| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548517000 | Additional hetero ring, which is attached directly or indirectly to the five-membered hetero ring by nonionic bonding | 64 |
| 20080262246 | 3-Alkyl-5- (4-Alkyl-5-Oxo-Tetrahydrofutr An -2-Yl) Pyrrolidin-2-One Derivatives As Intermediates In The Synthesis Of Renin Inhibitors - The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, | 10-23-2008 |
| 20090062553 | Process and Intermediates Useful in the Preparation of Statins, Particularly Atorvastatin - There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein R | 03-05-2009 |
| 20090221839 | Preparation of an Atorvastatin Intermediate - Atorvastatin lactone is prepared by hydrogenating tert-butyl isopropylidene nitrile to tert-butyl isopropylidene amine and condensing the amine with the diketone of atorvastatin to form acetonide ester. The diol protecting acetonide ester is deprotected to form a diol ester by dissolving the acetonide ester in methanol and treating with an acid. The diol ester is saponified to form a sodium salt. Methanol is removed from the reaction mixture by distillation. The sodium salt is reacidified to the free diol acid and atorvastatin lactone is formed from the diol acid. The atorvastatin lactone is directly dried without further purification. | 09-03-2009 |
| 20100197939 | PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN - The invention provides a new enantioselective process for the preparation of (S)-pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) to obtain compound of general formula (II); oxidation of compound (II) to obtain a compound of general formula (III) and transforming compound (III) into compound of general formula (IV); subjecting compound (IV) to basic hydrolysis to obtain a compound of general formula (V) which is reduced to obtain enantiomerically pure S-pregabalin. The invention also provides new chiral intermediates involved in the process. | 08-05-2010 |
| 20100267965 | 3-Alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one Derivatives as Intermediates in the Synthesis of Renin Inhibitors - The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, | 10-21-2010 |
| 20100274027 | ORGANIC COMPOUNDS - The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Allskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, | 10-28-2010 |
| 20110105767 | Manufacturing process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren - The invention describes a novel technical process and novel intermediates useful for the manufacture of enantiomerically pure 8-aryloctanoic acids of the formula I which are pharmaceutically active compounds as rennin inhibitors. | 05-05-2011 |
| 20110112309 | PREPARATION PROCESS USEFUL IN SYNTHESIS OF ATORVASTATIN - The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t-butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis. | 05-12-2011 |
| 20110137047 | Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren - The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III. | 06-09-2011 |
| 20120309985 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS - In one aspect, the invention relates to compounds of formula I: | 12-06-2012 |
| 20130066083 | PROCESSES AND INTERMEDIATES - The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. | 03-14-2013 |
| 20130178636 | ESTERS OF HEXANOIC ACIDS AS INTERMEDIATES FOR THE PREPARATION OF ATORVASTATIN - The invention relates to compounds of general formula (3) wherein R | 07-11-2013 |
| 20150126750 | PROCESS FOR PREPARING 4-AMINO-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-PENTANOIC ACID COMPOUND - The invention provides processes for preparing intermediates useful for preparing compounds of the formula: | 05-07-2015 |
| 548518000 | The additional hetero ring also contains nitrogen | 35 |
| 20090270638 | METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF PORPHYRINS - A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: | 10-29-2009 |
| 20100069648 | Adamantane-Dipyrromethane Derivatives, Method Of Preparation And Applications In Anion Sensing - Aamantane dipyrromethane derivatives are obtained by reacting adamantane carbonyl derivatives with pyrrole or pyrrole derivative, in the presence of acid. Adamantane-dipyrromethanes are used to bind anions of the group consisting of: F—, Cl—, Br—, acetate, HSO4— NO3—, and H2PO4—, and particularly F—. | 03-18-2010 |
| 20100286410 | Polymorphic Forms Of A 3-Pyrrole Substituted 2-Indolinone - The invention relates to new crystalline polymorphic forms of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (i.e., sunitinib base), including Form I, Form II, and Form IV, processes for preparing crystalline polymorphic forms of sunitinib base, and pharmaceutically acceptable salts of new crystalline polymorphic forms of sunitinib base and pharmaceutical compositions comprising new crystalline polymorphic forms of sunitinib base, salts of new crystalline polymorphic forms of sunitinib base and mixtures thereof. | 11-11-2010 |
| 20110046397 | NEW PROCESSES - The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, | 02-24-2011 |
| 20110295020 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane - The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence. | 12-01-2011 |
| 20120209009 | SYNTHETIC ROUTE TO ABCD-PORPHYRINS - A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described. | 08-16-2012 |
| 20120253052 | METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF PORPHYRINS - A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: | 10-04-2012 |
| 20140187795 | CRTH2 MODULATORS AND PREPARATION THEREOF - The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I). | 07-03-2014 |
| 20150322108 | CRYSTALLINE POLYMORPHS - The present invention features crystalline forms of Compound I. | 11-12-2015 |
| 548519000 | Ring carbon of each of the two nitrogen containing hetero rings is bonded directly to chalcogen (e.g., both rings may be bonded to the same oxygen atom or to different oxygen atoms, etc.) | 17 |
| 20130079528 | GEOMETRIC SYNTHESIS OF PORPHYRIN RODS - A method of making a compound of Formula I′ | 03-28-2013 |
| 20130096318 | MESO-BILIVERDIN COMPOSITIONS AND METHODS - Methods and materials for producing meso-biliverdin are provided where the methods include reacting phycocyanobilin with an amphoteric compound in a solvent to yield meso-biliverdin. | 04-18-2013 |
| 20130289284 | RENEWABLE MODIFIED NATURAL COMPOUNDS - Provided are modified natural compounds that are produced, at least in part, from (A) at least one epoxidized and/or maleated natural fatty acid, or epoxidized and/or maleated natural oil, and (B) at least one lactam having at least one hydroxyl functional group, wherein the lactam may be in a blend with one or more optional alcohol(s). Among other properties, the modified natural compounds may exhibit dispersibility or solubility characteristics in water and/or alcohols. The invention further provides a wide variety of compositions comprising the modified natural compounds. | 10-31-2013 |
| 548520000 | Plural chalcogens bonded directly to ring carbons of each of the two nitrogen containing hetero rings (e.g., bis-succinimides, etc.) | 14 |
| 20100197940 | Method for Preparing FMOC-Based Hydrolysable Linkers - A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)-based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs. | 08-05-2010 |
| 20110118479 | Branched Succinimide Dispersant Compounds and Methods of Making the Compounds - In accordance with the disclosure, one aspect of the present application is directed to a dispersant compound comprising the reaction product of (i) a hydrocarbyl carbonyl compound, (ii) a polycarbonyl compound having at least three carbonyl acylating functions, and (iii) a primary amine moiety of a polyamine. Methods of making and methods of using the dispersant compound are also disclosed. | 05-19-2011 |
| 20140288314 | PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS - A process provides for producing chiral prostacyclin derivatives of Formula (I) | 09-25-2014 |
| 20150291522 | DENDRITIC CORE COMPOUNDS - The invention relates to compounds that are useful for the preparation of dendrimer compounds, the use of these compounds for preparing dendrimers and processes for preparing the compounds. | 10-15-2015 |
| 20160039753 | FUNCTIONALIZED POLYMERS CONTAINING POLYAMINE SUCCINIMIDE FOR ANTIFOULING IN HYDROCARBON REFINING PROCESSES - A multipurpose chemical additives (MPC) is disclosed to mitigate fouling in hydrocarbon refinery processes, such as in a heat exchanger. A method for reducing fouling of a hydrocarbon is also disclosed that includes (i) providing a crude hydrocarbon for a refining process; and (ii) adding an additive to the crude hydrocarbon. | 02-11-2016 |
| 20160075648 | FUNCTIONALIZED POLYMERS CONTAINING POLYAMINE SUCCINIMIDE FOR ANTIFOULING IN HYDROCARBON REFINING PROCESSES - A multipurpose chemical additives (MPC) is disclosed to mitigate fouling in hydrocarbon refinery processes, such as in a heat exchanger. A method for reducing fouling of a hydrocarbon is also disclosed that includes (i) providing a crude hydrocarbon for a refining process; and (ii) adding an additive to the crude hydrocarbon. | 03-17-2016 |
| 20160075649 | FUNCTIONALIZED POLYMERS CONTAINING POLYAMINE SUCCINIMIDE FOR ANTIFOULING IN HYDROCARBON REFINING PROCESSES - A multipurpose chemical additives (MPC) is disclosed to mitigate fouling in hydrocarbon refinery processes, such as in a heat exchanger. A method for reducing fouling of a hydrocarbon is also disclosed that includes (i) providing a crude hydrocarbon for a refining process; and (ii) adding an additive to the crude hydrocarbon. | 03-17-2016 |
| 20160089446 | Modified Hydrogels - The present invention relates to a process for the preparation of a hydrogel suitable as carrier in a hydrogel-linked prodrug, to hydrogels obtainable from said process, the use of such hydrogel as a carrier in a hydrogel-linked prodrug and to hydrogel-linked prodrugs comprising a covalently conjugated hydrogel of the present invention. The hydrogel prodrug carrier has a reduced drug loading on the outside of the hydrogel carrier. This is achieved by reducing the number of functional groups of the hydrogel, in particular those at its surface. | 03-31-2016 |
| 20160200867 | ALKOXYLATION METHODS | 07-14-2016 |
| 548521000 | Double bond between ring carbons in each of the two nitrogen containing hetero rings (e.g., bis-maleimides, etc.) | 5 |
| 20100036136 | Maleimide Containing Ester and Sulfide Functionalities - An oligomeric compound that is the Michael addition reaction product of a thiol with a compound having maleimide terminal groups and ester functionality internal in the compound can be formulated into curable compositions to improve adhesion to metal substrates. | 02-11-2010 |
| 20100094024 | ACTIVE ENERGY RAY CURABLE LIQUID COMPOSITION AND LIQUID CARTRIDGE - The invention provides an active energy ray curable liquid composition containing a compound represented by a general formula (I): | 04-15-2010 |
| 20100168442 | PENTAARYLDIAMINE-CONTAINING BISMALEIMIDE COMPOUND AND PRODUCING METHOD THEREOF - A pentaaryldiamine-containing bismaleimide compound of Formula (I): | 07-01-2010 |
| 20130253207 | N-MALEIMIDYL POLYMER DERIVATIVES - The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives. | 09-26-2013 |
| 20140256957 | N-Maleimidyl Polymer Derivatives - The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives. | 09-11-2014 |
| 548523000 | Ring nitrogens of the two nitrogen containing hetero rings are bonded directly to the same atom or chain, which chain may include a ring | 9 |
| 20100145070 | ANTI-CANCER COMPOUND AND MANUFACTURING METHOD THEREOF - Anti-cancer compounds and manufacturing methods thereof are disclosed. The anti-cancer compounds are 1,8-diamidoanthraquinone derivatives with amino compounds. The manufacturing method includes the steps of: add 1,8-bis(chloroacetamido)anthraquinone or 1,8-bis(3-chloropropionamido)-anthraquinone with amino compounds, catalysts, and dehydrated dimethylformamide (DMF) to form a mixture and react with one another. Then by purification and recrystallization, the anti-cancer compounds are obtained. The anti-cancer compounds of the present invention are compounds with whole new structure that overcome serious cardiac toxicity of the conventional anti-cancer drug-doxorubincin. | 06-10-2010 |
| 20130172576 | BRANCHED HETERO POLYFUNCTIONAL POLYOXYALKYLENE COMPOUND AND INTERMEDIATE THEREOF - A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1): | 07-04-2013 |
| 548524000 | The atom is carbon or the chain consists of carbons | 7 |
| 20090247769 | COLORANT - A colorant contains a crystal of a compound represented by the following formula (1): | 10-01-2009 |
| 20120289710 | INTERMEDIATES OF NEUTRAL ENDOPEPTIDASE INHIBITORS AND PREPARATION METHOD THEREOF - The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof. | 11-15-2012 |
| 20140336394 | EMM-23 Molecular Sieve Materials, Its Synthesis and Use - A new molecular sieve material is designated as EMM-23 and has, in its as-calcined form, an X-ray diffraction pattern including the following peaks in Table 1: | 11-13-2014 |
| 20150073155 | MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF, AND METHOD FOR PRODUCING SAME - Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1): | 03-12-2015 |
| 20150328627 | Synthesis of ZSM-5 - A molecular sieve having the framework structure of ZSM-5 is produced using one or more of 1,4-bis(N-pentylpyrrolidinium)butane dications, 1,5-bis(N-pentylpyrrolidinium)pentane dications, and 1,6-bis(N-pentylpyrrolidinium)hexane dications as a structure directing agent. | 11-19-2015 |
| 20160039779 | EMM-23 Molecular Sieve Material, Its Synthesis and Use - A new molecular sieve material is designated as EMM-23 and has, in its as-calcined form, an X-ray diffraction pattern including the following peaks in Table 1: | 02-11-2016 |
| 20160060217 | Processes - The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, | 03-03-2016 |
| 548525000 | Polycyclo ring system which includes ring chalcogen | 12 |
| 20080214835 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 09-04-2008 |
| 20080221338 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 09-11-2008 |
| 20080269503 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 10-30-2008 |
| 20080269504 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 10-30-2008 |
| 20080269505 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 10-30-2008 |
| 20080312455 | Method For Determining Enantiomeric Purity Of Darifenacin And Intermediates - The present invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity, of darifenacin and its intermediate compounds and salts thereof. In addition, the invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity of compounds of formula (I): | 12-18-2008 |
| 20090018346 | Amorphous Form Of Darifenacin Hydrobromide And Processes For The Preparation Thereof - The present invention relates to amorphous form darifenacin hydrobromide and processes therefor. In addition, the present invention relates to compositions comprising amorphous form darifenacin hydrobromide. | 01-15-2009 |
| 20090156831 | PROCESSES FOR PREPARING DARIFENACIN HYDROBROMIDE - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 06-18-2009 |
| 20090306406 | METHOD FOR PREPARING 1,3-DISUBSTITUTED PYRROLIDINE COMPOUNDS - A process for preparing substituted pyrrolidine compounds, including (5)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide, commonly known in the art as darifenacin, comprising reacting a pyrrolidine compound with a benzofuran derivative in the presence of a phase-transfer catalyst. | 12-10-2009 |
| 20100317871 | METHOD FOR THE PREPARATION OF DARIFENACIN HYDROGEN BROMIDE - A method of preparing (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl}-α,α-diphenyl-3-pyrrolidine acetamide hydrogen bromide, wherein 3-(S)-(I-carbamoyl-1,1-diphenylmethyl)pyrrolidine or its salt with an organic acid is alkylated in the presence of an inorganic base with 5-(2-bromoethyl)-2,3-dihydrobenzofurane in a heterogeneous system of the solvents water and an organic solvent selected from C6 to C9 aliphatic, alicyclic or aromatic hydrocarbons, after separation of the two phases the crude darifenacin base is isolated, which is converted to the hydrobromide by addition of a C3 to C9 ketone or C3 to C9 alcohol and concentrated hydrobromic acid. | 12-16-2010 |
| 20110040103 | PREPARATION OF PENTAFLUOROSULFANYL (SF5) HETEROCYCLES: PYRROLES AND THIOPHENES - The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis. | 02-17-2011 |
| 20120077989 | CYCLIC IMIDATE LIGANDS - The present invention relates to a use of a cyclic imidate as a ligand for catalysis in which the ligand contains sub-structure (Y) as a minimal structural motive, wherein the carbon atoms and the nitrogen atom can be optionally substituted by a chemical substituent. | 03-29-2012 |
| 548527000 | Sulfur containing hetero ring | 4 |
| 20090286992 | FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES - An iodonium compound of formula (I): | 11-19-2009 |
| 20100317872 | THERAPEUTIC COMPOUNDS - A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC | 12-16-2010 |
| 20140058117 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED GAMMA LACTAMS - The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like. | 02-27-2014 |
| 20160060253 | METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG - The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R | 03-03-2016 |
