| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548182000 | Chalcogen bonded directly to ring carbon of the thiazole ring | 23 |
| 20090137817 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY - Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 05-28-2009 |
| 20100145063 | 2- thioethenyl substituted carbapenem derivatives - 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant | 06-10-2010 |
| 548183000 | Plural chalcogens bonded directly to ring carbons of the thiazole ring | 7 |
| 20080293949 | Novel heterocyclic analogs of diphenylethylene compounds - Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis. | 11-27-2008 |
| 20090023929 | Intermediate of 6-Substituted 1-Methyl-1-H-Benzimidazole Derivative and Method for Producing Same - A method for preparing a compound having the following formula (I) | 01-22-2009 |
| 20100222596 | KIND OF ORGANIC COMPOUND AND ORGANIC DYE USED IN DYE-SENSITIZED SOLAR CELL THEREOF - A kind of organic compound and organic dye used in dye-sensitized solar cell thereof. In the present invention, we synthesize a series of novel organic compounds with the structure of donor-conjugated chain-acceptor (D-π-A). The electron donor and acceptor groups, for example, are arylamine and cyanoacrylic acid, respectively. These novel organic compounds can be applied to the material of dye layer in the dye-sensitized solar cell (DSSC). | 09-02-2010 |
| 20100234612 | Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same - A compound having the following formula (III) | 09-16-2010 |
| 20110160462 | CRYSTALLINE FORMS OF THIAZOLIDINEDIONE COMPOUND AND ITS MANUFACTURING METHOD - Thiazolidinedione compound crystalline forms useful as a bulk material for the manufacture of a peroxisome proliferator-activated receptor (PPAR) γ activator or an anticancer pharmaceutical composition are provided, which are hydrate crystalline forms of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimi dazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione represented by Formula (I) below and of its dihydrochloride. | 06-30-2011 |
| 20130204008 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 08-08-2013 |
| 20150051406 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES - The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease). | 02-19-2015 |
| 548184000 | Nitrogen attached directly to the thiazole ring by nonionic bonding | 9 |
| 20100280255 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein. | 11-04-2010 |
| 20100317867 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES - The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), said derivatives being described in WO 2005/054215. These compounds of General Formula (II) are described in WO 2005/054215 to act as immunosuppressive agents. | 12-16-2010 |
| 20110160463 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R | 06-30-2011 |
| 20110178307 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts. | 07-21-2011 |
| 20120302758 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES - The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), said derivatives being described in WO 2005/054215. These compounds of General Formula (II) are described in WO 2005/054215 to act as immunosuppressive agents. | 11-29-2012 |
| 20130345432 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts. | 12-26-2013 |
| 20140316140 | DOSING REGIMEN FOR A SELECTIVE S1P1 AGONIST - The present invention relates to a dosing regimen for a selective S1P | 10-23-2014 |
| 20150336912 | (4E)-4-(4-SUBSTITUTED BENZYLIDENEAMINO)-2,3-DIHYDRO-3-SUBSTITUTED-2-THIOXOTHIAZOLE-5-CARBONITRI- LES AS A2AR ANTAGONIST AND PROCESS FOR PREPARATION THEREOF - The present invention provides (4E)-4-(4-substituted benzylideneamino)-2,3-dihydro-3-substituted-2-thioxothiazole-5-carbonitriles of general formula A, below, and a process for the preparation thereof. | 11-26-2015 |
| 548185000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to nitrogen | 1 |
| 20090176991 | BENZAMIDE GLUCOKINASE ACTIVATORS - The present invention relates to N-heteroaryl-benzamides of the formula (I), pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful as glucokinase activators. | 07-09-2009 |
| 548186000 | Chalcogen attached indirectly to the thiazole ring by nonionic bonding | 4 |
| 20110237803 | Process - A process for preparing the S or R enantiomer of a compound of formula A, | 09-29-2011 |
| 548187000 | The chalcogen, X, is in a -C(=X)- group | 3 |
| 548188000 | The -C(=X)- group is bonded directly to the thiazole ring | 3 |
| 20080269498 | THERAPEUTIC SUBSTITUTED LACTAMS - Therapeutic compounds, compositions, medicaments, and methods are disclosed herein. | 10-30-2008 |
| 20080287683 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES - The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compounds of 3,4-disubstituted-thiazolidin-2-ones. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds (such as latrunculins and/or their analogs) for treating diseases or conditions associated with inhibiting actin polymerization. | 11-20-2008 |
| 20160083341 | METHOD FOR PRODUCING a-SUBSTITUTED CYSTEINE OR SALT THEREOF OR SYNTHETIC INTERMEDIATE OF a-SUBSTITUTED CYSTEINE - According to the present invention, it becomes possible to perform a process for converting into an α-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance. In the production of an α-substituted-D-cysteine or a salt thereof, it becomes possible to perform a process for converting the compound represented by general formula (2) into a compound represented by general formula (3S) in one step by allowing an enzyme or the like to act on the compound represented by general formula (2). | 03-24-2016 |
| 548189000 | Nitrogen attached indirectly to the thiazole ring by nonionic bonding | 1 |
| 20160016943 | BENZOTHIAZOLE DERIVATIVES AND A USE THEREOF FOR THE TREATMENT OF CANCER - Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: | 01-21-2016 |
