Entries |
Document | Title | Date |
20080200781 | Glucose Sensor - A system for the non-invasive measurement of glucose concentration in a live subject is disclosed. The system exploits the metabolic heat conformation method, and comprises temperature sensing means for measuring the body heat in respect of the subject and means for measuring the concentration of haemoglobin and oxygenated haemoglobin in the blood of the subject. The system further comprises irradiating means for irradiating a portion of the live subject, a detector for collecting the measuring beam reflected by the live subject, means for determining from the reflected measuring beam, the blood flow velocity in respect of the live subject, and means for determining glucose concentration in the live subject as a function of the body heat, the haemoglobin and oxygenated haemoglobin concentrations and the blood flow velocity. | 08-21-2008 |
20080200782 | Health Monitoring Device, Device Modules and Method - The present invention relates to a health monitoring device for measuring blood or tissue indicators and a strip cassette suitable for use in connection with the device. The device comprises a body ( | 08-21-2008 |
20080214912 | Blood Glucose Monitoring System And Method - An optrode for insertion into a blood vessel can include at least one fiber optic, a sheath enclosing at least part of the fiber optic and sensor material in optical communication with one end of the fiber optic. The sensor material is operative for diffracting electromagnetic waves received from the fiber optic and is responsive to changes in an amount of glucose in contact therewith for changing a diffraction of the electromagnetic waves as a function thereof. A membrane covering a distal end of the sheath passes to the sensor material glucose from blood in contact with the side of the membrane opposite the sensor material. Electromagnetic waves input into the fiber optic cable are diffracted by the sensor material. A concentration of glucose in the blood can be estimated from the amount of diffraction of the electromagnetic waves. A signal can be output related to the estimated glucose concentration. | 09-04-2008 |
20080221415 | Systems and methods for measuring and improving blood chemistry - Measurement systems provide a determination of relative concentrations of biological analytes based on transmission or reflection of near-infrared radiation by an in vivo specimen. Concentration and concentrations ratios associated with (ω-3, ω-6, and ω-9 fatty acids, lipids, glycosylated proteins, blood glucose, and cholesterol can be determined, and based on the determination an indication of subject health can be provided, or a dietary recommendation can be made. In one example, ratio of a concentration of ω-3 fatty acids to a combined concentration of ω-6 and ω-9 concentrations is determined. Dietary supplements can be recommended or ordered from a supplier based on the concentrations and concentration ratios. | 09-11-2008 |
20080228050 | Noninvasive in vivo measuring system and noninvasive in vivo measuring method by correcting influence of Hemoglobin - A noninvasive in vivo measuring system and a noninvasive in vivo measuring method are provided. In the noninvasive in vivo measuring system, a Raman-fluorescence measuring unit measures blood sugar concentration, which is measured using Raman spectra before and after applying a pressure on a finger, and outputs a final blood sugar level by correcting the blood sugar concentration measurement according to a Hemoglobin (Hb) concentration measured by an Hb measuring unit. | 09-18-2008 |
20080228051 | ANALYTE MEASURING DEVICE - An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device. | 09-18-2008 |
20080269575 | Method and Apparatus for Monitoring Bodily Analytes - The present invention relates mainly to a method and apparatus for monitoring bodily analytes, such as glucose, by use of an analyzer ( | 10-30-2008 |
20080275318 | BIOSENSORS FOR MEASURING ANALYTES IN THE INTERSTITIAL FLUID - The invention relates to methods and devices for measuring blood glucose levels in a subject, where the methods and devices are designed for exposing a sensing mechanism to interstitial fluid in the subject. | 11-06-2008 |
20080275319 | Non-Invasive System and Method for Measuring Skin Hydration of a Subject - A non-invasive system and method for measuring skin hydration of a subject comprising a thermistor ( | 11-06-2008 |
20080281171 | ANALYTE MONITORING SYSTEM AND METHODS - Methods and systems for providing data communication in medical systems are disclosed. | 11-13-2008 |
20080319287 | Implantable Power Sources and Sensors - A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus ( | 12-25-2008 |
20090018416 | Analyte Concentration Measurement Device - A method for measuring concentration of an analyte in body fluid comprises acquiring a body fluid sample, emitting light into the body fluid sample, and detecting emitted light intensity on a plurality of optical paths through the body fluid sample. A plurality of optical filters are arranged in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by an analyte and water and a second optical filter with light absorption to water alone. Light intensity passed through the first optical filter and passed through the second optical filter is measured and analyte concentration is determined based on a ratio of intensities detected at a detector in an optical path intersected by the first optical filter and detected at a detector in an optical path intersected by the second optical filter. | 01-15-2009 |
20090018417 | APPARATUS MONITORING SIGNAL IN SITU - For repeatedly measuring signals from a fixed position of a tissue to monitor the blood composition, we use one or more elastic membranes at upper and lower parts of the extruded tissue together with a cone-shaped guide. This will constrain the tissue in the fixed position when a signal guide is used for measuring signals from the fixed position of the tissue repeatedly. The signals can be from an aggregate of the designated composition with the other ingredients of the blood. | 01-15-2009 |
20090030295 | INSTRUMENT FOR MEASURING CONCENTRATION OF LIVING BODY INGREDIENT - A biological constituent concentration measuring device that can measure a biological constituent concentration highly accurately using a radiation that has come from an eardrum is provided. | 01-29-2009 |
20090036760 | METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 02-05-2009 |
20090048501 | Glucose measuring device integrated into a holster for a personal area network device - A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump. | 02-19-2009 |
20090054746 | Device for channeling fluid and methods of use - Method and apparatus for channeling fluid away from an insertion site having a channel guiding the fluid flow from the insertion site, and a channeling compartment containing absorbent material to wick the fluid such as blood away from the insertion site is provided. | 02-26-2009 |
20090054747 | Method and system for providing analyte sensor tester isolation - Method and apparatus for providing electrical isolation between devices in batch testing process during manufacturing procedure is provided. | 02-26-2009 |
20090054748 | Method and system for providing continuous calibration of implantable analyte sensors - Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed. | 02-26-2009 |
20090054749 | Method and System for Providing Data Transmission in a Data Management System - Methods and apparatuses for providing a data transmission unit antenna for wireless data transmission in a data monitoring and management system are provided. | 02-26-2009 |
20090054750 | Method and System for Providing Integrated Analyte Monitoring and Infusion System Therapy Management - Method and system for providing diabetes management and insulin therapy based on substantially real time glucose monitoring system is provided. | 02-26-2009 |
20090062632 | Non-Invasive System and Method for Measuring an Analyte in the Body - A system for determining an analyte concentration in a fluid sample (e.g., glucose) comprises a light source, a detector, and a central processing unit. The detector is adapted to receive spectral information corresponding to light returned from the fluid sample being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid. The algorithm is adapted to convert the received spectral information into the analyte concentration in body fluid. Spectral information is delivered from the central processing unit to the light source and used to vary the intensity and timing of the light to improve the accuracy of conversion into analyte concentration. | 03-05-2009 |
20090069651 | MONITORING METHOD AND/OR APPARATUS - A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost. | 03-12-2009 |
20090088614 | On-body medical device securement - Devices and methods for maintaining a medical device on-body are provided. Embodiments include medical device securement systems having first and second on-body securement elements. Also provided are systems and kits for use maintaining a medical device on-body. | 04-02-2009 |
20090088615 | Indwelling Fiber Optic Probe for Blood Glucose Measurements - An indwelling fiber optic probe can be used to make in vivo blood glucose measurements through a central venous catheter. The fiber optic probe can operate in the near-infrared spectral region. The optical measurement can be backscattering, transmission, or a combination of both, depending on the optical configuration. | 04-02-2009 |
20090131772 | MEDICAL DEVICE - A medical device ( | 05-21-2009 |
20090156915 | Glucose Monitor and Method of Use Thereof - An apparatus for monitoring glucose comprising a processor, an indicating mechanism and sensors that are disposed proximate the skin of a person when the skin is in contact with a motor vehicle operational component such as the steering wheel. The apparatus for monitoring glucose measures the driver's glucose concentration via optical coherence tomography or other non-invasive technique, analyzes the driver's glucose concentration via the processor and displays the driver's glucose concentration via the indicator, or alternately sends an alarm signal. The method for monitoring glucose further comprises programming the processor with a range of glucose concentrations, comparing the driver's glucose concentration with the range and signaling an alert if the driver's glucose concentration is outside the range. | 06-18-2009 |
20090209834 | System and Method for In Vivo Measurement of Biological Parameters - A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof. | 08-20-2009 |
20090221886 | METHOD AND APPARATUS FOR MEASURING ANALYTES - A method for measuring the concentration of various analytes in the blood of a part of a subject is provided An invasive or non-invasive sample of blood may be used for this determination Also provided is a device for measuring the concentration of a compound in the blood of a subject. The device comprises a source of electromagnetic radiation, a holder, a detector and a processing system. | 09-03-2009 |
20090247842 | Interferometric Measuring Instrument for Taking Optical Measurements on Skin Structures - An interferometric measuring instrument for taking optical measurements on skin structures, having a beam splitter for splitting an input beam, emitted by a light source, into an object beam and a reference beam; having an object branch via which the object beam is directed to the skin, and the object beam, scattered back from the skin structures, is returned; having a reference branch via which the reference beam is directed to a reference and returned from it; and having a detector device for picking up the recombined and interfering radiation of the back-scatted object beam and of the returned reference beam and for evaluating the intensity modulation obtained due to the interference. The following measures contribute significantly to a reliable and rapid optical measurement, e.g., of the blood-sugar concentration: In order to scatter back a portion of the object beam directed into the skin, an implant having a front side facing the incident object beam and a back side facing away from it is introduced into the skin, the implant having a refractive index different from the surrounding skin substance. | 10-01-2009 |
20090247843 | Method and System for Non-Invasive Blood Glucose Detection Utilizing Spectral Data of One or More Components Other Than Glucose - A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device. | 10-01-2009 |
20090253970 | SYSTEM FOR OPTIMIZING A PATIENT'S INSULIN DOSAGE REGIMEN - A system for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range. | 10-08-2009 |
20090264719 | SENSOR FOR PERCUTANEOUS INTRAVASCULAR DEPLOYMENT WITHOUT AN INDWELLING CANNULA - The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue. | 10-22-2009 |
20090270700 | NON-INVASIVE GLUCOSE SENSOR - Apparatus and method for sensing HO activity, and in particular blood glucose level based on an analyte level determination, the analyte being carboxyhemoglobin. In a preferred embodiment, HO activity and/or blood glucose level are extrapolated from Hb-CO level by determining an intermediate CO level. The apparatus and method are preferably non invasive. | 10-29-2009 |
20090270701 | DEVICE FOR MEASURING CONCENTRATION OF CONSTITUENT IN BLOOD ANDMEASURING METHOD - A device for measuring concentration of a constituent in blood includes: an irradiation unit for irradiating light toward a living body, the light having a wavelength disposed in a light absorption band of the constituent in the blood; a light receiving unit for receiving light, which is reflected in the living body or transmitted through the living body; and a concentration measurement unit for measuring the concentration of the constituent in the blood based on variation of light intensity of light received by the light receiving unit, the variation attributed to a pulse wave of the living body. | 10-29-2009 |
20090275814 | SYSTEM AND METHOD FOR MEASURING CONSTITUENT CONCENTRATION - A system and method for measuring concentration of a constituent of a specimen are provided. The system includes an oscillator for outputting, towards the specimen, electromagnetic waves having respective different frequencies between 5 GHz and 300 GHz; a detector for detecting the electromagnetic waves that are reflected from the specimen; and a processor measuring at least one of reflection coefficient and complex permittivity of the electromagnetic waves detected and calculating the concentration of the constituent of the specimen based upon at least one of the reflection coefficient measured and the complex permittivity measured. | 11-05-2009 |
20090292186 | Method and System for Non-Invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting for the effect of temperature on various system components such as resistors, and (5) accounting for dark current in a light detector by performing a calibration. | 11-26-2009 |
20090312615 | Device for Determining the Glucose Level in Body Tissue - The apparatus for the non-invasive glucose detection comprises an electrical detection device ( | 12-17-2009 |
20100016689 | METHOD FOR NONINVASIVE MEASUREMENT OF GLUCOSE AND APPARATUS FOR NONINVASIVE MEASUREMENT OF GLUCOSE - A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals. | 01-21-2010 |
20100022860 | NON-INVASIVE METHODS OF USING SPECTRAL INFORMATION IN DETERMINING ANALYTE CONCENTRATIONS - A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal. | 01-28-2010 |
20100030040 | MULTI-STREAM DATA COLLECTION SYSTEM FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS - The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry. | 02-04-2010 |
20100036215 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 02-11-2010 |
20100036216 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 02-11-2010 |
20100041969 | MEASURING DEVICE AND METHOD FOR OPTICALLY DETERMINING THE CONCENTRATION OF BLOOD SUGAR AND/OR LACTATE IN BIOLOGICAL SYSTEMS - The invention relates to a measuring device for optically determining the concentration of blood sugar and/or lactate in biological systems, comprising at least one IR radiation source, that radiates IR light on a volume that is to examined, and at least one measuring detector that detects light coming from the volume that is to be examined in order to determine the concentration of blood sugar and/or lactate, also by laymen in a simple manner and anywhere. According to the invention, the IR light radiated on the volume that is to be examined is supplied, prior to entry into the volume, to a reference detector. | 02-18-2010 |
20100063370 | Noise tolerant measurement - The invention relates to statistical methods for fitting a mathematical model of the interaction of signals, such as optical signals, with tissue to detected signals or data related to the interaction. In particular it relates to statistical methods for fitting a mathematical model of the interaction of optical signals with tissue to actual signals, such as interferometric signals related to data optical scattering in tissue and their relationship to glucose concentration. It also relates to statistical methods for fitting a mathematical model of the interaction of optical signals with tissue to data such as the spectral distribution values of optical signals absorbed or scattered by tissue and their relationship to glucose concentration. The invention provides a practical non-invasive glucose measurement method and system. The invention also provides a measurement method and system that performs well in low signal-to-noise environments. | 03-11-2010 |
20100099960 | Device and method for measuring a property of living tissue - A device for measuring the glucose level in living tissue has electrodes ( | 04-22-2010 |
20100113900 | Multispot Monitoring for Use in Optical Coherence Tomography - Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis. | 05-06-2010 |
20100121163 | Optical Microneedle-Based Spectrometer - Optical microneedles are adapted for near-infrared or mid-infrared in vivo spectroscopic sensing; and provide a MEMS-based spectrometer for continuous lactate and glucose monitoring by means of a near-infrared or mid-infrared optical microneedle array in a transdermal patch. | 05-13-2010 |
20100130839 | IMPLANTABLE DEVICES AND METHOD FOR DETERMINING A CONCENTRATION OF A SUBSTANCE AND/OR MOLECULE IN BLOOD OR TISSUE OF A PATIENT - In a medical lead having a sensor, an implantable device connectable to such a medical lead and a method for determining the concentration of a substance and/or molecule in blood or tissue of a patient, in particular for determining the concentration of substances and or molecules such as oxygen, carbon dioxide, molecules representative of a PH value, glucose, urea, ammonia, lactose, hormones and insulin, photoluminescent molecules embedded in a carrier, in which the substance and/or molecule to be analyzed diffuse, are excited to emit light by light emitted by a light source of the sensor. The determination of the concentration of the substance and/or molecule is based on the characteristics of the light emitted by the photoluminescent molecules. | 05-27-2010 |
20100160749 | IMPLANTABLE OPTICAL GLUCOSE SENSING - Apparatus is provided, including a support configured to be implanted within a body of a subject and a sampling region coupled to the support. The apparatus is configured to passively allow passage through the sampling region of at least a portion of fluid from the subject. The apparatus also comprises an optical measuring device in optical communication with the sampling region. The optical measuring device comprises at least one light source configured to transmit light through at least a portion of the fluid, and at least one sensor configured to measure a parameter of the fluid by detecting light passing through the fluid. Other embodiments are also described. | 06-24-2010 |
20100174159 | NON-INVASIVE BODY INFORMATION MEASUREMENT APPARATUS - A non-invasive body information measurement apparatus, in which a blood glucose level is corrected using a blood glucose level measured with an invasive blood glucose measurement apparatus, wherein in a calibration period, measurement of body information is performed at a plurality of luminous energy levels, a plurality of estimated blood glucose levels are calculated from a plurality of characteristic quantities calculated at the various luminous energy levels and from blood glucose levels measured with an invasive blood glucose measurement apparatus, and at the end of the calibration period, the blood glucose levels measured with the invasive blood glucose measurement apparatus are compared with a plurality of estimated blood glucose levels, and in a normal measurement period a light source is controlled so that measurement is performed at a luminous energy level corresponding to the estimated blood glucose level that satisfies the targeted accuracy. | 07-08-2010 |
20100222657 | Method for glucose monitoring using fluorescence quenching - This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable. | 09-02-2010 |
20100274110 | OPTICAL DETERMINATION OF PH AND GLUCOSE - Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose. | 10-28-2010 |
20100298673 | METHOD FOR THE GLUCOSE CONCENTRATION IN PULSATIONAL BLOOD - Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps: determination of a value for the glucose concentration for a first measurement cycle, and repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and/or scattering power of the blood for at least two incident MR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and/or scattering power, continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two MR wavelengths is selected from the wavelength range 1560-1630 nm, and the second of the at least two MR wavelengths is selected from the wavelength range 790-815 nm, and the ratio of the transmittance and/or scattering power of the at least two wavelengths is calculated, this ratio serving in relation to the blood temperature as indicator value for reading off the blood glucose concentration from the calibration table. | 11-25-2010 |
20100298674 | PROTECTIVE SHELL FOR AN IN VIVO SENSOR MADE FROM RESORBABLE POLYMER - An implantable device with in vivo functionality, where the functionality of the device is negatively affected by the inflammation reaction generally associated with tissue injury, encapsulated by a protective coating that prevents damage to the device from any inflammation reactions. The protective coating is designed to persist for a set period of time, generally until after the inflammation reaction of the surrounding in vivo environment in response to the injury caused by the implantation procedure has concluded. The protective coating is further designed to “resorb” (i.e. to dissociate from the device, dissolve, and be absorbed into the surrounding environment) after a set period of time, allowing the device to perform its in vivo functionality unhindered without loss of performance. | 11-25-2010 |
20100324382 | CLOSED-LOOP GLUCOSE AND/OR INSULIN CONTROL SYSTEM - Disclosed are a method and/or system for determining a suggested change in a recommended therapy for a patient based, at least in part, on sensor measurements, and generating an alert to an attendant in a hospital environment upon detection of the suggested change. In another embodiment, a method and/or system is directed to automatically determining a maximum interval to alert an attendant following receipt of a measurement at an operator interface. In yet another embodiment, a method and/or system is directed to blood-glucose sensor calibration. | 12-23-2010 |
20100324383 | System for In Vivo Biosensing Based on the Optical Response of Electronic Polymers - A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing. | 12-23-2010 |
20100331637 | Method and System for Measuring a Composition in a Blood Fluid | 12-30-2010 |
20110004080 | METHOD FOR NON-INVASIVE ANALYSIS OF A SUBSTANCE CONCENTRATION WITHIN A BODY - Embodiments of the present methods measure a concentration of a substance, such as glucose, in a body. The described embodiments change the temperature of the surface of a body from a first temperature to a second temperature, then change the temperature of the surface of the body from the second temperature back to the first temperature, and measure a first amount of infrared (“IR”) radiation absorbed or emitted from the surface of the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the surface of the body in a second wavelength band at predetermined time intervals during the time period that the temperature of the surface of the body changes from the second temperature back to the first temperature. The described embodiments also measure a temperature at the surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is determined by correlating the normalized ration parameter with the body surface temperature and the ambient temperature. | 01-06-2011 |
20110009720 | Continuous whole blood glucose monitor - A portable continuous whole blood glucose monitor comprising, a mid-infrared quantum cascade laser and driver in optical communication with a transmission cell and a photo-conductive detector and pre-amplifier. The monitor further comprises a peristaltic pump connected to a single lumen catheter peripherally inserted into a patient's vein. The single lumen catheter, in combination with the peristaltic pump, is operable to automatically withdraw a fixed and metered amount of whole blood from a patient, then a tube delivers a fixed and metered amount of the saline/surfactant supply to the whole blood. Methods of enhancing measurement sensitivity are also provided. | 01-13-2011 |
20110021891 | NON-INVASIVE GLUCOSE MONITOR - In a non-invasive glucose monitor is configured to, by using a heat conductive member having a body surface contacting part for contacting a surface of a human body at its one end, measures a first temperature adjacent to the body surface contacting part and a second temperature adjacent to the other end apart from the body surface. The computing device takes in data of the first and second temperature, environmental temperature, radiation heat from the body surface, reflection light caused by reflecting the light of the two different wavelength at the body surface contacting part. The computing device stores a relationship between parameters and blood glucose levels in advance, thereby converts the above-mentioned data to parameters, and calculates a blood glucose level by applying the parameters to the relationship. | 01-27-2011 |
20110028806 | REFLECTANCE CALIBRATION OF FLUORESCENCE-BASED GLUCOSE MEASUREMENTS - A noninvasive or minimally invasive procedure and system for measuring blood glucose levels is disclosed. A set of photodiodes detects the fluorescence and reflectance of light energy emitted from one or more emitters, such as LEDs, into a patient's skin. In an embodiment, small molecule metabolite reporters (SMMRs) that bind to glucose are introduced to the measurement area to provide more easily detected fluorescence. | 02-03-2011 |
20110034786 | PORTABLE HANDHELD MEDICAL DIAGNOSTIC DEVICES - A portable handheld medical diagnostic device includes a front housing and a rear housing opposite the front housing. The front housing and the rear housing form a protective enclosure. A main circuit board is located in the protective enclosure. The main circuit board includes a controller facilitating a physiologic measurement. A display device is connected to the main circuit board that displays information related to the physiologic measurement. A frame is located in the protective enclosure that carries the display device and locates the display device adjacent the front housing such that the display device can be viewed from outside the protective enclosure. The frame includes a strip port formed integrally therewith that is accessible from outside the protective enclosure. | 02-10-2011 |
20110034787 | Device for Interstitial Fluid Extraction, Production Process Thereof and Analyzing Process of Interstitial Fluid Using the Device - A device for interstitial fluid extraction, having a base material formed from a synthetic resin film, a pressure sensitive adhesive layer, a hydrogel layer formed from at least one hydrophilic polymer selected from the group consisting of polyvinyl alcohol and polyvinyl pyrrolidone, and a release layer, wherein the hydrogel layer has an area of a size that the pressure sensitive adhesive layer is exposed from around the hydrogel layer, does substantially not contain a sodium ion and causes no water separation. | 02-10-2011 |
20110060199 | DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED - The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained. | 03-10-2011 |
20110087083 | ANALYTE MONITORING USING ONE OR MORE ACCELEROMETERS - The present disclosure relates to methods, devices, and systems for measuring a blood analyte, such as glucose. The disclosure relates more specifically to the use in such methods, devices, and systems of one or more accelerometers to aid in the collection of data, operation of the device, filtering, and other uses. In some embodiments, the accelerometers are three-dimensional accelerometers. An accelerometer can be used in conjunction with analyte monitoring that may be performed with infrared, near infrared, or other wavelength spectroscopy. The accelerometer may allow a monitoring instrument to expect noisy measurement data, indicate positioning of a measurement site for improved expected results, indicate position of the instrument, or help the user properly place or control the instrument. It may also improve analyte monitoring by providing motion information that can be used to help determine and reduce or remove movement-related signal artifacts or noise that may be present within the monitoring signal. | 04-14-2011 |
20110105866 | OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT - Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled. | 05-05-2011 |
20110105867 | OPTICAL SENSOR FOR DETERMINING THE CONCENTRATION OF AN ANALYTE - A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam (B1) to irradiate a portion ( | 05-05-2011 |
20110118570 | OPTIC SENSOR DEVICE WITH SERS - The present invention relates to a system for determining a concentration of a substance of interest in a body fluid, more specifically to systems comprising sensor devices for optically detecting compounds such as glucose. The system of the present invention is, e.g., suitable for continuous determination of a concentration of a substance of interest which is present in a body fluid, e.g. a concentration of glucose in blood or interstitial fluid. | 05-19-2011 |
20110118571 | METHOD OF PERFORMING WAVELENGTH MODULATED DIFFERENTIAL LASER PHOTOTHERMAL RADIOMETRY WITH HIGH SENSITIVITY - Methods are provided for the detection of an analyte in a sample using wavelength modulated differential photothermal radiometry with enhanced sensitivity. A wavelength modulated differential photothermal radiometry system, comprising two optical modulated beams, where each beam experiences different absorption by the analyte, is calibrated by controlling the relative phase difference between the modulated beams so that individual photothermal signals corresponding to each modulated beam are 180° out of phase, corresponding to peak sensitivity to analyte concentration. The system may be further calibrated by varying the relative intensities of the two modulated beams and measuring standards containing known analyte concentration in order to determine an optimal relative intensity for a given concentration range of interest. | 05-19-2011 |
20110137141 | Wireless Monitoring of Multiple Vital Signs - Devices, systems and methods are presented for monitoring a plurality of vital statistics, sending the statistics over a communications network, and generating real-time feedback for the user. A device includes a microcontroller, a transceiver, a plurality of logic units, a plurality of transducers, and a plurality of sensors. The sensors measure a plurality of vital statistics for a user. Alerts are communicated to the user via a speaker. Audio signals are detected via a microphone and processed by the logic. The transceiver enables wireless communication, directly or across a network. The transceiver further communicates with a wireless communication device. The plurality of health sensors includes a thermometer, a pulse oximeter, and a blood glucose meter. | 06-09-2011 |
20110152647 | DIODE LASER DEVICE FOR THE NON-INVASIVE MEASUREMENT OF GLYCAEMIA - A device has two diode laser sources in a range between 500 and 1000 nm, with a power in the range between 0.01 to 100 mW. Rays from the sources are conveyed through an optical condenser and, starting up a key, are emitted either on a nail or on the skin or even on a free blood sample. A photodiodic sensor or a CPU read the energy subtracted by glycate haemoglobin and free plasmic glucose. This value is converted into the immediate glycaemia value and appears on a device display. | 06-23-2011 |
20110184259 | Fiber Optic Device for Sensing Analytes and Method of Making Same - A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel. | 07-28-2011 |
20110184260 | Methods and Apparatuses for Noninvasive Determinations of Analytes - The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness. | 07-28-2011 |
20110190607 | METHODS AND SYSTEMS TO CORRECT FOR HEMATOCRIT EFFECTS - Described and illustrated herein are exemplary methods of operating an analyte measurement system having a meter and a test strip. Such methods may be exemplarily achieved by determining a first glucose concentration by measuring a first reflectance at about a first wavelength at a testing surface of the pad; measuring a second reflectance at about a second wavelength; formulating at least one equation to correct the first glucose concentration for temperature or hematocrit effects using the second reflectance at about the second wavelength; determining a second glucose concentration using the first glucose concentration, the second reflectance at about a second wavelength; and displaying the second glucose concentration that is corrected for temperature and hematocrit effects. | 08-04-2011 |
20110190608 | OPTICAL SENSOR FOR MEDICAL DEVICE - An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The size of at least one of emit and receive module lenses of an optical sensor, and the offset between the opto-electronic component and the respective lens of at least one of emit and receive modules is decreased to increase amplitude of the signal received by the receive module from the emit module. | 08-04-2011 |
20110190609 | OPTICAL SENSOR FOR MEDICAL DEVICE - An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. An optical sensor connected to a housing of a medical device includes a circuit board, an opto-electronic component, a wall, a lens, and a ferrule. The circuit board is arranged within the housing. The opto-electronic component is mounted on a surface of the circuit board. The wall protrudes from the surface of the circuit board and surrounds the opto-electronic component. The lens is offset from the surface of the circuit board. The ferrule is connected to the housing, the lens and the wall. An inner surface of the wall mates with an outer surface of the ferrule. | 08-04-2011 |
20110263954 | NONINVASIVE BLOOD GLUCOSE METER - A noninvasive blood glucose meter for testing a blood glucose level of a living organism includes a casing, a printed circuit board and a display device. The casing includes a containing space, and the printed circuit board is installed in the containing space and includes a control unit and a memory unit, and the printed circuit board is electrically coupled to a light emitting device and a light receiving device, and the light emitting device is capable of emitting a light beam, and the light receiving device is provided for receiving a reflected light beam. After the light beam emitted from the light emitting device is entered into the testing living organism, reflected from the testing living organism, and received by the light receiving device, the light beam is passed through and processed by the control unit, and then displayed on a display device and stored in the memory unit. | 10-27-2011 |
20120016214 | CALIBRATION METHOD FOR CALIBRATING AN INSTRUMENT FOR MEASURING BIOGENIC SUBSTANCE, USING NEAR-INFRARED SPECTRAL SPECTROSCOPY - A simple calibration method for calibrating an instrument for measuring a biogenic substance, using near-infrared spectral spectroscopy is realized. The calibration method comprises (1) the step of measuring a specific substance of a biological object with the use of an instrument for measuring a biogenic substance, using a confocal optical system, (2) the step of using an instrument for measuring a biogenic substance, using near-infrared spectral spectroscopy, thereby measuring a specific substance in the same region of the biological object, (3) the step of comparing a measured value of the specific substance, measured in the step (1) with a measured value of the specific substance, measured in the step, and (4) the step of executing an operation in the step at least once after the elapse of predetermined time. | 01-19-2012 |
20120016215 | SYSTEM AND METHOD FOR DYNAMICALLY ADJUSTING PATIENT THERAPY - A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved. | 01-19-2012 |
20120016216 | REAL-TIME MICRODIALYSIS SYSTEM - Microdialysis systems and methods that enable self-diagnostic functions for microdialysis, including continuous monitoring of diffusion, convection, and osmosis, as well as providing intelligent flow rate control, to mitigate variability in analyte recovery. The microdialysis system measures real-time tracer concentration levels in the dialysate and/or real | 01-19-2012 |
20120022347 | USING MUSCLE TENSION SENSING TO LOCATE AN ANALYTE MEASUREMENT SITE ON THE SKIN - Apparatus for determining where to locate a measuring device ( | 01-26-2012 |
20120029327 | Controlling Diabetes with a Cellular GPRS-Linked Glucometer-Pedometer - The Cellular GPRS system includes a cellular-based Glucometer (CBG) for blood glucose monitoring, a pedometer for exertion measurement, combined with user-entered dietary or other diabetes-relevant information. Data from all inputs is transmitted over a cellular network, using a GPRS or other wireless link. The data is preferably stored in the device prior to being transmitted wirelessly over the cellular airway to a central computer server. The remote computer server will evaluate the data received and respond with a data packet (making recommendations on further glucose measurement, exercise, diet, insulin requirements or other). | 02-02-2012 |
20120029328 | FLUORESCENCE SENSOR, NEEDLE-TYPE FLUORESCENCE SENSOR, AND METHOD FOR MEASURING ANALYTE - A needle-type fluorescence sensor that measures glucose based on fluorescence produced by excitation light is provided. The needle-type fluorescence sensor includes a needle body section including a sensor portion disposed in a needle distal end portion and metal lines disposed from the sensor portion to a needle proximal end portion, and a connector which is integrated with the needle body section and in which the metal lines extend. The sensor portion includes a silicon substrate having first and second principal surfaces, a PD device that converts fluorescence into an electric signal, an LED device that transmits fluorescence and emits excitation light, and an indicator layer that interacts with an analyte under the excitation light to produce fluorescence. The PD device, the LED device, and the indicator layer overlap with each other above the first principal surface of the silicon substrate. | 02-02-2012 |
20120035442 | PORTABLE RAMAN DIAGNOSTIC SYSTEM - The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general. | 02-09-2012 |
20120059232 | IMPLANTABLE OPTICAL GLUCOSE SENSING - Apparatus is provided, including a support ( | 03-08-2012 |
20120101347 | CONCENTRATION DETERMINATION APPARATUS, CONCENTRATION DETERMINATION METHOD, AND PROGRAM - A concentration determination apparatus may include: an irradiation unit that irradiates short-pulsed light to an observed object; a light receiving unit that receives light backscattered from the observed object; a light intensity acquisition unit that acquires an intensity distribution of the light; an optical path length distribution storage unit that stores a model of an optical path length distribution in each layer of the plurality of layers of the short-pulsed light; an optical path length acquisition unit that acquires the optical path length distribution of each layer; a time-resolved waveform storage unit that stores a model of a time-resolved waveform; a light intensity model acquisition unit that acquires a light intensity model; an integral interval calculation unit that calculates a time range of an area; an optical absorption coefficient calculation and acquisition unit that calculates and acquires an optical absorption coefficient; and a concentration calculation unit that calculates the concentration. | 04-26-2012 |
20120116191 | USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL - A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control. | 05-10-2012 |
20120123230 | ANALYTE MONITORING SYSTEMS AND METHODS OF USE - Analyte monitoring systems and methods that make interstitial fluid from a patient's body available to one or more sensors disposed outside the patient's body. The monitoring systems and methods may be used in conjunction with medicament dispensing systems and methods in order to provide a feedback loop for continuous sensing of analyte levels and corresponding dispensing of medicament based on sensed analyte levels. Dispensing or pumping systems or portions thereof may be used to move a patient's interstitial fluid into communication with the one or more sensors. | 05-17-2012 |
20120130209 | Implantable Sensor Unit - A sensor unit functionally stable in an implant, for performing qualitative and/or quantitative in vivo determination of an analyte, including a connection area ( | 05-24-2012 |
20120150001 | Hyaluronic acid based glucose monitoring - The invention provides a method for using OCT human tissue scan data for tracking a scan structure in depth, follow change in structure position within an OCT scan from, for example, fasting glucose level to peak glucose level and back down again, and relate the structure position change to analyte concentration. In the preferred embodiment, the analyte of interest is glucose concentration and the target of interest is living human skin. A hyaluronic acid based mechanism is suggested for dermis thickness. Alternate embodiments of the method are presented, including curve fitting of topographic regions corresponding to trackable target features. | 06-14-2012 |
20120165625 | Device For The Transcutaneous, In Vivo Measurement Of The Concentration Of At Least One Analyte In A Living Organism - The invention relates to a device for the transcutaneous, in vivo measurement of the concentration of at least one analyte in a living organism, comprising a carrier which can be introduced into the organism, and a luminescence indicator which is immobilized on the carrier and which reacts to a change in the concentration of the analyte to be measured with a change in at least one optical property, wherein the luminescence indicator is transcutaneously connected to a source for providing the excitation radiation and a detector for detecting the measuring radiation. According to the invention, the luminescence indicator is immobilized on the outer circumference of a catheter, which is used to dispense a fluid medium, for example a medicament, into the organism or to suck up a body fluid. | 06-28-2012 |
20120165626 | DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS - Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat. | 06-28-2012 |
20120172686 | NONINVASIVE GLUCOSE SENSING METHODS AND SYSTEMS - New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively. | 07-05-2012 |
20120209094 | MONITORING BLOOD CONSTITUENT LEVELS IN BIOLOGICAL TISSUE - In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth. | 08-16-2012 |
20120215078 | METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY - One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination. | 08-23-2012 |
20120226117 | HANDHELD PROCESSING DEVICE INCLUDING MEDICAL APPLICATIONS FOR MINIMALLY AND NON INVASIVE GLUCOSE MEASUREMENTS - The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications. | 09-06-2012 |
20120226118 | IMPLANTABLE SENSOR - A sensor is described for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor comprises a photonic integrated circuit, e.g. silicon-photonics, based radiation processor for spectrally processing radiation interacting with the sample. A continuous monitoring system also is described using such a sensor. | 09-06-2012 |
20120238841 | Sample capture in one step for test strips - A test strip is provided with sample capture that provides for a one step process to achieve a lancing event, sample capture and sample transport in a sensor design that supports one step testing. In various embodiments, the present invention provides for one step testing by, (i) analyte sample capture layout; (ii) analyte sample capture and transport configurations; (iii) structures of sample capture; (iv) processes for forming sample transport, and the like. | 09-20-2012 |
20120238842 | INTEGRATED CATALYTIC PROTECTION OF OXIDATION SENSITIVE MATERIALS - An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device. | 09-20-2012 |
20120238843 | OPTICAL BLOOD GLUCOSE DETECTING APPARATUS AND OPERATING METHOD THEREOF - An optical blood glucose detecting apparatus and an operating method thereof are disclosed. The optical blood glucose detecting apparatus includes a detecting module, an assisting and strengthening module, and a data processing module. The detecting module provides an incident optical signal passing through a detected portion of skin surface into a skin interstitial fluid, captures a blood glucose optical reflection message of the skin interstitial fluid, and it interferes the blood glucose optical reflection message and the incident optical signal to generate a detected data. The assisting and strengthening module provides a physical or chemical effect on a tissue region under the detected portion to strengthen the blood glucose optical reflection message. The data processing module processes the detected data to determine a blood glucose concentration. | 09-20-2012 |
20120265038 | METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY - One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights. | 10-18-2012 |
20120277554 | APPARATUS AND METHOD FOR CREATING A STABLE OPTICAL INTERFACE - A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor. | 11-01-2012 |
20120283530 | METHOD AND APPARATUS TO DETECT CORONARY ARTERY CALCIFICATION OR DISEASE - Coronary artery calcification (CAC) occurs at an earlier age in diabetes and is a risk factor for coronary artery disease (CAD) in subjects with or without diabetes. One postulated mechanism for the increased CAC is the accelerated accumulation of advanced glycation end products (AGEs) in the vasculature. As certain collagen AGEs fluoresce, skin intrinsic fluorescence (SIF) can act as a novel maker of collagen AGEs levels. The present invention provides methods and apparatuses for detecting SIF that can be a useful marker of CAD risk and a therapeutic target. | 11-08-2012 |
20120283531 | Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence Lifetime - The present invention provides methods and apparatuses for determining a measure of a tissue state in an individual. Light emitted by tissue of the individual due to fluorescence of a chemical with the tissue detected. The invention can comprise measuring the fluorescence lifetime in either time-domain or frequency domain modes. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, for example, multivariate models can be developed that relate lifetime trends of one or more constituents to increasing propensity to diabetes and pre-diabetes. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. | 11-08-2012 |
20120289796 | Noninvasive, Accurate Glucose Monitoring with OCT By Using Tissue Warming and Temperature Control - A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure. | 11-15-2012 |
20120289797 | PHYSIOLOGICAL TREND MONITOR - A physiological trend monitor has a sensor signal responsive to multiple wavelengths of light transmitted into a tissue site. The transmitted light is detected after attenuation by pulsatile blood flow within the tissue site. A processor has an input responsive to the sensor signal and a physiological parameter output. Features are extracted from the physiological parameter output. Criteria are applied to the features. An alarm output is generated when the criteria are satisfied. | 11-15-2012 |
20120310056 | Peritoneal dialysis system - The invention relates to a peritoneal dialysis sampling system to be used together with a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity, said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity, said peritoneal dialysis sampling system comprising an automatic sampling system which is able to automatically sample volumic fractions of the dialysate contained in the peritoneum of the patient at specific time intervals in order to evaluate the peritoneal membrane characteristics and/or improve the peritoneal dialysis for a given patient. | 12-06-2012 |
20120323093 | Article and Method for Applying a Coupling Agent for a Non-Invasive Optical Probe - An article of manufacture and method for controlling the application of a coupling agent, such as a silicone oil or mineral oil, on a surface of a tissue prior to contacting the tissue with an apparatus for non-invasive optical measurement of the concentration of an analyte. The article ensures that a specific quantity of the coupling agent is deposited in a uniform layer over the entire target area of the tissue, thereby enhancing both the optical signal and the repeatability of thermal and optical coupling with the components of the apparatus. | 12-20-2012 |
20120323094 | CONTINUOUS MONITORING OF GLUCOSE AND OTHER LIVING BODY CONSTITUENTS - Methods and apparatuses for monitoring the level of glucose or other constituents in live subjects are disclosed. Stem cells are obtained from the subject and processed into cells that change their optical characteristics in response to a level of the constituent. The responsive cells are formed into clusters and implanted into in the subject's body at locations that permit optical monitoring from outside the subject's body. The implanted cell clusters are illuminated and the reflected illumination from each of the cell clusters is detected. Changes in the optical characteristics of the cell clusters that correspond to the responses of the cell clusters are identified, and the identified changes are mapped to a constituent level based on calibration data for each cell cluster. An indication of the constituent level in the subject is then output. | 12-20-2012 |
20130006069 | IMPLANTABLE OPTICAL GLUCOSE SENSING - Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described. | 01-03-2013 |
20130006070 | METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level. | 01-03-2013 |
20130006071 | METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance. | 01-03-2013 |
20130006072 | METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area. | 01-03-2013 |
20130006073 | METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample. | 01-03-2013 |
20130018238 | Enhanced non-invasive analysis system and method - The invention provides an enhanced method and system for non-invasive analysis of a target. The enhancement includes increased analytic power derived from creating a complete representation of a target using less than complete information. The invention provides a non-invasive analysis system and method that includes generating and exploiting a system model that includes a target model that accurately represents the interaction of radiant energy with a target. | 01-17-2013 |
20130035567 | PHOTOLUMINESCENT NANOSTRUCTURE-BASED SENSORS - A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte. | 02-07-2013 |
20130041237 | LIVING BODY INFORMATION MEASURING APPARATUS - A living body information measuring apparatus includes an optical system for irradiating light to a subject and detecting light from the subject, a signal processing portion for acquiring information with regard to a tissue condition of the subject based on a detecting signal of light, and a position determining portion for determining an acceptability of an irradiating position of light based on the detecting signal of light. | 02-14-2013 |
20130060105 | Orthogonally Redundant Sensor Systems and Methods - A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body. | 03-07-2013 |
20130060106 | OPTICAL SENSING SYSTEMS AND METHODS - An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units. | 03-07-2013 |
20130060107 | SUBCUTANEOUS GLUCOSE SENSOR - A glucose sensor for measurement of glucose in subcutaneous tissue, the sensor comprising: a probe for subcutaneous insertion, the probe containing an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime of less than 100 ns; a detector head which is optically connected to the probe and which is for location outside the body; a light source; and a detector arranged to receive fluorescent light emitted from the indicator system, wherein the light source and detector are optionally located within the detector head; wherein the sensor is arranged to measure glucose concentration in subcutaneous tissue by monitoring the fluorescence lifetime of the fluorophore. | 03-07-2013 |
20130060108 | METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR - The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method. | 03-07-2013 |
20130072768 | INTRAVASCULAR GLUCOSE SENSOR - A glucose sensor for intravascular measurement of glucose concentration wherein the sensor is arranged to measure glucose concentration by monitoring the lifetime of the fluorophore, the sensor comprising:—an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a life-time of less than 100 ns;—a light source;—an optical fibre arranged to direct light from the light source onto the indicator system; —a detector arranged to receive fluorescent light emitted from the indicator system; and—a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the detector. | 03-21-2013 |
20130085352 | Controlling Transfer of Objects Affecting Optical Characteristics - An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte. | 04-04-2013 |
20130090536 | ANALYTE SENSOR METHOD AND APPARATUS - Provided herein are systems, methods, and apparatuses for an analyte sensor. In one aspect, an analyte sensing device comprises a sensor body member including at least one nanopore and an optical conduit in optical communication with the sensor body member. The optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member. A photodetector is optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy. | 04-11-2013 |
20130090537 | BLOOD GLUCOSE SENSOR - A method to measure glucose within the blood of a tissue test area includes illuminating the tissue test area using a single mode light source at a point of incidence, with at least some of the light penetrating tissue at the point of incidence; calibrating the light source by adjusting a distance between the point of incidence and an axicon lens; collecting returning radiation from the tissue test area at a point offset from the point of incidence; removing tissue fluorescence using edge filters; removing additional tissue fluorescence by shifting the excitation wavelength of the single mode light source; heating the test area; and analyzing a returned Raman signal to determine the glucose within the blood. | 04-11-2013 |
20130123590 | Constituent Concentration Measuring Apparatus and Constituent Concentration Measuring Apparatus Controlling Method - An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light. | 05-16-2013 |
20130123591 | Constituent Concentration Measuring Apparatus and Constituent Concentration Measuring Apparatus Controlling Method - An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light. | 05-16-2013 |
20130158373 | SYSTEM FOR WITHDRAWING SMALL AMOUNTS OF BODY FLUID - A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin. | 06-20-2013 |
20130172698 | DEVICES AND METHODS FOR BODY FLUID SAMPLING AND ANALYSIS - Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member. | 07-04-2013 |
20130172699 | ANALYTE SENSOR WITH EXTENDED RANGE OF DETECTION - Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration. | 07-04-2013 |
20130178723 | NON-INVASIVE OPTICAL DETECTION OF BLOOD GLUCOSE BASED ON PHASE MASKS - Non-invasive [blood] glucose testing devices and testing methods without using a blood sample are disclosed and can be used for optically interrogating substances overlaid by turbid media based on wavefront manipulation by means of binary phase masking. Through altering the degree of mode conformity between the fields reaching the collection optics and the field distributions of the propagation modes of optical waveguides the disclosed method can be used to suppress the collection of short-range light originated near the collection optics while permitting unimpeded collection of light originated from sites substantially behind turbid media. | 07-11-2013 |
20130178724 | APPARATUS AND METHOD FOR PREDICTING A PARAMETER IN THE BLOOD STREAM OF A SUBJECT - An apparatus and method for predicting a parameter in the blood stream of a subject is disclosed. The apparatus includes a laser diode source arranged to emit light of at least two different wavelengths; a first optical receiver arranged to receive incident light of the two different wavelengths where the subject is not present; a second optical receiver arranged to receive transmitted or diffuse reflected light of the two different wavelengths when a desired part of the subject is present and a processor for calculating the ratio of the intensity of the received transmitted or diffuse reflected light to incident light for each of the at least two different wavelengths to provide an indication of the parameter in the blood stream of the subject. The apparatus and method are particularly suited for measuring HbA1c in an individual. | 07-11-2013 |
20130211212 | DETERMINING THE BLOOD SUGAR LEVEL IN A PATIENT BY USING AN IMPLANTABLE SENSOR AND AN ELECTRICAL FUNCTIONAL ADHESIVE BANDAGE - An implantable sensor includes a hydrogel, a glucose-binding protein and a reference molecule. The binding affinity of the reference molecule for glucose differs by at least a factor of ten from the binding affinity for glucose of the glucose-binding protein. At least one of the electromagnetic behavior and the fluorescent behavior of the glucose-binding protein and the reference molecule change when glucose is bound. An electrical functional adhesive bandage includes a measurement element for measuring at least one of electromagnetic properties and fluorescent properties. The bandage also includes a first communication element for wireless communication. Together, the implantable sensor, the bandage, and an evaluation device, which includes a computation unit, a display and a second communication element for wireless communication, form a kit for determining the blood sugar level in a patient. | 08-15-2013 |
20130211213 | DIGITAL ASIC SENSOR PLATFORM - The present invention relates to an optical sensor that may be implanted within a living animal (e.g., a human) and may be used to measure the concentration of an analyte in a medium within the animal. The optical sensor may wirelessly receive and may be capable of bi-directional data communication. The optical sensor may include a semiconductor substrate in which various circuit components, one or more photodectors and/or a light source may be fabricated. The circuit components fabricated in the semiconductor substrate may include a comparator, an analog to digital converter, a temperature transducer, a measurement controller, a rectifier and/or a nonvolatile storage medium. The comparator may output a signal indicative of the difference between the outputs of first and second photodetectors. The measurement controller may receive digitized temperature, photodetector and/or comparator measurements and generate measurement information, which may be wirelessly transmitted from the optical sensor. | 08-15-2013 |
20130211214 | CONFIGURABLE PATIENT MONITORING SYSTEM - A patient monitoring system can display one or more configurable health monitors on a configurable user interface. The health indicators are configured to display a physiological signal from a patient. The patient monitoring system can calculate ranges of values for the health indicator that correspond to a status of the patient. The health indicators can display different outputs based on the value of the physiological signal. | 08-15-2013 |
20130217983 | ANALYTE SENSOR - Embodiments provide analyte sensors, such as implantable analyte sensors, and methods of producing the same. An implantable sensor may include a base with a plurality of chambers. One or more sensor reagents may be retained within the chambers to form analysis regions. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be implanted into the dermis of a subject. One or more of the sensor reagents may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The wavelengths of light reflected from the analysis regions may be detected and analyzed to determine a target analyte concentration. One or more portions of the sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device. | 08-22-2013 |
20130217984 | METHOD AND APPARATUS FOR DETERMINING AN AUTOFLUORESCENCE VALUE OF SKIN TISSUE - A method for determining an autofluorescence value of skin tissue of a subject, comprising the steps of:
| 08-22-2013 |
20130231539 | APPARATUS AND METHOD FOR NON-INVASIVE MEASUREMENT OF A SUBSTANCE WITHIN A BODY - A system for non-invasive measurement of a substance, such as glucose, includes a detector configured to sense radiation and an optical subsystem configured to focus the radiation on a sensitive area of the detector. The system includes one or more temperature sensors attached to one or more of a plurality of elements of the optical subsystem and to the detector and two or more temperature sensors configured to measure two or more respective ambient temperatures. The one or more temperature sensors are configured to measure the temperature of the one or more elements of the optical subsystem and the temperature of the detector. A method of measuring a concentration includes detecting an infrared radiation value, measuring the temperature of the detector, one or more components of the optical system, and two or more ambient temperatures, and correlating the temperatures with calibration parameters to correct the detected infrared radiation value. | 09-05-2013 |
20130245405 | METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS - Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level with a sample present in target area based on the calculated attenuance with the processor. | 09-19-2013 |
20130261413 | EQUIPMENT FOR IN VIVO DATA ACQUISITION AND ANALYSIS - To obtain a blood sugar level accurately, the location of a blood-vessel part is specified by using a first wavelength at which absorption by hemoglobin, which is a component unique to blood, is high, and data of light absorbance measured by using a second wavelength at which absorption by glucose is high is separated into a blood-vessel part and other parts. | 10-03-2013 |
20130267798 | NONINVASIVE MEASUREMENT OF ANALYTE CONCENTRATION USING A FIBERLESS TRANSFLECTANCE PROBE - A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix using a fiberless transflectance probe is described. It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix and conducting the backscattered radiation to a detector which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix. The transflectance probe comprises a tapered tubular housing having an inner reflective surface, an optical rod having an outer reflective surface, and a detection window which serves as an interface between the probe and the surface of the sample matrix. The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue containing blood. | 10-10-2013 |
20130267799 | NONINVASIVE MEASUREMENT OF ANALYTE CONCENTRATION USING A FIBERLESS TRANSFLECTANCE PROBE - A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix using a fiberless transflectance probe is described. It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix and conducting the backscattered radiation to a detector which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix. The transflectance probe comprises a tapered tubular housing having an inner reflective surface, an optical rod having an outer reflective surface, and a detection window which serves as an interface between the probe and the surface of the sample matrix. The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue containing blood. | 10-10-2013 |
20130267800 | FLUORESCENT HYDROGEL AND METHOD FOR PRODUCING THE SAME, AND SENSOR FOR MEASURING SACCHARIDES USING THE SAME - To provide a fluorescent hydrogel having superior detectability of saccharides such as glucose and minimal invasiveness, a method for producing the same, and a sensor for measuring saccharides using the same. A florescent hydrogel having a structure represented by the following chemical formula 1, a method for producing the same, and a sensor for measuring saccharides using the same. | 10-10-2013 |
20130267801 | SENSORS WITH THROMBORESISTANT COATING - Embodiments of the present invention relate to analyte sensors comprising a heparin coating, and methods of coating analyte sensors. The heparin can be stably associated with at least a portion of a porous membrane that covers a portion of the analyte sensors. The heparin can be photochemically linked to the coating through the formation of covalent bonds. | 10-10-2013 |
20130267802 | OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT - Embodiments of the invention are directed to an optical sensor for detecting glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the glucose, such that ratiometric correction of glucose measurements for artifacts in the optical system is enabled. | 10-10-2013 |
20130289370 | METHOD AND DEVICE FOR DETECTING A BLOOD GLUCOSE LEVEL USING A ELECTROMAGNETIC WAVE - The present invention provides a method for detecting a blood glucose level of a subject using an electromagnetic wave. Because a different blood glucose level is accompanied by a different electromagnetic absorption constant, the present invention compares a detected blood glucose electromagnetic absorption constant of the subject with data in a blood glucose electromagnetic absorption constant database so as to obtain a blood glucose concentration of the subject. The present invention also provides a device for detecting a blood glucose level of the subject using the electromagnetic wave. | 10-31-2013 |
20130303866 | Detection Device for Detection a Blood Picture Parameter - A detection device for detecting a blood count parameter in a blood vessel, comprising a transmitter to inject a first transmit signal of a first frequency into the blood vessel and a second transmit signal of a second frequency into the blood vessel, a receiver to receive a first receive signal at the first frequency and a second receive signal at the second frequency, a loss detector to determine a first loss value on the basis of the first transmit signal and the first receive signal at the first frequency, and to determine a second loss value on the basis of the second transmit signal and the second receive signal at the second frequency, and a processor to determine a first frequency shift of the first loss value relative to a first reference loss value, determine a second frequency shift of the second loss value relative to a second reference loss value, and determine the blood count parameter on the basis of the first frequency shift and the second frequency shift. | 11-14-2013 |
20130310666 | DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS - Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time. | 11-21-2013 |
20130331667 | PURIFICATION OF GLUCOSE CONCENTRATION SIGNAL IN AN IMPLANTABLE FLUORESCENCE BASED GLUCOSE SENSOR - Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing. | 12-12-2013 |
20130338456 | SENSOR DEVICE FOR SENSING BODY FLUID DENSITY AND/OR MEMBRANE RESISTANCE - The present invention relates to a sensor device for measuring tensile variation against a membrane separating a liquid such as the skin on humans and animals and any other membrane separating a liquid on one of its sides. | 12-19-2013 |
20140005505 | USE OF SENSOR REDUNDANCY TO DETECT SENSOR FAILURES | 01-02-2014 |
20140012103 | LIGHT ABSORPTION COEFFICIENT DISTRIBUTION ESTIMATION DEVICE, CONCENTRATION MEASUREMENT DEVICE, AND METHOD FOR CONTROLLING LIGHT ABSORPTION COEFFICIENT DISTRIBUTION ESTIMATION DEVICE - A light absorption coefficient distribution estimation device includes a detection section and a light absorption coefficient distribution estimation section. The detection section detects the received light intensity of scattered light from a subject at a plurality of light-receiving positions that differ in distance from an irradiation position at which measurement light is applied to the subject. The light absorption coefficient distribution estimation section estimates the light absorption coefficient distribution of the subject using the received light intensity, a propagation optical path length model that specifies a propagation optical path length on a basis of the distance, and a first model that specifies the received light intensity on a basis of the distance when absorption of light is at a predetermined value. | 01-09-2014 |
20140018644 | PURIFICATION OF GLUCOSE CONCENTRATION SIGNAL IN AN IMPLANTABLE FLUORESCENCE BASED GLUCOSE SENSOR - Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing. | 01-16-2014 |
20140018645 | PHOTOACOUSTIC APPARATUS AND CONTROL METHOD THEREOF - A used photoacoustic apparatus includes: a light source capable of individually emitting light having a first wavelength at which absorption coefficients of oxyhemoglobin and deoxyhemoglobin are equal and light having a second wavelength; an acoustic detector that receives acoustic waves generated when the light having the first and second wavelengths is absorbed by an object; an absorption coefficient distribution generator that determines absorption coefficient distributions of an object interior; a blood vessel position determining unit that determines a blood vessel position from an absorption coefficient distribution corresponding to the first wavelength; an organism characteristics distribution calculator that determines an organism characteristics distribution from the absorption coefficient distributions; and a trimming unit that trims the organism characteristics distribution in accordance with the blood vessel position. | 01-16-2014 |
20140018646 | USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL - A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control. | 01-16-2014 |
20140024904 | BLOOD COMPONENT MEASURING DEVICE - A blood component measuring device includes an irradiation light source configured to emit light at least in a near-infrared region, a light receiver having such sensitivity as to receive light emitted by the irradiation light source, a holding mechanism that holds and fixes a living body part, and an arithmetic device that calculates the concentration of a blood component in the living body part. The calculating means calculates the concentration of the blood component about, of the living body part, a place where the ratio of transmitted light intensity at a first wavelength relatively easily absorbed by hemoglobin and transmitted light intensity at a second wavelength relatively poorly absorbed by hemoglobin is the minimum. | 01-23-2014 |
20140039282 | CONCENTRATION MEASURING DEVICE AND A METHOD OF CONTROLLING THE CONCENTRATION MEASURING DEVICE - A concentration measuring device, the measuring light in a wavelength region where an absorbance related to the water in the subject can be practically ignored is irradiated to the subject S by a light source. The transmitted light that was transmitted through the subject S is received in a light receiving part. An optical rotation calculation part calculates an optical rotation of the subject S by using an output signal from the light receiving part, and an absorbance calculation part calculates an absorbance of the subject S by using an output signal from the light receiving part. A concentration calculation part calculates a concentration of glucose by using a glucose measurement data related to an aqueous solution of simple glucose, a protein measurement data related to an aqueous solution of simple protein, the optical rotation calculated by the optical rotation calculation part, and the absorbance calculated by the absorbance calculation part. | 02-06-2014 |
20140046148 | ANALYTE SENSOR - Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system | 02-13-2014 |
20140046149 | ANALYTE SENSOR - Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system | 02-13-2014 |
20140051952 | FLOWOMETRY IN OPTICAL COHERENCE TOMOGRAPHY FOR ANALYTE LEVEL ESTIMATION - Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis. | 02-20-2014 |
20140051953 | ADAPTIVE CALIBRATION SYSTEM FOR SPECTROPHOTOMETRIC MEASUREMENTS - This disclosure describes, among other features, systems and methods for customizing calibration curves, parameter algorithms, and the like to individual users. An initial calibration curve generated based on a population can be used as a starting point in an algorithm for measuring a physiological parameter such as glucose. The measurement algorithm can determine one or more initial measurement values for a user based on the initial calibration curve. In certain embodiments, one or more alternative measurements, such as invasive or minimally invasive measurements, can periodically or sporadically be input into the measurement algorithm. The algorithm can use the alternative measurements to adapt the calibration curve to the individual. As a result, measurements for the individual can more accurately reflect the individual's actual parameter values. | 02-20-2014 |
20140058225 | OPTICAL DETERMINATION OF PH AND GLUCOSE - Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose. | 02-27-2014 |
20140058226 | Method and Apparatus for In Vivo Optical Measurement of Blood Glucose Concentration - A method of non-invasive measurement of the glucose concentration directly in the blood flow utilizes a combination of the differential scattering spectroscopy and confocal scanning laser Doppler microscopy. | 02-27-2014 |
20140058227 | MEASURING DEVICE, AND MEASURING METHOD - Provided are a transmissive suction mechanism ( | 02-27-2014 |
20140094666 | SYSTEM AND METHOD FOR IN VIVO MEASUREMENT OF BIOLOGICAL PARAMETERS - A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof. | 04-03-2014 |
20140094667 | NONINVASIVELY MEASURING ANALYTE LEVELS IN A SUBJECT - A method for noninvasively measuring analyte levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels. | 04-03-2014 |
20140128694 | DRY INSERTION AND ONE-POINT IN VIVO CALIBRATION OF AN OPTICAL ANALYTE SENSOR - Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration. | 05-08-2014 |
20140142400 | NON-INVASIVE REAGENTLESS GLUCOSE DETERMINATION - Non-invasive apparatus and method for determining and monitoring glucose concentrations in human subjects. Glucose level is estimated through the effect of glucose on biological cells with glucose dependencies, e.g., red blood cells. The invention is based on the interaction of such cells with oscillating electric field gradients. The response of biological cells depends on factors including shape, size, and electrical charge distribution. The field gradient causes the cells to undergo characteristic motion which is detected by light beam scattering. The autocorrelation of the scattered light is computed, and the Fourier transform (FT) is performed to produce a characteristic velocity spectrum in which the peaks are characteristic of the cell “bio-electrical” states. The glucose level is estimated through measurements of changes of FT with changes in glucose levels after calibration with standard glucose methods. | 05-22-2014 |
20140171763 | PULSE AND ACTIVE PULSE SPECTRAPHOTOMETRY - A pulse and active pulse spectraphotometry system comprises a light source adapted to illuminate a tissue site with optical radiation having a plurality of wavelengths selected from at least one of a primary band of about 1620 nm to about 1730 nm and a secondary band of about 1000 nm to about 1380 nm. | 06-19-2014 |
20140235972 | Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence - Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe. | 08-21-2014 |
20140275870 | CONTINUOUS NONINVASIVE MEASUREMENT OF ANALYTE CONCENTRATION USING AN OPTICAL BRIDGE - A method may include directing a radiation beam at a sample, the beam including two periods of radiation having different wavelengths, an analyte in a fluid within the sample having different absorption coefficients for the two different wavelengths, detecting the beam with a detector when the sample is in a first fluid state, the detector configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths, detecting the beam with the detector when the sample is in a second fluid state, the sample transitioning from the first fluid state to the second fluid state by a pulsation of the sample, obtaining estimates of an amount of fluid at the first and second fluid states, and determining an analyte concentration estimate based on the output signal and the estimate of the amount of fluid at the first and second fluid states. | 09-18-2014 |
20140275871 | WIRELESS OPTICAL COMMUNICATION BETWEEN NONINVASIVE PHYSIOLOGICAL SENSORS AND PATIENT MONITORS - Embodiments of the disclosure include a noninvasive physiological patient sensor and a patient monitor capable of wireless communication with one another. An optical communication path can be used to provide the communication path between the noninvasive physiological patient sensor and the patient monitor. The path can be maintained by one or more light sources and detectors traditionally associated with noninvasive optical sensors or by one or more additional dedicated light sources and detectors. | 09-18-2014 |
20140303463 | Methods and Apparatuses for Noninvasive Determinations of Analytes - The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness. | 10-09-2014 |
20140330097 | METHOD AND SYSTEM FOR A NON-INVASIVE MEASUREMENT OF OPTICALLY ACTIVE COMPONENT CONCENTRATION - It is disclosed a device for measuring a concentration of glucose, for example, in a translucent piece of a body, like an earlobe, a tissue connecting two fingers, a nasal ala, or a cheek. The piece is illuminated by a linearly polarized laser beam at a certain polarization direction. Consequently, a diffused radiated light is emitted from the piece, including a directed beam. The device includes a polarizing beam splitter which receives the directed beam, a lens, a sensor array, and means for connecting to a processor. The splitter splits components of the directed beam at two mutually orthogonal linear polarization directions into two polarized beams propagating at two respective different directions. The lens images the distribution of the directed beam on the translucent piece on two spatially separated groups within the sensor arrays. The processor defines pixel pairs from a first and second images which correspond to a same point on the second surface of the translucent piece, and subtracts the first pixels from the respective second pixels to get a difference image. In addition, the processor calculates the variance of the difference image, and calculates the desired concentration accordingly. | 11-06-2014 |
20140330098 | REFLECTANCE CALIBRATION OF FLUORESCENCE-BASED GLUCOSE MEASUREMENTS - A noninvasive or minimally invasive procedure and system for measuring blood glucose levels is disclosed. A set of photodiodes detects the fluorescence and reflectance of light energy emitted from one or more emitters, such as LEDs, into a patient's skin. In an embodiment, small molecule metabolite reporters (SMMRs) that bind to glucose are introduced to the measurement area to provide more easily detected fluorescence. | 11-06-2014 |
20140336481 | MULTISPOT MONITORING FOR USE IN OPTICAL COHERENCE TOMOGRAPHY - Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis. | 11-13-2014 |
20140343381 | OPACITY CONSISTENT POLYMER GRAFT FOR OPTICAL SENSOR - A sensor (e.g., an optical sensor) that may be placed within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid) within the animal. The sensor may include a sensor housing and a polymer graft including indicator molecules and covering at least a portion of the sensor housing. The opacity of the polymer graft may remain substantially the same (i.e., may have little or no variation) over time. The sensor may include a photodetector, and variation in the opacity of the polymer graft does not cause a significant change in a measurement signal output by the photodetector. The polymer hydrogel may be made of polymers including acrylic acid and/or polyethylene glycol. | 11-20-2014 |
20140350364 | OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION - Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems. | 11-27-2014 |
20140364708 | APPARATUS FOR ENHANCING THE MOLD-IN ALGORITHM - Disclosed is an apparatus for measuring the indicators of a specific ingredient in a solution. According to one embodiment of the present invention, said apparatus comprises: a signal collector for collecting a plurality of signals from a target in a selected volume of the solution. Beam splitters for splitting said signals and several designs for generating and transmitting the signals to the detectors. After the signal's detection, a mold-in algorithm is used to remove the noise. The filtered signals are used to get several indicators, which are correlated to the concentration of ingredients in the solution. This apparatus is designed to enhance the power of the mold-in algorithm. The present invention provides an apparatus for effectively measuring in-situ without the need of extracting the solution out of its original container. | 12-11-2014 |
20140371553 | SYSTEMS, DEVICES AND METHODS FOR IN SITU CALIBRATION OF IMPLANTABLE SENSORS - The systems, methods, and devices described herein generally involve monitoring and/or quantification of various analyte levels in a biological fluid using one or more implantable sensors. In various aspects, systems, methods, and devices described herein can provide for the in situ calibration and/or cleaning of such sensors when implanted in the patient. The systems and devices disclosed herein can, for example, continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and periodically calibrate and/or clean the sensor without using finger sticks or additional, invasive calibration techniques. By way of non-limiting example, systems and devices disclosed herein can enable continuous monitoring of analyte concentrations (e.g., glucose) in subcutaneous interstitial fluid for several hours to a few days. | 12-18-2014 |
20140378793 | ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. | 12-25-2014 |
20150011848 | MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described using one or a plurality of sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination. | 01-08-2015 |
20150011849 | MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH STACKED FILTERS AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property. | 01-08-2015 |
20150011850 | MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH DYNAMIC OPTICAL PATHS AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject. | 01-08-2015 |
20150018641 | Fiber Optic Device for Sensing Analytes and Method of Making Same - A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel. | 01-15-2015 |
20150018642 | TISSUE PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF - An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and/or molar absorptivity of an individual or group through the use of the speed of light and/or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and/or a skin layer thickness, such as that of the epidermis and dermis. | 01-15-2015 |
20150018643 | SYSTEMS, DEVICES, AND METHODS FOR ENERGY EFFICIENT ELECTRICAL DEVICE ACTIVATION - Systems, devices, and methods are provided for changing the power state of a sensor control device in an in vivo analyte monitoring system in various manners, such as through the use of external stimuli (light, magnetics) and RF transmissions. | 01-15-2015 |
20150018644 | MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH NON-UNIFORM DETECTOR ARRAY AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a non-uniform detector array, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The non-uniform detector array provides a multitude of distinguishable optical pathlengths, couples to a plurality of optical transmission filters, couples to a plurality of light directing micro-optics, and/or couples to an array of light-emitting diodes. | 01-15-2015 |
20150025340 | CALIBRATION CURVE CREATING METHOD AND APPARATUS FOR THE SAME, AND BLOOD COMPONENT CALIBRATION APPARATUS - A calibration curve creating method includes: (a) acquiring observation data of a plurality of samples of a living body, when near infrared light is emitted to the living body and an absorbance spectrum obtained from transmitted light or diffusely-reflected light thereof is set as the observation data; (b) acquiring content of a target component of each sample; (c) estimating a plurality of independent components when the observation data of each sample is separated into the plurality of independent components, and acquiring a mixing coefficient corresponding to the target component for each sample; and (d) acquiring a regression equation of a calibration curve. (c) includes acquiring an independent component matrix by performing processes of normalization, whitening, and independent component analysis of the observation data, and the normalization is performed after a process performed by project on null space. | 01-22-2015 |
20150031969 | SYSTEM AND METHOD FOR MONITORING ARTERIAL AND VENOUS BLOOD OXYGEN, BLOOD GLUCOSE, AND BLOOD CONSTITUENT CONCENTRATION - A system for measuring of arterial and venous blood constituent concentration based first on measuring cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart, which includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating full arterial pulse plethysmography waveforms, arterio-venous pulse plethysmography waveforms, and balance parameters. A computational device that is responsive to plethysmography waveforms generating a plurality of state space linear transfer functions by applying system identification between plethysmography waveforms at various wavelengths representing a plurality of models of the blood constituent concentration, including oxygen, carbon dioxide, hemoglobin, and glucose, and displaying related useful information. | 01-29-2015 |
20150045636 | MULTIPLEXED / PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination. | 02-12-2015 |
20150051459 | COMBINED SURFACE ENHANCED AND SPATIALLY OFFSET RAMAN SPECTROSCOPY FOR BIOMOLECULE DETECTION - The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject. | 02-19-2015 |
20150065823 | NONINVASIVE MID-INFRARED IN VIVO GLUCOSE SENSOR - A noninvasive mid-infrared in vivo glucose sensor for use in connection with the skin of a test subject is disclosed. The sensor includes a mid-infrared light source configured to deliver a light beam to the skin of the test subject, a collector element configured to collect backscattered light from the skin and direct it to the detector, and a detector element configured to measure the collected backscattered light from the skin. The mid-infrared light source may be a quantum cascade laser. The sensor may include optical fibers configured to deliver the light beam to the skin of the test subject. The collector element may be an integrating sphere or a bundle of two or more optical fibers. The sensor may also include a probe containing or connecting to optical fibers coupled to the mid-infrared light source and configured to be placed on the skin to take glucose level readings. | 03-05-2015 |
20150080685 | EQUILIBRIUM NON-CONSUMING FLUORESCENCE SENSOR FOR REAL TIME INTRAVASCULAR GLUCOSE MEASUREMENT - Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry. | 03-19-2015 |
20150112169 | FINGER-PLACEMENT SENSOR - A finger-placement sensor fixture aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor fixture has a sensor pad configured to removably install within a sensor clip. The sensor pad has a sensor cavity custom molded to the shape of an individual's fingertip. A plurality of metal strips are embedded within the sensor pad. A plurality of magnets are embedded within the sensor clip. The sensor pad metal strips are configured to align with the sensor clip magnets so that the sensor pad can be removed, disposed of, replaced and consistently aligned with the sensor clip. | 04-23-2015 |
20150112170 | DEVICE AND METHOD FOR NON-INVASIVE GLUCOSE MONITORING - A device and method for non-invasively measuring analytes and physiological parameters by measuring terahertz radiation emitted though biological tissue. Terahertz pulses are emitted from a miniaturized quantum cascade laser to a fiber optic array into the wrist of the user. A corresponding sensor on the opposite side of the wrist receives the terahertz signals that have been modified by interacting with organic molecules. The data from the sensor is compiled and analyzed on a RAM chip and logic chip, where a program uses an algorithm to compare measurements to a library of existing measurements and topographic maps generated when the user first dons the device. Once the algorithm has parsed all the data points, a value, such as blood glucose level, appears on a display of the device. The device may be equipped with a gasket to reduce ambient light from contacting the sensor. | 04-23-2015 |
20150119661 | METHOD AND APPARATUS FOR SELECTING WAVELENGTHS FOR OPTICAL MEASUREMENTS OF A PROPERTY OF A MOLECULAR ANALYTE - A system and optimization algorithm for determining the preferred operational wavelengths of a device configured for measurement of molecular analytes in a sample. Operational wavelengths are determined by solving a system of equations linking empirically defined functions representative of these analytes, spectrally dependent coefficients corresponding to these analytes, path lengths traversed by waves probing the analytes at wavelengths corresponding to the absorption level described by the functions representative of these analytes, and, optionally, a cost-function taking into account at least one of spectral separation between the operational wavelengths, manufacturability of wave source(s) producing wave(s) at operational wavelength(s), and the noise factor associated with the operation of such wave source(s). | 04-30-2015 |
20150119662 | SENSOR WITH OPTICAL INTERFACE - A device for detection or measurement of a carbohydrate analyte in fluid comprises:
| 04-30-2015 |
20150126830 | APPARATUS AND METHOD FOR CREATING A STABLE OPTICAL INTERFACE - A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor. | 05-07-2015 |
20150133752 | NEAR INFRARED FLUORESCENT SINGLE WALLED CARBON NANOTUBES AS TISSUE LOCALIZABLE BIOSENSORS - A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications. | 05-14-2015 |
20150141777 | FLUORESCENCE-BASED SENSOR WITH MULTIPLE INDICATOR GRAFTS - A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals. | 05-21-2015 |
20150141778 | COMBINATION NON-INVASIVE AND INVASIVE BIOPARAMETER MEASURING DEVICE - In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet. | 05-21-2015 |
20150148627 | Sensing of Components in Liquids - A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences. | 05-28-2015 |
20150148628 | APPARATUS AND METHOD FOR MEASURING BIOLOGIC PARAMETERS - Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel. | 05-28-2015 |
20150297144 | BLOOD SUGAR LEVEL PREDICTION DEVICE, MEASUREMENT DEVICE, BLOOD SUGAR LEVEL PREDICTION METHOD AND COMPUTER-READABLE STORAGE MEDIUM - A blood sugar level prediction device ( | 10-22-2015 |
20150342507 | SIMPLE SUGAR CONCENTRATION SENSOR AND METHOD - A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount Θ; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector. | 12-03-2015 |
20150351669 | Reduced Size Optical Coupler for Fluorescence Detection - Optical systems are disclosed for use in identifying an analyte, such as glucose in blood or interstitial fluid (ISF), using a biomaterial, such as glucose binding protein (GBP), that is brought into contact with the analyte. An optical system includes a first filter adapted to reflect light emitted from a light-emitting diode to illuminate a fluorescent body, and further adapted to transmit light emitted from the fluorescent body, and a second filter adapted to separate light transmitted by the first filter into signal band light and reference band light. | 12-10-2015 |
20150366490 | Substance Concentration Monitoring Apparatuses and Methods - A substance concentration monitoring method includes inducing a periodic change in a body surface temperature over time using a heating and/or cooling element and yielding a function of temperature that varies with time so as to exhibit a temperature derivative with respect to time that oscillates periodically. Mid-infrared radiation absorbed or emitted from the body is measured while the surface of the body exhibits the oscillating, periodic derivative. The method includes determining a measured value based on the MIR radiation measurements and determining a concentration of a substance in the body based on a correlation with the measured value. A substance concentration monitoring apparatus includes a processor that initiates operations continuously monitoring whether the concentration or the measured value are within a tolerance. The operations further include generating a warning output when the concentration or the measured value is outside the tolerance. | 12-24-2015 |
20160022178 | OPTICALLY DISCRIMINATIVE DETECTION OF MATTERS IN TISSUES AND TURBID MEDIA AND APPLICATIONS FOR NON-INVASIVE ASSAY - Non-invasive optical detection devices and techniques that use optically discriminative detection of returned probe light from a target by spatially separating the returned probe light from the deep tissue structure and the returned probe light from the skin surface and the shallow tissue structure based on different wave vector components to improve the optical detection sensitivity in detecting the returned probe light from the deep tissue structure with reduced optical interference by the returned probe light form the skin surface and the shallow tissue structure. | 01-28-2016 |
20160022179 | CONTINUOUS GLUCOSE MONITORING ON-BODY SENSOR - An on-body sensor (OBS) ( | 01-28-2016 |
20160058338 | METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR - The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method. | 03-03-2016 |
20160058340 | MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH STACKED FILTERS AND METHOD OF USE THEREOF - A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property. | 03-03-2016 |
20160089063 | COMPONENT MEASUREMENT APPARATUS AND COMPONENT MEASUREMENT METHOD - The invention is provided to suppress a deterioration in the accuracy of measuring a component in a test object, which is caused by temperature variation due to irradiation with light. A blood sugar level measurement apparatus | 03-31-2016 |
20160100777 | INTRINSIC RAMAN SPECTROSCOPY - The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy. | 04-14-2016 |
20160128612 | SPECTROSCOPIC APPARATUS FOR BIOLOGICAL MATERIAL AND SPECTROSCOPIC METHOD USING THE SAME - A spectroscopic apparatus and method for analyzing a biological material are provided. The spectroscopic apparatus may analyze a biological material which has an internal non-uniform tissue depending on a position thereof. The apparatus may include at least one detector configured to obtain respective detection spectrums corresponding to a plurality of measurement regions that are at mutually different positions of the biological material, and an information processor to determine whether the measurement regions are normal by mutually comparing the detection spectrums, or converting contribution degrees of data for a specific component of the biological material by differentiating the detection spectrums. | 05-12-2016 |
20160143564 | MEASURING DEVICE AND MEASURING METHOD FOR NON-INVASIVE DETERMINATION OF THE D-GLUCOSE CONCENTRATION - The invention relates to a measuring method and a measuring instrument for measuring raw data for determination of a blood parameter, in particular for non-invasive determination of the D-glucose concentration. The measuring device ( | 05-26-2016 |
20160183852 | SYSTEM AND METHOD FOR DETERMINING A STATE OF A BODY - The invention provides a system for determining a state of a body. A location unit that includes a carrier component having a front side and an opposing back side, an attachment device having a first portion connected to the carrier component and a second portion securing the carrier component to the body with the back side facing a surface of the body. The location unit has a camera secured to the carrier component on the back side thereof for capturing video images of a feature of the body at or below the surface of the body. A server computer system has a recording system that stores the video images on a recording medium and an analysis system connected to the recording medium and being configured to analyze the image to determine the state of the body and report back to the location device. | 06-30-2016 |
20160192867 | WEARABLE, NONINVASIVE GLUCOSE SENSING METHODS AND SYSTEMS | 07-07-2016 |
20160249836 | SAMPLE OPTICAL PATHLENGTH CONTROL USING A NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF | 09-01-2016 |
20170231536 | Non-Invasive System and Method for Measuring Blood Glucose in the Human Body Utilizing a Modified Ceramic Coaxial Resonator | 08-17-2017 |
20180020958 | APPARATUS AND METHOD FOR ESTIMATING BLOOD SUGAR BASED ON HETEROGENEOUS SPECTRUMS | 01-25-2018 |
20190142312 | NON-INVASIVE BLOOD SUGAR MEASUREMENT METHOD AND DEVICE USING OPTICAL REFLECTOMETRY | 05-16-2019 |
20190142313 | SYSTEM AND METHOD FOR NON-INVASIVE CONTINUOUS REAL-TIME BLOOD GLUCOSE MONITORING | 05-16-2019 |
20190142315 | SYSTEMS, DEVICES, AND METHODS FOR ENERGY EFFICIENT ELECTRICAL DEVICE ACTIVATION | 05-16-2019 |
20220133186 | OPTICAL GLUCOMETER - Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject. | 05-05-2022 |