Class / Patent application number | Description | Number of patent applications / Date published |
549321000 | Nitrogen attached directly or indirectly to the lactone ring by acyclic nonionic bonding | 6 |
20120165555 | RING OPENING OF LACTONES AND LACTAMS - The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof. | 06-28-2012 |
20120296100 | Manufacturing process for 8-aryloctanoic acids such as Aliskiren - The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compound such as Aliskiren. | 11-22-2012 |
20130012728 | N-ACYLATION OF AMINES - Provided herein are processes for the preparation of N-acylated amines. In particular, the processes comprise contacting an amine with an acid comprising a carboxylic acid group to form the N-acylated amine. | 01-10-2013 |
20130184474 | METHOD FOR PREPARING AN AMINO ACID FROM 2 AMINOBUTYROLACTONE - The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCH | 07-18-2013 |
20130225841 | METHOD FOR PREPARING ALISKIREN AND ITS INTERMEDIATES THEREOF - A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R | 08-29-2013 |
20130310577 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN - Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). | 11-21-2013 |