| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 549468000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the hetero ring | 31 |
| 20080281111 | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid - Provided are processes for the preparation of mycophenolate mofetil and other esters of mycophenolic acid. | 11-13-2008 |
| 20100036139 | PROCESS FOR THE PREPARATION OF BENZOFURAN-2-CARBOXAMIDES - The invention relates to a process for the preparation of benzofuran-2-carboxamides of the formula (I), in which R | 02-11-2010 |
| 20110178314 | PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS - The present invention relates to a process for the preparation of a compound of formula | 07-21-2011 |
| 20120065411 | PROCESS FOR THE PRODUCTION OF BENZOFURANS - A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided. | 03-15-2012 |
| 20120077995 | PROCESS FOR THE PRODUCTION OF DRONEDARONE INTERMEDIATES - A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone. | 03-29-2012 |
| 20120108828 | SYNTHESIS OF DRONEDARONE AND SALTS THEREOF - The present invention relates to a process for preparation of Dronedarone or pharmaceutically acceptable salts thereof. More particularly, the present invention provides a process for preparation of Dronedarone hydrochloride, without the isolation of Dronedarone base. | 05-03-2012 |
| 20120289717 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE - The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: | 11-15-2012 |
| 20120330036 | Process for the preparation of dronedarone - The subject of the present disclosure is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: | 12-27-2012 |
| 20120330037 | NOVEL PROCESS FOR THE MANUFACTURE OF DRONEDARONE - The invention relates to a new process for the preparation of dronedarone and its salts, in particular a synthesis process which allows said compound and its salts to be obtained with good yields, high purity and in an industrially expedient manner; the invention also concerns a new synthesis intermediate. | 12-27-2012 |
| 20130012729 | KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES - The present disclosure relates to ketobenzofuran derivatives of the general formula (I): | 01-10-2013 |
| 20130023677 | PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES - This disclosure relates to a process for preparing 5-aminobenzofuran derivatives of general formula (I): | 01-24-2013 |
| 20130046103 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES - The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention. | 02-21-2013 |
| 20130072697 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS - A process is provided for preparing dronedarone or pharmaceutically acceptable salts thereof. The process comprises reacting 5-amino-2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)benzofuran (compound A) with methanesulfonyl chloride without any catalyst to provide crude dronedarone hydrochloride, which is purified to afford highly pure product. Then, the dronedarone hydrochloride can be converted to highly pure dronedarone through treatment with an alkaline solvent, the dronedarone can be further converted to other pharmaceutically acceptable salts of dronedarone. In this process, acylation between compound A and methanesulfonyl chloride is carried out successfully and the formation of the dimethylsulfonyl by-product is inhibited. | 03-21-2013 |
| 20130109868 | Process for the Preparation of Dronedarone | 05-02-2013 |
| 20130131358 | Novel Process for the Preparation of Dronedarone - The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)-propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula I: | 05-23-2013 |
| 20130165673 | METHOD FOR PREPARING 3-KETO-BENZOFURANE DERIVATIVES - The invention relates to a method for preparing 3-keto-benzofurane derivatives of the general formula: Formula (I), where R is an alkyl or aryl group, R | 06-27-2013 |
| 20130165674 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 - The disclosure relates to a process for preparing benzofuran derivatives of general formula I: | 06-27-2013 |
| 20130165675 | PROCESS FOR PREPARING AMINOBENZOYLBENZOFURAN DERIVATIVES - The disclosure relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula I: | 06-27-2013 |
| 20130261321 | PROCESS FOR THE PREPARATION OF DRONEDARONE - The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: | 10-03-2013 |
| 20130289287 | PROCESS FOR OBTAINING DRONEDARONE - The present invention provides a process for obtaining dronedarone or salts thereof characterized in that in an organic phase comprising one or more non-polar solvents, 5-amino-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-2-n-butyl-benzofuran is reacted with methane sulfonyl chloride without the addition of a base. The invention also provides a process for obtaining intermediates of dronedarone environmentally friendly and industrially viable. | 10-31-2013 |
| 20140018554 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND - The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof. | 01-16-2014 |
| 20140046078 | PROCESS FOR SYNTHESIZING KETO BENZOFURAN DERIVATIVES - The invention relates to a method for synthesizing benzofuran derivatives, in particular the dronedarone of formula (D), including carrying out a Fries rearrangement reaction using a sulfonamido-benzofuran ester intermediate. | 02-13-2014 |
| 20140081035 | PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION - The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-1-benzofuran-3-yl) {4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II)—where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid—is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone. | 03-20-2014 |
| 20140114081 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION - The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH | 04-24-2014 |
| 20150018568 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT - The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II)—where L is leaving group—is reacted with compound of formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. | 01-15-2015 |
| 20150031902 | PROCESS FOR THE PREPARATION OF DRONEDARONE BY OXIDATION OF A SULPHENYL GROUP - The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof. | 01-29-2015 |
| 20150065734 | PROCESS FOR PREPARING DRONEDARONE AND SALTS THEREOF - The present disclosure relates to processes for preparing dronedarone or pharmaceutically acceptable salts thereof. | 03-05-2015 |
| 20160009678 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | 01-14-2016 |
| 20160009679 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | 01-14-2016 |
| 20160075673 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT - The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II)—where L is leaving group—is reacted with compound of formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. | 03-17-2016 |
| 20160075674 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP - The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. | 03-17-2016 |
