model, which might be constructed on some training PCR data, calculates the distribution of the true target material concentration of a single well for an observed measurement results. Said distribution is calculated for all types of measurement results including “Numeric” raw-Cq values as well as Cq being “Undetected”, which denotes that no fluorescence signal was detected during all cycles and thus corresponds to no or very few target molecules. | 04-11-2013 |
20130096846 | AUTOMATED BLOOD ANALYZER - A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time. | 04-18-2013 |
20130124101 | METHOD FOR DETECTING MAGNETICALLY MARKED OBJECTS AND CORRESPONDING DEVICE - Magnetically marked objects, in particular biological objects, such as cells, are continuously detected by moving at least one magnetically marked object in a magnetic field, measuring a local change in the magnetic field caused by the magnetically marked object, generating a signal, in particular a digitized signal, based on the measured local change in the magnetic field, conditioning the generated signal by at least one convolution of the generated signal using a mathematical function, and evaluating the conditioned signal. The evaluation of the signal includes determining extreme values, in particular maximum values, of the signal and comparing the determined extreme values with a threshold value, in particular a predefined threshold value, which, if exceeded, indicates detection of the object. | 05-16-2013 |
20130131996 | Predictive Test for Selection of Metastatic Breast Cancer Patients for Hormonal and Combination Therapry - A mass-spectral method is disclosed for determining whether breast cancer patient is likely to benefit from a combination treatment in the form of administration of a targeted anti-cancer drug in addition to an endocrine therapy drug. The method obtains a mass spectrum from a blood-based sample from the patient. The spectrum is subject to one or more predefined pre-processing steps. Values of selected features in the spectrum at one or more predefined m/z ranges are obtained. The values are used in a classification algorithm using a training set comprising class-labeled spectra and a class label for the sample is obtained. If the class label is “Poor”, the patient is identified as being likely to benefit from the combination treatment. In a variation, the “Poor” class label predicts whether the patient is unlikely to benefit from endocrine therapy drugs alone, regardless of the patient's HER2 status. | 05-23-2013 |
20130158886 | Accurate Measurement of glutathione for disease diagnosis and drug metabolite screening - A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient. | 06-20-2013 |
20130204538 | SYSTEMS AND USER INTERFACE FOR COLLECTING A DATA SET IN A FLOW CYTOMETER - Systems in a flow cytometer having an interrogation zone and illumination impinging the interrogation zone include: a lens subsystem including a collimating element that collimates light from the interrogation zone, a light dispersion element that disperses collimated light into a light spectrum, and a focusing lens that focuses the light spectrum onto an array of adjacent detection points; a detector array, including semiconductor detector devices, that collectively detects a full spectral range of input light signals, in which each detector device detects a subset spectral range of the full spectral range of light signals; and a user interface that enables a user to create a set of virtual detector channels by grouping detectors in the detector array, such that each virtual detector channel corresponds to a detector group and has a virtual detector channel range including the sum of subset spectral ranges of the detectors in the corresponding detector group. | 08-08-2013 |
20130211731 | MULTI-PATIENT DATA COLLECTION, ANALYSIS AND FEEDBACK - An automated method adapted to monitor and analyze patient data includes: receiving patient data from a set of patient monitoring devices; analyzing the patient data based at least partly on a set of evaluation criteria; and generating multiple status reports, each status report based at least partly on the analysis of patient data. A system adapted to collect and analyze patient data includes: multiple measurement devices, each device associated with a particular patient; a server device adapted to receive data from at least one of the measurement devices; and a storage adapted to store the received data. An automated method adapted to evaluate quality of care of patients having a chronic condition includes: receiving patient data; receiving a set of performance metrics; receiving a set of operating procedures; and generating a set of reports based at least partly on an evaluation of the patient data, performance metrics and operating procedures. | 08-15-2013 |
20130245963 | SIMPLIFYING RESIDUE RELATIONSHIPS IN PROTEIN DESIGN - The invention provides a method of determining changes in a first set of residues r | 09-19-2013 |
20130282300 | Combined Spectroscopic Method for Rapid Differentiation of Biological Samples - A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class. | 10-24-2013 |
20130282301 | Closed Loop Blood Glucose Control Algorithm Analysis - Methods and devices to generate a tool for testing, simulating and/or modifying a closed loop control algorithm are provided. Embodiments include receiving glucose data for a predetermined time period, determining a variation in the glucose level based on the received glucose data, filtering a received glucose data based on the determined variation, substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition. | 10-24-2013 |
20130282302 | Method and System for Providing Real Time Analyte Sensor Calibration with Retrospective Backfill - Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data. | 10-24-2013 |
20130297222 | METHOD AND APPARATUS FOR ANALYTE MEASUREMENTS USING CALIBRATION SETS - Examples of methods and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. In one example, the method can reduce the error in the estimation of analyte concentration in the presence of interferents. The method can include the use of one or more calibration set to determine analyte concentration. From a sample measurement, each calibration set can be tested to determine if it is eligible to estimate the analyte concentration in the sample. An estimate of analyte concentration can then be produced, based at least in part on the eligible calibration sets and on the sample measurement. In some implementations, if no calibration sets are eligible, an action is taken such as not outputting an estimate, displaying an alarm or alert, or providing a notification. | 11-07-2013 |
20130297223 | Detection Device for Detecting a Blood Picture Parameter - A detection device for detecting a blood count parameter of a blood component in a blood vessel comprising a transmitter, a receiver, a loss detector, and a processor. The transmitter injects a first transmit signal into the blood vessel at a first frequency and a second transmit signal into the blood vessel at a second frequency. The receiver receives a first receive signal at the first frequency and a second receive signal at the second frequency. The loss detector determines a first loss value on the basis of the first transmit signal and the first receive signal, and determines a second loss value on the basis of the second transmit signal and the second receive signal. The processor determines a relaxation time constant of the blood component in accordance with the frequency having the greater loss value, and determines the blood count parameter in accordance with the determined relaxation time constant. | 11-07-2013 |
20130297224 | Method for evaluating a set of measurement data from an oral glucose tolerance test - A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures. The method also may include evaluating the position of the point with respect to reference points, which each represent a defined state of health, in order to calculate a parameter that specifies the state of the glucose metabolism of the patient. | 11-07-2013 |
20130345989 | METHOD AND DEVICE FOR COUNTING PARTICLES IN LIQUID - For a blood cell measuring part replaceably formed as a cartridge, a threshold value for determining particles is adjusted utilizing a specific parameter that observably varies according to the cross-sectional area of the aperture for use. In a first embodiment, the volume of the smallest frequency in the obtained volume-frequency distribution is used as a threshold value K | 12-26-2013 |
20140012514 | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents - A testing method for identification whether a cancer patient is a member of a group or class of cancer patients that are not likely to benefit from administration of a platinum-based chemotherapy agent, e.g., cisplatin, carboplatin or analogs thereof, either alone or in combination with other non-platinum chemotherapy agents, e.g., gemcitabine and paclitaxel. This identification can be made in advance of treatment. The method uses a mass spectrometer obtaining a mass spectrum of a blood-based sample from the patient, and a computer operating as a classifier and using a stored training set comprising class-labeled spectra from other cancer patients. | 01-09-2014 |
20140032127 | SPECTROSCOPIC FINGER-PRINTING OF RAW MATERIALS - The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation. | 01-30-2014 |
20140032128 | SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND DETERMINING CHROMOSOME COPY NUMBER - Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. | 01-30-2014 |
20140172321 | LEUKEMIA CLASSIFICATION USING CPD DATA - Embodiments of the present invention encompass automated systems and methods for predicting an acute leukemia sub-type of an individual diagnosed with acute leukemia based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an acute leukemic sub-type of the individual. | 06-19-2014 |
20140297200 | CELL ANALYZER, CELL COLLECTING APPARATUS, AND QUALITY CONTROL METHOD - Disclosed is a cell analyzer comprising: a measuring device that includes a collecting section configured to collect target cells in a specimen with a filter, and is configured to measure the target cells collected by the collecting section; and a data processing device configured to analyze the target cells based on measurement data obtained by the measuring device, wherein the cell analyzer is operable in a first mode of measuring a clinical specimen collected from a subject and a second mode of measuring a quality control specimen containing particles having size capturable by the filter; and the data processing device is programmed to acquire an amount of particles collected by the collecting section based on measurement data of the quality control specimen obtained in the second mode, and output an alarm when the amount of particles meets a predetermined condition. | 10-02-2014 |
20140343869 | PARTICLE PROCESSING SYSTEMS AND METHODS FOR NORMALIZATION/CALIBRATION OF SAME - Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard. | 11-20-2014 |
20150019140 | DIELECTRIC SPECTROSCOPY METHODS AND APPARATUS - Methods and apparatus are disclosed for correcting measurements received by applying a frequency-varying signal with a measuring device (e.g., a permittivity probe) to a population of living cells (e.g., contained in a bioreactor) and correcting measurement divergences using data acquired using an alternate analytical method (e.g., trypan blue exclusion). In one example, a method comprises receiving electrical property data for a first population of cells, the data obtained by applying a first frequency-varying signal to the population with a measuring device, receiving biological property data obtained using an alternate analytical technique, generating at least one value representative of the frequency dependence of the electrical property data, and determining a relationship between the biological property data and the representative value. In some examples, measurements of apoptosis are predicted using the electrical property data. | 01-15-2015 |
20160018355 | Normalized Calibration Of Analyte Concentration Determinations - Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations. | 01-21-2016 |
20160033537 | Progressive Approximation of Sample Analyte Concentration - Error may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The closer the analysis-determined pseudo-reference analyte concentration is to the reference analyte concentration of the test sample, the more accurate and/or precise the analyte concentration determined by the measurement device using an anchor parameter during compensation. The present invention provides an improvement in the accuracy and/or precision of the analysis determined pseudo-reference concentration through progressive approximation. | 02-04-2016 |
20160103143 | METHODS AND SYSTEM FOR USE IN NEONATAL DIAGNOSTICS - The present invention concerns methods and tools for analysing biomarkers useful for diagnosing an individual, in particular a newborn, with a respiratory disease, especially a newborn suffering from respiratory distress syndrome (RDS). The method and tools of the invention can in one embodiment be used for very rapidly detecting the ratio between lecithin and sphingomyelin in very small body fluid samples, e.g. gastric aspirate of a newborn. The invention is thus useful for obtaining a rapid treatment of RDS by administration of surfactant. | 04-14-2016 |
20160139041 | SYSTEMS AND METHODS FOR COLLISION COMPUTING FOR DETECTION AND NONINVASIVE MEASUREMENT OF BLOOD GLUCOSE AND OTHER SUBSTANCES AND EVENTS - A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances. | 05-19-2016 |
20160147937 | APPARATUS AND METHOD FOR COUNTING ALLELES - An apparatus and method for counting alleles are disclosed herein. The apparatus for counting alleles includes a file input unit and a counting unit. The file input unit receives one or more files including human genome data. The counting unit reads the files on a predetermined window size basis by means of parallel reading using multi-threading based on the position information of the files, performs allele counting, and merges the results of the counting. | 05-26-2016 |