| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 549467000 | Nitrogen attached directly or indirectly to the hetero ring by acyclic nonionic bonding | 17 |
| 20080281110 | Process for resolving citalopram - The (S)-citalopram content of a mixture of (R)- and (S)-citalopram can be enriched by using L-tartaric acid as the resolving agent in the presence of formaldehyde. | 11-13-2008 |
| 20090018351 | PREPARATION OF ESCITALOPRAM - The present invention relates to a process for preparing enantiomerically enriched citalopram via methylating enantiomerically enriched didesmethylcitalopram, which is prepared by directly resolving racemic didesmethylcitalopram using a chiral acid. | 01-15-2009 |
| 20090069582 | METHOD FOR MANUFACTURE OF ESCITALOPRAM - This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallizing 4-[4-(dimethylamino)-1-(4′-fluoro-phenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)—(S,S)— or (−)—(R,R)-enantiomer of O,O′-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile. | 03-12-2009 |
| 20090099375 | process for the preparation of escitalopram - The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers. | 04-16-2009 |
| 20090281336 | BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES - The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus. | 11-12-2009 |
| 20090326249 | Process for Preparation of Citalopram and Enantiomers - The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 12-31-2009 |
| 20100087664 | PREPARATION OF CITALOPRAM AND SALTS THEREOF - Process for the preparation of citalopram and its salts, comprising reacting magnesium (5-cyano-2-(4-fluorobenzoyl)phenyl)methanolate bromide with 3-N,N-dimethylaminopropyl magnesium halide in a mixture of solvents, obtaining a diol intermediate in the form of its acid addition salt, and reacting the acid addition salt with sulfuric acid in an aqueous medium. | 04-08-2010 |
| 20100204493 | Process for the Preparation of Escitalopram - The present invention provides a novel process for the preparation of a compound of Formula III, and novel processes for preparing escitalopram using the compound of Formula III. | 08-12-2010 |
| 20100249437 | PROCESS FOR PREPARATION OF CITALOPRAM AND ENANTIOMERS - The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 09-30-2010 |
| 20110009648 | Carbonyl Asymmetric Alkylation - This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis. | 01-13-2011 |
| 20110065937 | METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM - The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation. | 03-17-2011 |
| 20110065938 | METHOD FOR THE PREPARATION OF ESCITALOPRAM - A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided. | 03-17-2011 |
| 20110092719 | Preparation of Escitalopram, Its Salts and Intermediates - The present patent application relates to an improved process for the preparation of escitalopram, its salts and intermediates. It also relates to a novel crystalline form S of citalopram diol intermediate, process for preparation and its use in the preparation of citalopram, escitalopram and their salts. | 04-21-2011 |
| 20110130576 | PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)-2-PHTHALIMIDOMETHYLCYCLOPROPANE - The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, and reacting the reaction product with a phthalimidating agent; and a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane hydrochloride through the above process. | 06-02-2011 |
| 20110251410 | PROCESS FOR PREPARATION OF CITALOPRAM AND ENANTIOMERS - The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran car-bonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, | 10-13-2011 |
| 20130211107 | PROCESS FOR THE PURIFICATION OF PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram. | 08-15-2013 |
| 20150031901 | METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES - The invention relates to a method for preparing 5-amino-benzoyl-benzofuran derivatives having the general formula in which R | 01-29-2015 |
