| Entries |
| Document | Title | Date |
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| 20080200898 | CATHETER GUIDANCE THROUGH A CALCIFIED AORTIC VALVE - A method of treating a patient with a calcified aortic valve includes introducing a guide wire into a blood vessel. The guide wire is advanced through the aorta to the aortic valve and then through the aortic valve. A balloon dilatation catheter is introduced into the blood vessel over the guide wire. The balloon dilatation catheter includes an elongate body, a distal portion, a guide wire lumen, an inflation lumen, and a dilatation balloon. The balloon dilatation catheter further includes at least one deflection wire lumen, the at least one deflection wire lumen having a distal opening proximal the distal portion, and at least one deflection wire residing in the at least one deflection wire lumen and having a distal end attached to the distal portion. The balloon dilatation catheter is advanced over the guide wire through the aorta. The deflection wire is pushed towards the distal portion so that the deflection wire bows outward. The balloon dilatation catheter is advanced through the aortic valve, and the dilatation balloon is inflated. | 08-21-2008 |
| 20080215033 | SPINAL DIAGNOSTIC METHODS AND APPARATUS - Methods, devices and systems facilitate diagnosis, and in some cases treatment, of back pain originating in intervertebral discs. Methods generally involve introducing one or more substances into one or more discs using a catheter device. In one embodiment, a patient assumes a position that causes back pain, and a substance such as an anesthetic or analgesic is introduced into the disc to determine whether the substance relieves the pain. Injections into multiple discs may optionally be performed, to help pinpoint a disc as a source of the patient's pain. In some embodiments, the catheter device is left in place, and possibly coupled with another implantable device, to provide treatment of one or more discs. A catheter device includes at least one anchoring member for maintaining a distal portion of the catheter within a disc. | 09-04-2008 |
| 20080215034 | Endotracheal cuff and technique for using the same - An inflatable balloon cuff with a water-swellable coating may be adapted to seal a patient's trachea when associated with an endotracheal tube. The water-swellable coating may enhance a cuff's mechanical pressure seal. The water-swellable coating may be loosely adhered or not adhered to the cuff in order to allow the coating to flow into and seal any leak paths that may form when the cuff is inflated in a patient's trachea. | 09-04-2008 |
| 20080221552 | AGENT DELIVERY PERFUSION CATHETER - An agent delivery catheter and method, configured to deliver an agent to an inner surface of a patient's body lumen by forming an agent containment pocket along the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 09-11-2008 |
| 20080221553 | System and method for rapidly cooling cardiac arrest patient - A combined occlusion/infusion catheter is placed in the aorta of a cardiac arrest patient to occlude the aorta at a location just above the renal arteries/celiac trunk while rapidly infusing a liter or more of cold saline into the aorta below the occlusion. This flushes white cells from the bowel (now placed into a state of hypothermic stasis) induces hypothermia in the whole body, with perfusion pressure of the cold fluid maximized to the brain. | 09-11-2008 |
| 20080243102 | Apparatus for segmental varicose sclerosis - The present invention relates to a minimally invasive apparatus and method of use to correct varicose veins by sclerosis. The apparatus comprising a semi-flexible first catheter having a proximal end, a distal end, and an outer surface. The first catheter also has a lumen area extending the length of the catheter and capable of receiving a guide wire. The proximal end is fitted to receive an inflation device and/or a closure device. At the distal end, a collapsible occlusive balloon is attached. Additionally, the apparatus has a second catheter having a proximal end, a distal end, an outer surface. The second catheter also has a lumen area extending the length of the second catheter. The second catheter has a larger lumen than the first catheter, allowing the first and second catheters coaxial alignment. The distal end of the second catheter adapted to from a sealing engagement with the periphery of the first catheter, allowing the second catheter to movably extend over and retract from the first catheter. Attached to the second catheter is a reservoir for dispensing a treatment agent into the lumen. The second catheter is adapted to connect to the reservoir. The treatment agent is dispensed to the vein via one or more side openings. | 10-02-2008 |
| 20080262470 | CATHETER HAVING A READILY BONDABLE MULTILAYER SOFT TIP - A balloon catheter having a soft distal tip member having a non-tacky inner (liner) layer material and a soft flexible outer layer material, with both materials being readily thermally bondable to the catheter balloon. | 10-23-2008 |
| 20080300573 | METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY - A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy. | 12-04-2008 |
| 20080319415 | Balloon Angioplasty Device with Distal Protection Capability - A balloon-angioplasty device for dilating a. region of a vessel of a patient which has been at least partially occluded by the presence of a stenotic lesion in the vessel is disclosed. The device comprises an elongate catheter shaft having an inflatable element located around the catheter shaft proximal to its distal end, the inflatable element comprising a dilatation balloon and a membrane which extends in a longitudinal direction around the dilatation balloon and has at least one flushing fluid opening located at or near its distal end. At least a portion of the flushing fluid that has entered the vessel through the or each flushing fluid opening (s) in the membrane is forced to flow in a retrograde direction between the treated stenotic lesion and the membrane. | 12-25-2008 |
| 20090005755 | GUIDE WIRE CONTROL CATHETER FOR CROSSING OCCLUSIONS AND RELATED METHODS OF USE - A wire control catheter for aligning and guiding a guide wire through a lesion in a vessel is provided. The wire control catheter includes a shaft having a guide wire lumen and a control wire lumen. A control wire passes through the control wire lumen and is used in combination with an articulation structure to deflect or curve a distal tip portion of the catheter. The distal catheter shaft may include a centering device for centering the catheter within the vessel. The distal catheter shaft may also include a pre-dilation balloon for dilating the lesion prior to performing angioplasty or other treatment on the lesion. A method of treatment of a blood vessel includes inserting a guide wire into the blood vessel and advancing a control wire over the guide wire until the distal tip of the catheter is near the occlusion in the blood vessel. The tip of the catheter then is deflected via a control wire and an articulation structure. The guide wire is then advanced across the occlusion. The control wire also may be advanced across the occlusion simultaneously with the guide wire or subsequent to the guide wire crossing. Prior to crossing the occlusion, the wire control catheter may be centered using a centering device. Subsequent to crossing the occlusion, the occlusion may be pre-dilated with a pre-dilation balloon of the wire control catheter. | 01-01-2009 |
| 20090024107 | Disc annulus closure - Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses. | 01-22-2009 |
| 20090069789 | METHODS AND DEVICES FOR LOCAL THERAPEUTIC AGENT DELIVERY TO HEART VALVES - Medical devices and methods for delivering a therapeutic agent to a heart valve. | 03-12-2009 |
| 20090088725 | ACCESSORY SLEEVE FOR A MEDICAL DEVICE - The present invention provides a medical system including a protective sleeve for a medical device having a distal end positionable in a blood vessel, the protective sleeve including a body defining a passage therethrough and a vent in fluid communication with the passage, where at least a portion of the distal end of the medical device is positionable within the passage. An introducer device may be included having a sheath, where the sheath defines a first passage for receiving a portion of the catheter. In addition, the sleeve may be releasably engageable with the introducer device for subsequent insertion of the medical device into the introducer device. | 04-02-2009 |
| 20090093791 | DEVICES AND METHODS FOR TREATING CHRONIC TOTAL OCCLUSION - Catheterization systems and methods for treatment of a condition within a blood vessel are provided that include the use of a catheter, a balloon immediately adjacent to the distal end of the catheter, an inflation device for expanding the balloon, and an occlusion-penetrating device for gaining access through an occlusion. The occlusion-penetrating device may include an indeflator configured to injected fluid at a high pressure, an RF wire, a hollow needle wire, a dissection tool, a laser wire, or even a very small balloon to exploit existing microchannels in the occlusion. | 04-09-2009 |
| 20090105686 | ADJUSTABLE-LENGTH DRUG DELIVERY BALLOON - A drug or agent coated balloon having a length which is adjustable in vivo is described herein. The balloon is configured to be coated or coatable with one or more drugs where the coating may be applied prior to advancement into a patient body or prior to balloon expansion within the patient body. The length of the expandable portion of the balloon is adjustable to approximate a length of the tissue region to be treated. Moreover, the drug-coated balloon may be used alone or it may be utilized to deploy luminal prostheses having one or more linked or otherwise coupled segments. | 04-23-2009 |
| 20090105687 | SCORING CATHETER WITH DRUG DELIVERY MEMBRANE - Angioplasty and other dilatation devices are provided with scoring elements. The device additionally incorporates a separate drug application membrane which is used to deliver drugs and other active substances to a body lumen, typically a blood vessel. The device functions to release drug into a region of the luminal wall as the scoring structure is radially expanded into the lumen wall. | 04-23-2009 |
| 20090112183 | MEDICAL DEVICES AND METHODS OF USE - A medical device for creating a fistula in a patient has a catheter including a first lumen and a second lumen for forming a fistula inside a body organ of a patient is disclosed. The second lumen may be capable of fluid communication with an internal bolster, wherein the internal bolster is attachable to the catheter near the distal end and is at least partially filled with a liquid. An external bolster may be adjustably attachable to the catheter outside the patient. Methods of use of medical devices according to the present invention are also disclosed. In one aspect of a method of use, at least a portion of the liquid within an internal bolster may be removed. Such a process may substantially collapse the internal bolster for removal of the medical device. | 04-30-2009 |
| 20090112184 | A DEVICE FOR DELIVERING MEDICAL TREATMENT - A medical device for the delivery of treatment fluid to body vessels is described. The device has a distal ( | 04-30-2009 |
| 20090118701 | METHODS AND APPARATUS FOR INSERTING MULTI-LUMEN SPLIT-TIP CATHETERS INTO A BLOOD VESSEL - Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel. | 05-07-2009 |
| 20090137981 | METHODS OF TREATING A BLOOD VESSEL - Described herein are methods for treating a blood vessel. In an embodiment, the method of treating a blood vessel comprises providing at least one manipulable tool in a blood vessel, depositing a non-solid polymerizable material into a deposition area of the vessel, wherein the polymerizable liquid hardens over time upon contact with blood in the blood vessel, and altering the shape of the polymerizable material while it hardens by manipulating the tool. | 05-28-2009 |
| 20090137982 | Guiding Catheter with Resiliently Compressible Occluder - A guiding catheter for providing proximal occlusion while intubating a branch vessel lumen in a patient. The catheter comprises an elongate hollow shaft having open proximal and distal ends and a resiliently compressible occluder fixed about the shaft adjacent the distal end, the occluder having a relaxed shape that tapers distally from a major diameter greater than a diameter of the vessel lumen. The occluder may comprise elastic foam material or an impermeable flexible cover clingingly enclosing a resilient support member. | 05-28-2009 |
| 20090157042 | METHODS, DEVICES AND COMPOSITIONS FOR CONTROLLED DRUG DELIVERY TO INJURED MYOCARDIUM - A method for modulating remodeling of an infarct region of a myocardium, the method including the controlled local delivery of therapeutic agent(s) employing microparticles as a carrier, and devices and compositions relating thereto. | 06-18-2009 |
| 20090157043 | LOW PROFILE AGENT DELIVERY PERFUSION CATHETER HAVING A FUNNEL SHAPED MEMBRANE - An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 06-18-2009 |
| 20090204104 | Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel - The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel. | 08-13-2009 |
| 20090254063 | Drug Coated Balloon Catheter - The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation. | 10-08-2009 |
| 20090254064 | WEEPING BALLOON CATHETER - Multiple-balloon catheters, and methods of treatment therewith, are provided including an inflatable inner balloon at least partially enclosed by an expandable outer balloon that has holes. The annular space between the inner balloon and the outer balloon is configured to promote delivery of the fluid evenly through holes in the outer balloon to avoid problems of underloading and/or overloading. Preferably, the annular space is in communication with the holes, and the annular space is configured to receive and then to release and distribute the fluid via the holes in a substantially uniform manner such that even amounts of fluid are released in the distal and proximal holes. The inner balloon may have various configurations including being tapered relative to the outer balloon. The outer balloon may also be tapered accordingly. The device may also include raised portions disposed in the annular space and configured to define channels having various configurations. | 10-08-2009 |
| 20090259210 | METHOD, APPARATUS AND KITS FOR FORMING STRUCTURAL MEMBERS WITHIN THE CARDIAC VENOUS SYSTEM - Material may be implanted or injected into cardiac veins as discrete masses for treating various cardiac conditions. A catheter suitable for delivering occluding agent into the cardiac venous system the heart includes a distal end that is positionable within a cardiac vein at a location where an occlusion is to be established. A barrier is provided for occluding the vein adjacent the barrier. A lumen (more than one lumen may be provided if desired) is disposed within the catheter tube and passes through the barrier to terminate at an aperture (more than one aperture may be provided if desired) distal of the barrier, for delivering the occluding agent into the vein beyond the barrier. An inner tube may be provided for introducing an occluder into the vein and spaced away from the barrier, for defining a vein segment between the barrier and the occluder. Methods and kits are also contemplated. | 10-15-2009 |
| 20090259211 | FLUID FEEDER, BALLOON CATHETER AND FLUID FEEDER SUPPORTING DEVICE - A fluid feeder ( | 10-15-2009 |
| 20090264859 | Catheter Having a Selectively Expandable Distal Tip - A catheter for use in a medical procedure includes an elongate outer member, an elongate inner member and an expandable distal tip attached to a distal most end of at least one of the outer member or inner member, wherein the distal tip has a first shape and a second shape and the tip can be easily transformed between the first and second shapes to aid in navigation through a patient's vascular system. A method of using the catheter includes inserting the catheter into the vascular system, navigating the distal end of the catheter through the vascular system, determining an obstruction within the vascular system, modifying the expandable tip from the first shape to the second shape in response to the determination of the obstruction, advancing the modified expandable tip passed the determined obstruction and returning the modified expandable tip to the first shape upon passing the determined obstruction. | 10-22-2009 |
| 20090275919 | Balloon Deployment Device and Method - Embodiments of the present invention provide systems and methods for deploying and/or retrieving a balloon configured to at least partially occlude a vessel, such as the coronary sinus. More particularly, embodiments of the present invention provide a stylet and a balloon catheter configured such that the stylet can be inserted into a lumen in the catheter and used to exert a force against an interior portion of the balloon in order to stretch the balloon and reduce the diameter of the balloon. In one embodiment, the stylet and the balloon both have specialty-configured tips that work together to prevent tearing of the balloon when the stylet is exerting a force against the interior of the balloon's tip. | 11-05-2009 |
| 20090275920 | SYSTEMS AND METHODS FOR TREATING A VESSEL USING FOCUSED FORCE - Systems and methods for treating a vessel include devices having a main elongated element with a balloon at its distal end, an auxiliary elongated element wherein a distal end of the auxiliary elongated element is proximal to the balloon, and a core wire having a internal core wire portion and an external core wire portion, wherein the external core wire portion is external to the balloon. In some embodiments, a distal connecting element is attached to the distal end of the balloon. In some embodiments, the distal connecting element is positioned at a rotational distance from the auxiliary elongated element. In some embodiments, the balloon is a fixed wire balloon. Inflation of the balloon causes guidewires positioned within the device and external core wires to be pushed up against the lesion, providing a focused force for cracking the lesion. | 11-05-2009 |
| 20090281521 | METHOD AND APPARATUS FOR RETAINING MEDICAL IMPLANTS WITHIN BODY VESSELS - The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems. | 11-12-2009 |
| 20090287182 | EXPANDABLE ILIAC SHEATH AND METHOD OF USE - Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, small cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the vascular system and has utility in the introduction and removal of implant delivery catheters. The access route is through the femoral arteries and the iliac arteries into the aorta. The distal end of the sheath is maintained in the first, low cross-sectional configuration during advancement to the arteries into the aorta. The distal end of the sheath is subsequently expanded using a radial dilatation device, which is removed prior to the introduction of implant delivery catheters. In an exemplary application, the sheath includes a supported proximal end, a supported distal end, and a collapsible center section. Certain configurations of the sheath are capable of being inserted in a first, small cross-sectional configuration, being expanded diametrically to a second, larger cross-sectional configuration, and then being reduced to a diametrically small size for removal. | 11-19-2009 |
| 20090287183 | EXPANDABLE TRANSAPICAL SHEATH AND METHOD OF USE - Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, small cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the vascular system and has utility in the introduction and removal of implant delivery catheters. The access route is through the ventricular myocardium, more specifically at the left ventricular apex, into the aortic root. The distal end of the sheath is maintained in the first, low cross-sectional configuration during advancement to the arteries into the aorta. The distal end of the sheath is subsequently expanded using a radial dilatation device, which is removed prior to the introduction of implant delivery catheters. In an exemplary application, the sheath includes a supported proximal end, a supported distal end, and a collapsible center section. Certain configurations of the sheath are capable of being inserted in a first, small cross-sectional configuration, being expanded diametrically to a second, larger cross-sectional configuration, and then being reduced to a diametrically small size for removal. | 11-19-2009 |
| 20090306625 | TREATMENT SYSTEMS AND METHODS FOR RENAL-RELATED DISEASES - Systems and methods are provided for locally delivering specific prophylactic, regenerative, or therapeutic agents within the body of a patient. Systems and methods can involve direct delivery of prophylactic, regenerative, or therapeutic agents into branch blood vessels or body lumens from a main vessel or lumen, respectively, and in particular into renal arteries extending from an aorta in a patient. Drug infusion techniques encompass specific treatment and prevention regimes for renal diseases including, but not limited to, Acute Kidney Injury, Renal Cell Carcinoma, Polycystic Kidney Disease, and Chronic Kidney Disease. | 12-10-2009 |
| 20100010470 | Nanotube-Reinforced Balloons For Delivering Therapeutic Agents Within Or Beyond The Wall of Blood Vessels, And Methods Of Making And Using Same - A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen. | 01-14-2010 |
| 20100016833 | Devices for the Treatment of Vascular Aneurysm - Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm. The elastin stabilization agent maybe embedded in a delivery composition. The device optionally has an aspiration means to improve the effectiveness of the treatment. | 01-21-2010 |
| 20100016834 | Device, system, and method for releasing substances in a body cavity - An implantable device for releasing one or more substances into a body cavity such as a urinary bladder, is provided. The device includes an inner balloon located within an outer balloon so as to define a lumen between the outer and inner balloons. The interior of the inner balloon is in fluid contact with an exterior surface of the device, for example via one or more conduits passing through the lumen between the two balloons. A first valve is used for filling the lumen; and a second valve is used for filling the inner balloon. The device is delivered to the body using a delivery catheter. The inner balloon is filled with the substance or substances to be released into the body cavity. The outer balloon is filled with a substance that is chosen to impart a desired specific gravity to the device. The substances to be released may be contained in particles coated with a soluble coating. The particles may be in suspension or embedded in a matrix. | 01-21-2010 |
| 20100069879 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating. | 03-18-2010 |
| 20100069880 | MEDICAL GUIDE ELEMENT WITH DIAMETER TRANSITION - Improved medical filaments for use with dilators to be inserted into a patient, for example into the vascular lumen, are provided, as well as combinations of filaments and dilators. Methods for use of such filaments and filament-dilator combinations are also described. The filament includes a proximal segment and a distal segment. The diameter of the distal segment is greater than the diameter of the proximal segment. The change in diameter is abrupt, providing a discrete step transition at a point along the filament which presents a proximally-facing surface on the distal segment. When the proximal segment of the filament is fully inserted into a dilator having a distal tip adapted for insertion into a patient, the dilator distal tip firmly abuts the proximally-facing end surface of the distal segment. The relative dimensions of the dilator tip and the discrete stepped transition of the filament provides full shielding or over shielding of the dilator tip, thereby facilitating passage of the dilator tip along the tissue track, through the puncture hole and into the orifice. | 03-18-2010 |
| 20100069881 | ASSIST DEVICE FOR SCLEROSING TREATMENT OF VARICOSE VEINS - An assist device ( | 03-18-2010 |
| 20100076401 | Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery - The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same. | 03-25-2010 |
| 20100076402 | Biasing a Catheter Balloon - A catheter can include a shaft; an inflatable balloon having a proximal end that is anchored to an end of the shaft; an elongate member that is separate from and disposed inside the shaft, extends into an interior chamber of the balloon, and is anchored to a distal end of the balloon; and a spring member that exerts a distally-oriented longitudinal force on the elongate member, relative to the shaft, where the distally-oriented longitudinal force causes the balloon to be biased in an extended position, away from the end of the shaft. The catheter can further include a sheath that surrounds the shaft and balloon before a treatment procedure. The balloon can be configured to be advanced outside the sheath during a treatment procedure and inflated, and the spring member can be configured to facilitate deflation and withdrawal of the balloon into the sheath following the procedure. | 03-25-2010 |
| 20100082012 | DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME - The invention, in one embodiment, is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window. | 04-01-2010 |
| 20100114065 | DRUG DELIVERY SHOCKWAVE BALLOON CATHETER SYSTEM - A catheter comprises an elongated carrier and a balloon carried by the carrier in sealed relation thereto. The balloon has an outer surface and is arranged to receive a fluid therein that inflates the balloon. The catheter further comprises a shock wave generator within the balloon that forms mechanical shock waves within the balloon, and a medicinal agent carried on the outer surface of the balloon. The medicinal agent is releasable from the balloon by the shock waves. | 05-06-2010 |
| 20100145307 | DUAL MODULUS BALLOON FOR INTERVENTIONAL PROCEDURES - A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. The elastomeric component is fixedly attached to the flexible but relatively non-distensible component and together they form a pressure vessel that can be inflated within the lumens of the body. | 06-10-2010 |
| 20100152702 | METHOD FOR DELIVERING MEDICATION INTO AN ARTERIAL WALL FOR PREVENTION OF RESTENOSIS - A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall. | 06-17-2010 |
| 20100168714 | THERAPEUTIC AGENT DELIVERY SYSTEM - This present disclosure relates to a medical device and method capable of locally administering therapeutic agents efficiently. The medical device preferably includes one balloon catheter with conduits external to the balloon and with ports in the conduits where the conduits provide adequate sealing and sufficient penetration of the body vessel wall. Moreover, the placement of the conduits and location of the ports help ensure the optimal and sufficient administration of the therapeutic agent evenly to the entire treatment site. Other embodiments of the present disclosure relate to providing means to isolate the inflation medium and the therapeutic agent during administration to the treatment site and to introduce more than one therapeutic agent simultaneously to the treatment site. | 07-01-2010 |
| 20100179510 | APPARATUS FOR FORMING AN ANASTOMOSIS - A surgical instrument, for forming an anastomosis between first and second lumens in a patient, includes a first catheter, a second catheter, a hollow needle, a guide wire, an inflatable member, and a hollow sleeve. The first catheter includes at least one first opening, which may be configured to slidably receive the hollow needle and the guide wire, which may be disposed within the hollow portion of the needle, and at least one second opening. The hollow needle includes a rotary needle. The inflatable member is mounted near the distal end of the first catheter and is in fluid communication with the second opening. The magnet is polarized such that magnetic attraction occurs perpendicular to an axis of the cylindrical body. The hollow sleeve is configured to retain at least a portion of the inflatable member, the guide wire, the hollow needle, and the magnet. | 07-15-2010 |
| 20100191220 | METHOD AND APPARATUS FOR CONTROLLED VESSEL OCCLUSION - A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume. | 07-29-2010 |
| 20100191221 | Rotatable Catheter Assembly - A catheter assembly comprises a catheter shaft, a balloon and a pair of collars. The collars may be fixed or rotatable about a catheter shaft prior to exposure to an electric current. Where the collars are fixed to the shaft, the balloon is rotatable about the collars. When exposed to the electric current the collars expand to engage the waists of the balloon thereby sealing the balloon. Where the collars are rotatable about the shaft, the each waist of the balloon is engaged to a respective collars. When the rotatable collars are exposed to the electric current the collars expand to engage the shaft of the catheter thereby sealing the balloon. | 07-29-2010 |
| 20100198190 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which is complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue. | 08-05-2010 |
| 20100228228 | MEDICAL DEVICE FOR DISPERSING MEDICAMENTS - For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue. | 09-09-2010 |
| 20100249749 | Drug Delivery Catheter With Soluble Balloon Coating Containing Releasable Microspheres and Delivery Method - A drug delivery catheter and method for delivering microcapsules or microspheres containing a drug, pharmacological or other bioactive agent includes a balloon catheter having a coating on the balloon of a soluble biocompatible polymer containing a plurality of microcapsules or microspheres containing a drug or other agent. The balloon is porous to allow it to be inflated with a solvent fluid that passes through the porous wall of the balloon and dissolves the polymer, releasing the microspheres. | 09-30-2010 |
| 20100262124 | SPIRAL BALLOON CATHETER - The present invention provides a balloon catheter system comprising one or more conduits to which are attached a compliant balloon having a non-helical shape in its deflated state, wherein said balloon is constructed such that is capable of adopting a spiral or helical conformation upon inflation. In addition, the present invention also provides methods for using said balloon catheter system. | 10-14-2010 |
| 20100268191 | Drug Delivery Catheter using Frangible Microcapsules and Delivery Method - A drug delivery catheter and method are provided for delivering drugs to a targeted region of a lumen include drug-laden microcapsules provided within a porous catheter balloon with an effective pore size that prevents free-flow of the microcapsules through the porous wall of the balloon. The microcapsules are frangible under the influence of increased pressure within the balloon. In an alternative embodiment, the microcapsules may be mechanically ruptured by compression between the outer porous balloon and optional, inner, non-porous balloon. The drug is emitted from the microcapsules through the balloon pores and against the targeted luminal surface. | 10-21-2010 |
| 20100331816 | RAPAMYCIN COATED EXPANDABLE DEVICES - Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients. | 12-30-2010 |
| 20100331817 | THERAPEUTIC AGENT DELIVERY DEVICE WITH A DUAL BALLOON HAVING DISTAL TAPER APERTURES - The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed. | 12-30-2010 |
| 20110022027 | DRUG-ELUTING CATHETER AND METHOD OF MANUFACTURING THE SAME - Biocompatible nanoparticles | 01-27-2011 |
| 20110054443 | BALLOON CATHETER DEVICES WITH DRUG DELIVERY EXTENSIONS - A medical device is provided for dilatation of a vessel and delivery of therapeutic agent to a wall of the vessel. The medical device comprises a catheter, a balloon located at a distal end of the catheter, and a drug delivery extension. The drug delivery extension is configured to extend beyond the outer surface of the balloon when the balloon is in its expanded configuration in order to deliver the therapeutic agent to an area beyond the outer surface of the balloon. The drug delivery extension may be one or more tubes, elongate members and/or expandable structures. The drug delivery extension may include a sheath for drug delivery. | 03-03-2011 |
| 20110054444 | Myocardial Injector with Spring Loaded Protective Array - A system is provided for performing injections in the ventricle of a patient. The system includes an injection catheter with a proximal and distal end. Importantly, a flexible array is mounted at the distal end of the injection catheter and is moveable between a protective configuration and a flared configuration. Also, a needle of variable length is mounted on the distal end of the injection catheter and is covered by the flexible array when the array is in its protective configuration. In order to manipulate the flexible array, a locking mechanism is mounted on the proximal end of the injection catheter for engagement with the flexible array. When selectively operated, the locking mechanism moves the array from its protective configuration to the flared configuration, holds the array in its flared configuration for an injection, and subsequently moves the array back to its protective configuration. | 03-03-2011 |
| 20110071497 | BALLOON FIXATED CATHETER - A balloon catheter for the delivery of a medication comprises a balloon fixation portion and a medication infusion portion. The balloon fixation portion comprises an expandable balloon at the distal end of a tube, the balloon inflatable to a size sufficient to retain the catheter within the area of placement, and a check valve at the proximal end of the balloon fixation portion for inflation or deflation of the balloon. The medication infusion portion comprises a tube with a precise diameter lumen functioning to control the flow rate therethrough, the tubing having one or more holes along its distal portion for infusion of medication into the patient and means on its proximal end for attachment to an infusion pump. The balloon fixation portion and the medication infusion portion are independently produced and then joined along a distal portion of both to provide a unitary catheter for placement into the body. | 03-24-2011 |
| 20110071498 | FREE-STANDING BIODEGRADABLE PATCH - Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents. | 03-24-2011 |
| 20110071499 | FREE-STANDING BIODEGRADABLE PATCH - Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents. | 03-24-2011 |
| 20110087191 | BALLOON CATHETER WITH SHAPE MEMORY SHEATH FOR DELIVERY OF THERAPEUTIC AGENT - A medical device is provided comprising a catheter, a balloon mounted on the catheter, and a sheath comprising a shape memory material, the sheath being located around the balloon. The sheath has a protective condition in which the sheath forms a plurality of pockets in a generally closed position and an activated condition in which the pockets are in a generally open position. A therapeutic agent is located within the generally closed pockets of the sheath when the sheath is in the protective condition. The therapeutic agent is exposed for delivery to a target site when the sheath is transitioned from the protective condition to the activated condition. | 04-14-2011 |
| 20110106051 | Multi-lumen heat transfer catheter systems - Heat transfer catheter apparatus and methods of making and using same are disclosed wherein fluid connection means is provided between the distal portions of two adjacent, thin-walled, high strength fluid lumens to define a closed loop fluid circulation system capable of controlled delivery of thermal energy to or withdrawal of thermal energy from remote internal body locations. | 05-05-2011 |
| 20110112510 | METHODS, COMPOSITIONS AND APPARATUS FOR DELIVERING HETEROLOGOUS MOLECULES TO CELLS - A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex. | 05-12-2011 |
| 20110118703 | EXPANDABLE FLUOROPOLYMER DEVICE FOR DELIVERY OF THERAPEUTIC AGENTS AND METHOD OF MAKING - A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. | 05-19-2011 |
| 20110125132 | APPARATUS AND METHODS FOR TREATING OBSTRUCTIONS WITHIN BODY LUMENS - An apparatus is provided that is operable in different modes to perform various functions for treating a body lumen. The apparatus includes a shaft including proximal and distal ends, a lumen extending therebetween, and a balloon on the distal end. The apparatus includes a valve on the distal end that selectively opens or closes an outlet communicating with the lumen. With the valve open, fluid introduced into the lumen exits the outlet into a body lumen. With the valve closed, fluid introduced into the lumen expands the balloon. The valve may be biased to be closed, e.g., by a spring element disposed within the balloon. Optionally, the apparatus also includes an actuator for expanding a helical member within the balloon interior, e.g., either before or after expanding the balloon, such that the helical member and balloon may adopt an expanded helical shape for removing material within a body lumen. | 05-26-2011 |
| 20110160698 | Balloon Catheter for Treating Stenosis of Body Passages and for Preventing Threatening Restenosis - The present invention is directed to a method for coating catheter balloons with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon. | 06-30-2011 |
| 20110166547 | Balloon Catheter Systems for Delivery of Dry Drug Delivery Vesicles to a Vessel in the Body - Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon. | 07-07-2011 |
| 20110166548 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES - The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers. | 07-07-2011 |
| 20110178503 | BALLOON CATHETERS WITH THERAPEUTIC AGENT IN BALLOON FOLDS AND METHODS OF MAKING THE SAME - Catheter devices for delivering therapeutic agent and methods of making the same. A method comprises applying, when the balloon is unexpanded and folded, a first coating to a first surface area of the balloon that is substantially exposed when the balloon is unexpanded and folded, the first coating being a coating to which the therapeutic agent coating material is substantially non-adherent; applying a therapeutic agent coating material to the balloon such that the therapeutic agent coating material adheres to a second surface area not coated with the first coating. Upon completion of the coating method, the therapeutic agent coating is substantially disposed within one or more folds of the balloon. A catheter device comprises therapeutic agent coating that is substantially covered when the balloon is unexpanded and folded. Expanding the balloon opens the one or more folds and substantially exposes the therapeutic agent. | 07-21-2011 |
| 20110184384 | Blood Vessel Permeability-Enhancement For The Treatment Of Vascular Diseases - This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents. | 07-28-2011 |
| 20110190727 | INTERVASCULAR CATHETER, SYSTEM AND METHOD - The present disclosure relates to medical devices and methods, for use in a vascular system. The apparatus includes a balloon catheter having an elongate body, balloon, and fluid control valve for ischemic post-conditioning therapy and/or reperfusion. | 08-04-2011 |
| 20110196340 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 08-11-2011 |
| 20110245802 | OCCLUSION CATHETER HAVING COMPLIANT BALLOON FOR USE WITH COMPLEX VASCULATURE - A catheter used for treatment of complex vasculature, such as a bifurcated aneurysm, is provided with an inflatable balloon at a distal portion thereof. The shape, location and material of the inflatable balloon are selected such that when inflated, the balloon conforms to the shape of the complex vasculature, or at least a portion thereof, without appreciably deforming the vessel walls. In this manner, the balloon can be used to control flow in the vasculature, for example occluding a selected branch of the vasculature during introduction of material in order concentrate the material and minimize its disbursement by blood flow. | 10-06-2011 |
| 20110251590 | BALLOON CATHETERS WITH FIBERS FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer. | 10-13-2011 |
| 20110270224 | CATHETER SYSTEM PROVIDING STEP REDUCTION FOR POSTCONDITIONING - A pre-assembled kit for administering ischemic postconditioning comprising a catheter and a handle having a fluid circuit to control and modulate flow of inflation fluid to and from a balloon wherein the catheter is free from additional assembly and preparation procedures such that it is ready-to-use within a variety of vessel sizes. | 11-03-2011 |
| 20110270225 | METHOD FOR INCREASED UPTAKE OF BENEFICIAL AGENT AND EJECTION FRACTION BY POSTCONDITIONING PROCEDURES - A method for improving tissue uptake of beneficial agent and ejection fraction. | 11-03-2011 |
| 20110270226 | BALLOON CATHETER DEVICES WITH SHEATH COVERING - Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. In one aspect, one or more sheaths are disposed around the balloon with the therapeutic agent being disposed within the sheath, being disposed over the sheath, being contained in the space between the sheath and the balloon, or being otherwise associated with the sheath. In another aspect, the balloon includes a micro-electromechanical system (MEMS) for drug delivery. | 11-03-2011 |
| 20110301571 | Reperfusion Catheter System - A reperfusion catheter system with an introducer sheath having an inner wall defining a longitudinal opening extending from a proximal portion to a distal end. A balloon catheter has an outer wall and has a longitudinal opening extending from a proximal portion to a distal end. The balloon catheter is disposed through the opening in the introducer sheath, and the balloon catheter has an inflatable balloon at the distal end. A conduit has a first end disposed in fluid communication with the area inside the introducer sheath between the inner wall of the introducer sheath and the outer wall of the balloon catheter. The conduit also has a second end disposed in fluid communication with the inside of the balloon catheter. The invention provides for the establishment of artificial antegrade blood flow in the lumen of a target vessel through a path between the outer wall of the balloon catheter and the inner wall of the introducer sheath, through the conduit, through the opening in the balloon catheter, and exiting through the distal end of the balloon catheter. When the occlusion balloon is inflated, there is no back flow in the target vessel and, as the artificial antegrade flow takes place, there is full control of the target vessel blood flow and as a result a significant increase in the safety of the embolization procedures. | 12-08-2011 |
| 20110313400 | WEEPING BALLOON CATHETER - Balloon catheters, and methods of treatment therewith, are provided including an inflatable first balloon at least partially enclosed by an expandable second balloon that has holes. The annular space between the first balloon and the second balloon is configured to promote delivery of the fluid evenly through holes in the second balloon to avoid problems of underloading and/or overloading. Preferably, the annular space is in communication with the holes, and the annular space is configured to receive and then to release and distribute the fluid via the holes in a substantially uniform manner such that even amounts of fluid are released in the distal and proximal holes. The first balloon may have various configurations including being tapered relative to the second balloon. The second balloon may also be tapered accordingly. The device may also include raised portions disposed in the annular space and configured to define channels having various configurations. | 12-22-2011 |
| 20110319866 | METHODS AND DEVICE FOR SYNERGISTIC MITIGATION OF REPERFUSION INJURY AFTER AN ISCHEMIC EVENT - A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject. | 12-29-2011 |
| 20120035588 | DEVICES AND METHODS FOR LOW SHEARING LOCAL DELIVERY OF THERAPEUTIC AGENTS TO THE WALL OF A BODILY LUMEN - The invention relates generally to devices and methods for local delivery of therapeutic agents to the wall of a bodily lumen with minimal shearing damage to the therapeutic agents, more specifically to the wall of a blood vessel following atherectomy. A preferred delivery mechanism comprises a balloon, or double balloon, though any distal catheter design may be used to reduce shear stress and to conserve and/or isolate the therapeutic substance. | 02-09-2012 |
| 20120059356 | DEVICE AND METHOD FOR REMOVING MATERIAL FROM A HOLLOW ANATOMICAL STRUCTURE - A medical device for removing a material from a hollow anatomical structure is provided. The device includes a radially expandable capture member. The device includes a treatment segment that is positioned distally of the capture member in use and having at least one exit port adapted for delivering a fluid agent to the material. The device includes an embolic capture device that is positioned distally of the treatment segment in use and including a radially expandable filter for capturing a part of the material which travels downstream of the treatment segment. Additionally, a method is provided herein for infusing, injecting, distributing, or releasing an intended fluid into a hollow anatomical structure. | 03-08-2012 |
| 20120071854 | ENDOVASCULAR DEVICES AND METHODS - Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion, inserting the device into the vascular lumen, positioning the distal portion in the vascular wall to at least partially surround the occlusion, and removing at least a portion of the surrounded occlusion from the lumen. | 03-22-2012 |
| 20120071855 | COMPOSITIONS AND METHODS OF VASCULAR INJURY REPAIR - The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of CD34+/CXCR-4+ cells having CXCR-4-mediated chemotactic activity, methods of preparing these compositions and use of these compositions to treat or repair vascular injury, including infarcted myocardium. | 03-22-2012 |
| 20120078227 | Drug Coated Balloon Composition with High Drug Transfer to Vessel - Drug delivery balloons are configured with a carrier film of biodegradable polymer. The carrier film includes a drug or has a drug carried thereon. The balloons utilize a film layering system that is designed to separate the carrier film substantially intact from the balloon when expanded, so that the carrier film and the drug are left in place at the tissue site. | 03-29-2012 |
| 20120078228 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which is complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue. | 03-29-2012 |
| 20120101476 | Transvenous Soaker Catheter Using Microfibers - A catheter tip for an infusion catheter has a hollow tubular shaped base member with a pair of annular shaped inflation balloons positioned in parallel on the base member. A plurality of microfibers are mounted on the cylindrical surface section between the balloons. The microfibers are in fluid communication with the lumen of the catheter tip. In operation, the catheter tip is advanced into the vasculature of a patient and to a site in a small vein that is near the target tissue for infusion. The balloons are then inflated to anchor the catheter tip, and fluid medicament is infused through the microfibers. In an alternate embodiment, the microfibers can be replaced with at least one orifice. | 04-26-2012 |
| 20120109105 | THERAPEUTIC AGENT DELIVERY SYSTEM AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC SUBSTANCES TO A BIOLOGICAL LUMEN - The invention provides a system and method for localized application of therapeutic substances within a biological lumen and to the wall of the lumen. In various embodiments, a biodegradable tubular prosthesis comprising a plurality of pores is deployed within a biological lumen. Subsequent to, or in conjunction with, the deployment of the prosthesis, a drug-eluting balloon comprising at least one therapeutic agent is expanded within the lumen of the tubular prosthesis, thereby releasing the agent(s) from the balloon and delivering them to the prosthesis pores. The at least one therapeutic agent is then allowed to diffuse through the pores to the lumen wall. | 05-03-2012 |
| 20120116352 | BALLOON ASSISTED OCCLUSION OF ANEURYSMS - A catheter and related methods for percutaneous treatment of an aneurysm, the catheter comprising: an outlet for deploying an occluding agent; and a deflector for deflecting said occluding agent. A second deflector may be provided to cooperate with the first deflector. One of both of the deflectors may comprise inflatable balloons. The occluding agent may comprise a length of wire. | 05-10-2012 |
| 20120116353 | COAXIAL CATHETER INSTRUMENTS FOR ABLATION WITH RADIANT ENERGY - A cardiac ablation instrument capable of removing blood from a treatment area is provided. The instrument includes a catheter configured to deliver a distal end thereof to a patient's heart. The instrument can also include an expandable element coupled to the distal end of the catheter wherein the expandable member is configured to be positioned adjacent a target area thereby defining a treatment area between the expandable member and the target area. Further, the instrument can include an irrigation mechanism configured to dispense an irrigation fluid from the catheter thereby displacing blood from the treatment area. Additionally, the instrument includes an energy emitter configured to deliver energy to tissue within the treatment area. The instrument can also include a contact sensor configured to determine the presence of such blood within the treatment area. Methods for ablating tissue are also provided. | 05-10-2012 |
| 20120123388 | METHOD AND APPARATUS FOR TRANSPORT OF SUBSTANCES INTO BODY TISSUE - Methods and apparatus for delivering a substance to a target tissue are provided which may include any number of features. One feature is storing a substance or drug in a reservoir or reservoirs over an expandable member. The expandable member can be a balloon catheter, for example. The reservoir(s) can be disposed in a Transforming Reservoirs Matrix layer disposed over the expandable member. Another feature is a mechanical activator or a plurality of mechanical activators positioned near the reservoir(s). | 05-17-2012 |
| 20120150147 | SYSTEM AND METHOD FOR TREATING ISCHEMIC STROKE - A system for restoring blood flow through an occluded vessel in the cerebrovasculature is disclosed. The system includes a tubular element constructed of shape memory material eccentrically mounted on the distal end of an introducer. The walls of the tubular element are defined by standards and connectors, and the standards are oriented at an angle to the longitudinal axis of the tubular element. A method of manufacture of the system includes cutting a tube of shape memory material, conferring a twist on the cut tube, and heat setting the tube. The method further includes affixing the shape set tube to an introducer. A method of treatment using the system is also described. | 06-14-2012 |
| 20120165786 | LIPID COATING FOR MEDICAL DEVICES DELIVERING BIOACTIVE AGENT - The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent. | 06-28-2012 |
| 20120172838 | Systems and Methods for Delivering Drugs to Selected Locations Within the Body - Systems and methods for delivering drugs or other substances to target locations outside of blood vessel lumens or other body lumens. In some embodiments, a catheter having a penetrator is advanced into the body lumen and the penetrator is then advanced from the catheter toward a target location outside of that body lumen. The substance is then delivered through a the penetrator itself or through a delivery catheter that has been advanced through the penetrator to the target location. In other embodiments, the blood vessel or other body lumen is blocked at spaced-apart first and second locations and a quantity of the substance is introduced into the closed-off body lumen between the blocked first and second locations. The substance then diffuses into or through the wall of the vessel or body conduit to reach the target location. | 07-05-2012 |
| 20120172839 | DOUBLE WALL CATHETER FOR DELIVERING THERAPEUTIC AGENT - The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly. | 07-05-2012 |
| 20120209250 | NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME - A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen. | 08-16-2012 |
| 20120209251 | NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME - A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen. | 08-16-2012 |
| 20120215202 | MULTICHANNEL CATHETER - An extracorporeal circulation catheter has three independent channels and an expandable balloon at one end of the catheter. The first channel allows for delivery of blood to a patient in an amount sufficient to maintain the patient's metabolism and perfusion throughout the treatment or surgery. The second channel is integrated into the wall of the first channel and is suitable for delivering a fluid (e.g., for cardioplegia) to the heart. A third channel is integrated into the wall of the first channel and is suitable for delivering a fluid to the balloon for its expansion when positioned in the ascending aorta to occlude the flow of blood to the heart. The first channel accounts for at least about 70% of the total channel volume. | 08-23-2012 |
| 20120220982 | Multiple Sclerosis Therapeutic Methods Using Therapeutic Delivery Devices and Systems - Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Multiple Sclerosis or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Multiple Sclerosis or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's internal jugular veins (IJV) or azygous veins (AZV). In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's IJV or AZV veins are provided. | 08-30-2012 |
| 20120239001 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 09-20-2012 |
| 20120259314 | Apparatus and Methods for Recanalization of a Chronic Total Occlusion - A method of recanalizing a chronic total occlusion (CTO) is disclosed. A catheter with a guidewire slidingly received therein is positioned proximally adjacent to the CTO. An occlusion weakening therapy effective to quickly soften and/or loosen the CTO is delivered to the CTO via the catheter. The occlusion weakening therapy includes at least one enzyme and a chelating agent which are selectively deliverable either together or separately depending on the type of material encountered by the guidewire. According to various methods, the enzyme(s) may be delivered if tissue is encountered, the chelating agent may be delivered if calcification is encountered, and both enzyme(s) and chelating agent(s) may be delivered if a fibrous cap is encountered. The distal end of the guidewire may be advanced into the CTO shortly after delivery of the occlusion weakening therapy and is manipulated through the CTO until the guidewire successfully crosses the CTO. | 10-11-2012 |
| 20120259315 | DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME - The present disclosure is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window. | 10-11-2012 |
| 20120271277 | EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION - At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension. | 10-25-2012 |
| 20120277726 | DRUG-ELUTING INSERTABLE MEDICAL DEVICE FOR TREATING ACUTE MYOCARDIAL INFARCTION, THROMBUS CONTAINING LESIONS AND SAPHENOUS-VEIN GRAFT LESIONS - A method for delivering at least one drug at a target site in a blood vessel for treating at least one of an acute myocardial infarction, a thrombus containing lesion and a saphenous-vein graft lesion is disclosed. The method includes delivering nano-carriers at the target site. The nano-carriers include one or more drugs encapsulated with a first biological agent. The nano-carriers further include a second biological agent in contact with one or more of the first biological agent and the one or more drugs. The first biological agent and the second biological agent have a first dissolution rate and a second dissolution rate respectively. The first dissolution rate is different from the second dissolution rate. The one or more drugs are released at the target site from the nano-carriers at a first release rate and a second release rate in response to dissolution of the first biological agent and the second biological agent, respectively. | 11-01-2012 |
| 20120277727 | METHOD AND AN INSERTABLE MEDICAL DEVICE FOR DELIVERING ONE OR MORE PRO-HEALING AGENTS TO A TARGET SITE WITHIN A BLOOD VESSEL POST-DEPLOYMENT OF A STENT - The invention discloses an insertable medical device for delivering one or more pro-healing agents to a site of deployment of a stent in a blood vessel. The surface of the insertable medical device is coated with nano-carriers that include the one or more pro-healing agents encapsulated with one or more biological agents. The nano-carriers are released when the insertable medical device is expanded at the site. The nano-carriers thus released penetrate tissues at the site resulting in dissolution of the one or more biological agents. Thereafter, the one or more pro-healing agents are released from the nano-carriers at the site. Thus, an in-tissue release of the one or more pro-healing agents at the site is achieved thereby improving endothealisation, extracellular matrix formation and healing at the site post deployment of the stent in the blood vessel. | 11-01-2012 |
| 20120283699 | APPARATUS AND METHODS FOR CLOT DISSOLUTION - Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved. | 11-08-2012 |
| 20120289933 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating. | 11-15-2012 |
| 20120296313 | Drug Coated Balloon Hemostatic Valve Insertion/Balloon Sheath - Introducer sheath for use in inserting a balloon catheter into a patient's vasculature includes a tubular member having an inner diameter, an outer diameter, a proximal end, a distal end, and a length therebetween, the inner diameter being sized to receive a catheter shaft having an attached expandable member in a deflated condition. The inner diameter can be varied from a first inner diameter at the proximal end and a second inner diameter at the distal end, the first inner diameter being greater than the second inner diameter. A method of inserting a balloon catheter into the vasculature of a patient is also disclosed. Additionally, a balloon catheter kit including a catheter and an introducer sheath is disclosed. | 11-22-2012 |
| 20120302996 | BALLOON CATHETER AND METHODS OF USE THEREOF - A rapid exchange catheter has an outer conduit and a hollow inner conduit disposed in the lumen of the outer conduit. The inner conduit includes a distal part, a proximal part and a variable length sleeve member sealingly attached between the proximal part and distal part. The distal end of the distal part of the inner conduit extends beyond the distal end of the outer conduit. An inflatable balloon is sealingly attached to the distal end of the outer conduit and to the proximal part of the inner conduit. The balloon intussuscepts upon proximal movement of the distal part of the inner conduit. A pulling member is attached to the distal part of the inner conduit for moving the distal part of the inner conduit proximally to longitudinally shorten the sleeve member. A fluid port allows inflating and deflating the balloon. | 11-29-2012 |
| 20120310210 | ELUTING MEDICAL DEVICES - The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site. | 12-06-2012 |
| 20120330276 | Pulmonary Embolism Therapeutic Methods Using Therapeutic Delivery Devices and Systems - Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Pulmonary Embolism or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Pulmonary Embolism or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's internal pulmonary veins. In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's pulmonary veins are provided. | 12-27-2012 |
| 20130006220 | DRUG COATED BALLOON CATHETER - The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation. | 01-03-2013 |
| 20130035665 | Polymer-Based Occlusion Devices, Systems and Methods - A method of occluding includes imbibing a porous elongate element comprised of ePTFE with a calcium-containing solution. The method also includes delivering, via a delivery catheter, the calcium-imbibed porous elongate element to a target occlusion site. The method further includes administering, after the calcium-imbibed porous elongate element has been completely delivered to the target occlusion site and resides entirely within a volume defined by the target occlusion site, an alginate-containing solution to the target occlusion site. | 02-07-2013 |
| 20130046283 | METHODS AND INTRAVASCULAR TREATMENT DEVICES FOR TREATMENT OF ATHEROSCLEROSIS - Methods and intravascular treatment devices for treating atherosclerosis are provided. | 02-21-2013 |
| 20130053821 | EXPANDABLE CATHETER SYSTEM FOR VESSEL WALL INJECTION AND MUSCLE AND NERVE FIBER ABLATION - A vascular nerve ablation (denervation) system includes a multiplicity of expandable needles which open around a central axis to engage the wall of a blood vessel allowing the injection of a cytotoxic or neurotoxic solution for ablating conducting tissue in and near the vessel wall of a renal artery or pulmonary vein. The expandable needles are formed of self-expanding materials and include structures which limit the distance of penetration of the injection needles into the tissue of the wall of the blood vessel. | 02-28-2013 |
| 20130060234 | INTUSSUSCEPTING BALLOON CATHETER AND METHODS FOR CONSTRUCTING AND USING THEREOF - A catheter including an outer conduit and an inner conduit movably disposed therein. The inner conduit includes at least one movable part. The proximal end of the inner conduit is angled piercing the wall of the outer conduit. The catheter includes an inflatable intussusceptable balloon having a proximal margin attached to the distal tip of the outer conduit and a distal margin attached to a portion of the inner conduit extending beyond the distal tip of the outer conduit. The diameter of a first portion of the balloon is larger than the diameter of other portions thereof. The catheter includes means for axially moving the inner conduit within the outer conduit, means for introducing expansion fluid into the balloon and means for permitting axial movement of the inner conduit within the outer conduit, unhindered by the passage of the angled proximal part of the inner conduit through the outer conduit. | 03-07-2013 |
| 20130102996 | Pressure Activated Foreign Body Removal System and Method of Use - A foreign body retrieval catheter having a distal segment which is movable from a reduced outside diameter for positioning at a target site, and an enlarged outside diameter to suitable for thrombectomy or foreign body retrieval. | 04-25-2013 |
| 20130110081 | DOUBLE BELLOW OCCLUDER FOR SCLEROTHERAPY | 05-02-2013 |
| 20130110082 | CLOT REMOVAL SYSTEM AND METHOD | 05-02-2013 |
| 20130116654 | Aortic Occlusion Catheter - An cardioplegic fluid delivery catheter includes an expandable member for occluding the ascending aorta of a patient. A length of the catheter allows the distal end to be within the ascending aorta while the proximal end extends from a peripheral artery. The delivery catheter has a multi-lumen construction with a primary lumen extending configured to allow a cardioplegic fluid to be delivered to the aorta. Secondary lumens provide for balloon inflation and aortic root pressure monitoring. The delivery catheter includes a shaft having a pre-determined curve profile at a distal end of the delivery catheter. The pre-determined curve profile generally corresponds to the curve of the bottom surface of the aortic arch. The shaft may be eccentric to the expandable member such that retraction of the shaft causes a distal tip to be parallel within the ascending aorta. | 05-09-2013 |
| 20130116655 | BALLOON ASSEMBLIES HAVING CONTROLLABLY VARIABLE TOPOGRAPHIES - Various embodiments provide a device comprising a balloon disposed at least partially along a template, the template including an aperture, wherein the template has a substantially cylindrical portion that resists deformation in a radial direction, wherein the balloon expands radially during inflation, wherein a portion of the balloon at least partially protrudes about the aperture. Other embodiments are directed toward balloons having textured surfaces. | 05-09-2013 |
| 20130123750 | METHODS, COMPOSITIONS AND APPARATUS FOR DELIVERING HETEROLOGOUS MOLECULES TO CELLS - A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's micro vasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the foil length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex. | 05-16-2013 |
| 20130138081 | METHOD AND MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER FOR DELIVERY OF A THERAPEUTIC AGENT - Method of delivering a therapeutic agent includes delivering at least a portion of a medical device within a vasculature. The medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member, a tissue engaging member proximate the expandable member, a sheath disposed over the tissue engaging member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The method further includes deploying the tissue engaging member at a select location by displacement of the sheath relative the tissue engaging member, inflating the expandable member to engage the therapeutic agent with a vessel wall, deflating the expandable member, and withdrawing the medical device from the vasculature. | 05-30-2013 |
| 20130138082 | Intravascular Tissue Disruption - Medical systems and devices adapted to deliver a fluid agent to target tissue within a patient. | 05-30-2013 |
| 20130144263 | BALLOON CATHETER SYSTEM - A balloon catheter system is provided. The catheter includes a first balloon disposed around a second balloon which is movable within the first balloon. | 06-06-2013 |
| 20130158510 | SYSTEM AND METHOD FOR TREATMENT OF HEMORRHAGIC STROKE - Embodiments of the invention provide apparatus, methods and systems for delivering treatments and for medications to the site of an aneurysm (SOA). One embodiment of a method comprises delivering a neural growth stimulating factor (NGSF) to the site of the aneurysm to grow new nerve cells and/or stimulate the regeneration of damaged nerve cells. The NGSF may be delivered in a carrier such as a gel which can be selected to allow for long term delivery of the NGSF to the SOA. In many embodiments, the NGSF may be delivered to the SOA using a micro-catheter based system which includes a microcatheter that can be advanced in the cerebral vasculature. The microcatheter may also be used to delivery occlusive element to the SOA such as occlusive coils or balloon which promote clotting and reduce bleeding at the SOA and together with the carrier allow for long term release of NGSF. | 06-20-2013 |
| 20130158511 | THROMBUS REMOVAL APPARATUS AND METHOD - Thrombus removal apparatus includes a balloon catheter with a short balloon at a distal end thereof. An aspiration catheter is disposed coaxially over the balloon catheter. The balloon catheter includes a plurality of holes for the administration of lytic agent. The apparatus does not seal off completely the zone of the vessel around the thrombus, thereby allowing movement of blood within the vessel. The balloon is shaped so that it can be pulled along the vessel in an upstream direction so as to drag against the vessel walls for assisting in the removal of the thrombus. | 06-20-2013 |
| 20130165903 | METHOD AND APPARATUS FOR CONTROLLED OCCLUSION - A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume. | 06-27-2013 |
| 20130172853 | DRUG DELIVERY MEDICAL DEVICE - Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents. | 07-04-2013 |
| 20130190725 | MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT - Medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member having at least one axial fold in a deflated condition, a tissue engaging member comprising at least one straight wire extending along at least part of the longitudinal axis of the expandable member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The at least one straight wire of the tissue engaging member is located inside the at least one fold of the expanded member when in the deflated condition. The tissue engaging member is configured for deployment at a select location upon inflation of the expandable member. A method of delivering a therapeutic agent is also provided. | 07-25-2013 |
| 20130211381 | DEVICE FOR COMPARTMENTAL DILATATION OF BLOOD VESSELS - A constraining structure for use with a balloon catheter includes multiple longitudinal struts and multiple expandable radial rings. The constraining structure can expand radially but may not expand substantially in the longitudinal direction. The constraining structure can have multiple compartments configured to expand independently of one another. Inflating the balloon catheter within the constraining structure can allow for dilation of the blood vessel in a predetermined topography. | 08-15-2013 |
| 20130218131 | LOCAL DELIVERY WITH A BALLOON COVERED BY A CAGE - A catheter configured for delivering an agent to a patient's vessel wall is described. The catheter includes an inflatable balloon substantially covered by a expandable cage such that when the inflatable balloon is inflated the expandable cage substantially surrounds an outer surface of the inflated balloon. The inflatable balloon is configured to be deployed within a lumen against a lumen wall and separated from the lumen wall by the expandable cage in an expanded state, and is adapted to provide an agent delivery to a treatment site, and the expandable cage is further collapsible and is removable from said lumen. | 08-22-2013 |
| 20130226146 | CLOT REMOVAL SYSTEM AND METHOD - A clot removal system includes an elongated tubular sheath and an elongated tubular catheter received within the sheath. A distal segment of the catheter is split into a plurality of catheter wall segments, with each wall segment having a pre-shaped curved configuration. Each wall segment defines at least one scraping edge and has a distal tip that is less stiff than a remaining portion of the wall segment. The clot removal system has a transport configuration in which the distal segment of the catheter is axially aligned with a distal segment of the sheath and the wall segments are urged against the pre-shaped curved configuration by the sheath. The clot removal system also has a deployed configuration in which the distal segment of the catheter is advanced distally beyond the distal segment of the sheath and the wall segments conform to the pre-shaped curved configuration. | 08-29-2013 |
| 20130231638 | Medical device for dispersing medicaments - For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue. | 09-05-2013 |
| 20130245607 | APPARATUS AND METHODS FOR ACCESSING THE LYMPHATIC SYSTEM - Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. A distal end of a catheter is introduced through the patient's venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member. | 09-19-2013 |
| 20130261601 | INTEGRATED CONTROLLED VOLUME INFLATOR DEVICE, COMPONENTS, AND METHODS OF USE - A controlled pressure inflation-deflation device inflates a balloon to occlude a blood vessel by moving a large plunger to provide incremental pressure increases within a syringe. A releasable latch moves a second plunger, positioned within a syringe formed by an inner columnar opening in the large plunger, between an occlusion position and a perfusion position. A three-position switch has a release position to allow the large plunger to move freely, an adjust position to provide the incremental pressure increases, and a lock position to lock the location of the plunger. Pressures at which various balloons (e.g., folded balloons) achieve or nearly achieve a substantially circular cross-section may be extrapolated by inflating balloons with pressures equal and/or greater than the first occlusion pressure. Balloons may be pre-inflated up to or below the first occlusion pressure to achieve a substantially circular cross-section, prior to increasing the balloon to an occlusion pressure. | 10-03-2013 |
| 20130261602 | RAPAMYCIN COATED EXPANDABLE DEVICES - Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients. | 10-03-2013 |
| 20130281979 | RETROGRADE CARDIOPLEGIA DELIVERY CATHETER AND METHOD FOR INDUCING CARDIOPLEGIC ARREST - A retrograde delivery catheter includes at its distal end an expandable member configured to at least partially occlude the coronary sinus of a patient's heart, and has a length and variable stiffness that allows the distal end to be selectively articulated so as to be positioned in the coronary sinus. The delivery catheter has a triple lumen construction with a primary lumen extending between the proximal and distal ends and configured to allow a cardioplegic fluid to be delivered to the coronary sinus. A second lumen provides for balloon inflation while a third lumen allows monitoring of a pressure within the coronary sinus. A torque may be applied and a reinforcement member within the delivery catheter provides improved torque transmission along the length of the catheter. | 10-24-2013 |
| 20130289528 | THERAPEUTIC DELIVERY DEVICES, SYSTEMS, AND METHODS - Devices, systems, and methods for delivery of therapeutics, in particular thrombolytic agents, in particular plasmin, are provided. The devices, systems, and methods also provide for occlusion of a vessel or graft distal and/or proximal to a treatment zone. Also provided are devices, systems, and methods that trap emboli. | 10-31-2013 |
| 20130304029 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 11-14-2013 |
| 20130338637 | CATHETER SYSTEMS AND METHODS USEFUL FOR CELL THERAPY - Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients. | 12-19-2013 |
| 20130338638 | VASCULAR OCCLUSION AND DRUG DELIVERY DEVICES, SYSTEMS, AND METHODS - Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants. | 12-19-2013 |
| 20140012231 | METHOD FOR ACCESSING A RENAL ARTERY - An elongated hollow tube guiding catheter forming a portion of a guiding catheter includes a proximal end, distal end, and distal section. The distal section includes a curved section and a straight section. The curved and straight sections are shaped for facilitating introduction and retention of the catheter into the ostium of a renal artery. The system includes a dilator inserted into the catheter hollow tube with a curved distal section of the dilator opposingly extending opposite the curved distal section of the guiding catheter hollow tube. The guiding catheter includes a side arm positioned near the guiding catheter's proximal end with a multi-way stop cock fixedly attached onto a proximal end of the side arm tube. | 01-09-2014 |
| 20140031792 | Catheters and Methods for the Treatment of Bodily Passages - Medical devices are described herein. More particularly, the disclosure relates to catheters useful in the treatment of bodily passages, such as an airway, sinus cavity, or sinus passage. The disclosure also relates to methods of treating bodily passages. An exemplary catheter comprises an elongate member having a first balloon and a second balloon. | 01-30-2014 |
| 20140039459 | APPARATUS AND METHOD FOR DELIVERING AN EMBOLIC COMPOSITION - A microcatheter for delivery of embolic fluids includes an outer member dimensioned for insertion within a blood vessel adjacent an embolization site. The outer member defines a first longitudinal lumen, and an inner member is selectively positionable within the first longitudinal lumen of the outer member. The inner member defines a second longitudinal lumen and has a delivery port in fluid communication with the second longitudinal lumen for passage and delivery of embolic fluids toward the embolization site. A valve is disposed within the outer member. The valve is dimensioned to establish a substantial seal about the inner member, to minimize entry of the embolic fluids within the first longitudinal lumen of the outer member subsequent to delivery thereof toward the embolization site. | 02-06-2014 |
| 20140039460 | Transluminal delivery of regenerative cells to body tissue - A method is described for optimizing regenerative cell retention at a tissue site in the body of a subject. In the method, the regenerative cells are delivered to the tissue site through a blood vessel in communication with the site, while blood flow through the vessel is occluded at the site for a prescribed period of sufficient duration to increase pressure at the site for enhanced concentration and retention of the regenerative cells at the tissue site, but of insufficient duration to cause damage to healthy tissue at the site for lack of blood perfusion during the period of occlusion. | 02-06-2014 |
| 20140052104 | TREATMENT DEVICE - A treatment device includes: a balloon; a biologically active agent part applied on an outer surface of the balloon; a protective sleeve encircling the balloon and being displaceable proximally; and an interposed member having a self-expanding function arranged between the balloon and the protective sleeve. When the protective sleeve is moved proximally in order for the balloon to be exposed to the inside of a blood vessel, the presence of the interposed member prevents the biologically active agent part from being scraped and peeled off by THE inner surface of the protective sleeve. | 02-20-2014 |
| 20140058357 | Apparatus for Peripheral Vascular Access - This invention provides devices and methods for insertion of a catheter into a vessel. The devices include coaxial slidably mounted needle, dilator and catheter components. The methods include piercing a vessel with the needle component, dilating the pierced hole with the dilator component, retraction of the needle component, insertion of the catheter and withdrawal of the dilator. | 02-27-2014 |
| 20140058358 | DRUG ELUTING SCULPTING BALLOON - A plaque-modifying balloon and method for use in an endovascular procedure includes an elongated balloon that defines a longitudinal axis and is inflatable from a first deflated configuration to a second radially expanded configuration. One or more plaque-modifying elements are mounted on the outside of the inflatable balloon. Optionally, a compressible sheath made of a relatively low durometer, flexible material is mounted on the balloon to cover the elements during transit of the plaque-modifying balloon to and from the treatment site. | 02-27-2014 |
| 20140066895 | ANATOMIC DEVICE DELIVERY AND POSITIONING SYSTEM AND METHOD OF USE - An anatomic device delivery and positioning system has a stabilizing guide wire for placement of a catheter or other medical device or material into a vessel or cavity of a tissue or organ within a body of a living subject into which the guide wire is insertable. The guide wire includes an elongated member having a proximal end and a distal end, the proximal end to extend out of the body and the distal end to extend into the body, the distal end having an expandable portion that expands from a compressed condition when inside of a delivery tube or catheter to an expanded condition when outside of the delivery tube or catheter. A method is also disclosed of performing a percutaneous procedure within a vessel or cavity of a tissue or organ of a subject using the guide wire, particularly but not exclusively involving a heart procedure. | 03-06-2014 |
| 20140066896 | INFLATABLE MEDICAL DEVICES - An inflatable structure for use in biological lumens and methods of making and using the same are disclosed. The structure can have an inflatable balloon encircled by a shell. The shell can have proximal and distal tapered necks, longitudinally-oriented flutes, and apertures at the proximal and distal ends of the shell. The apertures can be recessed in the flutes in the necks. The shell can also have fiber reinforced walls. | 03-06-2014 |
| 20140066897 | RETRACTABLE SHEATH DEVICES, SYSTEMS, AND METHODS - The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site. | 03-06-2014 |
| 20140066898 | RETRACTABLE SHEATH DEVICES, SYSTEMS, AND METHODS - The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only upon necking of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site. | 03-06-2014 |
| 20140094777 | DUAL PURPOSE BALLOON CATHETERS - Enhanced dual purpose systems enable dilating of at least a lesion within a blood vessel and providing an anti-proliferative medicament in a non-attached form directly into the lumen of the vessel. Likewise provided is the ability to stop blood flow to prevent wash-out of the medicament during dwell time within the body lumen, and the ability to remove the medicament after the dwell time of the device to prevent unwanted exposure of the same within the body. | 04-03-2014 |
| 20140121640 | MULTIPURPOSE MEMBRANES, METHODS FOR FORMING, AND APPLICATIONS THEREOF - One aspect of the present disclosure relates to a method for forming a multipurpose membrane in vivo. One step of the method includes obtaining a blood component. Next, a vacuum assembly is operated to remove substantially all of the liquid from the blood component and thereby form a concentrated, substantially dehydrated blood component. The substantially dehydrated blood component is then formed into a non-coagulated injectable composition and administered to a wound of a subject. | 05-01-2014 |
| 20140121641 | TRANSVASCULAR CATHETER FOR EXTRAVASCULAR DELIVERY - An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through guide tubes which may be supported by an expandable balloon. The guide tubes expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The diameter of the inflated balloon is less than the inside diameter of the vessel, allowing perfusion across the inflated balloon and guide tubes. | 05-01-2014 |
| 20140128844 | DEPLOYMENT MECHANISM FOR BODY VESSEL INSERTION DEVICES - An aspect of some embodiments of the invention relates to a microcatheter comprising a deployment element disposed about around at least a portion of an exterior of a distal end of the microcatheter, the deployment element configured for repeatedly expanding and collapsing, the distal end arranged to allow forward or reverse axial displacement while the deployment element maintains a position, the deployment element arranged for positioning the microcatheter distal end approximately in the middle of a vessel. A method of traversing tortuous vessels using the microcatheter, in accordance with an exemplary embodiment of the invention, is also described. | 05-08-2014 |
| 20140142547 | HEMOSTATSIS-ENHANCING DEVICE AND METHOD FOR ITS USE - The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body. | 05-22-2014 |
| 20140142548 | SYSTEMS, DEVICES AND METHODS FOR RESUSCITATION - Methods, devices, systems of resuscitating a patient including accessing an arterial vessel positioning a catheter into the arterial vessel advancing the catheter through the arterial vessel to position it below a vessel supplying blood to a heart and a brain expanding an expandable portion of the catheter to prevent blood from flowing past the expanded portion and infusing a substance retrograde into the artery within the arterial section between the heart and the expanded portion of the catheter. | 05-22-2014 |
| 20140148789 | METHODS AND APPARATUS FOR SECURING A MEDICAL CLAMP TO A PATIENT - Methods and apparatus for actuating first and second fasteners to secure a medical clamp to a patient. An exemplary fastening device comprises a first rotatable member configured to rotate from an outward position to an inward position to engage the first fastener and a second rotatable member configured to rotate from an outward position to an inward position to engage the second fastener. The first and second rotatable members are mechanically coupled to enable concurrent engagement of the first and second fasteners. | 05-29-2014 |
| 20140163525 | Balloon With Fibers for Treatment of Blood Vessels - The disclosed subject matter describes systems and methods of delivering a therapeutic agent, such as a sclerosing agent, to the walls of a blood vessel to perform sclerotherapy. In an exemplary embodiment a catheter includes a balloon having an inner and outer surface defining a wall, and an interior volume with an unexpanded and expanded configuration and a plurality of fibers extending from the outer surface of the balloon wall. In another exemplary embodiment, a balloon catheter comprises a catheter having a balloon with an unexpanded and an expanded configuration, and a retractable sheath disposed on the exterior surface of the balloon, wherein the sheath has an inner surface and an outer surface, and further wherein a plurality of fibers outwardly extend from the outer surface of the sheath. | 06-12-2014 |
| 20140171911 | APPARATUS AND METHODS FOR CLOT DISSOLUTION - Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved. | 06-19-2014 |
| 20140171912 | DRUG-ELUTING ANGIOPLASTY BALLOON SYSTEMS - Systems, devices, and methods are provided for drug-eluting angioplasty balloons. An underlying balloon core member is protected by a core-screen from mechanical and flow shear forces during delivery. Inflation of the balloon opens the screen and pores in the screen permitting drug transfer and absorption. Upon deflation, the screen can be compressed and withdrawn with the balloon. | 06-19-2014 |
| 20140180247 | Catheter Assembly With Cuff Deployment Device - A catheter assembly includes a catheter having an elongate tubular body defining a lumen extending from an open proximal end to an open distal end. A cuff deployment device is concentrically supported on the elongate tubular body and is movable along a longitudinal axis of the elongate tubular body. The cuff deployment device includes a deployment mechanism having an actuated position and a non-actuated position. A cuff has a hollow cylindrical body defining an internal catheter engagement surface. The catheter assembly has a first configuration in which the deployment mechanism is in the non-actuated position and the cuff is supported by and movable with the cuff deployment device, and a second configuration in which the deployment mechanism is in the actuated position and the cuff is concentrically mounted at a fixed axial location of the elongate tubular body and is free of contact with the cuff deployment device. | 06-26-2014 |
| 20140180248 | Osmotic Ablation Device - A tissue ablation device comprising a balloon catheter, or other expandable element, wherein said expandable element is comprised of a semipermeable membrane. The balloon membrane is expanded by an osmotically active solution to contact a vascular endothelium, or other desired tissue, whereupon the resultant osmotic gradient affects a water flux from the vascular endothelium, or other desired tissue, across the semipermeable membrane and towards the osmotically active solution. | 06-26-2014 |
| 20140180249 | VARIABLE LENGTH CATHETER FOR DRUG DELIVERY - A method for localized delivery of a therapeutic or diagnostic agent within a vessel is provided. The method provides for adjustability of the length of the treatment area and for reducing of pressure within the treatment area. A catheter system includes an inner elongated element, an outer elongated element positioned coaxially with respect to the inner elongated element, and a blood-release element at a distal end of the inner elongated element. A proximal occlusion element is positioned at the distal end of the outer elongated element, proximal to an outlet port. A distal occlusion element is positioned at a distal end of the inner elongated element. The distal end of the inner elongated element is distal to and movable with respect to the outer elongated element distal end. | 06-26-2014 |
| 20140200550 | TWO-PIECE TRANSSEPTAL CANNULA, DELIVERY SYSTEM, AND METHOD OF DELIVERY - A cannula assembly for directing blood from the heart of a patient and a minimally invasive method of implanting the same. The cannula assembly includes a flexible cannula body having a proximal end and a distal end with a receiving portion, and a transseptal tip having a distal end and a proximal end with an engaging portion. First and second anchors are coupled to the transseptal tip and configured to be deployed from a contracted state to an expanded state. The engaging portion of the transseptal tip is operable to removably engage the receiving portion of the flexible cannula body in vivo. | 07-17-2014 |
| 20140207107 | METHOD FOR INFUSING STEM CELLS - A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid. | 07-24-2014 |
| 20140214002 | BIFURCATION CATHETER WITH VARIABLE LENGTH OCCLUSION ELEMENTS - There is provided a catheter for providing a delivery substance to a bifurcated vessel, and isolating a treatment zone within the bifurcation. The catheter includes a proximal shaft and a first and second distal shaft positioned within the proximal shaft. The proximal shaft has a proximal occlusion element at a distal end thereof, the first distal shaft has a first distal occlusion element at a distal end thereof, and the second distal shaft has a second distal occlusion element at a distal end thereof. When the proximal occlusion element, and the first and second distal occlusion elements are deployed, a treatment zone is defined, and a delivery substance may be introduced into the treatment zone via the proximal shaft. | 07-31-2014 |
| 20140214003 | Guidewire and Catheter System and Method for Treating a Blood Clot - A system for treating a blood clot includes a microcatheter extending through an optional aspiration catheter, and a guidewire subassembly extending through and beyond the microcatheter, the guidewire assembly having a guidewire, an element coupled to and extending around a portion of the guidewire, and a balloon coupled to and extending around the element. The balloon includes or is coupled to a proximal seal in contact with the inner surface of the microcatheter and has at least one radially arranged pore. Infusate flows through the microcatheter into the element and between the element and the guidewire, and out and into the balloon to pressurize the balloon. The infusate escapes the balloon through the pores. | 07-31-2014 |
| 20140221976 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating. | 08-07-2014 |
| 20140221977 | SYSTEMS AND METHODS FOR NEEDLE AND CATHETER ADVANCEMENT - Intravenous access is achieved by introducing a catheter over an access needle which is initially present in the catheter. A tapered dilating element is positioned over the needle and provides a transition between the needle and a larger catheter lumen. The access needle is hollow and has a port which allows blood to flash back through a lumen of the catheter so that flashback can be observed on a catheter hub or the catheter itself. | 08-07-2014 |
| 20140221978 | Balloon Catheter Systems for Delivery of Dry Drug Delivery Vesicles to a Vessel in the Body - Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon. | 08-07-2014 |
| 20140243790 | APPARATUS AND METHODS FOR ACCESSING THE LYMPHATIC SYSTEM - Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. An apparatus is provided that includes a catheter including proximal and distal ends and a lumen extending therebetween. An expandable sealing member is carried beyond the distal end that is expandable from a delivery condition to a deployed condition in which the sealing member defines a concave contact surface shaped for engaging a vessel wall surrounding the outlet of the thoracic duct. The sealing member includes an aspiration port in the contact surface communicating with the catheter lumen for removing fluid from the thoracic duct. | 08-28-2014 |
| 20140249506 | HELICAL BALLOON CATHETER - Methods and devices described for improved catheters including those having a deflectable section to allow for expansion while maintaining flow through a vessel. | 09-04-2014 |
| 20140257245 | Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders - Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot. | 09-11-2014 |
| 20140276608 | BALLOON SCLEROTHERAPY - Disclosed are methods, devices, and systems for treating a body lumen with a sclerothepeutic agent. The method includes the steps of positioning a porous balloon assembly at a site in the lumen to be treated, inflating the assembly to establish a close approximation to the lumen wall, forcing the sclerotherapeutic agent to exit the pores and come in contact with the lumen wall, and to deflate and retrieve the balloon assembly. The methods, devices and systems disclosed herein are especially useful for the treatment of incompetent veins and their contributory branches. | 09-18-2014 |
| 20140276609 | Fetal Intervention Using Magnetically-Guided Navigation - Methods and systems for fetal intervention to address malformations or other conditions are presented. In one instance, a method is provided that includes introducing a guide catheter into the fetus' venous system and using controlled magnets to position the guide catheter at a desired location. The method also involves positioning the treatment catheter at a treatment location using the guide catheter and delivering a treatment using the treatment catheter at the treatment location. In one particular application, a hypoplastic left heart is treated by using a balloon catheter as the treatment catheter and inflating a balloon on the balloon catheter at the aortic valve. Other methods and systems are disclosed. | 09-18-2014 |
| 20140276610 | DELIVERY DEVICES AND RELATED METHODS OF USE - A medical device including an outer balloon, an inner balloon, and at least one delivery unit is disclosed. The outer balloon defines a first internal cavity that remains in fluid communication with a first inflation lumen. The inner balloon is disposed within the first internal cavity, and defines a second internal cavity that is in fluid communication with a second inflation lumen. Each delivery unit includes at least one needle configured to pierce a tissue and at least one reservoir containing a material. Further, inflation of the outer balloon or the inner balloon is structured and arranged to deliver the material into the tissue through the needle lumen. | 09-18-2014 |
| 20140343536 | SEQUENTIALLY INFLATABLE BALLOONS FOR DELIVERY OF TREATMENT AGENTS - An apparatus including a cannula having a dimension suitable for insertion into a blood vessel and an expandable body coupled thereto, the expandable body comprising a first expandable member and a second expandable member to isolate a length of the vessel upon expansion within the blood vessel. The expandable body having an intermediate expandable member along a working length between the first expandable member and the second expandable. A method including introducing a cannula and an expandable body coupled thereto into a blood vessel at a point coextensive with a treatment site and expanding a first expandable member and a second expandable member of the expandable body to isolate a length of the vessel adjacent the treatment site. The method further including delivering a treatment agent to a vessel region between the first expandable member and the second expandable member while inflating and deflating an intermediate expandable member. | 11-20-2014 |
| 20140350522 | DRUG DELIVERY MEDICAL DEVICE - Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents. | 11-27-2014 |
| 20140350523 | AORTIC OCCLUSION DEVICE - Embodiments of aortic occlusion devices are described herein that include radially expandable and collapsible proximal and distal end portions, such as annular self-expanding stents or frames, that are configured to radially expand within an aorta to secure the device within the aorta. The devices can also include a catheter extending axially between the distal end portion and the proximal end portion and a porous covering, or filter, positioned around the catheter and between the proximal end portion and the distal end portion and configured to filter emboli from blood flowing into upper-body arteries. The device can further include a one-way valve positioned at or adjacent to the distal end portion of the device and configured to restrict retrograde blood flow through the device toward the heart. | 11-27-2014 |
| 20140350524 | Wire Guide Engagement And Withdrawal Tool And Method - A tool for engaging and withdrawing a wire guide from a patient includes a deformable distal segment having a self-expanding bias such that the distal segment assumes a tortuous configuration, and a control line attached to the distal segment and configured to extend through an intraluminal sheath, such that pulling the control line deforms the distal segment in opposition to the self-expanding bias to tighten about a wire guide. The tool may be withdrawn from the patient while tightened about the wire guide, such that the wire guide simultaneously extends out of the patient at each of a first and a second percutaneous entry point. | 11-27-2014 |
| 20140358122 | DRUG COATING LAYER - A drug coating layer which is a drug coating layer having a morphological form including a plurality of elongated bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongated bodies are nearly linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect. | 12-04-2014 |
| 20140364834 | Weeping Balloon Catheter With Drug Delivery Through Dilation Balloon - A weeping balloon catheter includes a catheter having an elongate tubular body defining a medical device lumen and a liquid delivery lumen. A dilation balloon is disposed at a distal end of the elongate tubular body and is in fluid communication with the liquid delivery lumen. The dilation balloon includes a fluid communication channel through an outer wall of the dilation balloon. A flow restriction member is positioned along the fluid communication channel and has an open position permitting fluid communication along the fluid communication channel and a closed position blocking fluid communication along the fluid communication channel. A drug delivery path of the weeping balloon catheter is defined by the liquid delivery lumen and the dilation balloon. | 12-11-2014 |
| 20140364835 | DEVICE AND METHODS FOR TRANSVASCULAR TUMOR EMBOLIZATION WITH INTEGRATED FLOW REGULATION - A catheter assembly may be provided with a catheter body and an inflatable balloon. The catheter body has a proximal end, a distal end and a balloon inflation lumen. The inflatable balloon is attachable to the distal end of the catheter body. The balloon has an inner surface that at least partially defines an interior volume. The balloon is configured such that the interior volume can be in fluid communication with the inflation lumen of the catheter body to inflate the balloon. The balloon also has a proximal surface and a distal surface. The balloon is provided with a channel that extends through the balloon. The channel is configured to provide fluid communication between the proximal surface of the balloon and the distal surface of the balloon. Other catheter assemblies and methods of use are also disclosed. | 12-11-2014 |
| 20140371716 | CATHETER-BASED CANCER THERAPY - An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely. | 12-18-2014 |
| 20140371717 | DRUG DELIVERY MEDICAL DEVICE - A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device. | 12-18-2014 |
| 20150032086 | BALLOON CATHETER SYSTEMS AND METHODS - The embodiments disclosed herein relate to balloon catheter assemblies. The balloon catheter assemblies can include a hub, an elongated member, and an inflation balloon. The balloon catheter assemblies can also include a support wire having a proximal end that is longitudinally displaceable within a sleeve that is disposed in the catheter hub. A distal end of the support wire may be coupled to the inflation balloon at one or more positions. | 01-29-2015 |
| 20150032087 | DEVICE FOR TREATING LUMEN OF LIVING BODY - A device for treating the lumen of a living body includes a shaft insertable into a blood vessel, and a balloon provided on the shaft and shiftable between a deflated state and an expanded state. In the expanded state, the balloon has a recessed portion configured to form a coating chamber which is substantially blocked between an inner surface of the blood vessels and the device for treating the lumen of a living body, a discharge port provided on the recessed portion to discharge a coating substance toward the coating chamber; and a suction port provided on the recessed portion to apply a negative pressure to the coating chamber. | 01-29-2015 |
| 20150073388 | DRUG DELIVERY SYSTEMS AND RELATED METHODS - The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body. | 03-12-2015 |
| 20150126965 | ASSEMBLY WITH A GUIDE TUBE, A FIXATOR FOR ATTACHING TO A BLOOD VESSEL, AND A PUMP - A fixator assembly comprising a fixator for fixing inside a blood vessel, a guide tube attached to the fixator and a pump for supplying a liquid to the blood vessel or from the blood vessel via the guide tube. Blood flow past the fixator is possible during pumping so that critical situations are avoided. A method of providing a liquid to a blood vessel using the assembly is also claimed. Sampling or liquid dosing thus may be performed during extended periods of time while performing this at a well-defined position in the blood vessel and potentially close to or at the desired position in the person. | 05-07-2015 |
| 20150126966 | BALLOON CATHETER - A rapid exchange balloon catheter including: an outer conduit having a lumen and a wall surrounding the lumen, the wall including a lateral opening formed therein; an inner conduit having a proximal end and a distal end; a sealing sleeve for sealing the lateral opening of the outer conduit; a balloon whose proximal margin is attached to the outer surface of the distal end of the outer conduit, and whose distal margin is attached to the outer surface of the portion of the inner conduit that extends beyond the distal end of the outer conduit; a pushing-pulling mechanism disposed in the outer conduit; and a fluid port for the introduction of an expansion fluid and for the removal of the expansion fluid. | 05-07-2015 |
| 20150133891 | CATHETER SECUREMENT DEVICE AND METHODS - A catheter securement device includes a body having a generally curved channel configured to receive a central venous catheter and reposition it in a different direction than the direction of the catheter as it exits the skin of the patient. The securement device includes a cover that slidably connects to the securement device body to prevent the catheter from being pulled out of the curved channel. | 05-14-2015 |
| 20150133892 | METHOD AND DEVICES FOR FLOW OCCLUSION DURING DEVICE EXCHANGES - A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury. The inflatable balloon can be inflated and deflated through a valve positioned at the proximal end of the guide wire. | 05-14-2015 |
| 20150148780 | MEDICAL BALLOON WITH A PRECISELY IDENTIFIABLE PORTION - A balloon catheter includes an elongated, tubular shaft extending in a longitudinal direction, said shaft having a proximal end and a distal end. A balloon having an inflation compartment is formed a balloon wall including a working surface, and further includes at least one chamber adjacent to the working surface adapted for receiving an identifier for identifying the location of the working surface. Related aspects are also disclosed. | 05-28-2015 |
| 20150306360 | Rotational Localized Drug Delivery Device - A drug delivery device that uses centrifugal force to deliver a drug to a body lumen wall. The drug delivery device comprises an impeller that includes an impeller shaft; an impeller head at the distal end of the impeller shaft; a drug lumen; an impeller housing; and a housing shaft attached to the impeller housing. In use, the drug is advanced along the drug lumen to the impeller head; at least the impeller head is rotated so that when drug exits the drug lumen, the centrifugal force of the rotating impeller causes the drug to move radially outward from the drug delivery device, towards and into the body lumen wall. | 10-29-2015 |
| 20150306361 | BALLOON CATHETER AND METHODS OF USE THEREOF - A balloon catheter including a shaft and an inflatable balloon attached to the shaft, the catheter includes an open sleeve having a proximal end sealingly attached to the catheter shaft and an open distal end. The sleeve surrounds at least part of the balloon. The sleeve and the balloon are arranged such that inflating the balloon expands the sleeve into an expanded state and deflating the balloon when the sleeve is in the expanded state forms an open cavity between the sleeve and the deflated balloon and creates suction to capture and retain debris within the cavity. | 10-29-2015 |
| 20150314111 | VARIABLE LENGTH CATHETER FOR TREATING A VESSEL CONTAINING THROMBUS - A system and method for treating a vessel is provided. A catheter system includes an inner elongated element and an outer elongated element positioned coaxially with respect to the inner elongated element. A proximal occlusion element is positioned at and is flush with the distal end of the outer elongated element. A distal occlusion element is positioned at a distal end of the inner elongated element. The distal end of the inner elongated element is distal to and movable with respect to the outer elongated element distal end. One or both of proximal occlusion element and distal occlusion element is a compliant balloon, configured to form a funnel shape upon proximal movement of the outer elongated element and/or the inner elongated element. | 11-05-2015 |
| 20150320981 | Catheter System for Venous Infusions - A system for anchoring a distal end of a catheter at a treatment site includes an elongated catheter shaft that is formed with a lumen and a cone shaped balloon membrane. For the system, the proximal and distal ends of the balloon membrane are affixed to an outer surface of the shaft to establish a balloon having an inflation chamber between the membrane and the shaft. A first membrane portion extends from the distal membrane end to a balloon membrane midsection and a second membrane portion extends from the midsection to the proximal membrane end. To establish the proper shape for the inflated balloon, the second membrane portion is configured to establish a cone angle, α, (relative to a proximally directed portion of the longitudinal axis) that is less than or equal to ninety degrees (α≦90 degrees). A second embodiment includes two cone shaped balloons. | 11-12-2015 |
| 20150328369 | METHOD OF TREATING PERIPHERAL ARTERY DISEASES IN LOWER LIMBS - A method of treating peripheral artery diseases in lower limbs by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a high drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later low drug-concentration period of time. | 11-19-2015 |
| 20150328371 | METHOD OF REDUCING THE RISK OF EMBOLIZATION OF PERIPHERAL BLOOD VESSELS - A method of reducing the risk of embolization of peripheral blood vessels by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystal particles are transferred to the blood vessel wall, and deflating the expandable member such that the generation of microparticulates having a size that causes embolization of peripheral blood vessels is suppressed. | 11-19-2015 |
| 20150328372 | METHOD OF INHIBITING THICKENING OF VASCULAR INTIMA - A method of inhibiting thickening of vascular intima by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a vascular intima thickening is inhibited uniformly in an entire treated lesion of stenosis to uniformly cause patency of the lesion. | 11-19-2015 |
| 20150335384 | METHODS OF ABLATING TISSUE USING A CATHETER INJECTION SYSTEM - At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension. | 11-26-2015 |
| 20150343178 | AUGMENTED DELIVERY CATHETER AND METHOD - The present invention relates to a catheter apparatus with an anchoring device to stabilize the catheter tip when in use, such as when infusing, injecting, or delivering substances, devices or other catheters into a patient. The apparatus according to various embodiments deploys an anchoring device that stabilizes the catheter tip and enables adjustment of the blood flow during use. | 12-03-2015 |
| 20150359433 | IMAGE GUIDED THERAPEUTIC CATHETER WITH DRUG ELUTING BALLOON - An integrated therapeutic and imaging catheter includes an imaging device and drug eluting balloon (“DEB”) assembly. The DEB assembly is a balloon assembly having its outer surface coated with a drug eluting coating. In operation, the DEB catheter is inserted into a patient's vessel, whereby the vessel walls are imaged by the imaging device. After identification of a treatment area within the vessel, the DEB assembly is inflated to apply the drug eluting coating to the treatment area. After application, the treatment area and the drug eluting coating may be re-imaged in order to determine if the treatment area was sufficiently coated. If the treatment area is found to be insufficiently coated, the DEB assembly may be re-inflated to thereby sufficiently coat the treatment area. | 12-17-2015 |
| 20150359998 | INFUSION CATHETER WITH GUIDEWIRE VALVING - The present disclosure relates to a PTA (percutaneous transluminal angioplasty) balloon catheter, preferably high pressure type, optionally introducible as an over the wire catheter. The catheter possess the attribute of injecting fluid to the treated site through a dedicated opening proximal to the balloon member, for introduction of fluids such as contrast enhancing material and/or medication. In some embodiments, a single lumen is used, at least in part, both for fluids transfer and dispersion (“infusion”) as well as for guide wire passage. In some such embodiments, a valve mechanism is used to sustain selective operability of the lumen so that fluids will disperse mostly or solely through the proximal dispersion opening rather than the guide wire distal exit opening. | 12-17-2015 |
| 20160000975 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue. | 01-07-2016 |
| 20160015861 | DRUG COATING LAYER - Provided are a drug coating layer which has low toxicity and a high intravascular stenosis inhibitory effect, when delivering medical device coated with a drug into the body and medical device using the same. The drug coating layer is a drug coating layer having a morphological form including a plurality of elongated bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongated bodies are nearly linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. | 01-21-2016 |
| 20160015864 | COATING COMPOSITION AND MEDICAL DEVICE - A coating composition capable of forming a drug coating layer unsusceptible to peeling in the process of delivery of a water-insoluble drug to a target tissue is provided. The coating composition contains the water-insoluble drug and a basic compound which is positively charged at physiological pH. A medical device coated with the coating composition is further provided. | 01-21-2016 |
| 20160030068 | METHOD FOR TREATING VARICOSE VEINS AND INTRALUMINAL DEVICE USED IN SUCH METHOD - A method of treating a varicose vein involves inserting the distal portion of an intraluminal device into a varicose vein, wherein the device includes an elongated outer sheath and an expandable expansion member at the distal end of the outer sheath. The method also involves relatively moving the distal and proximal ends of the expandable spiral expansion member to reduce the distance between the distal and proximal ends of the expansion member and cause the expansion member positioned inside the varicose vein to outwardly expand to an expanded expansion member comprising a plurality of contact members in contact with the inner wall of the varicose vein. The method further includes axially moving the expanded expansion member while the contact members are in contact with the inner wall of the varicose vein and rotating the expanded expansion member during the axial movement. | 02-04-2016 |
| 20160030714 | DEVICES AND METHODS FOR PERFUSING AN ORGAN - The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region. | 02-04-2016 |
| 20160030719 | METHOD FOR TREATING VARICOSE VEINS AND INTRALUMINAL DEVICE USED IN SUCH METHOD - A method of treating a varicose vein involves inserting the distal portion of an intraluminal device into a varicose vein, wherein the device includes an elongated outer sheath and an expandable expansion member at the distal end of the outer sheath. The method also involves relatively moving the distal and proximal ends of the expandable spiral expansion member to reduce the distance between the distal and proximal ends of the expansion member and cause the expansion member positioned inside the varicose vein to outwardly expand to an expanded expansion member comprising a plurality of contact members in contact with the inner wall of the varicose vein. The method further includes axially moving the expanded expansion member while the contact members are in contact with the inner wall of the varicose vein and rotating the expanded expansion member during the axial movement. | 02-04-2016 |
| 20160058915 | Medical Balloon Coated With Therapeutic Agent, Carboxylic Acid, and Salt Thereof - A coated medical balloon that includes a polymeric material having a surface with a therapeutic agent-containing mixture coated thereon, wherein the mixture includes a therapeutic agent, an unsaturated carboxylic acid, and a salt of the unsaturated carboxylic acid. | 03-03-2016 |
| 20160058983 | Peelable Protective Sheath - A peelable protective sheath and related assemblies/systems and methods are disclosed. The protective sheath may be used on a balloon catheter to protect the balloon and any coating thereon. The protective sheath may be peelable to make removal of the protective sheath easier. The peelable protective sheath may be inserted into a hemostatic valve and introducer while still disposed over the balloon of a balloon catheter to protect the balloon and any bioactive coating thereon from damage during insertion. The peelable protective sheath may be peeled from a proximal end to initiate removal. Alternatively, the peelable protective sheath may be peeled from a distal end of the peelable protective sheath as the balloon catheter is inserted through a hemostatic valve and introducer. | 03-03-2016 |
| 20160058984 | FLEXIBLE LOW COMPLIANCE EXTENSION TUBING FOR BALLOON INFLATION - A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume. | 03-03-2016 |
| 20160095961 | CROSSLINKED COATINGS DELIVERED BY A BALLOON - The present invention relates to systems for and corresponding methods of delivering a therapeutic agent to a vessel wall of a body lumen by providing a compound capable of being crosslinked after intraluminal release onto a vessel wall so that the therapeutic agent is temporarily retained at the site of delivery by the crosslinked compound. | 04-07-2016 |
| 20160121027 | Formulations for Tailored Drug Release - The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices. | 05-05-2016 |
| 20160151612 | Drug Delivery Balloon Apparatus and Methods for Use | 06-02-2016 |
| 20160158489 | SELF-EXPANDING CANNULA - Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient. | 06-09-2016 |
| 20160158506 | PERIPHERAL ANTEGRADE PERFUSION AND OCCLUSION DEVICE - This disclosure relates generally to systems and methods for occluding vessels of the heart and inducing cardioplegic arrest to facilitate the performance of cardiac procedures. An aortic occlusion and perfusion device includes an expandable member configured to expand within the aorta to secure the device within the aorta, and a catheter extending proximally from the expandable member and in fluid communication with the expandable member. The catheter can define a plurality of openings along its length through which blood can pass with one or more of the openings located proximal to the expandable member and one or more of the openings located within the expandable member. The device can also include a flow control sheath disposed around the catheter member such that axial movement of the flow control sheath relative to the catheter selectively occludes or uncovers one or more of the openings located proximal to the expandable member. | 06-09-2016 |
| 20160175569 | DEVICE FOR TREATING VASCULAR OCCLUSION | 06-23-2016 |
| 20160199624 | Balloon Catheter Systems for Delivery of Dry Drug Delivery Vesicles to a Vessel in the Body | 07-14-2016 |
| 20160249942 | INSERTABLE MEDICAL DEVICE SYSTEM WITH PLAQUE TREATMENT PORTION AND METHODS OF USING | 09-01-2016 |
| 20160375230 | DEVICES AND METHODS FOR TREATING ACUTE KIDNEY INJURY - A catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially the contrast-induced acute kidney injury wherein the devices prevent the contrast dyes from entering into kidney and/or facilitate blood flow of kidney by said catheter system. | 12-29-2016 |
| 20170232238 | MULTI-LUMEN CANNULAE | 08-17-2017 |
| 20220133343 | Retrograde Blood Flow Occlusion Flushing Device - A device and method for establishing retrograde blood flow during recanalization of a vessel having a targeted blockage. While in a collapsed state an occluding component is introduced distally intravascularly traversing the targeted blockage to its distal side. Then, the occluding component transitions to an expanded state having an enlarged diameter forming a seal with an internal wall of the vessel prohibiting anterograde blood flow beyond the expanded occluding component. Retrograde blood flow is thereby established in a region of the vessel bound at one end by the occluding component and at an opposite end by the targeted blockage by dispensing a flushing fluid into the region of the vessel. | 05-05-2022 |
