Class / Patent application number | Description | Number of patent applications / Date published |
549458000 | Tricyclo ring system having the hetero ring as one of the cyclos | 30 |
20080242877 | Intermediates and processes for the synthesis of Ramelteon - Provided are intermediates and processes for preparation of Ramelteon. | 10-02-2008 |
20080300415 | Preparation of optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities - An object of the present invention is to provide a method for efficiently preparing (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]-furan-4,9-dione useful as a medicine at a low cost and in large amounts. According to the present invention, the desired (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione can be prepared with high efficiency at a low cost and in large amounts by asymmetrically reducing 2-acetyl-5-hydroxynaphtho[2,3-b]furan-4,9-dione in the presence of an asymmetric ruthenium complex and a hydrogen donor. | 12-04-2008 |
20090069581 | PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES - The present invention provides processes and intermediates for the synthesis of ramelteon. | 03-12-2009 |
20090105490 | Polymorphic forms of ramelteon and processes for preparation thereof - An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention. | 04-23-2009 |
20100105931 | BIS(TETRAHYDROFURAN) COMPOUND, METHOD FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND - The present invention provides a new bis(tetrahydrofuran) compound having an excellent neurotrophic factor activity-enhancing effect, and a process for producing the same. The bis(tetrahydrofuran) compound of the present invention is represented by formula (1): | 04-29-2010 |
20100152467 | METHOD FOR PRODUCING CERCOSPORAMIDE - The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus | 06-17-2010 |
20100152468 | PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES - The present invention provides processes and intermediates for the synthesis of ramelteon. | 06-17-2010 |
20100234622 | PROCESS FOR THE PREPARATION OF RAMELTEON - A process is described for the preparation on an industrial scale of N-[2-(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propionamide, ramelteon, having the structure illustrated below: | 09-16-2010 |
20100311990 | PROCESS FOR THE PREPARATION OF TETRANORLABDANE DERIVATIVES - The present invention concerns a process for the preparation of a compound of formula (I), wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof. | 12-09-2010 |
20100324313 | METHOD FOR THE PURIFICATION OF PROSTAGLANDINS - The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method. | 12-23-2010 |
20110207949 | PROCESS FOR THE PREPARATION OF RAMELTEON - Disclosed herein is a process for resolving N-[2-(1,6,7,8-tetrahydro-2H-indeno [5,4-b] furan-8-yl)] ethylamine into its isomers using an optically active acid and a process for preparing ramelteon from the resolved isomer. | 08-25-2011 |
20110218347 | PROCESS FOR THE PREPARATION OF TETRANORLABDANE DERIVATIVES - The present invention concerns a process for the preparation of a compound of formula (I) wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof. | 09-08-2011 |
20110319642 | PROCESS FOR PRODUCING (.+-.)-3a,6,6,9a-TETRAMETHYL DODECAHYDRONAPHTHO[2,1-b]FURANS - The present invention relates to a process for producing (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans from crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans obtained by subjecting (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furan-2(1H)-ones which are produced by cyclizing a homofarnesylic acid amide or a monocyclohomofarnesylic acid amide in the presence of an acid agent and then hydrolyzing the cyclized product, to reduction reaction and then to cyclization reaction, said process including (i) an alkali treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans are heated in the presence of an alcohol and a metal hydroxide; and (ii) a washing treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans are washed with an aqueous acid solution. The thus obtained (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans have a less off-odor and hardly suffer from deterioration of their smell during storage. | 12-29-2011 |
20120071673 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMI- DE - The present invention relates in general to the field of organic chemistry and in particular to the preparation of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon, and analogues thereof. | 03-22-2012 |
20120271059 | Organic Compounds - A process for the preparation of β,γ-unsaturated-γ,γ-disubstituted esters 1 with high E/Z- and β,γ/α,β-ratios, Formula (1) by reacting at a temperature of between about 130 and 170 degrees centigrade the conjugated malonate Formula (3) with, a group I, II or III metal halide or an organic cation/halide anion pair, an inorganic proton source and a polar solvent. | 10-25-2012 |
20120323025 | METHOD OF PRODUCING BERAPROST - An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. | 12-20-2012 |
20130060052 | ORALLY DISPERSIBLE TABLET - The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture. | 03-07-2013 |
20140235879 | ORALLY DISPERSIBLE TABLET - The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture. | 08-21-2014 |
20140275578 | 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE - Compounds of the formula 1 | 09-18-2014 |
20150025255 | PROCESS FOR PREPARING SYNTHETIC PROSTACYCLINS - The presently disclosed subject matter provides methods of preparing synthetic prostacyclin analogues, including Beraprost, either as racemic mixtures or as single stereoisomers. Also provided are novel synthetic intermediates for use in these methods. | 01-22-2015 |
20150094476 | 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE - Compounds of the formula 1 | 04-02-2015 |
20160002192 | 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE - Compounds of the formula 1 | 01-07-2016 |
20160046593 | Preparation of Ambrox from Labdanes of Dysoxylum hongkongense, and the Preparation of New Diterpenoids from Dysoxylum hongkongense - The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of | 02-18-2016 |
20160168109 | METHOD FOR PRODUCING N,N-DIALKYLHOMOFARNESIC ACID AMIDE | 06-16-2016 |
20160200648 | PROCESS FOR THE PREPARATION OF (3E, 7E)-HOMOFARNESOL | 07-14-2016 |
549459000 | Two of the cyclos share at least three ring members (i.e., bridged) | 3 |
20090247772 | Method for the Preparation of Escitalopram - The invention relates to intermediates and the use thereof in a method for the preparation of escitalopram: | 10-01-2009 |
20110028743 | POLYCYCLIC ESTER CONTAINING CYANO GROUP AND LACTONE SKELETON - A polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): | 02-03-2011 |
20140187801 | ASYMETRIC SYNTHESIS OF NORCANTHARIDIN ANALOUGUS BY ALKYNYLATION OF OXABENZONORBORNADIENES AND THEIR ANTICANCER ACTIVITIES - The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors. | 07-03-2014 |
549460000 | Dibenzofurans (including hydrogenated) | 2 |
20120184755 | Stilbene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device - An object is to provide a novel stilbene compound suitable for an organic EL light-emitting material. Provided is a novel stilbene compound represented by a general formula (G1) below. In the formula, Q | 07-19-2012 |
20160133849 | MATERIAL FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME - A novel and improved material for an organic electroluminescent device includes at least one monoamine compound represented by any one of the following Formulae I to III: | 05-12-2016 |