| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548543000 | Chalcogen bonded directly to a ring carbon of the five-membered hetero ring which is adjacent to the ring nitrogen (e.g., 2-pyrrolidones, etc.) | 69 |
| 20080214836 | Process for the synthesis of lauryllactam (L12) by gas phase catalytic rearrangement of cyclododecanone oxime - The present invention relates to a process for the preparation of lauryllactam in which a Beckmann rearrangement of cyclododecanone oxime is carried out. Said process is carried out in the gas phase at a temperature of between 180 and 450° C. in the presence of a microporous material having a three-dimensional inorganic main structure composed of tetrahedra connected via a common edge, called zeolite. | 09-04-2008 |
| 20100249434 | METHOD FOR THE VINYLATION OF AMIDES - A process for preparing an N-vinyl compound by vinylating a compound having at least one nitrogen atom (referred to hereinafter as compound for short) with acetylene, wherein
| 09-30-2010 |
| 20130296576 | HIGH STABLE NON-IONIC N-VINYL BUTYROLACTAM IODINE AND PREPARATION METHOD THEREOF - The present invention relates to a preparation method of a high-stable non-ionic N-vinyl butyrolactam iodine, wherein non-ionic N-vinyl butyrolactam, iodine and at least one grinding aid are stirred at 150-800 r/min at a temperature of 50° C.-90° C. for 1 to 12 hours to prepare the high-stable non-ionic N-vinyl butyrolactam iodine, wherein the K value of the non-ionic N-vinyl butyrolactam is 32±1, the PD value of the main peak of the non-ionic N-vinyl butyrolactam is ≦1.6, the moisture content of the non-ionic N-vinyl butyrolactam is ≦2.5%, preferably, the grinding aid is selected one or several from sodium chloride, sodium citrate, sodium carbonate and sodium phosphate, the amount of the grinding aid added is 0.02 to 2% of the total amount of the non-ionic N-vinyl butyrolactam and the iodine, the non-ionic N-vinyl butyrolactam is PVP-K32, the high-stable non-ionic N-vinyl butyrolactam iodine prepared by the above mentioned method is also provided, the stability of the high-stable non-ionic N-vinyl butyrolactam iodine of the present invention is high, thereby facilitating long-term storage and use, thus the high-stable non-ionic N-vinyl butyrolactam iodine is suitable for large-scale popularization. | 11-07-2013 |
| 20140012015 | PROCESS FOR PREPARING BICYCLIC AMINE DERIVATIVES - The present invention provides a process for preparing a bicyclic amine derivative of the formula (Ia) or (Ib), | 01-09-2014 |
| 20140058118 | ACIDS REMOVAL AND METHANE CONVERSION PROCESS USING A SUPERSONIC FLOW REACTOR - Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of acids from a hydrocarbon stream. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to another hydrocarbon process. The method according to certain aspects includes controlling the level of acids in the hydrocarbon stream by use of adsorbents or basic solutions. | 02-27-2014 |
| 20150025253 | PESTICIDAL ARYLPYRROLIDINES - Arylpyrrolidines of formula (I): | 01-22-2015 |
| 20160145197 | PROCESS FOR PREPARING BICYCLIC AMINE DERIVATIVES - The present invention provides a process for preparing a bicyclic amine derivative of the formula (Ia) or (Ib), | 05-26-2016 |
| 548544000 | And chalcogen bonded directly to a ring carbon of the five membered hetero ring which is not adjacent to the ring nitrogen (e.g., 2,4 pyrrolidinediones, etc.) | 11 |
| 20090253917 | 3-HYDRAZINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATES, PROCESS FOR PRODUCTION OF THE SAME, AND USE OF THE SAME - The present invention provides 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates of the formula (I): | 10-08-2009 |
| 20100152464 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS - Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed. | 06-17-2010 |
| 20100217014 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS - This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): | 08-26-2010 |
| 20110144355 | NOVEL COMPOUND SIGNAMYCIN, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF - A compound having a structure expressed by the following Structural Formula (1) and a compound having a structure expressed by the following Structural Formula (2): | 06-16-2011 |
| 20110207944 | VITAMIN D3 LACTAM DERIVATIVE - Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R | 08-25-2011 |
| 20130060049 | METHOD FOR PREPARING (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE - A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide is provided, which includes the steps of preparing the crude product and crystallizing, wherein acetone and water are used as solvents in the step of crystallizing. The (S)-oxiracetam prepared by the method of the present invention has high purity of more than 99.3% and low impurity of 0-0.5%, based on the percentages of the mass. According to the method of the present invention, with regard to the way of charging materials, adding inorganic base only just a few times is easier to handle and more convenient to the industrial manufacturing and application. | 03-07-2013 |
| 20140171659 | METHOD FOR PURIFYING (S)-OXIRACETAM - A method for purifying (S)-oxiracetam is disclosed. Crude (S)-oxiracetam with the purity of 89% is dissolved in water; the solution is allowed to stand for 1 to 3 days at 0° C. to 18° C.; a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water to 0° C. to 5° C.; and the product is dried in vacuum to obtain high-purity (S)-oxiracetam. | 06-19-2014 |
| 20140200355 | Method for Preparing Optically Pure (-)-Clausenamide Compound - Disclosed in the present invention is a method for preparing a (−)-clausenamide compound of formula (I), comprising: firstly, catalyzing the asymmetrical epoxidation of trans-cinnamate using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to transesterification, oxidation, cyclization and reduction successively to finally obtain the optically pure (−)-clausenamide compound of formula (I). | 07-17-2014 |
| 20140221670 | 4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE RACEMATE CRYSTAL FORM I AND PREPARATION METHOD THEREFOR - Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production. | 08-07-2014 |
| 20140235871 | (S)-4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE RACEMATE CRYSTAL FORM II AND PREPARATION METHOD THEREFOR - An (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide racemate referred to as (S)-oxiracetam crystal form II has a diffraction peak at a diffraction angle 2θ of 10.669, 13.25, 13.847, 14.198, 16.729, 17.934, 18.746, 18.816, 20.273, 20.413, 21.431, 21.617, 21.663, 23.38, 24.324, 24.415, 26.069, 26.107, 27.901, 28.621, 28.925, 29.449, 29.484, 31.702, 36.516, 37.685, or 39.721 degrees. The purity of the (S)-oxiracetam crystal form II can be up to 98.5%, and the (S)-oxiracetam crystal form II has the advantages of simple preparation method, mild control condition, low production cost, and the produced oxiracetam hydrate crystal form II has a high purity (the oxiracetam hydrate crystal form having a purity of 8%˜98.5% can be prepared by a crude levo-oxiracetam having a purity of 92%, and thus having a good reproducibility in production. | 08-21-2014 |
| 20140303383 | METHOD FOR PURIFYING LEVO-OXIRACETAM - A method for purifying levo-oxiracetam is disclosed. Crude levo-oxiracetam is dissolved in water; an organic solvent is added dropwise into the solution until the solution just turns turbid; the solution is allowed to stand for 1 to 3 days at 0° C. to 18° C.; a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water of 0° C. to 5° C.; and the product is dried in vacuum to obtain high-purity levo-oxiracetam. | 10-09-2014 |
| 548545000 | And chalcogen bonded directly to the other ring carbon of the five-membered hetero ring which is adjacent to the ring nitrogen (e.g., succinimide, etc.) | 17 |
| 20100145072 | Process for Producing Cyclic Compounds - The invention includes methods of processing an initial di-carbonyl compound by conversion to a cyclic compound. The cyclic compound is reacted with an alkylating agent to form a derivative having an alkylated ring nitrogen. The invention encompasses a method of producing an N-alkyl product. Ammonia content of a solution is adjusted to produce a ratio of ammonia to di-carboxylate compound of from about 1:1 to about 1.5:1. An alkylating agent is added and the initial compound is alkylated and cyclized. The invention includes methods of making N-methylpyrrolidinone (NMP). Aqueous ammonia and succinate is introduced into a vessel and ammonia is adjusted to provide a ratio of ammonia to succinate of less than 2:1. A methylating agent is reacted with succinate at a temperature of from greater than 100° C. to about 400° C. to produce N-methyl succinimide which is purified and hydrogenated to form NMP. | 06-10-2010 |
| 20110263874 | Process for Producing Cyclic Compounds - The invention includes methods of processing an initial di-carbonyl compound by conversion to a cyclic compound. The cyclic compound is reacted with an alkylating agent to form a derivative having an alkylated ring nitrogen. The invention encompasses a method of producing an N-alkyl product. Ammonia content of a solution is adjusted to produce a ratio of ammonia to di-carboxylate compound of from about 1:1 to about 1.5:1. An alkylating agent is added and the initial compound is alkylated and cyclized. The invention includes methods of making N-methyl pyrrolidinone (NMP). Aqueous ammonia and succinate is introduced into a vessel and ammonia is adjusted to provide a ratio of ammonia to succinate of less than 2:1. A methylating agent is reacted with succinate at a temperature of from greater than 100° C. to about 400° C. to produce N-methyl succinimide which is purified and hydrogenated to form NMP. | 10-27-2011 |
| 20120190867 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE - A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) | 07-26-2012 |
| 20120323018 | Preparation of Monomers for Grafting to Polyolefins, and Lubricating Oil Compositions Containing Grafted Copolymer - A graft copolymer containing one or more ethylenically-unsaturated, aliphatic or aromatic, nitrogen- and oxygen-containing graftable monomers grafted to a polyolefin is disclosed. Novel monomers, methods of making such monomers, and graft copolymers comprising such monomers are based on reacting an acylating agent with an amine to form a reaction product. The reaction product may include more than one chemical compound formed from the combination of the acylating agent and the amine. The monomer is the graftable, ethylenically unsaturated, aliphatic or aromatic, nitrogen- and oxygen-containing compound(s) of the reaction product. The monomer may, but need not, be recovered from the product mixture. The preferred monomer is the reaction product of malcic anhydride and 4-aminodiphenylamine. Also described is a method of making a dispersant viscosity index improver. The monomer of the present invention may be grafted to a polyolefin in solutions or melts. Also described is a lubricating oil comprising a base oil and a grafted polyolefin as described above. | 12-20-2012 |
| 548546000 | Nitrogen attached directly or indirectly to the five-membered hetero ring by acyclic nonionic bonding | 4 |
| 20100004464 | Method for producing succinimide compound - There is provided a method for producing a succinimide compound. The method for producing a succinimide compound of formula (3) comprises reacting an aminomalonic ester compound of formula (1) with a compound of formula (2) in a solvent in the presence of a base, wherein an alcohol is used as the solvent and an alkali metal alkoxide is used as the base. | 01-07-2010 |
| 20110245509 | POLYFUNCTIONAL POLYOXYALKYLENE COMPOUND, AND PRODUCING METHOD AND INTERMEDIATE THEREOF - A polyfunctional polyoxyalkylene compound represented by the following formula (1): | 10-06-2011 |
| 20120253053 | POLYOXYALKYLENE-MODIFIED LIPID AND METHOD FOR PRODUCING THE SAME - Provided are a thiol-reactive polyoxyalkylene-modified lipid which can be used to chemically modify bioactive substances and which can be used for drug delivery systems such as liposomes and a method for producing the same. The polyoxyalkylene-modified lipid is represented by the following formula (1): | 10-04-2012 |
| 20160046763 | HYDROPHILIC POLYMER DERIVATIVE HAVING BENZYLIDENE ACETAL LINKER - A hydrophilic polymer derivative having a benzylidene acetal linker whose hydrolysis rate at the pH of a weakly acidic environment in the living body can be accurately controlled. A hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by the following formula (1): | 02-18-2016 |
| 548547000 | Chalcogen attached indirectly to the five-membered hetero ring by acyclic nonionic bonding | 6 |
| 20080255370 | SINGLE CARBON PRECURSOR SYNTHONS - The chemistry of [ | 10-16-2008 |
| 20090192320 | MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE - A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: | 07-30-2009 |
| 20100311986 | PREPARING METHOD OF METHOXYPOLYETHYLENEGLYCOL ETHYLMALEIMIDE - The present invention relates to a process for preparing methoxy polyethylene glycol ethylmaleimide (abbreviated to as “mPEG-ethylmaleimide”) and derivatives thereof with high purity.
| 12-09-2010 |
| 20110269974 | Polymer Derivatives - The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative. | 11-03-2011 |
| 20140073802 | MALEIMIDYL POLYMER DERIVATIVES - The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents. | 03-13-2014 |
| 20160083514 | N-MALEIMIDYL POLYMER DERIVATIVES - The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives. | 03-24-2016 |
| 548548000 | Carbon to carbon unsaturation between ring members of the five-membered hetero ring (e.g., maleimide, etc.) | 3 |
| 20120289711 | METHOD FOR PRODUCING CARBON NANOMATERIALS AND/OR CARBON MICROMATERIALS AND CORRESPONDING MATERIAL - The present invention relates to a method for producing carbon nanomaterials and/or carbon micromaterials, in particular multi-wall carbon nanotubes. This method is characterized according to the invention in that the materials, in particular the side walls of the materials, undergo microwave-assisted functionalization. In addition, a correspondingly modified material is described. | 11-15-2012 |
| 20140031563 | New compounds for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof - New compounds and pharmaceutical compositions comprising active ingredients having inhibition effects on osteoclast differentiation are provided. The pharmaceutical compositions comprising the new compounds can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease. | 01-30-2014 |
| 548549000 | Benzene ring bonded directly to ring nitrogen of the five-membered hetero ring (e.g., N-phenylmaleimide, etc.) | 1 |
| 20110124882 | Method for Preparing N-Substituted Maleimides - The present invention relates to a method of preparing N-substituted maleimide in high purity and high yield, wherein, unlike a conventional method of preparing N-substituted maleimide after preparing N-substituted maleamic acid, an organic solvent, an acid catalyst, a dehydration co-catalyst and a stabilizer are added into a reactor without separately preparing N-substituted maleamic acid, and then a primary amine is added into the reactor to form an amine salt, maleic anhydride is added into the reactor, and the resulting mixture is subjected to a dehydration-cyclization reaction, wherein water produced during the reaction is azeotropically distilled with the organic solvent so as to effectively suppress formation of a maleimide polymer. Particularly, the invention simplifies the process, has high yield, minimizes side reactions, eliminates the introduction of expensive raw materials and the complicated treatment of the reaction solution and significantly shortens the time over which the raw materials and maleic anhydride are added. | 05-26-2011 |
| 548550000 | Nitrogen attached directly or indirectly to the five-membered hetero ring by acyclic nonionic bonding | 13 |
| 20090012313 | 3-Carboxy-2-Oxo-1-Pyrrolidine Derivatives and Their Uses - The present invention relates to 3-carboxy-2-oxo-1-pyrrolidine derivatives of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof, and processes using them. | 01-08-2009 |
| 20090247770 | PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS - The present invention is directed to a process for preparing α,α disubstituted γ-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety. | 10-01-2009 |
| 20090318708 | 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses - The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives. | 12-24-2009 |
| 20100022784 | N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use - The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia. | 01-28-2010 |
| 20100076204 | PROCESS FOR THE PREPARATION OF LEVETIRACETAM - The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide derivative. | 03-25-2010 |
| 20100145073 | N-SUBSTITUTED PYRROLIDONIUM IONIC LIQUIDS - This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker, which compounds may be represented by the structure of the following Formula I: | 06-10-2010 |
| 20100145074 | FUNCTIONALIZED N-SUBSTITUTED PYRROLIDONIUM IONIC LIQUIDS - This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker. | 06-10-2010 |
| 20110021786 | Pharmaceutical Solutions, Process of Preparation and Therapeutic Uses - The present invention concerns a stable pharmaceutical solution, a process of the preparation thereof and therapeutic uses thereof. | 01-27-2011 |
| 20110065932 | Process for the preparation of Levetiracetam - A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (−)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia. | 03-17-2011 |
| 20110137048 | FUNCTIONALIZED N-SUBSTITUTED PYRROLIDONIUM IONIC LIQUIDS - This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker. | 06-09-2011 |
| 20120130088 | N-Substituted Pyrrolidonium Ionic Liquids with Expanded Linker - This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker. | 05-24-2012 |
| 20120215010 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY - The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia. | 08-23-2012 |
| 20140288315 | OLIGOMER-CONTAINING PYRROLIDINE COMPOUNDS - The invention relates to (among other things) oligomer-containing pyrrolidine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer. | 09-25-2014 |
| 548551000 | Chalcogen attached indirectly to the five-membered hetero ring by acyclic nonionic bonding | 6 |
| 20090069575 | Process For The Preparation Of (S)-Alpha-Ethyl-2-Oxo-1-Pyrrolidineacetamide And (R)-Alpha-Ethyl-2-Oxo-Pyrrolidineacetamide - A process provided for the preparation of the (S)— and (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide of formula:(1) from (RS)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid of formula:(2) comprising: i) combining the (RS)-2 with a chiral base (resolving agent) in a resolution solvent and crystallizing from the said mixture the diastereomeric salt of (S)— or (R)-2 and chiral base; ii) regenerating (S)— or (R)-2 from the crystallized diastereomeric salt by treating with a suitable acid or acidic ion-exchange resin; iii) optionally regenerating (R)— or (S)-2 or their mixture (predominantly one enantiomer) from the crystallization mother liquor by treating with a suitable acid or acidic ion-exchange resin; iv) optionally epimerizing (RS)-2 by treating (R)— or (S)-2 or their mixture (predominantly one enantiomer) of step iii with an acid anhydride; V) optionally converting (RS)-2 of step iv into enantiomerically enriched (S)— or (R)-2 through steps i and ii; vi) formation of the mixed anhydride by reacting (R)— or (S)-2 with an alkyl or aryl sulfonyl halogen compound RSO2X in the presence of a suitable base; and vii) reacting the mixed anhydride with ammonia; wherein R represents C 1 to C 15 alkyl or aryl groups such as methyl, ethyl, p-toluenyl, 2,4,6-trimethylbenzyl, 2,4,6-trichloribenzyl, and X represents a halogen atom such as F, Cl and Br atoms. | 03-12-2009 |
| 20100010236 | CATALYTIC PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N-HYDROXYALKYLATED LACTAMS - A process for preparing (meth)acrylic esters (F) of N-hydroxyalkylated lactams, in which cyclic N-hydroxyalkylated lactams (L) | 01-14-2010 |
| 20120041212 | PROCESS FOR THE PREPARATION OF PREGABALIN - The present invention provides a new enantioselective method of preparing (S)-3-(aminomethyl)-5-methylhexanoic acid, commonly known as pregabalin. The invention also provides new chiral intermediates useful in the production of pregabalin. | 02-16-2012 |
| 20120123134 | Manufacturing process for (S)-Pregabalin - The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds of general formula I used for treatment of epilepsy, neuropathic pain, anxiety and social phobia. The invention describes preparation of enantiomerically pure (S)-Pregabalin from chiral pyrrolidin-2-one of formula IV. | 05-17-2012 |
| 20130178637 | PROCESSES FOR THE PRODUCTION OF PYRROLIDONES - Processes for making pyrrolidones include providing a clarified diammonium succinate (DAS)-containing and/or monoammonium succinate (MAS)-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of greater than 100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling and/or evaporating the bottoms to attain a temperature and composition sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid SA portion to pyrrolidones. | 07-11-2013 |
| 20140171660 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OX- O-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID - Methods of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid are disclosed. Also provided are pharmaceutical compositions comprising (+)-1,4-dihydro-7-[(3S,45)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, and methods of treatment using such compositions. | 06-19-2014 |
| 548552000 | Processes of forming 2-pyrrolidone which is unsubstituted or alkyl or alkenyl substituted only | 5 |
| 20110034706 | PROCESS FOR PREPARING N-VINYLPYRROLIDONE FROM LACTONE-FREE PYRROLIDONE - A process for preparing N-vinylpyrrolidone by reacting 2-pyrrolidone with acetylene, wherein the 2-pyrrolidone used as a starting material (referred to hereinafter as starting 2-pyrrolidone) comprises less than 1 part by weight of γ-butyrolactone per 100 parts by weight of 2-pyrrolidone. | 02-10-2011 |
| 20150065731 | PROCESS FOR MICROWAVE ASSISTED SYNTHESIS OF N-METHYL PYRROLIDONE - The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogues by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min. | 03-05-2015 |
| 548554000 | Directly from a -COO- containing compound (e.g., from methyl acrylate, etc.) | 3 |
| 20090187030 | PROCESS FOR CONTINUOUSLY PREPARING N-ETHYL-2-PYRROLIDONE (NEP) - Process for the continuous preparation of N-ethyl-2-pyrrolidone (NEP) by reacting gamma-butyrolactone (GBL) with monoethylamine (MEA) in the liquid phase, wherein GBL and MEA are used in a molar ratio in the range from 1:1.08 to 1:2 an the reaction is carried out at a temperature in the range from 320 to 420° C. and an absolute pressure in the range from 70 to 120 bar. | 07-23-2009 |
| 20130144070 | PROCESSES FOR THE PRODUCTION OF PYRROLIDONES - Processes for making pyrrolidones include making MAS and/or SA from a clarified DAS- and/or MAS-containing fermentation broth and converting the MAS or SA to the pyrrolidones, typically with catalysts at selected temperatures and pressures. | 06-06-2013 |
| 20150322026 | HYDROGENATION PRODUCTS FROM BIOLOGICALLY-DERIVED CARBOXYLIC-ACID ESTERS - The production of organic acids in low-cost, high-efficiency fermentation system makes available a new route to chemical production from biomass. A process for producing a hydrogenation product involving carboxylic acid esters recovered directly from a fermentation process is described. | 11-12-2015 |
| 548555000 | Purification or recovery of 2-pyrrolidone which is unsubstituted or alkyl substituted only | 10 |
| 20090018347 | PROCESS FOR PURIFYING REMOVAL OF ACRYLIC ACID, METHACRYLIC ACID, N-VINYLPYRROLIDONE OR P-XYLENE CRYSTALS FROM THEIR SUSPENSION IN MOTHER LIQUOR - A process for purifying removal of acrylic acid, methacrylic acid, N-vinylpyrrolidone or p-xylene crystals from their suspension in mother liquor by means of a wash column with forced transport, whose shell of the process chamber is a metal wall, the wash column additionally being enveloped by a thermal insulation material having a water vapor barrier and a specific heat flow of >0.1 W/m | 01-15-2009 |
| 20090076285 | PROCESS FOR THE TREATMENT OF AN AQUEOUS MIXTURE COMPRISING A DIPOLAR APROTIC COMPOUND - The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound. | 03-19-2009 |
| 20090076286 | PROCESS FOR OPERATING A CONTINUOUS REMOVAL OF A TARGET PRODUCT X IN THE FORM OF FINE CRYSTALS - A process for continuously removing a target product X in the form of fine crystals from a liquid phase P comprising the target product X and constituents other than the target product X by cooling suspension crystallization in an indirect heat transferee, in which the crystal suspension formed is conducted out of the heat transferer first into a mixed buffer tank and, from there, fed to an apparatus for separating the crystal suspension into crystals and liquid phase, and wherein external measures dissipade the oversaturation of the crystal suspension fed to the buffer vessel with target product X. | 03-19-2009 |
| 20090088579 | Production Method of N-Vinyl-2-Pyrrolidone - High-purity NVP can be produced by comprising at least two crystallization processes and supplying the mother liquor from the first crystallization process to the second crystallization process. | 04-02-2009 |
| 20110218344 | PRODUCTION METHOD OF N-VINYL-2-PYRROLIDONE - A method for producing N-vinyl-2-pyrrolidone by crystallization including: controlling a water content in a feed N-vinyl-2-pyrrolidone solution at an inlet of a crystallizer so as to be not lower than 0.7% by weight and not higher than 10% by weight based on the total weight of the N-vinyl-2-pyrrolidone solution; and supplying the feed N-vinyl-2-pyrrolidone solution to a crystallization process. | 09-08-2011 |
| 20110245510 | PROCESS FOR REMOVING BY-PRODUCTS FROM N-VINYLAMIDES - A process for removing by-products from N-vinylamide-rich product mixtures (crude N-vinylamide), which comprises performing an extraction of the crude N-vinylamide with an organic solvent as the extractant. | 10-06-2011 |
| 20120071670 | METHOD FOR PRODUCING OF ULTRA-CLEAN AND HIGH-PURITY N-METHYL PYRROLIDONE - The present invention provides a method for producing of ultra-clean and high-purity N-methyl pyrrolidone through using industrial grade N-methyl pyrrolidone as raw material. After the pretreatment, sorption and dehydration with 4A molecular sieve, twice membrane filtrations are carried out through using β-cyclodextrin composite membrane for the first and 18-crown-6 composite membrane for the second. The filtrate is rectified under vacuum and filtered through using complexant composite microporous membrane to obtain the product. The ultra-clean and high-purity N-methyl pyrrolidone, produced by the method provided by the present invention, is up to the SEMI C8 standard. And the purity of the product is over 99.8%, the moisture content is less than 0.03%, and the content of single metal ion is less than 1 ppb. Comparing to the prior art, the present invention has the advantage such as the stable quality of the product, simple operation, and is suitable for industrial continuous production. | 03-22-2012 |
| 20130150591 | METHOD FOR PURIFYING N-ALKYL-SUBSTITUTED PYRROLIDONES BY HYDROGENATION - The invention relates to a method for purifying N-alkyl-substituted pyrrolidones which have contaminants with a higher degree of oxidation, by hydrogenation of the same and distillation. | 06-13-2013 |
| 20140142323 | PROCESS FOR PURIFYING N-ALKYLPYRROLIDONES - Process for purifying N-alkylpyrrolidones which due to a previous use comprise at least one of the impurities of the formula I or II | 05-22-2014 |
| 20140187796 | PROCESS FOR THE TREATMENT OF A RECYCLYING STREAM FROM A PLANT FOR THE PRODUCTION OF POLYARYLENE ETHER SULFONES - A process is proposed for the treatment of a recycling stream ( | 07-03-2014 |
