| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 560024000 | Carbamic acid | 69 |
| 20080227999 | Heterogeneous Supported Catalytic Carbamate Process - A process for the preparation of aromatic carbamates comprising contacting one or more organic carbonates with an aromatic amine or urea in the presence of a catalyst and recovering the resulting aromatic carbamate product, characterized in that the catalyst is a heterogeneous catalyst comprising a Group 12-15 metal compound supported on a substrate. | 09-18-2008 |
| 20090275771 | Process for the preparation of urethanes - Urethanes are prepared by oxidative carbonylation of at least one amino compound in the presence of carbon monoxide, oxygen and organic, at least one hydroxyl-group-carrying compound. The carbonylation is carried out in the absence of halogen-containing promoters. The carbonylation is also carried out in the presence of a metal complex catalyst which contains neutral bidentate N-chelate ligands of the (N˜N) type, two monoanionic N,O-chelate ligands of the general type (N˜O) | 11-05-2009 |
| 20090281346 | METHOD FOR THE PRODUCTION OF CHIRAL AMINOCARBONYL COMPOUNDS - Disclosed is a method for producing aminocarbonyl compounds of the general formula (I) | 11-12-2009 |
| 20100036148 | Acyloxyalkyl Carbamate Prodrugs of Tranexamic Acid, Methods of Synthesis and Use - Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed. | 02-11-2010 |
| 20100113819 | Method for Making Carbamates, Ureas and Isocyanates - The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate which can be further derivitized to form non-activated carbamate or a urea. The urea or carbamate can be subjected to a pyrolysis reaction to form isocyanate. | 05-06-2010 |
| 20100217029 | Production of N-aryl Carbamates and N-aryl Isocyanates - The invention relates to a method for producing N-aryl carbamates (urethanes) and N-aryl isocyanates. According to said method, aromatic nitro compounds are subjected to a reductive carbonylation in the presence of carbon dioxide and organic compounds that bear hydroxyl groups and the carbonylation is carried out in the presence of metal complexing catalysts. Anionic N,O-chelate ligands of the general formulae [M(N˜O) | 08-26-2010 |
| 20100298592 | CATALYST FOR PRODUCING N-SUBSTITUTED CARBAMATES, AND THE PREPARATION AND APPLICATION OF THE SAME - The present invention relates to a novel catalyst for producing N-substituted carbamates, the preparation of the catalyst and an improved method for producing N-substituted carbamates from these novel catalysts. The active component of the catalyst is a heteropoly acid and the catalyst support comprises a metal oxide or a metalloid oxide. The catalyst can be used to promote the reaction of carbamate and amine, thereby generating N-substituted carbamates with high yield. In the presence of the catalyst, the reaction conditions are relatively mild, the catalytic activity and selectivity of the reaction are high, and the reaction time is relatively short. Furthermore, the catalyst can be conveniently separated from the reaction system and recycled. therefore, the catalyst can be used to facilitate the further scale-up test and commercial application. | 11-25-2010 |
| 20110124902 | PREPARATION OF CARBAMATES WITH SOLID CATALYSTS - Carbamate preparation process comprising, the reaction between at least:
| 05-26-2011 |
| 20110130587 | PROCESS FOR PREPARING R-BETA-AMINO PHENYLBUTYRIC ACID DERIVATIVES - Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%. | 06-02-2011 |
| 20110237823 | PROCESS FOR THE PRODUCTION OF AROMATIC URETHANES - A continuous process for the production of an aromatic urethane from the reaction of an aromatic amine and an organic carbonate comprising the steps of passing the aromatic amine and the organic carbonate through a fixed bed reactor containing a zinc carbonate catalyst to produce the aromatic urethane and collecting the aromatic urethane. | 09-29-2011 |
| 20120041223 | PROCESS FOR PREPARING AROMATIC CARBAMATES - The invention is directed to a process for preparing aromatic carbamates which comprises the reaction of an aromatic amine with an organic carbonate in the presence of a catalyst characterized in that Zn | 02-16-2012 |
| 20120209022 | PROCESSES FOR THE PREPARATION OF LACOSAMIDE AND INTERMEDIATES THEREOF - The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of lacosamide. | 08-16-2012 |
| 20130030210 | METHODS FOR PREPARING AMIDES AND AMINO ACIDS - The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ | 01-31-2013 |
| 20130331599 | COMPOUND FOR PREPARING 4-(10B)BORONO-L-PHENYLALANINE - Provided is a compound of the following formula (I) for preparing 4-( | 12-12-2013 |
| 560025000 | Polycarbamic | 23 |
| 20090082588 | Process for producing fluorinated carbamates and isocyanates - The invention relates to a process for producing fluorinated carbamates comprising the reaction between an amine or polyamine and a fluorinated carbonate, in the presence of a catalyst which does not contain metals and comprises at least one tertiary amine group. The process can also comprise an additional step in which the carbamates are transformed into the corresponding isocyanates. | 03-26-2009 |
| 20110004012 | METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES - The invention provides metal carbamates of the general formula (I) | 01-06-2011 |
| 20110015424 | METAL CARBAMATES FORMED FROM DIAMINOPHENYLMETHANE - The invention provides metal carbamates of the general formula (I) | 01-20-2011 |
| 20110040119 | METHOD FOR PREPARING PRECURSOR OF RADIOACTIVE 3-IODOBENZYLGUANIDINE - A method for preparing a precursor of radioactive 3-iodobenzylguanidine-N,N′-bis(tert-butyloxycarbonyl)-3-(tri-n-butyltin)benzylguanidine) (MSnBG) is revealed. The MSnBG is a precursor of [*I]MIBG that is used as radioactive imaging agents and antineoplastic drugs. The method includes following steps. Firstly, obtain 3-iodobenzylguanidine bicarbonate by an addition reaction between 3-iodobenzylamine hydrochloride and cyanamide. Use di-tert-butyl dicarbonate as a protecting agent for NH group and convert 3-iodobenzylguanidine bicarbonate into N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine. At last, under catalysis of bis(triphenylphosphine) palladium dichloride, obtain a final product MSnBG by a substitution reaction between N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine and bis(tri-n-butyltin). MSnBG is used in no-carrier-added synthesis of [*I]MIBG. The [*I]MIBG obtained by this method has better effect on neuroblastoma treatment than that obtained by conventional, carrier-added method. | 02-17-2011 |
| 20110087041 | PROCESS FOR PRODUCING URETHANE (METHA)ACRYLATE - An object of the present invention is to provide a process for producing a urethane (meth)acrylate safely with good productivity, and for achieving the object, the invention provides a process for continuously producing a urethane (meth)acrylate, containing causing a mixed liquid of a compound (A) having a hydroxyl group and a (meth)acryloyl group and a compound (B) having an isocyanate group to pass continuously and densely through a tubular microchannel formed in a heat-conducting reaction device, and reacting the hydroxyl group of the compound (A) with the isocyanate group of the compound (B), in which the tubular microchannel in the reaction device has a space size making a fluid cross-sectional area, through which the mixed liquid passes densely, of from 0.1 to 4.0 mm | 04-14-2011 |
| 20110144373 | WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER - Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers. | 06-16-2011 |
| 20110160476 | N-Substituted Carbamic Acid Ester Production Method and Isocyanate Production Method Using the N-Substituted Carbamic Acid Ester - The present invention provides a method for producing N-substituted carbamic acid-O-aryl ester derived from a compound having an ureido group, the method comprising the step of carrying out esterification or esterification and transesterification from the compound having the ureido group and a hydroxy composition containing one type or a plurality of types of hydroxy compounds. | 06-30-2011 |
| 20120149934 | PHOTO-CROSSLINKER - Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof. | 06-14-2012 |
| 20130023691 | METHOD FOR PRODUCING CARBAMATE COMPOUND, CARBAMATE COMPOUND, AND METHOD FOR PRODUCING ISOCYANATE COMPOUND USING SAME - The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group. | 01-24-2013 |
| 20130079542 | PROCESSES FOR PRODUCING ARYL CARBAMATES, ISOCYNATES AND POLYUREAS USING DIARYL CARBONATE - A preparation of aryl carbamates can be achieved readily by carbonylation of an aromatic polyamine compound with diphenyl carbonate (DPC) using a combination of an organic acid and a tertiary amine as a catalyst. Aryl carbamate can be converted into 4,4′-diphenylmethane diisocyanate (MDI) by heating it at about 200 to about 230° C. in a non-polar solvent containing inhibitor such as benzoyl chloride. In another application, trans-ureation of biscarbamates with an amine or mixed amines is found to be extremely facile in a polar solvent such as dimethyl sulfoxide (DMSO) and tetramethylene sulfone (TMS) in absence of any catalyst to make polyurea polymers of high molecular weights. Thus, efficient green-chemistry processes based on biscarbamates in making isocyanate products as well as urea prepolymers, urea elastomers and urea plastics have been developed in all in excellent yields without using reactive phosgene or 4,4′-diphenylmethane diisocyanate separately in the trans-ureation polymerizations. | 03-28-2013 |
| 20130178643 | Isocyanates and Aromatic Hydroxy Compounds - An object of the present invention is to provide a process for producing isocyanates, which are industrially useful compounds, without using phosgene, and to provide a process for chemically recycling waste polycarbonate resin. The present invention discloses a process enabling isocyanate compounds to be produced without using phosgene as a raw material by subjecting a carbamic acid ester compound obtained by a reaction between an aromatic polycarbonate resin and an amine compound to a thermal decomposition reaction, while at the same time disclosing a process enabling chemical recycling of aromatic polycarbonate resin by recovering a divalent aromatic hydroxy compound forming aromatic polycarbonates. | 07-11-2013 |
| 20130231495 | METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES - The invention provides metal carbamates of the general formula (I) | 09-05-2013 |
| 20130274502 | Processes For Preparing A Polymeric Compound - The present invention provides methods for preparing a polymeric compound of Formula I: | 10-17-2013 |
| 20130281727 | METAL CARBAMATES FORMED FROM DIAMINOPHENYLMETHANE - The invention provides metal carbamates of the general formula (I) | 10-24-2013 |
| 20140194644 | N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound - The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less. | 07-10-2014 |
| 20150087854 | METHOD FOR PRODUCING CARBAMATE COMPOUND, CARBAMATE COMPOUND, AND METHOD FOR PRODUCING ISOCYANATE COMPOUND USING SAME - The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group. | 03-26-2015 |
| 20150148559 | PROCESS FOR MAKING AMINO ACID COMPOUNDS - The invention provides new processes for making and purifying amino acid compounds, which are useful in the preparation of AKT inhibitors used in the treatment of diseases such as cancer, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one. | 05-28-2015 |
| 20160046565 | XYLYLENE DICARBAMATE, METHOD FOR PRODUCING XYLYLENE DIISOCYANATE, XYLYLENE DIISOCYANATE, AND METHOD FOR RESERVING XYLYLENE DICARBAMATE - Xylylene dicarbamate contains impurities represented by formulas (1) to (4) below at a ratio of less than 100 ppm as a total amount thereof on a mass basis. | 02-18-2016 |
| 20160194277 | ZINC CLUSTER COMPOUNDS AND THEIR USE AS CATALYSTS IN THE REACTION OF AMINES WITH DIALKYL CARBONATES | 07-07-2016 |
| 560026000 | Polyoxy alcohol moiety | 4 |
| 20080200718 | Novel material forming supramolecular structures, process and uses - The invention relates to novel material, forming supramolecular structures below its transition temperature, which contains at least one C=O and/or C=S group and at least one N—H, O—H and/or S—H group and wherein the material has the structure | 08-21-2008 |
| 20110065949 | COMPOUND FOR SOLID POLYMER ELECTROLYTE MEMBRANE - An unsaturated compound including a urethane bond in a main chain and a sulfonic acid group, a phosphoric acid group, an alkylsulfonic acid group, or an alkylphosphoric acid group on a benzene ring in a side chain is provided. In addition, a solid polymer electrolyte membrane containing a compound prepared by polymerizing the above-mentioned compound and an electrolyte membrane-electrode assembly including diffusion layers adhered on both surfaces of the electrolyte membrane are provided. Furthermore, a solid polymer fuel cell using the electrolyte membrane-electrode assembly is provided. | 03-17-2011 |
| 20110137067 | METHOD FOR PRODUCING URETHANES COMPOSED OF DI-FUNCTIONAL AROMATIC AMINES AND DIALKYL CARBONATES - A process for preparing urethanes by reacting aromatic diamines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 2-18 carbon atoms and one or more heteroatoms and the reaction is performed in the presence of a catalyst. | 06-09-2011 |
| 20160031804 | Augmenting Moieties for Anti-Inflammatory Compounds - Augmented or synergized anti-inflammatory constructs are disclosed including terpenes covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids, amino acids and polyamines; and anti-inflammatory molecules covalently conjugated with specific amino acids. For the latter, further conjugation with a choline bioisostere further augments the anti-inflammatory activity. | 02-04-2016 |
| 560027000 | Plural rings in acid moiety | 12 |
| 20100267982 | HIGH ADHESIVE ACRYLATE MONOMER AND METHOD FOR PREPARING THE SAME - A high adhesive acrylate monomer has a specific chemistry figure. This monomer may be easily prepared in a simplified way, and various linkers may be used between L-DOPA and an acrylate group attached to a tail of L-DOPA, so molecular weight and size of the entire material may be easily controlled. Also, various kinds of acrylate to be combined to a isocyanate compound used as a linker may be selected, so various molecules may be easily composed. | 10-21-2010 |
| 20110144374 | OXIME ETHER DERIVATIVE AND FUNGICIDE FOR AGRICULTURE AND HORTICULTURE - Provided is a fungicide for agriculture and horticulture containing at least one of oxime ether derivative represented by Formula (I) or a salt thereof (wherein X represents a halogen atom, a C1-C20 alkyl group or the like, R | 06-16-2011 |
| 20130041173 | MODIFIED DIAMOND PARTICLES - Modified diamond particles for use in chromatography with a desired functional group at the diamond surface, formed from reaction of hydroxyl groups at diamond surfaces with a reactive molecule. | 02-14-2013 |
| 20130066101 | PROCESS FOR PREPARING BIARYL SUBSTITUTED 4-AMINO BUTYRIC ACID OR DERIVATIVES THEREOF AND THEIR USE IN THE PRODUCTION OF NEP INHIBITORS - The invention relates to a process for producing a compound according to formula (i) | 03-14-2013 |
| 20130158285 | PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE MANUFACTURE OF NEP INHIBITORS - The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof. | 06-20-2013 |
| 20130245307 | PREPARATION OF PET PRECURSOR - The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [ | 09-19-2013 |
| 20140243546 | Processes - The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, | 08-28-2014 |
| 20140296559 | SYNTHESIS OF R-BIPHENYLALANINOL - This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The in vention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds. | 10-02-2014 |
| 20140350285 | NOVEL POLYMORPHS OF N-[2-AMINO-4-(4-FLUOROBENZYLAMINO)-PHENYL] CARBAMIC ACID ETHYL ESTER AND PROCESSES THEREOF - The present invention relates to novel polymorphs of N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, processes for preparing them, and pharmaceutical composition comprising them. In one aspect, the present invention relates to a novel crystalline polymorph of retigabine designated as crystalline Form I, characterized by XRPD having characteristic peaks at about 4.87, 5.04, 7.03, 9.74, 10.02, 11.6, 18.03, 19.9 and 28.5±0.2 degrees two-theta, which is substantially same as depicted in FIG. | 11-27-2014 |
| 20160200665 | SYNTHESIS OF BIPHENYLALANINOL VIA NOVEL INTERMEDIATES | 07-14-2016 |
| 560028000 | Ortho fused | 2 |
| 20110172455 | PROCESS FOR PREPARING CINACALCET AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - The resent invention rovides a novel rocess for re arin cinacalcet of formula I and pharmaceutically acceptable salts thereof and process of purification. The present invention also provides novel nitrogen protected synthetic intermediates useful in the process of the present invention. Further, the present invention provides a novel substituted carbamate impurity and process of preparation thereof. | 07-14-2011 |
| 20110178326 | UNSATURATED CINACALCET SALTS AND PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE - Disclosed herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of cinacalcet hydrochloride. Disclosed also herein are novel hydrochloride, oxalate and di-p-toluoyl-L-(+)-tartrate salts of (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propylene]-1-naphthalenemethaneamine (unsaturated cinacalcet), solid state forms of the salts, and a process for their preparation thereof. | 07-21-2011 |
| 560029000 | Oxy in acid moiety | 9 |
| 20090171112 | UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME - A process for preparing a compound (C) represented by the following formula: | 07-02-2009 |
| 20110152561 | METHOD FOR PRODUCTION OF N-CARBOXY AMINO ACID ANHYDRIDE AND AMINO ACID CARBAMATE COMPOUND - A method for production of an N-carboxy amino acid anhydride with efficiency is provided. The method for production of an N-carboxy amino acid anhydride includes a step of reaction of an amino acid organic salt compound with a carbonic acid diester. | 06-23-2011 |
| 20110319649 | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide - The invention relates to ((R)-1-Benzylcarbamoyl-2-hydroxy-ethyl)-carbamic acid tert-butyl ester (compound III) with an ee of greater than 90%. | 12-29-2011 |
| 20120095251 | Process for Producing Lacosamide - The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20° C. | 04-19-2012 |
| 20120226066 | PROCESSES FOR INTERMEDIATES FOR MACROCYCLIC COMPOUNDS - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 09-06-2012 |
| 20120226067 | PROCESSES FOR INTERMEDIATES FOR MACROCYCLIC COMPOUNDS - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 09-06-2012 |
| 20120283466 | LACOSAMIDE INTERMEDIATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF - A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved. | 11-08-2012 |
| 20130066102 | LACOSAMIDE INTERMEDIATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF - A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved. | 03-14-2013 |
| 20150038733 | METHOD FOR SYNTHESIZING RAMALIN AND RAMALIN PRECURSOR BY USING GLUTAMIC ACID DERIVATIVE AND HYDROXY ANILINE OR HYDROXY ANILINE HAVING PROTECTED HYDROXY GROUP - Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin. | 02-05-2015 |
| 560030000 | Halogen in acid moiety | 7 |
| 20120010425 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF - Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described. | 01-12-2012 |
| 20120123144 | Manufacturing process for sitagliptin from L-aspartic acid - The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as oral anti-diabetic drug. Starting from L-aspartic acid derivate of formula IV the invention describes preparation of the chiral (R)-β-amino acid of formula II known as a precursor in the synthesis of Sitagliptin (formula I). | 05-17-2012 |
| 20160152559 | PROCESS FOR THE PREPARATION OF URETHANES | 06-02-2016 |
| 560031000 | Ring in alcohol moiety | 4 |
| 20100105942 | Process for the Synthesis of Aryloxypropylamine and Heteroaryloxypropylamine - The present invention relates to a process for the synthesis of aryloxypropylamine and heteroaryloxypropylamine of formula I: | 04-29-2010 |
| 20130267729 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE - Disclosed are methods for preparing compounds of Formula 1 and 1A. The first method utilizes a benzyl carbamate amine protecting group and an intermediate of Formula 4. The second method utilizes a tert-butyl carbamate amine protecting group and an intermediate of Formula 7. The third method utilizes a dibenzyl amine protecting group. Also disclosed is a compound, phenylmethyl N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate (a compound of Formula 4). Further disclosed is a method for preparing a compound of Formula 14 from a compound of Formula 15 and a compound of Formula 1 or 1A. | 10-10-2013 |
| 20190144373 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | 05-16-2019 |
| 20190144374 | METHOD FOR PREPARING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE | 05-16-2019 |
| 560032000 | Ring in alcohol moiety | 1 |
| 20130274503 | PROCESS FOR THE MANUFACTURE OF BRIDGED MONOBACTAM INTERMEDIATES - C1-C6Alkyloxy- or benzyloxy-carbonyl esters of -{3-[(E)-(1-phenyl or naphthyl C1-C4alkyl)-imino]-propyl}-amino)-acetic acid, which are intermediates for producing known bridged monobactam compounds useful in the treatment of bacterial infections. | 10-17-2013 |
| 560033000 | Sulfur, nitrogen, halogen or additional oxy in alcohol moiety | 3 |
| 20100286434 | Ethylenically unsaturated monomers for thickener compositions - New ethylenically unsaturated monomers are provided that can be (co)polymerized to provide a composition and method whereby the same group that is attached to or within the backbone of an associative thickener is reversibly switched between being hydrophilic and hydrophobic in nature. When the group that is attached to or within the backbone is rendered hydrophilic, the aqueous thickener is pourable and readily incorporated into aqueous polymer compositions. When this group is rendered hydrophobic, the thickener performs its thickening function efficiently. Switching is readily accomplished by adjusting the pH of the associative thickener composition and the aqueous polymer composition being thickened. The thickeners are prepared from the novel monomers by an aqueous solution polymerization. | 11-11-2010 |
| 20110105782 | Process for the preparation of carbamates of primary and secondary polyamines - A process is described for the preparation of carbamates of primary and/or secondary polyamines, which process comprises the steps of vaporising a primary and/or secondary polyamine and reacting said vaporised primary and/or secondary polyamine with gaseous carbon dioxide. In particular, the process relates to the production of the carbamates of hexamethylenediamine, 1,4-diaminocyclohexane and 3-aminomethyl-3,5,5-trimethylcyclohexylamine. | 05-05-2011 |
| 20120203022 | METHOD FOR PRODUCING URETHANES - The content of the invention is a process for preparing urethanes by reaction of aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in the 2 position, and the reaction is performed in the presence of a substoichiometric amount of base, based on the amino groups. | 08-09-2012 |
