Class / Patent application number | Description | Number of patent applications / Date published |
562567000 | Oxy, aldehyde, or ketone | 18 |
20090036709 | METHOD FOR PRODUCING 5-AMINOLEVULINIC ACID HYDROCHLORIDE - A method for producing crystals of 5-aminolevulinic acid hydrochloride wherein, in carrying out adsorption of 5-aminolevulinic acid contained in a crude 5-aminolevulinic acid solution by a cation exchange resin and its subsequent desorption with an aqueous solution containing ammonium ion, a high purity 5-aminolevulinic acid aqueous solution is obtained using a change in electric conductivity or pH of the desorption liquid as the index, and chloride ion is added to the aqueous solution which is then mixed with an organic solvent. | 02-05-2009 |
20090112019 | METHOD FOR PRODUCING BETA-HYDROXY AMINO ACID AND ENZYME USED THEREFOR - A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and | 04-30-2009 |
20090143616 | Process for Producing Carnitinamide - A process for producing carnitinamide which is an intermediate for production of L-carnitine is provided, which can hydrate carnitine nitrile to form carnitinamide with high selectivity, whereby highly-purified carnitinamide excellent as a substrate for stereoselective hydrolysis by optical resolution or a microorganism is produced in high yield. The process comprises hydrating carnitine nitrile to form carnitinamide using a catalyst containing a manganese oxide, and thus carnitinamide substantially free from by-produced carnitine is produced in high yield, so that carnitinamide of extremely high purity can be obtained through simple and easy crystallization operation. | 06-04-2009 |
20090264675 | BIOLOGICAL BUFFERS WITH WIDE BUFFERING RANGES - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 10-22-2009 |
20100036158 | NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER - The present invention relates to a novel process for the production of 3-amino-5-fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4-oxopentanoic acid, represented by the following formula (1): wherein R1 and R2 are as defined in the Description. | 02-11-2010 |
20100105948 | HOP ALPHA ACID OR HOP OIL CONTENT ENHANCER - To provide a hop alpha acid or hop oil content enhancer, which increases the content of a hop alpha acid or a hop oil. | 04-29-2010 |
20110245537 | L-carnitine calcium fumarate, preparation method and application for the same - L-carnitine calcium fumarate and its preparation and applications are disclosed in the present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the L-carnitine calcium fumarate as proposed having the advantages of being non-hygroscopic, stable in chemical property, and suitable for oral administration. A preparing method is as follow: fumaric acid is suspended in water and calcium base is added. The resulting mixture is heated up to 70˜90° C. and kept under stirring for 2˜8 hours, and then concentrated under reduced pressure. The resulting dried substance is added into ethanol, and the mixture is vigorously stirred. The inner salt of L-carnitine is added, and the mixture is reacted for 1˜6 hours at 60˜70° C. and then cooled for 2˜8 hours. L-carnitine calcium fumarate is obtained by filtration. | 10-06-2011 |
20110263897 | PREPARATION METHOD OF HIGH-PURITY L-CARNITINE - The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of quality control in different steps of chiral medicine production. The method comprises the following steps of: monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral column and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derviation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomerless than 2%. | 10-27-2011 |
20120004458 | SYNTHESIS OF RARE EARTH METAL EXTRACTANT - A rare earth metal extractant in the form of a dialkyl diglycol amic acid is synthesized by reacting diglycolic anhydride with a dialkylamine in a synthesis medium. A molar ratio (B/A) of dialkylamine (B) to diglycolic anhydride (A) is at least 1.0. A non-polar or low-polar solvent in which the dialkyl diglycol amic acid is dissolvable is used as the synthesis medium. | 01-05-2012 |
20120004459 | SYNTHESIS OF RARE EARTH METAL EXTRACTANT - A rare earth metal extractant in the form of a dialkyl diglycol amic acid is synthesized by reacting diglycolic anhydride with a dialkylamine in an aprotic polar solvent, with a molar ratio of dialkylamine to diglycolic anhydride being at least 1.0, and removing the aprotic polar solvent. | 01-05-2012 |
20130123534 | METHOD FOR SYNTHESIZING RARE EARTH METAL EXTRACTANT - A rare earth metal extractant containing, as the extractant component, dialkyldiglycol amide acid which is excellent in breaking down light rare earth elements is reacted in diglycolic acid (X mol) and an esterification agent (Y mol) at a reaction temperature of 70° C. or more and for a reaction time of one hour or more such that the mol ratio of Y/X is 2.5 or more, and is subjected to vacuum concentration. Subsequently, a reaction intermediate product is obtained by removing unreacted products and reaction residue. Then a nonpolar or low-polar solvent which is an organic solvent for forming an organic phase during solvent extraction of the rare earth metal and which is capable of dissolving dialkyldiglycol amide acid is added as the reaction solvent, and the reaction intermediate product is reacted with dialkyl amine (Z mol) such that the mol ratio of Z/X is 0.9 or more. | 05-16-2013 |
20130158293 | CANCER HEAT THERAPY-ENHANCING AGENT - Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): | 06-20-2013 |
20140275624 | PREPARATION OF 4-AMINO-2,4-DIOXOBUTANOIC ACID - A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding 2-cyano-3-hydroxy-butenedioate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. | 09-18-2014 |
20150065750 | Preparation of 4-Amino-2,4-Dioxobutanoic Acid - A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. | 03-05-2015 |
20150126775 | PROCESS FOR THE PRODUCTION OF CARNITINE FROM BETA-LACTONES - The invention relates to a method for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile. | 05-07-2015 |
20160011203 | HEXANOYLGLYCINE AS BIOMARKER FOR THE PREDISPOSITON FOR WEIGHT GAIN AND OBESITY | 01-14-2016 |
562568000 | Polycarboxylic | 2 |
20110137079 | METAL OXIDE-CHELATING LIGANDS - A compound having the formula below. The values n and m are independently selected positive integers. | 06-09-2011 |
20150065751 | Preparation of 4-Amino-2,4-Dioxobutanoic Acid - A first process for synthesizing 4-amino-2,4-dioxobutanoate involves reacting a dialkyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding an alkyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoate. A second process for synthesizing 4-amino-2,4-dioxobutanoate involves reacting a dialkyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding acetonitrile to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product in the form of an alkali salt of the formula ethyl 3-cyano-2-oxopropenolate, and then isolating the ethyl 3-cyano-2-oxopropenolate , and afterward either (a) reacting the ethyl 3-cyano-2-oxopropenolate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoate; or (b) reacting the ethyl 3-cyano-2-oxopropenolate with hydrogen peroxide and ion exchange resin under conditions suitable to form 4-amino-2,4-dioxobutanoate. In these processes, the 4-amino-2,4-dioxobutanoate may be acidified into 4-amino-2,4-dioxobutanoic acid. | 03-05-2015 |