| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 560174000 | Aldehyde or ketone group in acid moiety | 25 |
| 20090209779 | Process for preparing intermediates of HMG-CoA reductase inhibitors - The present invention relates to intermediates of rosuvastatin and processes for the production thereof. | 08-20-2009 |
| 20100016627 | PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE - A 2-formylacetic ester derivative represented by the general formula (5) is provided: | 01-21-2010 |
| 20110009663 | PROCESS FOR PURIFYING AN a-KETO ESTER - Process for purifying an α-keto ester by removing secondary and tertiary alcohols from the α-keto ester. In a first step, the α-keto ester to be purified is treated with a carboxylic anhydride and an acid, which is essentially insoluble under the filtration conditions, to esterify the secondary and tertiary alcohols. Subsequent filtration to remove the acid followed by distillation affords the desired purified α-keto ester. | 01-13-2011 |
| 20110060156 | Pyruvate Derivatives with Neuroprotective Effect, Process for Preparing the Same and Pharmaceutical Composition Comprising the Same - Novel pyruvate derivatives exhibiting outstanding neuroprotective effect, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions for prevention and treatment of brain disease including them as effective ingredient are provided. | 03-10-2011 |
| 20110160479 | PROCESS FOR THE PRODUCTION OF ESTERS OF LEVULINIC ACID FROM BIOMASSES - A new process is described for the direct synthesis of esters of levulinic acid starting from biomasses containing one or more polysaccharides and from aliphatic alcohols, in the presence of a suitable organic acid catalyst. In particular, the biomasses can be lignin-cellulose biomasses. The esters thus obtained can be used as oxygenated components in the formulation of fuels for motor vehicles, with the aim of reducing the particulate emissions. | 06-30-2011 |
| 20110319653 | Intermediate of Cilastatin and Preparation Method Thereof - Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-α-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-α-hydroxyl-heptonitrile is converted to 7-halo-α-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-α-hydroxyl-heptylic acid is converted to 7-halo-α-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-α-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-α-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition. | 12-29-2011 |
| 20130197262 | TRISUBSTITUTED METHYL ALCOHOLS AND THEIR POLYMERIZABLE DERIVATIVES - Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents. | 08-01-2013 |
| 20140031581 | METHOD FOR PREPARING PYRUVATE ESTER - A method for preparing a pyruvate ester is disclosed. In the method of the present invention, a lactate ester is oxidized by hydrogen peroxide in the presence of a Ti-Si molecular sieve catalyst. In the present invention, the Ti-Si molecular sieve catalyst is easily filtered and recycled, the reaction conditions are mild due to the usage of hydrogen peroxide, the process is simple and easily performed, the conversion rate of the lactate ester is high, and the selectivity of the pyruvate ester is high. | 01-30-2014 |
| 20140039217 | Process for the Production of 4-Chloroacetoacetyl Chloride, 4-Chloroacetoacetic Acid Esters, Amides and Imides - The invention relates to process for the continuous production of 4-chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the production of 4-chloroacetoaceticacid ester, 4-chloroacetoaceticacid amide or 4-chloroacetoaceticacid imide from 4-chloroacetoacetyl chloride obtained according to the inventive process. | 02-06-2014 |
| 20140350292 | SYNTHESIS OF DIESEL FUEL BLENDSTOCK FROM CARBOHYDRATES - Carbohydrates as derived from plant biomass can be converted into mono-alcohols, diols, and/or bi-functional alcohols or into carboxylic acid derivatives. By catalytic transesterification of such carbohydrate derivatives, ester-type diesel-fuel blendstock components may be produced. More specifically, alkyl levulinates are catalytically trans-esterified with hydroxyl-functionalized compounds where both the alcohols and the alkyl levulinates are derived from biomass carbohydrates. Esters produced in this way show physicochemical characteristics that make them suitable for use as diesel fuel blendstock. | 11-27-2014 |
| 20150299094 | PROCESS AND SYSTEM FOR PREPARATION OF ESTERS OF LEVULINIC ACID - A process for converting sugars to esters of levulinic acid comprises mixing alcohol and glycerol with a feed stock comprising one or more sugars to create a reaction mixture of alcohol, glycerol and the feedstock is disclosed. The reaction mixture is contacted with an acid catalyst. The contact between the acid catalyst and the reaction mixture is maintained at an effective temperature and pressure for a specific time period so as to cause a desired reaction to result in a product stream. The product stream is separated into components by virtue of the difference in their boiling points, miscibility or specific gravity. Esters of levulinic acid, glycerol, alcohol and additional by-products are recovered from the product stream. | 10-22-2015 |
| 20150336872 | PROCESS FOR THE PURIFICATION OF CARBOXYLIC ACIDS - A process for the purification of carboxylic acid having a chain length from one to five carbon atoms is disclosed herein. The process includes transforming the carboxylic acid to its monoester and/or its diester, and processing the mono- and/or the diester of the carboxylic acid by subcritical or supercritical fluid chromatography using a subcritical or supercritical mobile phase. | 11-26-2015 |
| 20160122278 | PROCESS TO PREPARE LEVULINIC ACID - The invention describes processes to prepare levulinic acid, formic acid and/or hydroxymethyl furfural from various biomass materials. | 05-05-2016 |
| 560175000 | Preparing esters by carbonylation | 2 |
| 20150045576 | METHODS OF MAKING ALKYL LACTATES AND ALKYL LEVULINATES FROM SACCHARIDES - Unique methods have been developed to convert saccharides into value-added products such as alkyl lactates, lactic acid, alkyl levulinates, levulinic acid, and optionally alkyl formate esters and/or hydroxymethylfurfural (HMF). Useful catalysts include Lewis acid catalysts and Brønsted acid catalysts including mineral acids, metal halides, immobilized heterogeneous catalysts functionalized with a Brønsted acid group or a Lewis acid group, or combinations thereof. The saccharides are contacted with the catalyst in the presence of various alcohols. | 02-12-2015 |
| 20150126765 | MANUFACTURE OF 1-SUBSTITUTED METHYLIDENE COMPOUNDS - Compounds of the formula (I) wherein R | 05-07-2015 |
| 560176000 | Polycarboxylic acid | 6 |
| 20110313191 | Preparation of Pharmaceutical Salts of 3-0-(3',3'-Dimethylsuccinyl) Betulinic Acid - This invention relates to a novel process for making 3-O-(3′,3′-dimethylsuccinyl)betulinic acid (“DSB”). This invention also relates to methods of treating HIV and related diseases using pharmaceutical compositions comprising salt forms of DSB prepared according to the process of the present invention. The invention further relates to dosage forms of pharmaceutical compositions comprising salts of DSB made using the process of this invention. | 12-22-2011 |
| 20120004443 | PROCESS FOR PRODUCTION OF KETOMALONIC ACID COMPOUNDS OR HYDRATES THEREOF - Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization. | 01-05-2012 |
| 20120123147 | KETOCARBOXYLIC ACIDS, METHODS OF MANUFACTURE AND USES THEREOF - Ketocarboxylic acids such as levulinic acid can be efficiently purified in high yield by esterification with a hydrocarbon polyol to the corresponding polyketocarboxylic ester, which can be readily purified, for example recrystallized. After purification, the ketocarboxylic ester can be hydrolyzed to provide pure ketocarboxylic acid, or a salt thereof, after removal of the esterifying hydrocarbon polyol, or used for other synthetic transformations. Advantageously, the polyketocarboxylic esters, ketocarboxylic acids, and salts thereof produced by this method are obtained in high purity. | 05-17-2012 |
| 20130296601 | KETOCARBOXYLIC ACIDS, KETOCARBOXYLIC ESTERS, METHODS OF MANUFACTURE AND USES THEREOF - Ketocarboxylic acids such as levulinic acid can be efficiently purified in high yield by esterification with a hydrocarbon polyol to the corresponding polyketocarboxylic ester, which can be readily purified, for example recrystallized. After purification, the ketocarboxylic ester can be hydrolyzed to provide pure ketocarboxylic acid, or a salt thereof, after removal of the esterifying hydrocarbon polyol, or used for other synthetic transformations. Advantageously, the polyketocarboxylic esters, ketocarboxylic acids, and salts thereof produced by this method are obtained in high purity. | 11-07-2013 |
| 20140316156 | METHOD OF PRODUCING THERAPEUTIC AGENT - A method for producing a therapeutic agent and the agent thus produced. This therapeutic agent, referred to as D-boramine, has the following chemical formula:[(CH | 10-23-2014 |
| 20160194268 | PRODUCTION METHOD OF KETOMALONIC ACID COMPOUND | 07-07-2016 |
| 560177000 | Aldehyde group in acid moiety | 2 |
| 20110124904 | Allyl acetate hydroformylation process - A process for the production of 4-acetoxybutyraldehyde is described. The process comprises reacting allyl acetate with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a substituted or unsubstituted 2,2′-bis(dihydrocarbylphosphino)diphenyl ether. The process gives a high ratio of 4-acetoxybutyraldehyde:3-acetoxy-2-methylpropionaldehyde. | 05-26-2011 |
| 20150299095 | ALCOHOL-MEDIATED ESTERIFICATION OF CARBOXYLIC ACIDS WITH CARBONATES - A process for making esters from organic acids by means of reacting a carboxylic acid with dialkylcarbonate in an alcohol-containing solvent without any extrinsic acid or base catalyst is described. A benefit of the preparation process is that it can make the separation and extraction of ester products simpler and more facile vis-a-vis conventional isolation techniques. | 10-22-2015 |
| 560178000 | Acetoacetic acid | 2 |
| 20100121095 | METHOD FOR PRODUCING DIHALO ACETOACETIC ALKYL ESTERS - The invention relates to a process for preparing alkyl dihaloacetoacetates of the formula (I) by reacting α,α-dihaloamines of the formula (III) with acetic esters of the formula (II) in the presence of bases. | 05-13-2010 |
| 20130338394 | PROCESS FOR THE PREPARATION OF ENOLATE SALTS OF 4-FLUORO-2-HYDROXYMETHYLENE-3 OXO-BUTYRATES - Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein R | 12-19-2013 |
