| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 564161000 | Substituent Q contains benzene ring | 45 |
| 564162000 | Sulfur in substituent Q | 11 |
| 20080214868 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 09-04-2008 |
| 20080319227 | Processes for the Preparation of Modafinil and Analogs Thereof - The present invention generally relates to an improved process for preparing modafinil and analogs thereof. The process minimizes impurities and improves the overall yield by oxidizing a modafinil intermediate compound in a reaction mixture including an alcohol and an organic acid at a ratio of from about 1:1 to about 80:1 (by volume). | 12-25-2008 |
| 20090048464 | Purification of armodafinil - The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)disulfide comprising: dissolving crude armodafinil in ethanol to form a solution; adding a solvent selected from the group consisting of linear or branched C | 02-19-2009 |
| 20090312575 | Process For Preparing A Benzoylbenzeneacetamide Derivative - Disclosed is a process for preparing anti-inflammatory compound nepafenac comprising preparing a compound of formula (V) wherein a N-halosuccinimide is used as the halogenating agent, followed by desulfurization using Raney Nickel. Also disclosed is a polymorphic form B of 2-amino-3-benzoyl-α-(methylthio)-benzeneacetamide (i.e., a compound of formula (V) wherein R is methyl | 12-17-2009 |
| 20100036164 | PREPARATION OF ARMODAFINIL FORM I - Preparation of armodafinil crystalline Form I. Also provided is armodafinil having about 30% or more by weight of particles with sizes greater than about 250 μm, and about 70% or less by weight of particles having sizes less than about 250 μm, wherein of the particles having sizes less than about 250 μm, about 50% of them have diameters less than about 50 μm. | 02-11-2010 |
| 20110098505 | Process for Enantioselective Synthesis of Single Enantiomers of Thio-Substituted Arylmethanesulfinyl Derivatives by Asymmetric Oxidation - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 04-28-2011 |
| 20120123161 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 05-17-2012 |
| 20130066111 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 03-14-2013 |
| 20130096345 | Modafinil Compositions - Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy. | 04-18-2013 |
| 20130274521 | PROCESS FOR THE PREPARATION OF AND CRYSTALLINE FORMS OF OPTICAL ENANTIOMERS OF MODAFINIL - The invention relates to a polymorphic form of (−)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 Å, and a process for the preparation thereof. | 10-17-2013 |
| 20140031589 | PROCESS FOR THE PREPARATION OF AND CRYSTALLINE FORMS OF OPTICAL ENANTIOMERS OF MODAFINIL - The invention relates to a polymorphic form of (−)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 Å, and a process for the preparation thereof. | 01-30-2014 |
| 564163000 | Nitrogen in substituent Q | 15 |
| 20080214869 | Processes for purification of tigecycline - The invention is directed to improved processes of purifying tigecycline. | 09-04-2008 |
| 564164000 | The substituent nitrogen is an amino nitrogen attached indirectly to a ring by acyclic nonionic bonding | 10 |
| 20090209787 | METHOD OF PREPARING CHIRAL CYCLIC BETA-AMINOCARBOXAMIDES - The present invention encompasses a process for preparing compounds of formula (1), wherein a compound of general formula (2) is reacted in the presence of a catalyst and a solvent under hydrogen pressure to form a compound of general formula (1) and wherein A and R | 08-20-2009 |
| 20100016636 | PROCESS FOR PREPARING OPTICAL PURE MILNACIPRAN AND ITS PHARMACEUTICALLY ACCEPTED SALTS - The present invention discloses a process for preparing optically pure milnacipran and their pharmaceutically acceptable salts, which adopts racemic milnacipran as starting material, tartaric acid derivatives and their compositions as resolving agents to resolve. | 01-21-2010 |
| 20100145099 | NOVEL POLYMORPHIC FORMS OF MILNACIPRAN HYDROCHLORIDE - The present invention relates to polymorphic forms of milnacipran hydrochloride. The polymorphic forms are designated as Form (I), Form (II), Form (III), Form (IV) and Form V of milnacipran hydrochloride. The present invention also relates to processes for the preparation of the polymorphic forms. | 06-10-2010 |
| 20100274050 | SOLID MILNACIPRAN AND PROCESS FOR THE PREPARATION OF THE SAME - The present invention provides novel solid milnacipran in crystalline form-G and a process for its preparation. The present invention also provides a process for the preparation of milnacipran hydrochloride from the novel solid crystalline milnacipran. | 10-28-2010 |
| 20100292509 | VEGFC PRODUCTION PROMOTER - A bloating ameliorant, a lymphatic vessel activator and a VEGFC production promoter comprising a tranexamic acid amide derivative and/or salt thereof. | 11-18-2010 |
| 20120184774 | PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF RACEMIC MILNACIPRAN AND ITS OPTICAL ENANTIOMERS THEREOF - The present invention relates to an improved process for the preparation of pharmaceutically acceptable salts of milnacipran by mutual acid radical exchange. | 07-19-2012 |
| 20120289744 | PROCESS FOR PREPARING OPTICALLY PURE MILNACIPRAN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention relates to an improved and commercially, viable process for the resolution of racemic cis milnacipran of formula I and its pharmaceutically acceptable salts of formula II. The present invention comprises using racemic cis milnacipran or its pharmaceutically acceptable salts as starting material, a low cost and commercially available resolving agent of formula III and industrially safe and economically low cost material such as water as a solvent. The said process results into optical isomers of racemic cis milnacipran having excellent optical purity without involving multiple crystallization steps. The present invention also comprises the concept of green chemistry as the invention works well with water as a solvent thereby minimizing the use of any other solvent. (Formular I and II should be inserted here) Wherein X is anion selected from Cl, Br, I, HSO | 11-15-2012 |
| 564165000 | Hydroxy, bonded directly to carbon, or ether in substituent Q (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 3 |
| 20120004462 | INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE - The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. | 01-05-2012 |
| 20120157712 | PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES - A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. | 06-21-2012 |
| 20160060211 | AN IMPROVED SYNTHESIS OF ANTI-PARKINSON AGENT - The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R | 03-03-2016 |
| 564166000 | Nitro in substituent Q | 1 |
| 20100249458 | Process for the manufacture of dihydropteridinones - Disclosed are processes for preparing dihydropteridinones of general formula (I) | 09-30-2010 |
| 564167000 | Hydroxy, bonded directly to carbon, or ether in substituent Q (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 2 |
| 20080300424 | 7-substituted fused ring tetracycline compounds - 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described. | 12-04-2008 |
| 20140343322 | PROCESS FOR PREPARING LEVOMILNACIPRAN HCL - The invention relates to one-pot process for preparing (1S,2R)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane of formula (I) comprising the step of reacting (1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide successively with the following reactants 1) triethyl orthoformate and methanesulfonic acid or triethylamine and methanesulfonyl chloride, 2) a phthalimidating agent, 3) aqueous EtNH | 11-20-2014 |
| 564168000 | Ring in a substituent E | 1 |
| 20110105794 | Process for the Isomerization of Semicarbazone Compounds - The present invention relates to a process for the isomerization of the Z-isomer I-Z of a semicarbazone compound of the general formula (I) into its E-isomer I-E | 05-05-2011 |
| 564169000 | Carbonyl in substituent Q | 5 |
| 20090221852 | Preparation of an Atorvastatin Intermediate - The diketone of atorvastatin is prepared by first washing a reaction vessel with a non-ketonic solvent, especially tetrahydrofuran, to remove water. 4-fluorobenzaldehyde is then reacted with benzylidine isobutyryl acetanilide in the reaction vessel to form 4-fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,beta-diphenylbenzene-butanainide | 09-03-2009 |
| 20110077430 | Method and precursor for production of no-carrier-added N-(4-[18F] fluorobutyl)-Ethacrynic amide - The present invention is related to a precursor for no-carrier-added fluorine-18 labeled ethacrynic acid, N-(4-[ | 03-31-2011 |
| 20130184493 | PROCESS FOR PREPARATION OF 4-FLUORO-alpha-[2METHYL-L-OXOPROPYL]-gamma-OXO-N-beta-DIPHENYLBENZENE BUTANE AMIDE - A process for preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-n-β-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature −25° C. to 50° C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base. | 07-18-2013 |
| 20140081047 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X-[Q-W—(CH═CH) | 03-20-2014 |
| 20160083337 | CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E. COLI AND INHIBITORS THEREOF - The crystal structure at 2.16 Å resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from | 03-24-2016 |
| 564170000 | Hydroxy, bonded directly to carbon, or ether in substituent Q (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 9 |
| 20110178340 | IMPROVED PROCESS FOR THE PRODUCTION OF BIMATOPROST - The present invention relates to a process for the purification of crude bimatoprost to obtain pure bimatoprost comprising a chromatography, preferably a chromatography using an achiral stationary phase and an eluent comprising an alcohol and an apolar solvent; and crystallisation of the product obtained the chromatography to obtain pure bimatoprost. | 07-21-2011 |
| 564171000 | Plural rings in substituent Q | 2 |
| 20120029235 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN - The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation. | 02-02-2012 |
| 20160145207 | NOVEL PROCESSES FOR THE PREPARATION OF PROSTAGLANDIN AMIDES - The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, | 05-26-2016 |
| 564175000 | Oxygen, bonded directly to the benzene ring, is part of an acyclic chain between the benzene ring and the carbonyl | 2 |
| 20090043129 | POTENT AND SELECTIVE LIGANDS OF CANNABINOID RECEPTORS - The present invention relates to high affinity compounds, able to bind CB | 02-12-2009 |
| 20100121107 | CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E. COLI AND INHIBITORS THEREOF - The crystal structure at 2.16 Å resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from | 05-13-2010 |
| 564176000 | Benzene ring bonded directly to the carbonyl | 4 |
| 20090177008 | NOVEL PROCESS FOR SYNTHESIS OF ITOPRIDE AND ITS NOVEL INTERMEDIATE N-(4-HYDROXYBENZYL)- 3,4-DIMETHOXYBENZAMIDE - The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide—known as Itopride, via a novel intermediate N-(4˜hydroxybenzyl)-3,4-dimethoxybenzamide. | 07-09-2009 |
| 20110130591 | STEROSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS - A process for synthesis of a compound of Formula (X) | 06-02-2011 |
| 564177000 | Hydroxy bonded directly to the benzene ring (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 2 |
| 564179000 | Benzene ring in a substituent E | 2 |
| 20100274051 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR - A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or α pharmacologically acceptable salt as an active ingredient: | 10-28-2010 |
| 20130072720 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF OSTEOARTHRITIS - A pharmaceutical composition including 2-hydroxy-N—[3-(trifluoromethyl)phenyl]benzamide and used for treatment of osteoarthritis is revealed. The pharmaceutical composition inhibits tumor necrosis factor (TNF) induced interferon regulatory factor (IRF). The activated IRF stimulates chondrocytes to secret matrix metalloproteinases, inducible nitric oxide synthase (iNOS), aggrecanases, etc. This leads to loss of collagen II and further causes degradation of proteoglycan. By suppression of signaling pathways of interferon regulatory factor, symptoms are relieved and osteoarthritis is treated. | 03-21-2013 |
| 564180000 | Polycyclo ring system in substituent Q | 1 |
| 20100286445 | METHOD OF FINISHING ORGANIC PIGMENTS - A method of finishing an organic pigment that involves dissolving or dispersing the pigment in a mineral acid and crystallizing the pigment from the solution or dispersion by mixing with an aqueous diluent in the absence of a sulfonato-functional condensation product of an arylsulfonic acid and an aliphatic aldehyde as crystallization inhibitor, which comprises ripening the crystallized organic pigment in the presence of a surfactant or in the presence of a pigment solubility enhancer in aqueous suspension. | 11-11-2010 |
| 564182000 | Substituent Q is monocyclic | 4 |
| 20090105503 | Process for Preparing organic compounds - Process for preparing a compound of the formula (I) in which R | 04-23-2009 |
| 20110071315 | PROCESSES FOR THE PREPARATION OF AMIDES - The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst. | 03-24-2011 |
| 564183000 | The ring is bonded directly to the carbonyl | 2 |
| 20150099900 | PROCESS FOR PRODUCING AMIDE COMPOUNDS - An efficient and eco-friendly process for producing amide compounds comprising contacting a primary amine with molecular oxygen-containing gas, solvent and ammonia solution in the presence of a non-precious metal-containing ordered, mesoporous solid catalyst is disclosed. | 04-09-2015 |
| 564184000 | Benzene ring in a substituent E | 1 |
| 20120302790 | Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives - The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A). | 11-29-2012 |
