| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 562560000 | Ureido, hydrazino, or nitrogen double bonded directly to carbon | 9 |
| 20090143615 | Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid - A process for the preparation of a compound of formula (I), | 06-04-2009 |
| 20100121105 | Composition and Method of synthesizing a biomolecule and its therapeutics applications - It is disclosed a method which relates to the ex-vivo of synthesizing J-Factor and its therapeutic application. In-vivo mechanism involves the secretion of Growth Hormone (GH), and its binding to the GH receptor. During enzymatic interaction between GH and the receptor, at least one of its amino acid specifically L-arginine is changed to J-factor by the bond shifting action in the guanidino group of L-arginine. Finally the GH is broken down into its respective amino acid units within the cell, and the J-Factor starts to accumulate gradually. Thus accumulated J-factor stimulates the synthesis and secretion of autocrine-paracrine IGF-1. IGF-I induces changes in the cell which prevent aging signs. The method further relates to ex-vivo synthesis of J-factor which is responsible for the changes in the cell and its administration to humans and animal. In one of the preferred embodiment the ex-vivo synthesized J-factor is administrated to the patients and the changes in the patients was observed. | 05-13-2010 |
| 20120088930 | METHODS FOR SALT PRODUCTION - The present invention provides methods to produce arginine bicarbonate more rapidly and efficiently than conventional methods. | 04-12-2012 |
| 20120095260 | Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1 - A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner. | 04-19-2012 |
| 20120095261 | Process for preparation of alpha-ketoglutaric acid - A process for preparation of α-ketoglutaric acid, which is adapted for preparing L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude α-ketoglutaratic acid aqueous solution; (c) purifying the crude α-ketoglutaratic acid aqueous solution to obtain purified α-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified α-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified α-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time. | 04-19-2012 |
| 20120296117 | METHODS FOR PRODUCTION OF HIGH CONCENTRATION OF ARGININE BICARBONATE SOLUTION AT HIGH PRESSURE - Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution. | 11-22-2012 |
| 20120302788 | METHODS FOR PRODUCTION OF ARGININE AT LOW PRESSURE - A method of producing arginine bicarbonate is provided including reacting an arginine slurry with a source of carbon dioxide gas under elevated temperature and low pressure to form a solution of at least 50% arginine bicarbonate, and recovering arginine bicarbonate from the solution. | 11-29-2012 |
| 20140171682 | Creatine hydrochloride and manufacturing method thereof - A manufacturing method for preparing creatine hydrochlorides includes the steps of using absolute ethyl alcohol as the cleaning agent to reduce production costs and to avoid harm to the human body resulting in the production process. | 06-19-2014 |
| 20140187815 | Process for preparation of l-arginine alpha-ketoglutarate 1:1 and 2:1 - A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner. | 07-03-2014 |
