| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 552653000 | 9,10-Seco-cyclopentanohydrophenanthrene ring system or 9,10-seco cyclopentanohydrophenanthrene ring system having a bond between the 3- and 5-positions (e.g., vitamin D compounds, cholecalciferols, activated 7-dehydrocholesterols, dihydrotachysterols, 3,5 cyclovitamin D compounds, etc.) | 28 |
| 20080255380 | Process and Intermediates for the Preparation of Sulfonyl Derivatives of Cholecalciferol - Preparation of sulfonyl derivatives of cholecalciferol of Formula 1, wherein R | 10-16-2008 |
| 20090124819 | 2-SUBSTITUTED VITAMIN D DERIVATIVES - The object of the present invention is to synthesize novel vitamin D derivatives. | 05-14-2009 |
| 20090137828 | Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol - The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings. | 05-28-2009 |
| 20090177002 | Method For Preparing Indene Derivatives, And Intermediates For Preparation Of Derivatives - Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D | 07-09-2009 |
| 20090275768 | Preparation of Paricalcitol - This invention relates to a method for purifying Paricalcitol by reverse phase chromatography. This invention also relates to a purified Paricalcitol prepared by said method. This invention further relates to a method for purifying Paricalcitol by crystallization. | 11-05-2009 |
| 20090281340 | 1ALPHA-HYDROXY-2-(3'-HYDROXYPROPYLIDENE)-19-NOR-VITAMIN D COMPOUNDS AND METHODS OF MAKING AND TREATMENT THEREOF - Disclosed are 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds, pharmaceutical compositions, and methods of making and treatment thereof. The compounds are generally directed to biologically active 2-alkylidene-19-nor-vitamin D compounds and analogs thereof characterized by the presence of a 3′-hydroxypropylidene moiety at C-2 and the presence of an abbreviated alkyl side-chain free of any hydroxyl moiety. | 11-12-2009 |
| 20090318722 | PROCESS FOR PREPARATION OF PARICALCITOL INTERMEDIATES - The present invention relates to a compound and a novel process for the preparation of Paricalcitol intermediates. | 12-24-2009 |
| 20100063307 | PARICALCITOL PURIFICATION - Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying. Isopropyl acetate appears to be unique among commonly available and pharmaceutically acceptable solvents in its ability to precipitate paricalcitol in this high purity, essentially free of isomers thereof. In addition, paricalcitol of purity of at least 99.9% has been shown to have exceptional storage stability. | 03-11-2010 |
| 20110137058 | PREPARATION OF PARICALCITOL - This invention relates to a method for purifying Paricalcitol by reverse phase chromatography. This invention also relates to a purified Paricalcitol prepared by said method. This invention further relates to a method for purifying Paricalcitol by crystallization. | 06-09-2011 |
| 20110184198 | New Process for Isomerizing Fused Bicyclic Structures and Preparation of Vitamin D Analogs Comprising the Same - The present invention concerns a process of isomerizing trans fused bicyclic derivatives into cis fused bicyclic derivatives and the preparation of vitamin D or analogs thereof comprising said isomerisation step. | 07-28-2011 |
| 20110184199 | Methods For Producing Paricalcitol - The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates. | 07-28-2011 |
| 20110213168 | DEUTERATED VITAMIN D COMPOUNDS - The invention relates to deuterated vitamin D compounds and the process for preparing and synthesizing a class of vitamin D compounds which can be isotopically substituted. These compounds can be used as internal standards in methods for the quantification of vitamin D, its metabolites and analogues by mass spectrometry. These compounds are described by means of general formula I. | 09-01-2011 |
| 20110319644 | PROCESS FOR PRODUCTION OF 1-HYDROXY-19-NORCYCLOVITAMIN D DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION - A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production. | 12-29-2011 |
| 20120083614 | (20R,25S)-2-Methylene-19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 in Crystalline Form - A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D | 04-05-2012 |
| 20120289723 | METHOD FOR PREPARING INDENE DERIVATIVES, AND INTERMEDIATES FOR PREPARATION OF DERIVATIVES - Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D | 11-15-2012 |
| 20130006003 | NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES - The present invention discloses the synthone of Formula (I), wherein R | 01-03-2013 |
| 20130023681 | STABILIZED DOXERCALCIFEROL AND PROCESS FOR MANUFACTURING THE SAME - 1 a-hydroxy vitamin D | 01-24-2013 |
| 20130053587 | Crystallization of 1alpha-Hydroxy-20-Methyl-2-Methylene-19,24,25,26,27-Pentanorvitamin D3 - A method of purifying 1α-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvitamin D | 02-28-2013 |
| 20130090486 | Crystallization of 1alpha-Hydroxy-2-Methylene-18,19-Dinor-Homopregnacalciferol - A method of purifying 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol to obtain 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol in crystalline form using precipitation with hexane from ethyl acetate. A method of preparing 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol crystals acceptable for X-ray experiment using precipitation with hexane from benzene by diffusive exchange of the solvents is also described. | 04-11-2013 |
| 20130150598 | USE OF 25-HYDROXY-VITAMIN D3 TO AFFECT HUMAN MUSCLE PHYSIOLOGY - The use of 25-OH D3 (calcifediol) to increase muscle strength, muscle function, or both is provided. Vitamin D3 (cholecalciferol) may optionally be used together with 25-OH D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed. | 06-13-2013 |
| 20130172588 | CONTINUOUS PHOTOLYTIC PROCESS FOR THE PREPARATION OF VITAMIN D RELATED SUBSTANCES - The present application provides a novel method for generation of a vitamin D2 compound using a continuous flow photoisomerization reactor. A compound represented by formula I: [structure] as further defined herein, is mixed with a solvent and a sensitizer, and is then passed through the continuous flow photoisomerization reactor. If X3 and X4 of formula II is tert-butyldimethylsilyl, then formula II is mixed with a deprotection reagent to obtain the vitamin D2 analog. | 07-04-2013 |
| 20130324749 | Crystallization of (20R) and (20S) Analogs of 2-Methylene-19-Nor-24-Dimethyl-1alpha,25-Dihydroxyvitamin D3 - Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D | 12-05-2013 |
| 20130324750 | Crystallization of (20R)-2-Methylene-19-Nor-24-Difluoro-1alpha,25-Dihydroxyvitamin D3 - Disclosed are methods of purifying the compound (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D | 12-05-2013 |
| 20130324751 | Crystallization of (20R) 19-Nor-24-Difluoro-1alpha,25-Dihydroxyvitamin D3 - Disclosed are methods of purifying the compound (20R)-19-nor-24-difluoro-1α,25-dihydroxyvitamin D | 12-05-2013 |
| 20130324752 | Crystallization of (20R,22R)-2-Methylene-19-Nor-22-Methyl-1alpha,25-Dihydroxyvitamin D3 and Related Precursors - Disclosed are methods of purifying the compound (20R,22R)-2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D | 12-05-2013 |
| 20140051875 | CRYSTALLINE FORM OF MAXACALCITOL - The present invention relates to maxacalcitol hydrate, a new crystalline form of maxacalcitol, with superior technical properties e.g. in the manufacture of crystal suspension formulations, and with superior stability properties. | 02-20-2014 |
| 20150148552 | 23-YNE-VITAMIN D3 DERIVATIVE - To provide a novel vitamin D | 05-28-2015 |
| 20150344421 | Versatile and Functionalised Intermediates for the Synthesis of Vitamin D and Novel Vitamin D Derivatives - Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided. | 12-03-2015 |
