| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 546281700 | Ring oxygen in the additional hetero ring | 44 |
| 20090216024 | Processes for making pioglitazone and compounds of the processes - Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process. | 08-27-2009 |
| 20090275756 | 2-OXETANONE DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF - An aldehyde derivative represented by the general formula ( | 11-05-2009 |
| 20150112079 | BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES - Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc. | 04-23-2015 |
| 546282100 | The additional hetero ring is six-membered | 14 |
| 20100184989 | De Novo Synthesis of Conjugates - The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path. | 07-22-2010 |
| 20140309427 | Substituted Pyran Derivatives - Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated. | 10-16-2014 |
| 546282400 | Plural ring oxygens in the additional hetero ring | 4 |
| 20120172602 | POLYMERS BEARING PENDANT PENTAFLUOROPHENYL ESTER GROUPS, AND METHODS OF SYNTHESIS AND FUNCTIONALIZATION THEREOF - A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization. | 07-05-2012 |
| 20120172603 | POLYMERS BEARING PENDANT PENTAFLUOROPHENYL ESTER GROUPS, AND METHODS OF SYNTHESIS AND FUNCTIONALIZATION THEREOF - A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization. | 07-05-2012 |
| 20120309977 | PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES - Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]aminolacetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired. | 12-06-2012 |
| 20140155615 | COMPOUND CONTAINING PYRIDINE RING AND METHOD FOR PRODUCING HALOGENATED PICOLINE DERIVATIVE AND TETRAZOLYLOXIME DERIVATIVE - Disclosed is a compound containing a pyridine ring | 06-05-2014 |
| 546282700 | Polycyclo ring system having the additional hetero ring as one of the cyclos | 8 |
| 20120123129 | Cyclopentanedione Compounds and Their Use as Insecticides, Acaricides and/or Fungicides - The present invention relates to the use of compounds of Formula (I) | 05-17-2012 |
| 546283100 | Chalcogen attached directly to the additional hetero ring by nonionic bonding | 7 |
| 20090259048 | FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES - The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis. | 10-15-2009 |
| 20100160640 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES AND INTERMEDIATES FOR THE PRODUCTION THEREOF - Disclosed is a process for producing compound C represented by formula C: | 06-24-2010 |
| 20120046470 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES - Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base. | 02-23-2012 |
| 20120330021 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES AND INTERMEDIATES FOR THE PRODUCTION THEREOF - A process for producing compound C represented by formula C is disclosed: | 12-27-2012 |
| 20120330022 | METHOD FOR PRODUCING PYRIPYROPENE DERIVATIVES BY THE ENZYMATIC METHOD - There is provided a method for producing a pyripyropene derivative represented by the following formula A by an enzyme method. The production method of the present invention allows for production of a pyripyropene derivative under simpler conditions and in shorter steps. | 12-27-2012 |
| 20130060042 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES - Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base. | 03-07-2013 |
| 20160046644 | Method for Preparing a Pyripyropene Compound - The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i). | 02-18-2016 |
| 546283400 | The additional hetero ring is five-membered | 27 |
| 546283700 | Plural ring oxygens in the additional hetero ring | 12 |
| 20090030209 | METHOD FOR PRODUCING PENTACYCLIC TAXANS - Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds. | 01-29-2009 |
| 20090176989 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 07-09-2009 |
| 20090264660 | PROCESS FOR ALKYL ARYL SULFIDE DERIVATIVES AND NEW SULFIDE COMPOUNDS - An alkyl aryl sulfide of Chemical Formula (III) is prepared by substituting an aryl halogen compound of Chemical Formula (I) with an alkyl lithium organometallic reagent. The sulfide is subsequently reacted with a compound of Chemical Formula (II). Alternatively an aryl halogen compound of Chemical Formula (I) is reacted with Grignard reagent to protect the hydrogen-donating substituent, and then reacted with an alkyl lithium organometallic reagent, and subsequently with sulfur and a compound of Chemical Formula (II). An alkyl aryl sulfide of Chemical Formula (III) is prepared via a one-step reaction without separation or purification of an intermediate compound from various aryl halogen compounds. | 10-22-2009 |
| 20120071661 | Ionic Liquid Solvents - A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O—) directly linked to the core and an associated counter anion, characterized in that the —O— atom of the ester side chain is linked to an alpha, a beta or a gamma hydroxycarboxylic acid functionality via the alpha, beta or gamma hydroxy of the acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon, or characterized in that an —N═ atom of the alkyl substituted imidazolium or pyridinium cationic core is substituted with an alpha, a beta or a gamma hydroxy group of a alpha, a beta or a gamma hydroxycarboxylic acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon. The chiral ionic liquids (CILs) may be used as novel solvents, in particular for organic synthesis. The CILs have the potential to induce asymmetry into substrates or catalysts in a variety of organic transformations. A number of the compounds have low antimicrobial and low antifungal toxicities and are also biodegradable CILs. | 03-22-2012 |
| 20120190856 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 07-26-2012 |
| 20120203006 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 08-09-2012 |
| 20130274477 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 10-17-2013 |
| 20140330023 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 11-06-2014 |
| 20160002211 | METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES - The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same. | 01-07-2016 |
| 20160052916 | SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-- METHYLPYRIDIN-2-YL) BENZOIC ACID - The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith. | 02-25-2016 |
| 20160200712 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS | 07-14-2016 |
| 20160376284 | TAXANE COMPOUNDS, COMPOSITIONS AND METHODS - The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation. | 12-29-2016 |
| 546284100 | Polycyclo ring system having the additional hetero ring as one of the cyclos | 5 |
| 20090143593 | SYNTHESIS OF HETEROCYCLIC COMPOUNDS - Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof. | 06-04-2009 |
| 20090192315 | SYNTHESIS OF HETEROCYCLIC COMPOUNDS - Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof. | 07-30-2009 |
| 20100056796 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits - The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form. | 03-04-2010 |
| 20120264943 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits - The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form. | 10-18-2012 |
| 20140296534 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS - The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form. | 10-02-2014 |
| 546284400 | Chalcogen attached directly to the additional hetero ring by nonionic bonding | 8 |
| 20090182150 | Novel Intermediate for the Preparation of Paliperidone - A new compound of formula (IV) | 07-16-2009 |
| 20100190990 | Method for Producing 4-Aminobut-2-Enolides - Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are reduced to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A radical is as defined in the description: | 07-29-2010 |
| 20100204480 | METHOD FOR PRODUCING 4-AMINOBUT-2-ENOLIDES - The present invention relates to a process for preparing 4-aminobut-2-enolides and also corresponding intermediates and starting compounds which are passed through or used in the process according to the invention. | 08-12-2010 |
| 20110054182 | Novel Process for the Preparation of 4-Aminobut-2-enolides - Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): | 03-03-2011 |
| 20110152534 | NOVEL PROCESS FOR THE PREPARATION OF 4-AMINOBUT-2-ENOLIDES STARTING FROM 4-ALKOXYFURAN-2(5H)-ONE OR 4-ARYLALKOXYFURAN-2(5H)-ONE - Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): | 06-23-2011 |
| 20120004416 | NOVEL METHOD FOR PRODUCING ENAMINOCARBONYL COMPOUNDS - The present invention relates to a process for preparing enaminocarbonyl compounds by reacting compounds of the formula (II) | 01-05-2012 |
| 20120016132 | NOVEL METHOD FOR PRODUCING ENAMINOCARBONYL COMPOUNDS - The present invention relates to a process for the preparation of enaminocarbonyl compounds of the formula (I) | 01-19-2012 |
| 20150051403 | Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus - Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage. | 02-19-2015 |
| 546284700 | Nitrogen or -C(=X)-, wherein X is chalcogen, attached directly to the additional hetero ring by nonionic bonding | 2 |
| 20080207909 | Preparation of 11C Methyl Iodide - A process for the preparation of | 08-28-2008 |
| 20140039195 | Squarylated Lactones Inhibitors for Bacterial Biofilm Formation - A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 μM), these small molecules inhibit biofilm formation of | 02-06-2014 |
