| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 549297000 | Polycyclo ring system having the lactone ring as one of the cyclos | 44 |
| 20080269509 | Oxidation of Alcohol with Use of Hydrogen Peroxide and Tungsten Catalyst - Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst. | 10-30-2008 |
| 20090171103 | Triptolide Derivatives for Modulation of Apoptosis and Immunosuppression - Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents. | 07-02-2009 |
| 20100331554 | TRIPTOLIDE LACTONE RING DERIVATIVES AS IMMUNOMODULATORS AND ANTICANCER AGENTS - Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy. | 12-30-2010 |
| 20110263876 | EXPEDITIOUS SYNTHESIS OF GIBBERLLIN A5 AND ESTERS THEREOF - An expeditious synthesis of gibberellin A | 10-27-2011 |
| 549298000 | Tetracyclo ring system having the lactone ring as one of the cyclos | 5 |
| 20100280263 | Process for the Synthesis of Anticancer (Poly) Aminoalkylaminoacetamide Derivatives of Epipodophyllotoxin - The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-containing reactant, whose amine functions are not protected, with β-chloroacetamido-4′-epipodophyllotoxin in a polar aprotic organic solvent. | 11-04-2010 |
| 20110021791 | Method for preparing 4B-amino-4'-demethyl-4-desoxypodophyllotoxin - The invention relates to a method for synthesizing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4β-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4β-amino-4′-demethyl-4-desoxypodophyllotoxin. | 01-27-2011 |
| 20110213165 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF - The present invention provides novel β-amino podophyllotoxin congeners of general formula (A); R═CH | 09-01-2011 |
| 20120022273 | PROCESS FOR THE PREPARATION OF (POLY) AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN USEFUL FOR THEIR APPLICATIONS IN THERAPEUTICS AS ANTICANCER AGENT - The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterised in that it comprises a step of peptide coupling of 4-amino-4′-demethylepipodophyllotoxin with an amine-containing reactant having protecting groups. | 01-26-2012 |
| 20130245285 | New Process for Preparing Cyclolignans - The invention relates to a one-pot reaction for the preparation of a compound of Formula (I). The compound of Formula (I) may be further transformed into picropodophyllin and derivatives thereof. | 09-19-2013 |
| 549299000 | Tricyclo ring system having the lactone ring as one of the cyclos | 16 |
| 20090203925 | SYNTHESIS OF HIMBACINE ANALOGS - The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. | 08-13-2009 |
| 20090270639 | PROCESS FOR PRODUCTION OF (.+-.)-3A,6,6,9A- TETRAMETHYLDECAHYDRONAPHTHO[2,1-B]FURAN-2(1H)-ONE - The present invention relates to industrially useful production processes in which (±)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-ones and further (±)-3a,6,6,9a-tetramethyldo decahydronaphtho[2,1-b]furans are produced from raw materials which are readily available at low costs, through short steps and in a simple manner. The process for producing (±)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-ones represented by the general formula (III): | 10-29-2009 |
| 20100056807 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 03-04-2010 |
| 20100056808 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 03-04-2010 |
| 20110112312 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane-4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 05-12-2011 |
| 20110184192 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 07-28-2011 |
| 20130012727 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF - The present invention provides a method for preparing Cleistanthin A, a diphyllin glycoside, derivatives thereof and intermediates thereto. In particular the present invention provides in one of the aspect a method for synthesis of compound of formula D a key intermediate of diphyllin, which can be carried out in a shorter duration and at an ordinary temperature. | 01-10-2013 |
| 20130072695 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 03-21-2013 |
| 20130184473 | Composition for Lowering Blood Lipid and Elevating High-density Lipoprotein and Method for Manufacturing the Same - The present invention discloses a composition for lowering blood lipid and elevating high-density lipoprotein and a method for manufacturing the same; the composition comprises monascin or ankaflavin, or a combination thereof; the manufacturing method comprises the steps of: treating a | 07-18-2013 |
| 20130338379 | PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN - Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: | 12-19-2013 |
| 20140330027 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES - The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is “one-pot” asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule. | 11-06-2014 |
| 20150299155 | Sesquiterpene lactone-based pharmaceutical composition for treating gastrointestinal diseases - The present invention relates to a sesquiterpene lactone-based pharmaceutical composition for treating gastrointestinal diseases. More particularly, the present invention relates to a pharmaceutical composition, containing as an active ingredient a sesquiterpene lactone-based derivative derived from parthenolide, for preventing or treating gastritis or gastric ulcers. | 10-22-2015 |
| 20150336919 | Sesquiterpene lactone-based pharmaceutical composition for treating gastrointestinal diseases - The present invention relates to a sesquiterpene lactone-based pharmaceutical composition for treating gastrointestinal diseases. More particularly, the present invention relates to a pharmaceutical composition, containing as an active ingredient a sesquiterpene lactone-based derivative derived from parthenolide, for preventing or treating gastritis or gastric ulcers. | 11-26-2015 |
| 20160030589 | Methods of Producing Cancer Compounds - Provided is a method for making the compound of Formula 1: | 02-04-2016 |
| 549300000 | Two of the cyclos share at least three ring members or ring carbon is shared by the three cyclos (e.g., bridged or peri compounds, etc.) | 2 |
| 20130096324 | PROCESS FOR PREPARING OPTICALLY ACTIVE ANTROCIN - The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone. | 04-18-2013 |
| 20130231491 | FLUORINATED MONOMER OF CYCLIC ACETAL STRUCTURE, POLYMER, RESIST PROTECTIVE COATING COMPOSITION, RESIST COMPOSITION, AND PATTERNING PROCESS - A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C | 09-05-2013 |
| 549302000 | Bicyclo ring system having the lactone ring as one of the cyclos | 19 |
| 20080207926 | PROCESS FOR PREPARATION OF 13,14-DIHYDRO-PGF2 ALPHA DERIVATIVES - The invention relates to a process for the preparation of 13,14-dihydro-PGF | 08-28-2008 |
| 20090275761 | Catalytic Preparation of Cyclic Carboxylic Esters - Preparation of cyclic esters by hydrogenation of a carbonyl group in at least one anhydride radical —C(O)—O—C(O)— of a cyclic dicarboxylic or polycarboxylic anhydride by means of hydrogen in the presence of a homogeneous noble metal catalyst, characterized in that the hydrogenation is carried out in a homogeneous reaction mixture using an iridium catalyst. The cyclic esters are obtained in good chemical and optical yields when prochiral anhydrides are used together with chiral iridium catalysts. | 11-05-2009 |
| 20100010239 | Process for the Production of Prostaglandins and Prostaglandin Analogs - The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF | 01-14-2010 |
| 20130245286 | PROCESS FOR PRODUCING WINE LACTONE - The present invention relates to a method comprising (A) reacting a β-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an α-methyl-γ-keto acid; and (C) reducing the resulting α-methyl-γ-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof. Alternatively, the present invention relates to a method comprising step (A) as recited above; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, followed by decarboxylation reaction to obtain an α-methyl-γ-keto acid ester; and (E) reducing the resulting α-methyl-γ-keto acid ester in the presence of a ruthenium complex having a specific structure and in the presence of a hydrogen donor to obtain wine lactone or a stereoisomer thereof or a mixture thereof. | 09-19-2013 |
| 549305000 | Chalcogen attached indirectly to the lactone ring by acyclic nonionic bonding | 5 |
| 20080249319 | Process for the preparation of 5-Carboxyphthalide - There is described a process for the preparation of 5-carboxy phthalide, which comprises adding terephthalic acid to fuming sulfuric acid containing at least 20% of SO | 10-09-2008 |
| 20090112002 | PROCESS FOR PREPARATION OF ALDONIC ACIDS AND DERIVATIVES THEREOF - A process for the preparation of L-gluconic acid or a salt thereof, comprises treating an aqueous solution of 6-bromo-6-deoxy-2,3-anhydro-D-manno-1,4-lactone with a base at a pH of at least 12 and at a temperature of 45 to 55° C. to obtain an aqueous solution of L-gluconic acid. | 04-30-2009 |
| 20100204489 | METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE - Disclosed is a method for preparing a prostaglandin derivative of formula (A): | 08-12-2010 |
| 20120283451 | PROCESS FOR THE PREPARATION OF F-SERIES PROSTAGLANDINS - A process for the synthesis and purification of F-series prostaglandin compounds and synthetic intermediates used to prepare them. The synthetic intermediates are solid and may be purified by precipitation and therefore may form the representative F-series prostaglandin compounds such as latanoprost, bimatoprost, fluprostenol, cloprostenol, and substituted analogs therefrom in highly pure forms. | 11-08-2012 |
| 20150299154 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES - The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is “one-pot” asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule. | 10-22-2015 |
| 549307000 | The other cyclo of the bicyclo ring system is benzene (e.g., phthalides, etc.) | 7 |
| 20120142946 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE - Disclosed is a method for producing a halogen-substituted phthalide, which includes a reaction step of reacting a halogen-substituted phthalic anhydride with sodium borohydride. | 06-07-2012 |
| 20130030193 | PROCESS FOR PRODUCING WINE LACTONE - The present invention relates to a method comprising (A) reacting a β-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an α-methyl-γ-keto acid; and (C) reducing the resulting α-methyl-γ-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof. Alternatively, the present invention relates to a method comprising step (A) as recited above; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, followed by decarboxylation reaction to obtain an α-methyl-γ-keto acid ester; and (E) reducing the resulting α-methyl-γ-keto acid ester in the presence of a ruthenium complex having a specific structure and in the presence of a hydrogen donor to obtain wine lactone or a stereoisomer thereof or a mixture thereof. | 01-31-2013 |
| 20130245287 | PROCESS FOR PRODUCING WINE LACTONE - The present invention relates to a method comprising (A) reacting a β-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an α-methyl-γ-keto acid; and (C) reducing the resulting α-methyl-γ-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof. Alternatively, the present invention relates to a method comprising step (A) as recited above; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, followed by decarboxylation reaction to obtain an α-methyl-γ-keto acid ester; and (E) reducing the resulting α-methyl-γ-keto acid ester in the presence of a ruthenium complex having a specific structure and in the presence of a hydrogen donor to obtain wine lactone or a stereoisomer thereof or a mixture thereof. | 09-19-2013 |
| 549308000 | Two carbocyclic rings bonded directly to the same ring atom of the lactone ring | 1 |
| 20100081831 | METHOD FOR PRODUCING PHENOLPHTHALEIN COMPOUND USING IONIC LIQUID CATALYST COMPOSITION - A method for producing a phenolphthalein compound is disclosed, comprising: reacting a phenolic compound of the formula: | 04-01-2010 |
| 549310000 | Additional chalcogen bonded directly to the bicyclo ring system | 3 |
| 20090240069 | Process for preparation of mycophenolic acid and ester derivatives thereof - Provided are processes for preparation of mycophenolic acid. | 09-24-2009 |
| 20110288313 | PROCESS FOR MODIFYING DRUG CRYSTAL FORMATION - A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the crystals, methods of treatment and uses thereof. | 11-24-2011 |
| 20150045564 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES - The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I | 02-12-2015 |
| 549311000 | The bicyclo ring system consists of two five-membered rings | 3 |
| 20120209011 | NOVEL PROCESS FOR THE PREPARATION OF PROSTAGLANDINS AND INTERMEDIATES THEREOF - This invention relates to novel process for the preparation of prostaglandin compounds having formula (K), | 08-16-2012 |
| 549312000 | Acyclic carbon chain containing carbon to carbon unsaturation attached directly or indirectly to the lactone ring by nonionic bonding | 2 |
| 20140343299 | PROCESS FOR THE PREPARATION OF TRAVOPROST - The invention relates to a process for the preparation of travoprost of formula (I), comprising that, the compound of formula (II), is stereo selectively reduced, the resulting compound of formula (III), is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV), is removed, the resulting triol of formula (V), is, if desired after crystallization, transformed by Wittig reaction into the acid of formula (VI), which is then esterified. | 11-20-2014 |
| 20160137621 | PROCESS FOR THE PREPARATION OF TRAVOPROST - The crystalline compound of formula (III) | 05-19-2016 |
