| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 558044000 | Sulfonate esters (i.e., compounds having the sulfonate group, -O-S(=O)(=O) , wherein the single bonded oxygen is bonded directly to carbon, which carbon may be single bonded to any atom but may be multiple bonded only to carbon) | 45 |
| 20080227996 | Sulfonated Amorphous Carbon, Process for Producing the Same and Use Thereof - An amorphous carbon having sulfonate group introduced therein is provided which is characterized in that chemical shifts of a condensed aromatic carbon 6-membered ring and a condensed aromatic carbon 6-membered ring having sulfonate group bonded thereto are detected in a | 09-18-2008 |
| 20090018359 | SYNTHETIC PETROLEUM SULFONATE - A synthetic petroleum sulfonate prepared by a process comprising (a) reacting at least one aromatic compound with a mixture of olefins selected from olefins having from about 8 to about 100 carbon atoms, in the presence of an acidic ionic liquid catalyst, wherein the resulting product comprises at least about 50 weight percent of a 1,2,4 tri-substituted aromatic compound or a 1,2,3 tri-substituted aromatic compound or mixtures thereof; (b) reacting the product of (a) with sulfur trioxide, which has been diluted with air; and (c) neutralizing the product of (b) with an alkali or alkaline earth metal hydroxide. | 01-15-2009 |
| 20110015422 | COMPOUND - To provide a novel compound. | 01-20-2011 |
| 20110028751 | PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS - Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: | 02-03-2011 |
| 20110054207 | SULFATED PSYLLIUM DERIVATIVE FOR REDUCING THE RISK OF CHRONIC HUMAN DISEASES AND METHOD FOR PREPARING THE SAME - The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide, pyridine, dimethylformamide and chlorosulfonic acid in pyridine. Six total sulfated psyllium derivatives named SP1, SP2, SP3, SPR1, SPR2, and SPR3 were prepared and evaluated for their morphological and rheological properties, and bile acid-binding abilities. The invention offers a novel approach to obtaining sulfated psyllium derivatives for use in functional foods or supplemental and pharmaceutical products to increase health benefits. | 03-03-2011 |
| 20130289295 | DIASTEREOSELECTIVE PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS - The present invention relates to a new process for the diastereoselective preparation of (1R*,4R*,5S*,6S*)-6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds, the compounds of the formula (II), which may subsequently be further transformed to 5-aryl-bicyclo[2.2.2]oct-5-en-2-one compounds of the formula (I): | 10-31-2013 |
| 558045000 | Phosphorus attached directly or indirectly to the sulfonate group by nonionic bonding | 2 |
| 20100121091 | Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom - The invention relates to methods of preparing compounds of formula (II) wherein Z represents —OR | 05-13-2010 |
| 20140046085 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof - The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives. | 02-13-2014 |
| 558046000 | Plural sulfonate groups attached indirectly to each other by nonionic bonding | 4 |
| 20100094038 | SYNTHESIS - The present invention provides a method of preparing a sulfonyl ether comprising the steps of: v) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; vi) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage; vii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the sulfonyl ether pre-mix to provide a crude sulfonyl ether product; and viii) purifying the crude sulfonyl ether product. | 04-15-2010 |
| 20120130107 | PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE - Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. | 05-24-2012 |
| 20130096337 | Process for Preparation of Optically Active Compounds using Transfer Hydrogenation - A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate. | 04-18-2013 |
| 20160046551 | VINYL-GROUP-CONTAINING FLUORENE COMPOUND - A novel vinyl-group-containing fluorene compound and a method for producing the same, a polymerizable monomer and cross-linking agent including this compound, a leaving-group-containing fluorene compound, a monovinyl-group-containing fluorene compound, and methods for producing the same. This vinyl-group-containing fluorene compound is represented by formula (1). In the formula, W | 02-18-2016 |
| 558048000 | Nitrogen attached directly or indirectly to the sulfonate group by acyclic nonionic bonding | 6 |
| 20090137831 | Fluorinated Alkanesulfonic Acid Esters and Amides and Processes for Making and Using the Same - The invention provides novel aryl and aliphatic esters of fluorinated alkanesulfonic acids. The invention also provides novel fluorinated alkanesulfonamides and a process to make the same. The invention also provides a process for the arylation of an amine by contacting the amine with an aryl ester of a fluorinated alkanesulfonic acid. | 05-28-2009 |
| 20120022281 | PROCESS FOR PRODUCING (S)-3-[(1-DIMETHYLAMINO)ETHYL] PHENYL-N-ETHYL-N-METHYL-CARBAMATE VIA NOVEL INTERMEDIATES - Disclosed herein are novel intermediates and process for large scale production of (S)-3-[(1-dimethylamino)ethyl]phenyl-N-ethyl-N-methyl-carbamate (rivastigmine) or its pharmaceutically acceptable salts employing the novel intermediates. Further provided are methods for producing the novel intermediates thereof. | 01-26-2012 |
| 20130137890 | PROCESS FOR THE PREPARATION OF TAPENTADOL - Disclosed herein is an improved process for the preparation of 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-I and its pharmaceutically acceptable salt which comprises the reaction of (S)-1-(dimethylamino)-2-methylpentan-3-one of formula VIII with 3-bromo anisole of formula II under Grignard conditions to get the compound (2S, 3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol of formula V followed by activation of the —OH group of the formula V to convert into sulfonate esters of formula IX, which are on reductive deoxygenation to yield (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1-amine of formula VII and demethylation of formula VII to obtain the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-1. | 05-30-2013 |
| 558049000 | The nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen | 3 |
| 20100041911 | Process For The Production Of (Alkoxycarbonylamino)alkyl Sulfonates - There is provided a process for the preparation of a compound of formula I, which process comprises: (a) reaction of a compound of formula II, HO-D-NH | 02-18-2010 |
| 20110137063 | COMPOUNDS AND PROCESSES FOR PRODUCTION OF RADIOPHARMACEUTICALS - The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes. | 06-09-2011 |
| 20120178957 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF - The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following: | 07-12-2012 |
| 558051000 | Chalcogen attached indirectly to the sulfonate group by acyclic nonionic bonding | 6 |
| 20110144370 | Polymerization of Hydroxytyrosol Mediated by Horseradish Peroxidases - The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent. | 06-16-2011 |
| 20120184763 | METHOD FOR PRODUCING PERFLUOROSULFONIC ACID HAVING ETHER STRUCTURE AND DERIVATIVE THEREOF, AND SURFACTANT CONTAINING FLUORINE-CONTAINING ETHER SULFONIC ACID COMPOUND AND DERIVATIVE THEREOF - In this method, R | 07-19-2012 |
| 20140012032 | METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGANDS - This invention relates to methods, which provide access to F-18 labeled stilbene derivatives. | 01-09-2014 |
| 558052000 | The chalcogen, X, is in a -C(=X)- group | 3 |
| 20100016623 | PROCESS FOR REGIOSELECTIVE MONO-TOSYLATION OF DIOLS - The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for regioselective diol mono-tosylat ion, wherein Y is selected from the group of C | 01-21-2010 |
| 20110207954 | Method for Producing Alkoxycarbonylfluoroalkanesulfonic Acid Salt - In the present invention, a target alkoxycarbonylfluoroalkanesulfonic acid salt is obtained by using a halofluoroalkanoic acid ester as a starting raw material, sulfinating the halofluoroalkanoic acid ester in the presence of an amine (as a first step), and then, oxidizing the resulting sulfination product (as a second step). Further, an alkoxycarbonylfluoroalkanesulfinic acid onium salt, which is useful as a photoacid generator, is obtained by salt exchange reaction of the alkoxycarbonylfluoroalkanesulfonic acid salt. | 08-25-2011 |
| 20120029223 | METHOD FOR PRODUCTION OF SUBSTITUTED ALKYL MALONIC ESTERS AND DERIVATIVES THEREOF - Substituted alkyl methyl malonate compounds are produced in an essentially one step method, the method suitable for large scale production of alkyl malonate compounds. According to one embodiment the method comprises reacting a methyl malonate with a di-functional, doubly tosylated, alkyl chain. | 02-02-2012 |
| 558053000 | Halogen attached directly or indirectly to the sulfonate group by acyclic nonionic bonding | 9 |
| 20110040115 | INTERMEDIATES AND PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE - Process for the preparation of aromatic derivatives of 1-adamantane (tricyclo[3.3.1.1 (3,7)]decane), or an acceptable pharmaceutical salt thereof, based on a hydrolysis reaction of a precursor cyano compound. It also comprises different processes for obtaining the cyano compound. It is especially useful for obtaining Adapalene on an industrial scale in high yield and purity. It also comprises new intermediates useful in said preparation process. | 02-17-2011 |
| 20130211120 | USE OF AN ACETIC ACID WASH TO PREPARE LOW-SULFATE 5-SULFOISOPHTHALIC ACID, MONO-LITHIUM SALT - There is disclosed a process for making a mono-lithium salt of 5-sulfoisophthalic acid (LiSIPA) having less than 500 ppm sulfate. The process uses a reaction mixture of water, a lithium cation producing compound, and 5-sulfoisophthalic acid. The reaction mixture is heated to reflux, cooled, filtered and washed with acetic acid to obtain a high quality LiSIPA having less than 500 ppm sulfate. Also disclosed is a high quality, non-purified reaction product containing a mono-lithium salt of 5-sulfoisophthalic acid and having less than 500 ppm sulfate. | 08-15-2013 |
| 20160176807 | An Improved Synthesis of [18F]-fluoroalkyl tosylate | 06-23-2016 |
| 558054000 | Plural halogens attached indirectly to the sulfonate group by acyclic bonding | 6 |
| 20100016624 | AQUEOUS METHODS FOR MAKING FLUORINATED SULFONATE ESTERS - Methods of making a fluorinated sulfonate ester include combining a perfluoroalkanesulfonyl halide and a fluorinated alcohol in water in the presence of hydroxide ion, and recovering at least a portion of the resultant fluorinated sulfonate ester. | 01-21-2010 |
| 20100286430 | METHOD FOR THE SYNTHESIS OF (Z)-3-[2-BUTOXY-3'-(3-HEPTYL-1-METHYL-UREIDO)-BIPHENYL-4-YL]-2-METHOXY-AC- RYLIC ACID - The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): | 11-11-2010 |
| 20100305352 | METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ALPHA ALKYL CARBONYL COMPOUNDS - A method for the production of optically active α-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the α-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active α-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield. | 12-02-2010 |
| 20110046406 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF - The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)-N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-(S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors. | 02-24-2011 |
| 20110112320 | Manufacture of Hydrofluoroalkanesulfonic Acids - A process for manufacture of hydrofluoroalkanesulfonic acid with at least one hydrogen bonded to the carbon atom adjacent to the carbon atom bonded to the sulfonic acid group comprising: contacting a fluoroolefin with sulfite in an aqueous solution adjusted to about pH 4 to pH 12; removing water from the solution to form a solid; directly treating the solid with oleum; and distilling the hydrofluoroalkanesulfonic acid therefrom. Also a process for manufacture of potassium hydrofluoroalkanesulfonate in high purity is described. | 05-12-2011 |
| 20130217908 | STABILISATION OF RADIOPHARMACEUTICAL PRECURSORS - The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes compositions comprising a radiopharmaceutical precursor and a drying agent, and cassettes for automated synthesis apparatus comprising the same. | 08-22-2013 |
| 558055000 | Acyclic carbon chain containing carbon to carbon unsaturation attached directly to the sulfonate group by nonionic bonding | 4 |
| 20090023941 | METHOD FOR PRODUCING 2-ISOPROPENYL-5-METHYL-4-HEXEN-1-YL 3-METHYL-2-BUTENOATE - The present invention provides a method of producing 2-isopropenyl-5-methyl-4-hexen-1-yl 3-methyl-2-butenoate industrially advantageously in a high yield. More particularly, the present invention provides a method of producing 2-isopropenyl-5-methyl-4-hexen-1-yl 3-methyl-2-butenoate represented by the following formula (IV): | 01-22-2009 |
| 20090112014 | ISOMERIZED ALPHA OLEFIN SULFONATE AND METHOD OF MAKING THE SAME - The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C | 04-30-2009 |
| 20100197950 | PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES - The preparation of an intermediate, a process for the preparation thereof and the process of preparing [4-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-2-methyl-phenoxy]-acetic acid using this intermediate are described. | 08-05-2010 |
| 20150073168 | PROCESS FOR PREPARING AN INTERNAL OLEFIN SULFONATE - The invention relates to a process for preparing an internal olefin sulfonate, comprising sulfonating an internal olefin, having an average carbon number that is equal to or greater than 20, in a sulfonation reactor into sulfonated internal olefin followed by contacting sulfonated internal olefin with a base containing solution, wherein the sulfonation reactor is cooled with a cooling means having a temperature which is greater than 35° C. Further, the invention relates to an internal olefin sulfonate obtainable by said process, and to use of internal olefin sulfonates obtainable or obtained by said process as a surfactant, suitably as a surfactant in chemical Enhanced Oil Recovery. | 03-12-2015 |
| 558056000 | Benzene ring bonded directly to the sulfonate group | 8 |
| 20080221347 | Nucleophile Leaving Groups - Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity. | 09-11-2008 |
| 20090209778 | METHOD OF MAKING A SYNTHETIC ALKYLARYL SULFONATE - A synthetic petroleum sulfonate prepared by a process comprising (a) reacting a first amount of at least one aromatic compound with a first amount of a mixture of olefins having from about 8 to about 100 carbon atoms, in the presence of a strong acid catalyst; (b) reacting the product of (a) with an additional amount of at least one aromatic compound and an additional amount of strong acid catalyst and, optionally, with an additional amount of a mixture of olefins selected from olefins having from about 8 to about 100 carbon atoms, in the presence of a strong acid catalyst, wherein the resulting product comprises at least about 80 weight percent of a 1,2,4-trialkylsubstituted aromatic compound; (c) sulfonating the product of (b); and (c) neutralizing the product of (b) with an alkali or alkaline earth, metal hydroxide or ammonia. | 08-20-2009 |
| 20100240919 | Process For Obtaining Valine Derivatives Useful For Obtaining A Pharmaceutically Active Compound - The invention provides a method for obtaining the intermediate (II), useful for manufacturing Valsartan and a drug directed to a treatment of arterial hypertension or heart failure. The process comprises a) Imination of the aldehyde group of a compound (VII) by L-Valine (IV) salts with organic or inorganic bases and a polar solvent or water, where X means halogen or an —OSO2R group, where R is CF3, tolyl, methyl or F; to give an imine-type compound (VIII), where B+ is the protonated form of an organic base or an alkaline cation; b) Reduction of the imine group of the compound (VIII) followed by acidification, to give the compound (VI); and c) N-Acylation of the compound (VI) with valeryl chloride to give the compound (II). Steps a) and b) can be performed in a “one pot” reaction. | 09-23-2010 |
| 20130066097 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF - A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl. | 03-14-2013 |
| 20130197256 | METHOD FOR THE PREPARATION OF GRAPHENE - A method for the preparation of graphene is provided, which includes: (a) oxidizing a graphite material to form graphite oxide; (b) dispersing graphite oxide into water to form an aqueous suspension of graphite oxide; (c) adding a dispersing agent to the aqueous suspension of graphite oxide; and (d) adding an acidic reducing agent to the aqueous suspension of graphite oxide, wherein graphite oxide is reduced to graphene by the acidic reducing agent, and graphene is further bonded with the dispersing agent to form a graphene dispersion containing a surface-modified graphene. The present invention provides a method for the preparation of graphene using an acidic reducing agent. The obtained graphene can be homogeneously dispersed in water, an acidic solution, a basic solution, or an organic solution. | 08-01-2013 |
| 20170233318 | THE OPTIMIZATION OF O-SULFONATED PHENOL PRODUCTION FOR CUMENE HYDROPEROXIDE CLEAVAGE | 08-17-2017 |
| 558058000 | Additional benzene ring containing | 2 |
| 20130190522 | PROCESS FOR PREPARING L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVE - Provided is a process for the preparing 1-phenyl-3-dimethylaminopropane derivatives of formula I, (The formula should be inserted here) and its pharmaceutically acceptable salts thereof via novel intermediates. | 07-25-2013 |
| 20130289296 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF - A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a) | 10-31-2013 |
