| Entries |
| Document | Title | Date |
|---|
| 20080200884 | Thin wall surgical irrigation tubing with longitudinal reinforcements - A length of ophthalmic surgical irrigation tubing | 08-21-2008 |
| 20080243095 | Method and Apparatus for Ophthalmic Medication Delivery and Ocular Wound Recovery - An annular device may include a biocompatible material. The device may be configured to substantially conform to a curvature of an eye. The device may be placed on a surface of the eye such that the device surrounds, but does not cover, the cornea. The device may cover a site of one or more incisions in a sclera of the eye without extending past an edge of a bulbar conjunctiva of the eye. | 10-02-2008 |
| 20090093780 | INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS - The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing. | 04-09-2009 |
| 20090093781 | MEMS Flow Module with Filtration and Pressure Regulation Capabilities - Various embodiments of MEMS flow modules that both filter and regulate pressure are disclosed. One such MEMS flow module ( | 04-09-2009 |
| 20090171305 | COMBINATION THERAPY FOR LONG-LASTING CKR - Corneal collagen crosslinking of CKR™-treated cornea results in a long-lasting, potentially permanent correction of corneal shape and improved vision. | 07-02-2009 |
| 20090240217 | NOVEL MICROFABRICATED INSTRUMENTS AND METHODS TO TREAT RECURRENT CORNEAL EROSION - In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye. | 09-24-2009 |
| 20090306608 | OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS - The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient. | 12-10-2009 |
| 20090312724 | Nasal and Ophthalmic Delivery of Aqueous Corticosteroid Solutions - The present invention is directed to methods of treating nasal and/or ophthalmic diseases, symptoms, or disorders that are therapeutically responsive to corticosteroid therapy by delivering aqueous solution formulations comprising a corticosteroid to nasal and ophthalmic tissues. The invention is also directed to methods, systems, devices, and compositions for delivering aqueous solution formulations comprising a corticosteroid and an antihistamine to nasal and ophthalmic tissues. | 12-17-2009 |
| 20100004609 | EYE COLORING SYSTEMS - A novel system for coloring the sclera of a human eye, including steps of accessing the conjunctiva, drying a portion of the conjunctiva, applying one or more colorants to the dried portion of the conjunctiva, drying the colorant, and closing access to the conjunctiva. The system avoids tattooing, implanting, and corneal modification. Permanent results may be obtained. Colorants may be coverings or stains. | 01-07-2010 |
| 20100004610 | EYE COLORING SYSTEMS - A method for suspending colorant in a subconjunctival space of a human eye, including steps of accessing the subconjunctival space, injecting colorant into the subconjunctival space, suspending colorant in the subconjunctival space, spreading the colorant into a desired pattern, and closing access to the subconjunctival space. The system avoids tattooing, implanting, and corneal modification. Permanent results may be obtained. Colorants may be suspensions or stains. | 01-07-2010 |
| 20100057024 | Easy-application meatal plug - A meatal plug, comprising a stem and a bulb arranged at one end of the stem, the bulb protruding laterally over said stem, a hole being formed in the plug, and the hole opening at the end of the stem opposite the bulb and said hole extending at least into the bulb, characterised in that the ratio of the height dimension of the stem, measured along its longitudinal axis to the length dimension along this same bulb axis is greater than 1, preferably greater than 2.5, the ratio of the width dimension of the bulb to its length, i.e. measured in a direction perpendicular to the stem axis, is greater than 1, preferably greater than 2.5. | 03-04-2010 |
| 20100106111 | DISPOSABLE SLEEP MASK FOR TREATING DRY EYE SYNDROME - A mask for the relief of dry eye in a dry eye subject, including a unitary shell shaped to cover at least one eye and a portion of a face. The shell includes a first layer and a second layer the first layer that is substantially moisture impermeable and the second layer that is moisture absorbent. The first layer and the second layer meeting at a layer interface. The first layer and the second layer are substantially coextensive over substantially the entire layer interface and are secured together over substantially the entire layer interface. | 04-29-2010 |
| 20100286632 | Multi-Layer Heat Assembly For A Drug Delivery Device - In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive. | 11-11-2010 |
| 20100331796 | OCULAR DRUG DELIVERY DEVICE - An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc. | 12-30-2010 |
| 20110022010 | METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID JET - According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction. | 01-27-2011 |
| 20110106024 | CONTAINER WITH A SQUEEZED NOZZLE AND LEVER - A container includes a nozzle having rubber elasticity in a constriction part, and a lever for nipping the nozzle indirectly. The nozzle has a storage part, a base, and a valve. The storage part is provided in the constriction part, and is intercepted with the main body by contacting inner walls at the communicating part when the nozzle is nipped and flattened by the lever. The valve is opened when the internal pressure of the storage part exceeds predetermined pressure while operated state and spouts liquid in the storage part. The constriction part expands by being nipped with the lever until the internal pressure of the storage part reaches to predetermined pressure. Liquid in the storage part is jetted since the constriction part shrinks by the rubber elasticity when the valve is released. | 05-05-2011 |
| 20110130729 | METHOD AND APPARATUS FOR TREATING GLAND DYSFUNCTION - A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material. | 06-02-2011 |
| 20110152797 | PROSTAGLANDINS AND ANALOGUES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE - The present invention relates to cyclopentane heptenoic acid-5-cis-2-(3α-hydroxy or lower alkyloxy-5-thienylpentyl)-3,5-dihydroxy, [1α, 2β, 3α, 5α] compounds, lower alkyl, hydroxyl lower alkyl and indole lower alkyl amides and esters thereof as potent ocular hypotensives that are particularly suited for the management of glaucoma. | 06-23-2011 |
| 20110166535 | VISION CORRECTIVE JIG AND COOLING FLUID INJECTION TOOL FOR THE JIG - A jig and a cooling fluid injection tool that are used in the correction of corneal shape conducted while the cornea of the eyeball is warmed and softened are provided. The vision corrective jig | 07-07-2011 |
| 20110196320 | METHOD FOR ASPIRATING FLUID UTILIZING A DUAL CYLINDER VACUUM PUMP - Irrigation fluid is aspirated from an eye and through an aspiration instrument by operating a vacuum pump, including moving first and second plungers between respective suction strokes and discharge strokes. Vacuum pressure at an input side of the pump is maintained at a desired vacuum pressure setting by controlling speeds and directions of the plungers, and controlling positions of input and output valves communicating with cylinders in which the plungers move. Controlling is based on the pressure setting and measured pressures in the cylinders. Vacuum pressure is maintained while transitioning from the suction stroke of the first plunger to the suction stroke of the second plunger, by synchronizing respective positions of the plungers and the valves, such that initiation of the suction stroke of the second plunger during the transitioning is delayed until a vacuum pressure in the second cylinder is equal to a vacuum pressure in the first cylinder. | 08-11-2011 |
| 20110202020 | TREATMENT MEDIUM DELIVERY DEVICE AND METHODS FOR DELIVERY OF SUCH TREATMENT MEDIUMS TO THE EYE USING SUCH A DELIVERY DEVICE - A device for delivering a treatment medium to an eye includes a first body portion configured to be removably inserted and secured in an opening of the eye, and a second body portion supported by the first body portion. At least the second body portion includes a treatment medium, and a coating having an opening through which the treatment medium elutes out of the device. | 08-18-2011 |
| 20110251568 | PUNCTAL PLUGS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled release into the eye by means of an osmotic engine. | 10-13-2011 |
| 20110301555 | POROUS MATRIX DRUG CORE FOR LACRIMAL INSERT DEVICE - Disclosed are novel structures and methods for drug cores containing therapeutic agents. Such cores may be inserted or manufactured in lacrimal insert devices for treating a variety of ocular conditions by eluding therapeutic agents according to a release profile determined by the structure and composition of the drug core. | 12-08-2011 |
| 20120059338 | PUNCTAL PLUG CONTAINING DRUG FORMULATION - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye and is configured for release medication via a designated port, valve, or orifice in the insert housing and inhibits diffusion of medication via the housing itself. | 03-08-2012 |
| 20120065600 | DEVICE FOR DISPENSING MICROLITER QUANTITIES OF A MATERIAL INTO A LONGITUDINALLY EXTENDING WOUND SITE - A seal-less, hand-held dispensing device for dispensing microliter quantities of a material at a site of a slice wound the edges of which are spaced apart a distance in the range from at least about 0.4 mm to about 0.5 mm comprises: a support platform; first and second hollow members on the platform; and a compatibly sized plunger disposed in each hollow member. Each hollow member has a predetermined maximum outside dimension that is not greater than about 0.4 mm such that both of the hollow members are insertable into a space between the edges of a slice wound without undue disruption of any tissue matter surrounding the site. The largest outside dimension of each compatibly sized plunger being in a range from about eighty percent (80%) to about ninety-five percent (95%) of the largest inside diameter of a hollow member in which it is disposed. | 03-15-2012 |
| 20120065601 | Lacrimal Punctum Measurement and Occlusion - Methods and apparatus for treatment of dry eyes by providing a single apparatus for measuring the diameter of the lacrimal punctum and, based on the measured punctal diameter, inserting therein an appropriately sized punctum plug. | 03-15-2012 |
| 20120109082 | DEVICES FOR DELIVERING AT LEAST ONE ACTIVE AGENT TO TISSUE - A device for delivering an active agent to target tissue at a site that includes a bodily fluid includes a body having a first exterior surface including a first section having a local, discrete recessed area formed in the body for holding the active agent. The body includes a surface flow feature in the form of a canal that is formed in the body and is recessed relative to the exterior surface. The surface flow feature interfaces with the first section and the local recessed area and is configured so as to guide or modify flow of the bodily fluid relative to the body such that fluid communication is provided between the bodily fluid and the local recessed area. The local recessed area is recessed relative to at least a portion of the canal. | 05-03-2012 |
| 20120157938 | PUNCTAL PLUG WITH DRUG CORE RETENTION FEATURES - Disclosed are lacrimal inserts and their method of use for delivery of of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye and is configured to release medication via a designated port, valve, or orifice in the insert housing and inhibits diffusion of medication via the housing itself The core may include retention features to ensure that it remains securely located within the lacrimal insert over its usable life. | 06-21-2012 |
| 20120197217 | PUNCTAL PLUGS WITH DIRECTIONAL RELEASE - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid and includes means for directional release of medication into the lacrimal fluid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye. | 08-02-2012 |
| 20120197218 | APPARATUS AND METHOD FOR RECONSTITUTING A PHARMACEUTICAL AND PEPARING THE RECONSTITUTED PHARMACEUTICAL FOR TRANSIENT APPLICATION - An apparatus and method for preparing a pharmaceutical for transient application includes a tray having a sealed compartment, a vial of an ophthalmic formulation of mitomycin-C, a diluent carrier containing sterilized water, and a syringe that are all contained together in a single package. The component parts of the apparatus are used together to reconstitute the contents of the vial with the water in the diluent carrier, and then draw the reconstituted drug into the sealed compartment of the tray by a suction force produced by the syringe. In the tray compartment, the reconstituted drug is absorbed in at least one absorbent pad. The absorbent pads may come in multiple shapes and or/sizes. The tray is opened to remove the pad and the absorbed drug from the tray compartment for use of the pad in transient application of the drug. | 08-02-2012 |
| 20120245539 | LACRIMAL IMPLANTS INCLUDING SPLIT AND INSERTABLE DRUG CORE - Lacrimal implants providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body, including first and second portions, extending from a proximal end of the first portion to a distal end of the second portion. The second portion includes a retention projection. The implant body can also include a cavity longitudinally extending from the proximal end of the first portion toward the second portion, wherein the cavity is shaped and sized to receive an insertable actuator, and wherein the retention projection is configured to bias outward or change orientation when the insertable actuator is seated within the cavity. | 09-27-2012 |
| 20120253299 | Multi-Piece Punctal Plug - A multi-piece punctal plug has one a superficial plug removably connected to an anchor plug deeper in the naso-lacrimal canaliculus. The anchor is fixed to the wall of the lacrimal duct while the superficial plug is axially and detachably secured to the anchor plug so that the multi-plug complex may be inserted or removed together as one, or the superficial plug may be detached separately and replaced securely without disturbing the anchor. Removal and insertion is accomplished by a specific tool having an end for reversibly engaging the plugs. | 10-04-2012 |
| 20120271252 | MEDICAL FLUID NOZZLE - Disclosed is a medical fluid nozzle which makes fluid drops less likely to remain at its tip portion after the medical fluid is dropped. The medical fluid nozzle | 10-25-2012 |
| 20120277694 | PUNCTAL PLUG WITH ACTIVE AGENT - A punctal plug for insertion through a punctal aperture of an eye. The punctal plug includes a stem configured to be inserted into the punctal aperture and along a canaliculus of the eye, a stopper connected to one end of the stem, the stopper configured to seat against the punctal aperture, and a topical prostaglandin. The stem and the stopper are made from a porous or absorbent material, and wherein the material is saturated with the topical prostaglandin. | 11-01-2012 |
| 20120283669 | PUNCTAL PLUGS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye. | 11-08-2012 |
| 20130023837 | Punctal plug inserter and method - A surgical tool for inserting a spile or plug into the punctal opening of a meatus such as a lacrimo-nasal canaliculus comprises an oblong, hollowed member shaped and dimensioned to be conveniently manipulated with one hand and having at one of its end a punctal opening and meatus-dilating shaft and, at the opposite end, a plug inserter. The dilating shaft has a cross-diameter substantially equal to the cross-diameter of the plug and is terminated by a conical spike. The inserter comprises a tip extending axially from the member and having, at its distal end, a cup whose internal geometry is commensurate with a cap at the proximal end of the plug. A penetration-resisting bearing surface is provided by the cup rim. The plug can be allowed to retract within the cup under the force of insertion. A steel wire running through the inserter has its distal end inserted into the cap of the plug. The wire can be axially withdrawn by unidirectionally pressing a button in order to release the plug after insertion into the meatus. | 01-24-2013 |
| 20130023838 | OCULAR DRUG DELIVERY DEVICE - An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc. | 01-24-2013 |
| 20130066283 | Corneal Denervation for Treatment of Ocular Pain - Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment. | 03-14-2013 |
| 20130090611 | PUNCTAL PLUGS - Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end. | 04-11-2013 |
| 20130123718 | PUNCTAL PLUGS - Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end. | 05-16-2013 |
| 20130131612 | PUNCTAL PLUGS - Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end. | 05-23-2013 |
| 20130172829 | DRY EYE TREATMENT SYSTEMS - Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin. | 07-04-2013 |
| 20130184662 | SYSTEMS AND METHODS FOR WOUND PROTECTION AND EXUDATE MANAGEMENT - The present invention provides systems and methods for protecting a wound and managing exudate released from the wound comprising a dressing having a support cushion for surrounding the wound and periwound region; a wicking strip for application in the periwound region between the support cushion and the wound; and a reservoir for application over the wicking strip, the wicking strip configured to transfer exudate from the wound to the reservoir, where the exudate is sequestered. Various alternative embodiments are described in which the wicking strip may be custom-fit to approximate an irregular wound margin, to apply a preferred pressure gradient to the periwound regions, to periodically apply fluids to the wound bed or to apply negative pressure wound therapy. Methods of applying the dressing also are provided. | 07-18-2013 |
| 20130226110 | PUNCTAL PLUG WITH ENERGIZED CONTAINMENT ARRAY - The disclosure relates to a semiconductor device comprising an array of containment cells, wherein each containment cell is configured to contain a medicament and each containment cell comprises a cell activation element configured to release the medicament within the containment cell upon receipt of an activation trigger. | 08-29-2013 |
| 20130226111 | DRUG SUPPORT BODY, AND METHOD FOR PRODUCING SAME - A drug support body is provided that can be used to appropriately administer a drug to the anterior segment of the eye while the production cost is reduced. A drug layer containing a drug component to be administered to an anterior segment of the eye is provided at a halfway portion in a longitudinal direction of a base plate, wherein the base plate includes a bending portion that allows the base plate to bend in a direction opposite to a surface of the base plate on which the drug layer is provided, and by bending the base plate at the bending portion, at least a portion of a surface facing the base plate of the drug layer is exposed from the base plate. | 08-29-2013 |
| 20130253451 | DRUG CARRIER DEVICE ATTACHABLE TO GLASSES - Disclosed is a drug carrier device attachable to glasses, which is attached to the glasses and worn with the glasses around the eyes to enable transdermal delivery of drugs for medicinal ingredients for promoting eye fatigue recovery and improving eye diseases. The drug carrier device includes a drug carrier containing medicinal herb ingredients, and a fixing unit for detachably fixing the drug carrier on a frame of glasses. The fixing unit extends from the drug carrier and has a fixing loop whose end portion is bent to be hooked on frame of the glasses. The frame of the glasses is made of a metal to be magnetically coupled to a magnet and the fixing unit includes a permanent magnet magnetically coupled to the frame of glasses. The drug carrier device is attached to the glasses to enable drugs to penetrate into the skin around the eyes of the wearer during everyday life, thereby minimizing the cost burden associated with providing an additional pad fixing member and reducing feeling of irritation. In addition, the drug carrier device of the present invention may be attached to glasses worn at normal times, thus achieving maximized convenience of use. | 09-26-2013 |
| 20130274691 | COMBINED DRUG DELIVERY METHODS AND APPARATUS - Methods and apparatus provide treatment with a first therapeutic agent and a second therapeutic agent for an extended time. The first therapeutic agent may comprise a VEGF inhibitor and the second therapeutic agent may comprise an antiinflammatory, such as a non-steroidal anti-inflammatory, for example a cyclooxygenase inhibitor. One or more of the first therapeutic agent or the second therapeutic agent can be injected into the eye, for example injected into a therapeutic device implanted into the eye to release the injected therapeutic agent for an extended time. | 10-17-2013 |
| 20130274692 | SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY - A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side. | 10-17-2013 |
| 20130324949 | DRUG DELIVERY DEVICES, KITS, AND METHODS THEREFOR - Implantable drug delivery devices, and kits and methods incorporating them are described. The devices may, for example, be configured for implantation into an ocular region of a subject. The drug delivery devices may comprise multiple, selectively-triggerable drug reservoirs for administration of sequential or concomitant drug regimens. Some variations of devices may comprise one or more reservoirs that may be triggered by an optical stimulus, e.g., light having a wavelength within a certain wavelength range. The devices, methods, and kits may be useful in the treatment chronic ocular conditions, such as age-related macular degeneration. | 12-05-2013 |
| 20130338611 | PULSATILE RELEASE OF MEDICAMENTS FROM A PUNCTAL PLUG - This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core. | 12-19-2013 |
| 20130338612 | APPARATUS FOR INTRAOCULAR INJECTION - An apparatus for intraocular injection comprising a body adapted to accommodate an injection device and a displacement device coupled to a distal portion of the body. The displacement device comprises a first portion and a second portion connected to the first portion. Axial movement of the first portion within the body in a distal direction causes the second portion to displace a superficial layer of an eye relative to an underlying layer of the eye. | 12-19-2013 |
| 20140025023 | WASTE COLLECTION SYSTEM FOR AN EYEWASH STATION - An eyewash station includes a body, a door, and a waste collection system for waste eyewash solution. The body contains an eyewash solution source having a defined solution volume. A first area of the door is pivotally connected to the body. An internal surface of a second area of the door has a dispensing member in fluid communication with the eyewash solution source. The second area of the door has a waste collection system including a flexible container, such as a rolled bag. In operation, the eyewash solution is dispensed from the dispensing member and then the waste eyewash solution collected and contained in the rolled bag. | 01-23-2014 |
| 20140031769 | THERAPEUTIC AGENT FORMULATIONS FOR IMPLANTED DEVICES - An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release. | 01-30-2014 |
| 20140135716 | Intraocular Medicament Delivery Device - Described is a medicament delivery device comprising a body adapted to be placed on the eye and a reservoir formed in the body containing a medicament. The body has a first surface adapted to contact at least a portion of the eye and be centered around a cornea. At least one projection is formed on the first surface. The projection includes a channel adapted to create a fluid flow path for the medicament from the reservoir to a terminal end of the projection. | 05-15-2014 |
| 20140155842 | APPARATUS AND METHODS FOR IMPLANTING PARTICULATE OCULAR IMPLANTS - Apparatus and methods for implanting ocular implants in eyes are provided which include a bent cannula having a lumen extending therethrough, the lumen having a length and a diameter and being configured to receive an ocular implant. The ocular implant is made up of a plurality of substantially uniformly sized particles, preferably a plurality of uniformly sized microspheres, arranged in a one-by-one array along the length of the lumen. The apparatus further comprises a mechanism for delivering the implant through the distal end of the lumen and into the eye, preferably without the use of a liquid or gel carrier medium located in the lumen along with the implant. | 06-05-2014 |
| 20140221941 | DIAGNOSTIC METHODS AND APPARATUS - An apparatus to treat a patient comprises a container to receive fluid of a device implanted in the eye. The fluid of the device can be analyzed to determine a component of the vitreous humor of the eye. | 08-07-2014 |
| 20140243763 | Devices for the Placement of Medical Compounds in Natural Orifices of a Body - Methods and devices for the delivering of medicinal compounds into the natural orifice of a being, human or otherwise, but most suitably for the delivery of a punctal plug to the punctum of a human. | 08-28-2014 |
| 20140257207 | APPARATUS FOR INTRAOCULAR INJECTION - Described is an apparatus for intraocular injection comprising a body adapted to accommodate a syringe having a needle, an outer sleeve telescopically coupled to the body, and at least two arms hingedly coupled to the outer sleeve. Each of the arms comprises a medial portion adapted to encase at least a portion of the needle. When the body moves distally relative 10 to said outer sleeve, the body engages the arms separating the medial portions. | 09-11-2014 |
| 20140276481 | SEALING AND ENCAPSULATION IN ENERGIZED OPHTHALMIC DEVICES WITH ANNULAR INSERTS - This invention discloses methods and apparatus for sealing and encapsulating Components on and within an annular-shaped Multi-Piece Insert. In some embodiments, an ophthalmic Lens is cast molded from a silicone hydrogel and the Component includes a sealed and encapsulated Multi-Piece Insert portion. | 09-18-2014 |
| 20140276482 | Systems for Sustained Intraocular Delivery of Low Solubility Compounds from a Port Delivery System Implant - Therapeutic agent delivery formulations for the sustained release of therapeutic agents from a Port Delivery System (PDS) implant is described in this application. | 09-18-2014 |
| 20140296802 | AID DEVICE FOR INTRAOCULAR INJECTION - Described is an aid device for an intraocular injection comprising a skirt having an aperture to receive an eye, and a cover coupled to the skirt. The cover has one or more guide holes adapted to receive a needle. | 10-02-2014 |
| 20140309599 | DEVICE FOR DISPENSING INTRAOCULAR SUBSTANCES - This disclosure relates generally to an injection device having a plunger configured to advance a distance into a container of material, such as a viscoelastic container; a trigger mechanism configured upon an actuation of the trigger mechanism to apply a first force to a spring element; and the spring element coupled to the plunger and configured to apply a second force to the plunger and which is configured to prevent exceeding a threshold maximum force applied to the container. | 10-16-2014 |
| 20150126945 | VITRECTOMY APPARATUS - A vitrectomy apparatus comprises a containment body ( | 05-07-2015 |
| 20150133878 | Ocular Insert Apparatus and Methods - A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time. | 05-14-2015 |
| 20160120693 | Eye Care Devices and Methods - Wipes and their use in methods of treatment of eye disorders such as dry eye or meibomian gland dysfunction. | 05-05-2016 |
| 20160128867 | Expandable Drug Delivery Devices and Methods of Use - Described are implantable devices having expandable reservoirs for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and includes a retention structure and a penetrable element coupled to and extending within at least a portion of the retention structure. A porous drug release mechanism is positioned in fluid communication with an outlet of the device; and a reservoir having a volume configured to contain one or more therapeutic agents is in fluid communication with the outlet through the porous drug release mechanism. The device is at least partially inserted along an axis of insertion. The reservoir enlarges from an insertion configuration having a first three-dimensional shape to an expanded configuration having a second three-dimensional shape, the second three-dimensional shape being eccentrically positioned relative to the axis of insertion. | 05-12-2016 |
| 20160184134 | Reservoir Device for Intraocular Drug Delivery - A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient. | 06-30-2016 |
| 20160375178 | INJECTABLE POROUS DEVICE FOR TREATMENT OF DRY AND WET AGE-RELATED MACULAR DEGENERATION OR DIABETIC RETINOPATHY - This disclosure provides a method for reducing or preventing the formation and/or accumulation of drusen in an eye of a mammalian subject in need thereof, the method comprising implanting one or more microporous devices into the eye, each device having a device body and an outer surface, wherein the microporous device is formed of a biocompatible elastomeric material and comprises a plurality of interconnected pores throughout the device body. | 12-29-2016 |
