| Entries |
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| 20080200948 | NOVEL BIOMATERIALS AND A METHOD FOR MAKING AND USING SAME - Novel biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material. | 08-21-2008 |
| 20080208250 | Disposable chemiluminescent infrared therapy device - A therapeutic device has a first chamber that retains an oxalic ester solution, and a second chamber that retains a hydrogen peroxide and fluorescer solution. The therapeutic device is activated by causing the oxalic ester solution to mix with the hydrogen peroxide and fluorescer solution, which produces chemiluminescent light for treating a wound. | 08-28-2008 |
| 20080215088 | Systems, Methods, and compositions for achieving closure of suture sites - Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure. | 09-04-2008 |
| 20080221616 | INTEGRATED VASCULAR DEVICE WITH PUNCTURE SITE CLOSURE COMPONENT AND SEALANT AND METHODS OF USE - Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an integrated vascular device having a sheath with a closure component and puncture sealant. The closure component is disposed on and advanceable over the exterior of the sheath and may comprise any of a variety of apparatus suited for closing a vascular puncture. Once the closure component has been actuated to close the puncture, sealant is introduced to seal the puncture. The sheath and closure component are then removed from the patient. | 09-11-2008 |
| 20080255610 | Adhesive-Containing Wound Closure Device and Method - An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition. | 10-16-2008 |
| 20080281352 | Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers - One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema. | 11-13-2008 |
| 20080287987 | Dispensing system for tissue sealants - The present invention discloses a medical device comprising a dispenser adapted to dispense a tissue sealant or one or more precursor compounds, the dispenser being operably coupled to a surgical stapler, which in turn is configured to deliver one or more surgical staples or fasteners in an area of bodily tissue approximation surface. Furthermore, the medical device comprises a dispenser adapted to dispense a tissue sealant or one or more precursor compounds thereof, the dispenser being operably coupled to a surgical cutter. Additionally or alternatively the medical; device can include a microactuation mechanism, whereby the dispenser dispenses the tissue sealant or one or more precursor compounds at a surgical cutting site or in a proximity thereof. | 11-20-2008 |
| 20090018575 | TISSUE-ADHESIVE FORMULATIONS - A tissue-adhesive formulation comprises a particulate material having tissue-reactive functional groups, in admixture with a particulate buffer material. The formulation is preferably free or substantially free of materials of human or animal origin. In preferred embodiments, the formulation consists, or consists essentially of, an anhydrous or partially hydrated blend of particulate material having tissue-reactive functional groups and particulate buffer material. Also disclosed is a multilayer sheet comprising a structural support coated on at least one side thereof with such a tissue-adhesive formulation. | 01-15-2009 |
| 20090030451 | Synthetic Sealants - A biocompatible synthetic macromer composition is provided which includes a first polymer having stiffening linkages and at least one amine group, and a second component having at least one amine-reactive group. The biocompatible synthetic macromer composition can be used as an adhesive or sealant in human and/or animal medical applications. | 01-29-2009 |
| 20090036921 | Controlled Viscosity Tissue Adhesive - Disclosed are methods and compositions for closing and sealing a wound, laceration, incision, or other percutaneous opening using an adhesive. In one preferred embodiment, the sides of the percutaneous opening are brought together in apposition and the adhesive is applied topically over the apposed opening and the skin adjacent thereto. Adhesives used in the methods of the preferred embodiments exhibit sufficient viscosity to substantially prevent flow of the adhesive into the percutaneous opening. Adhesives may also be used in surgical applications, as a covering for a trauma to the outer surface of the skin, or as a secondary means of closure in combination with other means of closure, including staples and sutures. In a preferred embodiment, the adhesive is a adhesive comprising cyanoacrylate monomer, cyanoacrylate polymer, and a plasticizer. | 02-05-2009 |
| 20090062849 | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells - A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound. | 03-05-2009 |
| 20090099595 | Method and mixture for treating unilateral vocal fold paralysis - The present invention provides methods and mixtures for treating unilateral vocal fold paralysis (UVFP) and/or enhancing functional recovery of a damaged recurrent laryngeal nerve (RLN). The method of the present invention comprises applying a fibrin glue mixture to a portion of laryngeal muscle. The fibrin glue mixture comprises a growth factor, fibrinogen, aprotinin and divalent calcium ion. | 04-16-2009 |
| 20090112255 | SPRAY DEVICES AND METHODS - Some embodiments of a spray device can be configured to maintain a viscous fluid in isolation from a propellant fluid until after the viscous fluid exits from a nozzle of the spray device. For example, the viscous fluid may comprise an adhesive such a surgical adhesive. When the spray device is actuated, the surgical adhesive can exit the nozzle whereat the propellant fluid acts upon the surgical adhesive to break it into droplets for application on a targeted site. | 04-30-2009 |
| 20090112256 | Suturing device with tissue sealant dispenser - The present invention discloses a medical device comprising a dispenser adapted to dispense a tissue sealant or one or more precursor compounds, the dispenser being operably coupled to a surgical suturing device, which in turn is configured to deliver one or more surgical sutures or fasteners in an area of bodily tissue approximation surface. Furthermore, the medical device comprises a dispenser adapted to dispense a tissue sealant or one or more precursor compounds thereof, the dispenser being operably coupled to a surgical cutter. Additionally or alternatively the medical; device can include a microactuation mechanism, whereby the dispenser dispenses the tissue sealant or one or more precursor compounds at a surgical cutting site or in a proximity thereof. | 04-30-2009 |
| 20090125057 | Fan-Shaped Cannula For Sealing Ophthalmic Incisions - A device for delivering an incision sealant includes a housing, a seal, and a cannula. The housing at least partially encloses a chamber that holds a quantity of a sealant. The seal is located on one end of the housing and contains the sealant in the chamber. Likewise, a similar seal may be located at the tip end of the fan-shaped cannula. The cannula is fluidly coupled to the chamber, is disposed along an axis, and has a generally fan-shaped end. The generally fan-shaped end has a top surface and an opening for dispensing the sealant. The shape of the generally fan-shaped end is configured to apply sealant to an incision geometry or to conform to the geometry of an eye. | 05-14-2009 |
| 20090143816 | Grasper with surgical sealant dispenser - The present disclosure is directed to a medical device comprising a dispenser adapted to dispense a tissue sealant or one or more precursor compounds, the dispenser being operably coupled to a grasper. Furthermore, the medical device comprises a dispenser adapted to dispense a tissue sealant or one or more precursor compounds thereof, the dispenser being operably coupled to a surgical cutter. Additionally or alternatively the medical device can include an actuation mechanism, whereby the dispenser dispenses the tissue sealant or one or more precursor compounds at a surgical cutting site or in a proximity thereof. | 06-04-2009 |
| 20090177226 | Bioabsorbable Surgical Compositions - Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications. | 07-09-2009 |
| 20090210002 | METHOD OF FORMING A CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL - Liquid hemostatic coating materials comprise a cyanoacrylate monomer and a solvent system comprising a volatile, non-reactive liquid that is non-stinging and non-irritating to a user. The material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface. | 08-20-2009 |
| 20090222037 | ULTRASONIC VASCULAR CLOSURE DEVICE - The present invention relates to the use of a low frequency ultrasonic device for the delivery and activation of collagen based foam sealants to a human and/or animal patient for sealing puncture wounds in vascular tissues. The ultrasonic vascular closure device comprises an ultrasonic generator, an ultrasound transducer, a chamber containing a foam sealant, a transducer tip, a radiation surface, an orifice located at the distal end of the chamber. The foam sealant is ejected into a puncture wound and activated with ultrasonic waves emitting from the radiation surface. The ultrasonic waves induce vibrations within the foam sealant, slightly warming the foam sealants to assist the rapid sealing the puncture. The ultrasonic waves also provide and anesthetic effect for the pain and discomfort from the puncture site. | 09-03-2009 |
| 20090222038 | MEDICALLY ACCEPTABLE FORMULATION OF A DIISOCYANATE TERMINATED MACROMER FOR USE AS AN INTERNAL ADHESIVE OR SEALANT - The present invention is directed to a medically acceptable formulation comprising a diisocyanate terminated macromer or mixture thereof, and bio-absorbable desiccant comprising a hygroscopic and/or hydrophilic or combination thereof. The present invention is also directed to methods of use for such formulations for medical procedures. | 09-03-2009 |
| 20090264921 | ADHESIVE HEMOSTATIC AGENT BASED ON PORCINE ATELOCOLLAGEN AND METHOD FOR PRODUCTION THEREOF - Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers. The agent includes an antifibrinolytic agent in addition to an esterified atelocollagen which is non-immunogenic and may become positively charged thereon such that the adhesive hemostatic agent has no possibility of mediating particular diseases or viral infections (HIV, HCV, HBV, CMV, etc), unlike conventional agents comprising blood constituents, and readily binds to negatively charged platelets at high adhesive strength, thus inducing quick blood coagulation. Also, provided is a method for preparing the same. | 10-22-2009 |
| 20090281566 | BODILY SEALANTS AND METHODS AND APPARATUS FOR IMAGE-GUIDED DELIVERY OF SAME - Generally, systems, methods, and apparatus related to the use of a dynamic imaging modality in an image guided intervention are disclosed herein. More specifically, the use of such modalities in sealing a bodily opening, such as those that may be formed during an invasive medical procedure are disclosed herein. In some embodiments, a method includes viewing a representation of an instrument within a body of a patient, adjusting a position of the instrument based on the viewing such that a portion of the instrument is at a location within the body of the patient, and delivering a sealant via the instrument to the location within the body of the patient. The sealant is configured to seal an opening in the body part. | 11-12-2009 |
| 20090306707 | Joining and/or Sealing Tissues Through Photo-Activated Cross-Linking of Matrix Proteins - A method of joining and/or scaling tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex: thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion. | 12-10-2009 |
| 20100004682 | SYSTEM FOR TREATING SKIN WOUNDS, BANDAGING AND BIOCHEMICAL ACTIVATION EQUIPMENT FOR EMPLOYING THIS SYSTEM - The present invention concerns a system for dermatologic treatment comprising an energy source for activating a biochemical healing effect and at least one bandage meant to be placed on or near the area being treated before applying the activation step using the said energy source characterized in that the bandage comprises an identification means ( | 01-07-2010 |
| 20100010536 | ADHESIVE COMPOSITIONS FOR USE IN SURGICAL THERAPY - An adhesive composition for use in surgical therapy includes at least the following components a) and b): a) a liquid mixture including cyanoactrylate monomers and at least one plasticizer, where the proportion of the at least one plasticizer in component a) is greater than 10% by weight based on the total weight of component a), and b) an aqueous liquid including at least one compound from the group of borate salt, basic amino acid, gelatin and gelatin derivative. | 01-14-2010 |
| 20100030258 | Controlled Exotherm of Cyanoacrylate Formulations - An adhesive composition includes one or more polymerizable cyanoacrylate monomers, a polymerization initiator and a polymerization accelerator for the one or more polymerizable cyanoacrylate monomers. A system for treating living tissue includes a first reservoir containing one or more polymerizable cyanoacrylate monomers, a second reservoir in a non-contacting relationship with the first reservoir containing a polymerization initiator and accelerator for the one or more polymerizable cyanoacrylate monomers, and an applicator capable of combining the polymerizable cyanoacrylate monomer and the polymerization initiator and accelerator to form an adhesive composition and then applying the adhesive composition to living tissue. The initiator may be a quaternary ammonium salt, and the accelerator may be a trihydroxy tertiary amine. | 02-04-2010 |
| 20100057122 | SPRAY FOR FLUENT MATERIALS - Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees. | 03-04-2010 |
| 20100063539 | Acellular Matrix Glue - An acellular matrix glue and a method of making is disclosed. Specifically, an acellular matrix glue that is useful in preparing a reinforced acellular matrix for medical applications including tissue engineering and hernia repair. | 03-11-2010 |
| 20100076486 | DISC ANNULUS CLOSURE - Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses. | 03-25-2010 |
| 20100100124 | BIOABSORBABLE SURGICAL COMPOSITION - Compounds are provided which can form bioabsorbable compositions useful as adhesives and/or sealants for medical/surgical applications. | 04-22-2010 |
| 20100114158 | DELIVERY ASSEMBLY, DELIVERY TIP, AND METHOD OF USING SAME - Embodiments of a delivery device, a kit comprising the delivery device, and methods of using the same are presented. In one embodiment, the delivery device includes a syringe assembly defining two or more reservoirs each configured to hold a dispensable material. Additionally, the delivery device may include a delivery tip. The delivery tip may have an inlet, an outlet, a central flow-restricting portion, and one or more channels adjacent to the central flow-restricting portion that provide fluid communication between the inlet and the outlet, the one or more channels including a section that tapers inwardly toward the outlet. In one embodiment, the delivery device is configured such that if the two or more reservoirs hold dispensable material then the syringe assembly can be actuated to dispense the dispensable material from the two or more reservoirs substantially simultaneously into the inlet. | 05-06-2010 |
| 20100160960 | HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME - A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant. | 06-24-2010 |
| 20100191281 | Apparatus and Method for Delivering a Biocompatible Material to a Surgical Site - A device for delivering a biocompatible material to a surgical site includes a cannula having proximal and distal portions and at least a first interior lumen disposed therebetween through which the biocompatible material is delivered. The device further includes an initiation member for initiating cross-linking of the biocompatible material while the biocompatible material is within the cannula. The cannula may include a heating element to thermally initiate cross-linking. Alternately, the cannula may include a second lumen for transmitting light from a light source. A movable blocking element controls the amount of light that passes into the first lumen. A method of delivering a curable biocompatible material to a surgical site includes positioning a distal portion of a cannula adjacent the surgical site and introducing the biocompatible material through a first lumen of the cannula. Cross-linking of the biocompatible material is then initiated while the biocompatible material is within the cannula. | 07-29-2010 |
| 20100198255 | SPRAY HEAD, AND APPARATUS AND METHOD FOR APPLYING BIOLOGICAL TISSUE ADHESIVE - A spray head ( | 08-05-2010 |
| 20100241163 | Aortic Dissection Treatment System and Method of Use - An aortic dissection treatment system and method of use including a treatment system for an aortic dissection having a catheter defining a suction lumen and a sealant lumen; a flexible cup defining an isolation region within the flexible cup, the isolation region being in communication with the suction lumen and the sealant lumen; and a sealant fluid deliverable to the aortic dissection through the sealant lumen and the isolation region. The flexible cup is sized to fit over at least one end of the aortic dissection and the suction lumen applies suction to maintain the flexible cup over the at least one end of the aortic dissection. | 09-23-2010 |
| 20100280547 | Applicator System for the Delivery of Surgical Sealants - One aspect of the invention relates to a simple, inexpensive applicator system which can be used for the delivery of a hydrogel formulation. In certain embodiments, the applicator system is suitable for use in sealing of dura mater, especially dura matter within the spinal column. In other embodiments, the applicator system may be used to repair cardiovascular defects, defects of the gall or urinary bladder, or repair of any of the other ducts within the body. | 11-04-2010 |
| 20100312273 | COMBINED VASCULAR AND CLOSURE SHEATH - The technology described herein provides an apparatus and associated methods for the rapid percutaneous occlusion of a vascular access site. In one exemplary embodiment, a combined vascular and closure sheath is provided. This device includes a vascular sheath having a vascular sheath lumen, a proximal end and a distal end, and an exterior surface. The combined vascular and closure sheath includes a closure sheath, being lesser in length and greater in diameter than the vascular sheath and having a proximal end and a distal end, disposed circumferentially around the exterior surface of the vascular sheath at the proximal end of the vascular sheath, thereby forming a closure sheath lumen between the exterior surface of the vascular sheath and an interior surface of the closure sheath, the closure sheath being configured operably to eject a fluid such as a coagulant, a tissue sealant, and the coagulation protein thrombin. | 12-09-2010 |
| 20100312274 | DEVICE FOR THE APPLICATION OF FIBRIN ADHESIVE - A device for the application of two components of fibrin adhesive at a treatment site comprising a support for syringes comprising two parallel cylindrical housings to receive corresponding syringes and a plunger connecting member, characterised in that the said syringe support comprises a passage for insertion of the said plunger connecting member, the said passage being located in the space defined between the cylindrical housings of the said syringe support, the said plunger connector having a zone with a suitable geometry to slide within the said passage and in that the transverse cross-section of the said passage of the syringe support has a maximum opening at the ends and a minimum opening in the central part. | 12-09-2010 |
| 20110004240 | VISIBLE LIGHT CURABLE ADHESIVE - An object of the present invention is to provide a water soluble bioadhesive that is curable by visible light irradiation. The present invention provides a visible light curable adhesive, which comprises a water soluble oxygen sensitizer that generates radicals under visible light irradiation and a water soluble polymer compound having a functional group that can be activated via singlet oxygen generated from the oxygen sensitizer under visible light irradiation. | 01-06-2011 |
| 20110004241 | ADHESIVE - Methods comprising: providing a migrate-sensitive substrate having a surface to be bonded; providing an adhesive formulation comprising an isocyanate-terminated polyurethane prepolymer containing one or more tertiary amino groups; and forming a migrate-free adhesive bond between the surface of the migrate-sensitive substrate and a second surface; as well as adhesive formulations comprising an isocyanate-terminated polyurethane prepolymer containing one or more tertiary amino groups; and wound closure systems comprising such an adhesive formulation. | 01-06-2011 |
| 20110022082 | Wound Closing Device | 01-27-2011 |
| 20110034954 | SUTURELESS REINFORCEMENT FOR AND METHOD OF TREATING A MYOCARDIAL INFARCTION - A method of treating a heart condition includes dispensing first and second sealant components to a myocardial infarction via an introducer extending through a percutaneous puncture in a subxiphoid region. The first and second sealant components combine to form a medical sealant material that bonds to the myocardial infarction to form a reinforcement for the myocardial infarction, wherein the reinforcement does not include a patch. | 02-10-2011 |
| 20110040323 | COMBINATION FOR AN ADHESIVE BONDING OF BIOLOGICAL TISSUES - The present invention relates to a combination, in particular for the adhesive bonding and/or fixing of biological and/or synthetic tissues, wherein the combination comprises the components
| 02-17-2011 |
| 20110066182 | Tissue Sealant for Use in Non Compressible Hemorrhage - ClotFoam is a surgical sealant and hemostatic agent designed to be used in cases of non-compressible hemorrhage. It can be applied in the operating room through laparoscopic ports, or directly over lacerated tissue in laparotomy procedures or outside the operating room through a mixing needle and/or a spray injection method following abdominal, chest, extremities or other intracavitary severe trauma to promote hemostasis. Its crosslinking technology generates an adhesive three-dimensional polymeric network or scaffold that carries a fibrin sealant required for hemostasis. When mixed, Clotfoam produces a foam that spreads throughout a body cavity reaching the lacerated tissue to seal tissue and promote the coagulation cascade. | 03-17-2011 |
| 20110066183 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 03-17-2011 |
| 20110077684 | NUCLEUS REPLACEMENT BASED ON INJECTABLE PVA GELS - The invention relates to novel polyvinyl alcohol (PVA) gels which gelate in situ and are suitable for nucleus (gel bodies of the intervertebral disks) replacement, and to a process and to an apparatus for administration thereof, to the use thereof and to a vessel which comprises an inventive PVA gel. | 03-31-2011 |
| 20110082498 | METHODS FOR STERNAL CLOSURE - A method for sternal closure of a separated sternum includes applying an adhesive to a portion of an incision between at least a first sternum portion and at least a second sternum portion and maintaining the first sternum portion proximate to the second sternum portion until the adhesive has bonded with the first sternum portion and the second sternum portion. The adhesive may be applied over substantially the entire length of the incision or may be applied in intervals. The method for sternal closure may also include compressing the first sternum portion and the second sternum portion together using one or more compression devices and introducing adhesive to contact regions where the compressive devices contact the sternum. The method may also include cutting an interface feature in the first and second sternum portions or spanning the incision between the first and second interface portions with a structural support. | 04-07-2011 |
| 20110125187 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 05-26-2011 |
| 20110137339 | DUAL-ENDED APPLICATOR DISPENSING TWO FLUIDS - An applicator for dispensing two separate tissue adhesives includes a generally elongate body having two distinct interior regions, each containing one of the two tissue adhesives. Hinged levers associated with each region selectively force the expulsion of the adhesive from the end portions of the applicator in response to application of force by the operator. | 06-09-2011 |
| 20110152925 | Skin Preparation That Immobilizes Bacteria - Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. This two step process is time consuming, as each layer must dry before the next one is applied. A skin preparation is provided that immobilizes at least 95 percent of bacteria on the skin and is essentially free of cyanoacrylate. The skin preparation has a fugitive solvent and may also have antimicrobial compounds like iodophors, biguanides, phenols, quaternary amines, antibiotics and metals. This skin preparation may be used without an additional skin sealant or incise applied over it prior to surgery. | 06-23-2011 |
| 20110166596 | Mixing System, Kit and Mixer Adapter - A system includes a cylinder having a bore with a piston disposed therein, the piston moveable along the bore of the cylinder and having a passage therethrough. The system also includes a mixer disposed in the passage in the piston and including at least one porous mixing device, the at least one porous mixing device comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and having physical characteristics to sufficiently mix the first and second components, which characteristics include a selected one or more of mean flow pore size, thickness and porosity. | 07-07-2011 |
| 20110190813 | PHOTOACTIVATED CROSSLINKING OF A PROTEIN OR PEPTIDE - A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial. | 08-04-2011 |
| 20110190814 | SYSTEM AND METHOD FOR SURGERY - A method and system for conducting surgical procedures is disclosed. | 08-04-2011 |
| 20110224723 | CYANOACRYLATE TISSUE ADHESIVES - A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying a tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive. | 09-15-2011 |
| 20110224724 | HYDROGEL TISSUE ADHESIVE FORMED FROM AMINATED POLYSACCHARIDE AND ALDEHYDE-FUNCTIONALIZED MULTI-ARM POLYETHER - A hydrogel tissue adhesive formed by reacting an aminated polysaccharide with a water-dispersible, aldehyde-functionalized multi-arm polyether is described. The hydrogel tissue adhesive may be useful as a general tissue adhesive and sealant for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions. Additionally, due to the presence of the aminated polysaccharide, the hydrogel tissue adhesive may also promote wound healing and blood coagulation, and provide antimicrobial properties. | 09-15-2011 |
| 20110238109 | SURGICAL FASTENERS AND METHODS FOR SEALING WOUNDS - A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. | 09-29-2011 |
| 20110276088 | Synthetic Polymer Adhesives And Methods For Making, Using And Delivering The Same - A synthetic polymer based adhesive formulation that has properties substantially simulating selected properties of fibrin glue, and methods of making and using the same. The adhesive formulation includes a discrete acid solution and discrete base solution that when combined form a synthetic polymer based adhesive that substantially simulates selected properties of fibrin glue. The discrete acid solution includes a polymer and a cross-linking agent precursor. The discrete base solution includes a polymer and a base. | 11-10-2011 |
| 20120029559 | MULTIBRANCHED BIOADHESIVE COMPOUNDS AND SYNTHETIC METHODS THEREFOR - The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins. | 02-02-2012 |
| 20120041481 | COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE - Kits comprising dry power compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The dry powder composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked biomaterials include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury. | 02-16-2012 |
| 20120046691 | BIOPSY INCISION CLOSURE DEVICE - A biopsy incision closure device comprises a base having a frame incorporated therein. Together, the base and frame define an opening for performing a biopsy incision when the device is placed over a tissue surface. The base is typically composed of an elastomeric material and the frame comprises resilient inelastic members which can be used to close the opening in a highly uniform manner with minimum distortion and stress introduced into the tissue edges being drawn together. | 02-23-2012 |
| 20120065674 | METHODS AND MATERIALS FOR CLOSING AN OPENING - This document provides methods and materials for closing an opening (e.g., an incision) within a mammal. For example, methods and materials for closing a transluminal incision created during a natural orifice transluminal endoscopic surgery are provided. | 03-15-2012 |
| 20120065675 | Methods and Apparatus for Temporarily Occluding Body Openings - Methods and apparatus are provided for temporarily occluding a body opening. A method in accordance with one or more embodiments of the invention includes introducing a tip of a catheter into the body opening, the tip including a central longitudinal axis; expelling a thermosensitive polymer from the tip of the catheter into a portion of the body opening, allowing the thermosensitive polymer to harden as it warms to body temperature to form a plug in the body lumen, and removing the plug. | 03-15-2012 |
| 20120078296 | BIOMIMETIC COMPOUNDS AND SYNTHETIC METHODS THEREFOR - Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings. | 03-29-2012 |
| 20120089180 | ADHESIVE BONDING COMPOSITION AND METHOD OF USE - A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like. | 04-12-2012 |
| 20120136387 | PHOTOCHEMICAL TISSUE BONDING - Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair. | 05-31-2012 |
| 20120158048 | DEVICE FOR MIXING AND DISPENSING OF TWO-COMPONENT REACTIVE SURGICAL SEALANT - An applicator for mixing and applying multi-component compositions to a work surface, such as two-component surgical sealants. A luer hub sub-assembly having a proximal hub and a distal hub, an elongate, four-lumened cannula, and a spray tip sub-assembly are provided, with interconnections between the sub-assemblies preserving isolation of the fluid components from one another. The tip cap sub-assembly includes registration structure to assure proper alignment between tip cap and tip insert. The end wall of the tip cap includes a spinner region with three feeders or feeder channels leading thereto, the fluid components remaining isolated from one another in two of the feeders or feeder channels, and initiating mixing with one another in a third of the feeders or feeder channels. | 06-21-2012 |
| 20120191132 | Two Part Tape Adhesive for Wound Closure - A wound closure device includes a first applicator including a handle portion and a substrate engaging portion and a second applicator including a handle portion and a substrate engaging portion. A first substrate is releasably couplable to the substrate engaging portion of the first applicator and includes a tissue reactive surface and a self-reactive surface. A second substrate is releasably couplable to the substrate engaging portion of the second applicator and includes a tissue reactive surface and a self-reactive surface. The self-reactive surfaces of the first and second substrates each possess reactive groups known to have complementary functionality for bonding the first and second substrates together. | 07-26-2012 |
| 20120197293 | HYDROPHILIC BIODEGRADABLE ADHESIVES - A moisture-curable and biodegradable adhesive that includes the reaction product of: (a) an isocyanate component having an average functionality of at least 2; (b) an active hydrogen component having an average functionality greater than 2.1; and (c) an ionic salt component having an average hydroxyl or amino functionality, or combination thereof, of at least 1. | 08-02-2012 |
| 20120209323 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided. | 08-16-2012 |
| 20120209324 | BIODEGRADABLE, NON-TOXIC BIOLOGICAL ADHESIVE FOR USE IN ABDOMINAL SURGERY - A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing prosthesis during a hernia operation in a patient and occluding a fistula within a patient. | 08-16-2012 |
| 20120221044 | Dynamic Tensioning System and Method - Systems and methods of applying dynamic force to tissues to promote healing. Systems of this invention may be applied to tissue to bolster the tissues, move the tissues, or expand the tissue. Systems of this invention may also include a tension indication feature, allowing measured application of dynamic force to the tissue. | 08-30-2012 |
| 20120245627 | Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers - One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema. | 09-27-2012 |
| 20120296374 | TISSUE EVERSION APPARATUS AND TISSUE CLOSURE DEVICE AND METHODS FOR USE THEREOF - Methods and apparatuses for closure of vascular punctures or other openings in bodily tissues. The apparatuses and methods described herein are configured for everting a portion of tissue around a puncture site for wound closure on the external surface of the wound. For example, the tissue eversion apparatus may be configured for drawing up a portion of a vessel surrounding a venous or arterial puncture and orienting the inner surface of the vessel at least partially outward so that a closure element may be placed around the inverted region on the exterior surface of the vessel. In some embodiments, the devices are bioabsorbable. | 11-22-2012 |
| 20130006301 | Material For Treating Lumen Defects - A method of treating tissue defects includes placing at least one polymeric sheet over a tissue defect, in embodiments a lumen defect, to define a defect volume and filling the defect volume with at least one hydrogel precursor including at least one reactive functional group. | 01-03-2013 |
| 20130018414 | Devices, Systems and Methods for Closure of Cardiac Openings - The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage. | 01-17-2013 |
| 20130110161 | SPRAY DELIVERY SYSTEM | 05-02-2013 |
| 20130165970 | BONDING TISSUES AND CROSS-LINKING PROTEINS WTH NAPHTHALIMIDE COMPOUNDS - Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin. | 06-27-2013 |
| 20130190812 | BIORESORBABLE TIP WITH LOW FORCE RELEASE AND METHODS - A vascular closure system includes an expandable anchor, a sealing material, a sealing tip, and a sealing tip release member. The expandable anchor is temporarily positioned through a vessel puncture within a vessel. The sealing material is positioned outside of the vessel and configured to seal the vessel puncture. The sealing tip is positioned distal of the anchor and releasable within the sealing material upon removal of the anchor and sealing tip through the sealing material. The sealing tip release member is operable to release the sealing tip without application of a tactile force. | 07-25-2013 |
| 20130190813 | BALLOON LOCATION DEVICE MANIFOLD FOR VASCULAR CLOSURE DEVICE AND METHODS - A vessel puncture closure device includes a housing, an inflation tube, a balloon member, an indicator member, and a delivery tube. The inflation tube defines an inflation lumen and extends from the housing. The balloon member is positioned at a distal end of the inflation tube and is arranged in fluid communication with the inflation lumen. The indicator member is positioned in and movable relative to the housing in response to a pressure condition in the balloon member. The delivery tube is connected to the indicator member and balloon member, and extends through the housing and inflation tube. | 07-25-2013 |
| 20130190814 | Internal Clamp for Surgical Procedures - One aspect of the present invention relates to a method of occluding a vascular site in a mammal, comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding a vascular site of said mammal, wherein said temporarily occluded vasculature site is kept in a substantially cylindrical shape. | 07-25-2013 |
| 20130211449 | CLOTTING CASCADE INITIATING APPARATUS AND METHODS OF USE AND METHODS OF CLOSING WOUNDS - Wound closure methods and apparatuses are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing coagulated blood to the wound site. Methods and apparatuses for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. | 08-15-2013 |
| 20130226229 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided. | 08-29-2013 |
| 20130238019 | METHOD FOR PREVENTING BLOOD LEAKAGE FROM A VESSEL - A method is provided for preventing leakage of blood from a vessel. The method includes inserting a portion of an apparatus into a puncture tract extending through tissue to a puncture in the vessel; the apparatus including a thrombogenic matrix disposed in a distal portion of the apparatus. The method also includes deploying the thrombogenic matrix from the distal portion of the apparatus and into the puncture tract, the thrombogenic matrix being exposed to blood and compressively engaging the tissue surrounding the vessel to prevent leakage of blood. | 09-12-2013 |
| 20130245680 | Closure Tape Dispenser - A surgical tape applicator includes a dispenser housing, a protective liner, and a surgical tape. The dispenser housing has a proximal end and a distal end and defines a passageway therethrough. The protective liner is disposed within the passageway of the housing. The surgical tape is at least partially disposed within the dispenser housing and protected by the protective liner. The surgical tape has a first surface and a second surface each having at least one tissue reactive component. | 09-19-2013 |
| 20130253579 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture through a vessel wall including a positioning assembly, a sheath releasably engaged with the positioning assembly, and a support member axially advanceable through the sheath. The positioning assembly includes a positioning element positioned at a distal portion of the positioning assembly and a sealant disposed at a distal portion of the positioning assembly. The sheath guides the sealant and positioning assembly to the puncture in the vessel wall. | 09-26-2013 |
| 20130253580 | ADHESIVE APPLICATOR FOR BIOLOGICAL TISSUE - An adhesive applicator for biological tissue ( | 09-26-2013 |
| 20130267996 | METHODS FOR SEALING A VASCULAR PUNCTURE - Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 10-10-2013 |
| 20130282055 | EXTRALUMINAL SEALANT APPLICATOR AND METHOD - An apparatus for applying sealant to a target tissue of a surgical site is provided. The apparatus includes a handle, conduit and an end effector. The handle has means configured and adapted for operating the end effector and dispensing biological sealant to the surgical site via the end effector. The conduit stores and/or carries sealant towards the end effector. The end effector is configured to clamp around a body organ or tissue and apply and confine biological sealant in a substantially uniform manner thereto. | 10-24-2013 |
| 20130325061 | Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers - One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema. | 12-05-2013 |
| 20130325062 | TISSUE ADHESIVE BASED ON NITROGEN-MODIFIED ASPARTATES - The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention. | 12-05-2013 |
| 20140018849 | MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES - A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue. | 01-16-2014 |
| 20140058442 | SEALANT STORAGE, PREPARATION, AND DELIVERY SYSTEMS AND RELATED METHODS - A bioadhesive sealant storage and preparation system may comprise a plurality of containers and an adapter. The plurality of containers may comprise a first container having a first bioadhesive sealant component therein, and a second container having a second bioadhesive sealant component therein. The adapter may comprise a manifold comprising a plurality of channels formed therein, an inlet region sized and configured to receive the plurality of containers and facilitate fluid communication between each container of the plurality of containers and a respective channel of the plurality of channels, and an outlet region sized and configured to receive a syringe and provide fluid communication between the syringe and the plurality of channels. | 02-27-2014 |
| 20140066981 | TISSUE ADHESIVE WITH ACCELERATED CURING - The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R | 03-06-2014 |
| 20140088642 | DEVICE AND METHOD FOR THE APPLICATION OF A CURABLE FLUID COMPOSITION TO A BODILY ORGAN - The invention relates to a device suitable for application of a curable fluid composition to encircle a bodily organ. The device comprises a monolithic piece of a flexible material having a length dimension with an inner surface and an outer surface, a first end and a second end, a width dimension, and two spaced-apart sides, wherein a portion of the length dimension proximal to the first end is configured to contact a portion of the length dimension proximal to the second end, the inner surface defining a hollow area between the two spaced-apart sides; and at least one inlet providing fluid communication between the outer surface and the inner surface, for introduction of the fluid into the hollow area. The device deployable around the bodily organ such that when the portion of the length dimension proximal to the first end contacts the portion of the length dimension proximal to the second end, an outer surface of the bodily organ and the hollowed area define an enclosed volume encircling the bodily organ, the enclosed volume suitable for containing the fluid therein. | 03-27-2014 |
| 20140094847 | FLUID APPLICATOR - Fluid applicators utilizing a cutter and an ampule containing fluids, such as topical adhesives, and methods for safe, sterile, one-time use of fluid applicators for expressing fluids, such as wound sealing adhesives, are provided. | 04-03-2014 |
| 20140121699 | DEVICE AND METHOD FOR DISPENSING A LIQUID AND A GAS - A device and method for dispensing a liquid and a gas from a tip includes a support structure, a control unit, and a drive unit. The liquid is held within a container. The support structure is adapted to hold the container. The control unit directs the drive unit to expel liquid from the container according to a predetermined rate. The control unit further directs the drive unit according to first, second, and third modes of operation. During the first mode, neither gas nor liquid is dispensed from the device. During the second mode, only gas is dispensed from the device. During the third mode, both gas and liquid are dispensed from the device. Furthermore, the control unit is only selectable and operable by a user through the first, second, and third modes in a sequential manner. | 05-01-2014 |
| 20140135830 | DUAL DELIVERY SYSTEMS, DEVICES, AND RELATED METHODS FOR BIOADHESIVES - A manifold for the delivery of bioadhesive sealant may comprise an inlet, a first outlet, a second outlet, and at least one valve positioned and configured to facilitate selective fluid communication between the inlet and the first outlet and the inlet and the second outlet. A syringe for delivering a bioadhesive sealant may comprise at least one barrel, at least one plunger, and at least one feature positioned and configured to prevent movement of the at least one plunger relative to the at least one barrel after a first predetermined quantity of bioadhesive sealant has been delivered. A bioadhesive sealant delivery system may comprise a manifold, a syringe, and a catheter, wherein a first lumen of the catheter is coupled to a first outlet of the manifold and a second lumen of the catheter coupled to a second outlet of the manifold. | 05-15-2014 |
| 20140135831 | BIOADHESIVE MIXING AND PREPARATION SYSTEMS AND METHODS USING TWO SYRINGES - A bioadhesive mixing assembly includes first and second syringes and an adapter. The first syringe includes first and second chambers holding a first sealant component and an activator, respectively. The second syringe includes third and fourth chambers holding a second sealant component and one of an activator or a third sealant component, respectively. The adapter is mounted to the first syringe and includes first and second channels in flow communication with the first and second chambers, a first seal member providing sealed access to the first and second channels, first and second needles connected in flow communication with the third and fourth chambers, and a second seal member enclosing the first and second needles. Connecting the adapter to the second syringe punctures the first and second seal members with the first and second syringes to create flow communication between the first and third chambers and the second and fourth chambers. | 05-15-2014 |
| 20140142624 | SHEATH APPARATUS AND METHODS FOR DELIVERING A CLOSURE DEVICE - An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening. | 05-22-2014 |
| 20140163610 | STERILIZED LIQUID COMPOSITIONS OF CYANOACRYLATE MONOMER MIXTURES - Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place. | 06-12-2014 |
| 20140207186 | Sealant Delivery Device for Anastomotic Stapler - The present invention relates to surgical instruments and a method for applying an adhesive or sealant to an anastomosis site immediately prior and/or during anastomotic surgical stapling. The present invention further relates to surgical instruments, devices, and methods for applying sealant to a target tissue of a surgical site being anastomotically joined so as to prevent leakage. | 07-24-2014 |
| 20140236226 | TAILORED POLYMERS - The present invention relates to shape memory polymers (SMP) and especially to shape memory polymer containing a water soluble non-reactive plasticiser and to uses thereof. | 08-21-2014 |
| 20140249575 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture. | 09-04-2014 |
| 20140324098 | TISSUE STABILIZATION AND REPAIR DEVICE - A device includes an elongated cannula with an opening positioned at its distal end. A tissue engagement structure is affixed proximate the distal end of the cannula and surrounds the opening. The tissue engagement structure includes a tissue engaging portion to engage and control tissue. An adhesive is dispensed through the cannula opening to repair tissue. | 10-30-2014 |
| 20140358179 | HEMOSTATIC SYSTEM AND ITS METHODS OF USE - A hemostatic system includes a first tube defining a first lumen configured to channel a fluid therethrough, a second tube housing at least a portion of the first tube and at least partially defining a second lumen configured to channel a hemocoagulant agent therethrough, a hopper coupled to the second tube, and an injection device. The hopper defines a cavity in fluid communication with the second lumen and is configured to retain the hemocoagulant agent therein. The injection device is selectively positionable within the second lumen and/or the cavity to facilitate channeling the hemocoagulant agent from the cavity through the second lumen. | 12-04-2014 |
| 20150289862 | Method and apparatus for occluding a physiological opening - A method and apparatus for suture-less placement of an occluding patch in which release of the device can be accelerated. In one embodiment, an inactive form of an adhesive is applied on the area of the patch that will come into contact with cardiac tissue; this allows for the introduction and necessary manipulation of the catheter system until activation of the adhesive occurs. In accordance with one aspect of the invention, the adhesive properties of certain polymeric materials are relied upon rather than their ability to cure or harden into a specific shape. In another embodiment, the patch is immediately released utilizing a detaching mechanism on the balloon or the balloon catheter which supports the patch; the patch along with the inflated balloon remain on the cardiac structure occluding the opening. | 10-15-2015 |
| 20150297202 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 10-22-2015 |
| 20150297206 | SURGICAL INSTRUMENT FOR DISPENSING A FLUID - A surgical instrument for dispensing a fluid includes a housing and a dispensing shaft, which is elongate and which has a proximal end and a distal end. The proximal end of the dispensing shaft is received in the housing and the distal end defines a dispensing opening for dispensing the fluid. The dispensing shaft includes a through bore which extends along the dispensing shaft from the proximal end to the dispensing opening at the distal end. The instrument further includes a dispensing assembly and a priming assembly connected to the housing which is operable to move an amount of the fluid into the through bore of the dispensing shaft to prime the through bore with the fluid before the dispensing assembly is operated. | 10-22-2015 |
| 20150297207 | SURGICAL INSTRUMENT FOR DISPENSING A FLUID - A surgical instrument for dispensing a fluid includes a housing and a dispensing shaft. The surgical instrument further includes a dispensing assembly connected to the housing, which includes a dispensing chamber for holding the fluid before it is dispensed. A container is included in which the fluid is stored before the surgical instrument is used. A transfer assembly is included and is connected to the housing which is operable to open the container and transfer the fluid from the opened container to the dispensing chamber before the dispensing assembly is operated. | 10-22-2015 |
| 20150313582 | HEMOSTATIC DEVICE AND ITS METHODS OF USE - A hemostatic device for sealing a puncture of a vessel includes a first tube defining a first lumen. The first lumen is configured to receive a guidewire and a flow of a fluid therethrough. The hemostatic device also includes a second tube circumscribing at least a portion of the first tube and at least partially defining a second lumen. The hemostatic device further includes a substantially rigid stopper coupled to a distal end of the second tube. The stopper defines a stopper lumen that receives the first tube therethrough in an interference fit. A first opening is defined in a side wall of the first tube and positioned distally relative to the stopper. At least one injection groove defined in an outer surface of the stopper cooperates with the distal end of the second tube to define at least one second opening in flow communication with the second lumen. | 11-05-2015 |
| 20150320422 | VASCULAR WOUND CLOSURE DEVICE AND METHOD - A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. Thus, the vascular puncture wound is sealed by natural blood clot formation. | 11-12-2015 |
| 20150320904 | TISSUE SEALANT IN WHICH COLLAGEN AND FIBRIN ARE MIXED, AND METHOD FOR PREPARING SAME - The present invention relates to a tissue sealant in which collagen and fibrin are mixed and to a method for preparing same. To this end, the method of the present invention comprises the steps of: mixing a first material using fibrinogen and aprotinin; mixing a second material using thrombin, calcium chloride, and collagen; and preparing a third material by mixing the first material and the second material. The tissue sealant prepared by the method may supplement weaknesses, i.e. strength and degradability, of the fibrin sealant which is currently available in the commercial marketplace. Further, the tissue sealant of the present invention is cytophilic and activates blood platelets contained in blood so as to induce tissue regeneration. Thus, quality and reliability of products can be significantly improved so as to satisfy various needs of consumers who are users, thereby presenting good image. | 11-12-2015 |
| 20150327846 | SPRAY APPLICATOR - A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip. | 11-19-2015 |
| 20150342581 | CHITOSAN AND POLYETHYLENE GLYCOL COPOLYMERS AND METHODS AND DEVICES FOR USING SAME FOR SEALING A VASCULAR PUNCTURE - A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided. | 12-03-2015 |
| 20150351760 | DEVICES AND METHODS FOR SEALING STAPLES IN TISSUE - Devices and methods for applying sealants to surgical instruments are described herein. In one embodiment, a surgical device is described that can include at least one nozzle formed at a proximal end of the device that is configured to receive a sealant, as well as an applicator formed at a distal end of the device that is configured to deliver the sealant received by the at least one nozzle. The applicator can be configured to interface with at least one of a first and second jaw of a surgical stapler such that the sealant delivered from the applicator can be deposited into a plurality of openings formed in the surgical stapler. | 12-10-2015 |
| 20160000418 | HEMOSTATIC AGENT APPLICATOR - Disclosed is a hemostatic agent applicator capable of effectively placing a fluid hemostatic agent on an incision surface. The present invention is a hemostatic agent applicator for use in disposing a fluid hemostatic agent, including a tool body in which a hollow part surrounded by a wall part is formed and which includes an open end part on a downstream side of the wall part, and an inlet provided to a portion of the wall part of the tool body to communicate with the hollow part. This hemostatic agent applicator is useful in medical settings relating to surgical procedures, particularly for surface bleeding of a liver and internal organ surgery such as a spleen and fibroid enucleation. An applicator further reduced in size can be applied not only in abdominal surgery, but in endoscopic surgery as well. | 01-07-2016 |
| 20160030027 | DISPOSABLE SYRINGE APPLICATORS FOR MULTI-COMPONENT FORMULATIONS, AND METHODS OF USE THEREOF - Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. | 02-04-2016 |
| 20160038347 | COMPOSITIONS HAVING CYLINDRICAL VOLUME, METHODS, AND APPLICATORS FOR SEALING INJURIES - Disclosed are solid and frozen haemostatic materials having a rod shape and suitable applicators and plungers for application of such dressings to wounded tissue wherein said dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques. | 02-11-2016 |
| 20160113636 | VASCULAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids. | 04-28-2016 |
| 20160114075 | PHOTOACTIVATED CROSSLINKING OF A PROTEIN OR PEPTIDE - A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial. | 04-28-2016 |
| 20160135796 | APPARATUS AND METHOD FOR SEALING A VASCULAR PUNCTURE - A closure system for delivering a sealant to an arteriotomy. A distal section of the closure system can include overlapping inner and outer sleeves that can expand with expansion of the sealant. A proximal section of the closure system can include a handle portion and a sheath adapter extending from the handle portion. The handle portion can comprise one or more actuators that when depressed or engaged can assist in deployment of the sealant in the arteriotomy and can further include tamping of the sealant and/or retraction of an expandable member. The sheath adapter can removably engage a side port or an irrigation line of a standard procedural sheath. When the sheath adapter is secured to the procedural sheath, movement of the closure system can also move the procedural sheath. | 05-19-2016 |
| 20160249897 | Vascular Closure Devices and Methods Providing Hemostatic Enhancement | 09-01-2016 |
| 20160250377 | LIGHT ACTIVATED COMPOSITE TISSUE ADHESIVES | 09-01-2016 |
| 20170232157 | TISSUE INTEGRATING MATERIALS FOR WOUND REPAIR | 08-17-2017 |
