| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548335100 | Two double bonds between ring members of the diazole ring (i.e., imidazole) | 80 |
| 20080227987 | Process for the Preparation of Onium Alkylsulfites - The invention relates to a process for the preparation of onium alkylsulfites by reaction of an onium halide or carboxylate with a symmetrically substituted dialkyl sulfite or with an asymmetrically substituted dialkyl sulfite at temperatures of 0 to 70° C. | 09-18-2008 |
| 20080275252 | Atipamezole Hydrochloride Crystallization Method - A method of isolating atipamezole hydrochloride as a crystalline salt is provided. | 11-06-2008 |
| 20080287684 | Method for Producing Ionic Liquids - The present invention describes a process for preparing ionic liquids (I) by reacting ionic liquids (II) whose anion is a halide with an acid (III), with the resulting hydrogen halide being scavenged by means of an amine and the resulting ammonium halide being able to be separated off. | 11-20-2008 |
| 20090023933 | METHOD FOR ISOLATING ACIDS FROM CHEMICAL REACTION MIXTURES BY USING 1-ALKYLIMIDAZOLES - Method of separating acids from reaction mixtures by means of an auxiliary base, where the auxiliary base
| 01-22-2009 |
| 20090171098 | Heteroaryl Salts and Methods For Producing and Using the Same - The invention provides heteroaryl salts and methods for producing the same. In particular, the invention provides heteroaryl salts of the formula: | 07-02-2009 |
| 20090281329 | Removing hydrocarbon impurities from acetic acid by ionic liquid extraction - A method for removing hydrocarbon impurities from acetic acid is disclosed. The method comprises extracting acetic acid with a hydrophilic imidazolium salt. The imidazolium salt preferably has the general structure of | 11-12-2009 |
| 20100004461 | COMPOUNDS CONTAINING ORGANOFLUOROCHLOROPHOSPHATE ANIONS - The present invention relates to compounds containing organofluorochlorophosphate anions, the preparation thereof and the use thereof, in particular as ionic liquids. | 01-07-2010 |
| 20100113800 | Formation of Carbon-nitrogen bond - The present invention relates to a process to create a carbon-nitrogen bond by the reaction of an aromatic compound carrying at least one electro attractive group with one nitrogenous heterocyclic type nucleophile compound. The invention aims, in particular, at a link reaction between an aromatic compound carrying at least one electro attractive group and an imidazole heterocycle type. The invention process, consisting of the reaction of an aromatic compound carrying one leaving group and at least one electro attractive group and a nitrogenous heterocyclic type nucleophile compound comprising a N—H pattern likely to substitute the leaving group, thereby creating a carbon-nitrogen bond in the presence of a copper catalyst, of a base in an organic solvent, is characterized by the fact that the said nitrogenous heterocycle reacts with an aromatic type electrophile compound carrying one leaving group (Y) chosen from bromine, chlorine or sulfonic ester and at least one electro attractive group (Z1), in the presence of a copper catalyst, of a mineral or organic base, of an extracting agent selected from aliphatic diamines, aliphatic amino alcohols and diols in a polar aprotic organic solvent with a dielectric constant less than about 20 and a basicity such that its “donor number” is less than about 25. | 05-06-2010 |
| 20100121075 | ALKYL H-PHOSPHONATES OF N,N'-DIALKYLIMIDAZOLIUMS AND OF QUATERNARY AMMONIUMS AND USES THEREOF - The application relates to the use of a salt associating an ammonium cation with an alkyl H-phosphonate anion of the following formula (I) in which R is a hydrocarbon radical, the pointed bond can be present or not, the radical R | 05-13-2010 |
| 20100217010 | PROCESS FOR PREPARING IONIC LIQUIDS BY ANION EXCHANGE - Process for preparing salts of the formula I | 08-26-2010 |
| 20100249432 | METHOD FOR THE PRODUCTION OF DISUBSTITUTED IMIDAZOLIUM SALTS - Process for preparing 1,3-disubstituted imidazolium salts of the formula I | 09-30-2010 |
| 20110152537 | IONIC LIQUIDS - The present invention relates to chemical compounds comprising a [Y(CHR | 06-23-2011 |
| 20110319633 | FOAMED IONIC COMPOUNDS - Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications. | 12-29-2011 |
| 20120088920 | CLATHRATE COMPOUND, CURING CATALYST, COMPOSITION FOR FORMING CURED RESIN, AND CURED RESIN - A curing catalyst (clathrate compound) for which the curing reaction is suppressed at low temperatures, allowing an improvement in the one-pot stability, but which can effectively cure a resin upon heat treatment. The clathrate compound includes at least an isophthalic acid compound represented by Formula (I), where R | 04-12-2012 |
| 20120116096 | Method of Dehydrating An Ionic Liquid - A method of impeding water input in an ionic liquid is provided, wherein the method comprises adding an additive to the ionic liquid wherein the additive comprises an orthoester. In particular, at least some residues of the additive may remain or may be present in the ionic liquid during the usage of the ionic liquid. For example, the additive may be formed by the orthoester or by a mixture of orthoesters. | 05-10-2012 |
| 20120123131 | PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE - The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. | 05-17-2012 |
| 20120136161 | Method of Synthesizing Organic Molecules - A method of synthesizing organic molecules is provided, wherein the method comprises providing an electrophilic educt, providing an ionic liquid comprising a carbanion, and synthesizing the organic molecules by mixing the electrophilic educt and the ionic liquid. | 05-31-2012 |
| 20120142938 | Non-halogen activating agent used as flux - A non-halogen active agent for a flux is a sulfonate formed by a sulfonic acid reacting with an organic base. The sulfonic acid can be an alkyl sulfonic acid, alkyl disulfonic acid, hydroxyl sulfonic acid or halogenated sulfonic acid. The organic base can be an organic amine, carbamidine, imidazole, phosphorus. The non-halogen active agent for a flux has the advantage of high activity and low corrosion. | 06-07-2012 |
| 20120157688 | IMIDAZOLIUM MONOCARBOXYLATE SALT AND METHOD FOR PREPARATION THEREOF - Imidazolium monocarboxylate salt compositions are suitable for use as latent catalysts in curable epoxy compositions. The curable compositions prepared therefrom are used to prepare coated substrates, and to produce conformally sealed printed wiring boards. Method for preparation and curing are also provided. Of particular utility are compositions comprising 2-ethyl-4-methyl imidazolium monocarboxylate salts. | 06-21-2012 |
| 20120238764 | PROCESS FOR PREPARING IONIC LIQUIDS BY ANION EXCHANGE - Process for preparing salts K | 09-20-2012 |
| 20130041159 | PROCESS FOR PURIFYING IONIC LIQUIDS - The present process purifies a salt Cat | 02-14-2013 |
| 20130053575 | CATALYST COMPOSITION AND METHOD FOR PREPARING AMIDE - The present invention provides a catalyst composition and a method for preparing an amide. The catalyst composition of the present invention including a hydroxylamine salt, sulfuric acid, and a nitrogen-containing heterocyclic compound is used for catalyzing a ketoxime to form an amide in the Beckman rearrangement reaction. The preparation of an amide by using the catalyst composition of the present invention has high conversion rate of a ketoxime, high selectivity of an amide and high tolerance to water. | 02-28-2013 |
| 20130274480 | MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF - The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases. | 10-17-2013 |
| 20160168437 | PROPELLANT ISOLATION BARRIER | 06-16-2016 |
| 20160185732 | METHOD AND INDUSTRIAL PROCESS FOR CONTINUOUS SYNTHESIS OF DIFFERENT IONIC LIQUIDS - Producing different ionic liquids industrially currently requires either operating separate plants or continually refitting existing plants. While this is not laborious, it is often not economical either. The problem the present invention addresses is that of describing a method and an industrial process by which different ionic liquids can be produced almost synchronously in a unitary production sequence. This is done either by using a chemical intermediate both relatively simple to prepare and readily convertible into multiple products, or by preparing the desired products in the same industrial process by direct synthesis from the appropriate starting materials. The method described here allows the synthesis of different ionic liquids in excellent yields and grades in a unitary production operation. | 06-30-2016 |
| 548335500 | Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding | 30 |
| 20080200691 | Process For the Synthesis of Organic Compounds - The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 08-21-2008 |
| 20080249316 | CRYSTALLINE FORMS OF [3-(4- -PHENOXY)-PROPYL]-DIETHYL-AMINE - The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE mediated diseases. | 10-09-2008 |
| 20100280257 | PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS - The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 11-04-2010 |
| 20110166361 | CRYSTALLINE FORMS OF [3-(4- -PHENOXY)-PROPYL]-DIETHYL-AMINE - The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE mediated diseases. | 07-07-2011 |
| 20120022269 | FLUORINE-CONTAINING N-ALKYLSULFONYLIMIDE COMPOUND, MANUFACTURING METHOD THEREFOR, AND METHOD OF MANUFACTURING AN IONIC COMPOUND - According to the method for producing fluorine-containing N-alkylsulfonylimide compound, the fluorine-containing N-alkylsulfonylimide compound can be produced safely with a high recovery rate by alkylating fluorine-containing sulfonylimide acid or fluorine-containing sulfonylimide acid salt with dialkylsulfuric acid or dialkylcarbonic acid. | 01-26-2012 |
| 20150011778 | USE OF TRIFLUOROACETAMIDE FOR N-TERMINAL PROTECTION - This disclosure teaches the novel use of trifluoroacetamide for N-terminal protection. The disclosure also teaches novel compositions and chemical structures associated therewith. These methods and compositions are useful for site-specific methylation of peptide backbone amides, performed, for example, to modulate the pharmacokinetic properties of peptide drugs. | 01-08-2015 |
| 548336100 | The nitrogen is multiply bonded to carbon | 5 |
| 20110071303 | METHODS OF PREPARING IMIDAZOLE-BASED COMPOUNDS - Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I: | 03-24-2011 |
| 20140275569 | METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION - The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under superheated conditions in either a microwave or oil bath. | 09-18-2014 |
| 20150126746 | SALT OF BICYCLIC AROMATIC ANIONS FOR LI-ION BATTERIES - A method for obtaining salts of bicyclic imidazole compounds (V) having general structural formulae in which A represents a monovalent cation, X represents independently a carbon atom, an oxygen atom, a sulphur atom or a nitrogen atom. Also, the associated production method and to the use thereof, in particular as an electrolyte component for batteries. | 05-07-2015 |
| 548337100 | The nitrogen is part of a -C=N group which is bonded directly to the diazole ring (e.g., 4,5-dicyanoimidazole, etc.) | 2 |
| 20080262241 | Methods of Preparing Imidazole-Based Compounds - Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I: | 10-23-2008 |
| 20080293951 | Amin Derivative, and Production Method and Use Thereof - Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for producing such a benzonitrile derivative and a use thereof as a bactericide. Specifically disclosed are a novel benzonitrile derivative represented by the general formula (1) below, a salt thereof, a production method thereof, and a use thereof as a pharmaceutical intermediate or a bactericide. [Chemical formula 1] (5) (In the formula, n represents an integer of 0-3, and R | 11-27-2008 |
| 548338100 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the nitrogen | 12 |
| 20080306280 | Novel process for the preparation of phenylcarbamates - This invention relates to a process for the preparation of an aminoalkyl phenyl carbamate compound of formula 1, | 12-11-2008 |
| 20090012306 | Cationic Amino Acid Type Lipid - The present invention provides a novel complex lipid having a cationic functional group derived from an amino acid. Namely, the present invention provides a cationic acid amino acid type lipid represented by the following formula: | 01-08-2009 |
| 20090149658 | Novel Histidine Derivatives - The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention is very useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases. | 06-11-2009 |
| 20090299075 | PROCESS FOR PRODUCING MUSCARINE RECEPTOR ANTAGONIST AND INTERMEDIATE THEREFOR - The industrial production of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide, a urinary incontinence remedy, necessitates elimination of problems concerning the use of a synthetic adsorbent, e.g., HP-20, the efficiency of operation with the same, purification efficiency, etc. An acid salt, e.g., hydrochloride or phosphate, of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide or a hydrate of any of these salts is used as an intermediate. This intermediate is neutralized and then purified. Thus, high-purity 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide is easily obtained in satisfactory yield. The industrial-scale production process has been thus established. | 12-03-2009 |
| 20100036132 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS - The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders. | 02-11-2010 |
| 20100152459 | NOVEL HISTIDINE DERIVATIVES - The present invention is to provide a novel compound which is useful as a pharmaceutical agent such as an analgesic. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention has a very high intermigration into the blood upon oral administration and is very useful as a pharmaceutical agent, especially an analgesic for the treatment of acute or chronic pain diseases and of neuropathic pain diseases. | 06-17-2010 |
| 20100267962 | N-ACYLIC AMINOACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACOLOGICAL COMPOSITION AND THE USE IN THE FORM ANTI-ALLERGIC, ANTI-INFLAMMATORY AND HYPOLIPIDEMIC AGENTS - The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof | 10-21-2010 |
| 20110201824 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY - This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl-imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxicity relative to existing imidazolium bases ILs such as 1-butyl-3-methylimidazolium (bmmim) salts. Many of the described ILs produce a score of over 60% biodegradability over 28 days in a biodegradability test such as the Sturm Test, the Closed Bottle Test (OECD 301D) or the CO | 08-18-2011 |
| 20110263868 | NOVEL CRYSTALS AND PROCESS OF MAKING 5-(-METHYL)-2-METHOXY-BENZOIC ACID - The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. | 10-27-2011 |
| 20130096315 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 04-18-2013 |
| 20130109866 | AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS | 05-02-2013 |
| 20140094614 | AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS - The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor. | 04-03-2014 |
| 548339100 | The nitrogen and -C(=X)X-, wherein X`s are the same or diverse chalcogens, are bonded directly to the same acyclic carbon atom (e.g., -amino-4(5)- imidazole propionic acid or histidine, etc.) | 2 |
| 20100056799 | Stable Isotope-Labeled Aromatic Amino Acids, Method for Incorporating the Same in Target Protein and Method for NMR-Structural Analysis of Proteins - The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is | 03-04-2010 |
| 20120226051 | ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF - Organic dicarboxylic acid compounds, salts and preparation methods thereof. The said compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as formula (1). | 09-06-2012 |
| 20100056799 | Stable Isotope-Labeled Aromatic Amino Acids, Method for Incorporating the Same in Target Protein and Method for NMR-Structural Analysis of Proteins - The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is | 03-04-2010 |
| 20120226051 | ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF - Organic dicarboxylic acid compounds, salts and preparation methods thereof. The said compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as formula (1). | 09-06-2012 |
| 548340100 | Chalcogen attached indirectly to the nitrogen by acyclic nonionic bonding | 3 |
| 20090012307 | Process for the Preparation of 4-(imidazol-1-yl)benzenesulfonamide Derivatives - Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives of formula I, wherein R | 01-08-2009 |
| 20090312559 | CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES - The present invention provides methods, compositions and systems for silylation of substrates, including direct asymmetric silylation of a substrate to provide enantiomerically enriched silylated products. | 12-17-2009 |
| 20110009641 | Amine-containing lipids and uses thereof - Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 01-13-2011 |
| 548339100 | The nitrogen and -C(=X)X-, wherein Xs are the same or diverse chalcogens, are bonded directly to the same acyclic carbon atom (e.g., -amino-4(5)- imidazole propionic acid or histidine, etc.) | 2 |
| 20100056799 | Stable Isotope-Labeled Aromatic Amino Acids, Method for Incorporating the Same in Target Protein and Method for NMR-Structural Analysis of Proteins - The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is | 03-04-2010 |
| 20120226051 | ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF - Organic dicarboxylic acid compounds, salts and preparation methods thereof. The said compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as formula (1). | 09-06-2012 |
| 20100056799 | Stable Isotope-Labeled Aromatic Amino Acids, Method for Incorporating the Same in Target Protein and Method for NMR-Structural Analysis of Proteins - The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is | 03-04-2010 |
| 20120226051 | ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF - Organic dicarboxylic acid compounds, salts and preparation methods thereof. The said compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as formula (1). | 09-06-2012 |
| 548341100 | Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding | 11 |
| 20100105922 | PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME - The present invention provides an industrially advantageous process for producing a steroid C | 04-29-2010 |
| 20100197935 | CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT - A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises. | 08-05-2010 |
| 20140012012 | POLYETHER COMPOUND AND ELECTROLYTE COMPOSITION - A polyether compound containing oxirane monomer units in an average number per molecule of | 01-09-2014 |
| 548341500 | The chalcogen, X, is in a -C(=X)- group | 7 |
| 20080200692 | Process For the Synthesis of Organic Compounds - The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 08-21-2008 |
| 20100004462 | PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N-HYDROXYALKYLATED IMIDAZOLES - A process for preparing (meth)acrylic esters (F) of N-hydroxyalkylated imidazoles, wherein N-hydroxyalkylated imidazoles (I), | 01-07-2010 |
| 20100240906 | 1-PHENYL-1H-PYRAZOLE-BASED COMPOUNDS - Methods useful for preparing compounds of formula I: | 09-23-2010 |
| 20110028733 | PROCESS FOR THE PREPARATION OF 5-(2-ETHYL-DIHYDRO-1H-INDEN-2-YL)-1H-IMIDAZOLE AND SALTS THEREOF - The invention provides an improved, highly efficient method for preparing 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole, and its salts, in particular its pharmaceutically acceptable salts. | 02-03-2011 |
| 20120116097 | PROCESS FOR PREPARING HETEROAROMATIC RING COMPOUND HAVING N-Rf GROUP - There is provided a preparation process in which a N—H group of a heteroaromatic ring compound having a N—H group in its ring is converted directly to a N—Rf group at a high reaction efficiency without using a catalyst. The preparation process is a process for preparing a compound comprising a heteroaromatic ring structure having a N—Rf group (—Rf is a fluorine-containing organic group) in its ring and is characterized in that the heteroaromatic ring compound having a N—H group in its ring is allowed to react with fluoroalkene in the absence of an alkali metal. | 05-10-2012 |
| 20130018194 | OCTAHYDROBINAPHTHOL DERIVATIVE FOR L/D OPTICAL CONVERSION AND OPTICAL RESOLUTIONAANM Kim; Kwan-MookAACI SeoulAACO KRAAGP Kim; Kwan-Mook Seoul KR - This invention relates to octahydro-binaphthol derivatives, which can recognize amino acids and amino alcohols enantioselectively and transform L-amino acids into D-amino acids and optically resolve amino acids or amino alcohol with high efficiency. | 01-17-2013 |
| 20140135503 | NOVEL PROCESSES FOR THE PREPARATION OF PROSTAGLANDIN AMIDES - The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R | 05-15-2014 |
| 548342500 | Benzene ring or halogen attached directly to the diazole ring by nonionic bonding (e.g., 1-hydroxyethyl-4,5-diphenyl-imidazole; 1-ethyloxymethyl-2, 4,5-trichloro-imidazole, etc.) | 1 |
| 20180022675 | PRODUCTION METHOD FOR INCLUSION COMPOUND | 01-25-2018 |
| 548343100 | Halogen attached directly or indirectly to the diazole ring by acyclic nonionic bonding | 2 |
| 20100222598 | PROCESS FOR PREPARING HETEROAROMATIC RING COMPOUND HAVING N-Rf GROUP - There is provided a preparation process in which a N—H group of a heteroaromatic ring compound having a N—H group in its ring is converted directly to a N—Rf group at a high reaction efficiency without using a catalyst. The preparation process is a process for preparing a compound comprising a heteroaromatic ring structure having a N—Rf group (—Rf is a fluorine-containing organic group) in its ring and is characterized in that the heteroaromatic ring compound having a N—H group in its ring is allowed to react with fluoroalkene in the absence of an alkali metal. | 09-02-2010 |
| 20100331551 | ALPHA-HALOKETONE DERIVATIVES OF IMIDAZOLYL-SUBSTITUTED AROMATIC COMPOUNDS AND COMPOUNDS PREPARED THEREFROM - Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. | 12-30-2010 |
| 548343500 | Benzene ring bonded directly to the diazole ring | 6 |
| 20140323740 | IDO Inhibitors - Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R | 10-30-2014 |
| 20150025250 | CYSTEINE PROTEASE INHIBITORS - Compounds of the formula I | 01-22-2015 |
| 20150329494 | Process for Preparing Asymmetrical Imidazolium Salts - The invention relates to a process for preparing an asymmetrical imidazolium salt of formula (1A), in which R1 is an aromatic group, R2 is chosen from a cyclic secondary aliphatic alkyl group and a heteroalkyl group, R3 and R4 are chosen, independently of one another, from the group consisting of hydrogen, a halide and an alkyl group, and A″ is an anion. The process comprises a fast substep of forming a reaction mixture by bringing one equivalent of an aniline into contact with one equivalent of a compound bearing an amine group, in the presence of at least four point five equivalents of a Brønsted acid. The process also comprises a second substep of forming a solution comprising one equivalent of a dicarbonyl, one equivalent of formaldehyde, and at least four point five equivalents of the Brønsted acid, and adding thereto the reaction mixture formed in the first substep. The mixture is left to stir for a predetermined time at a predetermined temperature. The intermediate asymmetrical imidazolium salt 1A is then isolated. | 11-19-2015 |
| 20150361049 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR - A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R | 12-17-2015 |
| 20170233350 | PROCESSES FOR PREPARING ASK1 INHIBITORS | 08-17-2017 |
| 20180022708 | PROCESSES FOR PREPARING ASK1 INHIBITORS | 01-25-2018 |
| 548345100 | Cycloaliphatic ring bonded directly to the diazole ring | 1 |
| 20120130084 | PREPARATION OF FIPAMEZOLE - The application relates to processes for preparing fipamezole and its pharmaceutically acceptable salts, and intermediates thereof. It also provides intermediate compounds of Formula III and Formula IV, and processes for their preparation. | 05-24-2012 |
| 548346100 | Benzene ring attached indirectly to the diazole ring by acyclic nonionic bonding | 5 |
| 20080287685 | Detomidine Hydrochloride Crystallization Method - A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with | 11-20-2008 |
| 20100048915 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. - The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde. | 02-25-2010 |
| 20130225832 | PROCESS FOR THE RESOLUTION OF MEDETOMIDINE AND RECOVERY OF THE UNWANTED ENANTIOMER - A new and efficient process to obtain Medetomidine enantiomers, a selective and potent α2-receptor agonist, is presented. Such process comprises a resolution step and a racemisation reaction, to be able to recover the unwanted enantiomer which can be recycled as starting material. | 08-29-2013 |
| 20140187789 | NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES - There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves. | 07-03-2014 |
| 20150057453 | METHOD FOR PREPARATION OF MEDETOMIDINE - The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton. | 02-26-2015 |
