| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 562493000 | Monocyclic | 21 |
| 20090209785 | Process for Production of 2,3,4-Trifluoro-5-(Iodo or Bromo)-Benzoic Acid - The invention provides a process for production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid, the process comprising a halogenation step in which direct iodination or bromination of 2,3,4-trifluorobenzoic acid is performed with an iodinating agent or brominating agent in a reaction solvent in the presence of an oxidizing agent. According to the invention, there is provided a process for convenient production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid in high yield and high purity in a highly regioselective manner. | 08-20-2009 |
| 20090240080 | PROCESS FOR THE PREPARATION OF CETP(1) - The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds. | 09-24-2009 |
| 20090270649 | PROCESS FOR ALKALINE HYDROLYSIS OF CARBOXYLIC ACID DERIVATIVES TO CARBOXYLIC ACIDS - The invention relates to a process for alkaline hydrolysis of carboxylic acid derivatives, especially carboxylic esters, to carboxylic acids, wherein, for the alkaline hydrolysis of the carboxylic acid derivatives, red mud which is produced by the Bayer process used for aluminum production is used as a reaction-promoting component, especially as a hydroxide ion source. | 10-29-2009 |
| 20100036156 | MONOLAYER-COATED SURFACES AS CATALYTIC PLATFORMS FOR ORGANIC REACTIONS - This invention provides a method for increasing the activity of catalysts. The method requires the introduction of the catalyst into nano-structured surfaces. The catalysts are introduced as functional groups in molecules forming a monolayer on a surface. A mixed monolayer of catalyst and inert molecules generates ordered domains of molecules on the surface. The catalyst is confined in regions of 0.5 nm to 3 nm in size and is surrounded by an inert material. The presence of such ordered domains that commensurate in size with the reactants, enhance the performance of the catalyst and increase the rate of the reaction. | 02-11-2010 |
| 20110251426 | SCREENING FOR SOLID FORMS BY ULTRASOUND CRYSTALLIZATION AND COCRYSTALLIZATION USING ULTRASOUND - The present disclosure relates to crystallizing a chemical substance(s) using ultrasound. Methods are provided for screening a chemical substance according to its solid forms by using ultrasound to generate new or unusual solid forms. Methods are also provided for crystallizing a chemical substance by novel techniques that include sonication. The present disclosure also relates to cocrystallization using ultrasound. Methods are provided for preparing cocrystals of an active agent and a guest by sonicating and crystallizing. Methods are also provided for screening a sample according to solid state phases (such as cocrystals and salts) and include generating a cocrystal from the sample using ultrasound. | 10-13-2011 |
| 20130211135 | METHODS OF MAKING L-ORNITHINE PHENYL ACETATE - Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms. | 08-15-2013 |
| 20140163257 | METHOD FOR REDUCING HALOGENOBENZOIC ACID ESTER USING RUTHENIUM CARBONYL COMPLEX - An object of the present invention is to provide a method for reducing a halogenobenzoic acid ester, in which dehalogenation is inhibited, by using a readily available catalyst. The method comprises reducing an ester with hydrogen gas by using an aromatic hydrocarbon as a solvent in the presence of a ruthenium complex represented by the following general formula (1): | 06-12-2014 |
| 20160168069 | 5-BROMO-2-(alpha-HYDROXYPENTYL)BENZOIC ACID SODIUM SALTS IN DIFFERENT CRYSTAL FORMS, AND PREPARATION METHOD THEREOF | 06-16-2016 |
| 562494000 | Purification or recovery per se | 2 |
| 20090118538 | PROCESS FOR PREPARATION OF PURE ACITRETIN - Processes and systems for the preparation of substantially pure acitretin based on reacting crude acitretin and an amine in presence of a suitable solvent to provide a salt that is then reacted with an organic acid to obtain substantially pure acitretin. | 05-07-2009 |
| 20140288327 | L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THEREOF - Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate. | 09-25-2014 |
| 562495000 | Additional unsaturation | 1 |
| 20140206900 | METHOD FOR PREPARING HIGH PURITY MONO-HYDROLYZED ACYL HALIDE COMPOUND - A method for preparing a high purity (e.g. greater than 70 wt. %) mono-hydrolyzed acyl halide compound as a precipitate from solution comprising the steps of preparing a solution comprising: i) at least 80 v/v % of a hydrocarbon solvent, ii) water at a molar concentration greater than its solubility limit within the solvent but less that its solubility limit in solution, iii) a tri-hydrocarbyl phosphate compound, and iv) a polyfunctional acyl halide compound at molar ratio to both water and the tri-hydrocarbyl phosphate compound of at least 1:1. | 07-24-2014 |
| 562496000 | Carboxyl, or salt thereof, not bonded directly to ring | 10 |
| 20100152486 | Method for Production of Particles of Pharmaceutical Substances and the Use Thereof - The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof. | 06-17-2010 |
| 20100152487 | AGENT AND METHOD FOR STABILIZING MEMBRANE PROTEIN - [Problems to be Solved] It is an object of the present invention to provide an agent and a method for maintaining and promoting the stability of a membrane protein, and in particular, a transporter (for example, an ABC transporter) on a cell membrane. | 06-17-2010 |
| 20100228049 | Method of fabricating mesocrystals of organic and organo-metallic compounds - The present invention fabricates mesocrystals of organic and organo-metallic compounds. Supersaturated solutions are made with different sums of an organic or organo-metallic compound and the organic or organo-metallic compound is added with an excipient. Through a water bath, mesocrystals are obtained from the supersaturated solutions with well-faceted nucleation and growth. Different polymorphisms are induced with different ratios of enantiomers. And the dissolution rate for fabricating the API is enhanced. | 09-09-2010 |
| 20100240924 | 2-ETHYL-4,6-DIMETHYL-PHENYL-SUBSTITUTED TETRAMIC ACID DERIVATIVES AS PEST CONTROL AGENTS AND/OR HERBICIDES - The invention relates to a novel 2-ethyl-4,6-dimethylphenyl-substituted tetramic acid derivatives of the formula (I) | 09-23-2010 |
| 20100261934 | Method for Preparing 2,6-Diethyl-4-Methylphenylacetic Acid - The invention relates to novel 2,6-diethyl-4-methylphenyl-substituted tetramic acid derivatives of the formula (I) | 10-14-2010 |
| 20100298598 | Method of Preparing a Molecular Sieve Composition - This disclosure provides a method of preparing a crystalline molecular sieve comprising: (a) providing a reaction mixture comprising at least one source of ions of tetravalent element Y, at least one source of alkali metal hydroxide, water, optionally at least one seed crystal, and optionally at least one source of ions of trivalent element X, the reaction mixture having the following molar composition:
| 11-25-2010 |
| 20140275617 | STEREOSPECIFIC SYNTHESIS PROCESS FOR TRETINOIN COMPOUNDS - A stereospecific synthesis process for tretinoin compounds comprises the following steps: using substituted triphenyl phosphine salt and β-formyl crotonic acid as raw material to carry out WITTIG reaction under the action of alkali; then adjusting the pH of the reaction liquid to 5-10; adding palladium compound or rhodium compound to carry out isomerization directly and obtain tretinoin compounds with desired configuration. The product yield of the process is high and the intermediate product in the reaction dose not need to be separated. The process is easy to operate and can save the production cost and as well is suitable for industrial production. | 09-18-2014 |
| 20150133684 | METHODS OF MAKING L-ORNITHINE PHENYL ACETATE - Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, intermixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms. | 05-14-2015 |
| 20150353464 | HETEROGENEOUS METAL-FREE CATALYST - The inventive concepts disclosed and/or claimed herein relate generally to catalysts and, more particularly, but not by way of limitation, to a heterogeneous, metal-free hydrogenation catalyst containing frustrated Lewis pairs. In one non-limiting embodiment, the heterogeneous, metal-free catalyst comprises hexagonal boron nitride (h-BN) having frustrated Lewis pairs therein. | 12-10-2015 |
| 20180022679 | HETEROGENEOUS METAL-FREE CATALYST | 01-25-2018 |
