| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 623200420 | Specific material for heart valve | 18 |
| 20090043383 | GENETICALLY MODIFIED HEART VALVE XENOGRAFTS - The invention relates to heart valve xenografts from transgenic pigs having a disruption of an α1-3 galactosyl transferase nucleic acid sequence and use of the xenografts for treating a patient. | 02-12-2009 |
| 20090048669 | METHODS AND SYSTEMS FOR MODIFYING VASCULAR VALVES - Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa. | 02-19-2009 |
| 20090054977 | AMORPHOUS METAL ALLOY MEDICAL DEVICES - This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. | 02-26-2009 |
| 20090125104 | Monocusp Valve Design - The disclosure relates to implantable prosthetic valves comprising support frames. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members. | 05-14-2009 |
| 20090222085 | Cellulose Based Heart Valve Prosthesis - Disclosed are cellulose-based pliable, porous and non-porous prosthesis structures that can be formed to various geometries such as thin films, membranes, hollow tubes, heart valves, including an aortic heart valve. Also disclosed are methods for preparing a cellulose-based porous prosthesis structure. | 09-03-2009 |
| 20100145441 | THERAPEUTIC AGENTS FOR ANGIOGENESIS-RELATED DISEASES COMPRISING CHONDROMODULIN-I AS ACTIVE INGREDIENT - An objective of the present invention is to analyze the function of anti-angiogenic factors in cardiac valves or such to elucidate the developmental mechanism of angiogenesis-induced diseases. A more specific objective is to provide therapeutic agents for angiogenesis-induced diseases such as valvular heart disease, and methods of efficiently screening for the therapeutic agents. The present inventors discovered that chondromodulin-I was markedly expressed in cardiac valves, and plays an important role in maintaining normal functions of the valves by preventing angiogenesis, thickening, and calcification which lead to valvular heart diseases. Chondromodulin-I proteins and substances that activate the expression or function of the proteins are expected to have therapeutic effects against angiogenesis-induced diseases. | 06-10-2010 |
| 20110093066 | Degradable Biocompatible Block Copolymer - Disclosed is a biocompatible block copolymer containing the polycondensation product of a diol and an additional component selected from the group of the same diol, an α,ω-dihydroxy-polyester or an α,ω-dihydroxy-polyether. Also disclosed are a medical implant containing the block copolymer, the use of said block copolymer for the production of a medical implant, a diol and a method for the production thereof. The diol may be obtained by transesterification of α,ω-dihydroxy-[(oligo(3-(R)-hydroxybutyrate)-ethylene-oligo-(3-(R)-hydroxybutyrate)] with diglycolide. Transesterification is carried out, preferably, in the presence of a catalyst. | 04-21-2011 |
| 20110208299 | IMPLANTABLE VALVE PROSTHESIS AND METHOD FOR MANUFACTURING SUCH A VALVE - The invention relates to an implantable valve prosthesis, optionally comprising a support structure and at least one valve leaflet. The valve prosthesis comprises a material structure of unidirectional reinforcing elements of drawn ultra high molecular weight polyolefin, extending in at least two directions, wherein the modulus of elasticity of the polyolefin reinforcing elements is at least 60 GPa. The invention furthermore relates to a method for manufacturing such an implantable valve. The valve is easily manufactured and has an improved durability. | 08-25-2011 |
| 20120290083 | VALVE FOR A HEART VALVE PROSTHESIS - A valve for a heart valve prosthesis comprising a valve membrane composed of at least one spiral strip which, in the closed state of the valve membrane, assumes the form of an Archimedean spiral, wherein the outer edge regions of the spiral strip overlap an inner edge region of the spiral strip of a previous winding of the spiral. | 11-15-2012 |
| 20140012374 | INTRA-ANNULAR MOUNTING FRAME FOR AORTIC VALVE REPAIR - An intra-annular mounting frame for an aortic valve having native aortic cusps is provided which includes a frame body with native leaflet reorienting curvatures and interconnecting points; the curvatures shaped to be received inside the valve below the native aortic cusps and to reorient the native aortic cusps within the aortic valve, where each of the curvatures extends concavely upward from a reference latitudinal plane tangential to each curvature's base. | 01-09-2014 |
| 20140163673 | PROSTHETIC HEART VALVE LEAFLET ADAPTED FOR EXTERNAL IMAGING - Embodiments provided herein are related to prosthetic heart valve leaflets comprising one or more imageable elements that allow for visualization of the movement of the leaflets using imaging techniques, such as, but not limited to fluoroscopy, x-ray, ultrasound, and MRI. When visualized using visualization techniques, the movement of the imageable element is directly related to the movement of the leaflet to which it is coupled, and therefore the movement of the leaflet may be determined. | 06-12-2014 |
| 20140277428 | Thermally-Activated Biocompatible Foam Occlusion Device for Self-Expanding Heart Valves - A structure for sealing a gap between a medical device and adjacent body tissue includes a ring-shaped body formed at least in part of a material that expands from a compressed condition to an expanded condition when heated to a transition temperature and that is adapted to conform to the body tissue in the expanded condition. | 09-18-2014 |
| 20140350671 | BIOMEDICAL IMPLANT FOR USE IN FLUID SHEAR STRESS ENVIRONMENTS - The present invention relates to a biomedical implant for use in a fluid shear stress environment of a subject. The biomedical implant of the present invention includes a patterned surface having a plurality of cellular niches. The cellular niches of the patterned surface are effective to maintain at least one localized layer of living cells within the plurality of cellular niches by decreasing fluid shear stress within the cellular niches as compared to fluid shear stress measured outside of the cellular niches, with the fluid shear stress measured outside of the cellular niches having a peak fluid shear stress of at least about 50 dynes per square centimeter (dynes/cm | 11-27-2014 |
| 20150018944 | Valve Positioning Device - Medical devices for positioning a valve in a subject's body, such as a prosthetic heart valve in a subject's heart, are disclosed. The prosthetic heart valve may include a valve assembly, a frame, and a control arm. The prosthetic heart valve may include a commissural post or multiple commissural posts. The prosthetic heart valve may include a positional marker on a control arm. The prosthetic heart valve may include multiple positional markers on one or more control arms. The positional markers can be shapes, characters, or other symbols. The positional markers may themselves be asymmetric. The positional markers may be placed in an asymmetric location on a control arm. The control arm may be asymmetrically shaped. | 01-15-2015 |
| 20150314042 | BIOPROSTHETIC TISSUE HAVING A REDUCED PROPENSITY FOR IN VIVO CALCIFICATION - A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant. | 11-05-2015 |
| 20150352263 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE - The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ. | 12-10-2015 |
| 20160030165 | Means for Controlled Sealing of Endovascular Devices - Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated. | 02-04-2016 |
| 20160199179 | Production Of Tissue Engineered Heart Valves | 07-14-2016 |
