| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548556000 | Chalcogen attached indirectly to the five-membered hetero ring by acyclic nonionic bonding (e.g., 4-hydroxy -3-pyrrolidinemethanol, etc.) | 8 |
| 20080214837 | Synthetic Method of Optically Pure (S)-3-Hydroxypyrrolidine - A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction. | 09-04-2008 |
| 20080227988 | Crystallisation and Purification of Glycopyrronium Bromide - A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favours the R, S and S, R diastereoisomers over the R, R, and S, S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallisation steps. This method gives a product having a particle size of narrow distribution. | 09-18-2008 |
| 20110004006 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF - Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia. | 01-06-2011 |
| 20110230665 | SYNTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION - The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, | 09-22-2011 |
| 20130211101 | Crystalline Glycopyrrolate Tosylate - Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed. | 08-15-2013 |
| 20140243535 | CRYSTALLINE GLYCOPYRROLATE TOSYLATE - Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed. | 08-28-2014 |
| 20150031897 | COMBINED ACETYLCHOLINESTERASE INHIBITOR AND QUATERNARY AMMONIUM ANTIMUSCARINIC THERAPY TO ALTER PROGRESSION OF COGNITIVE DISEASES - A method administers quaternary ammonium anti-cholinergic muscarinic receptor antagonists in combination with acetyl-cholinesterase inhibitors to treat either cognitive impairment or acute delirium. This therapy results in a modification of a cognitive disorder or disease, namely a slow down in the disease progression. In one preferred embodiment, the disease is dementia with Lewy Bodies. New formulations for quaternary ammonium anti-cholinergic muscarinic receptor antagonists are also disclosed. | 01-29-2015 |
| 20160052879 | PROCESS FOR PRODUCTION OF GLYCOPYRRONIUM TOSYLATE - Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis. | 02-25-2016 |
