| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 562433000 | Nitrogen bonded directly to carbon of organic radical (e.g., amino acids, etc.) | 73 |
| 20090281351 | NOVEL ALKOXYAMINES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN RADICAL - The invention relates to an alkoxyamine of formula (I) below: | 11-12-2009 |
| 562434000 | Nitro or nitroso | 6 |
| 20100191011 | METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXYCARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF - The present invention has its object to provide a method for producing an optically active hydroxycarboxylic acid derivative which is an intermediate important for production of medicines, agrochemicals, chemical products, and so on. The production method of the present invention comprises: carrying out a hydrogen-transfer reduction of a ketocarboxylic acid or a salt thereof by the reaction of an optically active diamine complex to produce an optically active hydroxycarboxylic acid derivative. According to the present invention, it is possible to safely and efficiently produce an industrially-useful optically active hydroxycarboxylic acid derivative. | 07-29-2010 |
| 562435000 | Plural rings | 2 |
| 20100331570 | METHOD FOR THE NITRATION OF SUBSTITUTED BENZENES IN THE PRESENCE OF PROPIONIC ACID - The aim of the invention is to provide a widely applicable method for the nitration of substituted benzenes. | 12-30-2010 |
| 20120016158 | LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME - There is provided a novel loxoprofen derivative that has no side effect such as a gastrointestinal disorder and also has excellent anti-inflammatory and analgesic effects and is represented by the following formula (I) or (II): | 01-19-2012 |
| 562437000 | Plural nitrogens | 2 |
| 20100016630 | ANTIMICROBIAL DERIVATIVES OF ANACARDIC ACID AND PROCESS FOR PREPARING THE SAME - Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity. | 01-21-2010 |
| 20100094046 | METHODS FOR PRODUCING AMINONITROBENZOIC ACIDS - Methods of producing aminonitrobenzoic acids are disclosed. A dinitrobenzoic acid may be reduced to an aminonitrobenzoic acid. In some specific embodiments, 2,6-dinitrobenzoic acid may be converted to 2-amino-6-nitrobenzoic acid. An end product may be used as an intermediate in the manufacture of various compounds including agricultural chemicals and pharmaceuticals. | 04-15-2010 |
| 562438000 | Halogen | 1 |
| 20140163256 | METHOD FOR PRODUCING NITROBENZENE COMPOUND - A method for producing a nitrobenzene compound represented by general formula (2), wherein R | 06-12-2014 |
| 562439000 | Ureido, guanido, or hydrazine | 2 |
| 20130211133 | "METHOD FOR PREPARING RAMALIN" - The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes. | 08-15-2013 |
| 20140012038 | ENANTIOMERICALLY PURE BINAPHTHOL DERIVATIVES AND METHOD FOR PREPARING THE SAME - The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate for preparing compounds 6, 6a (S-enantiomer) and 6b (R-enantiomer) of the following formula 6, which are 2,2′-binaphthol-3-aldehyde derivatives. Also, the present invention provides a method for preparing the compound of formula 1 with a very safe method at low cost. [formula 6] | 01-09-2014 |
| 562440000 | Nitrogen double bonded directly to carbon (e.g., amidine, ketimine, etc.) | 1 |
| 20110028756 | USE OF AMIDOXIME CARBOXYLIC ACID ESTERS AND N-HYDROXYGUANIDINE CARBOXYLIC ACID ESTERS FOR PRODUCING PRODRUGS - The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances. | 02-03-2011 |
| 562441000 | Plural rings bonded directly to the same carbon | 3 |
| 20100048944 | INTERACTIONS OF HEDGEHOG AND LIVER X RECEPTOR SIGNALING PATHWAYS - This invention relates to methods for using agents that are hedgehog inhibiting liver X receptor (LXR) agonists to reduce hedgehog signaling effects, such as cell proliferation, and methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention. | 02-25-2010 |
| 20120004452 | INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE - The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. | 01-05-2012 |
| 20120041227 | NEW SALTS OF DESVENLAFAXINE AND A METHOD OF THEIR PREPARATION - The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1. | 02-16-2012 |
| 562442000 | Nitrogen not bonded directly to a ring | 43 |
| 20100087677 | Compositions of tRNA and Uses Thereof - Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs. | 04-08-2010 |
| 562443000 | In same chain as carboxyl, or salt thereof | 39 |
| 20120116117 | PROCESS FOR THE PREPARATION OF MELPHALAN HYDROCHLORIDE - The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity. | 05-10-2012 |
| 20120316361 | METHOD OF RESOLUTION OF (RS)- 1,1'-BI-2-NAPHTHOL FOR OBTAINING ENANTIOMERIC PURE I.E. (S)-(-)-1,1'-BI-2-NAPHTHOL AND/OR (R)-(+)-1,1'-BI-2-NAPHTHOL VIA CO-CRYSTAL FORMATION WITH OPTICALLY ACTIVE DERIVATIVES OF y -AMINO ACIDS - Novel method for synthesis of optically pure (S)-(−)-1,1′-bi-2-naphthol and/or (R)-(+)-1,1′-bi-2-naphthol via resolution of racemic (RS)-1,1′-bi-2-naphthol through formation of co-crystal with optically active derivatives of γ-amino acids. | 12-13-2012 |
| 562444000 | Oxy | 20 |
| 20100168468 | WRINKLE-PREVENTING AND IMPROVING COMPOSITION - A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: | 07-01-2010 |
| 20120095256 | PROCESS FOR PRODUCING THREO-3-(3,4-DIHYDROXYPHENYL)-L-SERINE - The present invention provides a process for producing Droxidopa or a pharmaceutically acceptable salt thereof comprising a step of reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by the formula (1) with methylamine, whereby a process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine (common name: Droxidopa), which is useful as an agent for treatment of peripheral orthostatic hypotension or an agent for treatment of Parkinson's disease, with high production efficiency and without requiring troublesome operations. | 04-19-2012 |
| 20120130122 | PET RADIOTRACERS - The invention relates to novel | 05-24-2012 |
| 20120296113 | Process For The Preparation Of Thyroid Hormones And Salts Thereof - The present invention generally refers to a process for the preparation of L-thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agent, so to afford the related iodinated compound as disodium salt, which may represent a useful intermediate for the synthesis of the L-thyroxine mono-sodium salt, and the free form thereof. | 11-22-2012 |
| 20130041176 | STRUCTURE ASSESSMENT OF HETEROGENEOUS POLYPEPTIDE MIXTURE - Methods of analyzing glatiramer acetate (GA) to assess secondary structure, for example, alpha helical content and/or random coil content thereof are provided as are methods for preparing a composition comprising GA and methods for identifying a copolymer as GA. | 02-14-2013 |
| 20140187813 | CRYSTALLINE POLYMORPHIC FORMS OF MONOSODIUM N-[-8-(2-HYDROXYBENZOYL)AMINO]CAPRYLATE - The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC. | 07-03-2014 |
| 20140187814 | TYROSINE DERIVATIVE AND METHOD FOR PRODUCING TYROSINE DERIVATIVE - The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT | 07-03-2014 |
| 20140296566 | Simplified Radiosynthesis of O-[18F]Fluoromethyl Tyrosine Derivatives - This invention relates to the simplified radiosynthesis of O-[ | 10-02-2014 |
| 20140336410 | ETHYLENICALLY UNSATURATED MONOMERS HAVING CHELATING FUNCTIONALITY - The present invention provides novel polymerizable monomers having chelating functionality and processes to make them. In particular, the novel monomers are vinyl aminocarboxylates and are prepared by reacting iminodiacetic acid, iminodisuccinic acid, or a salt thereof and a vinyl epoxy benzene monomer. | 11-13-2014 |
| 20140350295 | METHOD OF SYNTHESIZING LEVOROTATORY P-HYDROXYPHENYLGLYCINE COMPOUNDS - The present invention relates to the field of chemical synthesis, particularly to a method of synthesizing levorotatory p-hydroxyphenylglycine compounds, which eliminates the subsequent processes of resolution, racemization processings, etc., simplifies operational steps; and acids with small organic molecule are chosen as catalyst in the second step, which not only is conducive to the realization of a industrialized production, but also makes the ee value of the end products be 88.1˜98.0% by determining the catalyst, the reaction solvent, the reactive substance, the reaction temperature, and the reaction duration; non-aqueous solvent is used in the second step, to avoid the discharging of phenol-containing waste water, thus environmental pollution is reduced. | 11-27-2014 |
| 20150094488 | PROCESS FOR THE MEASUREMENT OF THE POTENCY OF GLATIRAMER ACETATE - The subject invention provides a process for measuring the relative potency of a test batch of glatiramer acetate. In addition, the subject invention provides a process for preparing a batch of glatiramer acetate as acceptable for pharmaceutical use. | 04-02-2015 |
| 562445000 | Phenyl alanines | 3 |
| 20120123155 | BIOCATALYST FOR CATALYTIC HYDROAMINATION - The present invention relates to a method for the enzymatic hydroamination of C—C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of | 05-17-2012 |
| 562446000 | Di-oxy phenyl alanines | 2 |
| 20130261332 | PREPARATION OF ORGANIC COMPOUNDS FOR ENHANCED REACTIVITY - The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension. | 10-03-2013 |
| 20160075615 | Stabilization of Radiosynthetic Intermediates - The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of | 03-17-2016 |
| 562448000 | Plural nitrogens | 6 |
| 20090118537 | Process for the Preparation of Contrast Agents - The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques. | 05-07-2009 |
| 20090306424 | PROCESS FOR THE PREPARATION OF CONTRAST AGENTS - The present invention refers to a process for preparing a compound of formula (I) | 12-10-2009 |
| 20100016631 | METHOD FOR THE SYNTHESIS OF PEPTIDES WITHOUT SOLVENT - The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C | 01-21-2010 |
| 20100056825 | Formulations of canfosfamide and their preparation - Formulations of canfosfamide and their preparation. | 03-04-2010 |
| 20100168469 | PROCESS FOR THE PREPARATION OF N,N'-BIS(2-HYDROXYBENZYL)ETHYLENEDIAMINE-N,N'-DIACETIC ACID AND ITS DERIVATIVES - The invention relates to a process for the preparation of N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid and its derivatives of general formula (I), wherein both R have the same meaning and are selected from H, C | 07-01-2010 |
| 20120253065 | MANNICH CONDENSATION PRODUCTS USEFUL AS SEQUESTERING AGENTS - The present invention is directed to Mannich condensation product sequestering agents or mixtures of Mannich condensation product sequestering agents for use in fuels and lubricating oils. The present invention is also directed to a process for preparing the Mannich condensation product sequestering agents. The present invention is also directed to a product formed by combining, under reaction conditions, a polyisobutyl-substituted hydroxyaromatic compound, an aldehyde, an amino acid or ester thereof, and an alkali metal base to form the Mannich condensation product sequestering agent. The present invention is also directed to a lubricating oil composition, a lubricating oil concentrate, a fuel composition, and a fuel concentrate having the Mannich condensation product sequestering agents of the present invention. | 10-04-2012 |
| 562449000 | Halogen | 6 |
| 20110087049 | METHOD OF PRODUCING PURIFIED OPTICALLY ACITVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND - A method of producing a purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound which is characterized by comprising a step of making a crude optically active 4-amino-3-(substituted phenyl)butanoic acid compound contact an organic acid in the presence of water. | 04-14-2011 |
| 20110152572 | OPTICALLY ACTIVE 4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID - Provided is a new crystal A of optically active 4-amino-3-(4-chlorophenyl)butanoic acid which is far better in stability, and a process for producing the crystal and a process for producing the crystal A comprising a step of heating the following crystal B in water having a pH of 3 to 9:
| 06-23-2011 |
| 20120029230 | METHOD FOR PREPARING CHIRAL BACLOFEN - The present invention provides a novel method for preparing chiral Baclofen with higher yield, higher e.e. value, and lower cost via chiral Michael addition. | 02-02-2012 |
| 20120190887 | Processes for preparing pharmaceutical grade melphalans from industrial grade reactants - A four stage inexpensive method of preparing pharmaceutical grade Melphalans of Melphalan 2-HCl, Melphalan HCl and Melphalan by: | 07-26-2012 |
| 20160016889 | An Improved Process for the Synthesis of Melphalan and the Hydrochloride Salt - The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I). | 01-21-2016 |
| 20160090352 | PROCESS FOR THE PURIFICATION OF MELPHALAN - A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described. | 03-31-2016 |
| 562450000 | Amide | 11 |
| 20080319222 | Crystal forms of N- (trans-4-isopropylctyclohexylcarbonyl) -D-phenylalanine - New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known as nateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglinide from the solution, and isolating and drying the precipitated crystal form of nateglinide. The precipitation of nateglinide may be induced either by cooling the solution, or by addition of another solvent which is miscible with the first solvent but in which nateglinide is only poorly soluble, or by combination of the two. Depending on the solvent a specific crystal form of nateglinide may be obtained, e.g., the R′-type crystal form of nateglinide produced by the described method has a different melting point, infra red spectra and X-ray diffraction patterns from the previously known crystal forms of nateglinide. | 12-25-2008 |
| 20090069593 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid - The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. | 03-12-2009 |
| 20090076301 | METHODS FOR PRODUCING NATEGLINIDE CRYSTALS - There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide. | 03-19-2009 |
| 20090253933 | NATEGLINIDE CRYSTALS - Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble. | 10-08-2009 |
| 20110092733 | NATEGLINIDE CRYSTALS - Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble. | 04-21-2011 |
| 20130165686 | Process for the Preparation of Nateglinide - The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (−)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof. | 06-27-2013 |
| 20130178651 | PREPARATION METHOD OF HIGH-OPTICAL PURITY N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6-TRIFLUOROACETYL-L-LYSINE - Disclosed is a preparation method of high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine. The method includes: adding crude N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine to one or more organic solvents, and then reacting with an organic acid to form a salt, which is precipitated, thereby achieving the purpose of separation and purification; next, adding the obtained solid or mother concentrate into deionized water, and then adding an inorganic base or an organic base for basification, so as to adjust the pH value, removing the organic acid, filtering, washing and drying, to obtain the high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine, where the molar ratio of 1S-isomer to 1R-isomer is equal to or greater than 99:1. | 07-11-2013 |
| 20140121407 | DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE - A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient. | 05-01-2014 |
| 20140135525 | PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES - The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators. | 05-15-2014 |
| 20140378701 | PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES - The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators. | 12-25-2014 |
| 20160115118 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE - The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors. | 04-28-2016 |
| 562451000 | Oxy | 3 |
| 20090247784 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF - In one embodiment, the present application relates to a process of making a compound of formula I. | 10-01-2009 |
| 20110021814 | METHOD FOR REDUCING AMINOISOPHTHALIC ACID BISAMIDE RELATED IMPURITIES IN PREPARATION OF NON-IONIC X-RAY CONTRAST AGENTS - This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in the industrial preparation of these non-ionic X-ray contrast agents. In particular, it relates to a method for significantly removing ABA monomethylester and ABA dimer from ABA by hydrolyzing ABA under a pH between about 12 to about 13 in an aqueous medium to convert ABA monomethylester to ABA monoacid, before the iodination reaction of ABA. | 01-27-2011 |
| 20110257430 | NOVEL COCRYSTALLIZATION - The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases. | 10-20-2011 |
| 562452000 | Oxy | 9 |
| 20090043125 | STABILIZER AND METHOD FOR STABILIZING HYDROXYLAMINE, AND STABILIZED HYDROXYLAMINE SOLUTION - It is the objective to provide a method of stabilizing hydroxylamine at a high temperature and a high concentration or in a case that metal impurities such as Fe got mixed with, and a stabilized hydroxylamine solution. | 02-12-2009 |
| 20100016632 | Biphenyl acetate, preparation and uses thereof - The biphenyl acetate is biphenyl acetic ammonia butantriol salt, which is obtained by reacting biphenyl acetic acid with ammonia butantriol in organic solvent. The salt is adapted to be used for producing analgesic, anti-inflammatory and antithermic medicines. | 01-21-2010 |
| 20120004453 | Liquid Crystal Display Device And Method Of Manufacturing That - An organic solvent includes a photo decomposition type polyimide acid which forms an alignment film of a liquid crystal display device by radiation of a polarized light. A viscosity of the photo decomposition type polyimide acid is not more than 35 mPa·s. | 01-05-2012 |
| 20130060063 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3,4DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES FROM THE PRECURSOR - Disclosed is a method for producing precursors for L-3,4-dihydroxy-6-[ | 03-07-2013 |
| 562453000 | Carboxyl, or salt thereof, nitrogen and oxygen all bonded directly to the same benzene ring | 3 |
| 20110028757 | MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS - The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino] benzoic acid or its salt. | 02-03-2011 |
| 20120209025 | Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases - The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease. | 08-16-2012 |
| 20140296567 | 3-HYDROXYANTHRANILIC ACID (3-HAA) THERAPY FOR PREVENTION AND TREATMENT OF HYPERLIPIDEMIA AND ITS CARDIOVASULAR COMPLICATIONS - The present invention relates to the use of a tryptophan metabolite, 3-hydroxyanthranilic acid (3-HAA) or a functional analogue thereof, for prophylactic and/or therapeutic treatment of mammals, in special humans, against hyperlipidemia and its cardiovascular complications, i.e. atheroma formation, myocardial infarction and heart failure, ischemic stroke and transient ischemic attacks, renal impairment, aortic aneurysms and critical limb ischemia caused by atherosclerosis. | 10-02-2014 |
| 562455000 | Amide | 2 |
| 20110021815 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS - The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation. | 01-27-2011 |
| 20120059188 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS - The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation. | 03-08-2012 |
| 562456000 | Halogen | 3 |
| 20120330056 | PROCESS FOR PREPARING CHEMICAL COMPOUNDS OF INTEREST BY NUCLEOPHILIC AROMATIC SUBSTITUTION OF AROMATIC CARBOXYLIC ACID DERIVATIVES SUPPORTING AT LEAST ONE ELECTRO-ATTRACTIVE GROUP - A method for preparing aromatic carboxylic acid derivatives by nucleophilic aromatic substitution, involves reacting an aromatic carboxylic acid derivative supporting only one carboxyl function, or one of the salts thereof, the carboxylic acid derivative supporting, orthogonally to the carboxyl function, a leaving group which is a fluorine or chlorine atom or an alkoxy group, chiral or otherwise and, in the latter case, preferably a methoxy group; the carboxylic acid derivative being substituted by at least one electro-attractive group other than the leaving group, preferably by a fluorine atom, with a MNu reagent, wherein M is a metal and Nu an optionally chiral nucleophile, the nucleophilic aromatic substitution reaction being carried out without a catalyst and without a step of protecting/unprotecting the acid function of the initial compound, the method being selective in that the reaction leads to the formation of ketone derivatives in a very minority fashion during the reaction. | 12-27-2012 |
| 20130190529 | Fluorine Radiolabelling Process - The invention relates to a process for producing a process for producing an | 07-25-2013 |
| 20140296568 | PROCESS FOR THE SYNTHESIS OF DICLOFENAC CHOLINE SALT - The invention relates to a process for the production of (2hydroxyethyl)trimethylammonium [o-2,6-dichloroanilino)phenyl]acetate and to a solution of (2hydroxyethyl)trimethylammonium [o-(2,6-dichloroanilino)phenyl]acetate in ethanol that is obtainable through said process. | 10-02-2014 |
| 562457000 | Plural rings with nitrogen bonded directly to at least one ring | 3 |
| 20100160676 | PROCESS FOR THE PREPARATION OF MONOMERS FOR POLYBENZIMIDAZOLE MATERIALS - Complexes of 2,3,5,6-tetraminotoluene with an aromatic diacid are prepared by reaction with a divalent salt of the aromatic diacid while maintaining the pH of the reaction solution between 3 and 10. The resulting complexes are suitable for making high molecular weight polybenzimidazole polymers for high-performance fibers. | 06-24-2010 |
| 20140058129 | Phenylacetic Acid Derivatives - Compounds of formula (I) | 02-27-2014 |
| 20160166950 | Reaction Method Accompanied by Production of Gas Component | 06-16-2016 |
| 562458000 | Carboxyl, or salt thereof, bonded directly to a ring | 2 |
| 20090171116 | Treatment of Aqueous Liquids and the Preparation of Anthranilic Acid - A continuous process for forming an anthranilic acid which includes treating in a first step a mixture comprising a carbonate salt and an anthranilic acid salt of the formula (I) where R is selected from hydrogen and one or more substituted or unsubstituted hydrocarbon groups, and M is a univalent cation, with an inorganic acid in an aqueous medium to form an aqueous slurry comprising anthranilic acid and inorganic salts. The slurry is filtered to provide a residue comprising part of said anthranilic acid and a filtrate comprising the remainder of said anthranilic acid and said inorganic salts. Further anthranilic acid is extracted from said filtrate with a water-immiscible organic solvent, whereby the further anthranilic acid is separated into an organic phase while the inorganic salts remain in an aqueous phase. The organic phase is contacted with an aqueous alkali to thereby transfer said further anthranilic acid from said organic phase to an aqueous phase as an anthranilic acid salt. The transferred anthranilic acid salt is added to the mixture of the first step. Also disclosed is a process for the treatment of waste water containing organic material and greater than 10 g/l inorganic salts. The waste water is contacted with a volatile water-immiscible organic solvent. An organic phase is separated from an aqueous phase containing less than 0.5 g/l organic material. The organic solvent from the organic phase is evaporated to leave a residue which is incinerated. | 07-02-2009 |
| 20120296114 | PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID - The present invention relates to a preparation method of 4-aminomethylbenzoic acid comprising the following steps: preparing 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate); reacting the 4-carboxylbenzaldehyde or an alkyl ester thereof (methyl 4-formyl benzoate) with hydroxyamine to oximate the same; and contact reducing 4-carboxylbenzaldehyde oxime or an alkyl ester oxime thereof obtained by the oximation, through hydrogen in a sodium hydroxide aqueous solution. Since methyl 4-hydroxyiminomethylbenzoate is reacted as a raw material in the presence of an alkali, hydrogen of a relatively low pressure can be used and a purification process is also simple, thereby enabling preparation of 4-aminomethylbenzoic acid with a low cost and high yield. | 11-22-2012 |
