Entries |
Document | Title | Date |
20080200899 | METHODS FOR INTRAVASCULAR ENGRAFTMENT IN HEART - The invention relates to a method of engrafting donor cells into injured myocardium. The method includes delivering donor cells to a delivery site adjacent to and downstream of a chronic total occlusion and treating the chronic total occlusion. The delivery device may be a catheter with a wireguide that may be provided by a retrograde approach via an un-occluded artery or antegrade approach through the chronic total occlusion. The invention also relates to a method of treating injured myocardium and cell compositions for treatment of injured myocardium. | 08-21-2008 |
20080287915 | Tissue engineering system with scleral lens - A scleral lens is provided with a drug that is retained in the reservoir of fluid between the scleral lens and the cornea. This system can be used to deliver drugs not currently used because of poor bioavailability, to increase bioavailability of drugs used in patients already wearing a scleral lens, and to improve bioavailability in patients who are not currently wearing the lens. Dosing can be provided less frequently, thus decreasing the risk of non-compliance. | 11-20-2008 |
20080319417 | Cells isolation system for breast augmentation and reconstruction - A one-step real-time system for treating, reconstructing or augmenting a breast tissue defect in a patient comprising means for extracting adipose tissue, isolate adipocytes, process and re-inject stem and regenerative cells to the breast of the patient. | 12-25-2008 |
20090012498 | Gene therapy for treatment of heart failure - The present invention provides a medicament comprising a gene encoding an angiogenic cytokine for the treatment of acute myocardial infarction (AMI), idiopathic cardiomyopathy (ICM), dilated cardiomyopathy (DCM) or heart failure, to be given in combination with ventricular assist device (VAD). | 01-08-2009 |
20090012499 | NOVEL METHOD FOR TREATING CHRONIC SEVERE HEART FAILURE BY USING INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) - The present invention relates to novel method for treating chronic severe heart failure by using insulin-like growth factor-1 (IGF-1). More specifically, the present invention relates to method for improving cardiovascular function and symptoms in a patient with chronic severe heart failure by administering IGF-1 to the patient for a certain period, wherein no options for treating the disorder the patient remain other than heart transplantation. | 01-08-2009 |
20090076481 | Therapeutic angiogenesis for treatment of the spine - The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments. | 03-19-2009 |
20090088726 | SYMBIOTIC BIOLOGICAL SYSTEMS AS PLATFORMS FOR SENSING, PRODUCTION, AND INTERVENTION - Provided are systems and/or methods that facilitate sensing, detecting, or treatment of a condition or need of a living body using a genetically engineered symbiotic agent. | 04-02-2009 |
20090099548 | Device for Regenerating Adipose Tissue and Method for Utilizing Thereof - A device and method for regenerating adipose tissue has developed comprising: a washing container filled with an sterile solution for washing the adipose tissues; a syringe container holding syringes for washing and separating adipose tissues; injecting the wash solution and mixing the Bio-Gel, respectively; a second syringe container containing Bio-Gel syringes filled with materials to induce adipogenesis; and connector containers holding connectors for injection of the wash solution, and mixing of washed tissues and Bio-Gel. These containers are restrained in the kit by grooves in the bottom of the box. The box top holds needle containers for transplantation needles; and a protocol for fat transplantation, restrained by grooves. The kit minimizes risk of infection in fat transplantations using the patient's own tissues. It enables stable tissue transplantation as well as adipose tissue regeneration via use of aseptic/sterile implements, and a protocol for fat transplantation, solving the problems associated with conventional adipose tissue transplantation. | 04-16-2009 |
20090157046 | METHODS AND COMPOSITIONS FOR THE REPAIR AND/OR REGENERATION OF DAMAGED MYOCARDIUM USING CYTOKINES AND VARIANTS THEREOF - Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of cytokines, variants of cytokines, cardiac stem cells, or combinations thereof are disclosed and claimed. In addition, methods, compositions, and kits for forming coronary vasculature including the administration of cytokines, variants of cytokines, cardiac stem cells, or combinations thereof are described. In particular, administration of variants of hepatocyte growth factor, such as NK1, 1K1, and HP11, are useful for the repair and/or regeneration of damaged myocardium or formation of coronary vasculature. Methods of activating cardiac stem cells in vitro are also disclosed. | 06-18-2009 |
20090254065 | Simple method of transplanting injectable chordrocyte for autologous chondrocyte transplantation - A method of transplanting an injectable chondrocyte is developed for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, and injecting the resulting mixture into a damaged cartilage region. One 1 ml syringe is prepared by mixing 1 ml of a chondrocyte culture with white or light-yellow lyophilized powder (fibrinogen). A second 1 ml syringe is prepared by mixing 1 ml of chondrocyte culture with white lyophilized powder (thrombin), adding 0.1 cc of that mixture to the entire contents of two vials containing chondrocyte suspension, and mixing well. The two syringes are then mounted on a syringe stand, and a mixing tip is mounted to their tips. The contents are mixed in the mixing tip while injecting the resulting mixture into a damaged cartilage region of an animal. | 10-08-2009 |
20090281522 | METHODS OF INHIBITING SEIZURE IN A SUBJECT - The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject. | 11-12-2009 |
20090287185 | Cardiac Targeted Delivery of Cells - A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit. | 11-19-2009 |
20090299330 | Cellular Delivery Device - A cellular delivery device comprising a cellular carrier and an insertion device is provided. The cellular carrier includes at least one elongate strand of biocompatible material with a distal end and a proximal end. A stop member is connected to the proximal end of the elongate strand. The insertion device includes a needle attached to a hollow tubular body. The hollow tubular body is sized to receive the cellular carrier such that at least a portion of the elongate strand may be located within the hollow tubular body and the stop member protrudes from the proximal end of the hollow tubular body. | 12-03-2009 |
20090312746 | METHOD AND SYSTEM FOR PREPARING SOFT TISSUE FOR GRAFTING, ENHANCING GRAFTING RESULTS, AND GRAFTING AUTOLOGOUS FAT AND ADIPOCYTE DERIVED STEM CELLS TO SOFT TISSUE SUCH AS THE BREAST AND OTHER TISSUE DEFECTS - A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure. A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods. | 12-17-2009 |
20100010474 | METHODS AND APPARATUS FOR TREATING INFARCTED REGIONS OF TISSUE FOLLOWING ACUTE MYOCARDIAL INFARCTION - Apparatus and methods are provided for treating an infracted region of myocardium following acute myocardial infarction by reducing the rate of blood flow through infracted region, and then injecting a solution containing stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment into the effected region so that the stem cells become embedded therein and promote tissue regeneration. In a first embodiment, delivery of the stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment is accomplished using a catheter that relies upon antegrade flow through the coronary artery and a flow control catheter placed in the coronary sinus. In an alternative embodiment, the delivery catheter delivers the stem cells in a retrograde manner through the coronary sinus, and the delivery catheter further comprises an occlusion balloon for controlling outflow through the coronary sinus ostium. | 01-14-2010 |
20100042072 | Biological targeting compositions and methods of using the same - Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described. | 02-18-2010 |
20100063475 | DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE - Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue. | 03-11-2010 |
20100114069 | Methods, Systems, and Devices for Treating Intervertebral Discs Including Intradiscal Fluid Evacuation - Methods, systems, and devices for of treating intervertebral discs are disclosed. In one embodiment, a minimally invasive method of treating an intervertebral disc is provided. A contrast or imaging media is introduced into a nucleus of the intervertebral disc without removing any of the nucleus. The intervertebral disc is imaged with the contrast media within the nucleus. Then the contrast media is evacuated from the nucleus to reduce intradiscal pressure. Finally, a disc augmentation biomaterial is introduced into the nucleus. The disc augmentation biomaterial is introduced in such a manner that the disc augmentation biomaterial is maintained within the nucleus without having to repair an opening in the annulus surrounding the nucleus. | 05-06-2010 |
20100121311 | Skin Grafting Devices and Methods - The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site. | 05-13-2010 |
20100125265 | Cell Delivery System to Induce Cell Growth and Angiogenesis - Systems and methods that allow the local delivery of stem cells and/or endothelial progenitor cells to a treatment site. More particularly, this disclosure provides cell delivery systems used to induce cell growth and angiogenesis at a treatment site. | 05-20-2010 |
20100280493 | Methods and Systems for Treating Injured Cardiac Tissue - Methods and systems are disclosed for treating cardiac tissue by delivering a platelet composition which induces neovascularization in the cardiac tissue followed by a cell preparation which induces regeneration in the re-vascularized tissue. The platelet composition can additionally contain structural materials and/or bioactive agents. | 11-04-2010 |
20110137291 | USE OF RELAXIN TO INCREASE ARTERIAL COMPLIANCE - The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present invention further provides methods of increasing arterial compliance in individuals who have Type 1 or Type 2 diabetes. The present invention further provides methods of increasing arterial compliance in perimenopausal, menopausal, and post-menopausal women. The present invention further provides methods of increasing arterial compliance in individuals who have or who are at risk of developing age-associated arterial stiffness. | 06-09-2011 |
20110152840 | METHODS FOR REDUCING THE OCCURRENCE OF PRETERM DELIVERY AND OTHER PREGNANCY-RELATED CONDITIONS - The present invention relates to methods and kits for reducing the occurrence of preterm delivery and other pregnancy-related conditions in pregnant female subjects exhibiting one or more risk factors for preterm delivery and other pregnancy-related conditions. For example, the present invention relates to methods for reducing the occurrence of preterm delivery in a pregnant female subject having no history of preterm delivery and exhibiting one or more risk factors for preterm delivery (e.g., smoking during pregnancy). The methods and kits provide for the administration of a steroid hormone to the pregnant female subject. | 06-23-2011 |
20110166551 | SELECTIVE LYSING OF CELLS USING ULTRASOUND - Described are embodiments that employ ultrasonic energy to selectively lyse larger adipose cells in a suspension containing adipose cells of different sizes resulting in a suspension in which the only viable cells are the small adipose cells and stem cells. Embodiments provide for generating an acoustic standing wave field of sufficient intensity and proper geometry, that high shear stress is induced on the cell membranes of cells larger than a predetermined size. The remaining small adipose cells can be physically separated from the suspension after the suspension is subjected to the acoustic standing wave field. | 07-07-2011 |
20110190729 | METHODS OF INDUCING PLURIPOTENCY INVOLVING SOX2 PROTEIN - The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof. The invention also relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises removing from the mammal one or more responsive cells and culturing the cells in a suitable medium, introducing into the cells an effective amount of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof and subsequently returning the cells to the patient. In a further embodiment the invention relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises introducing into responsive cells of the mammal an effective amount of Sox2 protein or a functionally equivalent analogue, variant or fragment thereof. | 08-04-2011 |
20110190730 | METHODS OF INDUCING PLURIPOTENCY INVOLVING OCT4 PROTEIN - The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell of Oct4 protein or a functionally equivalent analogue, variant or fragment thereof. The invention also relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises removing from the mammal one or more responsive cells and culturing the cells in a suitable medium, introducing into the cells an effective amount of Oct4 protein or a functionally equivalent analogue, variant or fragment thereof and subsequently returning the cells to the patient. A further aspect of the invention relates to a method of treatment and/or prophylaxis of a degenerative disease or injury in a mammal, which comprises introducing into responsive cells of the patient an effective amount of Oct4 protein or a functionally equivalent analogue, variant or fragment thereof. | 08-04-2011 |
20110196343 | Methods for Expansion and Analysis of Cultured Hematopoietic Stem Cells - Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated glycoprotein (Mfap4). Methods for identifying hematopoietic stem cells are provided and isolated hematopoietic stem cells are also provided. | 08-11-2011 |
20110208162 | METHODS FOR PREVENTING AGGREGATION OF ADIPOSE STROMAL CELLS - The present invention relates to a methods, compositions, and admixtures which prevent the aggregation of a population of adipose stromal cells (ASCs), such as an isolated population of adipose stromal cells. In some embodiments, the present invention relates to admixtures and methods of use thereof comprising a population of ASC and a modulator of ASC aggregation. In some embodiments, a modulator of ASC aggregation includes, for example, ionic agents (e.g., heparin), chelating agents (e.g., EDTA), proteolytic agents.(e.g., trypsin or dispase), and agents which inhibit the expression of cell surface receptors and molecules on the surface of ASCs (e.g., inhibitors of integrins expression). In some embodiments, the methods to block ASC aggregation and the admixtures are useful in use of the ASCs to treat various diseases and/or conditions, and increases the safety and/or efficiency of ASCs. The methods, compositions and admixtures have utility in treating a number of conditions including, but not limited to, the treatment of any vascularized organs, such as heart, kidney, liver and the like. | 08-25-2011 |
20110213336 | METHOD OF AND APPARATUS FOR SAMPLING, PROCESSING AND COLLECTING TISSUE AND REINJECTING THE SAME INTO HUMAN PATIENTS - Methods of and apparatus for safely harvesting, processing (i.e. preparing), collecting and re-injecting adipose and other forms of tissue for immediate autologous tissue transplantation, explant culture endeavors or cell dissociations and the like. | 09-01-2011 |
20110213337 | Methods for the early diagnosis of ovarian cancer - The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment. | 09-01-2011 |
20110245804 | Methods and Compositions to Facilitate Repair of Avascular Tissue - Compositions and methods are provided for repairing damaged avascular zones, including intervertebral disc, in a patient in need thereof. | 10-06-2011 |
20110251593 | In Vivo and Ex Vivo Expansion of Hematopoietic Stem Cells With a Targeted Combination of Clinically Tested, FDA Approved Drugs - The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions. | 10-13-2011 |
20110301573 | HALOGENATED RHODAMINE DERIVATIVES AND APPLICATIONS THEREOF - Methods for treating a bacterial infection in a tissue sample are described. Tissue samples that are harvested from a patient may be infected with bacteria. A rhodamine compound is mixed with the infected tissue sample to form a mixture. The mixture is then exposed to radiant energy to inhibit or kill the bacteria. The exposed mixture is then transplanted into the patient. Examples of rhodamine compounds include 2′-(6-dimethylamino-3-dimethylimino-3H-xanthen-9-yl) 4′,5′-dichloro-benzoic acid methyl ester hydrochloride; 4,5-dibromorhodamine 110 2-(2-methoxy ethoxy)ethyl ester hydrobromide; acetate salt of 2,7-dibromorhodamine B hexyl ester; acetate salt of 2,7-dibromorhodamine B methyl ester; 4,5-dibromorhodamine 6G hydrobromide; rhodamine B 3-bromopropyl; acetate salt 2,7-dibromo-4′-carboxytetramethylrosamine methyl ester; 4-bromo-5-phenyl rhodamine B methyl ester chloride; 2,7-dibromo-4,5-dimethyl rhodamine B methyl ester bromide; 2-bromo-7-ethynyl rhodamine B methyl ester bromide; and 4,5-dibromo-2,7-di-n-butyl rhodamine B methyl ester bromide. | 12-08-2011 |
20110306948 | METHODS AND COMPOSITIONS RELATED TO TH-1 DENDRITIC CELLS - Certain embodiments of the invention are directed to methods for inducing an immunologic response to a tumor in a patient using mature dendritic cells transfected with a nucleic acid composition encoding one or more tumor antigens and loaded with a corresponding tumor antigen composition. | 12-15-2011 |
20110319868 | METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS - Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof. | 12-29-2011 |
20110319869 | HUMAN CYTOTOXIC T-LYMPHOCYTE EPITOPE AND ITS AGONIST EPITOPE FROM THE NON-VARIABLE NUMBER OF TANDEM REPEAT SEQUENCE OF MUC-1 - Novel MUC-1 epitopes outside the VNTR region are identified. In addition, the first agonist epitope of MUC-1 is described. The employment of agonist epitopes in peptide, protein and vector-based vaccine may well aid in the development of effective vaccines for a range of human cancers. | 12-29-2011 |
20110319870 | METHOD FOR INCREASING THE POOL OF NGN3+ ENDOCRINE PROGENITOR CELLS AND PANCREATIC ENDOCRINE CELL MASS - The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of β cells. The invention further concerns a method for treating diabetes. | 12-29-2011 |
20110319871 | INFECTIOUS DISEASE CELLULAR IMMUNOTHERAPY - Methods for treating infectious diseases in persons are provided. A person having an infectious disease may be vaccinated with a vaccine designed to induce an immune response against an infectious agent causing the infectious disease. Primed T-lymphocytes are removed from the person and the primed T-lymphocytes are stimulated to differentiate into effector T-lymphocytes in vitro. The effector T-lymphocytes are stimulated to proliferate, in vitro, and the effector T-lymphocytes are infused back into the person. | 12-29-2011 |
20120004642 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO - Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation. | 01-05-2012 |
20120004643 | Vaccines Based on Targeting Antigen to DCIR Expressed on Antigen-Presenting Cells - The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex. | 01-05-2012 |
20120010596 | Devices and Methods for Processing a Biomaterial in a Closed System - Disclosed herein are methods and devices for processing a biomaterial in a closed system and administering the processed biomaterial to a subject. | 01-12-2012 |
20120010597 | INDUCTION OF DENDRITIC CELL DEVELOPMENT WITH MACROPHAGE-COLONY STIMULATING FACTOR (M-CSF) - A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor is provided. M-CSF induces DCs to differentiate into subtypes, for example plasmacytoid DCs and conventional DCs. Induction with M-CSF can be achieved in vitro from hematopoietic precursors, such as bone marrow cells, or in vivo. In vitro, M-CSF-derived DCs can be used to produce cytokines and to stimulate other immune response cells. M-CSF can also be used to induce precursor cells removed from an animal to develop into DCs. In addition, these isolated DCs can be exposed to antigens to stimulate a specific immune response when reintroduced into the animal. Treatments for cancers, such as Acute Myeloid Leukemia, and autoimmune diseases such as Systemic Lupus Erythematosus, are also provided in the invention. | 01-12-2012 |
20120016340 | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER - Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer. | 01-19-2012 |
20120029472 | TNFR25 AGONISTS TO ENHANCE IMMUNE RESPONSES TO VACCINES - TNFR25 compositions enhance the immune response against antigens. Administration of TNFR25 agonists was found to enhance tumor rejection, responses against viral diseases and other infectious organisms. | 02-02-2012 |
20120029473 | USE OF 5C8 MAB AND DIRECT INDUCTION OF REGULATORY CD8+ T CELLS TO ESTABLISH PERMANENT AND SPECIFIC TRANSPLANTATION TOLERANCE - A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs. | 02-02-2012 |
20120041418 | BIOLOGIC TREATMENT SYSTEM AND METHOD - A delivery system is provided that is adapted to treat various urological pelvic disorders, such as prolapse, incontinence, and the like. The delivery system can include at least one biologic loaded or otherwise provided with a bioactive agent. The biologic can comprise any drugs, hormones or steroids, stem cells, growth factors, proteins, and/or other bioactive agents to promote cell or tissue growth for the treatment and strengthening of organ walls or tissue. The biologic is generally adapted to controllably release the agent to the surrounding tissue or organ to provide a local and targeted delivery. | 02-16-2012 |
20120046645 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 02-23-2012 |
20120059357 | COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MYOCARDIAL INJURY DUE TO A VASCULAR INSUFFICIENCY - The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury-due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. | 03-08-2012 |
20120059358 | DNA VACCINES ENCODING HEAT SHOCK PROTEINS - The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 60 (HSP60), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, and wherein the disease is other than insulin dependent diabetes mellitus (IDDM), thereby treating the disease. | 03-08-2012 |
20120065620 | BONE MARROW EXTRACELLULAR MATRIX EXTRACT AND THERAPEUTIC USE THEREOF - There is provided a method and use of hematopoietic stem cells for the treatment of various diseases. The differentiation of autologueous hematopoietic stem cells into myeloid lineages is used for reintroduction into a patient in addition to undifferentiated stem cells for the purpose of reconstituting both the defence and long-term engraftment. | 03-15-2012 |
20120071859 | INDUCIBLE INTERLEUKIN-12 - The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12, wherein the NFAT promoter is located 3′ of the nucleotide sequence encoding IL-12. Also provided are related recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. The invention further provides the use of the inventive nucleic acids or related materials in the treatment or prevention of cancer or an infectious disease in a mammal and in the induction of IL-12 expression in a mammal. | 03-22-2012 |
20120071860 | DENDRITIC CELL TUMOR INJECTION (DCTI) THERAPY - The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM) adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and LCM adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with radiation therapy or a chemotherapy regimen. | 03-22-2012 |
20120078229 | IN VIVO BIOREACTORS AND METHODS OF MAKING AND USING SAME - The present invention relates to an in vivo method of promoting the growth of autologous cartilage and bone tissue, including tissue that can be explanted to other locations in the subject. | 03-29-2012 |
20120095444 | POLYNUCLEOTIDES ENCODING A HUMAN TRIM-CYP FUSION POLYPEPTIDE, COMPOSITIONS THEREOF, AND METHODS OF USING SAME - A nucleic acid is provided which encodes a human TRIM-cyclophilin A fusion sequence encoding a human TRIM-CypA fusion protein which is active as an anti-viral agent, and in particular, as an anti-HIV-1 agent. Also provided is a nucleic acid encoding a polypeptide having both TRIM activity and cyclophilin activity. Also provided is an isolated polynucleotide encoding a human TRIM-CypA fusion protein, or variants thereof retaining the TRIM and cyclophilin A activities. Also provided are compositions thereof, antibodies that specifically bind thereto, and vectors and host cells comprising the nucleic acid or polypeptide. In addition, methods are provided for treating or preventing viral infection, or reducing viral load in a subject comprising administering the nucleic acid, polypeptide, vector, or composition to the subject in an amount effective to treat or prevent the viral infection. In some embodiments, the viral infection is HIV-I infection, hepatitis C infection, pox virus infection, vaccinia virus infection, or HTLV infection. | 04-19-2012 |
20120095445 | METHODS AND COMPOSITIONS FOR INCREASING TRICHOGENIC POTENCY OF DERMAL CELLS - Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay™. The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation. | 04-19-2012 |
20120101479 | [METHODS AND APPARATUSES FOR ISOLATING AND PREPARING STEM CELLS] - A method of preparing a population of stem cells for autologous implantation to a subject and apparatus used therein are provided. The cells are activated by irradiating the cells with one or more wavelengths of yellow and red and/or green light. In particular, the cells are irradiated with 575-595 nm (5-20 mW), and 630-635 nm or 660-670 nm (10-100 mW) and/or 510-540 nm (10-60 mW) of monochromatic light for 30-60 mins. Preferably the stem cells are adipose-derived stem cells. Therapeutic applications of the activated stem cells are also provided. | 04-26-2012 |
20120130350 | DETECTION AND TREATMENT OF AUTOIMMUNE DISORDERS - Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand. | 05-24-2012 |
20120136338 | IMMUNOLOGIC COMPOUNDS FOR PREVENTION, PROTECTION, PROPHYLAXIS OR TREATMENT OF IMMUNOLOGICAL DISORDERS, INFECTIONS AND CANCER - The present invention provides for methods of treating a cancer patient. In one methods, cancer cells are harvested from a patient. A therapeutic amount of a rhodamine derivative is then added to the harvested cancer cells. The harvested cells and the rhodamine derivative are then irradiated with a suitable wavelength and intensity for the selective killing of the cancer cells. The irradiated cancer cells are then mixed with antigen presenting cells to form a mixture. The mixture of cancer and antigen presenting cells are then injected into the patient. The present invention also provides for methods of inhibiting or treating an immunological disorder, infection, or a cancer in an individual. | 05-31-2012 |
20120150149 | PERCUTANEOUS ACCESS DEVICE SYSTEM FACILITATING CELL GROWTH THEREON - A process to facilitate growing of cells on a nanotextured percutaneous portal is provided that includes the placement of a nanotextured percutaneous portal partially within a subject. A vacuum manifold is secured to the nanotextured percutaneous portal. Upon coupling the vacuum manifold to a vacuum source, the growth of the cells is facilitated. | 06-14-2012 |
20120179139 | Delivery System for Cell-Based Therapies - A warm perfusion system that has the ability to support a tissue or organ at a near normal metabolic rate provides the mechanism not only for restored oxidative metabolism of the organ but for the delivery of cells, cell-based therapeutics, and growth and differentiation factors to a damaged tissue or organ. Subsequent to delivery of therapeutic cells, such as stem cells or progenitor cells, to the damaged organ, the cells can be prompted to grow, multiply and differentiate, thereby restoring damaged tissue. | 07-12-2012 |
20120184941 | MULTICOMPONENT MAGNETIC NANOPARTICLE DELIVERY SYSTEM FOR LOCAL DELIVERY TO HEART VALVE LEAFLETS AND OTHER ANIMAL TISSUES - The invention features devices, systems, and methods for targeted delivery of therapeutic agents in magnetic particle carriers to desired locations on tissue in the body. The systems and methods utilize at least one device comprising a source of magnetization, and at least one device comprising a magnetic or magnetizable material, to facilitate close tissue apposition and sealing, and to facilitate site-specific delivery of magnetic particles comprising therapeutic agents. | 07-19-2012 |
20120323222 | DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE - Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue. | 12-20-2012 |
20120323223 | APPLYING SHEAR STRESS FOR DISEASE TREATMENT - A system for applying shear stress ex-situ to a fluid. A method of preparing a fluid for intravenous administration to a patient. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient. | 12-20-2012 |
20120323224 | SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action. | 12-20-2012 |
20130012922 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER - Methods for inducing an immune response to a tumor in a subject are disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the CpG ODN is a K-type or a D-type CpG ODN. Methods for treating a tumor in a subject are also disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the tumor cells are autologous. In additional embodiments, the tumor is a lymphoma, cervical cancer, prostate cancer, breast cancer, colon cancer or a lung cancer. | 01-10-2013 |
20130041349 | SUBSTITUTE THERAPY FOR GLUCOCORTICOIDS - The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier. | 02-14-2013 |
20130072903 | Adipose Tissue Graft for Wound Healing - An improved method for preparing an adipose tissue biocomposite graft to serve a wide range of medical applications is presented. In particular, the embodiments consider a performing lipoplasty to derive a plurality of adipose tissue fragments containing at least one viable stem cell from a donor, harvesting said plurality of adipose tissue fragments from said donor, placing said plurality of adipose tissue fragments in contact with appropriate concentrations of a thrombin source and a fibrinogen source to achieve an appropriate gelling reaction and applying the mixture of said adipose tissue fragments, said thrombin source and said fibrinogen source to a wound site of the donor so as to promote wound healing. The adipose biocomposite graft of the present invention can be easily processed, molded and customized to precise dimensions. The present invention employs a three dimensional mold cavity to prepare multiple castings of said adipose tissue biocomposite grafts for an individual donor. | 03-21-2013 |
20130110084 | Devices and Methods for Processing a Biomaterial in a Closed System | 05-02-2013 |
20130116658 | APPARATUS FOR REMOVING CHEMOTHERAPY COMPOUNDS FROM BLOOD - A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject. | 05-09-2013 |
20130131639 | Methods of Preventing Platelet Alloimmunization and Alloimmune Platelet Refractoriness and Induction of Tolerance in Transfused Recipients - Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. Methods are provided to modify donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness. | 05-23-2013 |
20130131640 | METHOD OF CREATING AND SORTING FUSED CELLS - An efficient and simplified method for preparing and sorting fused cells is described herein. This approach yields fused cells useful in a variety of applications, including clinical treatment regimens, as cellular modulators of the immune system. | 05-23-2013 |
20130144266 | METHODS FOR REDUCING THE BLOOD PRIMING VOLUME AND MEMBRANE SURFACE AREA IN MICROFLUIDIC LUNG ASSIST DEVICES - A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices. | 06-06-2013 |
20130158515 | SYSTEM AND APPARATUS FOR CELL TREATMENT - The present invention relates to systems and apparatuses for improving quality and viability of biological material, such as harvested adipose cells, stem cells, or other cells or biological components, by treatment of the biological material with membrane-repairing/stabilizing agents or the like and/or mechanical removal of components, such as impurities and/or excess treatment agents. The present invention further relates to systems and apparatuses for transplanting tissue, such as adipose tissue. | 06-20-2013 |
20130178834 | Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases - Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with cold plasma and optionally with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment. | 07-11-2013 |
20130178835 | IDENTIFYING SYNTHETIC LIGANDS THAT BIND T-CELLS FROM PATIENTS HAVING AN AUTOIMMUNE DISEASE - The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. | 07-11-2013 |
20130184685 | METHOD FOR PREPARING RED BLOOD CELLS FOR INFUSION - The present invention relates to methods to prepare red blood cells (RBCs) for infusion to a patient. Depletion of RBCs with altered deformability is achieved by filtration through micro-bead filters. | 07-18-2013 |
20130190729 | DERIVATION OF HEMATOPOIETIC CELLS FROM ADULT MESENCHYMAL STEM CELLS - Methods and compositions for differentiating tissue resident multipotent mesenchmal stromal cells (MSCs) such as adipose tissue resident MSCs into a hematopoietic lineage are described. | 07-25-2013 |
20130197480 | METHODS AND SYSTEMS FOR DELIVERY OF LIVE CELLS - Described herein are methods for delivering live cells into tissue, such as skin or other animal tissue, that has been treated with a laser (e.g. at a minimally coagulating setting) to produce voids/channels/grooves in the tissue. It has been surprisingly discovered that voids having a minimal coagulation zone around the ablation void provide a receptive environment into which live cells are readily delivered (without the need for injections into the target tissue) and can therefore survive and persist. | 08-01-2013 |
20130226149 | APPARATUS AND METHOD FOR SEPARATING AND CONCENTRATING FLUIDS CONTAINING MULTIPLE COMPONENTS - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 08-29-2013 |
20130226150 | METHODS FOR SEPARATING CONSTITUENTS OF BIOLOGIC LIQUID MIXTURES - Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. | 08-29-2013 |
20130304032 | Bone fixation system with structure to enhance tissue growth and/or administer medicament inside bone - A bone fastener or an orthopedic implant that resides within the bone after orthopedic surgery has a threaded and/or unthreaded shaft, said shaft has a hollow portion and a solid portion. The hollow portion may have a structure that enhances tissue growth and may also hold materials that enhance tissue growth. The hollow portion may also hold materials to treat diseases and/or promote bone fracture healing. | 11-14-2013 |
20140005637 | Laser Nil Liposuction System and Method | 01-02-2014 |
20140066902 | DEVICE AND A SYSTEM FOR DELIVERY OF BIOLOGICAL MATERIAL - The present invention provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological material through a needle or a micro-needle or micro-needles or biodegradable micro-needles. | 03-06-2014 |
20140074068 | MULTI-COMPONENT METHOD FOR REGENERATIVE REPAIR OF WOUNDS IMPLEMENTING PHOTONIC WOUND DEBRIDEMENT AND STEM CELL DEPOSITION - A new and useful method for regenerative repair of wounds implementing photonic wound debridement and stem cell deposition is presented which consists of a Wound Assessment and Debridement, Wound Infrastructure Building, and Cell Deposition phases. The present invention allows structured regenerative repair of the wound, utilizes robotic systems to inspect, define and debride the wound, and prints an extracellular matrix on the prepared wound site which speeds healing using developing stem cell technologies. This device is believed to be useful in hospitals and clinics, wherein patients with wounds related to skin trauma such as burns, infection, or melanoma are present. An example of a theatre of use is a children's burn ward. This device is also believed to be useful in military hospitals which receive soldiers injured in combat. | 03-13-2014 |
20140088563 | METHOD OF DERIVING STEM CELLS, STEM CELLS, AND USE OF STEM CELLS FOR WOUND HEALING - A method of deriving isolated stem cells including: implanting a matrix in a wound site of a living organism; allowing cells to infiltrate the matrix; removing the matrix containing the infiltrated cells from the wound site; and removing the infiltrated cells from the matrix to provide isolated stem cells. Stem cells produced by this process, stem cells with certain characteristics, and methods for treating wounds using these stem cells are provided. | 03-27-2014 |
20140114285 | BONE MARROW ASPIRATION DEVICE - An embodiment of the invention is directed to a bone marrow aspiration device comprising a plurality of syringes, each of which operates in a series of sequential steps to obtain bone marrow of high quality and therapeutic value, i.e., having a high MSC/ml number. An embodiment of the invention preferably comprises three syringes, wherein a first syringe is used to aspirate bone marrow from a subject, a second syringe contains an anticoagulant, and the third syringe contains a mixture of the bone marrow aspirate and the anticoagulant. | 04-24-2014 |
20140128846 | USE OF PULMONARY SURFACTANTS IN LUNG TRANSPLANTATION AND METHODS THEREOF - The present invention concerns a method of treating an advanced lung disease in a patient in need thereof by lung transplantation. | 05-08-2014 |
20140171918 | USE OF A NOVEL SUBCUTANEOUS NEEDLE-FREE TECHNIQUE TO DELIVER TESTOSTERONE IN HYPOGONADAL MEN - Embodiments herein are directed to methods for increasing testosterone levels in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of testosterone by needle-free injection to an injection site. Some embodiments are further directed to a method of increasing testosterone levels in a subject in need thereof, by administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of testosterone and a pharmaceutically acceptable carrier by needle-free injection. Some embodiments are directed to a method of minimizing fluctuations in testosterone levels in a subject diagnosed with hypogonadism, comprising serially administering to the subject a therapeutically effective amount of testosterone by needle-free injection to an injection site. | 06-19-2014 |
20140221982 | SEMIPERMEABLE MEDICAL POUCHES AND THEIR USES - A novel process for bacterial production of nanocellulose hydrogel pouches for applications for cell therapy, cell encapsulation, cell delivery, cell proliferation and cell differentiation has been invented. The process is based on fermentation of bacteria producing nanocellulose in oxygen permeable mold interconnected with tubing with diameter less than 5 mm. The resulting Bacterial Nanocellulose (BNC) hydrogel pouch is biocompatible and non-degradable in the human body. The inner wall of the pouch is highly porous and supports cell migration, cell proliferation and cell differentiation. The wall of the pouch allows controlled diffusion of extracellular components. The BNC pouch with injected cells can be implanted and used for treatment of diseases such as diabetes by local delivery of insulin. There are numerous applications of BNC pouches with injected cells in tissue engineering, regenerative medicine and cancer treatment. | 08-07-2014 |
20140276640 | CONDUITS FOR ENHANCING TISSUE REGENERATION - Apparatuses, systems, and methods for enhancing bone or soft tissue regeneration are provided. For example, a conduit, having one or more segments, can originate at a tissue regeneration site and can have a first opening to promote physiological signals to enter the conduit and transit to a second opening that penetrates a histologically rich source of multipotent mesenchymal cells, promoting the multipotent mesenchymal cells to produce tissue regeneration response products, the response products transiting through the second opening to egress at the first opening of the conduit, and promoting tissue regeneration at the tissue regeneration site. Transit of the physiological signals and the tissue regeneration response products is promoted through physical and/or chemical means, as is promotion of the anatomical functionality of the regenerated tissue. For example, a number of the segments of the conduit can be formed at least partially from an osteoceramic material. | 09-18-2014 |
20140303598 | CELL CULTURE TRANSFERRING INSTRUMENT - A cell culture transferring instrument includes a cylindrical body held by an operator not shown in the drawing, a plunger inserted through the interior of the cylindrical body, a plurality of support members connected to a distal end of the plunger, and an adsorbent capable of adsorbing a sheet-shaped cell culture held by the support members. The support members in contact with the distal end of the cylindrical body are elastically deformed by displacing the plunger toward the proximal end side with respect to the cylindrical body in a state in which the sheet-shaped cell culture is adsorbed to the adsorbent, whereby the adsorbent and the sheet-shaped cell culture are deformed and housed in a housing hole in the cylindrical body. | 10-09-2014 |
20140309622 | INFUSION PUMP WITH TEMPERATURE MONITORING - This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid from a cartridge, a display a temperature sensor and a controller. The controller is configured to compare a temperature within the cartridge as measured by the temperature sensor to a threshold temperature and cause the display to display a message relating to temperature when the measured temperature goes beyond the threshold temperature. | 10-16-2014 |
20140330252 | BIOMATRIX STRUCTURAL CONTAINMENT AND FIXATION SYSTEMS AND METHODS OF USE THEREOF - The containment and fixation system of the present invention generally includes a biomatrix sleeve, biomatrix particles or combinations thereof made of a biomatrix material. The biomatrix material is comprised of one or more biocompatible proteins and one or more biocompatible solvents. The biomatrix material utilized in the sleeve and/or particles may also include one or more pharmacologically active agents like therapeutic biochemicals such as a bone mending biochemical (e.g. hydroxyapatite) or an angiogenic growth factor (e.g. BMP). | 11-06-2014 |
20140350527 | "Self-Regulating Device for Modulating Inflammation" - A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided. | 11-27-2014 |
20140371721 | SYSTEM AND METHOD FOR MIXING AND DISPENSING BIOMATERIALS - A system for mixing and dispensing at least first and second components of a biomaterial. The system includes a first syringe including a barrel having a proximal and distal ends. The barrel is configured to receive the first and second components of the biomaterial. There is a cap on the distal end of the barrel. The cap has an opening to allow materials to be directed into the barrel. The system further includes a mixing member. At least a portion of the mixing member is configured to enter the barrel through the cap. The mixing member is configured to move at least axially within the barrel to mix the first and second components. | 12-18-2014 |
20150032088 | SUSTAINED DRUG DELIVERY FROM SOLID STATE COMPOSITIONS WITH NANOCHANNEL MEMBRANES - Implantable devices and methods for delivering pharmaceutical substances into a patient. The implantable device includes the following components: (a) an implant body, (b) a reservoir in the implant body, (c) a heterogeneous composition disposed in the reservoir, which includes a pharmaceutical substance in the solid state contacted by a solution of the pharmaceutical substance, and (d) a nanochannel membrane for delivering the pharmaceutical substance from the reservoir to a patient. Extended, high-quality delivery of low solubility drugs such as hormones and chemotherapeutic agents are achieved. | 01-29-2015 |
20150073389 | DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS - Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease. | 03-12-2015 |
20150119858 | BONE DELIVERY SYSTEMS INCLUDING HOLDING AND FILLING DEVICES AND METHODS - A delivery system comprising a biodegradable single or multi compartment covering is provided. The covering can be a mesh bag including a pre-attached detachable holding member surrounding the opening of at least one compartment and a pre-attached removable filling member configured to fit within the opening of the at least one compartment. The opening of the bag can include a closing member. The pre-attached detachable holding member can be a collar including finger grips and is used to hold the bag in one position while filling it. In some embodiments, the pre-attached detachable filling member can be a funnel for loading the mesh bag with bone graft material. Once the covering is filled, the holding member and filling member can be removed and the covering is closed with a closing member such as a drawstring. A method of treatment utilizing the delivery system is also provided. | 04-30-2015 |
20150141964 | Surgical System And Method - In accordance with one aspect, an instrument is provided that permits the precise delivery of bone fusion material, such as autograft or allograft material, to one or more bones during surgical procedures. In another aspect, a system and a method are also provided for percutaneous delivery of bone fusion material, such as morselized autograft or bone graft, in a minimally invasive approach through one or more relatively small incisions in a patient. In yet another aspect, an expansion device is provided having an internal compartment and being shiftable between an insertion configuration and an expanded configuration. Bone fusion material may be injected into the internal compartment of the expansion device and travel therealong for bonding to one or more bones approximate the expansion device. | 05-21-2015 |
20150313623 | DERMAL MICRO-ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME - Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Other embodiments are described and claimed. | 11-05-2015 |
20150314081 | INJECTION SENSOR WITH FEEDBACK MECHANISM - The present disclosure provides devices for implanting tissue or other substances within the body. The devices can include a feedback mechanism, which can assist a surgeon in implanting the tissue or other substances by preventing excess shear force or pressure on the tissue or substance to be implanted. | 11-05-2015 |
20150351896 | TISSUE ARRAY PRINTING - Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects. | 12-10-2015 |
20160008044 | METHOD AND DEVICE FOR DELIVERING MEDICINE TO BONE | 01-14-2016 |
20160015890 | SYSTEM AND METHOD OF VARIABLE DOSE GLUCAGON DELIVERY - Disclosed are systems and methods for variable dose glucagon delivery without the need to manually reconstitute the glucagon. These systems and methods mat be utilized with or without a separate continuous glucose monitor. The variability of the dose may be determined manually by the user, caregiver or responder, or by preprogrammed algorithms utilizing the input from an external sensor such as a continuous glucose monitor. | 01-21-2016 |
20160030146 | VACCINE DELIVERY DEVICES - This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided. | 02-04-2016 |
20160031069 | CANNULATED ULTRA HIGH TORQUE DEVICE - A torque-limiting device may include a shaft extending axially through upper and lower shanks and a spring to connect to a nut. The upper and lower shanks may be under a force from the spring and further configured to selectively engage within a predetermined torque limit and disengage at above the predetermined torque limit. Accordingly, the shaft may receive torque up to the predetermined limit as provided by a user operating a handle of the torque-limiting device. The torque-limiting device may be disposable, reusable, economical, and have high torque capabilities. The shaft may include a lumen extending there through, and through which a variety of devices and materials may be delivered to a workpiece. | 02-04-2016 |
20160151541 | METHODS AND DEVICES FOR CELLULAR TRANSPLANTATION | 06-02-2016 |
20160160178 | IMMUNOTHERAPY USING STEM CELLS - Provided herein are cells, compositions and a method to produce in vitro programmed immune stimulating cells comprising: a) obtaining adipose cells from a subject; b) expanding said cells from step a) in culture so as to yield one or more populations of stem cells; c) differentiating said stem cells from step b) into hematopoetic stem cells, mesenchymal stem cells, connective cells, endothelial cells, cardio cells, osteo cells, muscle, cells and/or soft muscle tissue cells; and d) exposing said differentiated cells from step c) to 3D/4D printed molds of preselected bacterial, virus or particles thereof or exposing said differentiated cells from step c) to bacterial, virus or particles thereof so as to generate immune response triggering surface antigen expression in said differentiated cells from step c), thereby yielding in vitro programmed immune stimulating cells. | 06-09-2016 |