| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 600328000 | Hemoglobin | 73 |
| 20080269580 | System for Non-Invasive Measurement of Bloold Glucose Concentration - A system and method for non-invasive measurement of glucose concentration in a live subject including a thermal emission spectroscopy (TES) device | 10-30-2008 |
| 20090048502 | Broadband illuminator for oximetry, hemoglobin, met-hemoglobin, carboxy-hemoglobin, and other blood component monitoring - An ischemia detection system in two or more somatic measures, collected simultaneously or near-simultaneously, are provided for direct or computational comparison, in which light from light source A ( | 02-19-2009 |
| 20090187087 | ANALYSIS OF METABOLIC GASES BY AN IMPLANTABLE CARDIAC DEVICE FOR THE ASSESSMENT OF CARDIAC OUTPUT - Analysis of metabolic gases by an implantable medical device allows the assessment of the status of a congestive heart failure patient by providing for the assessment of cardiac output. The present invention is directed to an implanted medical device configured to measure concentrations of metabolic gases in the blood to determine cardiac output of a patient. The device is also configured to measure changes in the cardiac output of a patient. The present invention is also directed to a method of measuring cardiac output by an implanted medical device. Further, the detection of changes in cardiac output utilizing an implanted medical device as disclosed herein is useful in a method of detecting exacerbation of congestive heart failure. The implanted medical device can also be used to pace a heart to modify cardiac output in a patient. | 07-23-2009 |
| 20090216098 | METHOD OF ASSESSING TISSUE VIABILITY USING NEAR-INFRARED SPECTROSCOPY - Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index <1) for prolonged periods (>6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index >1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful. | 08-27-2009 |
| 20090247853 | Non-Invasive Total Hemoglobin Measurement by Spectral Optical Coherence Tomography - Spectral Optical Coherence Tomography (“SOCT”) utilizes Optical Coherence Tomography (“OCT”) to depth-target two or more optical measurements within a blood vessel. OCT achieves depth resolution by the use of optical interferometry. As the path length of the reference arm of the interferometer is varied, the penetration depth at which maximum interference occurs (zero phase difference) in the sample is correspondingly increased. Depth resolution in the range of 10 μm to 100 μm enables measurements that may be made within more narrow spectral regions (in the range of 1 to 50 nm) in multiple regions of the visible and near infrared spectrum. In one embodiment the light source is configured for three spectral regions centered at 805 nm, 980 nm, and 1050 nm. By comparing the OCT signal at these different spectral positions, the absorption due to tissue and blood analytes may be measured. | 10-01-2009 |
| 20090281402 | Transabdominal examination, monitoring and imaging of tissue - An optical examination technique employs an optical system for in vivo, non-invasive examination of internal tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module is arranged for placement on the exterior of the abdomen or chest. The module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths targeted to examine a selected tissue region, such as an internal organ or an in utero fetus. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least one data set used for tissue examination. | 11-12-2009 |
| 20100081903 | FUNCTIONAL NEAR-INFRARED SPECTROSCOPY AS A MONITOR FOR DEPTH OF ANESTHESIA - Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia. | 04-01-2010 |
| 20100210931 | METHOD FOR PERFORMING QUALITATIVE AND QUANTITATIVE ANALYSIS OF WOUNDS USING SPATIALLY STRUCTURED ILLUMINATION - A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and/or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients. | 08-19-2010 |
| 20110004083 | Method and Device for Measuring Blood Flow Velocity - A method for measuring blood flow velocity comprises the steps of: placing a first and second blood vessel signal detectors on a body of a person to be measured in such a manner that the first and second blood vessel signal detectors are located a predetermined distance from each other; using the first and second blood vessel signal analyzers to record the blood signal at a predetermined time interval; setting an interval of time from the moment a specific blood vessel signal appears in a record of the first blood vessel signal analyzer to the moment the specific blood vessel signal appears in a record of the second blood vessel signal analyzer to be a predetermined time period; and dividing a value of the predetermined distance by a value of the predetermined time period can get a blood flow velocity. | 01-06-2011 |
| 20110118575 | METHOD AND APPARATUS FOR PRESSURE SORE DETECTION - The present invention pertains to a method and apparatus for pressure sore detection. A modulated optical signal based on a digital code sequence is transmitted to human tissue. A temporal transfer characteristic is derived from the modulated optical signal. Tissue characteristics is determined based on the temporal transfer characteristic. | 05-19-2011 |
| 20110190613 | HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS - Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display. | 08-04-2011 |
| 20120220844 | Regional Saturation Using Photoacoustic Technique - Methods and systems are provided for determining the oxygen saturation of a region in a patient's body using photoacoustic spectroscopy techniques. One embodiment includes determining an interrogation region, or a region in a patient to be monitored, and using a photoacoustic sensor to emit modulated light in the interrogation region. The modulated light may be absorbed by different absorbers, such as oxygenated hemoglobin and deoxygenated hemoglobin, in the interrogation region. The absorbed light results in an acoustic response which is detected by the photoacoustic sensor. Based on a non-pulsatile component of the acoustic response, the regional oxygen saturation at the interrogation region is calculated. | 08-30-2012 |
| 20120238848 | SYSTEM AND METHOD FOR PRACTICING SPECTROPHOTOMETRY USING LIGHT EMITTING NANOSTRUCTURE DEVICES - Embodiments of the present invention relate to a system and method for practicing spectrophotometry using light emitting nanostructures. Specifically, embodiments of the present invention include a physiologic sensor comprising a sensor body configured for placement adjacent pulsatile tissue of a patient, a first light emitting nanostructure device configured to emit light at a first wavelength through the pulsatile tissue, a second light emitting nanostructure device configured to emit light at a second wavelength through the pulsatile tissue, and a light detector configured to detect the light at the first wavelength and the light at the second wavelength after dispersion through the pulsatile tissue. | 09-20-2012 |
| 20120245443 | BIOLOGICAL LIGHT MEASUREMENT DEVICE - The mental state, such as mood or emotion, of an individual can be apprehended by a method using non-invasive biological light measurement technology. A biological light measurement device, which has an irradiation section, presents different tasks (at least a first task and a second task) to a subject, hemoglobin signals based on changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin in the subject are calculated from the strength of light detected by a detection section, and a relative value using the hemoglobin signal at a predetermined measurement channel with respect to the first task, and the hemoglobin signal at a different predetermined measurement channel with respect to the second task is calculated. | 09-27-2012 |
| 20120253157 | BLOOD INFORMATION MEASURING METHOD AND APPARATUS - In a special mode, a superficial wavelength set having plural types of narrow band light in a blue wavelength band of 400 to 500 nm is chosen. The plural types of narrow band light are successively applied to an internal body portion. A CCD captures images of the internal body portion under the narrow band light. A blood information calculation section calculates an oxygen saturation level of hemoglobin in a blood vessel based on an image signal. A comparison section compares the calculated oxygen saturation level with a predetermined threshold value. When the oxygen saturation level is less than the threshold value, a hypoxic region detection signal is outputted to a wavelength set switching section. The wavelength set switching section switches from the superficial wavelength set to a middle wavelength set and to a deep wavelength set, so the oxygen saturation levels at middle and deep depths are measured. | 10-04-2012 |
| 20120265041 | ELECTRONIC ENDOSCOPE SYSTEM AND METHOD FOR CONTROLLING THE SAME - A light source device of an electronic endoscope system has first and second semiconductor lasers. In a vascular observation mode, one of the semiconductor lasers is used in a full light state (100% rated output) while the other is used in a reduced light state (for example, 10% rated output). First and second images of an internal body portion are captured with a color imaging device under illumination of two patterns, respectively. Correlation operation of pixel values of three colors is performed between the two images. Noise components, caused by the first or second semiconductor lasers in the light reduced state, are removed from the first and second images. An oxygen saturation level of blood in a blood vessel is calculated using the first and second images with the noise components removed. | 10-18-2012 |
| 20120289801 | TISSUE IMAGING SYSTEM AND IN VIVO MONITORING METHOD - An in vivo monitoring method in a laparoscope system is provided. An object image is sequentially created with expression of a surface color of an object in a body cavity. A lock area (specific area) is determined within the object image, the lock area being movable by following motion of the object. A monitor image including a graph of oxygen saturation is generated according to a part image included in the object image and located in the lock area. The monitor image is displayed. Preferably, the oxygen saturation of the lock area is acquired according to two spectral data with respect to wavelengths of which an absorption coefficient is different between oxidized hemoglobin and reduced hemoglobin in data of the object image. The object is constituted by a blood vessel. | 11-15-2012 |
| 20120310062 | PHOTON DENSITY WAVE BASED DETERMINATION OF PHYSIOLOGICAL BLOOD PARAMETERS - A method for measuring a physiological parameter of blood in a patient is presented. The method includes emitting light from a modulated light source into tissue of the patient to generate a photon density wave in the tissue, detecting the photon density wave during pulsatile perturbation of the tissue, and processing an amplitude and phase of the photon density wave over the pulsatile perturbation to determine a value of the physiological parameter. | 12-06-2012 |
| 20120316410 | CANCELLATION OF LIGHT SHUNTING - There is provided a system and method for canceling shunted light. The method includes transmitting electromagnetic radiation at tissue of interest and generating a signal representative of detected electromagnetic radiation. A portion of the generated signal representing shunted light is canceled from the generated signal and the remaining portion of the generated signal is used to compute physiological parameters. | 12-13-2012 |
| 20130012793 | In-Vivo Optical Sensor - An apparatus for determining an optical property of a set of cells is described. The apparatus may include a light source for providing a light signal, a light-conditioning unit configured to condition the light signal, and a diffractive structure. The diffractive structure may be configured to receive the conditioned light signal and produce diffracted light having plasmon-resonance properties and an angular spectrum. The angular spectrum may correspond to the set of cells when the set of cells are within a threshold distance from the diffractive structure. The apparatus further includes a light-collecting unit for collecting the diffracted light. | 01-10-2013 |
| 20130012794 | RAPID MULTI-SPECTRAL IMAGING METHODS AND APPARATUS AND APPLICATIONS FOR CANCER DETECTION AND LOCALIZATION - Methods and apparatus for video rate or near video rate quantitative imaging of tissue physiological and morphological properties from visible/NIR light spectral images obtain rapid multi-spectral reflectance images by illuminating with a series of spectra containing multiple narrow wavelength bands. An iterative light-transport based inversion algorithm may be applied for correcting the intensity of the spectral images from the geometry/coupling effect as well as from the scattering amplitude distortions. The method can produce video rate absorption as well as scattering spectral images that can be further analyzed very rapidly, using matrix-based rapid inversion algorithms to produce more detailed quantitative images containing information relevant to tissue physiology and morphology. | 01-10-2013 |
| 20130090541 | Functional Near Infrared Spectroscopy Imaging System and Method - Disclosed is a functional NIRS imaging system including an elastomeric cap, a set of transmit optical fibers and a set of receive optical fibers terminating on the inside surface of the elastomeric cap. A pair of light sources combines to produce a collimated light beam at two wavelengths. An optical modulation system, converts the light beam into a plurality of probe light beams, modulates the plurality of probe light beams and directs each probe light beam into a transmit fiber. An optical detection system accepts scattered photons from subcutaneous tissue underneath the elastomeric cap as a plurality of collected light beams and converts them into a time series of electronic images, stores the electronic images into the memory and processes the electronic images using. The system displays the resulting image on a display as a hemoglobin oxygen saturation map. | 04-11-2013 |
| 20130102865 | SYSTEMS AND METHODS FOR FREQUENCY-DOMAIN PHOTOACOUSTIC PHASED ARRAY IMAGING - Systems and methods of frequency-domain photoacoustic imaging are provided utilizing an ultrasonic phased array probe and intensity modulated optical excitation with coding to improve signal-to-noise ratio. Embodiments employ frequency-domain photoacoustic imaging methodologies such as the photoacoustic radar, coupled with a multi-element ultrasonic sensor array to deliver spatially-resolved correlation images of photoacoustic sources, which may be employed to image optical heterogeneities within tissue-like scattering media. | 04-25-2013 |
| 20130109938 | METHOD AND APPARATUS FOR CALIBRATING AN ABSOLUTE OXYGEN SATURATION SENSOR | 05-02-2013 |
| 20130116521 | HOLDER AND LIGHT MEASUREMENT DEVICE EMPLOYING SAME - Provided is a holder which comprises at least two probe mount portions into which a light-transmitting probe for emitting light from the tip thereof or a light-receiving probe for receiving light through the tip thereof is inserted from above and is to be put on the head of a subject, the holder being characterized by further comprising: a linear backbone portion that extends in a first direction that is perpendicular to the above-described direction from above; and at least two linear branch portions that extend in a second direction that is perpendicular to the above-described direction from above and is different from the first direction, wherein the lower end portions of the probe mount portions protrude from the lower surface of the backbone portion or a branch portion and are tapered. | 05-09-2013 |
| 20130131477 | PULSE OXIMETRY SYSTEM - Systems and methods for estimating a saturation level of oxygen in hemoglobin (SpO2) are provided. In some aspects, a system includes a detector module configured to receive an oximeter output signal indicative of light absorption in a patient. The oximeter output signal alternates between infrared light components and red light components, and includes a first portion obtained at least partly during switching from at least one of the infrared components to at least one of the red components. The oximeter output signal also includes a second portion obtained at least partly during switching from at least one of the red components to at least one of the infrared components. The system also includes a processing module configured to estimate an SpO2 of the patient as a ratio between (i) a time derivative of the first portion and (ii) a time derivative of the second portion. | 05-23-2013 |
| 20130137949 | HYPERSPECTRAL IMAGING OF ANGIOGENESIS - The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging. | 05-30-2013 |
| 20130197331 | PHOTON DENSITY WAVE PULSE OXIMETRY AND PULSE HEMOMETRY - Present embodiments are directed to a system and method capable of modulating light to at least one modulation frequency selected based on at least one blood parameter of a medium being monitored to generate photon density waves in a medium, detecting relative amplitude changes and phase shifts in the photon density waves, and determining at least one blood parameter related to scattering particles in the medium based on the phase shifts. | 08-01-2013 |
| 20130211218 | BIOLOGICAL OPTICAL MEASUREMENT INSTRUMENT AND OPERATION METHOD THEREFOR - A biological optical measurement instrument includes a single temperature sensor that detects a radiation temperature from a plurality of light emitting elements that emit light of a predetermined wavelength, and an absorption coefficient correcting unit that corrects an absorption coefficient value of a notable substance inside the object on the basis of the radiation temperature detected by the temperature sensor, referring to data indicating a correspondence relationship between a temperature obtained in advance for each emitted light of the plurality of light emitting elements and an absorption coefficient value that varies according to the temperature. | 08-15-2013 |
| 20130225955 | DETERMINATION OF TISSUE OXYGENATION IN VIVO - A system and method for noninvasively determining the oxygenation of a tissue, for example, a muscle, in vivo uses optical methods to optically interrogate the tissue in both a visible wavelength range and a near infrared (NIR) wavelength range. The illuminating light is sculpted in intensity to approximately match the absorbance spectrum, for example, with the visible light having an intensity an order of magnitude greater than the light. Training data is obtained from healthy patients in both the visible and NIR ranges simultaneously and used to calculate muscle oxygenation. | 08-29-2013 |
| 20130274572 | PHYSIOLOGICAL PARAMETER TRACKING SYSTEM - A physiological parameter tracking system has a reference parameter calculator configured to provide a reference parameter responsive to a physiological signal input. A physiological measurement output is a physiological parameter derived from the physiological signal input during a favorable condition and an estimate of the physiological parameter according to the reference parameter during an unfavorable condition. | 10-17-2013 |
| 20130274573 | Systems And Methods For Measuring Mitochondrial Capacity - In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements. | 10-17-2013 |
| 20130310668 | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR OPTICAL MEASUREMENT OF BLOOD PARAMETERS - A system for optically measuring blood parameters including a light source and light transmitter for transmitting light to the blood, a light remitter for capturing remitted light, a spectrometer breaking the remitted light into its spectral components and a processor for comparing a morphologically distinct portion of the remitted light to a database of known morphologies. Each of the known morphologies corresponds to a measurement value at least one parameter, such as an analyte. Advantageously, the determined morphologies can uniquely correspond to two or more blood parameters, such as O | 11-21-2013 |
| 20130317331 | Monte Carlo and Iterative Methods for Determination of Tissue Oxygen Saturation - A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak. | 11-28-2013 |
| 20130338462 | System for Mitigating the Effects of Tissue Blood Volume Changes to Aid in Diagnosing Infiltration or Extravasation in Animalia Tissue - A system including a sensor and a device coupled to the sensor. The sensor is configured to detect in Animalia tissue (i) a first electromagnetic radiation extinction dominated by absorption of a first wavelength and (ii) a second electromagnetic radiation extinction dominated by scattering of a second wavelength. The device is configured to aid in diagnosing at least one of infiltration and extravasation in the Animalia tissue based on the first and second electromagnetic radiation extinctions detected by the sensor. | 12-19-2013 |
| 20140012112 | ENDOSCOPE SYSTEM, PROCESSOR DEVICE THEREOF, AND METHOD FOR CONTROLLING ENDOSCOPE SYSTEM - An electronic endoscope has normal and high-sensitivity image sensors. In a special mode for imaging an oxygen saturation level of blood, one of the normal and high-sensitivity image sensors is selected in accordance with a reflected light amount of special illumination light. When the normal image sensor is selected, the normal image sensor captures an image under irradiation with the special illumination light and outputs a second normal-sensor image. When an average pixel value of the second normal-sensor image is less than a first sensor selection threshold value, the use of the high-sensitivity image sensor is started. When the high-sensitivity image sensor is selected, the high-sensitivity image sensor captures an image under irradiation with the special illumination light and outputs a high-sensitivity-sensor image. When the average pixel value of the high-sensitivity-sensor image is more than a second sensor selection threshold value, the use of the high-sensitivity image sensor is stopped. | 01-09-2014 |
| 20140024905 | APPARATUS, SYSTEMS, AND METHODS FOR TISSUE OXIMETRY AND PERFUSION IMAGING - A compact perfusion scanner and method of characterizing tissue health status are disclosed that incorporate pressure sensing components in conjunction with the optical sensors to monitor the level of applied pressure on target tissue for precise skin/tissue blood perfusion measurements and oximetry. The systems and methods allow perfusion imaging and perfusion mapping (geometric and temporal), signal processing and pattern recognition, noise cancelling and data fusion of perfusion data, scanner position and pressure readings. | 01-23-2014 |
| 20140058232 | DILUTION GUIDED CORRECTION (DGC) METHOD AND APPARATUS FOR ADJUSTING NONINVASIVELY MEASURED TOTAL HEMOGLOBIN MEASUREMENTS AND METHOD FOR EVALUATING HYDRATION STATE OF A SUBJECT USING THE SAME - Methods and devices are provided for real time adjustment of noninvasively measured capillary hemoglobin concentration measures for a prediction of invasively measured hemoglobin concentration in large vessels and evaluating and modifying the state of interstitial hydration of an individual by the mVLT method. Implication of mVLT was refined by adding new diagnostic criteria and new variables, also expanding its noninvasive applicability. That opens application in the automated clinical decision support systems, semi-closed and closed loop infusion systems for optimisation of hydration, blood circulation and tissues perfusion, also optimizing blood transfusions. | 02-27-2014 |
| 20140058233 | CONCENTRATION-MEASUREMENT DEVICE AND CONCENTRATION-MEASUREMENT METHOD - A concentration measurement apparatus measures a temporal relative change amount (ΔcHb, ΔO | 02-27-2014 |
| 20140073891 | INSTRUMENT FOR MEASURING CARBON MONOXIDE POISONING OF HUMANS USING IN VIVO NIRS TECHNOLOGY - Spectral absorption based non-invasive procedure for determination of blood constituents utilizing in vivo NIRS (Near-Infrared Spectrum) technology, which is the measurement of the near-infrared absorption spectrum within a region of the living human body for the purpose of identifying tissue and blood components and their concentrations and more particularly to novel applications and methodology for determining the optical response, measurements and calculations relating to the concentrations of individual chromophores in the bloodstream and particularly to the level of CO chromophores in the tissues of an animal or human being. | 03-13-2014 |
| 20140081102 | FOCUSING ELECTROMAGNETIC RADIATION WITHIN A TURBID MEDIUM USING ULTRASONIC MODULATION - The present disclosure provides various systems and methods for focusing electromagnetic radiation (EMR) within a diffusion medium, such as a turbid medium. A diffusion medium is irradiated with EMR. The EMR may be modulated by an acoustical wave focused on a focus volume within the diffusion medium. The EMR may be modulated by a beat frequency or other function of multiple focused acoustical waves. The EMR may be modulated at a harmonic of a fundamental frequency of one or more acoustical waves. A filter may filter the emerging EMR to remove all but specifically modulated EMR scattered from the focus volume. The modulated EMR may be focused and/or used for various purposes, including imaging. In some embodiments, the modulated EMR may be reflected and/or amplified by a phase conjugating mirror. Furthermore, in some embodiments, acoustical phase conjugation may be used to focus an acoustical wave on a focus volume. | 03-20-2014 |
| 20140128697 | METHODS FOR DETECTION OF RESPIRATORY EFFORT AND SLEEP APNEA MONITORING DEVICES - A sleep apnea diagnostic system includes a housing that is configured to be attached to near the nose of a patient's face to sense physiological information of a patient. The housing includes sensors to sense the physiological information. The physiological information may be, for example, air flow through the nose or the mouth or both. The physiological information further may be, for example, blood volume. The sleep apnea diagnostic system includes at least one processor in the housing or external to the housing or both to analyze the physiological information to determine whether the patient has experienced irregular or abnormal respiratory activity and to detect respiratory effort. The analysis may be real time or delayed. | 05-08-2014 |
| 20140155716 | Light Wavelength Selection for Avoidance of Surgical Dyes - A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers. | 06-05-2014 |
| 20140275891 | OPTICAL TOMOGRAPHY SENSOR AND RELATED APPARATUS AND METHODS - Optical sensors, systems, and methods are described, which may be used to provide or analyze information about a subject. The optical sensor may be placed in proximity to the subject and may include optical sources and optical detectors. The optical sources may irradiate the subject with optical signals and the optical detectors can detect signals from the subject. Analysis of the detected signals can yield information about the subject. | 09-18-2014 |
| 20140303464 | FUNCTIONAL NEAR-INFRARED SPECTROSCOPY AS A MONITOR FOR DEPTH OF ANESTHESIA - Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia. | 10-09-2014 |
| 20140343384 | FIBER OPTIC FLOW AND OXYGENATION MONITORIONG USING DIFFUSE CORRELATION AND REFLECTANCE - Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome. | 11-20-2014 |
| 20140350366 | PHOTOELECTRIC CONVERSION DEVICE AND MANUFACTURING METHOD THEREOF - According to one embodiment, a photoelectric conversion device including a substrate having opaque interconnection layers, an insulating film formed on the substrate, and having a plurality of openings, light-emitting elements formed of the openings, each light-emitting element having an upper electrode layer, and light-receiving elements formed of the openings, each light-receiving element having an upper electrode layer, wherein a semiconductor material is different in the light-emitting element and the light-receiving element, the upper electrode layer both of the light-emitting element and the light-receiving element are formed as common electrodes, and each interconnection layer is formed on a region outside a region specified by the opening. | 11-27-2014 |
| 20140371557 | BIOLOGICAL SIGNAL MEASURING SYSTEM AND BIOLOGICAL SIGNAL MEASURING APPARATUS - A biological signal measuring system includes: a light emitter emitting light beams having different N kinds of wavelengths, where N is an integer of four or more; a light receiver outputting N kinds of signals respectively in accordance with received light intensities of the N kinds of light beams that have been passed through or reflected from a living tissue; a first calculating section acquiring N kinds of light attenuations based on the N kinds of signals; a second calculating section acquiring (N−1) kinds of blood-derived light attenuations based on two light attenuations related to (N−1) kinds of combinations selected from the N kinds of light attenuations; a third calculating section identifying concentrations of (N−1) kinds of in-blood substances based on the (N−1) kinds of blood-derived light attenuations; and an outputting section outputting the identified concentrations. | 12-18-2014 |
| 20140378796 | SYSTEM AND METHOD FOR NEEDLE NAVITATION USING PA EFFECT IN US IMAGING - The present invention provides a monitoring system, which comprises a novel needle, and an optical signal generating device, wherein at least one optical signal output of the optical signal generating device is coupled to the optical core of the needle, and it further comprises an ultrasound (US) transducer,and a processor adapted to direct the US transducer to transmit an US signal into a region of a subject in which the needle is moving and receive an US signal reflected in the region in response to the transmitted US signal in a US measurement sub-cycle of a measurement cycle, and to direct the optical signal providing device to transmit an optical signal having a unique wavelength from the dome of the needle into an area of the region and direct the US transducer to receive a photo-acoustic (PA) signal induced in the area in response to the optical signal in each of at least one PA measurement sub-cycle of the measurement cycle, and reconstruct an US image from the US signal received in the US measurement sub-cycle. | 12-25-2014 |
| 20150018654 | METHOD AND APPARATUS FOR MONITORING A SUBJECT FOR FRACTIONAL BLOOD OXYGEN SATURATION - What is disclosed is a system and method for monitoring a subject of interest for fractional blood oxygen saturation using an apparatus that can be comfortably worn by the subject around an area of exposed skin where a photoplethysmographic (PPG) signal can be registered. In one embodiment, the apparatus is a reflective or transmissive wrist-worn device with emitter/detector pairs fixed to an inner side of a band with at least three illuminators, each emitting source light at a different wavelength band. Each photodetector comprises sensors that are sensitive to a wavelength band of a respective illuminator. Each photodetector measures an intensity of sensed light emitted by a respective illuminator. The signal obtained by the sensors comprises a continuous PPG signal. The continuous PPG signal analyzed for fractional blood oxygen saturation levels and communicated to a remote device. Various embodiments are disclosed. | 01-15-2015 |
| 20150025343 | SYSTEM AND METHOD FOR OPTICAL DETECTION OF SKIN DISEASE - An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease. | 01-22-2015 |
| 20150025344 | METHOD FOR SPECTROPHOTOMETRIC BLOOD OXYGENATION MONITORING - An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting. | 01-22-2015 |
| 20150038812 | FUNCTIONAL NEAR INFRARED SPECTROCOPY BASED BRAIN COMPUTER INTERFACE - Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over computing environments using fNIR brain computer interfaces. Further still, a scale for brain interface index for oxygenation of a portion of the brain is provided herein. | 02-05-2015 |
| 20150038813 | PHOTOACOUSTIC DIAGNOSIS DEVICE, METHOD, PROGRAM AND RECORDING MEDIUM - A photoacoustic diagnosis device that diagnoses a state of a skin of a human body, includes a pulsed light source, an electric signal converter, a blood distribution obtaining section, and a diagnosis section. The pulsed light source generates a pulsed light. The electric signal converter receives a photoacoustic wave generated at the skin by the pulsed light and converts the photoacoustic wave into an electric signal. The blood distribution obtaining section obtains distribution of blood in the skin based on the electric signal. The diagnosis section diagnoses a state of the skin based on a result obtained by the blood distribution obtaining section. | 02-05-2015 |
| 20150051464 | CONCENTRATION MEASUREMENT DEVICE AND CONCENTRATION MEASUREMENT METHOD - A concentration measurement apparatus includes a probe, having a light incidence section making measurement light incident on the head and a light detection section detecting the measurement light that has propagated through the interior of the head, a CPU determining a temporal relative change amount of oxygenated hemoglobin concentration and performing a filtering process of removing frequency components less than a predetermined frequency from frequency components contained in the relative change amount, and a display section displaying first time series data indicating the filtering-processed relative change amount. The CPU judges whether or not chest compression is being performed. If chest compression is not performed for a predetermined time, the display section switches from displaying the first time series data to displaying second time series data indicating the relative change amount that contains frequency components less than the predetermined frequency. | 02-19-2015 |
| 20150087939 | CANCELLATION OF LIGHT SHUNTING - There is provided a system and method for canceling shunted light. The method includes transmitting electromagnetic radiation at tissue of interest and generating a signal representative of detected electromagnetic radiation. A portion of the generated signal representing shunted light is canceled from the generated signal and the remaining portion of the generated signal is used to compute physiological parameters. | 03-26-2015 |
| 20150119665 | SELF-REFERENCING OPTICAL MEASUREMENT FOR BREAST CANCER DETECTION - Optical data is obtained from a pair of breasts, employing a simultaneous bilateral referencing protocol, and is subsequently analyzed employing a self-referencing data analysis method. Optical measurements can be performed on both breasts simultaneously under various protocols, including resting-state measures and evoked responses. Sensing hardware and data collection protocols are economical and can be implemented without patient discomfort. The natural variance inherently associated with optical measures of the breast is reduced by: imposition of substantially symmetric boundary conditions; collection of simultaneous bilateral dynamic measures; referencing measurement data of one breast to measurement data from another. | 04-30-2015 |
| 20150148635 | Rate-Estimation Sensor And Method For Cell Phones, Smart Watches, Occupancy Sensors, And Wearables - An improved sensor ( | 05-28-2015 |
| 20150148636 | Ambient Light Method For Cell Phones, Smart Watches, Occupancy Sensors, And Wearables - An improved sensor ( | 05-28-2015 |
| 20150297124 | OPTICAL BIOMETRIC DEVICE - An optical biometric device includes a light sending/receiving unit having light sending probes placed on the head of a subject and light receiving probes placed on the head; a control unit for sending and receiving light to obtain M pieces of information about the amount of light received in M measurement portions; an operation unit for acquiring M pieces of measurement data based on the M pieces of information a display control unit for displaying N pieces of measurement data selected from among M pieces of measurement data on a display screen; and a process unit for processing at least one piece of measurement data selected from among the N measurement data. On the display screen, a measurement data image is selected so that measurement data to be processed in the process unit is determined, and the processed measurement data is displayed. | 10-22-2015 |
| 20150297125 | OXIMETRY SENSOR ASSEMBLY AND METHODOLOGY FOR SENSING BLOOD OXYGEN CONCENTRATION - A sensor in accordance with the present disclosure is configured to measure a subject's blood oxygen concentration. In illustrative embodiments, the sensor may be coupled to a seat for use in a seating environment or any other suitable environment. In illustrative embodiments, the sensor is an oximetry sensor assembly being provided in a vehicle seat or other support in proximity and contact with an occupant's body. | 10-22-2015 |
| 20150297126 | BIOLOGICAL STATE ASSESSMENT DEVICE AND PROGRAM THEREFOR - Provided is a biological state assessment device for assessing biological state, such as mood or emotions, using non-invasive biophotonic measurement technology. The present invention includes a light irradiation unit ( | 10-22-2015 |
| 20150313518 | IMAGE BASED OXYGEN SATURATION MEASURING DEVICE AND METHOD THEREOF - The present invention is an image based oxygen saturation measuring device and method thereof. The method comprises steps of providing a plurality of red lights and a plurality of infrared lights arranged uniformly in an interlocked fashion and turned on alternatively; controlling the plurality of red lights and infrared lights to irradiate onto a selected skin area of a testee to have a red light turn-on period and an infrared light turn-on period; receiving a reflected version of the plurality of red lights and infrared lights from the selected skin area, respectively; and analyzing one reflected red light and one infrared light to acquire an oxygen saturation index for each of the coordination points. By means of the present invention, the measurement of oxygen saturation may be much exempted from effects brought from exterior interference and poor blood circulation, and may achieve a large measurement area in a single time. | 11-05-2015 |
| 20150351696 | BIOLOGICAL OPTICAL MEASUREMENT DEVICE AND SIGNAL SEPARATION METHOD FOR SAME - The present invention comprises an analysis unit for applying a plurality of candidate delay times to either data with a short SD distance or data with a long SD distance acquired in advance and calculating a separation degree indicating the degree of separation of the skin blood flow signal after separation using the TDD-ICA method for each candidate delay time; a delay time determination unit for determining the optimal delay time according to the separation degree; and a display data generation unit for generating display data to display a waveform before the separation and a waveform of the cerebral blood flow signal as well as a waveform of the skin blood flow signal after the separation on a display unit so as to be compared with each other when displaying the result of the separation using the determined delay time. | 12-10-2015 |
| 20160022184 | TECHNIQUE FOR REMANUFACTURING A MEDICAL SENSOR - Remanufactured medical sensors and methods for remanufacturing used medical sensors are provided. Such a remanufactured sensor may include certain components from a used medical sensor and certain new components. For example, a remanufactured regional oximetry sensor may include a padding layer, an emitter and a pair of detectors, a flexible circuit coupled to the emitter and detectors, and a patient-contacting adhesive layer. The flexible circuit, the emitter, the first detector, the second detector, or any combination thereof, are from a used medical sensor, and the padding layer, the patient-contacting adhesive layer, or a combination thereof, are new. | 01-28-2016 |
| 20160058274 | IMAGE CAPTURING SYSTEM AND ELECTRONIC ENDOSCOPE SYSTEM - An image capturing system, comprising: a light source device that emits illumination light containing wavelength regions; an image pickup device having an RGB filter; and an image processing unit to calculate a first index representing a molar concentration ratio of a first biological substance and a second biological substance contained in the living tissue, wherein the wavelength regions comprise: a first wavelength region corresponding to a B filter; and a second wavelength region corresponding to a G filter, wherein: in the first wavelength region, a value of image data B varies depending on the molar concentration ratio; the second wavelength region contains a plurality of isosbestic points of the living tissue, and, in the second wavelength region, a value of image data G takes a constant value without depending on the molar concentration ratio. | 03-03-2016 |
| 20160089067 | NEAR INFRARED OXYGEN CONCENTRATION SENSOR FOR PALPATION - A near-infrared oxygen concentration sensor for palpation | 03-31-2016 |
| 20160100781 | Oximeter Probe with Light Wavelengths to Avoid Surgical Dyes - A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers. | 04-14-2016 |
| 20160166194 | SYSTEM AND METHOD FOR OPTICAL DETECTION OF SKIN DISEASE | 06-16-2016 |
| 20160174843 | Multispectral Measurement for Improved Biological Signal Acquisition | 06-23-2016 |
| 20180020959 | CONCENTRATION-MEASUREMENT DEVICE AND CONCENTRATION-MEASUREMENT METHOD | 01-25-2018 |
| 20190142316 | Systems And Methods For Measuring Neonatal Cerebral Oxygenation | 05-16-2019 |
| 20220133187 | DEVICE AND METHOD FOR MEASURING BLOOD COMPONENTS - The present disclosure is directed to a method and device to determine a hemoglobin value of a mammal. The device includes a plurality of light emitting diodes, one or more sensors and a processor. | 05-05-2022 |
