Entries |
Document | Title | Date |
20080208134 | Micro-needle and micro-needle patch - Insertion of a micro-needle into a living body is made easy. The micro-needle includes first and second end sections arranged in a longitudinal direction and includes a biocompatible material, wherein the first end section tapers down from it's end on a side of the second end section toward another end thereof and the maximum apical angle of the first end section falls within a range of 9 to 53°. | 08-28-2008 |
20080221524 | NEEDLELESS MICROPROTRUSION ELASTOPLAST SYSTEM - A needleless microprotrusion system for infusion of a medicament into a patient includes a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient. A chemodenervating agent is disposed for delivery by the microprotrusions and a substrate is provided for supporting the microprotrusions and conforming the microprotrusions to a patient's fossa axilaaris in order to enable uniform penetration of the microprotrusions into the corneum. | 09-11-2008 |
20080269685 | Solvent-cast microneedle arrays containing active - In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient. | 10-30-2008 |
20080275400 | Manufacturing Microneedle Arrays - A method of making injection molded microstructured articles for drug delivery and tissue fluid sampling by injection molding the articles onto a carrier web to then convey the articles during the manufacturing process. The molded articles are attached to the web by closing the mold over a portion of the web prior to injection. This is particularly beneficial where the article has a highly sensitive surface, such as an array of delicate microneedles for drug delivery or fluid sampling. It also facilitates subsequent processing, which may include applying drug coatings and other processing. | 11-06-2008 |
20080294115 | Microscopic Tumor Injection Treatment - A tumor treatment system for treating a tumor within a body may include an injection system having an injector configured to inject an injection within the body that treats the tumor, and a robotic system configured to position the injector at a plurality of specified, spaced-apart treatment locations within the body. A tumor treatment process for treating a tumor within a body may include generating an image of the tumor within the body, identifying a plurality of locations within the body at which an injection that treats the tumor should be made based on the image, and making the injections at the locations under the control of a robotic system that is programmed to make the injections at the identified locations without human intervention. | 11-27-2008 |
20080294116 | Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings - Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt. | 11-27-2008 |
20090054842 | Enhanced penetration system and method for sliding microneedles - A microneedle device for transporting fluid through a surface of a biological barrier, the device including a fluid transport configuration, an abutment member and a displacement device. The fluid transport configuration includes a substrate having a substantially planar surface having a plurality of microneedles projecting therefrom. The abutment member has an abutment surface for abutting the biological barrier. The displacement device is configured for generating a relative lateral sliding movement between the surface of the biological barrier and the fluid transport configuration in a sliding direction of the microneedles The microneedles are arranged so that a leading microneedle defines an effective area which is effective void of another microneedle. The effective area is defined as an area marked out by translating the base area of the leading microneedle, by the height of the leading microneedle, in a direction opposite to the sliding direction. | 02-26-2009 |
20090198189 | DEVICE FOR APPLYING A MICRONEEDLE ARRAY | 08-06-2009 |
20090209916 | SEALANT APPLICATOR WITH MALLEABLE SECTION - An applicator device for applying at least one agent to a target site, including: a rigid section configured for the passage of fluid therethrough, the rigid section having a proximal end portion and a distal end portion, the proximal end portion configured for communication with at least one fluid reservoir; a formable section attached to the distal end portion of the rigid section, the formable section configured to be shaped into a desired configuration, the formable section including at least a first lumen and a second lumen, the first lumen configured to receive fluid from the rigid section; and a malleable member positioned within the second lumen, wherein the malleable member is configured to assist in retaining the formable section in the desired configuration. | 08-20-2009 |
20090240205 | RAILWAY LUMBAR COMBINED PUNCTURING NEEDLE - The present invention provides a puncture needle set for combined spinal-epidural anesthesia comprising an epidural needle with a small guiding conduit on the pin and a groove on the outer wall and a spinal needle with a beaked tip. During anesthesia, first the epidural needle is punctured into the epidural space, then the epidural catheter is placed, afterwards the spinal needle is guided to enter into the groove on the needle peduncle by the small conduit on the pin of the epidural needle and slide into the epidural space, then let it go ahead deep into subarachnoid space. After medicine is injected, the spinal needle and the epidural needle are withdrawn in turn, at the same time the epidural catheter is left back. | 09-24-2009 |
20090247953 | MICRONEEDLE ADAPTOR FOR DOSED DRUG DELIVERY DEVICES - An adapter for achieving intradermal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration for attachment to the dosed drug delivery device and a hollow needle deployed for piercing the septum. A liquid delivery interface, linked to the connector, includes a straight skin contact edge and one or more hollow microneedle adjacent thereto. The microneedle projects away from the skin contact edge. A flow path arrangement interconnects the needle and the at least one hollow microneedle. | 10-01-2009 |
20090275899 | Apparatus for treating subcutaneous tissues - An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors. | 11-05-2009 |
20090292254 | Micro-needle and micro-needle patch - Insertion of a micro-needle into a living body is made easy. The micro-needle includes first and second end sections arranged in a longitudinal direction and includes a biocompatible material, wherein the first end section tapers down from it's end on a side of the second end section toward another end thereof and the maximum apical angle of the first end section falls within a range of 9 to 53°. | 11-26-2009 |
20090292255 | MICRO-NEEDLE AND MICRO-NEEDLE PATCH - A micro-needle patch has microneedles extending from a first main surface, which is made of a material including chitin and/or chitosan. The micro-needle patch has a feed substance on at least one of the first main surface and a second main surface. The micro-needle patch makes insertion of the microneedles into a living body easier. The micro-needle patch is manufactured by pressing a plate having a recessed pattern on a surface thereof, the recessed pattern including recesses corresponding to micro-needles of at least one micro-needle patch, against a sheet or film of a raw material to form protrusions corresponding to the recesses on a surface of the sheet or film. | 11-26-2009 |
20100042050 | Microneedle Transdermal Delivery Device - A drug delivery device that delivers pharmacologically active substances transdermally using microneedles arranged on a belt mounted rotatably about a plurality of rollers, the microneedles having an associated drug reservoir mounted on the belt which is compressed when the needles and belt are brought into contact with the skin. | 02-18-2010 |
20100100048 | Medical Skin Mountable Device - A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner. | 04-22-2010 |
20100106093 | HOLLOW CURVED SUPERELASTIC MEDICAL NEEDLE AND METHOD - A needle assembly | 04-29-2010 |
20100130940 | METHOD OF MAKING MICRONEEDLE ARRAY AND DEVICE FOR APPLYING MICRONEEDLE ARRAY TO SKIN - Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle. | 05-27-2010 |
20100228199 | Surgical cassette for intraocular pressure control - An improved surgical cassette for controlling intraocular pressure during ophthalmic surgery. | 09-09-2010 |
20100262081 | MICRONEEDLE ROLLER AND STAMP ADAPTED TO ENABLE THE REPLACEMENT OF MICRONEEDLES - A microneedle-replaceable roller and stamp comprises a main body having a handle portion and a microneedle plate or sheet that is detachably mounted to the main body. According to the roller and stamp, inexpensive and sanitary application can be ensured. | 10-14-2010 |
20100280457 | Method Of Coating Microneedle - The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device ( | 11-04-2010 |
20100280458 | OUT-OF-PLANE MICRONEEDLE MANUFACTURING PROCESS - Out-of-plane microneedle manufacturing process comprising the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat ( | 11-04-2010 |
20100286618 | MULTI NEEDLE - An injector and a needle, which is engaged to the injector by using a needle hub, are disclosed. The multi needle comprises a needle hub which consists of one inlet into which a nozzle of an injector is inserted, and a plurality of outlets communicating with the inlet; and a plurality of needles which are inserted into the outlets of the needle hub, respectively. | 11-11-2010 |
20110021996 | STRUCTURE OF MICRO-NEEDLE WITH SIDE CHANNEL AND MANUFACTURING METHOD THEREOF - The present invention relates to a microneedle for delivering active agent or agents. The microneedle comprises a body a body having a base at one end thereof and a tip portion at the other end thereof; a pair of projections connected to a side of the body and having a base at one end thereof and a tip portion at the other end thereof; and a vertical groove defined by the body and the pair of projections. The distance between outer edges of the pair of projections is formed to become smaller towards the tip portion than the distance between outer edges of the body, and the upper end of each of the pair of projections is shorter than that of the body such that a free space is formed between the outer edges of the body and the pair of projections. | 01-27-2011 |
20110040256 | Insertion Device for an Insertion Set and Method of Using the Same - An insertion device and insertion set. The insertion device for inserting at least a portion of at least one piercing member of an insertion set through the skin of a patient includes a device housing, a carrier body and a driver. The carrier body is slidably received within the device housing for movement between an advanced position and a retracted position. The carrier body also includes a receiving structure to support the insertion set in a position with the at least one piercing member oriented for insertion through the skin of the patient at a predetermined or variable angle relative to the skin of the patient upon movement of the carrier body from the retracted position to the advanced position. The driver is operatively coupled between the device housing and the carrier body to urge the carrier body from the retracted position toward the advanced position to place at least a portion of the at least one piercing member of the insertion set thorough the skin of the patient to install the insertion set to the patient. The receiving structure of the carrier body is removable from the insertion set while maintaining the installation of the insertion set to the patient. | 02-17-2011 |
20110046556 | Rapid Local Anesthesia Injection Cone - This is a Local Anesthesia Injection Cone. It is made of a very simple cone shaped piece of clear plastic with a flange on the tip of the cone where a Luer lock syringe can attach. There are a multiple tiny hypodermic needles protruding from the base of the cone. The number of needles would be directly proportional to the diameter of the device. It would be available in many sizes identified by the diameter of the base of the cone. | 02-24-2011 |
20110046557 | MICRONEEDLE DRUG DELIVERY SYSTEM INCLUDING MOVABLE DRUG-CONTAINING CAPSULE - A microneedle drug delivery system comprises: a housing having an opening formed in the bottom wall thereof; a microneedle device seated in the opening of the housing in such a fashion as to be hermetically sealed with the bottom wall of the housing; a drug-containing capsule mounted in the housing | 02-24-2011 |
20110098651 | DISSOLVABLE MICRONEEDLE ARRAYS FOR TRANSDERMAL DELIVERY TO HUMAN SKIN - A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion. | 04-28-2011 |
20110137254 | Manufacturing method for a porous microneedle array and corresponding porous microneedle array and corresponding substrate composite - A manufacturing method for a porous microneedle array includes: forming a plurality of porous microneedle arrays, each having at least one microneedle and a porous carrier zone lying beneath it on the face of a semiconductor substrate; forming an interlayer between a non-porous residual layer of the semiconductor substrate located on the back side of the semiconductor substrate and the carrier zone, which has greater porosity than the carrier zone; detaching the residual layer from the carrier zone by breaking up the interlayer; and separating the microneedle arrays into corresponding chips. | 06-09-2011 |
20110137255 | Medical Skin Mountable Device - A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner. | 06-09-2011 |
20110144591 | Transdermal Delivery Device - The present invention relates generally to a transdermal delivery device which is suitable for the transdermal delivery or removal of substances, and in particular relates to a transdermal delivery device having a support and a plurality of microneedles projecting outwardly from the support, at least one microneedle including a channel positioned on the exterior surface which aligns with at least one aperture being formed in the support. | 06-16-2011 |
20110172605 | MICRONEEDLE, MICRONEEDLE ARRAY AND PRODUCTION METHOD THEREFOR - The present invention provides a microneedle, comprising a shaft of a monocrystalline material having at least three was which are formed by a crystal plane of the monocrystalline material; and a tip connected to an end of the shaft comprising at least three walls which are formed by a crystal plane of the material. The material is preferably silicon. Two of the walls of the tip are formed by the same crystal planes as two walls of the shaft. These two walls are formed by a <111> crystal plane. Preferably, three walls of the tip are formed by a <111> crystal plane. | 07-14-2011 |
20110196308 | Device and a system for delivery of biological material - The present application provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological material through a needle or a micro-needle or micro-needles or biodegradable microneedles. | 08-11-2011 |
20110196309 | Multifunctional Device And Methods For Tissue Surgery - A multifunctional device featuring a cartridge having first and second ports; first and second chambers which have outlets disposed at proximal ends connected to tubes that bifurcate to form intake lines and deposit lines, wherein one-way valves are disposed in the intake and deposit lines, wherein pistons are disposed in the chambers which oscillate between moving toward the proximal or distal end, when the piston moves toward the distal end a material can be drawn into the chamber and when the piston moves toward the proximal end the material can be pumped out of the chamber; and wherein the intake lines are formed from bifurcation of a main intake fine fluidly connected to the first port; wherein the deposit lines feed into a main deposit line fluidly connected to the second port; wherein the device can pump material from the first port to the second port. | 08-11-2011 |
20110218497 | MULTIPLE-INJECTION MEDICAL APPARATUS - A multiple-injection medical apparatus for injection of a medical fluid is described. The multiple-injection medical apparatus comprises a disk-like support member, a plurality of substantially radial needles housed in the disk-like support member, a chamber connected to one or more of the needles and suitable for containing the medical fluid to be injected, and a means for continuously refilling the chamber with the medical fluid after each injection. | 09-08-2011 |
20110245776 | DELIVERY DEVICE - A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body. | 10-06-2011 |
20110251561 | TRANSDERMAL ADMINISTRATION DEVICE - The transdermal administration device of the present invention includes: a device body including a needle form body, which includes a plurality of microneedles formed on a surface thereof and is provided with a fluid passage hole through the front surface to a back surface thereof, and a medical fluid filling section for providing a medical fluid to the back surface of the needle form body; a stratum corneum peeling system; and a connection section for connecting the device body and the stratum corneum peeling system,
| 10-13-2011 |
20110251562 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 10-13-2011 |
20110264048 | TRANSFER DEVICE FOR TRANSFERRING A SUBSTANCE BETWEEN THE DEVICE AND A SUBJECT - A micro-needle delivery device ( | 10-27-2011 |
20110276003 | INTEGRATED MICRONEEDLE ARRAY AND A METHOD FOR MANUFACTURING THEREOF - The invention relates to a method of manufacturing of a microneedle array comprising the steps of selecting a soft production mold comprising a set of microscopic incisions defining geometry of the microneedles, said soft production mold being capable of providing the microneedle array integrated into a base plate; using a filler material for abundantly filling the microscopic incisions of the soft production mold thereby producing the microneedle array with pre-defined geometry integrated into the base plate; wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array, a composition comprising a microneedle array, a system for enabling transport of a substance through a barrier and a system for measuring an electric signal using an electrode. | 11-10-2011 |
20110276004 | MICRONEEDLE CAP SYSTEM ENABLING ADJUSTMENT OF OUTFLOW RATE OF ACTIVE SUBSTANCE - The present invention relates to a microneedle cap system to be mounted to a container containing an active substance. The system comprises a container cap unit and a microneedle unit, which, among others, allows the active substance to be delivered in a desired amount. | 11-10-2011 |
20110288484 | METHOD AND ASSOCIATED APPARATUS FOR COATING PROJECTIONS ON A PATCH ASSEMBLY - A method of coating projections on a patch, the method including, selecting a coating solution viscosity, the viscosity being selected to reduce the degree of capillary action between the patch and the coating solution and immersing at least part of tips of projections in a coating solution having the selected coating solution viscosity such that substantially only tips of the projections are coated. | 11-24-2011 |
20110288485 | MICRONEEDLE DEVICE - Provided is a microneedle device having a microneedle base and microneedles capable of piercing the skin and being from 300 μm to 500 μm in height disposed on the base, where at least a part of the surface of the microneedles and/or the microneedle base is coated with a coating agent containing an active ingredient and a coating carrier, and a blending ratio of the active ingredient and the coating carrier is 10:0.1 to 1:10. Also provided are methods for administering active ingredients efficiently and simply through the skin using the microneedle device. | 11-24-2011 |
20120004614 | Production Process for a Microneedle Arrangement and Corresponding Microneedle Arrangement and Use - A production process for a microneedle arrangement and a corresponding microneedle arrangement as well as a use for it is disclosed. The process has the following steps: forming an etching mask in grid form, with grid bars with corresponding grid crossing regions and grid openings in between on a substrate; carrying out an etching process to form the microneedle arrangement on the substrate using the etching mask and removing the etching mask. The etching mask in grid form has at least some of the grid crossing regions flat reinforcing regions, which extend beyond the grid bars. | 01-05-2012 |
20120016308 | LOW-PRESSURE PACKAGING FOR FLUID DEVICES - The present invention generally relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin, including packaging associated with such systems. Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers, e.g., having an internal pressure less than atmospheric pressure. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein. In some embodiments, the pressure of the environment may be the same as or less than that of vacuum chambers contained within the device. Other aspects of the invention are generally directed to methods of creating such devices, techniques for using such devices, kits involving such devices, and the like. | 01-19-2012 |
20120016309 | MICROARRAY DEVICE - A device is provided which is suitable for delivering at least one nanoparticle(s) to a subject. The device can be used to deliver a variety of nanoparticles, for example, therapeutic agents, directly through the outer layers of the skin without passing completely through the epidermis of the subject. Thus the device can be used to deliver therapeutic agents to a predetermined depth and avoid disturbing the pain receptors in the skin. Thus the device can be used to deliver agents, including therapeutic agents, in a non-invasive manner. A method of fabricating devices with associated nanoparticles is also provided. | 01-19-2012 |
20120029434 | APPLICATOR FOR MICRONEEDLE ARRAY - Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced. | 02-02-2012 |
20120041373 | Needle Changing Apparatus - An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle. | 02-16-2012 |
20120041374 | NEEDLE UNIT AND DERMATOLOGICAL LIQUID INJECTION APPARATUS USING SAME - The present invention relates to a needle unit for injecting liquids such as medicine or tattooing pigment spread to a skin, into the skin, and a dermatological liquid injection apparatus using the same. The present invention includes a body unit including a driving device, a cam member rotated by the driving device, and a connecting member reciprocally driven by the cam member; a needle unit detachably mounted to a front end of the body unit; and a rubber member installed to the needle unit, for blocking blood and liquid mixture which are discharged from a skin of a patient and flow into the needle unit, from flowing to the body unit during a medical procedure. | 02-16-2012 |
20120059326 | Microneedle Unit Capable of Controlling Fluid Delivery - Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member. | 03-08-2012 |
20120071832 | ACCESS SHEATH AND NEEDLE ASSEMBLY FOR DELIVERING THERAPEUTIC MATERIAL - Medical device ( | 03-22-2012 |
20120078188 | NEURAL DRUG DELIVERY SYSTEM WITH FLUIDIC THREADS - A neural drug delivery system with fluidic threads implantable into tissue, including: a plurality of fluid delivery conduits configured to transport fluid and having an array of fluid delivery ports through which the fluid is selectively released; a plurality of port gates each including a mesh structure coupled to a corresponding fluid delivery port and coated with an electroactive polymer; a voltage source providing a conductive signal; and an interconnect network that carries the conductive signal to the port gates. In response of the electroactive polymer to the conductive signal, each port gate is selectively operable between a closed mode that prevents transfer of fluid through its corresponding fluid delivery port to the tissue, and an open mode that allows transfer of the fluid through its corresponding fluid delivery port to the tissue. | 03-29-2012 |
20120078189 | NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET AND METHOD FOR MANUFACTURING NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET - A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions. | 03-29-2012 |
20120083741 | DELIVERY DEVICE - A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body. | 04-05-2012 |
20120089095 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 04-12-2012 |
20120109065 | Transdermal Fluid Delivery Device - A transdermal fluid delivery device includes a housing defining a longitudinal axis and having a proximal end and a distal end. The housing defines a passageway extending longitudinally therethrough. A fluid reservoir is disposed at the proximal end of the housing in communication with the passageway of the housing and is adapted for retaining a fluid therein. A base member is positioned at the distal end of the housing. A microneedle assembly including a plurality of microneedles extending distally therefrom is also provided. The microneedle assembly is selectively moveable with respect to the housing between a retracted position, wherein the microneedles are disposed within the housing, and an extended position, wherein the microneedles are advanced distally to penetrate the base member and extend distally therefrom for puncturing the patient's epidermis and delivering the fluid into the patient's bloodstream. | 05-03-2012 |
20120109066 | WEARABLE DRUG DELIVERY DEVICE HAVING SPRING DRIVE AND SLIDING ACTUATION MECHANISM - A drug delivery device is provided. The drug delivery device includes a drug reservoir in fluid communication with a microneedle array. The drug delivery device has a sliding actuation mechanism that may be activated by a button or lever. Actuation of the drug delivery device inserts the microneedle array into the skin of a subject and causes a piston to compress the drug reservoir, thereby delivering the drug through the microneedle array to the subject. | 05-03-2012 |
20120109067 | TRANSDERMAL ADMINISTRATION DEVICE - The transdermal administration device of the present invention includes: a needle support with a plurality of microneedles formed at a tip portion thereof; a holder with the needle support placed therein, allowing the needle support to protrude itself therefrom and retract therein; and a cap for covering the microneedles, and further includes: a spring member placed between the needle support and the holder, for biasing the needle support in a protruding direction; an engaging portion at a base of the needle support; and an engaged portion capable of engaging the engaging portion, formed in the holder, where the engaging portion of the needle support can be locked with the engaged portion of the holder when the needle support is retracted in the holder. | 05-03-2012 |
20120116314 | TRANSDERMAL PATCH WITH PULL-TAB ACTUATED ENERGY STORAGE DEVICES - A transdermal patch can include a drug source, a porator, and an energy storage device on-board the patch. Conductive contact terminals can extend from the energy storage device for connection to an external source of power. The porator operates free of any concurrent connection to any external source of power. A switch can be used to make the selective electrical connection between the porator and the energy storage device. The switch can be arranged to respond to a manual user action after the patch has been adhered to skin, including separation of the porator from a remainder of the patch. Optionally, a series of switches can make electrical connections between the porator and respective individual energy storage devices. | 05-10-2012 |
20120123341 | MONITORING SYSTEM FOR MICRONEEDLE DRUG DELIVERY - The invention relates to a microneedle drug monitoring system, and also a microneedle device when provided with the drug monitoring system, comprising the selective and sequential coating of microneedles with layers of indicator material and therapeutic agent. | 05-17-2012 |
20120130313 | NEEDLE CARTRIDGE FOR MEDICATION INJECTION DEVICE - A cartridge with injection needles for an injection device. The cartridge includes a plurality of injection needle assemblies, each including a hub, mounted to be shiftable in cavities of a needle assembly support. A hub ledge having a drive member engageable push surface projects within a gap between a first hub portion and a second hub portion. Driving engagement of the push surface by an injection device drive member shifts the needle assembly from a retracted position to an injection position, during which shifting the second hub portion moves relative to the first hub portion. A pull surface on the second hub portion is engagable with the drive member for lifting the needle assembly from the injection position. | 05-24-2012 |
20120136312 | MICRONEEDLE ARRAY - Relations between crystallinity and performance of a biodegradable resin, between weight-average molecular weight and strength thereof, and between weight-average molecular weight and performance thereof were clarified. As a result thereof, when a microneedle array was provided with microneedles containing noncrystalline polylactic acid which had a weight-average molecular weight of 40,000 to 100,000, it was possible to obtain a microneedle array which could maintain its functional performance. | 05-31-2012 |
20120184914 | DISPOSABLE INJECTION DEVICE - An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the .locking mechanism prevents the needle from being placed in the injection position. | 07-19-2012 |
20120253286 | ARRANGEMENT FOR DELIVERING A FLUID MEDICAMENT - The invention relates to an arrangement for delivering a fluid medicament, the arrangement comprising a medicament container that comprises an array of separated reservoirs. Each reservoir comprises a defined charge of a fluid medicament and is separately dischargeable. The reservoirs are flexible and connected by a connecting element. The arrangement further comprises a dosage apparatus comprising a releasing actor designed to activate the release of the charge of fluid medicament from a reservoir to a needle. The dosage apparatus comprises a transportation arrangement designed to provide the releasing actor with reservoirs to be released, or designed to move the releasing actor to a reservoir to be released next. | 10-04-2012 |
20120265145 | SOLUBLE MICRONEEDLE - Microneedle comprising a distal part made of a soluble material, characterized by the fact that said distal part comrises a skeleton. | 10-18-2012 |
20120283642 | MICRONEEDLE DEVICE - A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device ( | 11-08-2012 |
20120316503 | Transdermal Device Containing Microneedles - The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass. | 12-13-2012 |
20130012882 | PROTEOGLYCAN-CONTAINING MICRONEEDLE ARRAY - An object of the present invention is to provide a novel microneedle array that has ( | 01-10-2013 |
20130030374 | MICRONEEDLE AND METHOD OF MANUFACTURING MICRONEEDLE - A method of manufacturing a microneedle including forming a plurality of first linear grooves on a substrate in parallel to one another along a first direction using grinding and forming a plurality of second linear grooves on the substrate in parallel to one another in a second direction intersecting the first direction using grinding. At least one of the forming of a plurality of first linear grooves and the forming of a plurality of second linear grooves includes forming first stage grooves using a first dicing blade; and processing the first stage grooves by tracing the first stage grooves using a second dicing blade having a side surface different from that of the first dicing blade to thereby form second stage grooves. | 01-31-2013 |
20130072874 | DEVICE HAVING ARRAY PROVIDED WITH FINE PROTRUSIONS | 03-21-2013 |
20130123706 | CATHETER SYSTEM FOR DELIVERY OF TUMESCENT ANESTHESIA - An intravascular catheter for placement in a vessel and for injecting anesthetic or other drug into tissues proximate the catheter distal tip. | 05-16-2013 |
20130123707 | AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS - Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s | 05-16-2013 |
20130131597 | CARTRIDGE FOR A BLOOD VESSEL ACCESS SYSTEM AND DEVICE - A cartridge for use with a blood vessel access system and device. The cartridge includes a slideable needle mount and a slideable cannula mount, the slideable needle mount having a needle in slideable connection with a lumen of a cannula held by the needle mount. The slideable needle mount and the slideable cannula mount are removeably attachable with separate moveable platforms of a needle injector that is pivotally attached to a handheld ultrasound transceiver in signal communication with a computer processing unit connected with a monitor. Upon insonification of a patient's vasculature using the handheld ultrasound transceiver pressed against the surface of the patient, needle injection and subsequent cannulation of a targeted blood vessel appearing on the monitor is accomplished by deploying the needle and cannula from the cartridge via motorization of the moveable platforms that is initiated by the user operating a controller on the device's needle injector. | 05-23-2013 |
20130131598 | METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS - Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. | 05-23-2013 |
20130144217 | INJECTION MOLDED MICRONEEDLE ARRAY AND METHOD FOR FORMING THE MICRONEEDLE ARRAY - Disclosed are injection molded devices including microneedles on a substrate base. The microneedles may include a plurality of nano-sized structures fabricated thereon. The molds used to form the microneedles are assembled from a plurality of mold segments, each defining portions of the microneedles. Upon assembly of the multiple mold segments, microneedle negative cavities are formed. The molds may be used in an injection molding process to form microneedle arrays. Devices may be utilized for interacting with a component of the dermal connective tissue. | 06-06-2013 |
20130158482 | RAPID DELIVERY AND/OR RECEIVING OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 06-20-2013 |
20130165861 | COMPOSITE MICRONEEDLE ARRAY INCLUDING NANOSTRUCTURES THEREON - Disclosed are composite microneedles arrays including microneedles and a film overlaying the microneedles. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component. | 06-27-2013 |
20130178801 | OTIC FORMULATIONS, METHODS AND DEVICES - The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, and antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a fluoroquinolone, a triazole antifungal, a thiocarbamate antifungal, a corticosteroid and a polyene antifungal, as well as a thickener such that the formulation, upon applying to the infected ear canal, gels and remains in the ear canal, continuously releasing the active ingredients for several days, achieving consistent complete (98-100%) clinical resolution of otomycosis and otitis externa in a single application. | 07-11-2013 |
20130218083 | DEVICE FOR APPLYING MICRONEEDLE ARRAY TO SKIN - Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle. | 08-22-2013 |
20130218084 | JIG FOR MICRONEEDLE ARRAY PLACEMENT AND MICRONEEDLE ARRAY DEVICE - The invention relates to a jig for microneedle array placement that is provided with a main jig body with through holes through which the microneedles of the microneedle array will pass and a guiding part that guides the microneedle array to be incorporated into the main jig body and leads the microneedles into the through holes, and a microneedle array device using the jig for microneedle array placement. The invention prevents the deformation of the skin surface during puncture and allows penetration of the microneedles to the prescribed depth under the skin. | 08-22-2013 |
20130274673 | INTRAVASCULAR ABLATION CATHETER WITH ENHANCED FLUOROSCOPIC VISIBILITY - A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery. | 10-17-2013 |
20130274674 | INTRAVASCULAR ABLATION CATHETER WITH PRECISION DEPTH OF PENETRATION CALIBRATION - A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery. | 10-17-2013 |
20130296790 | MICRONEEDLE - Provided are a microneedle and a microneedle array which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient,
| 11-07-2013 |
20130296791 | MEDICATION DELIVERY ASSEMBLY - A drug delivery assembly for use in association with an outlet port of an injection device, the assembly including a connector for association with the outlet port of the injection device, a skin interface element including a fluid flow channel in fluid connection with at least one hollow penetrating element deployed for penetrating into a biological barrier and a shield deployed to prevent inadvertent contact with said hollow penetrating element prior to use. The shield being retained in engagement with at least one of the connector and the skin interface element. The skin interface element is mechanically engaged with the connector so as to be displaceable relative to the connector between an inactive position and an active position. The motion of the skin interface element relative to the connector from the inactive position to the active position is effective to disengage retention of the shield. | 11-07-2013 |
20130338596 | MICRONEEDLE PATCH APPLICATOR - A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch. | 12-19-2013 |
20130338597 | MICRONEEDLE PATCH APPLICATOR SUPPORT - A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch. | 12-19-2013 |
20130345638 | MULTIPLE DRUG DELIVERY DEVICE - A drug delivery device is provided. The device is a wearable active transdermal drug delivery device which facilitates drug delivery using one or more vaccine cartridges having microneedles as the point of drug delivery. The device may be used to perform multiple vaccine deliveries to the intradermal layer of a patient. | 12-26-2013 |
20140005606 | EMBEDDABLE MICRO-NEEDLE PATCH FOR TRANSDERMAL DRUG DELIVERY AND METHOD OF MANUFACTURING THE SAME | 01-02-2014 |
20140046262 | MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS - The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer. | 02-13-2014 |
20140052067 | DEVICES FOR PUNCTURING FOR A HUMAN OR ANIMAL BODY'S MEMBRANE - Device for puncturing a membrane of a human or animal body so as to introduce a liquid formulation thereinto, provided with a patch ( | 02-20-2014 |
20140066855 | INTEGRATED MICRONEEDLE ARRAY AND A METHOD FOR MANUFACTURING THEREOF - The invention relates to a method of manufacturing of a microneedle array comprising the steps of selecting a soft production mold comprising a set of microscopic incisions defining geometry of the microneedles, said soft production mold being capable of providing the microneedle array integrated into a base plate; using a filler material for abundantly filling the microscopic incisions of the soft production mold thereby producing the microneedle array with pre-defined geometry integrated into the base plate; wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array 16, a composition comprising a microneedle array, a system for enabling transport of a substance through a barrier and a system for measuring an electric signal using an electrode. | 03-06-2014 |
20140128810 | PERCUTANEOUS MEDICATION DEVICE AND NEEDLE FORMATION USED FOR THE DEVICE - A percutaneous medication device according to the present invention comprises: a syringe into which a medical liquid is filled; and a needle formation attached to a tip of the syringe; where: the needle formation comprises a plurality of needles protruding from a surface of a tip of the needle formation; a tip of the needle is cut diagonally with respect to the longitudinal direction of the needle; a discharge opening formed at the tip of each needle is facing substantially opposite from the center direction of the needle formation; and a pitch between the adjacent needles is 1 mm to 10 mm. | 05-08-2014 |
20140128811 | Microneedle Arrays - Microneedle arrays made by an injection molding process that uses ultrasonic energy to assist flow of polymer melt into a mold cavity, said microneedles having a high proportion (at least 60%) of fill, i.e., completely formed microneedles across the array. Microneedle array can be on a base or land no more than 250 μm thick. | 05-08-2014 |
20140236089 | SYSTEM FOR TRANSPORTING FLUID ACROSS OR INTO A BIOLOGICAL BARRIER, DEVICE AND CAPSULE AS PART OF THE SYSTEM - The invention relates to a system ( | 08-21-2014 |
20140236090 | INTEGRATED MICRONEEDLE ARRAY DELIVERY SYSTEM - The present disclosure provides low-profile systems and methods for delivering a microneedle array. A delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate a stored energy device. The stored energy device can be designed to store a predetermined amount of potential energy that is greater or substantially greater than the energy necessary to release said energy. As the stored energy device is potentially capable of releasing substantially more energy than is required to cause the release, the amount of normal force applied to the skin can be minimized while sufficient application velocity is still generated. | 08-21-2014 |
20140243747 | APPLICATOR - An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator | 08-28-2014 |
20140257187 | INTEGRATED MICRONEEDLE ARRAY DELIVERY SYSTEM - The present disclosure provides a low-profile system and methods for delivering a microneedle array. The delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate an applicator device. The carrier assembly is at least releasably secured to the housing and it is typically not attached or otherwise fixed to any portion of the applicator device. | 09-11-2014 |
20140257188 | DELIVERY DEVICE - A device for delivery of material to a biological subject, the device including a base and a number of projections extending from the base, each projection including a tip for penetrating tissue of the biological subject, at least a portion of at least one of the projections being coated with a non-liquid coating including the material. At least the tip of at least one of the coated projections may have a convex effective profile. The device may be for delivery of material to a dermal layer of the biological subject. In another aspect an applicator for applying the device to the biological subject applies a preload force to the tissue such that the force at least partially compresses a subcutaneous tissue layer of the biological subject prior to application of the device, and applies the device with a predetermined velocity, wherein tissue stiffness is maintained and/or the projections penetrate the tissue to a predetermined depth. | 09-11-2014 |
20140257189 | MICRONEEDLE DEPOSITION METHOD - The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same. | 09-11-2014 |
20140257190 | Disposable Array-Type Micro Injection Needle Head And Pre-Filling Injector Thereof - The invention discloses a disposable array-type micro injection needle head which comprises a lower needle seat which is configured as a cylindrical column opening at one end and having a top cap at the other end and which is configured to be connected with an injection reservoir; an upper needle seat which is located above the top cap of the lower needle seat with a cavity formed between the upper needle seat and the top cap; a through-hole formed in the top cap which is configured for communicating the cylindrical column with the cavity, wherein a pipetting needle is mounted in the through-hole which has one end communicated with the cavity and the other end located in the cylindrical column and which is configured for extracting injection from the injection reservoir into the cavity; and at least two needle tubes mounted in the upper needle seat, each of which has one end comprising a needle tip for puncturing and for injecting the injection and the other end for mounting on the upper needle seat and for communicating with the cavity. The needle head can be used directly on existing insulin pen, or the cylindrical column can be provided inside it with an injection reservoir to form a disposable prefilled syringe. By using a plurality of thin, short needle tubes for injecting simultaneously, vertical hypodermic injection of medicines such as insulin can be preformed rapidly, leakproof, painlessly, safely and conveniently at various sites of a human body, without needing to pinch skin, while a potential trouble that the medicines be injected into muscles can be avoided. Patient adherence to the treatment regimen and the treatment effect are improved. | 09-11-2014 |
20140296789 | Multi-Lumen Needle and Catheter Guidance System - A multi-lumen needle and catheter guidance system is provided and includes: a multi-lumen needle including a pair of rectangular lumens, the pair of rectangular lumens extending longitudinally within and through a shaft of the multi-lumen needle from a proximal end of the multi-lumen needle to a distal end of the multi-lumen needle, the pair of rectangular lumens diverging in opposite directions and ending at a pair of rectangular apertures formed on opposing sides of the distal end of the multi-lumen needle; and a pair of rectangular catheters for insertion into and through the pair of lumens, wherein distal ends of the rectangular catheters are configured to pass out of the distal end of the multi-lumen needle in opposing directions through the pair of rectangular apertures. | 10-02-2014 |
20140296790 | HIGH FLOW RATE DUAL RESERVOIR PORT SYSTEM - Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed. | 10-02-2014 |
20140330209 | MICRONEEDLE ARRAY APPLICATOR DEVICE AND METHOD OF ARRAY APPLICATION - An applicator device including a housing, an impactor for impacting a microneedle array and accelerating the microneedle array toward the target site, wherein the impactor is capable of moving along an arcuate path to move the microneedle array toward the target site. Also, an applicator device including a housing, a patch applicator pivotally supported by the housing, and a torsion spring. The patch applicator has a retaining portion and a patch contacting portion, and the patch contacting portion is capable of moving along a substantially arcuate path between a first position and a second position. The torsion spring is capable of biasing the patch applicator relative to the housing. | 11-06-2014 |
20140343499 | MICRONEEDLE DEVICE INCLUDING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID AND METHODS OF MAKING AND USING THE SAME - A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine. | 11-20-2014 |
20140350472 | DISSOLVABLE MICRONEEDLE ARRAYS FOR TRANSDERMAL DELIVERY TO HUMAN SKIN - A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion. | 11-27-2014 |
20140371679 | DRUG DELIVERY APPARTAUS - Percutaneous access apparatus is described that includes a percutaneous fluid access device having an extracorporeal portion, one or more ports accessible from the extracorporeal portion and a septum for sealing each port. A connector device having one or more hollow needles is attachable to the percutaneous fluid access device. The apparatus also includes an attachment mechanism for attaching the connector device to the extracorporeal portion and an actuation mechanism that, after the connector device has been attached to the extracorporeal portion, can be used to drive the one or more hollow needles through the septum to establish fluid communication between the one or more hollow needles and the one or more ports. The apparatus may be used for neurosurgery applications. | 12-18-2014 |
20140378906 | PERI-VASCULAR TISSUE ABLATION CATHETER WITH MECHANICAL SUPPORT STRUCTURES - An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. | 12-25-2014 |
20150025468 | EXTERNAL END DEVICE FOR PERMANENT CATHETERS SUITABLE FOR ISOLATING A LIQUID FLOW - An external end device for permanent catheters suitable for isolating a liquid flow from the environment has a body ( | 01-22-2015 |
20150025469 | Revolving Needle Magazine - A needle magazine ( | 01-22-2015 |
20150038911 | MICRONEEDLE ADAPTER FOR DOSED DRUG DELIVERY DEVICES - An adapter ( | 02-05-2015 |
20150080802 | Novel Method To Fabricate Polymeric Microneedles - The present disclosure relates generally to microneedle devices and methods for fabricating microneedles from a biocompatible polymer using photolithography. More particularly, aspects of the present disclosure are directed to the fabrication of microneedle devices using a biocompatible polymer (biopolymer) by way of biocompatible, essentially biocompatible, or substantially biocompatible fabrication techniques. | 03-19-2015 |
20150088074 | CATHETER HUB - A catheter hub includes a distal assembly including a distal hub member adapted to be fixedly attached to an outer catheter and a proximal assembly including a proximal hub member adapted to be fixedly attached to an inner catheter disposed through the outer catheter. An elongate member connects the proximal and distal assemblies such that the proximal and distal assemblies can translate longitudinally relative to one another. | 03-26-2015 |
20150105729 | Atraumatic Medical Device - A catheter with a spring tip that facilitates atraumatic initial placement and also continues to protect tissue contacted by the catheter device subsequent to the initial placement. The spring tip is shock-absorbing and axially compliant and allows enhanced use of various devices in conjunction with the tip such as bioptomes, electrodes, needles, flushing catheters, delivery catheters, and the like. The atraumatic shock-absorbing tip could include conductive or non-conductive materials. | 04-16-2015 |
20150112269 | OPERATIONAL INSTRUMENT FOR FLUID INJECTOR USING MULTI-MICRONEEDLE DEVICE - An operation tool for a fluid injector includes an outer cylinder having a housing extending from a first open end to a second open end, and a selective transfer mechanism provided on the outer cylinder. The selective transfer mechanism moves the fluid injector from an initial position to a first protrusion position and then to a second protrusion position in the housing of the outer cylinder. When the fluid injector is at the initial position, the multi-microneedle device has microneedles retracted from the first open end and positioned inside the housing, when the fluid injector is at the first protrusion position, the microneedles are protruded out to a first distance from the first open end, and when the fluid injector is at the second protrusion position, the microneedles are protruded out to a second distance from the first open end. The second distance is shorter than the first distance. | 04-23-2015 |
20150126937 | SELF-INJECTION MECHANISM FOR USE ON SKIN - The present invention relates to a self-injection mechanism that causes a solution ( | 05-07-2015 |
20150133866 | OPERATION TOOL FOR FLUID INJECTOR USING MULTI-MICRONEEDLE DEVICE - An operation tool includes a mechanism sequentially moving the injector in a space of an outer cylinder among an initial position in which needles of a main body of the device are retracted inside the space, a first position in which the needles protrude to the outside by a first distance, and a second position in which needles protrude to the outside by a second distance shorter than the first distance. Fluid flows from the injector through the needles in the second position. The mechanism has a unit forcing the injector toward the initial position by a magnetic force, first and second stoppers which can be selectively extended/retracted with respect to the outer peripheral wall of the outer cylinder, and an engaging portion which is selectively engaged with these stoppers on the outer peripheral wall of the injector and selectively arranging the injector in the above three positions. | 05-14-2015 |
20150141924 | Hollow Silica Glass Microneedle Arrays and Method and Apparatus for Manufacturing Same - A novel array of hollow silica glass microneedles is provided. The array is prepared from a silica dispersion. A novel apparatus is provided comprising a negative mold component having tapered openings therein and a positive mold component having positive elements that are received within the tapered openings of the negative mold component. An assembly is prepared of the negative mold component and the positive mold component, with an aqueous silica dispersion received within the space between the outer surface of the positive elements and the inner surface of the openings. The assembly is heated to remove air and water vapors from the silica dispersion, then the assembly is further heated to sinter the remaining silica to silica glass. The sintered silica glass when removed from the mold components is in the form of an array of microneedles. | 05-21-2015 |
20150306363 | ARTICLE WITH HOLLOW MICRONEEDLES AND METHOD OF MAKING - The present application provides articles ( | 10-29-2015 |
20150314117 | APPLICATOR - An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring. | 11-05-2015 |
20150320990 | ADHESIVE ASSEMBLIES AND MICRONEEDLE INJECTION APPARATUSES COMPRISING SAME - Adhesive assemblies and microneedle injection apparatuses comprising same. The apparatus ( | 11-12-2015 |
20150335827 | A Needle Device - The invention relates to a needle device which is made from a housing ( | 11-26-2015 |
20150374967 | Microneedle Array - A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction. | 12-31-2015 |
20160008535 | APPARATUS FOR TREATING A TENNIS ELBOW BY MEANS OF PERCUTANEOUS INTERVENTION, AS WELL AS A HOLDER FOR USE WITH SUCH AN APPARATUS | 01-14-2016 |
20160051807 | Method and Device for Controlling Drug Pharmacokinetics - Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling. | 02-25-2016 |
20160082239 | MICRONEEDLE ARRAY AND MICRONEEDLE ARRAY DEVICE - The objective of the present invention is to provide: a microneedle array which is capable of inserting a microneedle into the skin at an oblique angle and thereby, upon injection with the microneedle, is capable of both relieving the patient's pain and preventing a drug solution from leaking; and a microneedle array device which comprises the microneedle array. To this end, a microneedle array comprises: a microneedle unit that includes microneedles; and a microneedle unit support member that includes an opening, guides both ends of the microneedle unit through inclined grooves, and arranges tips of the microneedles so as to project through the opening in an inclined manner. | 03-24-2016 |
20160082241 | MICRONEEDLE INJECTION APPARATUS COMPRISING AN INVERTED ACTUATOR - A microneedle injection apparatus ( | 03-24-2016 |
20160101272 | MICRONEEDLE PATCH APPLICATOR SYSTEM - A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch. | 04-14-2016 |
20160114144 | HOLLOW NEEDLE DEVICE - A hollow needle device includes a main body having a first surface on which hollow acicular bodies are formed and a second surface opposite to the first surface, a main body supporting member having an opening that accommodates the main body and including a drop-out prevention mechanism for holding the main body that has the hollow acicular bodies being protruded from one end of the opening, an injector supporting member disposed detachably in the opening of the main body supporting member, and a liquid-tight structure that establishes liquid tightness between the injector supporting member and an inner surface that defines the opening in the main body supporting member. The injector supporting member has a connection hole to which a protrusion of an injector is detachably connected liquid tightly to guide an injection solution supplied from the injector into the opening via the protrusion of the injector. | 04-28-2016 |
20160121091 | MICRONEEDLE INJECTION APPARATUS COMPRISING A DUAL COVER - A microneedle injection apparatus comprising a dual cover. The apparatus can include a housing having a base and a cavity; a microneedle array comprising a first side comprising a plurality of microneedles; and a microneedle array holder configured to hold a microneedle array and located in the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include a cover ( | 05-05-2016 |
20160121092 | MICRONEEDLE UNIT - A microneedle unit includes a liquid holder, a microneedle, and a support member. The liquid holder has an enclosure that holds liquid including a substance to be administered. The microneedle has a base body and protrusions extending from the surface of the base body. The protrusions are of a hardness sufficient to pierce the liquid holder. The support member supports the base body in a state such that the microneedle is arranged at a position in which the tips of the protrusions and the enclosure holding the liquid are opposed to each other with a gap provided therebetween. The tips of the protrusions can be displaced to a position where the tips of the protrusions penetrate through the liquid holder in response to an external force applied to the base body. | 05-05-2016 |
20160129164 | MICRO-NEEDLE AND MICRO-NEEDLE PATCH - Provided are micro-needles and a micro-needle patch for transdermal delivery of a pharmaceutical, medical, or cosmetic substance. The micro-needle may include a biocompatible matrix having a micro-needle-like shape; and porous particles provided at at least a portion of a surface or the interior of the biocompatible matrix. | 05-12-2016 |
20160136405 | Applicator - An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space. | 05-19-2016 |
20160136408 | MICRONEEDLE AND METHOD FOR MANUFACTURING MICRONEEDLE - A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate. | 05-19-2016 |
20160144160 | APPLICATOR - An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface. | 05-26-2016 |
20160151616 | ARTICLE COMPRISING A MICRONEEDLE | 06-02-2016 |
20160158511 | FABRICATION PROCESS OF PHASE-TRANSITION MICRONEEDLE PATCH - The application discloses a method to fabricate microneedle patches, comprising a) casting (painting and pasting) an aqueous polymer solution on a mold of array of micro-holes which is made of porous materials; b) sucking the polymer solution into the micro-holes by applying vacuum at the back of the mold; d) freezing and thawing the casted polymer solution to induce gelation; and e) drying the gelled polymer solution. Specifically, the present invention describes a process and composition of polymeric microneedlepatch which overcomes the limitations of existing microneedles systems and may be used for transdermal delivery system for therapeutics and other applications. | 06-09-2016 |
20160158512 | MICRONEEDLE ARRAY AND MICRONEEDLE ARRAY MANUFACTURING METHOD - The purpose of the present invention is to provide: a microneedle array that does not readily break during puncture and thereby improves the reliability of puncturing, the microneedle array being capable of administering the desired amount of the target substance; and a microneedle manufacturing method for manufacturing a microneedle array of such description. To achieve the above purpose, the invention is characterized in being provided with: a substrate; a plurality of microneedle base sections formed integrally in a protruding manner on the substrate; and microneedle end sections installed at the ends of the microneedle base sections to form microneedles and provided with in vivo solubility or biodegradability, the microneedle end sections holding the target substance, a recess for admitting the microneedle end sections being provided to the microneedle base sections, and a part of the microneedle end sections being admitted into the recess for admitting the microneedle end sections. | 06-09-2016 |
20160158515 | TRANSDERMAL THERAPEUTIC SYSTEM WITH PRESSURE GENERATING DEVICE - A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element | 06-09-2016 |
20160166820 | DEVICE WITH TRANSDERMAL THERAPEUTIC SYSTEM, AND POSITIONING AID AND PENETRATION AID | 06-16-2016 |
20160175573 | Microneedle Cartridge and Nosecone Assembly | 06-23-2016 |
20160192961 | METHODS AND APPARATUSES FOR SKIN TREATMENT USING NON-THERMAL TISSUE ABLATION | 07-07-2016 |