| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546304000 | Nitrogen attached directly to the six-membered hetero ring by nonionic bonding | 57 |
| 20080234488 | Method of Deuteration Using Mixed Catalyst - The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. | 09-25-2008 |
| 20100234605 | METHODS AND COMPOSITIONS FOR PRODUCING DIFLUOROMETHYLENE-AND TRIFLUOROMETHYL-CONTAINING COMPOUNDS - New methods for producing difluoromethylene-containing compounds with phenylsulfur trifluoride or a primary alkyl-substituted phenylsulfur trifluoride are disclosed. Also, new methods for producing trifluoromethyl-containing compounds with phenylsulfur trifluoride or primary alkyl-substituted phenylsulfur trifluoride are also disclosed. | 09-16-2010 |
| 20110034698 | Oxonium And Sulfonium Salts - The present invention relates to oxonium salts having [(R | 02-10-2011 |
| 20110124873 | Bis(perfluoralkyl)phosphinous acids and derivatives and use thereof - The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes. | 05-26-2011 |
| 20110160460 | NOVEL MATERIALS USEFUL AS ELECTROLYTIC SOLUTES - The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, 0, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FXI0)N—(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte. | 06-30-2011 |
| 20110201818 | POLO-LIKE KINASE INHIBITORS - Compounds of the following formula are provided for use with kinases: | 08-18-2011 |
| 546305000 | Sulfur and acyclic nitrogen bonded directly to the same carbon | 1 |
| 20150080580 | THIOUREA DERIVATIVES AS a-CHYMOTRYPSIN INHIBITORS - α-Chymotrypsin inhibitors of thiourea class are reported that could be potent inhibitors of proteases, elastases, proteasomes, NS3 and NS4 serine protease of hepatitis C virus, dengue virus, etc. Compounds | 03-19-2015 |
| 546306000 | Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other | 2 |
| 20090156825 | Fluorescent compounds that bind to histone deacetylase - The present invention relates to a novel class of fluorescent compounds that bind to histone deacetylases. The fluorescent compounds can be used to determine binding association and dissociation rates of histone deacetylase inhibitors via fluorescence polarization. | 06-18-2009 |
| 20120157684 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF - The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention. | 06-21-2012 |
| 546307000 | Plural nitrogens attached directly to the six-membered hetero ring by nonionic bonding | 3 |
| 20120264944 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEROF - The invention relates to compounds of general formula (I): | 10-18-2012 |
| 20140200351 | APPARATUS AND PROCESS FOR THE CONTINUOUS REACTION OF LIQUIDS WITH GASES - The present invention relates to an apparatus of the loop Venturi reactor type for the continuous reaction of liquids with gases, in particular for hydrogenations, oxidations or acetylations, e.g. for the preparation of toluenediamine by hydrogenation of dinitrotoluene, and a process for the continuous reaction of liquid reactants with gaseous reactants in the apparatus. The apparatus of the invention comprises one or more ejectors which each comprise a diffuser. | 07-17-2014 |
| 20150094475 | Preparation of Pyridonecarboxylic Acid Antibacterials - A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed. | 04-02-2015 |
| 546309000 | Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen | 23 |
| 20090171096 | Novel process for the preparation of roflumilast - The invention relates to novel processes for the preparation of high-purity roflumilast. | 07-02-2009 |
| 20100036130 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 02-11-2010 |
| 20100197929 | METHODS OF SYNTHESIZING PHARMACEUTICAL SALTS OF A FACTOR XA INHIBITOR - Novel methods of preparing a compound of Formula I which is an inhibitor of Factor Xa and its maleate salt, are described herein. | 08-05-2010 |
| 20100234606 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) - The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields. | 09-16-2010 |
| 20110124874 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF - The present invention aims to provide an iminopyridine derivative compound having an α | 05-26-2011 |
| 20110124875 | IMINOPYRIDINE DERIVATIVES AND USES THEREOF - The present invention aims to provide an iminopyridine derivative compound having an α | 05-26-2011 |
| 20110213157 | TRICYCLIC AMIDE COMPOUND - A compound represented by the following general formula (I): | 09-01-2011 |
| 20110295018 | PROCESS FOR THE MANUFACTURE OF AN INTERMEDIATE IN THE SYNTHESIS OF DABIGATRAN - The invention relates to a process for the synthesis of the diamine of formula (1) an important intermediate in the synthesis of dabiagtran etexilate. | 12-01-2011 |
| 20110319627 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 12-29-2011 |
| 20120071662 | PREPARING AMINOARYLALKYL COMPOUNDS - The invention relates to a process for preparing aminoarylalkyl compounds, more particularly 5-amino-2-isopropylpyridine. | 03-22-2012 |
| 20120264945 | Biological Buffers with Wide Buffering Ranges - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 10-18-2012 |
| 20120316345 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) - The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields. | 12-13-2012 |
| 20130005981 | PROCESS FOR PREPARATION OF t-BUTOXYCARBONYLAMINE COMPOUNDS - Provided is a process for the preparation of t-butoxycarbonylamine compounds, which comprises using phosgene or a phosgene equivalent, t-butanol, and an organic base. Even when applied to a primary or secondary amine compound having low nucleophilicity, the process enables highly selective preparation of a t-butoxycarbonylamine compound at a low cost. In the process, a t-butoxycarbonylamine compound is prepared using: phosgene or a phosgene equivalent; t-butanol; an organic base; and either a primary or secondary amine compound or a primary or secondary ammonium salt. | 01-03-2013 |
| 20130023664 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME - There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R | 01-24-2013 |
| 20130046098 | KINASE INHIBITORS - The present invention relates to compounds of formula (I): wherein A=formula: (a) or formula: (b); X is oxygen or methylene; Y is C | 02-21-2013 |
| 20130211094 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 08-15-2013 |
| 20140046071 | Methods of Synthesizing Pharmaceutical Salts of a Factor Xa Inhibitor - Novel methods of preparing a compound of Formula I which is an inhibitor of Factor Xa and its maleate salt, are described herein. | 02-13-2014 |
| 20140155616 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME - There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R | 06-05-2014 |
| 20140163235 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME - There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R | 06-12-2014 |
| 20140171651 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME - There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R | 06-19-2014 |
| 20140194629 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME - There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R | 07-10-2014 |
| 20140275551 | PROCESS FOR THE PREPARATION OF ROFLUMILAST - The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast. | 09-18-2014 |
| 20150025246 | PROCESS FOR PREPARATION OF ROFLUMILAST - The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided. | 01-22-2015 |
| 546310000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the six-membered hetero ring | 12 |
| 20100121069 | METHOD FOR MANUFACTURING A BETA-DIARYL ELECTRON WITHDRAWING GROUP SUBSTITUTED COMPOUND - An electron withdrawing group substituted β-arylolefin derivative represented by general formula (I) | 05-13-2010 |
| 20110124876 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF - The present invention aims to provide an iminopyridine derivative compound having an α | 05-26-2011 |
| 20120190860 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling. | 07-26-2012 |
| 20120245359 | PROCESS FOR MANUFACTURING 2-[(3,5-DIFLUORO-3'-METHOXY-1,1'-BIPHENYL-4 YL)AMINO]NICOTINIC ACID - The present disclosure relates to a process for manufacturing 2-[(3,5-difluoro-3′-methoxy-1,1′biphenyl-4-yl)amino]nicotinic acid. | 09-27-2012 |
| 20130172565 | METHODS OF FORMING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACID PINACOL ESTERS AND METHODS OF USING THE SAME - Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed. | 07-04-2013 |
| 20130172566 | METHODS OF PRODUCING METHYL 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYL- ATE - Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. | 07-04-2013 |
| 20140031556 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides. | 01-30-2014 |
| 20140039196 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling. | 02-06-2014 |
| 20140171652 | PROCESSES FOR THE ISOLATION OF 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYL- IC ACID - Processes for the preparation and isolation of | 06-19-2014 |
| 20140171653 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-CHLORO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. | 06-19-2014 |
| 20140171654 | PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6-(SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. | 06-19-2014 |
| 20140206881 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling. | 07-24-2014 |
| 546311000 | The nitrogen bonded additionally only to hydrogen | 4 |
| 20100234607 | Process for preparing 2-amino-4- (haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds - A process in which a 2-aminopyridine derivative of the general formula II is obtained from open-chain nitrile precursor I or III by reaction with a nitrogen compound in a cyclization reaction is described. | 09-16-2010 |
| 20100298571 | ARYLAMINE SYNTHESIS METHOD - The invention relates to a method for preparing arylamines and, in particular, a method for preparing aniline and anilines substituted on the aromatic ring from ammonia, under easily-industrialised mild conditions with good selectivity and yields, in the presence of a catalytic system including a copper complex. | 11-25-2010 |
| 20110319628 | ONE-POT PROCESS FOR THE SYNTHESIS OF DALFAMPRIDINE - A process for the preparation of Dalfampridine (1), 4-aminopyridine, starting from 4-pyridinecarbonitrile using a one-pot procedure. | 12-29-2011 |
| 20140121379 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 05-01-2014 |
| 546312000 | Chalcogen attached indirectly to the six-membered hetero ring by nonionic bonding | 6 |
| 20090187026 | Diastereomeric purification of rosuvastatin - The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates. | 07-23-2009 |
| 20100190993 | Biological Buffers with Wide Buffering Ranges - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 07-29-2010 |
| 20110060145 | PROCESS FOR PRODUCTION OF COMPOUND HAVING ANTAGONISTIC ACTIVITY ON NPYY5 RECEPTOR, AND USEFUL CRYSTAL - Disclosed are process for producing a compound having NPYY5 receptor antagonism and useful crystals. | 03-10-2011 |
| 20120197023 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF - The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-α,α,α-trifluoro-2,6-di-nitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops. | 08-02-2012 |
| 20140221662 | INTERMEDIATE COMPOUNDS OF TAMIFLU, METHODS OF PREPARATION AND USES THEREOF - Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds. | 08-07-2014 |
| 20160194283 | Biological Buffers with Wide Buffering Ranges | 07-07-2016 |
