| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 604046000 | Treating material introduced into body by contact with wound formed therein by solid scarifier, cutter, or the like (e.g., scratching skin with vaccine coated needle, etc.) | 55 |
| 20080262416 | Microneedle Arrays and Methods of Preparing Same - A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array. | 10-23-2008 |
| 20080269670 | Skin Penetrating Touch Fasteners - A skin attachment member having first and second surface with a plurality of skin penetrating elements extending integrally from the first surface of the backing to a distal tip. The skin penetrating elements are sized to avoid contact with nerves below the epidermal skin layer and have a foam disposed between at least some of the skin penetrating elements. A method of using the skin attachment member to deliver a pharmaceutical composition through the skin. | 10-30-2008 |
| 20080312583 | TOPICAL COMPOSITION FOR TREATING PAIN - Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness. | 12-18-2008 |
| 20090036826 | METHOD AND DEVICE FOR ABRADING SKIN - A device includes a plurality of microneedles for abrading the stratum corneum of the skin to form a plurality of grooves in the tissue having a controlled depth and width. The microneedles have a length of about 5-250 microns and generally about 5-200 microns. The device is rubbed over the skin to prepare an abraded site after which a transdermal delivery or sampling device is applied to the abraded delivery site. The abrasion increases the permeability of the skin and the rate of delivery and extraction of a substance without pain or irritation to the patient. | 02-05-2009 |
| 20090137945 | Electro Collagen Induction Therapy Device - A device for creating a plurality of small wounds in a patient's skin and introducing topically-applied substances therein is disclosed. The device comprises a rigid plate that has a top side, a bottom side, and at least one peripheral edge that connects the top and bottom sides. The device further includes a tool attachment means fixed with the top side of the plate and adapted to fix the device to a motorized tool that oscillates reciprocally back and forth along the longitudinal axis of the plate. A plurality of needles project generally orthogonally away from the bottom side of the plate. In use, the plate is fixed with the tool and the tool activated. The bottom side of the plate is then applied to the skin of the patient such that each needle repeatedly pierces same to create the plurality of small wounds therein. When the substance is applied to the skin first, each needle draws a portion of the substance into the skin with each oscillation of the tool. | 05-28-2009 |
| 20100152649 | Apparatus and method for transdermal delivery of parathyroid hormone agents - An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member. | 06-17-2010 |
| 20110034867 | MICROTHREAD DELIVERY SYSTEM - Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium). | 02-10-2011 |
| 20120065582 | DEVICES AND METHODS FOR SECURING TISSUE - A compression ring to grip and compress body structure such as diverticulum, hemorrhoids, and tissue adjacent a hole. A resilient ring-shaped body defines a compression channel, and one or more axially rigid elongated spikes extend from the body into the channel. The body defines a first axial segment surrounding the compression channel and a second axial segment surrounding the compression channel, with the spike being engaged only with the second axial segment. The first axial segment more tightly compresses the body structure than the second axial segment. | 03-15-2012 |
| 20120116295 | Topical Growth Factor Application Utilising a Microneedle Array - The present invention relates to improved topical administration of one or more growth factors for non-surgical, cosmetic use. In particular, a combination of one or more growth factors with a microneedle roller. Specifically, the invention resides in a kit for cosmetic use comprising: one or more growth factors, growth factor mimetics, and/or growth factor receptor agonists formulated for topical application; and means to perform wounding of skin, such as a microneedle array, wherein the wounding is targeted to at least the epidermis and/or dermis of the skin to release endogenous thrombin into dermal and/or epidermal tissue. | 05-10-2012 |
| 20120130306 | MICRONEEDLE DEVICE - Provided is a microneedle device where a coating agent has been applied to microneedles having a biodegradable resin. It has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength allows the microneedles to have excellent performance. Further, with regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate performance. Accordingly, when a microneedle device | 05-24-2012 |
| 20140066842 | MICRONEEDLE DEVICES AND METHODS - A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided. | 03-06-2014 |
| 20140066843 | MICRONEEDLE DEVICES AND METHODS - A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided. | 03-06-2014 |
| 20140094742 | DERMATOLOGICAL DRUG INJECTING DEVICE - The present invention relates to a dermatological drug injecting device, and more particularly, to a dermatological drug injecting device that can use a needle to treat wrinkles, dry skin, scars, freckles, hair loss, etc. on human skin, or to use ink to inscribe images or characters. To achieve said technical aims, a dermatological drug injecting device of the present invention installed on a skin maintenance apparatus comprises: a body portion installed on a fixing portion of a drug injecting device of the skin maintaining apparatus; a connecting driveshaft portion installed on the body portion and moved linearly; an actuating portion installed on the body portion and moved linearly by means of the connecting driveshaft portion; and a needle fixing portion installed on the actuating portion. | 04-03-2014 |
| 20140107566 | METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE - Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye. | 04-17-2014 |
| 20140180201 | MICROARRAY FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF USE - Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described. | 06-26-2014 |
| 20140188041 | METHOD - A method is provided for fabricating a microneedle or a microneedle array using a mould ( | 07-03-2014 |
| 20140200508 | Microneedles Comprising One Or More Cosmetic Ingredients - An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, and (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin. | 07-17-2014 |
| 20140200509 | Dissolvable Microneedles Comprising One Or More Encapsulated Cosmetic Ingredients - An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of dissolvable microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin, and (d) wherein said dissolvable microneedles are configured as a dissolvable exterior shell and said shell encapsulates one or more cosmetic agents. | 07-17-2014 |
| 20140236075 | HOLLOW NEEDLELIKE OBJECT AND METHOD FOR MANUFACTURING HOLLOW NEEDLELIKE OBJECT - According to one embodiment, a method for manufacturing a hollow needlelike object including a hollow part inside includes: a step of preparing a first needlelike-object base having a face comprising a groove forming at least a part of the hollow part; and a step of covering the face of the needlelike-object base with a covering member. | 08-21-2014 |
| 20140276378 | MICROSTRUCTURE ARRAY FOR DELIVERY OF ACTIVE AGENTS - Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features. | 09-18-2014 |
| 20140316333 | DISSOLVING SOLID SOLUTION PERFORATOR PATCH FOR MIGRAINE TREATMENT - A dissolving solid solution perforator (SSP) patch for oral cavity administration may include at least one perforator. The at least one perforator may contain a first drug and be configured to pierce an outside layer of an oral cavity for promptly delivering the first drug. The at least one perforator may penetrate an epithelium layer of the oral cavity and to deliver the antimigraine drug into blood vessels in a submucosa layer. | 10-23-2014 |
| 20140330198 | MICRONEEDLE DEVICE HAVING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID, METHODS OF MAKING AND USING THE SAME - A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine. | 11-06-2014 |
| 20140364801 | MICROPROTRUSION MEMBER RETAINER FOR IMPACT APPLICATOR - A retainer ( | 12-11-2014 |
| 20150018755 | SUBSTANCE DELIVERY DEVICE AND SUBSTANCE DELIVERY METHOD USING THE SAME - A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques. | 01-15-2015 |
| 20150025452 | Methods for Modulating Hair Growth Using Truncated Laminin-511 - Disclosed are methods for the use of a truncated, recombinant laminin-511 for modifying hair growth as well as delivery devices, kits and methods for topically administering truncated, recombinant laminin-511. Furthermore disclosed are delivery devices, kits and methods using modulators of full-length laminin-511 expression or function to decrease hair growth in areas of unwanted hair growth. | 01-22-2015 |
| 20150038897 | Low-Profile Microneedle Patch Applicator - A low-profile applicator, and a method of manufacturing and use thereof, for impacting microneedles against the stratum corneum of a person having a housing, a diaphragm member having the microneedles, a folding member having interlinking members that hinge-ably rotate with a force member, operatively attached thereto, between a resting position and an extended position. The folding member translates energy stored within the force member when release while retaining the force member in an energized state when in the resting position. | 02-05-2015 |
| 20150057604 | Puncture Device and Method for Manufacturing Same - A puncture device is a device for transferring an active ingredient into a body through a skin by piercing the skin with a microneedle. The puncture device comprises a tubular housing, a piston slidably arranged within the housing and having a main surface intersecting a sliding direction, and a nonlinear coil spring arranged within the housing and providing the piston with a biasing force. A plurality of microneedles are arranged on the main surface side. | 02-26-2015 |
| 20150057605 | Stable Glucagon Peptide Formulations - There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use. | 02-26-2015 |
| 20150065950 | Device for percutaneous delivery of therapeutic agents, and a method for its use - A device for percutaneous delivery of therapeutic agents includes a head, a wheel rotably mounted on the head, the wheel having an axis of rotation and an outer surface, a plurality of needles disposed upon the outer surface, each needle having a tip projecting away from the axis of rotation of the wheel, and a reservoir mounted on the body, the reservoir containing a fluid, the reservoir having an opening near to the wheel such that the fluid is disposed on the wheel through the opening. | 03-05-2015 |
| 20150094648 | MICRONEEDLE AND MICRONEEDLE ARRAY - The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently. | 04-02-2015 |
| 20150112250 | SOLUBLE MICRONEEDLE ARRAYS FOR BUCCAL DELIVERY OF VACCINES - A buccal microneedle patch may be provided for vaccination. The buccal microneedle patch may include at least one of microneedles. The at least one microneedles may be configured to contain a predetermined vaccine and to penetrate an outside layer of a buccal mucosa for promptly delivering the predetermined vaccine. | 04-23-2015 |
| 20150126923 | TIP-LOADED MICRONEEDLE ARRAYS FOR TRANSDERMAL INSERTION - A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion. | 05-07-2015 |
| 20150141910 | MICRONEEDLES FOR THERAPEUTIC AGENT DELIVERY WITH IMPROVED MECHANICAL PROPERTIES - Disclosed herein are systems and methods relating to microneedles, including a first element including an array of microprojections and a second element including a supportive substrate upon which the microprojections are formed perpendicular to the substrate surface. | 05-21-2015 |
| 20150290444 | APPLICATOR AND METHOD FOR APPLYING A MICRONEEDLE DEVICE TO SKIN - An applicator and method for applying a microneedle device to skin. The applicator can include a microneedle device and a housing configured to house the microneedle device. The housing can have a first surface configured to be positioned toward the skin. The applicator can include (i) an unactuated state in which the microneedle device is located within the housing and does not extend beyond the first surface of the housing, and (ii) an actuated state in which at least a portion of the microneedle device extends beyond the first surface of the housing. The applicator can further include a locking mechanism configured to lock the applicator in the actuated state. The method can include positioning the first surface of the housing of the applicator adjacent the skin; actuating the applicator to cause the applicator to change to the actuated state; and locking the applicator in the actuated state. | 10-15-2015 |
| 20150297878 | SOLVENT-CAST MICROPROTRUSION ARRAYS CONTAINING ACTIVE INGREDIENT - In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient. | 10-22-2015 |
| 20150335870 | PROTECTIVE RELEASE SHEET FOR MICRONEEDLE PATCH - Provided is a microneedle patch which is easily to be applied on a skin surface. | 11-26-2015 |
| 20150335872 | SWELLABLE ADHESIVE NEEDLES - This disclosure relates to swellable needles that include a proximal end portion and a swellable distal end portion. Upon exposure to a liquid, the needles are configured to undergo a shape change from a first configuration in which the width of the needle is tapered from the proximal end portion to the distal end portion to a second configuration in which the distal end portion is more swollen than the proximal end portion. The swellable needles can be double layer swellable needles or single material swellable needles. | 11-26-2015 |
| 20150352345 | MICRONEEDLE, MOULD FOR PRODUCING SAME, AND PRODUCTION METHOD FOR SAME - The present invention relates to a microneedle, to a mould for producing same, and to a production method for same. More specifically, the present invention concerns a microneedle for causing a skin-beautifying substance or drug to be absorbed via the skin, to a plastic mould for producing same, and to a production method for same. | 12-10-2015 |
| 20150374620 | Microneedle-Coating Composition and Microneedle Device - Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid. | 12-31-2015 |
| 20150374966 | METHOD FOR MAKING AN ARRAY OF MICRO-NEEDLES - There is described a method for making an array of micro-needles, comprising the steps of:
| 12-31-2015 |
| 20160001053 | DRUG-HOLDING MICRONEEDLE ARRAY AND MANUFACTURING METHOD THEREOF - The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. | 01-07-2016 |
| 20160015952 | A MICRONEEDLE PATCH - The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections | 01-21-2016 |
| 20160045720 | MICRONEEDLE DEVICE AND METHODS - Described are microneedle devices comprising an electron beam crosslinked or photocrosslinked polymer material, and methods of making and using them, such as for drug delivery or sampling biological fluids. | 02-18-2016 |
| 20160051467 | Stable Glucagon Peptide Formulations - There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use. | 02-25-2016 |
| 20160058992 | MICROSTRUCTURE ARRAY FOR DELIVERY OF ACTIVE AGENTS - Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features. | 03-03-2016 |
| 20160067176 | MICROSTRUCTURE ARRAY, METHODS OF MAKING, AND METHODS OF USE - A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent. | 03-10-2016 |
| 20160067468 | Device for Containment and Release of a Transdermal Drug Formulation - This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it. | 03-10-2016 |
| 20160067469 | METHOD FOR MANUFACTURING MICROSTRUCTURE USING CENTRIFUGAL FORCE AND MICROSTRUCTURE MANUFACTURED BY SAME - The present invention relates to a method for manufacturing a microstructure, the method comprising the steps of: (a) preparing a viscous composition on a lower substrate; and (b) applying centrifugal force to the viscous composition to induce extension of the viscous composition, thereby manufacturing a microstructure. According to the present invention, (i) a microstructure having a micro-unit diameter and sufficient effective length and hardness is provided; (ii) any process that may destroy activation of a drug or cosmetic component, such as high-temperature treatment, organic solvent treatment, etc., is avoided; (iii) loss resulting from contact and separation is reduced; (iv) the limitation of aspect ratio of the manufactured microstructure is overcome; (v) the limitation of yield resulting from flatness is overcome; and (vi) microstructures of various shapes can be manufactured. | 03-10-2016 |
| 20160074644 | MICROBLADE ARRAY IMPACT APPLICATOR - An applicator device ( | 03-17-2016 |
| 20160082240 | TRANSDERMAL PATCH MANUFACTURING METHOD AND TRANSDEMAL PATCH - A low cost transdermal patch comprises water soluble microneedles and has good performance. A transdermal patch comprises a microneedle sheet, which comprises a plurality of water soluble microneedles, moisture permeable sheet, wherethrough water vapor passes, and a reinforcing film. The reinforcing film is adhered, by an adhesive layer having an adhesive strength less than that of an adhesive layer, onto an outer surface of the moisture permeable sheet, which is the side opposite the skin opposing surface. The reinforcing film includes a water vapor barrier sheet, which blocks the passage of water vapor through at least a first area, and a removable portion around the water vapor barrier sheet. The removable portion is configures such that it can be separated from and peeled off the water vapor barrier sheet. | 03-24-2016 |
| 20160175211 | Method for the Removal of Tattoos and Skin Discolouration | 06-23-2016 |
| 20170232246 | NEEDLE ASSEMBLY FOR TRANSDERMAL ADMINISTRATION AND METHOD OF PRODUCING THE SAME | 08-17-2017 |
| 604047000 | With separate applicator for material or separate holder for material placed on applicator or in wound | 3 |
| 20090143724 | Microprojection Array Immunization Patch and Method - Skin patches ( | 06-04-2009 |
| 20090299274 | Method and Device for the Delivery of a Substance - An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin. | 12-03-2009 |
| 20140128802 | Chemical Applicator - The present invention relates to a device and method for a chemical applicator used applying chemicals to living organism's internal tissue, including the internal tissue of plants and animals, for organisms which reside on or in mediums such as land, air or water. The device of the present invention is predicated, in part, on the piercing elements being engageable with the chemical reservoir in order to effect the coating of the piercing elements with the chemical. Once coated, these piercing elements are then used to pierce the living organism's tissue such as plant tissue to deliver the chemical. | 05-08-2014 |
