| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546314000 | Carbonyl bonded directly to the six-membered hetero ring | 77 |
| 20090247763 | FUNGICIDAL COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES - It is to provide a fungicidal composition having stable and high fungicidal effects against cultivated crops infected with plant diseases resulting from plant diseases. | 10-01-2009 |
| 20120232279 | Mild and Selective Vanadium-Catalyzed Oxidation of Benzylic, Allylic, and Propargylic Alcohols Using Air - The invention concerns processes for oxidizing an alcohol to produce a carbonyl compound. The processes comprise contacting the alcohol with (i) a gaseous mixture comprising oxygen; and (ii) an amine compound in the presence of a catalyst, having the formula: | 09-13-2012 |
| 20120232280 | DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALKANONE AND USE THEREOF AS p75 INHIBITORS - The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): | 09-13-2012 |
| 20120323014 | METHOD FOR PRODUCING ALPHA-ACYLOXYCARBONYL COMPOUND AND NOVEL ALPHA-ACYLOXYCARBONYL COMPOUND - A method for producing an α-acyloxycarbonyl compound of the present invention includes performing an intermolecular reaction between a carboxylic acid and a carbonyl compound selected from the group consisting of ketones, aldehydes, and esters, which have a hydrogen atom at the α-position, using a hydroperoxide as an oxidizer and an iodide salt as a catalyst precursor, thereby introducing an acyloxy group derived from the carboxylic acid into the α-position of the carbonyl compound. | 12-20-2012 |
| 20130204004 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 08-08-2013 |
| 20130211095 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 08-15-2013 |
| 20140018542 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 01-16-2014 |
| 546315000 | At 3-position | 43 |
| 20080255364 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof - Process for preparing unsubstituted or nuclear-substituted α-chloroalkyl pyridyl ketones and/or their hydrochlorides by reacting the corresponding unsubstituted or nuclear-substituted alkyl pyridyl ketone hydrochlorides with sulfuryl chloride at a reaction temperature of from −25 to 70° C. (248 to 343 K) and a pressure of 0.05 to 0.2 MPa abs, in which the reaction is carried out in the presence of an unbranched or branched C | 10-16-2008 |
| 20090221832 | PROCESS FOR PREPARING KETONES FROM ALPHA-OXO CARBOXYLATES AND ARYL BROMIDES - A process for preparing ketones of the general formula (III) | 09-03-2009 |
| 20110288302 | Catalyst Coated Honeycomb Substrates and Methods of Using Them - An essentially nonporous honeycomb substrate having greater than 900 cells per square inch and with a catalyst coating having a thickness less than 1 micron. The coated essentially nonporous honeycomb may be used, for example, for gas phase reactions. | 11-24-2011 |
| 20120232281 | PROCESS FOR PREPARING 1-(6-METHYLPYRIDIN-3-YL)-2-[4-(METHYLSULFONYL)PHENYL]ETHANONE, AN INTERMEDIATE OF ETORICOXIB - A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described. | 09-13-2012 |
| 20150133671 | The Process For Preparing a Ketosulfone Derivative - The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative. | 05-14-2015 |
| 546316000 | Acyclic nitrogen bonded directly to the carbonyl | 11 |
| 20110003999 | Process for Preparing Substituted Biphenylanilides - The present invention relates to a process for preparing substituted biphenylanilides of the formula I | 01-06-2011 |
| 20110054183 | Method For Manufacturing Aryl Carboxamides - A process for preparing arylcarboxamides of the formula (I) | 03-03-2011 |
| 20110105760 | Method for Producing Aminobiphenylene - The present invention relates to a process for preparing substituted 2-aminobiphenyls and to a process for preparing (Het)arylamides of such 2-aminobiphenyls. | 05-05-2011 |
| 20120116090 | Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements. | 05-10-2012 |
| 20120149910 | Pesticidal Carboxamides - The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I): | 06-14-2012 |
| 20130338369 | Process for the Synthesis of Aminobiphenylene - The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions. | 12-19-2013 |
| 20140323736 | USE OF ARYL AND HETARYL CARBOXAMIDES AS ENDOPARASITICIDES - The present application relates to known and novel aryl- and hetarylcarboxamides of the formula (I) | 10-30-2014 |
| 20190144392 | PROCESS FOR PREPARING BOSCALID | 05-16-2019 |
| 546317000 | Processes of obtaining nicotinamide per se | 3 |
| 20120022262 | PROCESS OF HYDROLYSIS OF HETEROAROMATIC NITRILS IN AQUEOUS FLUIDS - The present invention relates to a process for the hydrolysis of nitriles of the formulae | 01-26-2012 |
| 20130123505 | METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE - A carboxamide can be produced in a high yield by a method for producing a carboxamide, for example, represented by formula (4): | 05-16-2013 |
| 20140081029 | Catalytic Process for Production of Pyridine Carboxylic Acid Amides - An improved catalytic process for the production of pyridine carboxylic acid amides, by catalytic hydration reaction of pyridine nitriles with solid heterogeneous catalyst wherein the process involve effective utilization and recycling of the catalytic components, and reactants. | 03-20-2014 |
| 546318000 | The carbonyl is in a -COO- group | 27 |
| 20080200685 | Method for Preforming Oxidation Catalysts - Processes comprising providing a catalyst precursor, and heating the catalyst precursor to a temperature of at least 350° C. in an atmosphere comprising air, wherein air is fed into the atmosphere at a rate of 0.05 to 4.0 standard m | 08-21-2008 |
| 20080312450 | Method for Start-Up of Oxidation Catalysts - Methods comprising: providing an oxidation catalyst bed; and starting up the oxidation catalyst at a temperature of 360° C. to 400° C. with an amount of air of 1.0 to 3.5 standard m | 12-18-2008 |
| 20100168435 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES - 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield. | 07-01-2010 |
| 20100240899 | INTERMEDIATE RELEASE NICOTINIC ACID COMPOSITIONS FOR TREATING HYPERLIPIDEMIA WHICH EXHIBIT AN IN VIVO STAIR-STEPPED ABSORPTION CURVE - Intermediate release nicotinic acid formulations exhibiting an in vivo stair-stepped or sigmoidally-shaped absorption curves when the plasma nicotinic acid or nicotinuric acid curves are deconvoluted using the Wagner-Nelson method, which are suitable for oral administration once-a-day preferably during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued, are disclosed. The stair-stepped or sigmoidal-shaped absorption profiles for nicotinic acid or nicotinuric acid absorbed from the nicotinic acid formulations of the instant invention are characterized by three phases and by the fact that significant quantities of nicotinic acid are absorbed during the first two phases. The first phase generally ends at about 2.3 hours following ingestion and the second phase generally ends at about 7.3 hours after consumption. Approximately 6% of the nicotinic acid dose is generally absorbed by the end of the first phase and approximately 91% of the nicotinic acid dose is absorbed by the end of the second phase. | 09-23-2010 |
| 20120157685 | INTERMEDIATE RELEASE NICOTINIC ACID COMPOSITIONS FOR TREATING HYPERLIPIDEMIA WHICH EXHIBIT AN IN VIVO STAIR-STEPPED ABSORPTION CURVE - Intermediate release nicotinic acid formulations are described herein exhibiting an in vivo stair-stepped or sigmoidally-shaped absorption curves when the plasma nicotinic acid or nicotinuric acid curves are deconvoluted using the Wagner-Nelson method, which are suitable for oral administration once-a-day preferably during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued. | 06-21-2012 |
| 20150353490 | SALTS OF SAXAGLIPTIN WITH ORGANIC ACIDS - The invention relates to organic salts of Saxagliptin and processes for their preparation. | 12-10-2015 |
| 546321000 | Additional -COO- group bonded directly to the six-membered hetero ring | 17 |
| 20080242867 | ACETONE SOLVATE OF PHTHALOYL AMLODIPINE - An acetone solvate of phthaloyl amlodipine, as well as a process for its preparation including dissolving phthaloyl amlodipine in acetone and cooling the mixture. The present invention also comprises a method for the synthesis of amlodipine, its salts or solvates, which comprises the use of an acetone solvate of phthaloyl amlodipine. | 10-02-2008 |
| 20080249314 | Optical Resolution Method of Amlodipine - The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)— or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)— or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine. | 10-09-2008 |
| 20080262239 | Process for Producing Enantiomer of Amlodipine in High Optical Purity - The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution. | 10-23-2008 |
| 20080306277 | Process for Preparation of Chiral Amlodipine Gentisate - The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic (R,S)-amlodipine and optically pure O,O′-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare (R)- or (S)-amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid. | 12-11-2008 |
| 20090221833 | Polymorphic Form of Lercanidipine Hydrochloride and Process for the Preparation Thereof - Processes for the purification of lercanidipine hydrochloride are provided which uses a binary system of an alcohol-containing solvent such as methanol and an aliphatic ester-containing solvent such as isopropyl acetate. Processes for the preparation of substantially amorphous lercanidipine hydrochloride are also provided. Also provided is lercanidipine hydrochloride substantially in polymorph form V. | 09-03-2009 |
| 20090326234 | (S)-(-)-Amlodipine Camsylate or Hydrate Thereof And Pharmaceutical Composition Comprising Same - Disclosed is (S)-(−)-amlodipine camsylate or a hydrate thereof having good photostability and high solubility, and a pharmaceutical composition comprising same, which can be efficiently used in treating cardiovascular diseases. | 12-31-2009 |
| 20100069642 | CRYSTALLINE S-(-)-AMLODIPINE ADIPIC ACID SALT ANHYDROUS AND PREPARATION METHOD THEREOF - Disclosed are crystalline S-(−)-amlodipine adipic acid salt anhydrous and a preparation method thereof. The crystalline S-(−)-amlodipine adipic acid salt anhydrous exhibits excellent physical and chemical properties including non-hygroscopicity, solubility, thermal stability, and photostability, and is superior in formulation processability and long-term storage safety. | 03-18-2010 |
| 20100087653 | NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE - The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropy1)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropy1)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride. | 04-08-2010 |
| 20100099884 | METHOD OF PREPARING S-(-)-AMLODIPINE OR A SALT THEREOF AND AN INTERMEDIATE USED THEREIN - The present invention provides a novel method for preparing S-(−)-amlodipine having a high optical purity or a salt thereof and an intermediate used therein. | 04-22-2010 |
| 20110021783 | PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY - The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution. | 01-27-2011 |
| 20110040097 | PROCESS FOR PREPARING LERCANIDIPINE HYDROCHLORIDE - Disclosed herein is a novel method for preparing lercanidipine hydrochloride which is highly effective for treating hypertension. The method comprises the steps of reacting 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with a substituted chlorophosphate derivative to obtain a substituted phosphonoester derivative, and reacting the substituted phosphonoester derivative with 2, N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol. According to the preparation method, since little by-products are formed, the yield is improved, as compared to cases of conventional methods. In addition, the method involves simple isolation and purification processes of lercanidipine, thus realizing a high-quality product. Furthermore, the method has advantages of low preparation costs, substantial waste-free environmental-friendly process and applicability to industrial mass-production. | 02-17-2011 |
| 20110275825 | PREPARATION OF DIHYDROPYRIDINES - The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them. | 11-10-2011 |
| 20120108818 | MICROWAVE APPARATUS - The present invention relates to a microwave apparatus, a method or use of the apparatus and a method of carrying out chemical reactions on a continuous basis with the apparatus, wherein the apparatus is particularly suitable for microwave-assisted organic synthesis. | 05-03-2012 |
| 20130053573 | 2,4,5-TRIAMINOPHENOLS AND RELATED COMPOUNDS - New triaminophenol compositions and related compounds are disclosed, as are processes for their preparation and for the preparation of novel salts and diacid complexes from such compounds. Polymers prepared from these compositions can be made into high strength fiber, film, and tape and are useful in applications such as protective apparel, aircraft, automotive components, personal electronics, and sports equipment. | 02-28-2013 |
| 20140031557 | METHOD FOR PURIFICATION OF CALCIUM CHANNEL BLOCKERS OF DIHYDORPYRIDINE TYPE AND PREPARATION OF NANOPARTICLES THEREOF - A method for purification calcium ion channel blocker medicament of dihydropyridine type and pharmaceutically acceptable salts thereof through the ultrasonic crystallization technology and direct preparation of nanoparticles thereof. | 01-30-2014 |
| 20150335628 | OLIGOMER-CALCIUM CHANNEL BLOCKER CONJUGATES - The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer. | 11-26-2015 |
| 20160052885 | METHOD FOR REFINING QUINOLINIC ACID - Provided is a method for refining quinolinic acid, including the steps of: preparing a fermentation solution including at least one of quinolinic acid and a salt thereof; removing microbial cells from the fermentation solution; preparing an acidic composition containing at least one of quinolinic acid and a salt thereof at a saturation concentration or more by adding an acid to the fermentation solution; and recovering a crystal of least one of quinolinic acid and a salt thereof from the acidic composition. | 02-25-2016 |
| 546322000 | Carbocyclic ring containing | 4 |
| 20100004459 | 2-PHENYLNICOTINIC ACID DERIVATIVE - The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication. | 01-07-2010 |
| 20120029198 | ESTERS OF O-SUBSTITUTED HYDROXY CARBOXYLIC ACIDS AND PREPARATIONS THEREOF - Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: | 02-02-2012 |
| 20120190861 | Levodopa Prodrugs, and Compositions and Uses Thereof - Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. | 07-26-2012 |
| 20150025247 | ESTERS OF O-SUBSTITUTED HYDROXY CARBOXYLIC ACIDS AND PREPARATIONS THEREOF - Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: | 01-22-2015 |
| 546323000 | Acyclic nitrogen bonded directly to the carbonyl | 7 |
| 20120309978 | ALPHA-CRYSTALLINE FORM OF CARBABENZPYRIDE - The present invention relates to a new crystalline form of carbabenzpyride of formula (I) and the process for its preparation. Further, the invention relates to the use of this new crystalline form of carbabenzpyride in the treatment and prevention of viral infections. | 12-06-2012 |
| 20130109863 | HETERO-SUBSTITUTED ACETANILIDE DERIVATIVES AS ANALGESIC AGENTS | 05-02-2013 |
| 20130172567 | METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL)BORONATES AND METHODS OF USING THE SAME - Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%. | 07-04-2013 |
| 20130245275 | PHENYL DIAMIDES AND A PHARMACEUTICAL PREPARATION COMPRISING PHENYL DIAMIDES - The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1). Further, the present invention relates to phenyl diamides according to the formulas (16), (17) and (18) for use in the treatment of gliomas. | 09-19-2013 |
| 20150291530 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS - The invention relates to a novel process for the preparation of 2-trifluoromethyl isonicotinic acid and esters of the formula I which involves a palladium catalysed carbonylation or cyanation step wherein R | 10-15-2015 |
| 20160137605 | SELECTIVE PLACEMENT OF CARBON NANOTUBES VIA COULOMBIC ATTRACTION OF OPPOSITELY CHARGED CARBON NANOTUBES AND SELF-ASSEMBLED MONOLAYERS - A method of forming a structure having selectively placed carbon nanotubes, a method of making charged carbon nanotubes, a bi-functional precursor, and a structure having a high density carbon nanotube layer with minimal bundling. Carbon nanotubes are selectively placed on a substrate having two regions. The first region has an isoelectric point exceeding the second region's isoelectric point. The substrate is immersed in a solution of a bi-functional precursor having anchoring and charged ends. The anchoring end bonds to the first region to form a self-assembled monolayer having a charged end. The substrate with charged monolayer is immersed in a solution of carbon nanotubes having an opposite charge to form a carbon nanotube layer on the self-assembled monolayer. The charged carbon nanotubes are made by functionalization or coating with an ionic surfactant. | 05-19-2016 |
| 20160168097 | PROCESS FOR THE PREPARATION OF AMIDES FROM HINDERED ANILINES CONTAINING A PERHALOALKYL GROUP | 06-16-2016 |
| 546326000 | The carbonyl is in a -COO- group | 16 |
| 20090131677 | SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY-PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF - The present invention relates to a compound of the formula (I), wherein R | 05-21-2009 |
| 20100217006 | Inhibitor Of Ischemic Disorders - It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same. | 08-26-2010 |
| 20120220780 | LIGAND FOR ASYMMETRIC SYNTHESIS CATALYST, AND PROCESS FOR PRODUCTION OF ALPHA-ALKENYL CYCLIC COMPOUND USING SAME - Disclosed are: a ligand for an asymmetric synthesis catalyst; and a process for producing an α-alkenyl cyclic compound using the ligand. Specifically disclosed are: a ligand for an asymmetric synthesis catalyst, which is represented by any one of formulae (1) to (4) [wherein R | 08-30-2012 |
| 20150344415 | SHIKONIN, ALKANNIN; AND RACEMIC PARENT NUCLEUS CABONYL OXIME DERIVATIVES AND APPLICATIONS THEREOF - A structural formula of a shikonin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (I) or (II); a structural formula of an alkannin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (III) or (IV); and a structural formula of a racemic shikonin naphthazarin parent nucleus hydroxyl methylation carbonyl oxime derivative is shown in Formula (V) or (VI), wherein R1 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms; and R2 is alkane, olefin, arene, or substituting arene comprising 1 to 6 carbon atoms or is H. The shikonin, alkannin, and racemic oxime derivatives of the present invention have novel structures, and in-vitro experiments show that the present invention has good growth inhibitory activity against tumor cells and can be used in tumor treatment. | 12-03-2015 |
| 20160159742 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-CHLORO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C | 06-09-2016 |
| 546327000 | Processes | 11 |
| 20080227984 | Selective Oxidation of Organic Compounds - This invention relates to the selective oxidation of organic compounds. According to the invention organic compounds are selectively oxidized using a peracid or a source of peracid, a transition metal based heterogeneous catalysts and a borate or boric acid in the presence of water. Using the process of the present invention, both excellent conversion and product selectivity maybe obtained. | 09-18-2008 |
| 20080306278 | PROCESS - An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors). | 12-11-2008 |
| 20090143595 | Use of grinding in chemical synthesis - A process for the preparation of a multi-dimensional microporous metal-organic compound comprising the steps of providing a first reactant which includes at least one metal in ionic form, providing a second reactant which includes a bridging organic ligand, grinding the first and second reactants together, wholly or substantially in the absence of solvent. | 06-04-2009 |
| 20100305330 | Process for preparing 2-alkyl-3-halo-6-nitrilpyridine and its carboxylic acid and ester derivatives - A process for preparing 2-alkyl-3-halo-6-nitrilpyridine and its carboxylic acid and ester derivatives by reacting 2-alkyl-3-halo-pyridine N-oxide with dimethyl sulfate, followed by reacting the adduct with alkaline cyanide to obtain the target molecule is disclosed. Further treatment of the nitrile with base to obtain the corresponding acid, and esterification are described as well. The process was scaled up to multi-kilogram level that provided satisfactory output. | 12-02-2010 |
| 20120065405 | PROCESS FOR PRODUCING PYRIDINE CARBOXYLIC ACIDS - Disclosed herein cost effective and ecofriendly large scale process for producing pyridine carboxylic acid with high purity and yield at industrial scale. | 03-15-2012 |
| 20120088918 | Continuous Method For Producing Esters Of Aromatic Carboxylic Acids - The invention relates to a continuous method for producing aromatic carboxylic acid esters by reacting at least one aromatic carboxylic acid of formula (I) Ar—COOH (I), wherein Ar represents an optionally substituted aryl group with 5 to 50 atoms, with at least one alcohol of formula (II) R | 04-12-2012 |
| 20140031558 | FLUOROPICOLINOYL FLUORIDES AND PROCESSES FOR THEIR PREPARATION - Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides. | 01-30-2014 |
| 20150133672 | PROCESS FOR FLUORINATING COMPOUNDS - Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate. | 05-14-2015 |
| 20150133673 | PROCESS FOR FLUORINATING COMPOUNDS - Methods of preparing a fluorinated substrate by combining potassium fluoride, imidazolium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed. | 05-14-2015 |
| 20150141654 | PROCESS FOR FLUORINATING COMPOUNDS - Methods of preparing a fluorinated substrate by combining potassium fluoride, a quaternary ammonium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed. | 05-21-2015 |
| 20160039760 | PROCESS FOR THE PREPARATION OF 4,5,6-TRICHLOROPICOLINIC ACID - 4,5,6-Trichloropicolinic acid is prepared by selectively dechlorinating 3,4,5,6-tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent. | 02-11-2016 |
| 546328000 | Acyclic nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding | 4 |
| 20090005571 | Process for Preparing Imino Compounds - Process for preparing imine compounds, in which a carbonyl compound is reacted with a primary amine. The imine compound obtained in this way can be reacted further with a metalalkyl and subsequently a carbonyl compound to form an imine compound. | 01-01-2009 |
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