| Entries |
| Document | Title | Date |
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| 20080287913 | METHOD AND APPARATUS FOR CO-INJECTION - Systems and methods of co-injecting a solid object and an amount of fluid into a patient's tissue includes separably coupled syringe and needle portions. The syringe portion includes a barrel, a plunger, and a pushrod for disposing the solid object that is capable of independent movement with respect to the plunger. The needle portion includes a hollow needle configured to allow both the object and the fluid to pass out of the needle and into the patient's tissue. The needle portion may include a housing located behind the needle that is configured to hold the solid object. Once the needle portion and the syringe portion are coupled together, the device is operated in accordance with methods of the present invention to effectively co-inject the patient with the object and the amount of fluid. | 11-20-2008 |
| 20090012497 | SYSTEMS AND METHODS OF DELIVERING A DILATED SLURRY TO A PATIENT - A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate. | 01-08-2009 |
| 20090043282 | Drug Delivery Devices and Related Components, Systems and Methods - This description relates to drug delivery devices ( | 02-12-2009 |
| 20090093792 | EXTERNAL DRUG PUMP - Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described. | 04-09-2009 |
| 20090093793 | EXTERNAL DRUG PUMP - Apparatus is described for administering a substance to a subject. A vial contains the substance, an inner surface of the vial being shaped to define a protrusion therefrom. A stopper within the vial is slidably coupled to the vial. A first threaded element is (a) rotatable and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. The protrusion impedes rotation of the second threaded element with respect to the vial. The distal end of the second threaded element remains proximal to a distal end of the stopper during rotation of the first threaded element. The first threaded element, by rotating, linearly advances the stopper and the second threaded element toward a distal end of the vial. Other embodiments are also described. | 04-09-2009 |
| 20090143765 | Device for Mixing and Delivering Fluids for Tissue Repair - A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site. | 06-04-2009 |
| 20090143766 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. | 06-04-2009 |
| 20090198217 | Convenience IV kits and methods of use - Two convenience kits are disclosed. A first convenience kit provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. A second convenience kit which, being a companion to the first convenience kit, provides safety in access to a vial. Methods of use of both kits improve flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of connecting sites while reducing numbers of breaks required for associated medical procedures. | 08-06-2009 |
| 20090287184 | Autoflush Syringe Method - A two-chambered, sequentially injectable syringe is disclosed. The syringe has two concentric barrels, substantially cylindrical in shape. The outer barrel has an open end adapted for receiving an inner barrel/first piston. The inner barrel/first piston contains a flushing liquid. The syringe has a second piston slidably movable in the inner barrel and a latching mechanism that can alternate between a locked configuration and an unlocked configuration. In the locked configuration, the latching mechanism prevents the second piston from substantially all longitudinal movement relative to the inner barrel. In the unlocked configuration, the latching mechanism permits longitudinal motion of the second piston within the inner barrel. | 11-19-2009 |
| 20100063474 | MULTI-CHAMBERED MIXING SYRINGE DEVICE AND METHODS OF USE - The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided. | 03-11-2010 |
| 20100082013 | Diluent/Medication Mixing Syringe Assembly - A diluent/medication mixing syringe assembly is described which includes a cannula which extends through a syringe plunger assembly into a reservoir of the syringe assembly. The cannula facilitates injection of a diluent, medication or other fluid into the fluid reservoir of the syringe assembly immediately prior to use for mixing with a medication in the reservoir. In one embodiment, a mixing element is secured to a distal end of the cannula within the reservoir to improve mixing efficiency. | 04-01-2010 |
| 20100087799 | METHOD FOR ADMINISTERING A FLUID ACTIVE SUBSTANCE FROM A MULTI-CHAMBER AMPOULE - An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step. | 04-08-2010 |
| 20100106138 | METHOD AND APPARATUS FOR CONTAINING, TRANSPORTING, AND PROVIDING A MATERIAL - A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site. | 04-29-2010 |
| 20100106139 | Syringe-Carpule Assembly - A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient. | 04-29-2010 |
| 20100114067 | Multi-Chamber Mixing System - Mixing systems for storing and mixing multiple components of various medical compositions are provided. Generally, the instant mixing systems comprise a barrel, a plunger slidably disposed inside a barrel, and a pushing rod slidably disposed inside the plunger. The instant mixing system may further comprise multiple chambers for storing individual components or mixtures of components, with at least one chamber disposed in the barrel and at least one chamber disposed inside the plunger. | 05-06-2010 |
| 20100114068 | Autoflush Syringe Method - A two-chambered, sequentially injectable syringe is disclosed. The syringe has two concentric barrels, substantially cylindrical in shape. The outer barrel has an open end adapted for receiving an inner barrel/first piston. The inner barrel/first piston contains a flushing liquid. The syringe has a second piston slidably movable in the inner barrel and a latching mechanism that can alternate between a locked configuration and an unlocked configuration. In the locked configuration, the latching mechanism prevents the second piston from substantially all longitudinal movement relative to the inner barrel. In the unlocked configuration, the latching mechanism permits longitudinal motion of the second piston within the inner barrel. | 05-06-2010 |
| 20100121310 | MULTIPLE COMPONENT MIXING AND DELIVERY SYSTEM - A multiple component cartridge includes a barrel defining a chamber and a longitudinal axis. A first plunger is disposed within the chamber and in sealing engagement with the barrel. The first plunger includes at least one member and is movable relative to the barrel such that the at least one member is configured for movement relative to the first plunger to facilitate passage of at least a first component through the first plunger. A second plunger is disposed within the chamber and in sealing engagement with the barrel. The second plunger includes at least one member and is movable relative to the barrel such that the at least one member of the second plunger is configured for movement relative to the second plunger to facilitate passage of at least a second component through the second plunger. | 05-13-2010 |
| 20100130961 | SYRINGE AND METHOD FOR RECONSTITUTION OF DRY-FORM DRUGS AND MEDICINES - A method of reconstituting and administering an injectable fluid distributed to practitioners in dry-form includes receiving a drug or medicine in dry form, selecting a reconstitution concentration for the drug or medicine, reconstituting a desired number of units of the drug or medicine by adding diluent to the dry-form drug or medicine, selecting a syringe having units marked according to the selected reconstitution concentration, drawing up a desired number of drug or medicine units using the selected syringe, and administering a desired number of units according to the unit markings on the selected syringe. Such a syringe includes a barrel, a plunger assembly that has a plunger handle and a piston, a needle, and a needle cap. The syringe includes a visual indicia, representing a first drug concentration contained in the barrel, that is distinguishable from a corresponding visual indicia, on a second syringe, representing a second drug concentration. | 05-27-2010 |
| 20100204679 | MEDICAMENT MIXING AND INJECTION APPARATUS - A mixing and injection apparatus including a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber and a mixing chamber engagement portion including a second liquid conduit portion communicating with the first liquid conduit portion and configured for communication with a mixing chamber, the syringe attachment element and the needle base being configured to permit liquid communication between an interior of the syringe and the first liquid conduit portion when the syringe attachment element and the needle base are in the first relative engagement orientation and to permit liquid communication between an interior of the syringe and the needle when the syringe attachment element and the needle base are in the second relative engagement orientation, axially separated from the first relative orientation along the injection axis. | 08-12-2010 |
| 20100262125 | Disposable injector with a manually actuated piston and with a twin chamber system - The invention relates to a disposable injector with a housing, with a cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of this cylinder/piston unit, wherein the container adapter supports a container that is closed by an openable stopper. The piston of the cylinder/piston unit is movable via a pump rod. The container adapter engages at the front end around the cylinder of the piston/cylinder unit. The container adapter has an intermediate floor which supports a dual adapter having at least one through-channel. The container, which bears tightly with its stopper on the dual adapter, sits longitudinally displaceably in the rear of the container adapter. The container is opened by displacing it towards the intermediate floor and pushing the stopper into the container. | 10-14-2010 |
| 20100268193 | RECONSTITUTION MEANS FOR SAFETY DEVICE - The present disclosure describes a needle guard device or system that can be used with drugs requiring reconstitution. The needle guard is preferably a passive needle guard that can be used during reconstitution without activating the safety mechanism. Following administration of the medication, the needle guard shields a user from inadvertent needle sticks by extending a protective shield over the needle. | 10-21-2010 |
| 20100292672 | AUTOFLUSH SYRINGE - A syringe includes a cartridge and a second chamber. The cartridge includes a first chamber, a first end having a conduit in liquid communication with the first chamber, a liquid disposed within the first chamber, a second end moveable within the first chamber, and a locking mechanism. The conduit is adapted and configured to rely on a property of the liquid to prevent movement of the liquid out of the first chamber. The locking mechanism is adapted to prevent movement of the second end within the first chamber while in the locked configuration. The cartridge is moveable within the second chamber. | 11-18-2010 |
| 20100298811 | Steroid Delivery System - A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings. | 11-25-2010 |
| 20100305548 | APPARATUS AND METHODS FOR ADMINISTRATION OF RECONSTITUTED MEDICAMENT - A body portion of the apparatus comprises an interior cavity and a plurality of fluid lumens extending from the cavity to a periphery of the body portion. The apparatus further comprises a first fluid port in fluid communication with a first one of the fluid lumens. The first fluid port is configured to receive a syringe for injecting a liquid diluent and withdrawing a reconstituted liquid medicament. The apparatus further comprises a second fluid port in fluid communication with a second one of the fluid lumens. The second fluid port is configured to receive a medicament vial. The apparatus further comprises a third fluid port at an end of a third one of the fluid lumens for expelling the reconstituted liquid medicament. The apparatus further comprises a stopcock received within the body portion interior cavity and configured to regulate fluid communication between the fluid lumens. The stopcock has a first position in which fluid communication between the fluid lumens is blocked, a second position in which fluid communication is open between the first and second fluid lumens and a third position in which fluid communication is open between the first and third fluid lumens. | 12-02-2010 |
| 20100318062 | CONVEYOR APPARATUS AND METHOD FOR SUPPLYING A MEDICINE-SOLUTION MIXTURE - A conveyor apparatus and a method for supplying a medicine-solution mixture from a plurality of medicine-active ingredient solutions and additional solution constituents in a body by means of a plurality of feed devices is disclosed. The medicine-active ingredient solutions have different medicine-active ingredient parameters and constituents; the solution constituents have different parameters and constituents. The constituents of at least two medicine-active ingredient solutions and solution constituents are saved in at least one storage device; and are selected by means of one selection device for selection of at least one specific parameter and/or constituent of each medicine-active ingredient solution and/or the solution constituents. By means of a calculating device, at least one additional parameter from all selected parameters is calculated for the control and operation of at least one additional feed device for supplying at least one additional medicine-solution mixture to the body. | 12-16-2010 |
| 20100318063 | DUAL BARREL SYRINGE ASSEMBLY - A syringe system for dispensing or injecting one or more fluids is provided. The syringe system includes a hollow body that retains cartridge(s) and/or syringe(s) each containing a fluid, such as an injectable fluid e.g., a catalyst in one cartridge and a polymer in the other. Upon use for dispensing two fluids, the syringe system mixes the two fluids immediately prior to or concurrently with the dispensing or injecting of the fluids. The syringe system can also be configured to independently dispense a single fluid or immediately dispense multiple fluids sequentially. | 12-16-2010 |
| 20110106053 | TREATMENT APPARATUS - A treatment apparatus in the form of a bag which includes a first compartment containing at least one treatment substance, a second compartment containing at least one treatment substance, at least one openable seal between the first and second compartments, wherein at least one treatment substance in the first compartment is incompatible over time with at least one treatment substance in the second compartment. | 05-05-2011 |
| 20110106054 | MULTI-LUMEN MEDICAL MIXING DEVICE - Disclosed is a multi-lumen mixing device that includes a first and second lumen constructed and arranged to separately pass a first and second reagent to a mixing chamber in the device, where the mixing chamber includes a mixing feature that mixes the first and second reagents. The disclosed multi-lumen mixing device may also include a port in fluid communication with the reaction mixing to permit the product of the combined reagents to be injected into a patent. | 05-05-2011 |
| 20110160700 | DEVICE AND METHOD FOR AUTOMATICALLY PREPARING EMULSION DRUG - In preparation of an emulsion by causing a mixture to flow from one syringe through a connector into another syringe, an object is to prevent the air from being entrained into cylinders and prepare the emulsion containing no air bubble, and another object is to easily prepare a homogeneous emulsion. Provided is a syringe pressing apparatus, including: a syringe fixing mechanism for fixing two syringes to a casing, the two syringes being coupled to each other through a connector; a pressing mechanism for alternately pressing syringe plungers of the two syringes; and a plunger-pressure-measuring device for measuring a pressure with which the pressing mechanism presses the syringe plungers. | 06-30-2011 |
| 20110166549 | BI-DIRECTIONAL MOTION OF A LORENTZ-FORCE ACTUATED NEEDLE-FREE INJECTOR (NFI) - The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body. | 07-07-2011 |
| 20110166550 | MEDICAL DEVICES FOR DELIVERING FLUIDS DURING SURGERY AND METHODS FOR THEIR USE - Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion. There are also provided methods of use for the attached tip and pledget, including debridement, tissue translocation, delivery of fluid substances, absorption of fluid substances and combinations thereof. In a particular embodiment, the applicator places a thrombin solution into the attached pledget for delivery of an active hemostatic agent to a tissue site. | 07-07-2011 |
| 20110196342 | Disposable injector with dual-piston dual-chamber system - The invention relates to a method of making a solution for injection from a solvent and an active ingredient using a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered. | 08-11-2011 |
| 20110224648 | Syringe Filter Cap and Method of Using the Same for Administration of Medication Dosage - A syringe and filter cap ease the administration of medication to patients. The cap fits securely over the syringe nozzle and has at least one orifice. The orifice is configured to retain medication particles within the syringe, while allowing liquid to be drawn into the syringe through the cap. A kit combines the medication, the syringe and its plunger, the cap, and a liquid holder cup. The method of administering the medication entails: (a) removing the plunger from the syringe, (b) placing the cap over the nozzle, (c) inserting the particulate medication into the syringe, (d) re-inserting the plunger into the syringe, (e) drawing the desired amount of liquid into the syringe through the cap, thereby suspending the particulate medication within the liquid drawn into the syringe, (f) removing the cap from the syringe, and (g) delivering the medication dosage to the patient. | 09-15-2011 |
| 20110245803 | SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING - A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path. | 10-06-2011 |
| 20110276031 | SYSTEMS AND METHODS FOR PROVIDING A CLOSED VENTING HAZARDOUS DRUG IV SET - A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure. | 11-10-2011 |
| 20110282325 | DEHYDRATED PLASMA KIT - The present invention relates to a portable kit and methods for administering a therapeutic dose of autologous plasma to an injured person. | 11-17-2011 |
| 20110288531 | METHOD FOR STORING AND DELIVERING A DRUG - A method of storing and delivery a drug, such as by lyophilizing and reconstituting, comprises performing both storing and delivering with the same container closure assembly. The container closure is assembled in a preparation configuration during which lyophilization occurs. After lyophilizing, the powdered drug is forced into a spiral channel in the container closure assembly by a plunger. The plunger leaves substantially no head space for the powdered drug, and the assembly is sealed thereby now being in the storage configuration. For delivery of the stored powdered drug, a syringe of diluent is introduced to the container assembly thereby changing the assembly to the delivery configuration. The spiral channel is continuous between an input end and a delivery end with the delivery end being in fluid communication with a delivery outlet of the assembly. The assembly includes a diluent flow path that forces the diluent into a spiral channel at only the input end. As the diluent is forced to flow through the spiral channel from the input end to the delivery end, it reconstitutes the powdered drug, thereby reconstituting and delivering in the same step. No separate reconstituting and priming steps are needed. | 11-24-2011 |
| 20120029471 | TWO CHAMBER SYRINGE WITH LOCKING MECHANISM - A syringe includes a cartridge and a second chamber. The cartridge includes a first chamber, a second end, and a locking mechanism. The second end is movable within the first chamber between a first position and a second position. The locking mechanism has a locked configuration and an unlocked configuration and prevents movement of the second end within the first chamber while in the locked configuration. The locking mechanism includes: a flexible arm having a first end coupled to the second end of the cartridge and a second free end; a tab coupled to the second free end; and a groove in the inner surface of the chamber configured to receive the tab. The cartridge is moveable within the second chamber. | 02-02-2012 |
| 20120101478 | Dual Cartridge Mixer Syringe - A dual cartridge mixer syringe includes a first cartridge for containing a first formulation, a second cartridge for containing a second formulation, a first plunger for displacing said first formulation from said first cartridge, and a second plunger for displacing said second formulation from said second cartridge. A mixing assembly is provided for receiving and commingling the first and second formulation in unequal proportions; and a needle assembly, in fluid communication with said mixing assembly, provides for ejecting the commingled first and second formulation. | 04-26-2012 |
| 20120130349 | RECONSTITUTION MEANS FOR SAFETY DEVICE - The present disclosure describes a needle guard device or system that can be used with drugs requiring reconstitution. The needle guard is preferably a passive needle guard that can be used during reconstitution without activating the safety mechanism. Following administration of the medication, the needle guard shields a user from inadvertent needle sticks by extending a protective shield over the needle. | 05-24-2012 |
| 20120165787 | COMPOSITIONS AND METHODS FOR TREATING JOINTS - Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”) | 06-28-2012 |
| 20120191069 | System for Cooling and Pressurizing Fluid - A pump for delivering a fluid, created by cooling and pressurizing a fluid, into the intrathecal space of a patient, the pump comprising an input channel, an input reservoir in fluid communication with the input channel, a cooling apparatus configured to remove heat from the fluid and a pressurizing mechanism configured to impart pressure to the fluid, an output reservoir, and an output channel, and wherein the output channel is configured to be in fluid communication with a first lumen of a catheter and wherein the first lumen of the catheter is configured to be disposed within the intrathecal space of the patient. | 07-26-2012 |
| 20120203204 | Retro-Primed Medication Delivery System - A system and method for intravenous, intramuscular, or subcutaneous delivery of a reconstituted medication fluid with simultaneous, uninterrupted delivery of a primary fluid. A medication fluid is prepared by reconstituting a medication with a primary fluid as diluent. A container adapted to receive a medication is retro-primed with primary fluid from a primary bag. The primary fluid mixes with the medication to reconstitute the medication and form a medication fluid. A medication delivery system and method according to the present invention allows for the continuous infusion of primary fluid both during and after the administration of a reconstituted medication, using a closed system with reduced opportunities for contamination and infection. | 08-09-2012 |
| 20120245560 | MULTI-VESSEL COMPUTER CONTROL DRUG DELIVERY - Apparatus for combining and subcutaneously injecting a mixture of drug and other liquid such as a buffering solution, uses cartridges with cylinders containing the drug and other liquid, and pistons pushable toward discharge ends of the cylinders for discharging the liquids. A drive unit housing with motor therein is activated by computer to linearly move a motor plunger. A multiple cartridge holder receives cartridges with the drug and other liquid and has a mixing chamber with inlets connected to the discharge ends for receiving a mixture of drug and other liquids. Micro-tubing is connected to an outlet of the chamber and has a handpiece with subcutaneous injection needle at its opposite end for receiving and injecting the mixture. Plural cartridge plungers are engages via a motion transmission to the motor plunger and move into open ends of the cartridges to push the pistons and discharge liquids from the cartridges into the mixing chamber. | 09-27-2012 |
| 20120245561 | INTRAVENTRICULAR DRUG DELIVERY SYSTEM FOR IMPROVING OUTCOME AFTER A BRAIN INJURY AFFECTING CEREBRAL BLOOD FLOW - The described invention provides a flowable sustained release microparticulate composition, a kit for treating at least one cerebral artery in a subarachnoid space at risk of interruption due to a brain injury, a method of preparing the composition, and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury. | 09-27-2012 |
| 20120265171 | Pressure actuated valve for multi-chamber syringe applications - Methods and apparatus are disclosed for disposing a valve within a barrel of a conventional syringe to provide, first, a mixing syringe embodiment and, second, a sequential delivery syringe embodiment. Generally, the valve divides the syringe barrel into a proximal and a distal chamber. When used for mixing, the valve is self-displaceable by expansion of decompressing matter disposed within the valve against exterior matter permitting proximal displacement of the valve independent of character of matter in the distal chamber. For sequential delivery, switching of the valve occurs after switch opening causing pressure is relieved, thereby reducing inadvertent uncontrolled flow when the valve opens. In addition, a combination mixing and flush syringe is disclosed whereby a mixing and a flush capability is provided within a conventional syringe. | 10-18-2012 |
| 20120271279 | DISPOSABLE INJECTOR WITH A MANUALLY ACTUATED PISTON AND WITH A TWIN CHAMBER SYSTEM - A method for preparing a solution from a solvent and an active substance in and on a disposable injector with a housing, with an at least intermittently fillable cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of the cylinder/piston unit, wherein the container adapter supports a container which can be filled at least temporarily with active substance and which is closable by an openable stopper. | 10-25-2012 |
| 20120330279 | DEVICE FOR ADMINISTERING LIQUIDS INTO AN ANIMAL BODY, IN PARTICULAR FOR ADMINISTERING THERAPEUTIC AGENTS VIA ENDOVASCULAR INFUSION - A device for administering liquids to an animal, in particular therapeutic agents, comprises a vessel ( | 12-27-2012 |
| 20130012921 | SYSTEM AND METHODS FOR PREPARATION OF ADIPOSE-DERIVED STEM CELLS - A system for extracting and processing adipose tissue to generate a therapeutically effective amount of adipose-derived stem cells, comprising an adipose tissue extraction device and a modified centrifuge tube comprising a plurality of lipoaspirate inlet fittings, a plurality of processing fluid inlet fittings, and a plurality of pellet extraction tubes. The adipose tissue extraction device is used to extract a quantity of adipose tissue from a human being, the lipoaspirate is moved into the first modified centrifuge tube via a sterile transfer, a plurality of processing steps are performed to clean and dissociate the lipoaspirate, and a pellet containing an enhanced fraction of stem cells is obtained by centrifuging the modified centrifugal tube. The pellet is resuspended in a fluid and administered to a human patient for a therapeutic or cosmetic purpose. | 01-10-2013 |
| 20130131638 | Method and Apparatus for Controlled Reoxygenation - A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation. | 05-23-2013 |
| 20130218133 | DIFFERENTIAL PRESSURE BASED FLOW SENSOR ASSEMBLY FOR MEDICATION DELIVERY MONITORING AND METHOD OF USING THE SAME - A differential pressure based flow sensor assembly and method of using the same to determine the rate of fluid flow in a fluid system. The sensor assembly comprises a disposable portion, and a reusable portion. A flow restricting element is positioned along a fluid flow passage between an inlet and an outlet. The disposable portion further has an upstream fluid pressure membrane and a downstream fluid pressure membrane. The reusable portion has an upstream fluid pressure sensor and a downstream fluid pressure sensor. The upstream fluid pressure sensor senses the upstream fluid pressure at a location within the fluid flow passage between the inlet and the flow restricting element. The downstream fluid pressure sensor senses the downstream fluid pressure at a location within the fluid flow passage between the flow restricting element and the outlet. The process utilizes output of the sensors to calculate the flow rate of the fluid. | 08-22-2013 |
| 20130226148 | Mixing syringe - A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume. | 08-29-2013 |
| 20130274716 | Multiple Fluid Combining Syringe - A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end. | 10-17-2013 |
| 20140005636 | Multi-Compartment Pre-filled Mixing Syringes with Bypass | 01-02-2014 |
| 20140025040 | Method for Storing and Delivering a Drug - A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step. | 01-23-2014 |
| 20140031795 | DELIVERY SYSTEMS - A delivery system comprising a covering having at least two compartments is provided. A first compartment contains a first therapeutic agent and the second compartment can be unfilled and is configured to receive a second therapeutic agent. The first compartment and the second compartment are separated by at least one removable separation member, for example a drawstring, that can be pulled to allow the first and second therapeutic agents to mix prior to delivery at a selected surgical site. Either the first or second compartment of the covering define an opening further comprising a pre-attached sealing member, which can be a flap sealable by heat, sutures, pressing or interference fittings. The opening of the empty compartment can be configured to receive a filling member, such as a funnel fitted with a spring loaded clip for temporary attachment to the covering. A method of treating a bone defect in a patient utilizing the delivery system is also provided. | 01-30-2014 |
| 20140107620 | Nozzle For The Supply of Biological Material, In Particular Cells, Medical Device With Such A Nozzle, Use Of A Nozzle, Method For Mixing Fluids And Apparatus - A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber ( | 04-17-2014 |
| 20140107621 | Cell Spraying Device, Method and Sprayed Cell Suspension - The invention provides a device and methods suitable for producing a cellular spray of cells. The sprayed cells are of interest for covering and growing on a surface, including a skin wound. In applying the method and/or using the device, cells for grafting onto a patient are dispersed in a solution and sprayed with the device for distribution over the recipient's graft site. | 04-17-2014 |
| 20140121647 | SYSTEM FOR DISPENSING MULTIPLE FLUIDS AND A METHOD FOR USING THE SAME - A system for storing and dispensing first and second fluids. A syringe, including a first fluid chamber, a second fluid chamber, a first outlet communicating with the first fluid chamber and extending along a first axis; a second outlet communicating with the second fluid chamber and extending along a second axis, the second axis spaced from the first axis by a first distance. A container having first and second compartments separated by at least one wall and configured to store the first and second fluids, respectively, the first compartment having a first port positioned to be fluidicly connected with the first outlet and the second compartment having a second port positioned to be fluidicly connected with the second outlet. | 05-01-2014 |
| 20140148791 | SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING - A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path. | 05-29-2014 |
| 20140207113 | METHOD, ASSEMBLIES AND DEVICES FOR NUTRIENT DELIVERY - The invention concerns an assembly for delivering a flowable nutritional substance, e.g. made from homemade cooked foods or home prepared food or foods treated with a hand blender or equivalent, comprising a substantially tubular container | 07-24-2014 |
| 20140236121 | SYRINGE - A syringe ( | 08-21-2014 |
| 20140276637 | MULTI-CYCLE AND AUTO-DISABLE SYRINGE AND METHOD OF USE THEREOF - A syringe device that includes a stem, container, and a plunger, the plunger having tubes with a soluble substance that maintain a seal on compounds within the container's chamber, and/or a parabolic cover held in position by a soluble substance, thus allowing a multi-cycle usage to dispense medication to patients, even while preventing further use. | 09-18-2014 |
| 20150025505 | Bi-Directional Motion of a Lorentz-Force Actuated Needle-Free Injector (NFI) - The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body. | 01-22-2015 |
| 20150094689 | Dual Syringe Delivery Device and Method of Use - The present invention relates to a dual syringe delivery device consisting of three components which when collectively assembled result in the capability of accommodating varying syringe volume sizes. | 04-02-2015 |
| 20150126969 | DRUG DELIVERY DEVICE AND METHOD - A method for combining a first liquid component with a second lyo component in a drug mixing apparatus is provided. The method comprises displacing a seal that prevents the first liquid component within a first barrel from coming into contact with the second lyo/liquid component within a second barrel. The method also comprises using an activating mechanism to move the first liquid component from the first barrel through at least one communication channel to an area within the second barrel holding the second lyo component, allowing the first liquid component to mix with the second lyo component to form a medicament. Additionally the method comprises displacing a second seal that prevents a medicament from entering an outlet channel. The method also comprises using the activating mechanism to eject the mixed medicament from the drug mixing apparatus through the outlet channel. | 05-07-2015 |
| 20150290394 | PHARMACEUTICAL INJECTION DEVICE, METHOD FOR CONTROLLING PHARMACEUTICAL INJECTION DEVICE, PROGRAM, AND RECORDING MEDIUM - Certain embodiments of the present invention relate to a pharmaceutical injection device, and it is an object thereof to optimize the mixing of pharmaceutical in a pharmaceutical cartridge. To achieve this object, a pharmaceutical injection device may comprise a main case, a piston, a drive motor, a buzzer, and a controller. The main case has a cartridge holder. The piston is inserted into a pharmaceutical cartridge mounted to the cartridge holder. The drive motor drives the piston. The buzzer emits a sound that tells the user to shake the pharmaceutical cartridge to mix or dissolve its contents. Before activating the drive motor and injecting the pharmaceutical, the control unit controls the buzzer so that a sound is emitted at specific intervals to prompt shaking. | 10-15-2015 |
| 20150306367 | INSERT FOR LUER CONNECTION - An insert for a luer-type catheter connection includes a fluid pathway connecting a female end and a male end. The male end is configured for slidable insertion into a female luer fitting of a catheter, and the female end is configured to receive a male luer nozzle of a fluid delivery device. The insert also includes a threaded collar having internal threading faced for coupling with the female luer fitting and external threading faced for coupling with a locking collar on the fluid delivery device. A cartridge located in the fluid pathway is configured to hold a patency agent and further to release the patency agent into the catheter when fluid is passed through the cartridge. | 10-29-2015 |
| 20150343153 | DUAL CHAMBER MIXING SYRINGES AND METHODS OF USING SAME - Provided are mixing syringes having two chambers defined by a pair of pistons located one above the other inside the syringe. Mixing of components separately stored in each of the two chambers occurs when a reversible valve occluding a bore in the distal piston near the discharge end is unseated by removing the retention sleeve and pressing the knob, and the proximal piston nearer the top of the syringe is moved axially toward the distal piston. Further movement of the proximal piston causes it to abut the distal piston resulting in the two pistons acting as one to dispel the now mixed components through the discharge end. Methods are provided for using the syringes for storage and mixing components; discharging the components from the syringe such as by administering the components to a patient in need thereof through a needle when the components are a medicament product. | 12-03-2015 |
| 20150367072 | Portable Drug Mixing and Delivery Device and Associated Methods - A portable auto-injector configured to store a liquid component in a first chamber separately from a dry medication in a second chamber, wherein a first actuation mechanism opens a valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete. | 12-24-2015 |
| 20150374925 | Portable Drug Mixing and Delivery Device and Associated Methods - A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a sliding valve and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete. | 12-31-2015 |
| 20150374926 | EXTERNAL DRUG PUMP - Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described. | 12-31-2015 |
| 20160051752 | APPLICATOR, MIXING TIP AND METHOD FOR DISPENSING A MIXED FLUID - An applicator for dispensing a fluid for use during a medical procedure includes a dispensing body for containing the fluid. The dispensing body includes a conduit, and a mixing tip operatively connected to the conduit for receiving the fluid from the dispensing body. The mixing tip includes a tip body having an interior passage. The interior passage includes an inlet at a first end fluidly connected to the conduit for receiving the fluid from the conduit and an outlet in a distal wall at a second end opposite to the first end. An insert body is positioned within the interior passage. A first passage is positioned between the insert body and the tip body and fluidly couples the interior passage with the outlet in the distal wall. A mixing chamber is positioned between the insert body and the distal wall. The mixing chamber includes a static mixing element. | 02-25-2016 |
| 20160067423 | Minimally clogging device for delivery of fluids - An apparatus and method for delivery of fluids, particularly biological, reactive fluids. The apparatus provides an opening when force is acted on the apparatus, and closure when no force is acted thereon. The apparatus provides a cleaning mechanism to remove fluids and other materials from a mixing space after use. | 03-10-2016 |
| 20160074602 | Methods and Devices for Co-Delivery of Liquid and Powdered Hemostats and Sealants - The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices. | 03-17-2016 |
| 20160081706 | DEVICE FOR CHEMICALLY ASSISTED DISSECTION - A device and a method for delivering a solution to tissues and/or organs is described. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate in powder form. The method includes the steps of dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection. | 03-24-2016 |
| 20160095604 | Mixing Syringe - A perforated separator compartment or liquid permeable bag is attached to the input port in a regular syringe. The perforated compartment only allows liquids to exit the compartment into the main chamber of the syringe, restricting solid particles to the near proximity of the input port of the syringe. When the plunger of the syringe is pressed, the saline solution emerges from holes into the compartment, stirring up the settled particles. As the ejection continues, the compartment is compressed towards the input port by the plunger in order to eliminate any unused volume. | 04-07-2016 |
| 20160106928 | MULTI-STAGE MIXING SYRINGE - A system and method for mixing fluid constituents within a multi-stage mixing syringe, and delivering the mixture formed in the mixing syringe. The multi-stage mixing syringe system includes an outer syringe barrel defining a first contained volume therein, an intermediate syringe barrel and plunger configured for coupling within the outer syringe barrel and for advancement and retraction within the first contained volume, and defining a second contained volume therein, and an inner syringe plunger configured for coupling within the intermediate syringe barrel and plunger and for advancement and retraction within the second contained volume. | 04-21-2016 |
| 20160120527 | VACUUM EXPANDED DRY COMPOSITION AND SYRINGE FOR RETAINING SAME - The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum. | 05-05-2016 |
| 20160120528 | Hydrogel Pressure Sealant System - The present invention includes devices, systems, and methods for sealing a defect in body tissue. For example, the present invention includes a device for preventing leakage of air and other gases from the lung during and after lung biopsy. The device delivers a hydrogel composition which forms an air-tight sealant. In certain embodiments, the device simultaneously delivers one or more therapeutic agents, such as lidocaine, to the treatment area. | 05-05-2016 |
| 20170232196 | Portable Drug Mixing and Delivery Device and Associated Methods | 08-17-2017 |
