| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546290000 | Chalcogen bonded directly to ring carbon of the six-membered hetero ring | 84 |
| 20090043102 | METHOD FOR PRODUCING HETEROAROMATIC ALCOHOLS - A process for preparing heteroaromatic alcohols by catalytically hydrogenating heteroaromatic carboxylic acids or esters thereof by hydrogenating with hydrogen in the presence of a ruthenium-phosphine complex in an organic solvent. | 02-12-2009 |
| 20090143594 | PROCESS FOR THE CATALYTIC SYNTHESIS OF DIARYL ETHERS - Described is a process for preparing diaryl ethers of the formula (I) | 06-04-2009 |
| 20090198068 | SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR THE PREPARATION THEREOF - The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100° C. with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 ° C. | 08-06-2009 |
| 20090286987 | METALLOPROTEIN INHIBITORS - The present invention relates to metalloprotein inhibitors comprising:
| 11-19-2009 |
| 20100174089 | HETEROARYL ARYL ETHERS - The present invention relates to a process for the preparation of optionally substituted heteroaryl aryl ethers, in particular of phenoxypyridines. | 07-08-2010 |
| 20110137041 | PROCESS FOR PREPARING ATOVAQUONE AND ASSOCIATE INTERMEDIATES - The invention provides novel intermediates of atovaquone and use thereof for the preparation of atovaquone | 06-09-2011 |
| 20120016133 | Method for Synthesizing Pirfenidone - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 01-19-2012 |
| 20130018193 | DEUTERATED PIRFENIDONE - This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor. | 01-17-2013 |
| 20130261309 | Process for Preparing Alkali Metal Pyrithione and its Polyvalent Metal Complexes from Pyridine Oxide - The present invention generally relates to a novel process for preparing alkali metal pyrithione from pyridine N-oxide, using a sulfurination agent and a base agent. In particular, the present invention relates to an efficient process for preparing polyvalent metal complexes of sodium pyrithione from the alkali metal pyridine N-oxide described herein. | 10-03-2013 |
| 20130345430 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 12-26-2013 |
| 20140221660 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 08-07-2014 |
| 20150065720 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 03-05-2015 |
| 20150321982 | Catalytic C-H Bond Activation - Disclosed is a method for the transition metal-mediated oxidation of C—H bonds to form C—O or C—S bonds. The methods are useful for the formation of ethers (R—OR′) from alcohols, R′OH, and sp | 11-12-2015 |
| 20150368200 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 12-24-2015 |
| 546291000 | Chalcogen and acyclic nitrogen bonded directly to the same carbon | 12 |
| 20080249313 | Process for the Preparation of Pyridylcarboxylic Amides and Esters - The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R | 10-09-2008 |
| 20090018340 | Formation of Tetra-Substituted Enamides and Stereoselective Reduction Thereof - The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I). | 01-15-2009 |
| 20090209767 | 2-(Butyl-1-sulfonylamino)-n-[1(R)-(6-methoxy-pyridin-3-yl)-propyl]-benzami- d, the use thereof in the form of drug an pharmaceutical preparations containing said compound - The invention relates to 2-(butyl-1-sulfonylamino)-N-[1(R)-(6-methoxy-pyridin-3-yl)propyl]benzamide of the formula I | 08-20-2009 |
| 20120136157 | ARYL UREAS AS KINASE INHIBITORS - This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders. | 05-31-2012 |
| 20130005980 | PROCESS FOR THE PREPARATION OF SORAFENIB TOSYLATE - The present invention provides a process for the preparation of sorafenib tosylate, comprising contacting sorafenib free base with p-toluenesulphonic acid in water. | 01-03-2013 |
| 20130035492 | METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED OMEGA-DIPHENYLUREA - Methods and processes for preparation and production of deuterated ω-diphenylurea are disclosed. Especially, a kind of deuterated ω-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenye-N′-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases. | 02-07-2013 |
| 20130116442 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE - The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate. | 05-09-2013 |
| 20140005405 | PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS | 01-02-2014 |
| 20140088311 | METHOD FOR PREPARING DEUTERATED DIPHENYLUREA - Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative. | 03-27-2014 |
| 20140221661 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE - The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate. | 08-07-2014 |
| 20150133670 | PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III - The present invention provides a novel process for the preparation of sorafenib tosylate polymorph III. | 05-14-2015 |
| 546292000 | The chalcogen or the acyclic nitrogen is bonded directly to the six membered hetero ring | 1 |
| 20090137814 | Synthesis of diaminodinitropyridine - A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene, with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed. | 05-28-2009 |
| 546293000 | Sulfur bonded directly to acyclic nitrogen | 1 |
| 20110046385 | Polymorphs Of Prostaglandin Agonists And Methods For Making The Same - The present invention relates to polymorphic crystalline forms or a non-crystalline form or amorphous of the compound (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid sodium salt or a hydrate thereof together with processes for preparing, methods for using, and pharmaceutical compositions containing the same. The invention also relates to substantially pure polymorphic crystalline forms or a non-crystalline form or amorphous form of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid sodium salt or a hydrate thereof. | 02-24-2011 |
| 546294000 | Chalcogen bonded directly to chalcogen | 7 |
| 20100280252 | POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS - The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof. | 11-04-2010 |
| 20110137042 | Process for Synthesis of Intermediates Useful for Making Substituted Indazole and Azaindazole Compounds - Disclosed are processes for preparing compounds of formula (I): | 06-09-2011 |
| 20120136158 | Pyridinyl Compounds Useful As Intermediates - Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. | 05-31-2012 |
| 20120259124 | COMPOSITION, SYNTHESIS AND USE OF ISONITRILES - The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof. | 10-11-2012 |
| 20130158271 | BIVALENT LINKERS AND CONJUGATES THEREOF - Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described. | 06-20-2013 |
| 20160002167 | BIVALENT LINKERS AND CONJUGATES THEREOF - Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described. | 01-07-2016 |
| 20160137604 | PURIFICATION OF INTERMEDIATES USED IN THE PREPARATION OF HETEROBIFUNCTIONAL LINKERS - The present invention is directed to a method of separating a monocarboxylic represented by the following stmctural formula: (I) from a dicarboxylic acid represented by the following structural fonnula: (II) using silica chromatography. | 05-19-2016 |
| 546296000 | Plural chalcogens bonded directly to ring carbons of the six-membered hetero ring | 7 |
| 20090171095 | PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND - A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of —O—, —S—, —NH—, and —NR | 07-02-2009 |
| 20100076199 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDONE CARBOXYLIC ACIDS - The present invention relates to methods for the preparation of pyridone carboxylic acids for use as intermediates in the preparation of various synthetic organic compounds. The pyridone carboxylic acids can for example be used as intermediates in the production of potent antitumor agents, antifungal agents, antiviral agents, psychotherapeutic agents or contrast imaging agents for MRI. | 03-25-2010 |
| 20130211093 | Process for the Preparation of 1-Hydroxy-6-Substituted Pyridones - Disclosed herein is a cost effective and environmentally friendly process to prepare 1-hydroxy-6-substituted pyridones from 2,6-dichloropyridine. The process includes the steps of (a) reacting 2,6-dichloropyridine with hydrogen peroxide in the presence of trifluoroacetic acid at a first temperature to produce a first intermediate containing (1) trifluoroacetic acid and (2) 2,6-dichloropyridine N-oxide and/or salts thereof; (b) adding sulfuric acid to the first intermediate to provide a second intermediate; (c) removing trifluoroacetic acid from the second intermediate to provide a composition containing 2,6-dichloropyridine N-oxide and/or salts thereof which is essentially free of trifluoroacetic acid; (d) reacting 2,6-dichloropyridine N-oxide and/or salts thereof from step (c) with RXH and a base wherein each R is independently a substituted or unsubstituted hydrocarbyl group having between 1 and 20 carbon atoms, X is oxygen or sulfur, to produce a corresponding 2,6-disubstituted-pyridine N-oxide; and (e) heating the disubstituted compound thereby producing the 1-hydroxy-6-substituted pyridone. | 08-15-2013 |
| 20140031555 | CHEMICAL COMPOUNDS - The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. | 01-30-2014 |
| 20140206880 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE - A process for the preparation of 4-methyl-oxazole-5-carboxamide, an intermediate in the synthesis of pyridoxine, by reacting lower alkyl 4-methyl-oxazole-5-carboxy-late with a molar excess of anhydrous, liquid ammonia. | 07-24-2014 |
| 20150148545 | PROTEIN TYROSINE PHOSPHATASE INHIBITOR, PREPARATION METHOD AND USES THEREOF - Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the | 05-28-2015 |
| 20150299124 | SYNTHESIS OF UV ABSORBING COMPOUNDS - A method of synthesis is provided to obtain a range of UV absorbing compounds. The method broadly involves (a) the reduction of a glutarimide or its reaction with a carbon nucleophile; (b) when step (a) is a reduction, exposing the product of step (a) to an acidic environment to form a cyclic amide; (c) reducing the product of step (a) or step (b) to form a corresponding enamine; and subjecting the enamine product of step (c) to an acylation. | 10-22-2015 |
| 546297000 | Nitrogen attached directly to the six-membered hetero ring by nonionic bonding | 3 |
| 20090247762 | METHOD FOR PRODUCING THIOCARBAMATE DERIVATIVE - An O-aryl N-(6-alkoxy-2-pyridyl)-N-alkylthiocarbamate represented by the following formula (I): | 10-01-2009 |
| 20130178633 | PHENOL DERIVATIVES AND THE PHARMACEUTICAL OR COSMETIC USE THEREOF - The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): | 07-11-2013 |
| 20140012007 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 01-09-2014 |
| 546298000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the six-membered hetero ring | 19 |
| 20080262236 | Process for the Preparation of 4-Carbonyl)Amino]Phenoxy}-N-Methylpyridine-2-Carboxamide - The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoro-methyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt. | 10-23-2008 |
| 20080262237 | BLACK PIGMENT, BLACK PIGMENT DISPERSION AND BLACK RESIN COMPOSITION COMPRISING THE SAME - The present invention provides a black pigment consisting of an oxonol compound having a mean particle diameter ranging from 0.01 to 10.0 micrometers, and a black pigment dispersion and a black resin composition comprising the black pigment. | 10-23-2008 |
| 20090054656 | METHOD FOR PRODUCING NICOTINIC ACID DERIVATIVE OR SALT THEREOF - To provide a method for producing a specific nicotinic acid derivative or a salt thereof. A method for producing a nicotinic acid derivative represented by the formula (I): | 02-26-2009 |
| 20090093638 | Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions - The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers. | 04-09-2009 |
| 20090240059 | Monovalent and Divalent Salts of N-(5-Hydroxynicotinoil) -L-Glutamic Acid Exhibiting Psychotropic (Antidepressant and Anxiolytic), Neuroprotective, Geroprotective and Cerebroprotective Action - The invention relates to medicine, in particular to mono- and divalent salts of N-(5-hydroxynicotinoil)-L-glutaminic acid exhibiting psychotropic antidepressant, anxiolytic, heroprotective, neuroprotective, antihypoxia cerebroprotective and nootropic action. The novel compounds differ from the known preparations, including the closest prior art in the form of a N-(5-hydroxynicotinoil)-L-glutaminic acid base (nooglucotyl), in that they produce psychotropic effects, namely antidepressant, anxiolytic, neuroprotective and heroprotective actions, in such a way that lesion focuses caused by apoplectic attacks are reduced and age-specific neurological deficiencies and intellectual and physical work capacities are improved. | 09-24-2009 |
| 20090253913 | Process for the preparation of sorafenib and salts thereof - Methods for the synthesis of the N-carbamoyl imidazole (I) and its 1:1 adduct with imidazole are provided. Methods for the preparation of these crystalline intermediates in a high state of purity are also provided. These intermediates react cleanly under mild conditions to produce sorafenib in high yield and purity, without generating difficult-to-remove impurities. | 10-08-2009 |
| 20100094017 | USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS - Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with pyridinic compounds to produce functionalized pyridinic compounds. | 04-15-2010 |
| 20100190992 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof - Nicotinamide compounds of the formula (1) | 07-29-2010 |
| 20110201817 | LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF - Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. | 08-18-2011 |
| 20120101282 | PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES - The present invention relates to a process for the preparation of nicotinamide derivatives of formula I, | 04-26-2012 |
| 20130060043 | PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA - A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof. | 03-07-2013 |
| 20130060044 | METHOD FOR PREPARING DEUTERATED DIPHENYLUREA - Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative. | 03-07-2013 |
| 20130274478 | POLYMORPHS OF SORAFENIB ACID ADDITION SALTS - The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them, and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib. | 10-17-2013 |
| 20140128612 | DEUTERATED OMEGA DIPHENYLUREA RELATED COMPOUNDS AND INTERMEDIATES - Methods and processes for preparation and production of deuterated ω-diphenylurea are disclosed. Especially, a kind of deuterated ω-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases. | 05-08-2014 |
| 20150361043 | PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES - Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired. | 12-17-2015 |
| 20160009647 | PROCESS FOR THE PREPARATION OF 3-HYDROXYPICOLINIC ACIDS | 01-14-2016 |
| 20160083347 | MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF - The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus. | 03-24-2016 |
| 20160251313 | PROCESS FOR REGORAFENIB | 09-01-2016 |
| 20190144391 | Process for the Preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide | 05-16-2019 |
| 546300000 | Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding | 14 |
| 20090318703 | CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT - A carboxylic acid derivative of formula (I): | 12-24-2009 |
| 20100041892 | Therapeutic agent for diabetes - The present invention provides an agent for the prophylaxis or treatment of diabetes, which is associated with a fewer side effects such as body weight gain, adipocyte accumulation, cardiac hypertrophy and the like, and which contains a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. | 02-18-2010 |
| 20100041893 | FORMATION OF TETRA-SUBSTITUTED ENAMIDES AND STEREOSELECTIVE REDUCTION THEREOF - The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I). | 02-18-2010 |
| 20100204481 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS - Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine. | 08-12-2010 |
| 20110034697 | PROCESS FOR PREPARING 2-HYDROXY-4-SUBSTITUTED PYRIDINES - A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. | 02-10-2011 |
| 20120184749 | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers - The invention relates to a process for the production of radiotracers. In particular, this invention relates the isolation of radiotracers with containers filled with a stationary phase. | 07-19-2012 |
| 20130116443 | METHOD FOR PRODUCING SUBSTITUTED PYRIDIN-2-ONE - The present invention relates to a process for the preparation of substituted 3-(2-hydroxyethyl)-1-[4-nitrophenyl]pyridin-2(1H)-ones which serve as important intermediate compounds for producing drugs. | 05-09-2013 |
| 20130165659 | PRODUCTION METHOD OF INTERMEDIATE COMPOUND FOR SYNTHESIZING MEDICAMENT - The present invention relates to a novel method for preparing a compound of formula (2) as the intermediate, which can be effectively used for preparation of a compound of formula (1) exhibiting good inhibitory activity against dipeptidyl peptidase IV enzyme. | 06-27-2013 |
| 20130225827 | New Process for the Preparation of Aryl Substituted Olefinic Amines - An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine and (2S)-(4E)-N-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine and new intermediates used in said process. | 08-29-2013 |
| 20140024835 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS - The invention is directed to compounds having the formula: | 01-23-2014 |
| 20140243533 | METHOD FOR PRODUCTION OF F-18 LABELED A-BETA LIGANDS - This invention relates to improved methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives. | 08-28-2014 |
| 20150011773 | RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING - This invention relates to novel compounds suitable for labeling by | 01-08-2015 |
| 20150065721 | METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE - Provided is a method for producing an aromatic amide derivative represented by Formula (4), the method including a process in which an aromatic amide derivative represented by Formula (1) and a haloalkyl compound represented by Formula (3) are reacted with each other in the presence of a base and a metal or metal salt. In the formulae, each of X and Y represents a hydrogen atom, a halogen atom, or the like. A represents a hydrogen atom, an alkyl group, a group represented by Formula (2), or the like. Each of G | 03-05-2015 |
| 20160145211 | METHOD FOR PRODUCING 2,3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDINE - The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl as chlorinating agent at elevated temperature and pressure. | 05-26-2016 |
| 546301000 | Chalcogen attached indirectly to the six-membered hetero ring by nonionic bonding | 6 |
| 20080262238 | Dendron and Dendrimer, Method of Producing the Same, and Method of Producing a Thioacetal Compound - A dendron or dendrimer, which has, as a recurring unit of each branch, a structure of formula (I): | 10-23-2008 |
| 20110124872 | DERIVATIVES OF PRYIDONE AND USE THEREOF - The present invention provides N-substituted-2(1H) pyridones or the pharmaceutical acceptable salts thereof, and the pharmaceutical preparations containing the compounds. The compounds of the present invention can be used to treat various fibrotic diseases effectively, e.g., hepatic fibrosis. | 05-26-2011 |
| 20130131350 | PYRIDIN-2YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R | 05-23-2013 |
| 20150299090 | SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF - The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof | 10-22-2015 |
| 546302000 | Halogen attached directly or indirectly to the six-membered hetero ring by nonionic bonding | 2 |
| 20110144347 | PROCESS FOR THE EPIMERIZATION OF ATOVAQUONE ISOMER, ATOVAQUONE INTERMEDIATES AND MIXTURE THEREOF - Provided is a process for the epimerization of the cis isomer of atovaquone, atovaquone intermediates and isomeric mixtures thereof into their corresponding trans-isomers resulting in higher yield of pure atovaquone. | 06-16-2011 |
| 20130023663 | SUBSTITUTED STILBENES AND THEIR REACTIONS - The present invention relates to stilbene and quinine compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis- or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BBOC amino acid esters are formed with the phenolic hydroxyl at the 3 -position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior stilbenes. These reactions include the photochemical release of an active form of the compound from a prodrug conjugate and the photochemical isomerization of the compounds, especially from a trans to cis form of compounds. The reactions can be used alone or in combination to convert inactive or comparatively less active forms of the compounds to more active forms, thereby allowing the compounds to be selectively targeted, e.g., activating them at the site of a tumour. | 01-24-2013 |
| 546303000 | Halogen attached directly or indirectly to the six-membered hetero ring by nonionic bonding | 1 |
| 20130096312 | Process for Preparing 4-hydroxypyridines - The present invention relates to a process for preparing 4-hydroxypyridines of formula I | 04-18-2013 |
